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Transplantation Direct

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https://www.readbyqxmd.com/read/29707630/tacrolimus-induced-hyponatremia-in-lung-transplant-recipients-a-case-series
#1
Paul N Banks, Ashraf Omar, Rajat Walia, Sarabjit Bhalla, Yun Chong, Sofya Tokman
Background: Lung transplant recipients are treated with a 3-drug immunosuppressive regimen that consists of a calcineurin inhibitor, an antiproliferative agent, and a corticosteroid. Calcineurin inhibitors are the backbone of this regimen, and tacrolimus is used more often than cyclosporine, because tacrolimus is the more potent of the two agents. Tacrolimus-induced hyponatremia has been described among kidney transplant recipients, but not among lung transplant recipients. Methods: We conducted a retrospective chart review of patients who underwent lung transplant at our institution and went on to develop severe hyponatremia...
April 2018: Transplantation Direct
https://www.readbyqxmd.com/read/29707629/comparison-of-the-warmcloud-and-bair-hugger-warming-devices-for-the-prevention-of-intraoperative-hypothermia-in-patients-undergoing-orthotopic-liver-transplantation-a-randomized-clinical-trial
#2
Brett Pearce, Linda Mattheyse, Louise Ellard, Fiona Desmond, Param Pillai, Laurence Weinberg
Background: The avoidance of hypothermia is vital during prolonged and open surgery to improve patient outcomes. Hypothermia is particularly common during orthotopic liver transplantation (OLT) and associated with undesirable physiological effects that can adversely impact on perioperative morbidity. The KanMed WarmCloud (Bromma, Sweden) is a revolutionary, closed-loop, warm-air heating mattress developed to maintain normothermia and prevent pressure sores during major surgery. The clinical effectiveness of the WarmCloud device during OLT is unknown...
April 2018: Transplantation Direct
https://www.readbyqxmd.com/read/29707628/poor-patient-and-graft-outcome-after-induction-treatment-by-antithymocyte-globulin-in-recipients-of-a-kidney-graft-after-nonrenal-organ-transplantation
#3
Hoa Le Mai, Michèle Treilhaud, Shani Leviatan Ben-Arye, Hai Yu, Hélène Perreault, Evelyn Ang, Katy Trébern-Launay, Julie Laurent, Stéphanie Malard-Castagnet, Anne Cesbron, Thi Van Ha Nguyen, Sophie Brouard, Lionel Rostaing, Pauline Houssel-Debry, Christophe Legendre, Sophie Girerd, Michèle Kessler, Emmanuel Morelon, Antoine Sicard, Valérie Garrigue, Georges Karam, Xi Chen, Magali Giral, Vered Padler-Karavani, Jean Paul Soulillou
Background: End-stage renal failure occurs in a substantial number of patients having received a nonrenal transplantation (NRT), for whom a kidney transplantation is needed. The medical strategy regarding the use of immunosuppression (IS) for a kidney graft in patients after an NRT is not well established. The prekidney grafts long-term IS advocates for a mild induction, such as using anti-IL-2R antibodies, whereas addition of new incompatibilities and anti-HLA preimmunization may suggest using stronger IS such as induction by polyclonal antithymocyte globulins (ATG)...
April 2018: Transplantation Direct
https://www.readbyqxmd.com/read/29707627/identifying-barriers-to-preemptive-kidney-transplantation-in-a-living-donor-transplant-cohort
#4
Ryan A Helmick, Colleen L Jay, Brittany A Price, Patrick G Dean, Mark D Stegall
Background: Despite substantial evidence demonstrating clear benefit, rates of preemptive kidney transplantation (PreKTx) remain low in the United States. Our goal was to identify barriers to PreKTx. Methods: Using a telephone-administered questionnaire including questions about barriers, timing of referral, timing of education, we retrospectively studied first living donor kidney transplant recipients (2006-2010) at Mayo Clinic, Rochester, MN. Of 235 patients, 145 (62%) responded to the questionnaire (74 PreKTx and 71 non-PreKTx)...
April 2018: Transplantation Direct
https://www.readbyqxmd.com/read/29707626/single-graft-utilization-from-donors-with-severe-acute-kidney-injury-after-circulatory-death
#5
Yusuke Tomita, Kazuhiro Iwadoh, Yuichi Ogawa, Katsuyuki Miki, Kotaro Kai, Akihito Sannomiya, Toru Murakami, Ichiro Koyama, Kumiko Kitajima, Ichiro Nakajima, Shohei Fuchinoue
Chronic shortages of organs for transplantation have led to the use of marginal kidneys from donors after circulatory death with acute kidney injury (AKI), but the utilization of kidneys with severe AKI is not well established. We retrospectively analyzed eight kidney transplantation (KTx) cases from donation after circulatory death (DCD) with terminal creatinine (t-Cr) concentrations higher than 10.0 mg/dL and/or oliguria for more than 5 days (AKI network criteria: stage III). Although all patients showed delayed graft function, no cases of primary nonfunction (PNF) were found...
April 2018: Transplantation Direct
https://www.readbyqxmd.com/read/29707625/composite-mesenchymal-stromal-cell-islets-implications-for-transplantation-via-the-clinically-preferred-intraportal-route
#6
Chloe L Rackham, Paramjeet K Dhadda, Sian J S Simpson, Mahdieh Godazgar, Aileen J F King, Peter M Jones
No abstract text is available yet for this article.
April 2018: Transplantation Direct
https://www.readbyqxmd.com/read/29707624/neurological-sequelae-and-clinical-outcomes-after-lung-transplantation
#7
Patrick J Smith, Gregory L Stonerock, Krista K Ingle, Caroline K Saulino, Benson Hoffman, Brian Wasserman, James A Blumenthal, Scott M Palmer, Jacob A Klapper, Matthew G Hartwig, Valentine R Esposito, Laurie D Snyder
Background: Neurological complications are common after lung transplantation. However, no large cohort studies have examined the incidence, predictors, and clinical significance of neurological events sustained by lung transplant recipients. Methods: We conducted a retrospective cohort analysis of a consecutive series of lung transplant recipients, transplanted at Duke University Medical Center between May 2014 and February 2017 (n = 276). Early neurological complications (ie, occurring during the first week after transplant) were documented by transplant mental health specialists and included delirium, ischemic injury, and posterior reversible encephalopathy syndrome...
April 2018: Transplantation Direct
https://www.readbyqxmd.com/read/29707623/early-allograft-dysfunction-is-associated-with-higher-risk-of-renal-nonrecovery-after-liver-transplantation
#8
Hani M Wadei, David D Lee, Kristopher P Croome, Lorraine Mai, Deanne Leonard, Martin L Mai, C Burcin Taner, Andrew P Keaveny
Early allograft dysfunction (EAD) identifies allografts with marginal function soon after liver transplantation (LT) and is associated with poor LT outcomes. The impact of EAD on post-LT renal recovery, however, has not been studied. Data on 69 primary LT recipients (41 with and 28 without history of renal dysfunction) who received renal replacement therapy (RRT) for a median (range) of 9 (13-41) days before LT were retrospectively analyzed. Primary outcome was renal nonrecovery defined as RRT requirement 30 days from LT...
April 2018: Transplantation Direct
https://www.readbyqxmd.com/read/29707622/improved-health-related-quality-of-life-in-older-kidney-recipients-1-year-after-transplantation
#9
Kjersti Lønning, Kristian Heldal, Tomm Bernklev, Cathrine Brunborg, Marit Helen Andersen, Nanna von der Lippe, Anna Varberg Reisæter, Pål-Dag Line, Anders Hartmann, Karsten Midtvedt
Background: We aimed to evaluate changes in health-related quality of life (HRQoL) in patients 65 years or older from time of kidney transplantation (KTx) until 1 year postengraftment. Methods: A single-center prospective study was conducted. HRQoL was measured pre-KTx and at 2, 6, and 12 months postengraftment using self-reported Kidney Disease and Quality of Life short-form version 1.3. Intraindividual scores before and after KTx were evaluated. Liu Comorbidity Index was registered at enlisting...
April 2018: Transplantation Direct
https://www.readbyqxmd.com/read/29707621/improved-glucose-tolerance-in-a-kidney-transplant-recipient-with-type-2-diabetes-mellitus-after-switching-from-tacrolimus-to-belatacept-a-case-report-and-review-of-potential-mechanisms
#10
Gretchen N de Graav, Marieke van der Zwan, Carla C Baan, Joop A M J L Janssen, Dennis A Hesselink
The introduction of immunosuppressant belatacept, an inhibitor of the CD28-80/86 pathway, has improved 1-year outcomes in kidney transplant recipients with preexistent diabetes mellitus and has also reduced the risk of posttransplant diabetes mellitus. So far, no studies have compared a tacrolimus-based with a belatacept-based immunosuppressive regimen with regard to improving glucose tolerance after kidney transplantation. Here, we present the case of a 54-year-old man with type 2 diabetes mellitus who was converted from belatacept to tacrolimus 1 year after a successful kidney transplantation...
March 2018: Transplantation Direct
https://www.readbyqxmd.com/read/29707620/outcome-of-patients-with-small-vessel-vasculitis-after-renal-transplantation-national-database-analysis
#11
Amr El-Husseini, Sherif Saleh, Omer Hamad, Xiaonan Mei, Ana Lia Castellanos, Daniel L Davenport, Roberto Gedaly, B Peter Sawaya
Background: Small vessel vasculitis commonly affects the kidney and can progress to end-stage renal disease. The goal of this study is to compare outcomes of patients who received a renal transplant as a result of small vessel vasculitis (group A) with those who received kidney transplants because of other causes (group B). Methods: This is a retrospective analysis of United Network for Organ Sharing registry data for adult primary kidney transplants from January 2000 to December 2014...
March 2018: Transplantation Direct
https://www.readbyqxmd.com/read/29707619/differences-in-proinflammatory-cytokines-and-monocyte-subtypes-in-older-as-compared-with-younger-kidney-transplant-recipients
#12
Emily C Liang, Maura Rossetti, Tiffany Sidwell, Victoria Groysberg, Gema Sunga, Yael Korin, Sitaram Vangala, Basmah Abdalla, Erik Lum, Suphamai Bunnapradist, Phuong-Thu Pham, Gabriel Danovitch, Elaine F Reed, Joanna Schaenman
Background: The number of elderly patients with end-stage kidney disease requiring kidney transplantation continues to grow. Evaluation of healthy older adults has revealed proinflammatory changes in the immune system, which are posited to contribute to age-associated illnesses via "inflamm-aging." Immunologic dysfunction is also associated with impaired control of infections. Whether these immunologic changes are found in older kidney transplant recipients is not currently known, but may have important implications for risk for adverse clinical outcomes...
March 2018: Transplantation Direct
https://www.readbyqxmd.com/read/29707618/transplantation-of-a-liver-allograft-from-a-hepatitis-c-virus-seropositive-donor-with-previous-sustained-virologic-response-to-an-uninfected-recipient-suffering-steroid-refractory-acute-graft-rejection-with-no-evidence-of-hcv-transmission
#13
Robert A Mitchell, Trana Hussaini, Alan H Yau, Mel Krajden, Alissa J Wright, Charles H Scudamore, Vladimir Marquez Azalgara, Siegfried R Erb, Eric M Yoshida
Background: The goal of treating chronic hepatitis C virus (HCV) infection is sustained virologic response (SVR). There is concern that despite achieving SVR, replication-competent HCV may be sequestered at low levels within the liver and could theoretically reactivate with immunosuppression. We report transplantation of a HCV-seropositive liver donor, who achieved SVR, into a seronegative patient without HCV reactivation despite profound immunosuppression. Method: Retrospective chart review...
March 2018: Transplantation Direct
https://www.readbyqxmd.com/read/29464207/socioeconomic-inequalities-in-the-kidney-transplantation-process-a-registry-based-study-in-sweden
#14
Ye Zhang, Ulf-G Gerdtham, Helena Rydell, Johan Jarl
Background: Few studies have examined the association between individual-level socioeconomic status and access to kidney transplantation. This study aims to investigate the association between predialysis income and education, and access to (i) the kidney waitlist (first listing), and (ii) kidney transplantation conditional on waitlist placement. Adjustment will be made for a number of medical and nonmedical factors. Methods: The Swedish Renal Register was linked to national registers for adult patients in Sweden who started dialysis during 1995 to 2013...
February 2018: Transplantation Direct
https://www.readbyqxmd.com/read/29464206/improved-cuff-technique-and-intraoperative-detection-of-vascular-complications-for-hind-limb-transplantation-in-mice
#15
Minhyung Kim, Daniel T Fisher, Colin A Powers, Elizabeth A Repasky, Joseph J Skitzki
Background: Vascularized composite tissue allotransplantation (VCA) from a cadaveric donor has now become a clinical reality and the treatment modality of choice for patients with devastating injuries, deformities, and complex tissue defects. However, many VCA patients experience severe toxicities due to the strong immunosuppression required secondary to high antigenicity of the grafts. To improve immunosuppressive protocols for VCA, feasible and reliable preclinical models are necessary...
February 2018: Transplantation Direct
https://www.readbyqxmd.com/read/29464205/pilot-study-of-delayed-icos-icos-l-blockade-with-%C3%AE-cd40-to-modulate-pathogenic-alloimmunity-in-a-primate-cardiac-allograft-model
#16
Natalie A O'Neill, Tianshu Zhang, Gheorghe Braileanu, Xiangfei Cheng, Alena Hershfeld, Wenji Sun, Keith A Reimann, Sia Dahi, Natalia Kubicki, Wessam Hassanein, Christopher Laird, Arielle Cimeno, Agnes M Azimzadeh, Richard N Pierson
Background: Inducible costimulator (ICOS) is rapidly upregulated with T-cell stimulation and may represent an escape pathway for T-cell costimulation in the setting of CD40/CD154 costimulation blockade. Induction treatment exhibited no efficacy in a primate renal allograft model, but rodent transplant models suggest that the addition of delayed ICOS/ICOS-L blockade may prolong allograft survival and prevent chronic rejection. Here, we ask whether ICOS-Ig treatment, timed to anticipate ICOS upregulation, prolongs NHP cardiac allograft survival or attenuates pathogenic alloimmunity...
February 2018: Transplantation Direct
https://www.readbyqxmd.com/read/29464204/tailored-rabbit-antithymocyte-globulin-induction-dosing-for-kidney-transplantation
#17
Namita Singh, Ana P Rossi, Marizela Savic, Ronald J Rubocki, Mark G Parker, John P Vella
Background: Rabbit antithymocyte globulin (rATG) is the most widely used kidney transplant induction immunotherapy in the United States. It was recently Food and Drug Administration approved for this indication with typical dose recommendations of 1.5 mg/kg for up to 7 days given via a central line. Methods: We theorized that reduced rATG dosing when compared with conventional dosing (6-10.5 mg/kg) is safe and effective, leading to development of a risk-stratified treatment protocol...
February 2018: Transplantation Direct
https://www.readbyqxmd.com/read/29464203/rituximab-induction-to-prevent-the-recurrence-of-psc-after-liver-transplantation-the-lessons-learned-from-abo-incompatible-living-donor-liver-transplantation
#18
Yohei Yamada, Ken Hoshino, Yasushi Fuchimoto, Kentaro Matsubara, Taizo Hibi, Hiroshi Yagi, Yuta Abe, Masahiro Shinoda, Minoru Kitago, Hideaki Obara, Takahito Yagi, Hideaki Okajima, Toshimi Kaido, Shinji Uemoto, Tatsuya Suzuki, Keiichi Kubota, Tomoharu Yoshizumi, Yoshihiko Maehara, Yukihiro Inomata, Yuko Kitagawa, Hiroto Egawa, Tatsuo Kuroda
Background: Multiple studies have failed to reveal an effective method for preventing the recurrence of primary sclerosing cholangitis (PSC) after liver transplantation (LTx). A national study conducted in Japan revealed several risk factors for the recurrence after living donor LTx (LDLTx); however, recipients of ABO-blood type incompatible (ABO-I) LTx were excluded from the previous analysis. In the present study, we investigated the efficacy of an immunosuppressive protocol in ABO-I LTx on the recurrence of PSC after LDLTx...
February 2018: Transplantation Direct
https://www.readbyqxmd.com/read/29464202/prevalence-and-clinical-correlates-of-chronic-hepatitis-e-infection-in-german-renal-transplant-recipients-with-elevated-liver-enzymes
#19
Mira Choi, Jörg Hofmann, Anja Köhler, Bo Wang, Claus-Thomas Bock, Eckart Schott, Petra Reinke, Peter Nickel
Background: Elevated liver enzymes are frequently observed in renal transplant recipients and warrant further exploration. In immunosuppressed patients, hepatitis E virus (HEV) infection may cause chronic hepatitis, cirrhosis, and extrahepatic manifestations such as renal injury. Methods: We performed a retrospective cross-sectional study investigating the prevalence, clinical correlates, and outcome of chronic HEV infection in a cohort of renal transplant recipients with elevated liver enzymes...
February 2018: Transplantation Direct
https://www.readbyqxmd.com/read/29464201/prediction-of-early-bk-virus-infection-in-kidney-transplant-recipients-by-the-number-of-cells-with-intranuclear-inclusion-bodies-decoy-cells
#20
Yoshiteru Yamada, Tomohiro Tsuchiya, Isao Inagaki, Mitsuru Seishima, Takashi Deguchi
Background: BK virus (BKV) is the cause of nephropathy. Because BKV nephropathy can progress to graft loss, early diagnosis of BKV infection is very important. In this study, we aimed to investigate the utility of quantifying cells with intranuclear inclusion bodies (decoy cells) in urinary sediment for the screening and monitoring of BKV infection in renal transplant recipients at our hospital. Methods: This was a retrospective single-center study. Urine sediment examination was performed at each outpatient visit, and the number of decoy cells was measured in the whole microscopic field...
February 2018: Transplantation Direct
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