Dana M Alhattab, Ioannis Isaioglou, Salwa Alshehri, Zainab N Khan, Hepi H Susapto, Yanyan Li, Yara Marghani, Arwa A Alghuneim, Rubén Díaz-Rúa, Sherin Abdelrahman, Shuroug Al-Bihani, Farid Ahmed, Raed I Felimban, Heba Alkhatabi, Raed Alserihi, Malak Abedalthagafi, AlShaibani AlFadel, Abdalla Awidi, Adeel Gulzar Chaudhary, Jasmeen Merzaban, Charlotte A E Hauser
BACKGROUND: Acute myeloid leukemia (AML) is a hematological malignancy that remains a therapeutic challenge due to the high incidence of disease relapse. To better understand resistance mechanisms and identify novel therapies, robust preclinical models mimicking the bone marrow (BM) microenvironment are needed. This study aimed to achieve an automated fabrication process of a three-dimensional (3D) AML disease model that recapitulates the 3D spatial structure of the BM microenvironment and applies to drug screening and investigational studies...
November 6, 2023: Biomaterials Research