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JAMA Oncology

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https://www.readbyqxmd.com/read/28796873/new-painful-nodules-in-a-patient-with-multiple-myeloma
#1
Edison W Tsui, Eunjung Choi, Kenneth R Meehan
No abstract text is available yet for this article.
August 10, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/28796865/telomere-length-and-risk-of-cancer-and-non-neoplastic-diseases-is-survivin-the-ariadne-s-thread-reply
#2
Philip C Haycock, Gibran Hemani, Abraham Aviv
No abstract text is available yet for this article.
August 10, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/28796864/individualized-adaptive-stereotactic-body-radiotherapy-for-liver-tumors-in-patients-at-high-risk-for-liver-damage-a-phase-2-clinical-trial
#3
Mary Feng, Krithika Suresh, Matthew J Schipper, Latifa Bazzi, Edgar Ben-Josef, Martha M Matuszak, Neehar D Parikh, Theodore H Welling, Daniel Normolle, Randall K Ten Haken, Theodore S Lawrence
Importance: Patients with preexisting liver dysfunction could benefit the most from personalized therapy for liver tumors to balance maximal tumor control and minimal risk of liver failure. We designed an individualized adaptive trial testing the hypothesis that adapting treatment based on change in liver function could optimize the therapeutic index for each patient. Objective: To characterize the safety and efficacy of individualized adaptive stereotactic body radiotherapy (SRBT) for liver tumors in patients who have preexisting liver dysfunction...
August 10, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/28796863/telomere-length-and-risk-of-cancer-and-non-neoplastic-diseases-is-survivin-the-ariadne-s-thread
#4
Raffaella Mormile
No abstract text is available yet for this article.
August 10, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/28796862/out-of-pocket-costs-financial-distress-and-underinsurance-in-cancer-care
#5
Fumiko Chino, Jeffrey M Peppercorn, Christel Rushing, Arif H Kamal, Ivy Altomare, Greg Samsa, S Yousuf Zafar
No abstract text is available yet for this article.
August 10, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/28796857/association-of-systemic-inflammation-and-sarcopenia-with-survival-in-nonmetastatic-colorectal-cancer-results-from-the-c-scans-study
#6
Elizabeth M Cespedes Feliciano, Candyce H Kroenke, Jeffrey A Meyerhardt, Carla M Prado, Patrick T Bradshaw, Marilyn L Kwan, Jingjie Xiao, Stacey Alexeeff, Douglas Corley, Erin Weltzien, Adrienne L Castillo, Bette J Caan
Importance: Systemic inflammation and sarcopenia are easily evaluated, predict mortality in many cancers, and are potentially modifiable. The combination of inflammation and sarcopenia may be able to identify patients with early-stage colorectal cancer (CRC) with poor prognosis. Objective: To examine associations of prediagnostic systemic inflammation with at-diagnosis sarcopenia, and determine whether these factors interact to predict CRC survival, adjusting for age, ethnicity, sex, body mass index, stage, and cancer site...
August 10, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/28772307/cancer-screening-in-li-fraumeni-syndrome
#7
Peter H Asdahl, Rohit P Ojha, Henrik Hasle
No abstract text is available yet for this article.
August 3, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/28772306/lung-adenocarcinoma-as-part-of-the-li-fraumeni-syndrome-spectrum-preliminary-data-of-the-lifscreen-randomized-clinical-trial
#8
Olivier Caron, Thierry Frebourg, Patrick R Benusiglio, Stéphanie Foulon, Laurence Brugières
No abstract text is available yet for this article.
August 3, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/28772302/cancer-risk-in-families-fulfilling-the-amsterdam-criteria-for-lynch-syndrome
#9
N Jewel Samadder, Ken Robert Smith, Jathine Wong, Alun Thomas, Heidi Hanson, Kenneth Boucher, Cathryn Kopituch, Lisa A Cannon-Albright, Randall W Burt, Karen Curtin
Importance: The data describing cancer risks associated with Lynch syndrome are variable. Objectives: To quantify the prevalence of families that fulfill the Amsterdam I or II criteria for Lynch syndrome in the Utah population and investigate the risk of colonic and extracolonic cancers in family members and their relatives. Design, Setting, and Participants: In a population-based study, 202 families with Amsterdam I and II criteria-positive pedigrees in the Utah Population Database were identified...
August 3, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/28772294/surveillance-of-dutch-patients-with-li-fraumeni-syndrome-the-life-guard-study
#10
Marielle W G Ruijs, Claudette E Loo, Colette A J M van Buchem, Eveline M A Bleiker, Gabe S Sonke
No abstract text is available yet for this article.
August 3, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/28772291/baseline-surveillance-in-li-fraumeni-syndrome-using-whole-body-magnetic-resonance-imaging-a-meta-analysis
#11
Mandy L Ballinger, Ana Best, Phuong L Mai, Payal P Khincha, Jennifer T Loud, June A Peters, Maria Isabel Achatz, Rubens Chojniak, Alexandre Balieiro da Costa, Karina Miranda Santiago, Judy Garber, Allison F O'Neill, Rosalind A Eeles, D Gareth Evans, Eveline Bleiker, Gabe S Sonke, Marielle Ruijs, Claudette Loo, Joshua Schiffman, Anne Naumer, Wendy Kohlmann, Louise C Strong, Jasmina Bojadzieva, David Malkin, Surya P Rednam, Elena M Stoffel, Erika Koeppe, Jeffrey N Weitzel, Thomas P Slavin, Bita Nehoray, Mark Robson, Michael Walsh, Lorenzo Manelli, Anita Villani, David M Thomas, Sharon A Savage
Importance: Guidelines for clinical management in Li-Fraumeni syndrome, a multiple-organ cancer predisposition condition, are limited. Whole-body magnetic resonance imaging (WBMRI) may play a role in surveillance of this high-risk population. Objective: To assess the clinical utility of WBMRI in germline TP53 mutation carriers at baseline. Data Sources: Clinical and research surveillance cohorts were identified through the Li-Fraumeni Exploration Research Consortium...
August 3, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/28772290/surveillance-in-germline-tp53-mutation-carriers-utilizing-whole-body-magnetic-resonance-imaging
#12
Mandy L Ballinger, Nicholas J Ferris, Kate Moodie, Gillian Mitchell, Sue Shanley, Paul A James, David M Thomas
No abstract text is available yet for this article.
August 3, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/28772289/association-of-mismatch-repair-mutation-with-age-at-cancer-onset-in-lynch-syndrome-implications-for-stratified-surveillance-strategies
#13
Neil A J Ryan, Julie Morris, Kate Green, Fiona Lalloo, Emma R Woodward, James Hill, Emma J Crosbie, D Gareth Evans
Importance: Lynch syndrome is caused by dominantly inherited germline mutations that predispose individuals to colorectal, endometrial, ovarian, and other cancers through inactivation of the cellular mismatch repair system. Lynch syndrome-associated cancers are amenable to surveillance strategies that may improve survival. The age at which surveillance should start is disputed. Objective: To determine whether mutated gene and type of mutation influence age at onset of Lynch syndrome-associated cancers...
August 3, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/28772286/prevalence-of-cancer-at-baseline-screening-in-the-national-cancer-institute-li-fraumeni-syndrome-cohort
#14
Phuong L Mai, Payal P Khincha, Jennifer T Loud, Rosamma M DeCastro, Renée C Bremer, June A Peters, Chia-Ying Liu, David A Bluemke, Ashkan A Malayeri, Sharon A Savage
Importance: Establishment of an optimal cancer surveillance program is important to reduce cancer-related morbidity and mortality in individuals with Li-Fraumeni syndrome, a rare, highly penetrant cancer predisposition syndrome. Objective: To determine the feasibility and efficacy of a comprehensive cancer screening regimen in Li-Fraumeni syndrome, using multiple radiologic techniques, including rapid whole-body magnetic resonance imaging (MRI) and laboratory measurements...
August 3, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/28750133/role-of-cytotoxic-tumor-infiltrating-lymphocytes-in-predicting-outcomes-in-metastatic-her2-positive-breast-cancer-a-secondary-analysis-of-a-randomized-clinical-trial
#15
Shuzhen Liu, Bingshu Chen, Samantha Burugu, Samuel Leung, Dongxia Gao, Shakeel Virk, Zuzana Kos, Wendy R Parulekar, Lois Shepherd, Karen A Gelmon, Torsten O Nielsen
Importance: Accumulating evidence indicates that tumor-infiltrating lymphocytes (TILs) are associated with clinical outcomes and may predict the efficacy of chemotherapy and human epidermal growth factor receptor 2 (HER2, encoded by the gene ERBB2)-targeted therapy in patients with HER2-positive breast cancer. Objective: To investigate the role of TILs, particularly cytotoxic CD8+ T cells, in the prediction of outcomes in patients with HER2-positive metastatic breast cancer randomized to an antibody-based (trastuzumab) vs a small molecule-based (lapatinib) anti-HER2 therapy...
July 27, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/28750129/pemetrexed-in-nonsquamous-non-small-cell-lung-cancer-the-billion-dollar-subgroup-analysis
#16
Bishal Gyawali, Vinay Prasad
No abstract text is available yet for this article.
July 27, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/28750125/demonstrating-noninferiority-of-accelerated-radiotherapy-with-panitumumab-vs-standard-radiotherapy-with-cisplatin-in-locoregionally-advanced-squamous-cell-head-and-neck-carcinoma
#17
https://www.readbyqxmd.com/read/28750120/association-between-genomic-metrics-and-immune-infiltration-in-triple-negative-breast-cancer
#18
Thomas Karn, Tingting Jiang, Christos Hatzis, Nicole Sänger, Ahmed El-Balat, Achim Rody, Uwe Holtrich, Sven Becker, Giampaolo Bianchini, Lajos Pusztai
Importance: Why some triple-negative breast cancers (TNBCs) have high and others have low immune cell infiltration is unknown. Understanding how immune surveillance shapes the cancer genome could help in the selection of patients and the development of more effective immunotherapy strategies. Objective: To examine the association between genomic metrics and the extent of immune infiltration in TNBCs. Design, Setting, and Participants: This study, performed from June 1, 2015, through January 31, 2017, used DNA and RNA sequencing data and messenger RNA expression results from The Cancer Genome Atlas (TCGA) breast cancer data set (n = 1215) to calculate previously described immune metagene expression values and histologic lymphocyte counts to quantify immune infiltration and assign prognostic categories to TNBCs...
July 27, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/28750119/minimal-residual-disease-in-chronic-lymphocytic-leukemia-in-the-era-of-novel-agents-a-review
#19
Meghan Thompson, Danielle Brander, Chadi Nabhan, Anthony Mato
Importance: The landscape of chronic lymphocytic leukemia (CLL) treatment has changed considerably since the first reported assessment of minimal residual disease (MRD) by flow cytometry in 1992. Chemoimmunotherapy (CIT) combinations have become the standard of care for most patients, and novel targeted agents are rapidly being incorporated into the front-line and relapsed settings. Minimal residual disease status has been shown to be a predictor of both progression-free survival (PFS) and overall survival (OS) at the time of response assessment following CIT, but less is known about the relationship between MRD and outcomes after novel oral therapeutics...
July 27, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/28750114/demonstrating-noninferiority-of-accelerated-radiotherapy-with-panitumumab-vs-standard-radiotherapy-with-cisplatin-in-locoregionally-advanced-squamous-cell-head-and-neck-carcinoma-reply
#20
Bingshu E Chen, Lillian L Siu, Wendy R Parulekar
No abstract text is available yet for this article.
July 27, 2017: JAMA Oncology
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