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Archives of Endocrinology and Metabolism

Yang Lin, Shandong Ye, Yuanyuan He, Sumei Li, Yan Chen, Zhimin Zhai
OBJECTIVE: To observe the effect of short-term insulin intensive treatment on the monocyte chemoattractant protein-1 (MCP-1) as well as on the nuclear factor-kappa B (NF-κB) expression of peripheral blood monocyte. This is also in addition to observing the serum MCP-1 level in newlydiagnosed type 2 diabetic patients and probing its anti-inflammation effects. SUBJECTS AND METHODS: Twenty newly-diagnosed type 2 diabetic patients were treated with an insulin intensive treatment for 2 weeks...
April 5, 2018: Archives of Endocrinology and Metabolism
Fernando A Batista, Marjory A Marcello, Mariana B Martins, Karina C Peres, Ulieme O Cardoso, Aline C D N Silva, Natassia E Bufalo, Fernando A Soares, Márcio J da Silva, Lígia V Assumpção, Laura S Ward
OBJECTIVE: The transcriptional repressor DREAM is involved in thyroid-specific gene expression, thyroid enlargement and nodular development, but its clinical utility is still uncertain. In this study we aimed to investigate whether DREAM mRNA levels differ in different thyroid tumors and how this possible difference would allow the use of DREAM gene expression as molecular marker for diagnostic and/or prognosis purpose. MATERIALS AND METHODS: We quantified DREAM gene mRNA levels and investigated its mutational status, relating its expression and genetic changes to diagnostic and prognostic features of 200 thyroid tumors, being 101 malignant [99 papillary thyroid carcinomas (PTC) and 2 anaplastic thyroid carcinomas] and 99 benign thyroid lesions [49 goiter and 50 follicular adenomas (FA)]...
April 5, 2018: Archives of Endocrinology and Metabolism
Patrícia Künzle Ribeiro Magalhães, Carlos Henrique Miranda, Fernando Crivelenti Vilar, André Schmidt, Roberta Rodrigues Bittar, Giselle Aparecida Caixe de Carvalho Paixão, Edson Zangiacomi Martinez, Léa Maria Zanini Maciel
OBJECTIVE: To evaluate the influence of sample drying and storage temperature on TSH stability in neonatal screening. SUBJECTS AND METHODS: Blood samples from 29 adult volunteers as a surrogate for neonatal blood (10 with normal TSH, 9 with overt hypothyroid and 10 with subclinical hypothyroidism) were spotted on filter paper and dried at 22°C or 35°C for 3 hours. The samples were then stored at 22°C, -4°C, or -20°C, and TSH measurements were performed at day 0 (D0), D7, D30, D60, D180, and D360 of storage...
April 5, 2018: Archives of Endocrinology and Metabolism
Shirlei Kugler Aiçar Súss, Cleo Otaviano Mesa, Gisah Amaral de Carvalho, Fabíola Yukiko Miasaki, Carolina Perez Chaves, Dominique Cochat Fuser, Rossana Corbo, Denise Momesso, Daniel A Bulzico, Hans Graf, Fernanda Vaisman
OBJECTIVE: To retrospectively evaluate the outcomes of patients with low and intermediate risk thyroid carcinoma treated with total thyroidectomy (TT) and who did not undergo radioiodine remnant ablation (RRA) and to compare them to patients receiving low dose of iodine (30 mCi). SUBJECTS AND METHODS: A total of 189 differentiated thyroid cancer (DTC) patients treated with TT followed by 30mCi for RRA or not, followed in two referral centers in Brazil were analyzed...
April 5, 2018: Archives of Endocrinology and Metabolism
Preneet Cheema Brar, Maria Contreras, Xiaozhou Fan, Nipapat Visavachaipan
OBJECTIVE: To study the effect of using a one time high dose "stoss therapy" of vitamin D2 (ergocalciferol: VD2) on indices of insulin sensitivity {whole body sensitivity index: WBISI} and secretion {insulinogenic index: IGI} measured during an oral glucose tolerance test (OGTT) in obese adolescents with VDD (25 OHD; serum metabolite of vit D: < 30 ng/dL). SUBJECTS AND METHODS: In a randomized placebo controlled cross over design 20 obese adolescents with vitamin D deficiency (VDD) had baseline OGTT...
April 5, 2018: Archives of Endocrinology and Metabolism
Carolina Castro Porto Silva Janovsky, Antonio Laurinavicius, Fernando Cesena, Viviane Valente, Carlos Eduardo Ferreira, Cristovão Mangueira, Raquel Conceição, Raul D Santos, Marcio Sommer Bittencourt
OBJECTIVE: We sought to investigate the impact of self-reported fasting duration times on the lipid profile results and its impact on the cardiovascular risk stratification and metabolic syndrome diagnosis. SUBJECTS AND METHODS: We analyzed data from all consecutive individuals evaluated in a comprehensive health examination at the Hospital Israelita Albert Einstein from January to December 2015. We divided these patients in three groups, according to the fasting duration recalled (< 8h, 8-12h and > 12h)...
April 5, 2018: Archives of Endocrinology and Metabolism
Alireza Milajerdi, Zhila Maghbooli, Farzad Mohammadi, Banafsheh Hosseini, Khadijeh Mirzaei
OBJECTIVE: Adipose tissue, particularly visceral adipose tissue, secretes a variety of cytokines, among which progranulin is a glycoprotein related to the immune system. Along with other secreted proteins, progranulin may be associated with bone mineral density. The aim of this study was to find out whether there are associations between the progranulin and bone mineral density among obese people. SUBJECTS AND METHODS: This cross-sectional study was conducted on 244 obese participants (aged 22-52)...
April 5, 2018: Archives of Endocrinology and Metabolism
Abdulzahra Hussain
OBJECTIVE: Metabolic and bariatric surgery has a definite role in the management of obese patients with type 2 diabetes mellitus (T2DM). There is also evidence of such surgery improving the health of type 1 diabetic (T1DM) patients. The aim of this paper is to explore the effect of metabolic and bariatric surgery on T1DM. MATERIALS AND METHODS: A comprehensive search of PubMed and Google Scholar was performed to identify relevant papers reporting metabolic and bariatric surgery effects on T1DM...
April 5, 2018: Archives of Endocrinology and Metabolism
Fabián Pitoia, Fernando Jerkovich, Carolina Urciuoli, Florencia Falcón, Andrea Páes de Lima
OBJECTIVE: To compare the historic risk of recurrence (RR) and response to therapy to risk stratification estimated with historical pathology reports (HPRs) and contemporary re-review of the pathological slides in patients with differentiated thyroid cancer (DTC). SUBJECTS AND METHODS: Out of 210 DTC patients with low and intermediate RR who underwent total thyroidectomy and remnant ablation in our hospital, 63 available historic pathologic samples (HPS) were reviewed...
April 5, 2018: Archives of Endocrinology and Metabolism
Sema Ciftci Dogansen, Gulsah Yenidunya Yalin, Bulent Canbaz, Seher Tanrikulu, Sema Yarman
OBJECTIVE: The aim of this study was to determine the frequency of central thyroid dysfunctions in Cushing's syndrome (CS). We also aimed to evaluate the frequency of hyperthyroidism due to the syndrome of the inappropriate secretion of TSH (SITSH), which was recently defined in patients with insufficient hydrocortisone replacement after surgery. MATERIALS AND METHODS: We evaluated thyroid functions (TSH and free thyroxine [fT4]) at the time of diagnosis, during the hypothalamo-pituitary-adrenal axis recovery, and after surgery in 35 patients with CS...
April 5, 2018: Archives of Endocrinology and Metabolism
Bruno Mussoi de Macedo, Rogério F Izquierdo, Lenara Golbert, Erika L Souza Meyer
OBJECTIVE: Ultrasonography (US) is the best diagnostic tool for initial assessment of thyroid nodule. Recently, data reporting systems for thyroid lesions, such as the Thyroid Imaging Reporting and Data System (TI-RADS) and American Thyroid Association (ATA), which stratifies the risk for malignancy, have demonstrated good performance in differentiating malignant thyroid nodules. The purpose of this study is to determine the reliability of both data reporting systems in predicting thyroid malignancy in a tertiary care hospital...
April 5, 2018: Archives of Endocrinology and Metabolism
Fausto Fama, Alessandro Sindoni, Marco Cicciu, Francesca Polito, Arnaud Piquard, Olivier Saint-Marc, Maria Gioffre-Florio, Salvatore Benvenga
OBJECTIVE: Incidental thyroid cancers (ITCs) are often microcarcinomas; among them, the most frequent histotype is the papillary one. The purpose of this study was to evaluate the rate of papillary thyroid cancer (PTC) in patients thyroidectomized for benign multinodular goiter. SUBJECT AND METHODS: We retrospectively evaluated the histological incidence of PTC in 207 consecutive patients who, in a 1-year period, underwent thyroidectomy for benign multinodular goiter...
April 5, 2018: Archives of Endocrinology and Metabolism
Maria Trovato, Giuseppe Giuffrida, Antonino Seminara, Simone Fogliani, Vittorio Cavallari, Rosaria Maddalena Ruggeri, Alfredo Campennì
Papillary thyroid carcinoma (PTC) is the most common type of thyroid cancer. On the contrary, primary thyroid lymphoma (PTL) is a rare disease, accounting for 2% to 5% of all thyroid malignancies. Despite several cases in which both PTC and PTL arise in the setting of Hashimoto's thyroiditis (HT), the coexistence of both tumors in HT patients is very rare. Herein we report the case of a 66-year-old woman with long-standing nodular HT under replacement therapy, who presented with a fast, painless enlargement in the right anterior side of the neck...
December 2017: Archives of Endocrinology and Metabolism
Luciana F Franco, Renata Peixoto-Barbosa, Renata P Dotto, José Gilberto H Vieira, Magnus R Dias-da-Silva, Luiz Carlos F Reis, Fernando M A Giuffrida, Andre F Reis
Identification of the correct etiology of diabetes brings important implications for clinical management. In this report, we describe a case of a 4-year old asymptomatic girl with diabetes since age 2, along with several individuals in her family with different etiologies for hyperglycemia identified in youth. Genetic analyses were made by Sanger sequencing, laboratory measurements included HbA1c, lipid profile, fasting C-peptide, pancreatic auto-antibodies (glutamic acid decarboxylase [GAD], Islet Antigen 2 [IA-2], and anti-insulin)...
December 2017: Archives of Endocrinology and Metabolism
Fernanda A Correa, Marcela M França, Qing Fang, Qianyi Ma, Tania A Bachega, Andresa Rodrigues, Bilge A Ozel, Jun Z Li, Berenice B Mendonca, Alexander A L Jorge, Luciani R Carvalho, Sally A Camper, Ivo J P Arnhold
Isolated growth hormone deficiency (IGHD) is the most common pituitary hormone deficiency and, clinically, patients have delayed bone age. High sequence similarity between CYP21A2 gene and CYP21A1P pseudogene poses difficulties for exome sequencing interpretation. A 7.5 year-old boy born to second-degree cousins presented with severe short stature (height SDS -3.7) and bone age of 6 years. Clonidine and combined pituitary stimulation tests revealed GH deficiency. Pituitary MRI was normal. The patient was successfully treated with rGH...
December 2017: Archives of Endocrinology and Metabolism
Livia Melo Villar, Gabriela Cardoso Caldas, Leticia de Paula Scalioni, Juliana Custódio Miguel, Elisangela Ferreira da Silva, Vanessa Alves Marques, Cristiane Alves Villela-Nogueira, Lia Laura Lewis-Ximenez, Elisabeth Lampe
OBJECTIVE: This study aims to estimate the prevalence of insulin resistance (IR) among chronic hepatitis C (CHC) patients and their related laboratory and demographic data. SUBJECTS AND METHODS: In this study, non-diabetic CHC patients referred to Viral Hepatitis Ambulatories from Rio de Janeiro (Brazil) donated blood samples. Insulin was measured using a chemiluminescence immunoassay. IR was determined by HOMA-IR, where HOMA-IR > 2 was defined as IR. RESULTS: A total of 214 CHC patients were recruited (123 females aged 53...
December 2017: Archives of Endocrinology and Metabolism
Mayra Mello, Ana Carolina J Vasques, José C Pareja, Maria da S de Oliveira, Fernanda S Novaes, Élinton A Chaim, Bruno Geloneze
OBJECTIVE: The poor quality of sleep and the deprivation thereof have been associated with disruption of metabolic homeostasis, favoring the development of obesity and type 2 diabetes (T2DM). We aimed to evaluate the influence of biliopancreatic diversion (BPD) surgery on sleep quality and excessive daytime sleepiness of obese patients with T2DM, comparing them with two control groups consisting of obese and normal weight individuals, both normal glucose tolerant. SUBJECTS AND METHODS: Forty-two women were divided into three groups: LeanControl (n = 11), ObeseControl (n = 13), and ObeseT2DM (n = 18)...
December 2017: Archives of Endocrinology and Metabolism
Anize Delfino von Frankenberg, André F Reis, Fernando Gerchman
Elevated hepatic glucose production, impaired insulin secretion, and insulin resistance - abnormalities of glucose metabolism typically found in subjects with obesity - are major factors underlying the pathogenesis of type 2 diabetes (DM2) and the metabolic syndrome (MS). Adiponectin is a major regulator of glucose and lipid homeostasis via its insulin-sensitizing properties, and lower levels seems to be associated with the development of DM2 and MS. The purpose of this review is to clarify the mechanisms whereby adiponectin relates to the development of DM2 and MS and the association between polymorphisms of the adiponectin gene, circulating levels of the hormone, and its relationships with DM2...
December 2017: Archives of Endocrinology and Metabolism
Ruth Rocha Franco, Marina Ybarra, Louise Cominato, Larissa Mattar, Leandra Steinmetz, Durval Damiani, Manoel Carlos Prieto Velhote
OBJECTIVE: The objective was to conduct clinical and metabolic evaluations of obese adolescents before and after laparoscopic sleeve gastrectomy (LSG) (up to 24 months). SUBJECTS AND METHODS: This was designed as a retrospective, descriptive series of cases study, conducted in Instituto da Criança, São Paulo, Brazil. Analysis of clinical and laboratory data from 22 obese adolescents between 14 and 19 years old submitted to LSG between 2007 and 2014. Patients had BMI > 40 kg/m2 or BMI > 35 kg/m2 with comorbidities...
December 2017: Archives of Endocrinology and Metabolism
Marco Aurélio Ferreira Federige, João Hamilton Romaldini, Ana Beatriz Pinotti Pedro Miklos, Marcia Kiyomi Koike, Kioko Takei, Evandro de Souza Portes
OBJECTIVE: Selenium (Se) supplementation has been used to help prevent the progression of Graves' ophthalmopathy (GO) and autoimmune thyroid diseases (AITD) patients. We investigated Se serum and selenoprotein P (SePP) levels in Graves' disease (GD) with and without GO, Hashimoto's thyroiditis (HT) patients and in 27 control individuals (C). SUBJECTS AND METHODS: We studied 54 female and 19 male patients: 19 with GD without GO, 21 GD with GO, 14 with HT and 19 with HT+LT4...
December 2017: Archives of Endocrinology and Metabolism
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