journal
MENU ▼
Read by QxMD icon Read
search

Frontiers in Molecular Biosciences

journal
https://www.readbyqxmd.com/read/29774215/importance-of-functional-loss-of-fus-in-ftld-als
#1
REVIEW
Shinsuke Ishigaki, Gen Sobue
Fused in sarcoma (FUS) is an RNA binding protein that regulates RNA metabolism including alternative splicing, transcription, and RNA transportation. FUS is genetically and pathologically involved in frontotemporal lobar degeneration (FTLD)/amyotrophic lateral sclerosis (ALS). Multiple lines of evidence across diverse models suggest that functional loss of FUS can lead to neuronal dysfunction and/or neuronal cell death. Loss of FUS in the nucleus can impair alternative splicing and/or transcription, whereas dysfunction of FUS in the cytoplasm, especially in the dendritic spines of neurons, can cause mRNA destabilization...
2018: Frontiers in Molecular Biosciences
https://www.readbyqxmd.com/read/29774214/the-expression-of-aqp1-is-modified-in-lung-of-patients-with-idiopathic-pulmonary-fibrosis-addressing-a-possible-new-target
#2
Ana Galán-Cobo, Elena Arellano-Orden, Rocío Sánchez Silva, José Luis López-Campos, César Gutiérrez Rivera, Lourdes Gómez Izquierdo, Nela Suárez-Luna, María Molina-Molina, José A Rodríguez Portal, Miriam Echevarría
Activation of the epithelial-mesenchymal transition process (EMT) by which alveolar cells in human lung tissue undergo differentiation giving rise to a mesenchymal phenotype (fibroblast/miofibroblasts) has been well recognized as a key element in the origin of idiopathic pulmonary fibrosis (IPF). Here we analyzed expression of AQP1 in lung biopsies of patients diagnosed with IPF, and compared it to biopsies derived from patients with diverse lung pneumonies, such as hypersensitivity pneumonitis, sarcoidosis or normal lungs...
2018: Frontiers in Molecular Biosciences
https://www.readbyqxmd.com/read/29761107/intramolecular-fuzzy-interactions-involving-intrinsically-disordered-domains
#3
REVIEW
Miguel Arbesú, Guillermo Iruela, Héctor Fuentes, João M C Teixeira, Miquel Pons
Structural disorder is an essential ingredient for function in many proteins and protein complexes. Fuzzy complexes describe the many instances where disorder is maintained as a critical element of protein interactions. In this minireview we discuss how intramolecular fuzzy interactions function in signaling complexes. Focussing on the Src family of kinases, we argue that the intrinsically disordered domains that are unique for each of the family members and display a clear fingerprint of long range interactions in Src, might have critical roles as functional sensor or effectors and mediate allosteric communication via fuzzy interactions...
2018: Frontiers in Molecular Biosciences
https://www.readbyqxmd.com/read/29755985/single-ring-intermediates-are-essential-for-some-chaperonins
#4
Jay M Bhatt, Adrian S Enriquez, Jinliang Wang, Humberto M Rojo, Sudheer K Molugu, Zacariah L Hildenbrand, Ricardo A Bernal
Chaperonins are macromolecular complexes found throughout all kingdoms of life that assist unfolded proteins reach a biologically active state. Historically, chaperonins have been classified into two groups based on sequence, subunit structure, and the requirement for a co-chaperonin. Here, we present a brief review of chaperonins that can form double- and single-ring conformational intermediates in their protein-folding catalytic pathway. To date, the bacteriophage encoded chaperonins ϕ-EL and OBP, human mitochondrial chaperonin and most recently, the bacterial groEL/ES systems, have been reported to form single-ring intermediates as part of their normal protein-folding activity...
2018: Frontiers in Molecular Biosciences
https://www.readbyqxmd.com/read/29732373/toward-developing-chemical-modulators-of-hsp60-as-potential-therapeutics
#5
REVIEW
Qianli Meng, Bingbing X Li, Xiangshu Xiao
The 60 kDa heat shock protein (Hsp60) is classically known as a mitochondrial chaperonin protein working together with co-chaperonin 10 kDa heat shock protein (Hsp10). This chaperonin complex is essential for folding proteins newly imported into mitochondria. However, Hsp60, and/or Hsp10 have also been shown to reside in other subcellular compartments including extracellular space, cytosol, and nucleus. The proteins in these extra-mitochondrial compartments may possess a wide range of functions dependent or independent of its chaperoning activity...
2018: Frontiers in Molecular Biosciences
https://www.readbyqxmd.com/read/29725596/substrate-specificity-of-cysteine-proteases-beyond-the-s-2-pocket-mutagenesis-and-molecular-dynamics-investigation-of-fasciola-hepatica-cathepsins-l
#6
Ileana Corvo, Florencia Ferraro, Alicia Merlino, Kathrin Zuberbühler, Anthony J O'Donoghue, Lucía Pastro, Natalia Pi-Denis, Tatiana Basika, Leda Roche, James H McKerrow, Charles S Craik, Conor R Caffrey, José F Tort
Cysteine proteases are widespread in all life kingdoms, being central to diverse physiological processes based on a broad range of substrate specificity. Paralogous Fasciola hepatica cathepsin L proteases are essential to parasite invasion, tissue migration and reproduction. In spite of similarities in their overall sequence and structure, these enzymes often exhibit different substrate specificity. These preferences are principally determined by the amino acid composition of the active site's S2 subsite (pocket) of the enzyme that interacts with the substrate P2 residue (Schetcher and Berger nomenclature)...
2018: Frontiers in Molecular Biosciences
https://www.readbyqxmd.com/read/29725595/stabilization-of-a-membrane-associated-amyloid-%C3%AE-oligomer-for-its-validation-in-alzheimer-s-disease
#7
Montserrat Serra-Batiste, James Tolchard, Fabrice Giusti, Manuela Zoonens, Natàlia Carulla
We have recently reported on the preparation of a membrane-associated β -barrel Pore-Forming Aβ42 Oligomer (β PFO Aβ 42 ). It corresponds to a stable and homogeneous Aβ42 oligomer that inserts into lipid bilayers as a well-defined pore and adopts a specific structure with characteristics of a β-barrel arrangement. As a follow-up of this work, we aim to establish β PFO Aβ 42 's relevance in Alzheimer's disease (AD). However, β PFO Aβ 42 is formed under dodecyl phosphocholine (DPC) micelle conditions-intended to mimic the hydrophobic environment of membranes-which are dynamic...
2018: Frontiers in Molecular Biosciences
https://www.readbyqxmd.com/read/29721498/aquaporins-as-targets-of-dietary-bioactive-phytocompounds
#8
REVIEW
Angela Tesse, Elena Grossini, Grazia Tamma, Catherine Brenner, Piero Portincasa, Raul A Marinelli, Giuseppe Calamita
Plant-derived bioactive compounds have protective role for plants but may also modulate several physiological processes of plant consumers. In the last years, a wide spectrum of phytochemicals have been found to be beneficial to health interacting with molecular signaling pathways underlying critical functions such as cell growth and differentiation, apoptosis, autophagy, inflammation, redox balance, cell volume regulation, metabolic homeostasis, and energy balance. Hence, a large number of biologically active phytocompounds of foods have been isolated, characterized, and eventually modified representing a natural source of novel molecules to prevent, delay or cure several human diseases...
2018: Frontiers in Molecular Biosciences
https://www.readbyqxmd.com/read/29713633/two-family-b-dna-polymerases-from-aeropyrum-pernix-based-on-revised-translational-frames
#9
Katsuya Daimon, Sonoko Ishino, Namiko Imai, Sachiyo Nagumo, Takeshi Yamagami, Hiroaki Matsukawa, Yoshizumi Ishino
Living organisms are divided into three domains, Bacteria, Eukarya, and Archaea. Comparative studies in the three domains have provided useful information to understand the evolution of the DNA replication machinery. DNA polymerase is the central enzyme of DNA replication. The presence of multiple family B DNA polymerases is unique in Crenarchaeota, as compared with other archaeal phyla, which have a single enzyme each for family B (PolB) and family D (PolD). We analyzed PolB1 and PolB3 in the hyperthermophilic crenarchaeon, Aeropyrum pernix , and found that they are larger proteins than those predicted from the coding regions in our previous study and from public database annotations...
2018: Frontiers in Molecular Biosciences
https://www.readbyqxmd.com/read/29707543/modeling-based-investigation-of-the-effect-of-noise-in-cellular-systems
#10
REVIEW
Didier Gonze, Claude Gérard, Benjamin Wacquier, Aurore Woller, Alen Tosenberger, Albert Goldbeter, Geneviève Dupont
Noise is pervasive in cellular biology and inevitably affects the dynamics of cellular processes. Biological systems have developed regulatory mechanisms to ensure robustness with respect to noise or to take advantage of stochasticity. We review here, through a couple of selected examples, some insights on possible robustness factors and constructive roles of noise provided by computational modeling. In particular, we focus on (1) factors that likely contribute to the robustness of oscillatory processes such as the circadian clocks and the cell cycle, (2) how reliable coding/decoding of calcium-mediated signaling could be achieved in presence of noise and, in some cases, enhanced through stochastic resonance, and (3) how embryonic cell differentiation processes can exploit stochasticity to create heterogeneity in a population of identical cells...
2018: Frontiers in Molecular Biosciences
https://www.readbyqxmd.com/read/29696147/drug-interactions-with-the-ca-2-atpase-from-sarco-endo-plasmic-reticulum-serca
#11
REVIEW
Francesco Tadini-Buoninsegni, Serena Smeazzetto, Roberta Gualdani, Maria Rosa Moncelli
The sarco(endo)plasmic reticulum Ca2+ -ATPase (SERCA) is an intracellular membrane transporter that utilizes the free energy provided by ATP hydrolysis for active transport of Ca2+ ions from the cytoplasm to the lumen of sarco(endo)plasmic reticulum. SERCA plays a fundamental role for cell calcium homeostasis and signaling in muscle cells and also in cells of other tissues. Because of its prominent role in many physiological processes, SERCA dysfunction is associated to diseases displaying various degrees of severity...
2018: Frontiers in Molecular Biosciences
https://www.readbyqxmd.com/read/29696146/the-use-of-nmr-to-study-transient-carbohydrate-protein-interactions
#12
REVIEW
Pedro M Nieto
Carbohydrates are biologically ubiquitous and are essential to the existence of all known living organisms. Although they are better known for their role as energy sources (glucose/glycogen or starch) or structural elements (chitin or cellulose), carbohydrates also participate in the recognition events of molecular recognition processes. Such interactions with other biomolecules (nucleic acids, proteins, and lipids) are fundamental to life and disease. This review focuses on the application of NMR methods to understand at the atomic level the mechanisms by which sugar molecules can be recognized by proteins to form complexes, creating new entities with different properties to those of the individual component molecules...
2018: Frontiers in Molecular Biosciences
https://www.readbyqxmd.com/read/29696145/a-glimpse-into-the-structure-and-function-of-atypical-type-i-chaperonins
#13
REVIEW
Mohammed Y Ansari, Shekhar C Mande
Chaperonins are a subclass of molecular chaperones that assist cellular proteins to fold and assemble into their native shape. Much work has been done on Type I chaperonins, which has elucidated their elegant mechanism. Some debate remains about the details in these mechanisms, but nonetheless the roles of these in helping protein folding have been understood in great depth. In this review we discuss the known functions of atypical Type I chaperonins, highlighting evolutionary aspects that might lead chaperonins to perform alternate functions...
2018: Frontiers in Molecular Biosciences
https://www.readbyqxmd.com/read/29686991/metabolic-biomarkers-of-ageing-in-c57bl-6j-wild-type-and-flavin-containing-monooxygenase-5-fmo5-knockout-mice
#14
Dorsa Varshavi, Flora H Scott, Dorna Varshavi, Sunil Veeravalli, Ian R Phillips, Kirill Veselkov, Nicole Strittmatter, Zoltan Takats, Elizabeth A Shephard, Jeremy R Everett
It was recently demonstrated in mice that knockout of the flavin-containing monooxygenase 5 gene, Fmo5 , slows metabolic ageing via pleiotropic effects. We have now used an NMR-based metabonomics approach to study the effects of ageing directly on the metabolic profiles of urine and plasma from male, wild-type C57BL/6J and Fmo5 -/- (FMO5 KO) mice back-crossed onto the C57BL/6J background. The aim of this study was to identify metabolic signatures that are associated with ageing in both these mouse lines and to characterize the age-related differences in the metabolite profiles between the FMO5 KO mice and their wild-type counterparts at equivalent time points...
2018: Frontiers in Molecular Biosciences
https://www.readbyqxmd.com/read/29682508/a-three-ring-circus-metabolism-of-the-three-proteogenic-aromatic-amino-acids-and-their-role-in-the-health-of-plants-and-animals
#15
REVIEW
Anutthaman Parthasarathy, Penelope J Cross, Renwick C J Dobson, Lily E Adams, Michael A Savka, André O Hudson
Tyrosine, phenylalanine and tryptophan are the three aromatic amino acids (AAA) involved in protein synthesis. These amino acids and their metabolism are linked to the synthesis of a variety of secondary metabolites, a subset of which are involved in numerous anabolic pathways responsible for the synthesis of pigment compounds, plant hormones and biological polymers, to name a few. In addition, these metabolites derived from the AAA pathways mediate the transmission of nervous signals, quench reactive oxygen species in the brain, and are involved in the vast palette of animal coloration among others pathways...
2018: Frontiers in Molecular Biosciences
https://www.readbyqxmd.com/read/29670884/distinct-and-modular-organization-of-protein-interacting-sites-in-long-non-coding-rnas
#16
Saakshi Jalali, Shrey Gandhi, Vinod Scaria
Background: Long non-coding RNAs (lncRNAs), are being reported to be extensively involved in diverse regulatory roles and have exhibited numerous disease associations. LncRNAs modulate their function through interaction with other biomolecules in the cell including DNA, RNA, and proteins. The availability of genome-scale experimental datasets of RNA binding proteins (RBP) motivated us to understand the role of lncRNAs in terms of its interactions with these proteins. In the current report, we demonstrate a comprehensive study of interactions between RBP and lncRNAs at a transcriptome scale through extensive analysis of the crosslinking and immunoprecipitation (CLIP) experimental datasets available for 70 RNA binding proteins...
2018: Frontiers in Molecular Biosciences
https://www.readbyqxmd.com/read/29651420/the-human-replicative-helicase-the-cmg-complex-as-a-target-for-anti-cancer-therapy
#17
REVIEW
Yeon-Soo Seo, Young-Hoon Kang
DNA helicases unwind or rearrange duplex DNA during replication, recombination and repair. Helicases of many pathogenic organisms such as viruses, bacteria, and protozoa have been studied as potential therapeutic targets to treat infectious diseases, and human DNA helicases as potential targets for anti-cancer therapy. DNA replication machineries perform essential tasks duplicating genome in every cell cycle, and one of the important functions of these machineries are played by DNA helicases. Replicative helicases are usually multi-subunit protein complexes, and the minimal complex active as eukaryotic replicative helicase is composed of 11 subunits, requiring a functional assembly of two subcomplexes and one protein...
2018: Frontiers in Molecular Biosciences
https://www.readbyqxmd.com/read/29637074/gaussian-based-smooth-dielectric-function-a-surface-free-approach-for-modeling-macromolecular-binding-in-solvents
#18
Arghya Chakravorty, Zhe Jia, Yunhui Peng, Nayere Tajielyato, Lisi Wang, Emil Alexov
Conventional modeling techniques to model macromolecular solvation and its effect on binding in the framework of Poisson-Boltzmann based implicit solvent models make use of a geometrically defined surface to depict the separation of macromolecular interior (low dielectric constant) from the solvent phase (high dielectric constant). Though this simplification saves time and computational resources without significantly compromising the accuracy of free energy calculations, it bypasses some of the key physio-chemical properties of the solute-solvent interface, e...
2018: Frontiers in Molecular Biosciences
https://www.readbyqxmd.com/read/29616226/xpd-the-lynchpin-of-ner-molecule-gene-polymorphisms-and-role-in-colorectal-carcinogenesis
#19
REVIEW
Aga Syed Sameer, Saniya Nissar
In mammals the bulky DNA adduct lesions known to result in deleterious phenotypes are acted upon and removed from the genomic DNA by nucleotide excision repair (NER) pathway. TFIIH multi-protein complex with its important helicase-Xeroderma Pigmentosum Protein (XPD) serves as the pivotal factor for opening up of the damaged lesion DNA site and carry out the repair process. The initial damage verification step of the TFIIH is in part dependent upon the helicase activity of XPD. Besides, XPD is also actively involved in the initiation steps of transcription and in the regulation of the cell cycle and apoptosis...
2018: Frontiers in Molecular Biosciences
https://www.readbyqxmd.com/read/29616225/toxicological-effects-of-berberine-and-sanguinarine
#20
REVIEW
Nitika Singh, Bechan Sharma
Berberine and Sanguinarine alkaloids belong to a group of naturally occurring chemical compounds that mostly contain basic nitrogen atoms. This group also includes some related compounds with neutral or weakly acidic properties. Alkaloids are produced by a large number of organisms including bacteria, fungi, plants, and animals. Berberine and Sanguinarine both are isoquinoline derivatives and belong to protoberberine and benzophenanthridines, respectively. Tyrosine or phenylalanine is common precursor for the biosynthesis of both...
2018: Frontiers in Molecular Biosciences
journal
journal
50073
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"