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Drug Metabolism and Personalized Therapy

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https://www.readbyqxmd.com/read/30414364/effect-of-baseline-renal-and-hepatic-function-on-the-incidence-of-adverse-drug-events-the-japan-adverse-drug-events-study
#1
Yuri Takahashi, Mio Sakuma, Hiroki Murayama, Takeshi Morimoto
Background The impact of renal and hepatic dysfunction on the morbidity and mortality of inpatients with adverse drug events (ADEs) is uncertain in daily clinical practice. The objective of this study was to investigate the effect of renal and hepatic function on ADEs and inpatients' morbidity and mortality. Methods The Japan Adverse Drug Events (JADE) study was a prospective cohort study carried out at three tertiary-care teaching hospitals in Japan. Participants were consecutive inpatients (n=3459) aged 15 years or older...
November 10, 2018: Drug Metabolism and Personalized Therapy
https://www.readbyqxmd.com/read/30391933/personalized-medicine-into-health-national-services-barriers-and-potentialities
#2
Ana E Rodríguez Vicente, Maria José Herrero Cervera, María Luisa Bernal, Luis Rojas, Ana M Peiró
Research and innovation in personalized medicine (PM) are extensive and expanding, with several pharmacogenetic/pharmacogenomic (PGx) testing options currently available for a wide range of health problems. However, PGx-guided therapy faces many barriers to full integration into clinical practice and acceptance by practitioner/patient: utilization and uptake by payers in real-world practice are being discussed, and the criteria to guide clinicians and policy makers in PGx test selection are not fully incorporated...
November 3, 2018: Drug Metabolism and Personalized Therapy
https://www.readbyqxmd.com/read/30325732/effects-of-cyp2c19-17-polymorphisms-on-the-efficacy-and-safety-of-bromodigyrochlorophenylbenzodiazepine-in-patients-with-anxiety-disorder-and-comorbid-alcohol-use-disorder
#3
Michael S Zastrozhin, Anastasiya P Antonenko, Elena V Nesterenko, Leyla I Seyfullaeva, Violetta R Mustafina, Antonina P Esakova, Elena A Grishina, Alexandr S Sorokin, Valentin Yu Skryabin, Ludmila M Savchenko, Evgeny A Bryun, Dmitry A Sychev
Background Bromodihydrochlorophenylbenzodiazepine (Phenazepam®) is used in the therapy of anxiety disorders in patients with alcohol dependence. However, Phenazepam therapy often turns out to be ineffective, and some patients develop dose-related adverse drug reactions (ADR): severe sedation, dizziness, headache, dyspepsia, falling, etc. That ensures the effectiveness of this category of patients. Despite the popularity of Phenazepam® as an anxiolytic drug, there is currently no accurate data on its biotransformation, as well as the effect of polymorphism of a gene on the efficacy and safety of bromodihydrochlorophenylbenzodiazepine in patients...
October 16, 2018: Drug Metabolism and Personalized Therapy
https://www.readbyqxmd.com/read/30325731/pharmacogenetic-testing-by-polymorphic-markers-g1846a-cyp2d6-4-and-c100t-cyp2d6-10-of-the-cyp2d6-gene-in-coronary-heart-disease-patients-taking-%C3%AE-%C3%AE-blockers-in-the-republic-of-sakha-yakutia
#4
Denis S Fedorinov, Karin B Mirzaev, Violetta R Mustafina, Dmitriy A Sychev, Nadezda R Maximova, Jana V Chertovskikh, Nyurguiana V Popova, Sardana M Tarabukina, Zoya A Rudykh
Background The aim of this study was to determine carrier frequencies of the polymorphic markers G1846A (CYP2D6*4) and C100T (CYP2D6*10) of the CYP2D6 gene in coronary heart disease (CHD) patients in Russian and Yakut ethnic groups. The association between the administration of higher doses of bisoprolol and metoprolol and the carriage of these polymorphic markers related to the decreased function of the haplotype of CYP2D6 was also studied. Methods The study included 201 CHD patients (aged 66±8.7 years) receiving metoprolol in titrated dose (12...
October 16, 2018: Drug Metabolism and Personalized Therapy
https://www.readbyqxmd.com/read/30207288/early-disease-relapse-in-a-patient-with-colorectal-cancer-who-harbors-genetic-variants-of-dpyd-tyms-mthfr-and-dhfr-after-treatment-with-5-fluorouracil-based-chemotherapy
#5
Mohammed Zawiah, Al-Motassem Yousef, Taha Kadi, Mohammed Yousef, Khalil Majdalawi, Shorouq Al-Yacoub, Rasha Al-Hiary, Dua'a Tantawi, Ramzi Mukred, Abdel Rahman Ajaj
Background Early relapse in colorectal cancer (CRC) after curative resection is mainly attributed to the key determinants such as tumor histology, stage, lymphovascular invasion, and the response to chemotherapy. Case presentation Interindividual variability in the efficacy of adjuvant chemotherapy between patients receiving the same treatment may be ascribed to the patients' genetic profile. In this report, we highlight a clinical case of a patient with stage II CRC who relapsed within a short period after starting adjuvant chemotherapy and was later found to have multiple genetic polymorphisms in the DPYD, TYMS, MTHFR, and DHFR genes...
September 12, 2018: Drug Metabolism and Personalized Therapy
https://www.readbyqxmd.com/read/30171809/the-abcb1-cyp2c19-cyp3a5-and-cyp4f2-genetic-polymorphisms-and-platelet-reactivity-in-the-early-phases-of-acute-coronary-syndromes
#6
Karin B Mirzaev, Eric Rytkin, Kristina A Ryzhikova, Elena A Grishina, Zhannet A Sozaeva, Denis S Fedorinov, Olga D Konova, Michael Iu Giliarov, Galina A Belyakova, Denis A Andreev, Dmitriy A Sychev
No abstract text is available yet for this article.
September 25, 2018: Drug Metabolism and Personalized Therapy
https://www.readbyqxmd.com/read/30145579/complex-method-for-calculating-total-serum-calcium-concentration
#7
Natalia N Eremenko, Eugenia V Shikh, Svetlana Y Serebrova
No abstract text is available yet for this article.
September 25, 2018: Drug Metabolism and Personalized Therapy
https://www.readbyqxmd.com/read/30098282/simvastatin-related-myopathy-in-shift-workers-a-report-of-two-cases
#8
Saul Flores-Unzueta, Martha Sosa-Macias, Laurence A Marchat, Ismael Lares-Assef, Omar Carrasco-Ortega, Miguel Correa-Ramirez, Fernando Guerrero-Romero, Carlos Galaviz-Hernandez
No abstract text is available yet for this article.
September 25, 2018: Drug Metabolism and Personalized Therapy
https://www.readbyqxmd.com/read/30098281/distribution-of-cyp2d6-genotypes-in-the-indian-population-preliminary-report
#9
Minal U Paradkar, Swarup A V Shah, Alpa J Dherai, Dhanashri Shetty, Tester F Ashavaid
No abstract text is available yet for this article.
September 25, 2018: Drug Metabolism and Personalized Therapy
https://www.readbyqxmd.com/read/30070095/assessment-of-cyp2d6-re-activation-after-inhibitory-effect-of-mdma-using-tramadol-as-a-probe
#10
Shahin Nilchi, Davood Behdarvand, Hoda Lavasani, Mohammadreza Rouini, Yalda H Ardakani
No abstract text is available yet for this article.
September 25, 2018: Drug Metabolism and Personalized Therapy
https://www.readbyqxmd.com/read/29813026/exploring-the-role-of-defective-fibronectin-matrix-assembly-in-the-vhl-associated-cns-hemangioblastoma
#11
Narendranath Vikkath, Prasanth Ariyannur, Krishnakumar N Menon, Bindhu Mr, Ashok Pillai
No abstract text is available yet for this article.
September 25, 2018: Drug Metabolism and Personalized Therapy
https://www.readbyqxmd.com/read/29738309/pharmacogenetic-testing-by-polymorphic-markers-681g-a-and-636g-a-cyp2c19-gene-in-patients-with-acute-coronary-syndrome-and-gastric-ulcer-in-the-republic-of-sakha-yakutia
#12
Denis S Fedorinov, Karin B Mirzaev, Dmitriy V Ivashchenko, Ilyas I Temirbulatov, Dmitriy A Sychev, Nadezda R Maksimova, Jana V Chertovskih, Nyurguiana V Popova, Ksenia S Tayurskaya, Zoya A Rudykh
BACKGROUND: The focus of the study is to determine the prevalence of CYP2C19 alleles, associated with the risk of changes in the pharmacological response to clopidogrel and proton pump inhibitors in patients with acute coronary syndrome (ACS) and gastric ulcer from Russian and Yakut ethnic groups. METHODS: The research included 411 patients with ACS (143 Russians and 268 Yakuts) and 204 patients with histologically confirmed gastric ulcer (63 Russians and 141 Yakuts)...
June 27, 2018: Drug Metabolism and Personalized Therapy
https://www.readbyqxmd.com/read/29727299/correlation-between-plasma-concentrations-of-tramadol-and-its-metabolites-and-the-incidence-of-seizure-in-tramadol-intoxicated-patients
#13
Mahnaz Ahmadimanesh, Shahin Shadnia, Mohammad Reza Rouini, Behjat Sheikholeslami, Sara Ahsani Nasab, Mahmoud Ghazi-Khansari
BACKGROUND: Seizure is one of the important symptoms of tramadol poisoning, but its causes are still unknown. The aim of this study is to find a relationship between tramadol and the concentrations of its metabolites versus the incidence of seizures following the consumption of high doses of tramadol. METHODS: For this purpose, the blood samples of 120 tramadol-intoxicated patients were collected. The patients were divided in two groups (seizure and non-seizure)...
June 27, 2018: Drug Metabolism and Personalized Therapy
https://www.readbyqxmd.com/read/29727298/which-cytochrome-p450-metabolizes-phenazepam-step-by-step-in-silico-in-vitro-and-in-vivo-studies
#14
Dmitriy V Ivashchenko, Anastasia V Rudik, Andrey A Poloznikov, Sergey V Nikulin, Valeriy V Smirnov, Alexander G Tonevitsky, Eugeniy A Bryun, Dmitriy A Sychev
BACKGROUND: Phenazepam (bromdihydrochlorphenylbenzodiazepine) is the original Russian benzodiazepine tranquilizer belonging to 1,4-benzodiazepines. There is still limited knowledge about phenazepam's metabolic liver pathways and other pharmacokinetic features. METHODS: To determine phenazepam's metabolic pathways, the study was divided into three stages: in silico modeling, in vitro experiment (cell culture study), and in vivo confirmation. In silico modeling was performed on the specialized software PASS and GUSAR to evaluate phenazepam molecule affinity to different cytochromes...
June 27, 2018: Drug Metabolism and Personalized Therapy
https://www.readbyqxmd.com/read/29715182/remission-of-relapsing-polychondritis-after-successful-treatment-of-myelodysplastic-syndrome-with-azacitidine-a-case-and-review-of-the-literature
#15
Abdulsamet Erden, Emre Bilgin, Levent Kılıç, Alper Sarı, Berkan Armağan, Yahya Büyükaşık, Umut Kalyoncu
BACKGROUND: Relapsing polychondritis (RP) is a rare autoimmune disorder, and myelodysplastic syndrome (MDS) is accompanied by RP at variable rates. Herein, we report a case with RP and MDS who responded dramatically to 5-azacitidine for MDS. CASE PRESENTATION: With conventional immunosuppressive treatment, our patient had several episodes of different side effects, including infections. With the diagnosis of MDS and initiation of azacitidine treatment, all the manifestations of RP disappeared, and remission was achieved for MDS...
June 27, 2018: Drug Metabolism and Personalized Therapy
https://www.readbyqxmd.com/read/29688886/new-perspectives-in-personalised-medicine-for-ethnicity-in-cancer-population-pharmacogenomics-and-pharmacometrics
#16
EDITORIAL
Sujit Nair, Adrián LLerena
No abstract text is available yet for this article.
June 27, 2018: Drug Metabolism and Personalized Therapy
https://www.readbyqxmd.com/read/29624501/effect-of-the-african-specific-promoter-polymorphisms-on-the-slc22a2-gene-expression-levels
#17
Brendon Pearce, Zainonesa Abrahams-October, Lettilia Xhakaza, Clifford Jacobs, Mongi Benjeddou
BACKGROUND: Single nucleotide polymorphisms in promoter regions have been shown to alter the transcription of genes. Thus, SNPs in SLC22A2 can result in inter-individual variable response to medication. METHODS: The objective of the study was to investigate the effect of the African-specific promoter polymorphisms on the SLC22A2 gene expression levels in vitro. These included rs572296424 and rs150063153, which have been previously identified in the Xhosa population of South Africa...
June 27, 2018: Drug Metabolism and Personalized Therapy
https://www.readbyqxmd.com/read/29624500/homocysteine-is-the-confounding-factor-of-metabolic-syndrome-confirmed-by-sims-score
#18
Branko Srećković, Ivan Soldatovic, Emina Colak, Igor Mrdovic, Mirjana Sumarac-Dumanovic, Hristina Janeski, Nenad Janeski, Jasna Gacic, Vesna Dimitrijevic-Sreckovic
BACKGROUND: Abdominal adiposity has a central role in developing insulin resistance (IR) by releasing pro-inflammatory cytokines. Patients with metabolic syndrome (MS) have higher values of homocysteine. Hyperhomocysteinemia correlates with IR, increasing the oxidative stress. Oxidative stress causes endothelial dysfunction, hypertension and atherosclerosis. The objective of the study was to examine the correlation of homocysteine with siMS score and siMS risk score and with other MS co-founding factors...
June 27, 2018: Drug Metabolism and Personalized Therapy
https://www.readbyqxmd.com/read/29537211/metabolism-and-mechanisms-of-action-of-hyaluronan-in-human-biology
#19
REVIEW
Reenu Anne Joy, Narendranath Vikkath, Prasanth S Ariyannur
Hyaluronan is a ubiquitous high-molecular weight polymer of repeated disaccharides of glucuronic acid and N-acetylglucosamine. It is a membrane-bound, viscous material extruded into the extracellular matrix after being synthesized in the cytoplasm by hyaluronan synthases complex and a regulated degradation by a group of enzymes called hyaluronidases. Hyaluronan has varied biological roles on many vital organismal functions, such as cellular and tissue development, migration and repair after injury or inflammation and cancer genesis...
March 28, 2018: Drug Metabolism and Personalized Therapy
https://www.readbyqxmd.com/read/29470173/preemptive-nudt15-genotyping-redefining-the-management-of-patients-with-thiopurine-induced-toxicity
#20
Swarup A V Shah, Minal U Paradkar, Devendra C Desai, Tester F Ashavaid
BACKGROUND: Thiopurine methyltransferase (TPMT) gene variants have achieved limited success in predicting the outcome of thiopurine therapy, which shows wide inter-individual variations. The literature indicates a strong association between the NUDT15 gene variant and thiopurine-induced toxicity in Asian patients. The present study intends to explore the role of the NUDT15 variant (C415T) in Indian patients on thiopurine therapy. METHODS: NUDT15 and TPMT genotyping were performed using amplification-refractory mutation system-polymerase chain reaction (ARMS-PCR) and the restriction fragment length polymorphism (RFLP) technique...
March 28, 2018: Drug Metabolism and Personalized Therapy
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