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Archives of Endocrinology and Metabolism

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https://www.readbyqxmd.com/read/29412392/coexistence-of-diffuse-large-b-cell-lymphoma-and-papillary-thyroid-carcinoma-in-a-patient-affected-by-hashimoto-s-thyroiditis
#1
Maria Trovato, Giuseppe Giuffrida, Antonino Seminara, Simone Fogliani, Vittorio Cavallari, Rosaria Maddalena Ruggeri, Alfredo Campennì
Papillary thyroid carcinoma (PTC) is the most common type of thyroid cancer. On the contrary, primary thyroid lymphoma (PTL) is a rare disease, accounting for 2% to 5% of all thyroid malignancies. Despite several cases in which both PTC and PTL arise in the setting of Hashimoto's thyroiditis (HT), the coexistence of both tumors in HT patients is very rare. Herein we report the case of a 66-year-old woman with long-standing nodular HT under replacement therapy, who presented with a fast, painless enlargement in the right anterior side of the neck...
December 2017: Archives of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29412391/more-than-kin-less-than-kind-one-family-and-the-many-faces-of-diabetes-in-youth
#2
Luciana F Franco, Renata Peixoto-Barbosa, Renata P Dotto, José Gilberto H Vieira, Magnus R Dias-da-Silva, Luiz Carlos F Reis, Fernando M A Giuffrida, Andre F Reis
Identification of the correct etiology of diabetes brings important implications for clinical management. In this report, we describe a case of a 4-year old asymptomatic girl with diabetes since age 2, along with several individuals in her family with different etiologies for hyperglycemia identified in youth. Genetic analyses were made by Sanger sequencing, laboratory measurements included HbA1c, lipid profile, fasting C-peptide, pancreatic auto-antibodies (glutamic acid decarboxylase [GAD], Islet Antigen 2 [IA-2], and anti-insulin)...
December 2017: Archives of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29412390/growth-hormone-deficiency-with-advanced-bone-age-phenotypic-interaction-between-ghrh-receptor-and-cyp21a2-mutations-diagnosed-by-sanger-and-whole-exome-sequencing
#3
Fernanda A Correa, Marcela M França, Qing Fang, Qianyi Ma, Tania A Bachega, Andresa Rodrigues, Bilge A Ozel, Jun Z Li, Berenice B Mendonca, Alexander A L Jorge, Luciani R Carvalho, Sally A Camper, Ivo J P Arnhold
Isolated growth hormone deficiency (IGHD) is the most common pituitary hormone deficiency and, clinically, patients have delayed bone age. High sequence similarity between CYP21A2 gene and CYP21A1P pseudogene poses difficulties for exome sequencing interpretation. A 7.5 year-old boy born to second-degree cousins presented with severe short stature (height SDS -3.7) and bone age of 6 years. Clonidine and combined pituitary stimulation tests revealed GH deficiency. Pituitary MRI was normal. The patient was successfully treated with rGH...
December 2017: Archives of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29412389/high-prevalence-of-insulin-resistance-among-brazilian-chronic-hepatitis-c-patients
#4
Livia Melo Villar, Gabriela Cardoso Caldas, Leticia de Paula Scalioni, Juliana Custódio Miguel, Elisangela Ferreira da Silva, Vanessa Alves Marques, Cristiane Alves Villela-Nogueira, Lia Laura Lewis-Ximenez, Elisabeth Lampe
OBJECTIVE: This study aims to estimate the prevalence of insulin resistance (IR) among chronic hepatitis C (CHC) patients and their related laboratory and demographic data. SUBJECTS AND METHODS: In this study, non-diabetic CHC patients referred to Viral Hepatitis Ambulatories from Rio de Janeiro (Brazil) donated blood samples. Insulin was measured using a chemiluminescence immunoassay. IR was determined by HOMA-IR, where HOMA-IR > 2 was defined as IR. RESULTS: A total of 214 CHC patients were recruited (123 females aged 53...
December 2017: Archives of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29412388/effect-of-biliopancreatic-diversion-on-sleep-quality-and-daytime-sleepiness-in-patients-with-obesity-and-type-2-diabetes
#5
Mayra Mello, Ana Carolina J Vasques, José C Pareja, Maria da S de Oliveira, Fernanda S Novaes, Élinton A Chaim, Bruno Geloneze
OBJECTIVE: The poor quality of sleep and the deprivation thereof have been associated with disruption of metabolic homeostasis, favoring the development of obesity and type 2 diabetes (T2DM). We aimed to evaluate the influence of biliopancreatic diversion (BPD) surgery on sleep quality and excessive daytime sleepiness of obese patients with T2DM, comparing them with two control groups consisting of obese and normal weight individuals, both normal glucose tolerant. SUBJECTS AND METHODS: Forty-two women were divided into three groups: LeanControl (n = 11), ObeseControl (n = 13), and ObeseT2DM (n = 18)...
December 2017: Archives of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29412387/relationships-between-adiponectin-levels-the-metabolic-syndrome-and-type-2-diabetes-a-literature-review
#6
Anize Delfino von Frankenberg, André F Reis, Fernando Gerchman
Elevated hepatic glucose production, impaired insulin secretion, and insulin resistance - abnormalities of glucose metabolism typically found in subjects with obesity - are major factors underlying the pathogenesis of type 2 diabetes (DM2) and the metabolic syndrome (MS). Adiponectin is a major regulator of glucose and lipid homeostasis via its insulin-sensitizing properties, and lower levels seems to be associated with the development of DM2 and MS. The purpose of this review is to clarify the mechanisms whereby adiponectin relates to the development of DM2 and MS and the association between polymorphisms of the adiponectin gene, circulating levels of the hormone, and its relationships with DM2...
December 2017: Archives of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29412386/laparoscopic-sleeve-gastrectomy-in-severely-obese-adolescents-effects-on-metabolic-profile
#7
Ruth Rocha Franco, Marina Ybarra, Louise Cominato, Larissa Mattar, Leandra Steinmetz, Durval Damiani, Manoel Carlos Prieto Velhote
OBJECTIVE: The objective was to conduct clinical and metabolic evaluations of obese adolescents before and after laparoscopic sleeve gastrectomy (LSG) (up to 24 months). SUBJECTS AND METHODS: This was designed as a retrospective, descriptive series of cases study, conducted in Instituto da Criança, São Paulo, Brazil. Analysis of clinical and laboratory data from 22 obese adolescents between 14 and 19 years old submitted to LSG between 2007 and 2014. Patients had BMI > 40 kg/m2 or BMI > 35 kg/m2 with comorbidities...
December 2017: Archives of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29412385/serum-selenium-and-selenoprotein-p-levels-in-autoimmune-thyroid-diseases-patients-in-a-select-center-a-transversal-study
#8
Marco Aurélio Ferreira Federige, João Hamilton Romaldini, Ana Beatriz Pinotti Pedro Miklos, Marcia Kiyomi Koike, Kioko Takei, Evandro de Souza Portes
OBJECTIVE: Selenium (Se) supplementation has been used to help prevent the progression of Graves' ophthalmopathy (GO) and autoimmune thyroid diseases (AITD) patients. We investigated Se serum and selenoprotein P (SePP) levels in Graves' disease (GD) with and without GO, Hashimoto's thyroiditis (HT) patients and in 27 control individuals (C). SUBJECTS AND METHODS: We studied 54 female and 19 male patients: 19 with GD without GO, 21 GD with GO, 14 with HT and 19 with HT+LT4...
December 2017: Archives of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29412384/thyroglobulin-levels-before-radioactive-iodine-therapy-and-dynamic-risk-stratification-after-1-year-in-patients-with-differentiated-thyroid-cancer
#9
Leonardo Bandeira, Rosália do Prado Padovani, Ana Luiza Ticly, Adriano Namo Cury, Nilza Maria Scalissi, Marília Martins Silveira Marone, Carolina Ferraz
OBJECTIVES: We sought to assess the relationship between stimulated thyroglobulin (sTg) before radioactive iodine therapy (RIT), and the dynamic risk stratification 1 year after treatment, and to establish the utility of the sTg as a predictor of response to therapy in these patients. A retrospective chart review of patients with differentiated thyroid cancer (DTC) who underwent RIT after surgery and were followed for at least 1 year, was carried out. SUBJECTS AND METHODS: Patients were classified according to the dynamic risk stratification 1 year after initial treatment...
December 2017: Archives of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29412383/metastatic-lymph-node-characteristics-as-predictors-of-recurrence-persistence-in-the-neck-and-distant-metastases-in-differentiated-thyroid-cancer
#10
Mayara Peres Barbosa, Denise Momesso, Daniel Alves Bulzico, Terence Farias, Fernando Dias, Roberto Araújo Lima, Rossana Corbo, Mario Vaisman, Fernanda Vaisman
OBJECTIVE: The aim of this study was to evaluate the association between this characteristic and outcomes in patients with lymph node metastasis in a Brazilian cohort. SUBJECTS AND METHODS: This study examined a retrospective cohort of adult patients diagnosed with differentiated thyroid cancer and lymph node metastases from 1998 to 2015 in two referral centers. Number, location, size and extranodal extension (ENE) of metastatic lymph nodes were assessed and correlated with response to initial therapy...
December 2017: Archives of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29412382/thyroid-disorders-in-obese-patients-does-insulin-resistance-make-a-difference
#11
Nicoleta Răcătăianu, Nicoleta Leach, Cosmina Ioana Bondor, Smaranda Mârza, Daniela Moga, Ana Valea, Cristina Ghervan
OBJECTIVE: The aim of this study was to evaluate the association between insulin resistance and thyroid pathology in obese patients, and compare the results between insulin-resistant and noninsulin-resistant patients. SUBJECTS AND METHODS: Obese/nondiabetic patients, aged 18-70 years, attending the outpatient endocrinology service for 2 years were consecutively included. We evaluated the patients' fasting plasma glucose, insulin, homeostasis model assessment of insulin resistance index (HOMA-IR), thyroid-stimulating hormone (TSH), free thyroxine (FT4), antithyroperoxidase antibodies (TPO-Ab), antithyroglobulin antibodies (Tg-Ab), and thyroid ultrasound...
December 2017: Archives of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29412381/obese-with-higher-fndc5-irisin-levels-have-a-better-metabolic-profile-lower-lipopolysaccharide-levels-and-type-2-diabetes-risk
#12
Ivan Luiz Padilha Bonfante, Mara Patricia Traina Chacon-Mikahil, Diego Trevisan Brunelli, Arthur Fernandes Gáspari, Renata Garbellini Duft, Alexandre Gabarra Oliveira, Tiago Gomes Araujo, Mario Jose Abdalla Saad, Cláudia Regina Cavaglieri
OBJECTIVE: Thus, the aim of this study was to compare if higher or smaller fibronectin type 3 domain-containing protein 5 (FNDC5)/irisin levels are associated with inflammatory and metabolic markers, caloric/macronutrient intake, physical fitness and type 2 diabetes mellitus (T2DM) risk in obese middle-aged men, and also to correlate all variables analyzed with FNDC5/irisin. SUBJECTS AND METHODS: On the basis of a cluster study, middle-aged obese men (IMC: 31.01 ± 1...
December 2017: Archives of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29412380/poor-glycemic-control-can-lead-to-an-early-appearance-of-atherosclerosis-in-patients-with-type-1-diabetes-can-this-be-avoided-by-effective-educational-programs
#13
EDITORIAL
Melanie Rodacki
No abstract text is available yet for this article.
December 2017: Archives of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29412379/muscle-inflammation-and-metabolic-health-is-irisin-the-missing-link
#14
EDITORIAL
Rogério Friedman
No abstract text is available yet for this article.
December 2017: Archives of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29166454/the-clinical-genetics-of-phaeochromocytoma-and-paraganglioma
#15
REVIEW
P T Kavinga Gunawardane, Ashley Grossman
Phaeochromocytoma and paraganglioma are rare catecholamine-producing tumours, recognised to have one of the richest hereditary backgrounds of all neoplasms, with germline mutations seen in approximately 30% of patients. They can be a part of genetic syndromes such as MEN 2 or Neurofibromatosis type 1, or can be found as apparently sporadic tumours. Germline mutations are almost always found in syndromic patients. Nonetheless, apparently sporadic phaeochromocytoma too show high germline mutation rates. Early detection of a genetic mutation can lead to early diagnosis of further tumours via surveillance, early treatment and better prognosis...
October 2017: Archives of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29166453/biochemical-diagnosis-of-acromegaly-without-a-typical-clinical-phenotype-what-are-the-concerns
#16
EDITORIAL
Antonio Ribeiro-Oliveira, Ariel Barkan
No abstract text is available yet for this article.
October 2017: Archives of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29166452/is-the-18f-fdg-pet-ct-the-definite-resource-to-detect-the-recurrence-on-high-risk-thyroid-cancer-patients
#17
EDITORIAL
Carlos Alberto Buchpiguel
No abstract text is available yet for this article.
October 2017: Archives of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28977167/11%C3%AE-hydroxysteroid-dehydrogenase-type-ii-activity-is-affected-by-grapefruit-juice-and-intense-muscular-work
#18
Christopher Kargl, Mohammad Arshad, Fahad Salman, Regina C Schurman, Pedro Del Corral
OBJECTIVE: The enzymatic activity of 11β-hydroxysteroid dehydrogenase-2 (11β-HSD2) is key to protecting mineral corticoid receptors from cortisol and has been implicated in blood pressure regulation. Grapefruit juice (GFJ) and acidity are thought to inhibit this enzyme in vitro. This study examines the effect of GFJ and intense exercise on 11β-HSD2 enzyme activity in vivo. SUBJECTS AND METHODS: Eighteen subjects ingested GFJ or apple juice (CON) on separate days prior to reporting to the laboratory in a randomized order...
September 18, 2017: Archives of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28977161/the-relationship-between-circulating-irisin-retinol-binding-protein-4-adiponectin-and-inflammatory-mediators-in-patients-with-metabolic-syndrome
#19
Omur Tabak, Gonul Simsek, Fusun Erdenen, Volkan Sozer, Tuna Hasoglu, Remise Gelisgen, Esma Altunoglu, Cuneyt Muderrisoglu, Abdulhalim Senyigit, Hafize Uzun
OBJECTIVE: We wanted to investigate whether there is a relationship between circulating irisin, retinol binding protein-4 (RBP-4), adiponectin and proinflammatory mediators implicated in the development of insulin resistance (IR) in metabolic syndrome (MetS). SUBJECTS AND METHODS: In 180 individuals, including controls and patients with MetS, we measured fasting plasma insulin, high sensitivity C-reactive protein (hsCRP), pentraxin-3 (PTX-3), interleukin-33 (IL-33), irisin, RBP-4, and adiponectin using ELISA kits...
September 18, 2017: Archives of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28977159/is-fibroblast-growth-factor-23-a-new-cardiovascular-risk-marker-in-gestational-diabetes
#20
Muhammed Kizilgul, Seyfullah Kan, Selvihan Beysel, Mahmut Apaydin, Ozgur Ozcelik, Mustafa Caliskan, Mustafa Ozbek, Seyda Ozdemir, Erman Cakal
OBJECTIVE: This study was designed to compare the serum levels of fibroblast growth factor 23 (FGF23) among patients with gestational diabetes mellitus (GDM) and healthy pregnant women, and to evaluate the association between hormonal and metabolic parameters. SUBJECTS AND METHODS: A total of 82 pregnant women were consecutively enrolled in the study. Of these, 46 were diagnosed as having GDM; the remaining 36 healthy pregnant women served as controls in a cross-sectional study design...
September 18, 2017: Archives of Endocrinology and Metabolism
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