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Journal of Virus Eradication

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https://www.readbyqxmd.com/read/28758027/australasian-society-for-hiv-viral-hepatitis-and-sexual-health-medicine-hiv-pre-exposure-prophylaxis-clinical-guidelines
#1
EDITORIAL
Edwina Wright, Andrew Grulich, Katy Roy, Mark Boyd, Vincent Cornelisse, Darren Russell, Darryl O'Donnell, Bill Whittaker, Levinia Crooks, Iryna Zablotska
Daily use of coformulated tenofovir and emtricitabine for HIV pre-exposure prophylaxis (PrEP) by populations at high risk of HIV infection is now recommended in guidelines from the United States, Europe and Australia and globally through the 2015 WHO guidelines. These 2017 Australasian Society for HIV, Viral Hepatitis and Sexual Health Medicine's (ASHM) PrEP Guidelines are an updated adaptation of the 2014 US Centers for Disease Control's PrEP guidelines and are designed to: •Support the prescription of PrEP using forms of coformulated tenofovir and emtricitabine that have been registered in Australia by the Therapeutic Goods Administration and other bioequivalent generic drugs that are available in Australia through self-importation, private prescription or Australian PrEP clinical trials•Assist clinicians in the evaluation of patients who are seeking PrEP•Assist clinicians in commencing and monitoring patients on PrEP including PrEP dosing schedules, management of side-effects and toxicity, use of PrEP in pregnancy and in chronic hepatitis B infection and how to cease PrEP Daily PrEP with co-formulated tenofovir and emtricitabine, used continuously or for shorter periods of time, is recommended in these guidelines as a key HIV-prevention option for men who have sex with men (MSM), transgender men and women, heterosexual men and women, and people who inject drugs (PWID) at substantial risk of HIV acquisition...
July 1, 2017: Journal of Virus Eradication
https://www.readbyqxmd.com/read/28758026/scaling-up-hiv-self-testing-in-china-and-africa
#2
EDITORIAL
Joseph D Tucker, J Ong, D Conserve, S Pan, W Tang
No abstract text is available yet for this article.
July 1, 2017: Journal of Virus Eradication
https://www.readbyqxmd.com/read/28758025/pursuing-ethical-coherence-in-the-prevention-of-vertical-transmission-of-hiv-justice-and-injustice-in-option-b
#3
EDITORIAL
Nathan Hodson, Susan Bewley
Improved prevention of vertical transmission of HIV is an essential part of the global response to HIV. The Option B+ strategy took the extraordinary step of treating many non-pregnant women living with HIV (those with CD4 cell counts >350 cells/mm(3)) in the absence of evidence that they themselves would benefit from ART. This example of so-called AIDS exceptionalism reflects an understanding that the global response to HIV demands a different set of morals. This philosophical article explores a retrospective analysis of the ethical arguments made in support of Option B+ incorporating utilitarian, feminist and equity-based frameworks...
July 1, 2017: Journal of Virus Eradication
https://www.readbyqxmd.com/read/28758024/serum-lipid-and-glucose-profiles-in-hiv-positive-nigerian-children
#4
EDITORIAL
Olukemi O Ige, Christopher S Yilgwan, Augustine O Ebonyi, Ruth Adah, Idris Adedeji, Esther S Yiltok, Stephen Oguche, Fidelia Bode-Thomas
OBJECTIVES: To describe the fasting serum lipid and glucose profiles of HIV-positive Nigerian children and determine the prevalence and risk factors for dyslipidaemia and hyperglycaemia, which are risk factors for cardiovascular diseases. METHODS: This was a comparative cross-sectional study carried out at the Paediatric Infectious Disease Clinic (PIDC) of the Jos University Teaching Hospital (JUTH) for HIV-positive children and at two primary schools in Jos for HIV-negative children as controls...
July 1, 2017: Journal of Virus Eradication
https://www.readbyqxmd.com/read/28758023/strategies-to-improve-the-uptake-of-effective-contraception-in-perinatally-hiv-infected-adolescents
#5
EDITORIAL
Nadia Kancheva Landolt, Jullapong Achalapong, Pope Kosalaraksa, Witaya Petdachai, Chaiwat Ngampiyaskul, Stephen Kerr, Pongrak Boonyanurak, Jintanat Ananworanich, Torsak Bunupuradah
OBJECTIVE: To assess strategies to improve safe-sex practices in sexually active female adolescents living with HIV, through linking reproductive health (RH) care with HIV care. METHODS: A single arm, 48-week prospective study was conducted with 77 sexually active adolescents in five sites in Thailand. Guided RH education was carried out through video, brochures and individual counselling. Participants were offered free effective contraception (EC), in addition to a barrier method (dual contraception) versus barrier method only...
July 1, 2017: Journal of Virus Eradication
https://www.readbyqxmd.com/read/28758022/factors-associated-with-early-menopause-among-women-in-nigeria
#6
EDITORIAL
Patricia Agaba, Seema Meloni, Halima Sule, Amaka Ocheke, Emmanuel Agaba, John Idoko, Phyllis Kanki
OBJECTIVES: Effective antiretroviral therapy has prolonged the survival of patients with HIV. Accordingly, studies of the consequences of ageing are increasingly important. We determined the prevalence of early menopause (EM) and its associated factors in a cohort of HIV-infected and HIV-negative controls in Jos, Nigeria. METHODS: HIV-infected women accessing care in an ambulatory setting and their negative counterparts from the general population were included...
July 1, 2017: Journal of Virus Eradication
https://www.readbyqxmd.com/read/28758021/hiv-disclosure-and-stigma-among-women-living-with-hiv-in-denmark
#7
EDITORIAL
Maria Wessman, Kristina Thorsteinsson, Merete Storgaard, Frederikke F Rönsholt, Isik S Johansen, Gitte Pedersen, Lars N Nielsen, Nina Wies, Terese L Katzenstein, Anne-Mette Lebech
OBJECTIVE: To identify disclosure, stigma and predictors of non-disclosure among women living with HIV in Denmark. METHODS: A questionnaire study of women living with HIV in Denmark was performed. The enrolment period was from February 2013 to March 2014. Logistic regression was used to estimate predictors of non-disclosure. RESULTS: A total of 234 participants were included. The majority (94%) had disclosed their HIV status to at least one person outside their healthcare environment, although 29% had disclosed to fewer than three people...
July 1, 2017: Journal of Virus Eradication
https://www.readbyqxmd.com/read/28758020/factors-associated-with-intention-to-take-non-occupational-hiv-post-exposure-prophylaxis-among-thai-men-who-have-sex-with-men
#8
EDITORIAL
Nitiya Chomchey, Thira Woratanarat, Narin Hiransuthikul, Somrat Lertmaharit, Vitool Lohsoonthorn, Nipat Teeratakulpisarn, Suteeraporn Pinyakorn, James Lk Fletcher, Duanghathai Suttichom, Praphan Phanuphak, Jintanat Ananworanich, Nittaya Phanuphak
BACKGROUND: Men who have sex with men (MSM) are disproportionately infected with HIV in Thailand. Factors affecting their intention to take non-occupational HIV post-exposure prophylaxis (nPEP) are not well understood. This study sought to determine factors associated with an intention to take nPEP in this population. METHOD: This is a two-phase mixed-method study. Phase I was a cross-sectional survey of intention to take nPEP in 450 MSM attending for HIV testing, using a self-administered questionnaire...
July 1, 2017: Journal of Virus Eradication
https://www.readbyqxmd.com/read/28758019/current-trends-in-zika-vaccine-development
#9
EDITORIAL
Francisco A Lagunas-Rangel, Martha E Viveros-Sandoval, Arturo Reyes-Sandoval
The Zika virus (ZIKV) was first isolated in 1947 in Uganda. While it took 60 years for this virus to cause major outbreaks, an important shift in its ability to cause epidemics took place in the first and second decades of the this century: in 2007 in Yap Island, Micronesia, followed by French Polynesia in 2013 and, finally in 2015 and 2016, when ZIKV infections occurred throughout South America, Central America and the Caribbean, spreading rapidly to reach North America in just a single year. No licensed prophylactic vaccine is yet available but recent efforts towards the development of a vaccine have been remarkable from both the private and public sectors and include new candidate vaccines ranging from the classical live-attenuated or inactivated vaccines to more sophisticated approaches such as mRNA or genetically engineered viral platforms...
July 1, 2017: Journal of Virus Eradication
https://www.readbyqxmd.com/read/28758018/the-road-to-elimination-of-hepatitis-c-analysis-of-cures-versus-new-infections-in-91-countries
#10
EDITORIAL
Andrew M Hill, Sanjay Nath, Bryony Simmons
BACKGROUND: Hepatitis C (HCV) can only be eradicated if annual rates of cure (SVR) are consistently and significantly higher than new HCV infections, across many countries. In 2016, the WHO called for a 90% reduction in new HCV infection by 2030. Direct-acting antivirals (DAA) can cure the majority of those treated, at around 90% in most populations, at potentially very low prices. We compared the net annual change in epidemic size across 91 countries using data on SVR, new HCV infections, and deaths...
July 1, 2017: Journal of Virus Eradication
https://www.readbyqxmd.com/read/28758017/towards-an-ideal-antiretroviral-regimen-for-the-global-hiv-epidemic
#11
EDITORIAL
Beatriz Grinsztejn, Lara E Coelho, Paula M Luz, Valdilea G Veloso
Currently, immediate initiation of antiretroviral therapy (ART) is recommended for all individuals with HIV infection. However, among the 37 million people estimated to be living with HIV/AIDS, only 17 million are actively on treatment. Optimal use of ART among HIV-infected and at-risk individuals reduces morbidity, mortality, transmission and acquisition of HIV infection. ART regimen choices are affected by factors such as economic differences between resource-rich and low- and middle-income countries (LIMC), drug availability, and considerations for use in special populations...
July 1, 2017: Journal of Virus Eradication
https://www.readbyqxmd.com/read/28435696/highlights-from-the-24-th-conference-on-retroviruses-and-opportunistic-infections-13-16-february-2017-seattle-washington-usa
#12
EDITORIAL
Trevor A Crowell, Hermione Lyall, Eva Malatinkova, Sanjay Bhagani, Denise Hsu, Donn J Colby, Christina Polyak, Christina Psomas, Andrew Hill, Esther N Gathogo, Wim Trypsteen, Linos Vandekerckhove, Sabine Kinloch
From the 13th to 16th February 2017, researchers from around the world convened for the 24th annual Conference on Retroviruses and Opportunistic Infections (CROI) at the Washington State Convention Center in Seattle, Washington. The conference was organised by the International Antiviral Society-USA (IAS-USA) in partnership with the CROI Foundation. The conference included over 1000 oral and poster presentations of peer-reviewed original research as well as lectures and symposia featuring insights from leading basic, translational and clinical researchers...
April 1, 2017: Journal of Virus Eradication
https://www.readbyqxmd.com/read/28435695/highlights-of-the-international-congress-on-drug-therapy-in-hiv-infection-23-26-october-2016-glasgow-uk
#13
EDITORIAL
Julio Montaner, Pablo Rojo, Tarandeep Anand, Jürgen Rockstroh
No abstract text is available yet for this article.
April 1, 2017: Journal of Virus Eradication
https://www.readbyqxmd.com/read/28435694/highlights-from-the-hiv-research-for-prevention-conference-r4p-17-21-october-2016-chicago-il-usa
#14
EDITORIAL
Sandhya Vasan, Tanyaporn Wansom, Alexandra Schuetz, Shelly Krebs, Rasmi Thomas, Gustavao Kijak, Christina Polyak
No abstract text is available yet for this article.
April 1, 2017: Journal of Virus Eradication
https://www.readbyqxmd.com/read/28435693/the-post-condom-era-or-the-urgent-need-to-provide-effective-contraception-for-women-living-with-hiv
#15
EDITORIAL
Karoline Aebi-Popp
No abstract text is available yet for this article.
April 1, 2017: Journal of Virus Eradication
https://www.readbyqxmd.com/read/28435692/a-cd3-cd28-microbead-based-hiv-1-viral-outgrowth-assay
#16
EDITORIAL
Yury V Kuzmichev, Rebecca T Veenhuis, Christopher W Pohlmeyer, Caroline C Garliss, Victoria Ek Walker-Sperling, Joel N Blankson
AIMS: Latently infected resting CD4 T cells represent a major barrier to HIV-1 eradication efforts. The standard assays used for measuring this reservoir induce activation of resting CD4 T cells with either phytohaemagglutinin (PHA) with irradiated feeder cells, or with anti-CD3 antibodies. We designed a study to compare the sensitivity of a new assay (based on the stimulation of CD4 T cells with anti-CD3 and anti-CD28 coated microbeads) with that of the traditional PHA- and feeder-based viral outgrowth assay...
April 1, 2017: Journal of Virus Eradication
https://www.readbyqxmd.com/read/28435691/interrupting-antiretroviral-treatment-in-hiv-cure-research-scientific-and-ethical-considerations
#17
EDITORIAL
Samual A Garner, Stuart Rennie, Jintanat Ananworanich, Karine Dube, David M Margolis, Jeremy Sugarman, Randall Tressler, Adam Gilbertson, Liza Dawson
Over the past several years there has been intense activity directed at the possibility of achieving remission or eradication of HIV infection. Current assays for the measurement of latent HIV are insufficient to demonstrate complete clearance of replication-competent HIV. Therefore, the ultimate test for assessing whether investigational interventions have resulted in HIV remission or eradication is to interrupt standard antiretroviral therapy (ART) in a carefully controlled clinical trial setting. These procedures, known as analytic treatment interruptions (ATIs), raise important scientific and ethical questions...
April 1, 2017: Journal of Virus Eradication
https://www.readbyqxmd.com/read/28435690/the-complex-legal-and-ethical-issues-related-to-generic-medications-viral-hepatitis-a-case-study
#18
EDITORIAL
M Danta, N Ghinea
The economic impact of medications is significant, with many countries unable to afford the essential medicines listed by the WHO. Generic medications are one strategy to address this issue. Generic medications are similar to but not the same as originator medications. They have a significant cost advantage because they do not require the background research and development studies to support registration. Consequently, they are gaining increased market share in both the developed and developing world. Many new medications are now licensed to generic manufacturers in the developing world...
April 1, 2017: Journal of Virus Eradication
https://www.readbyqxmd.com/read/28275462/highlights-from-the-third-biennial-strategies-for-an-hiv-cure-meeting-14-16-november-2016-bethesda-md-usa
#19
EDITORIAL
Diane Lawrence, Lillian Kuo, Elizabeth Church, Betty Poon, Stephen Smiley, Brigitte Sanders-Beer, Liza Dawson, Karl Salzwedel
Since the first Strategies for an HIV Cure Meeting organised by the National Institute of Allergy and Infectious Diseases (NIAID) in 2012, one of the primary purposes of the meeting has been to facilitate communication and foster collaboration across the NIAID-funded Martin Delaney Collaboratories for HIV cure research (MDC), the broader HIV cure-related research field, and industry and community stakeholders. This year's meeting agenda reflected NIAID's increasing investment over the last 5 years in research to identify strategies for eradicating or achieving long-term remission of HIV infection...
January 1, 2017: Journal of Virus Eradication
https://www.readbyqxmd.com/read/28275461/hiv-reservoir-characterization-symposium-19-september-2016-ghent-belgium
#20
EDITORIAL
Eva Malatinkova, Ward De Spiegelaere, Linos Vandekerckhove, Magdalena Sips
The HIV Cure Research Center (HCRC) in Ghent organised the first HIV Reservoir Characterization Symposium, and brought together virologists, molecular biologists, immunologists and clinicians to discuss the most recent developments in HIV reservoir characterisation with a view to achieving an HIV cure. The one-day symposium covered new developments in the field of HIV reservoir and HIV cure research, with the latest news on the European HIV cure trials. This report summarises the major themes discussed during the symposium...
January 1, 2017: Journal of Virus Eradication
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