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Journal of Virus Eradication

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https://www.readbyqxmd.com/read/28435696/highlights-from-the-24-th-conference-on-retroviruses-and-opportunistic-infections-13-16-february-2017-seattle-washington-usa
#1
EDITORIAL
Trevor A Crowell, Hermione Lyall, Eva Malatinkova, Sanjay Bhagani, Denise Hsu, Donn J Colby, Christina Polyak, Christina Psomas, Andrew Hill, Esther N Gathogo, Wim Trypsteen, Linos Vandekerckhove, Sabine Kinloch
From the 13th to 16th February 2017, researchers from around the world convened for the 24th annual Conference on Retroviruses and Opportunistic Infections (CROI) at the Washington State Convention Center in Seattle, Washington. The conference was organised by the International Antiviral Society-USA (IAS-USA) in partnership with the CROI Foundation. The conference included over 1000 oral and poster presentations of peer-reviewed original research as well as lectures and symposia featuring insights from leading basic, translational and clinical researchers...
April 1, 2017: Journal of Virus Eradication
https://www.readbyqxmd.com/read/28435695/highlights-of-the-international-congress-on-drug-therapy-in-hiv-infection-23-26-october-2016-glasgow-uk
#2
EDITORIAL
Julio Montaner, Pablo Rojo, Tarandeep Anand, Jürgen Rockstroh
No abstract text is available yet for this article.
April 1, 2017: Journal of Virus Eradication
https://www.readbyqxmd.com/read/28435694/highlights-from-the-hiv-research-for-prevention-conference-r4p-17-21-october-2016-chicago-il-usa
#3
EDITORIAL
Sandhya Vasan, Tanyaporn Wansom, Alexandra Schuetz, Shelly Krebs, Rasmi Thomas, Gustavao Kijak, Christina Polyak
No abstract text is available yet for this article.
April 1, 2017: Journal of Virus Eradication
https://www.readbyqxmd.com/read/28435693/the-post-condom-era-or-the-urgent-need-to-provide-effective-contraception-for-women-living-with-hiv
#4
EDITORIAL
Karoline Aebi-Popp
No abstract text is available yet for this article.
April 1, 2017: Journal of Virus Eradication
https://www.readbyqxmd.com/read/28435692/a-cd3-cd28-microbead-based-hiv-1-viral-outgrowth-assay
#5
EDITORIAL
Yury V Kuzmichev, Rebecca T Veenhuis, Christopher W Pohlmeyer, Caroline C Garliss, Victoria Ek Walker-Sperling, Joel N Blankson
AIMS: Latently infected resting CD4 T cells represent a major barrier to HIV-1 eradication efforts. The standard assays used for measuring this reservoir induce activation of resting CD4 T cells with either phytohaemagglutinin (PHA) with irradiated feeder cells, or with anti-CD3 antibodies. We designed a study to compare the sensitivity of a new assay (based on the stimulation of CD4 T cells with anti-CD3 and anti-CD28 coated microbeads) with that of the traditional PHA- and feeder-based viral outgrowth assay...
April 1, 2017: Journal of Virus Eradication
https://www.readbyqxmd.com/read/28435691/interrupting-antiretroviral-treatment-in-hiv-cure-research-scientific-and-ethical-considerations
#6
EDITORIAL
Samual A Garner, Stuart Rennie, Jintanat Ananworanich, Karine Dube, David M Margolis, Jeremy Sugarman, Randall Tressler, Adam Gilbertson, Liza Dawson
Over the past several years there has been intense activity directed at the possibility of achieving remission or eradication of HIV infection. Current assays for the measurement of latent HIV are insufficient to demonstrate complete clearance of replication-competent HIV. Therefore, the ultimate test for assessing whether investigational interventions have resulted in HIV remission or eradication is to interrupt standard antiretroviral therapy (ART) in a carefully controlled clinical trial setting. These procedures, known as analytic treatment interruptions (ATIs), raise important scientific and ethical questions...
April 1, 2017: Journal of Virus Eradication
https://www.readbyqxmd.com/read/28435690/the-complex-legal-and-ethical-issues-related-to-generic-medications-viral-hepatitis-a-case-study
#7
EDITORIAL
M Danta, N Ghinea
The economic impact of medications is significant, with many countries unable to afford the essential medicines listed by the WHO. Generic medications are one strategy to address this issue. Generic medications are similar to but not the same as originator medications. They have a significant cost advantage because they do not require the background research and development studies to support registration. Consequently, they are gaining increased market share in both the developed and developing world. Many new medications are now licensed to generic manufacturers in the developing world...
April 1, 2017: Journal of Virus Eradication
https://www.readbyqxmd.com/read/28275462/highlights-from-the-third-biennial-strategies-for-an-hiv-cure-meeting-14-16-november-2016-bethesda-md-usa
#8
EDITORIAL
Diane Lawrence, Lillian Kuo, Elizabeth Church, Betty Poon, Stephen Smiley, Brigitte Sanders-Beer, Liza Dawson, Karl Salzwedel
Since the first Strategies for an HIV Cure Meeting organised by the National Institute of Allergy and Infectious Diseases (NIAID) in 2012, one of the primary purposes of the meeting has been to facilitate communication and foster collaboration across the NIAID-funded Martin Delaney Collaboratories for HIV cure research (MDC), the broader HIV cure-related research field, and industry and community stakeholders. This year's meeting agenda reflected NIAID's increasing investment over the last 5 years in research to identify strategies for eradicating or achieving long-term remission of HIV infection...
January 1, 2017: Journal of Virus Eradication
https://www.readbyqxmd.com/read/28275461/hiv-reservoir-characterization-symposium-19-september-2016-ghent-belgium
#9
EDITORIAL
Eva Malatinkova, Ward De Spiegelaere, Linos Vandekerckhove, Magdalena Sips
The HIV Cure Research Center (HCRC) in Ghent organised the first HIV Reservoir Characterization Symposium, and brought together virologists, molecular biologists, immunologists and clinicians to discuss the most recent developments in HIV reservoir characterisation with a view to achieving an HIV cure. The one-day symposium covered new developments in the field of HIV reservoir and HIV cure research, with the latest news on the European HIV cure trials. This report summarises the major themes discussed during the symposium...
January 1, 2017: Journal of Virus Eradication
https://www.readbyqxmd.com/read/28275460/reactivation-of-hiv-1-proviruses-in-immune-compromised-mice-engrafted-with-human-voa-negative-cd4-t-cells
#10
EDITORIAL
Zhe Yuan, Guobin Kang, Wuxun Lu, Qingsheng Li
BACKGROUND: HIV-1 infection remains incurable on antiretroviral therapy (ART) due to virus latency. To date, enhanced co-culture assays, including viral outgrowth assays (VOA), are commonly used to measure HIV-1 latent reservoirs and evaluate latency-reversing agents (LRAs). However, VOA can only reactivate a small fraction of intact proviruses. METHODS: To explore the utility of NOD scid gamma (NSG) mice as an in vivo model to reactivate HIV-1 proviruses from VOA-negative CD4+ T cells, resting CD4+ T cells from an HIV-1 latently infected individual were isolated and the human CD4+ T cells corresponding to VOA-positive and VOA-negative CD4+ T cells were engrafted into NSG mice...
January 1, 2017: Journal of Virus Eradication
https://www.readbyqxmd.com/read/28275459/carbohydrate-lipid-bone-and-inflammatory-markers-in-hiv-positive-adolescents-on-antiretroviral-therapy-and-hormonal-contraception
#11
EDITORIAL
Nadia Kancheva Landolt, Torsak Bunupuradah, Jullapong Achalapong, Pope Kosalaraksa, Witaya Petdachai, Chaiwat Ngampiyaskul, Sasiwimol Ubolyam, Narukjaporn Thammajaruk, Stephen Kerr, Jintanat Ananworanich
BACKGROUND: Little is known about the cumulative effect of HIV antiretroviral therapy (ART) and hormonal contraception (HC) on metabolism and inflammation in HIV-positive women. METHODS: We conducted a cross-sectional assessment of markers for carbohydrate, lipid, bone metabolism, inflammation and coagulation in HIV-positive adolescents on ART and HC (n=37) versus on ART only (n=51) in Thailand. The Wilcoxon rank-sum test was used to assess differences between groups...
January 1, 2017: Journal of Virus Eradication
https://www.readbyqxmd.com/read/28275458/demographic-and-clinical-correlates-of-hiv-1-rna-levels-in-antiretroviral-therapy-naive-adults-attending-a-tertiary-hospital-in-jos-nigeria
#12
EDITORIAL
Joseph Anejo-Okopi, Isaac Okoh Abah, Yakhat Barshep, Augustine Odo Ebonyi, Comfort Daniyam, Samson Ejiji Isa, Gomerep Simji, Stephen Oguche, Patricia Agaba, Patricia Lar, Oche Agbaji, John A Idoko
BACKGROUND: Plasma HIV-RNA viral load (VL) of HIV-infected persons is an important prognostic factor in HIV management. We determined the VL among antiretroviral therapy (ART)-naive patients to identify the association between patients' demographic, clinical and laboratory characteristics with VL. METHOD: A cross-sectional study of 224 ART-naive HIV-1-infected patients (≥15 years of age) accessing care at the Jos University Teaching Hospital AIDS Prevention Initiative in Nigeria ART treatment centre, from October 2010 to April 2011...
January 1, 2017: Journal of Virus Eradication
https://www.readbyqxmd.com/read/28275457/willingness-to-participate-and-take-risks-in-hiv-cure-research-survey-results-from-400-people-living-with-hiv-in-the-us
#13
EDITORIAL
Karine Dubé, David Evans, Laurie Sylla, Jeff Taylor, Bryan J Weiner, Asheley Skinner, Harsha Thirumurthy, Joseph D Tucker, Stuart Rennie, Sandra B Greene
INTRODUCTION: Participation in early-phase HIV cure studies includes clinical risks with little to no likelihood of clinical benefit. Examining the willingness of people living with HIV to participate is important to guide study design and informed consent. Our study examined the overall willingness of people living with HIV to participate in HIV cure research in the US, focusing on perceived risks and benefits of participation. METHODS: We undertook an online survey of adults living with HIV in the US...
January 1, 2017: Journal of Virus Eradication
https://www.readbyqxmd.com/read/28275456/factors-associated-with-time-to-achieve-an-undetectable-hiv-rna-viral-load-after-start-of-antiretroviral-treatment-in-hiv-1-infected-pregnant-women
#14
EDITORIAL
W Snippenburg, Fjb Nellen, C Smit, Amj Wensing, M H Godfried, T Mudrikova
OBJECTIVE: To identify factors associated with the time to viral suppression in women starting antiretroviral treatment (ART) during pregnancy. Knowledge on duration of viral load (VL) decline could help deciding the timing of treatment initiation. METHODS: Highly active antiretroviral treatment (HAART)-naive pregnant women over 18 years of age who started treatment during pregnancy were included. The time to viral suppression was calculated and compared between subgroups...
January 1, 2017: Journal of Virus Eradication
https://www.readbyqxmd.com/read/28275455/country-of-residence-is-associated-with-distinct-inflammatory-biomarker-signatures-in-hiv-infected-patients
#15
EDITORIAL
Maura Manion, Bruno B Andrade, Rebecca DerSimonian, Wenjuan Gu, Adam Rupert, Laura W Musselwhite, Juan G Sierra-Madero, Pablo F Belaunzaran-Zamudio, Ian Sanne, Michael M Lederman, Irini Sereti
BACKGROUND: Inflammation and coagulation biomarkers are independent predictors of morbidity and mortality in HIV-infected patients. The impact of country of residence on these biomarkers is unknown and was investigated in persons at similar stages of HIV infection. METHODS: Cryopreserved plasma specimens were analysed from 267 ART-naive patients with CD4 cell counts <100 cells/μl from Mexico (n=124) and South Africa (n=143). Biomarkers were compared and dimension reduction analyses were performed to highlight biosignatures according to nationality, gender and tuberculosis co-infection...
January 1, 2017: Journal of Virus Eradication
https://www.readbyqxmd.com/read/28275454/implementation-of-an-online-hiv-prevention-and-treatment-cascade-in-thai-men-who-have-sex-with-men-and-transgender-women-using-adam-s-love-electronic-health-record-system
#16
EDITORIAL
Tarandeep Anand, Chattiya Nitpolprasert, Stephen J Kerr, Tanakorn Apornpong, Jintanat Ananworanich, Praphan Phanuphak, Nittaya Phanuphak
OBJECTIVES: Electronic health record (EHR) systems have been infrequently used to support HIV service delivery models to optimise HIV prevention and treatment cascades. We have studied the implementation, uptake and use of an EHR among Thai men who have sex with men (MSM) and transgender (TG) women. METHODS: Participants, e-counselled via the Adam's Love ( www.adamslove.org) support platforms, after having completed risk behaviour questionnaires and being assessed for their HIV risk by online counsellors, were enrolled based on their preference into one of three EHR-supported arms: (1) private clinic-based HIV testing and counselling (HTC); (2) online pretest counselling and private clinic-based HIV testing (hybrid); and (3) online supervised HIV self-testing and counselling (eHTC)...
January 1, 2017: Journal of Virus Eradication
https://www.readbyqxmd.com/read/28275453/insight-into-hiv-2-latency-may-disclose-strategies-for-a-cure-for-hiv-1-infection
#17
EDITORIAL
Suha Saleh, Lenard Vranckx, Rik Gijsbers, Frauke Christ, Zeger Debyser
HIV-1 and HIV-2 originate from two distinct zoonotic transmissions of simian immunodeficiency viruses from primate to human. Although both share similar modes of transmission and can result in the development of AIDS with similar clinical manifestations, HIV-2 infection is generally milder and less likely to progress to AIDS. HIV is currently incurable due to the presence of HIV provirus integrated into the host DNA of long-lived memory cells of the immune system without active replication. As such, the latent virus is immunologically inert and remains insensitive to the administered antiviral drugs targeting active viral replication steps...
January 1, 2017: Journal of Virus Eradication
https://www.readbyqxmd.com/read/28275452/advancing-the-regulatory-path-on-hepatitis-b-virus-treatment-and-curative-research-a-stakeholders-consultation
#18
EDITORIAL
Jonathan Liu, Pedro Goicochea, Timothy Block, Carol L Brosgart, Eric F Donaldson, Oliver Lenz, Seng Gee Lim, Ed G Marins, Poonam Mishra, Marion G Peters, Veronica Miller
Hepatitis B infection remains a significant disease burden around the world, with an estimated two billion individuals infected and 350 million living with chronic hepatitis B. Current antivirals are efficacious, but require lifelong treatment for the majority of infected individuals. The field is galvanised to improve diagnostics and treatment with the goal to develop shorter, finite treatments leading to viral control after treatment discontinuation. Achievement of complete and functional cure is challenged by the complexity of the virus life cycle, the lack of adequate preclinical models, the cccDNA-mediated persistence of HBV in liver cells, the lack of validated biomarkers to predict viral control and cure, and the probable need for combination treatment involving antiviral- and immune-based strategies...
January 1, 2017: Journal of Virus Eradication
https://www.readbyqxmd.com/read/28303199/hiv-aids-in-the-south-east-asia-region-progress-and-challenges
#19
EDITORIAL
Razia Pendse, Somya Gupta, Dongbao Yu, Swarup Sarkar
The South-East Asia region, with 11 member states, has an estimated 3.5 million people living with HIV (PLHIV). More than 99% of PLHIV live in five countries where HIV prevalence among the population aged 15-49 remains low but is between 2% and 29% among key populations. Since 2010, the region has made progress to combat the epidemic. Mature condom programmes exist in most countries but opioid substitution therapy, and needle and syringe exchange programmes need to be scaled up. HIV testing is recommended nationwide in four countries and is prioritised in high prevalence areas or for key populations in the rest...
November 28, 2016: Journal of Virus Eradication
https://www.readbyqxmd.com/read/28275451/twenty-two-years-of-hiv-infection-in-bhutan-epidemiological-profile
#20
EDITORIAL
Pandup Tshering, Karma Lhazeen, Sonam Wangdi, Namgay Tshering
AIMS: To describe the HIV epidemiology in Bhutan. METHODS: Data from the database of people living with HIV infection in Bhutan, survey reports from the National STI and HIV/AIDS Control Programme from the Ministry of Health and published literature on HIV in Bhutan were reviewed. RESULTS: Bhutan continues to have a low HIV prevalence with only 470 cases reported by the end of 2015. However, there is a slow but steady recent increase in the number of cases...
November 28, 2016: Journal of Virus Eradication
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