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Transplantation Direct

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https://www.readbyqxmd.com/read/27826606/resolution-of-calciphylaxis-after-urgent-kidney-transplantation-in-3-patients-with-end-stage-kidney-failure
#1
Espen Nordheim, Dag Olav Dahle, Ingrid Marie Syse, Anders Åsberg, Anna V Reisæter, Anders Hartmann
BACKGROUND: Calcific uremic arteriolopathy (CUA), also referred to as calciphylaxis, is a rare and serious complication of kidney failure with limited treatment options. Kidney transplantation (KTX) restores kidney function and is hence a potential treatment option for CUA. We present 3 patients who had their CUA lesions successfully healed after urgent KTX. METHODS: Data were retrospectively retrieved from hospital records at our national transplant center. RESULTS: All 3 patients had previously been kidney transplanted and had experienced graft loss and were in stage 5 kidney failure when CUA developed...
November 2016: Transplantation Direct
https://www.readbyqxmd.com/read/27826605/temporal-changes-in-deceased-kidney-donor-characteristics-in-australia
#2
Samuel Chan, Scott B Campbell, Phillip A Clayton, David W Mudge, Yeoungjee Cho, Carmel M Hawley, David W Johnson, Ross S Francis
BACKGROUND: Demand for deceased donor kidneys has exceeded supply in Australia over the past 2 decades. With a desire to use as many donor organs as possible, the health characteristics of accepted donors may have changed over time. METHODS: All deceased kidney donors actually transplanted in Australia between January 1, 1994, and December 31, 2013, were retrospectively analyzed, using data from the Australian and New Zealand Organ Donor Registry. RESULTS: Of 4172 deceased donors, 57% were men...
November 2016: Transplantation Direct
https://www.readbyqxmd.com/read/27826604/virtual-global-transplant-laboratory-standard-operating-protocol-for-donor-alloantigen-specific-interferon-gamma-elispot-assay
#3
Robert Carroll, Alexander Troelnikov, Anita S Chong
The quantification of frequency of IFN-γ-producing T cells responding to donor alloantigen using the IFN-γ enzyme linked immunosorbent spot (ELISPOT) holds potential for pretransplant and posttransplant immunological risk stratification. The effectiveness of this assay, and the ability to compare results generated by different studies, is dependent on the utilization of a standardized operating procedure (SOP). Key factors in assay standardization include the identification of primary and secondary antibody pairs, and the reading of the ELISPOT plate with a standardized automated algorithm...
November 2016: Transplantation Direct
https://www.readbyqxmd.com/read/27826603/liberation-from-renal-replacement-therapy-after-cadaveric-liver-transplantation
#4
Ibtesam A Hilmi, Ali Al-Khafaji, Daniela Damian, Bedda L Rosario-Rivera, Ali Abdullah, John A Kellum
BACKGROUND: Renal failure requiring renal replacement therapy (RRT) is common in patients with end-stage liver disease (ESLD) and is associated with worse outcomes following liver transplantation (LT). We investigated the factors associated with liberation from posttransplant RRT and studied the impact of RRT on patient and graft outcomes. METHODS: A 5-year retrospective study of ESLD patients who received pretransplant RRT was conducted. Variables associated with liberation from RRT at 30 days and at 1-year posttransplant were analyzed...
November 2016: Transplantation Direct
https://www.readbyqxmd.com/read/27826602/a-novel-method-for-anti-hla-antibody-detection-using-personalized-peptide-arrays
#5
Pan Liu, Tomokazu Souma, Andrew Zu-Sern Wei, Xueying Xie, Xunrong Luo, Jing Jin
BACKGROUND: HLA mismatches are the primary cause of alloantibody-mediated rejection (AMR) in organ transplantation. To delineate antigenic and immunogenic potentials among individual HLA mismatches, information regarding antibody specificity at the epitope level, instead of the allelic level, is needed. METHODS: This study explores a direct screening method for HLA linear epitopes in kidney transplant patients. We custom synthesized a large panel of 15-residue HLA peptides in an array format and measured alloantibody reactivity to these peptides from the sera of post and/or pretransplant patients...
November 2016: Transplantation Direct
https://www.readbyqxmd.com/read/27826601/plasma-micrornas-are-potential-biomarkers-of-acute-rejection-after-hindlimb-transplantation-in-rats
#6
Hiroki Oda, Ryosuke Ikeguchi, Hirofumi Yurie, Yukitoshi Kaizawa, Souichi Ohta, Koji Yamamoto, Tomoki Aoyama, Shuichi Matsuda
BACKGROUND: The development of effective immunosuppressive regimens has resulted in many cases of successful hand transplantation. Visual skin inspection and histological evaluation are used to assess the rejection of hand transplants, but these methods are largely subjective. In this study, we aimed to determine the potential of microRNAs (miRNAs) as biomarkers for acute rejection in vascularized composite allotransplants. METHODS: In allograft group, 7 male Brown-Norway rats (RT1(n)) were used as donors and 13 male Lewis rats (RT1(l)) were used as recipients...
November 2016: Transplantation Direct
https://www.readbyqxmd.com/read/27826600/a-prospective-study-of-renal-transplant-recipients-a-fall-in-insulin-secretion-underpins-dysglycemia-after-renal-transplantation
#7
David Langsford, Varuni Obeyesekere, Sara Vogrin, Jessie Teng, Richard J MacIsaac, Glenn Ward, Frank Alford, Karen M Dwyer
BACKGROUND: Dysglycemia (encompassing impaired glucose tolerance and diabetes mellitus) arising after renal transplantation is common and confers a significant cardiovascular mortality risk. Nonetheless, the pathophysiology of posttransplant dysglycemia is not well described. The aim of this study was to prospectively and comprehensively assess glucose handling in renal transplant recipients from before to 12 months after transplantation to determine the underpinning pathophysiology. MATERIALS AND METHODS: Intravenous and oral glucose tolerance testing was conducted before and at 3 and 12 months posttransplantation...
November 2016: Transplantation Direct
https://www.readbyqxmd.com/read/27795988/sex-related-differences-in-the-risk-of-antibody-mediated-rejection-and-subsequent-allograft-vasculopathy-post-heart-transplantation-a-single-center-experience
#8
Avishay Grupper, Emilija M Nestorovic, Richard C Daly, Natasa M Milic, Lyle D Joyce, John M Stulak, David L Joyce, Brooks S Edwards, Naveen L Pereira, Sudhir S Kushwaha
BACKGROUND: Pregnancies may result in antibodies against HLA, a risk factor for antibody-mediated rejection (AMR) and subsequent cardiac allograft vasculopathy (CAV) after heart transplantation (HTx). The aim of this study was to evaluate sex differences in the incidence of AMR events and subsequent risk of CAV among HTx recipients. METHODS: The study comprised 160 patients (51 [32%] women) who underwent HTx in 2008 to 2014. The cumulative effect of AMR events was calculated by AMR score (sum of myocardial biopsy grading divided by number of biopsies taken during 3 years post-HTx)...
October 2016: Transplantation Direct
https://www.readbyqxmd.com/read/27795987/outcomes-of-pancreatic-islet-allotransplantation-using-the-edmonton-protocol-at-the-university-of-chicago
#9
Zehra Tekin, Marc R Garfinkel, W James Chon, Lindsay Schenck, Karolina Golab, Omid Savari, J Richard Thistlethwaite, Louis H Philipson, Colleen Majewski, Silvana Pannain, Sabarinathan Ramachandran, Kourosh Rezania, Seenu M Hariprasad, J Michael Millis, Piotr Witkowski
OBJECTIVE: The aim of this study was to assess short-term and long-term results of the pancreatic islet transplantation using the Edmonton protocol at the University of Chicago. MATERIALS AND METHODS: Nine patients underwent pancreatic islet cell transplantation using the Edmonton Protocol; they were followed up for 10 years after initial islet transplant with up to 3 separate islet infusions. They were given induction treatment using an IL-2R antibody and their maintenance immunosuppression regimen consisted of sirolimus and tacrolimus...
October 2016: Transplantation Direct
https://www.readbyqxmd.com/read/27795986/reluctance-to-accept-alcohol-treatment-by-alcoholic-liver-disease-transplant-patients-a-qualitative-study
#10
Cathy M Heyes, Toni Schofield, Robert Gribble, Carolyn A Day, Paul S Haber
BACKGROUND: Liver transplantation (LT) is the optimum treatment for patients with end-stage alcoholic liver disease (ALD). However, despite a recognized risk of relapse to harmful drinking, ALD transplant patients are reluctant to use speciality alcohol treatment to support their abstinence, even when offered within the LT context. This study aimed to understand and identify factors contributing to alcohol treatment reluctance by ALD patients undergoing transplantation. METHODS: We conducted an in-depth qualitative study of ALD transplant patients...
October 2016: Transplantation Direct
https://www.readbyqxmd.com/read/27795995/low-levels-of-exhaled-surfactant-protein-a-associated-with-bos-after-lung-transplantation
#11
Petrea A Ericson, Ekaterina Mirgorodskaya, Oscar S Hammar, Emilia A Viklund, Ann-Charlotte R Almstrand, Per J-W Larsson, Gerdt C Riise, Anna-Carin Olin
BACKGROUND: There is no clinically available marker for early detection or monitoring of chronic rejection in the form of bronchiolitis obliterans syndrome (BOS), the main long-term complication after lung transplantation. Sampling and analysis of particles in exhaled air is a valid, noninvasive method for monitoring surfactant protein A (SP-A) and albumin in the distal airways. METHODS: We asked whether differences in composition of exhaled particles can be detected when comparing stable lung transplant recipients (LTRs) (n = 26) with LTRs who develop BOS (n = 7)...
September 2016: Transplantation Direct
https://www.readbyqxmd.com/read/27795994/assessment-of-4-cases-of-kidney-transplantation-from-hepatitis-c-virus-antibody-positive-and-rna-negative-donors-to-antibody-negative-recipients
#12
Kohei Unagami, Hideki Ishida, Masayoshi Okumi, Toshihito Hirai, Daisuke Toki, Kazuya Omoto, Tomokazu Shimizu, Masashi Inui, Kosaku Nitta, Kazunari Tanabe
No abstract text is available yet for this article.
September 2016: Transplantation Direct
https://www.readbyqxmd.com/read/27795993/virtual-global-transplant-laboratory-standard-operating-procedures-for-blood-collection-pbmc-isolation-and-storage
#13
Lauren E Higdon, Karim Lee, Qizhi Tang, Jonathan S Maltzman
Research on human immune responses frequently involves the use of peripheral blood mononuclear cells (PBMC) immediately, or at significantly delayed timepoints, after collection. This requires PBMC isolation from whole blood and cryopreservation for some applications. It is important to standardize protocols for blood collection, PBMC isolation, cryopreservation, and thawing that maximize survival and functionality of PBMC at the time of analysis. This resource includes detailed protocols describing blood collection tubes, isolation of PBMC using a density gradient, cryopreservation of PBMC, and thawing of cells as well as preparation for functional assays...
September 2016: Transplantation Direct
https://www.readbyqxmd.com/read/27795992/first-publication-of-standardized-immune-monitoring-methods-from-the-virtual-global-transplantation-laboratory-initiative
#14
Edward K Geissler
No abstract text is available yet for this article.
September 2016: Transplantation Direct
https://www.readbyqxmd.com/read/27795991/donor-characteristics-of-pancreas-transplantation-in-australia-and-new-zealand-a-cohort-study-1984-2014
#15
Xi Alex Peng, Patrick J Kelly, William R Mulley, Henry Pleass, Helen Pilmore, Angela C Webster
BACKGROUND: The aim of this study was to audit the characteristics of pancreas donors over time in Australia and New Zealand. Pancreas transplantation was introduced in Australian and New Zealand in 1984. METHODS: We analyzed data from the Australia and New Zealand Islet and Pancreas Transplant Registry, 1984 to 2014. We investigated the variation of donor characteristics of sex, age, body mass index, smoking status, blood group, multiple organ donation, cytomegalovirus status, terminal creatinine, hypertension, and cause of death for pancreas transplantation over time...
September 2016: Transplantation Direct
https://www.readbyqxmd.com/read/27795990/early-kidney-allograft-dysfunction-threatened-allograft-comparative-effectiveness-of-continuing-versus-discontinuation-of-tacrolimus-and-use-of-sirolimus-to-prevent-graft-failure-a-retrospective-patient-centered-outcome-study
#16
Ravinder K Wali, Heather A Prentice, Venkata Reddivari, Geroge Baffoe-Bonnie, Cinthia I Drachenberg, John C Pappadimitriou, Emilio Ramos, Matthew Cooper, Johann Jonsson, Stephen Bartlett, Matthew R Weir
BACKGROUND: Due to lack of treatment options for early acute allograft dysfunction in the presence of tubular-interstitial injury without histological features of rejection, kidney transplant recipients are often treated with sirolimus-based therapy to prevent cumulative calcineurin inhibitor exposure and to prevent premature graft failure. METHODS: We analyzed transplant recipients treated with sirolimus-based (n = 220) compared with continued tacrolimus-based (n = 276) immunosuppression in recipients of early-onset graft dysfunction (threatened allograft) with the use of propensity score-based inverse probability treatment weighted models to balance for potential confounding by indication between 2 nonrandomized groups...
September 2016: Transplantation Direct
https://www.readbyqxmd.com/read/27795989/normothermic-machine-perfusion-of-deceased-donor-liver-grafts-is-associated-with-improved-postreperfusion-hemodynamics
#17
Roberta Angelico, M Thamara P R Perera, Reena Ravikumar, David Holroyd, Constantin Coussios, Hynek Mergental, John R Isaac, Asim Iqbal, Hentie Cilliers, Paolo Muiesan, Peter J Friend, Darius F Mirza
BACKGROUND: Graft reperfusion poses a critical challenge during liver transplantation and can be associated with hemodynamic instability/postreperfusion syndrome. This is sequel to ischemia-reperfusion injury and normothermic machine preservation (NMP) may affect hemodynamic changes. Herein, we characterize postreperfusion hemodynamics in liver grafts after NMP and traditional cold preservation. MATERIALS AND METHODS: Intraoperative records of patients receiving grafts after NMP (n = 6; NMP group) and cold storage (CS) (n = 12; CS group) were compared...
September 2016: Transplantation Direct
https://www.readbyqxmd.com/read/27819037/classification-of-kidney-transplant-recipients-using-a-combination-of-estimated-gfr-and-albuminuria-reflects-risk
#18
Christine A White, Ayub Akbari, Hari Talreja, Neha Lalani, Greg A Knoll
BACKGROUND: The 2012 Kidney Dialysis Initiative Global Outcomes chronic kidney disease (CKD) classification scheme subdivides stage 3 CKD and incorporates the urinary albumin-to-creatinine ratio (ACR). The aim of this study was to evaluate whether the novel scheme provides graded risk in kidney transplant recipients (KTRs). METHODS: Prevalent KTRs with available laboratory data were included. The primary outcome was a composite of doubling of serum creatinine, graft failure, or death...
August 2016: Transplantation Direct
https://www.readbyqxmd.com/read/27819036/evaluation-of-short-term-ruxolitinib-tapering-strategy-before-allogeneic-stem-cell-transplantation-for-primary-myelofibrosis-through-the-transition-of-serum-cytokines-and-growth-factors
#19
Souichi Shiratori, Takahiro Tateno, Shinichi Ito, Yutaka Tsutsumi, Takanori Teshima
No abstract text is available yet for this article.
August 2016: Transplantation Direct
https://www.readbyqxmd.com/read/27819035/the-kupffer-cell-number-affects-the-outcome-of-living-donor-liver-transplantation-from-elderly-donors
#20
Masaaki Hidaka, Susumu Eguchi, Mitsuhisa Takatsuki, Akihiko Soyama, Shinichiro Ono, Tomohiko Adachi, Koji Natsuda, Tota Kugiyama, Takanobu Hara, Satomi Okada, Hajime Imamura, Satoshi Miuma, Hisamitsu Miyaaki
BACKGROUND: There have been no previous reports how Kupffer cells affect the outcome of living donor liver transplantation (LDLT) with an elderly donor. The aim of this study was to elucidate the influence of Kupffer cells on LDLT. METHODS: A total of 161 adult recipients underwent LDLT. The graft survival, prognostic factors for survival, and graft failure after LDLT were examined between cases with a young donor (<50, n = 112) and an elderly donor (≥50, N = 49)...
August 2016: Transplantation Direct
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