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JAMA Oncology

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https://www.readbyqxmd.com/read/28617920/milestone-analyses-of-immune-checkpoint-inhibitors-targeted-therapy-and-conventional-therapy-in-metastatic-non-small-cell-lung-cancer-trials-a-meta-analysis
#1
Gideon M Blumenthal, Lijun Zhang, Hui Zhang, Dickran Kazandjian, Sean Khozin, Shenghui Tang, Kirsten Goldberg, Rajeshwari Sridhara, Patricia Keegan, Richard Pazdur
Importance: Novel intermediate end points may be useful to detect signals of early activity and prioritize new therapies to treat patients with advanced malignant neoplasms, including metastatic non-small cell lung cancer (mNSCLC). Objective: To explore milestone rate, a proposed intermediate end point for immunotherapy trials. Data Sources: Trials submitted to the US Food and Drug Administration with more than 150 patients and in which the intention-to-treat population was assessed were identified...
June 15, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/28617917/genomic-profiling-of-small-bowel-adenocarcinoma
#2
Alexa B Schrock, Craig E Devoe, Robert McWilliams, James Sun, Thomas Aparicio, Philip J Stephens, Jeffrey S Ross, Richard Wilson, Vincent A Miller, Siraj M Ali, Michael J Overman
Importance: Small-bowel adenocarcinomas (SBAs) are rare cancers with a significantly lower incidence, later stage at diagnosis, and worse overall survival than other intestinal-derived cancers. To date, comprehensive genomic analysis of SBA is lacking. Objective: To perform in-depth genomic characterization of a large series of SBAs and other gastrointestinal tumors to draw comparisons and identify potentially clinically actionable alterations. Design, Setting, and Participants: Prospective analysis was performed of clinical samples from patients with SBA (n = 317), colorectal cancer (n = 6353), and gastric carcinoma (n = 889) collected between August 24, 2012, and February 3, 2016, using hybrid-capture-based genomic profiling, at the request of the individual treating physicians in the course of clinical care for the purpose of making therapy decisions...
June 15, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/28617916/when-somatic-mutations-are-associated-with-a-higher-aggressive-behavior-reply
#3
Rengyun Liu, Mingzhao Xing
No abstract text is available yet for this article.
June 15, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/28617912/mutation-in-braf-v600e-reply
#4
Frank A Sinicrope, Qian Shi, Steven R Alberts
No abstract text is available yet for this article.
June 15, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/28617910/error-in-author-degree
#5
(no author information available yet)
No abstract text is available yet for this article.
June 15, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/28617902/mother-tongue
#6
Charu Agrawal, Daniel Epner
No abstract text is available yet for this article.
June 15, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/28617899/when-somatic-mutations-are-associated-with-a-higher-aggressive-behavior-a-story-of-announced-evidence
#7
Esther Diana Rossi, Maurizio Martini, Luigi Maria Larocca
No abstract text is available yet for this article.
June 15, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/28617898/mutation-in-braf-v600e-a-poor-prognostic-marker-in-stage-iii-colon-cancers-with-deficient-mmr
#8
Sheik Emambux, Guillaume Mouillet, David Tougeron
No abstract text is available yet for this article.
June 15, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/28594987/vitamin-d-and-breast-cancer-survival-the-good-and-the-bad
#9
Raffaella Mormile
No abstract text is available yet for this article.
June 8, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/28594984/prognostic-and-predictive-ability-of-tumor-sidedness-another-vexing-difference-between-localized-and-advanced-colon-cancer
#10
George J Chang, Mithat Gonen
No abstract text is available yet for this article.
June 8, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/28594975/missing-source-credit-for-figure-and-table
#11
(no author information available yet)
No abstract text is available yet for this article.
June 8, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/28594974/association-between-prognosis-and-tumor-laterality-in-early-stage-colon-cancer
#12
Safiya Karim, Kelly Brennan, Sulaiman Nanji, Scott R Berry, Christopher M Booth
Importance: Recent data have suggested that disease biology and outcome of colon cancer may differ between right-sided and left-sided tumors. However, the literature on the prognostic value of tumor laterality is conflicting. Objective: To explore differences in laterality based on disease characteristics and outcomes in a population-based cohort of early-stage colon cancer. Design, Setting, and Participants: This investigation was a population-based retrospective cohort study of patients with early-stage colon cancer from the province of Ontario, Canada...
June 8, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/28594965/vitamin-d-and-breast-cancer-survival-the-good-and-the-bad
#13
Alain Braillon
No abstract text is available yet for this article.
June 8, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/28594964/vitamin-d-and-breast-cancer-survival-in-reply
#14
Song Yao, Christine B Ambrosone, Lawrence H Kushi
No abstract text is available yet for this article.
June 8, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/28594963/biosimilars-curb-your-enthusiasm
#15
Y Tony Yang, Brian Chen, Charles L Bennett
No abstract text is available yet for this article.
June 8, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/28586789/the-effect-of-positive-swog-treatment-trials-on-survival-of-patients-with-cancer-in-the-us-population
#16
Joseph M Unger, Michael LeBlanc, Charles D Blanke
Importance: Recently, tremendous prominence has been given to the investigation of the effect of different research processes as part of the Cancer Moonshot. More than half a century ago, the National Cancer Institute (NCI) established a network of publicly funded cancer cooperative research groups to systematically evaluate new treatments for efficacy and safety. Objective: To examine the extent to which positive NCI-sponsored cancer treatment trials have benefited patients with cancer in the US population...
June 5, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/28586788/trends-in-reoperation-after-initial-lumpectomy-for-breast-cancer-addressing-overtreatment-in-surgical-management
#17
Monica Morrow, Paul Abrahamse, Timothy P Hofer, Kevin C Ward, Ann S Hamilton, Allison W Kurian, Steven J Katz, Reshma Jagsi
Importance: Surgery after initial lumpectomy to obtain more widely clear margins is common and may lead to mastectomy. Objective: To describe surgeons' approach to surgical margins for invasive breast cancer, and changes in postlumpectomy surgery rates, and final surgical treatment following a 2014 consensus statement endorsing a margin of "no ink on tumor." Design, Setting, and Participants: This was a population-based cohort survey study of 7303 eligible women ages 20 to 79 years with stage I and II breast cancer diagnosed in 2013 to 2015 and identified from the Georgia and Los Angeles County, California, Surveillance, Epidemiology, and End Results registries...
June 5, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/28570742/effect-of-midtreatment-pet-ct-adapted-radiation-therapy-with-concurrent-chemotherapy-in-patients-with-locally-advanced-non-small-cell-lung-cancer-a-phase-2-clinical-trial
#18
Feng-Ming Kong, Randall K Ten Haken, Matthew Schipper, Kirk A Frey, James Hayman, Milton Gross, Nithya Ramnath, Khaled A Hassan, Martha Matuszak, Timothy Ritter, Nan Bi, Weili Wang, Mark Orringer, Kemp B Cease, Theodore S Lawrence, Gregory P Kalemkerian
Importance: Our previous studies demonstrated that tumors significantly decrease in size and metabolic activity after delivery of 45 Gy of fractionated radiatiotherapy (RT), and that metabolic shrinkage is greater than anatomic shrinkage. This study aimed to determine whether 18F-fludeoxyglucose-positron emission tomography/computed tomography (FDG-PET/CT) acquired during the course of treatment provides an opportunity to deliver higher-dose radiation to the more aggressive areas of the tumor to improve local tumor control without increasing RT-induced lung toxicity (RILT), and possibly improve survival...
June 1, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/28570734/deconstructing-clinical-trials-help-from-oncology-value-frameworks
#19
Joseph C Del Paggio
No abstract text is available yet for this article.
June 1, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/28570732/interventions-to-improve-oral-chemotherapy-safety-and-quality-a-systematic-review
#20
Jessica A Zerillo, Benjamin A Goldenberg, Ritesh R Kotecha, Alok K Tewari, Joseph O Jacobson, Monika K Krzyzanowska
Importance: With the growing use of oral chemotherapy, there is an urgent need to develop safe and effective systems to administer and manage these agents. A comprehensive synthesis of literature on oral chemotherapy care delivery programs to which clinicians can look for best practices is lacking. Objective: To summarize the peer-reviewed and gray literature on interventions to improve oral chemotherapy care delivery toward describing best practices and identifying current gaps...
June 1, 2017: JAMA Oncology
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