journal
https://read.qxmd.com/read/38049879/kidney-tissue-regeneration-using-bioactive-scaffolds-incorporated-with-differentiating-extracellular-vesicles-and-intermediate-mesoderm-cells
#21
JOURNAL ARTICLE
Seung-Gyu Cha, Won-Kyu Rhim, Jun Yong Kim, Eun Hye Lee, Seung Yeon Lee, Jeong Min Park, Jeoung Eun Lee, Hyeji Yoon, Chun Gwon Park, Bum Soo Kim, Tae Gyun Kwon, Youngmi Lee, Dong Ryul Lee, Dong Keun Han
BACKGROUND: To overcome the limitations of current alternative therapies for chronic kidney disease (CKD), tissue engineering-mediated regeneration strategies have demonstrated the possibilities for complete kidney tissue regeneration. Given the challenges associated with the reproducibility of renal basal cells, the incorporation of intermediate mesoderm (IM) cells and bioactive materials to control bioactivities of cells with supported scaffolds should be considered as a viable approach to enable the regeneration of the complex kidney structure via renal differentiation...
December 5, 2023: Biomaterials Research
https://read.qxmd.com/read/38049922/mn-single-atom-nano-multizyme-enabled-nir-ii-photoacoustically-monitored-photothermally-enhanced-ros-storm-for-combined-cancer-therapy
#22
JOURNAL ARTICLE
Xiaozhe Wang, Xiaofeng Ren, Jie Yang, Zican Zhao, Xiaoyu Zhang, Fan Yang, Zheye Zhang, Peng Chen, Liping Li, Ruiping Zhang
RATIONALE: To realize imaging-guided multi-modality cancer therapy with minimal side effects remains highly challenging. METHODS: We devised a bioinspired hollow nitrogen-doped carbon sphere anchored with individually dispersed Mn atoms (Mn/N-HCN) via oxidation polymerization with triton micelle as a soft template, followed by carbonization and annealing. Enzyme kinetic analysis and optical properties were performed to evaluate the imaging-guided photothermally synergized nanocatalytic therapy...
December 4, 2023: Biomaterials Research
https://read.qxmd.com/read/38031117/post-insertion-technique-to-introduce-targeting-moieties-in-milk-exosomes-for-targeted-drug-delivery
#23
JOURNAL ARTICLE
Hochung Jang, Hyosuk Kim, Eun Hye Kim, Geonhee Han, Yeongji Jang, Yelee Kim, Jong Won Lee, Sang Chul Shin, Eunice EunKyeong Kim, Sun Hwa Kim, Yoosoo Yang
BACKGROUND: Recently, increased attention has been given on exosomes as ideal nanocarriers of drugs owing to their intrinsic properties that facilitate the transport of biomolecular cargos. However, large-scale exosome production remains a major challenge in the clinical application of exosome-based drug delivery systems. Considering its biocompatibility and stability, bovine milk is a suitable natural source for large-scale and stable exosome production. Because the active-targeting ability of drug carriers is essential to maximize therapeutic efficacy and minimize side effects, precise membrane functionalization strategies are required to enable tissue-specific delivery of milk exosomes with difficulty in post-isolation modification...
November 29, 2023: Biomaterials Research
https://read.qxmd.com/read/38017585/phototherapy-techniques-for-the-management-of-musculoskeletal-disorders-strategies-and-recent-advances
#24
REVIEW
Zhenhe Zhang, Rong Wang, Hang Xue, Samuel Knoedler, Yongtao Geng, Yuheng Liao, Michael Alfertshofer, Adriana C Panayi, Jie Ming, Bobin Mi, Guohui Liu
Musculoskeletal disorders (MSDs), which include a range of pathologies affecting bones, cartilage, muscles, tendons, and ligaments, account for a significant portion of the global burden of disease. While pharmaceutical and surgical interventions represent conventional approaches for treating MSDs, their efficacy is constrained and frequently accompanied by adverse reactions. Considering the rising incidence of MSDs, there is an urgent demand for effective treatment modalities to alter the current landscape...
November 28, 2023: Biomaterials Research
https://read.qxmd.com/read/38008757/mild-heat-treatment-in-vitro-potentiates-human-adipose-stem-cells-delayed-aging-and-improved-quality-for-long-term-culture
#25
JOURNAL ARTICLE
Chiseon Ryu, Minseo Lee, Jae Young Lee
BACKGROUND: Mesenchymal stem cells (MSCs) have gained significant attention for diverse biomedical applications, including cell-based therapy. Hence, in vitro expansion of MSCs is critical; however, in vitro MSC culture, especially long-term culture, inevitably leads to significant loss of stemness, growth, and differentiation potential. METHOD: Effects of mild heat treatment (HT) conditions (temperature, duration, and repetition) on the characteristics of adipose tissue-derived MSCs in vitro were systematically investigated...
November 27, 2023: Biomaterials Research
https://read.qxmd.com/read/38001505/photothermal-therapy-of-copper-incorporated-nanomaterials-for-biomedicine
#26
REVIEW
Rong Wang, Ziwei Huang, Yunxiao Xiao, Tao Huang, Jie Ming
Studies have reported on the significance of copper incorporated nanomaterials (CINMs) in cancer theranostics and tissue regeneration. Given their unique physicochemical properties and tunable nanostructures, CINMs are used in photothermal therapy (PTT) and photothermal-derived combination therapies. They have the potential to overcome the challenges of unsatisfactory efficacy of conventional therapies in an efficient and non-invasive manner. This review summarizes the recent advances in CINMs-based PTT in biomedicine...
November 24, 2023: Biomaterials Research
https://read.qxmd.com/read/37996880/metal-organic-framework-based-photodynamic-combined-immunotherapy-against-the-distant-development-of-triple-negative-breast-cancer
#27
JOURNAL ARTICLE
Xiaoyan Liang, Min Mu, Bo Chen, Rangrang Fan, Haifeng Chen, Bingwen Zou, Bo Han, Gang Guo
BACKGROUND: Triple-negative breast cancer (TNBC) is an aggressive, metastatic and apparently drug-resistant subtype of breast cancer with a higher immune response compared to other types of breast cancer. Photodynamic therapy (PDT) has been gaining popularity for its non-invasive nature, minimal side effects, and spatiotemporally controlled benifits. The use of metal-organic frameworks (MOFs) loaded with programmed death-ligand 1 inhibitors (iPD-L1) offers the possibility of combining PDT with immunotherapy...
November 24, 2023: Biomaterials Research
https://read.qxmd.com/read/37990349/achieving-safe-and-high-performance-gastrointestinal-tract-spectral-ct-imaging-with-small-molecule-lanthanide-complex
#28
JOURNAL ARTICLE
Xiaoling Che, Chunmei Yang, Liping Pan, Didi Gu, Guidong Dai, Jian Shu, Lu Yang
BACKGROUND: Non-intrusive imaging of gastrointestinal (GI) tract using computed tomography (CT) contrast agents is of the most significant issues in the diagnosis and treatment of GI diseases. Moreover, spectral CT, which can generate monochromatic images to display the X-ray attenuation characteristics of contrast agents, provides a better imaging sensitivity for diagnose inflammatory bowel disease (IBD) than convention CT imaging. METHODS: Herein, a convenient and one-pot synthesis method is provided for the fabrication of small-molecule lanthanide complex Holmium-tetraazacyclododecane-1, 4, 7, 10-tetraacetic acid (Ho-DOTA) as a biosafe and high-performance spectral CT contrast agent for GI imaging with IBD...
November 22, 2023: Biomaterials Research
https://read.qxmd.com/read/37981704/an-injectable-in-situ-forming-and-nir-responsive-hydrogel-persistently-reshaping-tumor-microenvironment-for-efficient-melanoma-therapy
#29
JOURNAL ARTICLE
Han Zhang, Liangshan Hu, Wei Xiao, Yanqiong Su, Donglin Cao
BACKGROUND: Melanoma is a highly aggressive form of skin cancer with increasing incidence and mortality rates. Chemotherapy, the primary treatment for melanoma, is limited by hypoxia-induced drug resistance and suppressed immune response at the tumor site. Modulating the tumor microenvironment (TME) to alleviate hypoxia and enhance immune response has shown promise in improving chemotherapy outcomes. METHODS: In this study, a novel injectable and in situ forming hydrogel named MD@SA was developed using manganese dioxide (MnO2 ) nanosheets pre-loaded with the chemotherapy drug doxorubicin (DOX) and mixed with sodium alginate (SA)...
November 19, 2023: Biomaterials Research
https://read.qxmd.com/read/37978399/silk-fibroin-gelatin-and-human-placenta-extracellular-matrix-based-composite-hydrogels-for-3d-bioprinting-and-soft-tissue-engineering
#30
JOURNAL ARTICLE
Karl Heinrich Schneider, Benjamin J Goldberg, Onur Hasturk, Xuan Mu, Marvin Dötzlhofer, Gabriela Eder, Sophia Theodossiou, Luis Pichelkastner, Peter Riess, Sabrina Rohringer, Herbert Kiss, Andreas H Teuschl-Woller, Vincent Fitzpatrick, Marjan Enayati, Bruno K Podesser, Helga Bergmeister, David L Kaplan
BACKGROUND: There is a great clinical need and it remains a challenge to develop artificial soft tissue constructs that can mimic the biomechanical properties and bioactivity of natural tissue. This is partly due to the lack of suitable biomaterials. Hydrogels made from human placenta offer high bioactivity and represent a potential solution to create animal-free 3D bioprinting systems that are both sustainable and acceptable, as placenta is widely considered medical waste. A combination with silk and gelatin polymers can bridge the biomechanical limitations of human placenta chorion extracellular matrix hydrogels (hpcECM) while maintaining their excellent bioactivity...
November 17, 2023: Biomaterials Research
https://read.qxmd.com/read/37968707/application-of-advanced-biomaterials-in-photothermal-therapy-for-malignant-bone-tumors
#31
REVIEW
Bo Chao, Jianhang Jiao, Lili Yang, Yang Wang, Weibo Jiang, Tong Yu, Linfeng Wang, He Liu, Han Zhang, Zhonghan Wang, Minfei Wu
Malignant bone tumors are characterized by severe disability rate, mortality rate, and heavy recurrence rate owing to the complex pathogenesis and insidious disease progression, which seriously affect the terminal quality of patients' lives. Photothermal therapy (PTT) has emerged as an attractive adjunctive treatment offering prominent hyperthermal therapeutic effects to enhance the effectiveness of surgical treatment and avoid recurrence. Simultaneously, various advanced biomaterials with photothermal capacity are currently created to address malignant bone tumors, performing distinctive biological functions, including nanomaterials, bioceramics (BC), polymers, and hydrogels et al...
November 15, 2023: Biomaterials Research
https://read.qxmd.com/read/37950330/recent-advances-in-surface-mounted-metal-organic-framework-thin-film-coatings-for-biomaterials-and-medical-applications-a-review
#32
REVIEW
Mohammad Mehdi Sabzehmeidani, Mahmood Kazemzad
Coatings of metal-organic frameworks (MOFs) have potential applications in surface modification for medical implants, tissue engineering, and drug delivery systems. Therefore, developing an applicable method for surface-mounted MOF engineering to fabricate protective coating for implant tissue engineering is a crucial issue. Besides, the coating process was desgined for drug infusion and effect opposing chemical and mechanical resistance. In the present review, we discuss the techniques of MOF coatings for medical application in both in vitro and in vivo in various systems such as in situ growth of MOFs, dip coating of MOFs, spin coating of MOFs, Layer-by-layer methods, spray coating of MOFs, gas phase deposition of MOFs, electrochemical deposition of MOFs...
November 10, 2023: Biomaterials Research
https://read.qxmd.com/read/37946294/correction-non-interfacial-self-assembly-of-synthetic-protocells
#33
Xiaolin Xu, Wencai Guan, Xiaolei Yu, Guoxiong Xu, Chenglong Wang
No abstract text is available yet for this article.
November 9, 2023: Biomaterials Research
https://read.qxmd.com/read/37946275/tumor-derived-systems-as-novel-biomedical-tools-turning-the-enemy-into-an-ally
#34
REVIEW
Nimeet Desai, Pratik Katare, Vaishali Makwana, Sagar Salave, Lalitkumar K Vora, Jyotsnendu Giri
Cancer is a complex illness that presents significant challenges in its understanding and treatment. The classic definition, "a group of diseases characterized by the uncontrolled growth and spread of abnormal cells in the body," fails to convey the intricate interaction between the many entities involved in cancer. Recent advancements in the field of cancer research have shed light on the role played by individual cancer cells and the tumor microenvironment as a whole in tumor development and progression. This breakthrough enables the utilization of the tumor and its components as biological tools, opening new possibilities...
November 9, 2023: Biomaterials Research
https://read.qxmd.com/read/37941059/precise-visualization-and-ros-dependent-photodynamic-therapy-of-colorectal-cancer-with-a-novel-mitochondrial-viscosity-photosensitive-fluorescent-probe
#35
JOURNAL ARTICLE
Runsha Xiao, Fan Zheng, Kuo Kang, Lei Xiao, Anyao Bi, Yiting Chen, Qi Zhou, Xueping Feng, Zhikang Chen, Hao Yin, Wei Wang, Zihua Chen, Xiaomiao Cheng, Wenbin Zeng
BACKGROUND: Colorectal cancer (CRC) is a prominent global cancer with high mortality rates among human beings. Efficient diagnosis and treatment have always been a challenge for CRC management. Fluorescence guided cancer therapy, which combines diagnosis with therapy into one platform, has brought a new chance for achieving precise cancer theranostics. Among this, photosensitizers, applied in photodynamic therapy (PDT), given the integration of real-time imaging capacity and efficacious treatment feasibility, show great potential to serve as remarkable tools...
November 8, 2023: Biomaterials Research
https://read.qxmd.com/read/37932837/fabrication-of-a-three-dimensional-bone-marrow-niche-like-acute-myeloid-leukemia-disease-model-by-an-automated-and-controlled-process-using-a-robotic-multicellular-bioprinting-system
#36
JOURNAL ARTICLE
Dana M Alhattab, Ioannis Isaioglou, Salwa Alshehri, Zainab N Khan, Hepi H Susapto, Yanyan Li, Yara Marghani, Arwa A Alghuneim, Rubén Díaz-Rúa, Sherin Abdelrahman, Shuroug Al-Bihani, Farid Ahmed, Raed I Felimban, Heba Alkhatabi, Raed Alserihi, Malak Abedalthagafi, AlShaibani AlFadel, Abdalla Awidi, Adeel Gulzar Chaudhary, Jasmeen Merzaban, Charlotte A E Hauser
BACKGROUND: Acute myeloid leukemia (AML) is a hematological malignancy that remains a therapeutic challenge due to the high incidence of disease relapse. To better understand resistance mechanisms and identify novel therapies, robust preclinical models mimicking the bone marrow (BM) microenvironment are needed. This study aimed to achieve an automated fabrication process of a three-dimensional (3D) AML disease model that recapitulates the 3D spatial structure of the BM microenvironment and applies to drug screening and investigational studies...
November 6, 2023: Biomaterials Research
https://read.qxmd.com/read/37925456/polymer-composite-microspheres-loading-177-lu-radionuclide-for-interventional-radioembolization-therapy-and-real-time-spect-imaging-of-hepatic-cancer
#37
JOURNAL ARTICLE
Liu Xiao, Yuhao Li, Ruiman Geng, Lihong Chen, Peng Yang, Mingyu Li, Xia Luo, Yuchuan Yang, Lin Li, Huawei Cai
BACKGROUND: Transarterial radioembolization (TARE) with 90 Y-labeled glass and resin microspheres is one of the primary treatment strategies for advanced-stage primary and metastatic hepatocellular carcinoma (HCC). However, difficulties of real-time monitoring post administration and embolic hypoxia influence treatment prognosis. In this study, we developed a new biodegradable polymer microsphere that can simultaneously load 177 Lu and MgO nanoparticle, and evaluated the TARE therapeutic efficacy and biosafety of 177 Lu-PDA-CS-MgO microspheres for HCC treatment...
November 4, 2023: Biomaterials Research
https://read.qxmd.com/read/37924106/reduced-graphene-oxide-coated-alginate-scaffolds-potential-for-cardiac-patch-application
#38
JOURNAL ARTICLE
Nafiseh Baheiraei, Mehdi Razavi, Ramin Ghahremanzadeh
BACKGROUND: Cardiovascular diseases, particularly myocardial infarction (MI), are the leading cause of death worldwide and a major contributor to disability. Cardiac tissue engineering is a promising approach for preventing functional damage or improving cardiac function after MI. We aimed to introduce a novel electroactive cardiac patch based on reduced graphene oxide-coated alginate scaffolds due to the promising functional behavior of electroactive biomaterials to regulate cell proliferation, biocompatibility, and signal transition...
November 4, 2023: Biomaterials Research
https://read.qxmd.com/read/37908012/nanoarchitectonics-of-tannic-acid-based-injectable-hydrogel-regulate-the-microglial-phenotype-to-enhance-neuroplasticity-for-poststroke-rehabilitation
#39
JOURNAL ARTICLE
Zongjian Liu, Shulei Zhang, Yuanyuan Ran, Huimin Geng, Fuhai Gao, Guiqin Tian, Zengguo Feng, Jianing Xi, Lin Ye, Wei Su
BACKGROUND: Stroke is the second leading cause of mortality and disability worldwide. Poststroke rehabilitation is still unsatisfactory in clinics, which brings great pain and economic burdens to stroke patients. In this study, an injectable hydrogel in which tannic acid (TA) acts as not only a building block but also a therapeutic drug, was developed for poststroke rehabilitation. METHODS: TA is used as a building block to form an injectable hydrogel (TA gel) with carboxymethyl chitosan (CMCS) by multivalent hydrogen bonds...
October 31, 2023: Biomaterials Research
https://read.qxmd.com/read/37904248/correction-high-glutathione-mesenchymal-stem-cells-isolated-using-the-freshtracer-probe-enhance-cartilage-regeneration-in-a-rabbit-chondral-defect-model
#40
Gun Hee Cho, Hyun Cheol Bae, Won Young Cho, Eui Man Jeong, Hee Jung Park, Ha Ru Yang, Sun Young Wang, You Jung Kim, Dong Myung Shin, Hyung Min Chung, In Gyu Kim, Hyuk-Soo Han
No abstract text is available yet for this article.
October 31, 2023: Biomaterials Research
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