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Biomaterials Research

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https://www.readbyqxmd.com/read/30065849/theranostics-and-contrast-agents-for-magnetic-resonance-imaging
#1
REVIEW
Yohan Jeong, Hee Sook Hwang, Kun Na
Background: Magnetic resonance imaging is one of the diagnostic tools that uses magnetic particles as contrast agents. It is noninvasive methodology which provides excellent spatial resolution. Although magnetic resonance imaging offers great temporal and spatial resolution and rapid in vivo images acquisition, it is less sensitive than other methodologies for small tissue lesions, molecular activity or cellular activities. Thus, there is a desire to develop contrast agents with higher efficiency...
2018: Biomaterials Research
https://www.readbyqxmd.com/read/30065848/antibody-mediated-oral-delivery-of-therapeutic-dna-for-type-2-diabetes-mellitus
#2
Seungbin Cha, Sun Hwa Lee, Sung Hun Kang, Mohammad Nazmul Hasan, Young Jun Kim, Sungpil Cho, Yong-Kyu Lee
Background: Diabetes mellitus (DM) is a chronic progressive metabolic disease that involves uncontrolled elevation of blood glucose levels. Among various therapeutic approaches, GLP-1 prevents type 2 diabetes mellitus (T2DM) patients from experiencing hyperglycemic episodes. However, the short half-life (< 5 min) and rapid clearance of GLP-1 often limits its therapeutic use. Here, we developed an oral GLP-1 gene delivery system to achieve an extended antidiabetic effect. Methods: Human IgG1 (hIgG1)-Fc-Arg/pDNA complexes were prepared by an electrostatic complexation of the expression plasmid with various ratios of the positively modified Fc fragments of an antibody (hIgG1-Fc-Arg) having a targeting ability to FcRn receptor...
2018: Biomaterials Research
https://www.readbyqxmd.com/read/30038795/classification-of-gallstones-using-fourier-transform-infrared-spectroscopy-and-photography
#3
Byeong Jo Ha, Sangsoo Park
Background: Gallstones have conventionally been classified by gross inspection into 4 categories: cholesterol gallstones, black pigment (calcium bilirubinate) gallstones, brown gallstones, and mixed gallstones that contain both cholesterol and calcium bilirubinate. Classification using Fourier-transform infrared (FT-IR) spectroscopy supplements gross inspection; however, the issue of ambiguity in gallstone classification has not been fully addressed to date. Methods: Twenty-six gallstones obtained after surgical gallbladder removal were examined using FT-IR spectroscopy and digital photography, and classified into 6 gallstone groups according to characteristic FT-IR absorption bands...
2018: Biomaterials Research
https://www.readbyqxmd.com/read/29942642/synthesis-of-a-gadolinium-based-macrocyclic-mri-contrast-agent-for-effective-cancer-diagnosis
#4
Yohan Jeong, Kun Na
Background: Gadolinium-based contrast agents are widely used as a contrast agent for magnetic resonance imaging. Since gadolinium ions are toxic, many chelators are developed to bind gadolinium ions to prevent free gadolinium-associated disease. However, many reports indicated that linear chelator-based contrast agents are associated with nephrogenic systemic fibrosis (NSF) in patients with low kidney function. Therefore, the demand for stable macrocyclic chelator-based contrast agent is now increasing...
2018: Biomaterials Research
https://www.readbyqxmd.com/read/29862039/fabrication-and-optimization-of-nanodiamonds-composited-poly-%C3%AE%C2%B5-caprolactone-fibrous-matrices-for-potential-regeneration-of-hard-tissues
#5
Guk Young Ahn, Tae-Kyung Ryu, Yu Ri Choi, Ju Ri Park, Min Jeong Lee, Sung-Wook Choi
Background: Electrospun fibrous matrices are of great importance for tissue engineering and drug delivery device. However, relatively low mechanical strength of the fibrous matrix is one of the major disadvantages. NDs with a positive charge were selected to enhance the mechanical property of a composited fibrous matrix by inducing the intermolecular interaction between NDs and polymer chain. We prepared ND-composited poly (ε-caprolactone) (PCL) fibrous matrices by electrospinning and evaluated their performance in terms of mechanical strength and cell behaviors...
2018: Biomaterials Research
https://www.readbyqxmd.com/read/29799540/retraction-note-fabrication-of-a-microfluidic-device-for-studying-the-in-situ-drug-loading-release-behavior-of-graphene-oxide-encapsulated-hydrogel-beads
#6
Sarath Chandra Veerla, Da Reum Kim, Sung Yun Yang
[This retracts the article DOI: 10.1186/s40824-018-0119-9.].
2018: Biomaterials Research
https://www.readbyqxmd.com/read/29780613/schwann-cell-durotaxis-can-be-guided-by-physiologically-relevant-stiffness-gradients
#7
Elisabeth B Evans, Samantha W Brady, Anubhav Tripathi, Diane Hoffman-Kim
Background: Successful nerve regeneration depends upon directed migration of morphologically specialized repair state Schwann cells across a nerve defect. Although several groups have studied directed migration of Schwann cells in response to chemical or topographic cues, the current understanding of how the mechanical environment influences migration remains largely understudied and incomplete. Therefore, the focus of this study was to evaluate Schwann cell migration and morphodynamics in the presence of stiffness gradients, which revealed that Schwann cells can follow extracellular gradients of increasing stiffness, in a form of directed migration termed durotaxis...
2018: Biomaterials Research
https://www.readbyqxmd.com/read/29760942/induction-of-chondrogenesis-of-human-placenta-derived-mesenchymal-stem-cells-via-heparin-grafted-human-fibroblast-derived-matrix
#8
Yong Kwan Noh, Ping Du, Avelino Dos Santos Da Costa, Kwideok Park
Background: Formation of mature and functional articular cartilage is still challenging in cartilage tissue engineering. This study investigates the potential of using heparin-grafted decellularized extracellular matrix (ECM) as a novel growth factor delivery platform towards human placenta-derived mesenchymal stem cells (hPMSCs) chondrogenic differentiation. Human fibroblast-derived extracellular matrix (hFDM) is naturally obtained from in vitro-cultured human lung fibroblasts via a mild decellularization process...
2018: Biomaterials Research
https://www.readbyqxmd.com/read/29686885/application-of-click-chemistry-in-nanoparticle-modification-and-its-targeted-delivery
#9
REVIEW
Gawon Yi, Jihwan Son, Jihye Yoo, Changhee Park, Heebeom Koo
Background: Click chemistry is termed as a group of chemical reactions with favorable reaction rate and orthogonality. Recently, click chemistry is paving the way for novel innovations in biomedical science, and nanoparticle research is a representative example where click chemistry showed its promising potential. Challenging trials with nanoparticles has been reported based on click chemistry including copper-catalyzed cycloaddition, strain-promoted azide-alkyne cycloaddition, and inverse-demand Diels-Alder reaction...
2018: Biomaterials Research
https://www.readbyqxmd.com/read/29636985/recent-trends-in-bioinks-for-3d-printing
#10
REVIEW
Janarthanan Gopinathan, Insup Noh
Background: The worldwide demand for the organ replacement or tissue regeneration is increasing steadily. The advancements in tissue engineering and regenerative medicine have made it possible to regenerate such damaged organs or tissues into functional organ or tissue with the help of 3D bioprinting. The main component of the 3D bioprinting is the bioink, which is crucial for the development of functional organs or tissue structures. The bioinks used in 3D printing technology require so many properties which are vital and need to be considered during the selection...
2018: Biomaterials Research
https://www.readbyqxmd.com/read/29619243/two-dimensional-material-based-bionano-platforms-to-control-mesenchymal-stem-cell-differentiation
#11
REVIEW
Ee-Seul Kang, Da-Seul Kim, Intan Rosalina Suhito, Wanhee Lee, Inbeom Song, Tae-Hyung Kim
Background: In the past decade, stem cells, with their ability to differentiate into various types of cells, have been proven to be resourceful in regenerative medicine and tissue engineering. Despite the ability to repair damaged parts of organs and tissues, the use of stem cells still entails several limitations, such as low differentiation efficiency and difficulties in guiding differentiation. To address these limitations, nanotechnology approaches have been recently implemented in stem cell research...
2018: Biomaterials Research
https://www.readbyqxmd.com/read/29568558/regulation-of-lubricin-for-functional-cartilage-tissue-regeneration-a-review
#12
REVIEW
Yunsup Lee, Jaehoon Choi, Nathaniel S Hwang
Background: Lubricin is chondrocyte-secreted glycoprotein that primarily conducts boundary lubrication between joint surfaces. Besides its cytoprotective function and extracellular matrix (ECM) attachment, lubricin is recommended as a novel biotherapeutic protein that restore functional articular cartilage. Likewise, malfunction of lubrication in damaged articular cartilage caused by complex and multifaceted matter is a major concern in the field of cartilage tissue engineering. Main body: Although a noticeable progress has been made toward cartilage tissue regeneration through numerous approaches such as autologous chondrocyte implantation, osteochondral grafts, and microfracture technique, the functionality of engineered cartilage is a challenge for complete reconstruction of cartilage...
2018: Biomaterials Research
https://www.readbyqxmd.com/read/29564151/analysis-of-trends-and-prospects-regarding-stents-for-human-blood-vessels
#13
Jeong Hee Lee, Eung Do Kim, Eun Jung Jun, Hyoung Sun Yoo, Joon Woo Lee
Background: The purpose of this paper is to provide technology trends and information regarding market and prospects in stents used for human blood vessels in Korea and the world.A stent is a medical device in the form of a cylindrical metal net used to normalize flow when blood or other bodily fluids such as biliary fluids are obstructed in blood vessels, gastrointestinal tracts, etc. by inserting the stent into a narrowed or clogged area. Stents are classified into vascular and non-vascular stents...
2018: Biomaterials Research
https://www.readbyqxmd.com/read/29564150/fabrication-of-a-microfluidic-device-for-studying-the-in-situ-drug-loading-release-behavior-of-graphene-oxide-encapsulated-hydrogel-beads
#14
Sarath Chandra Veerla, Da Reum Kim, Sung Yun Yang
Background: Controlled drug delivery system is highly important for not only prolonged the efficacy of drug but also cellular development for tissue engineering. A number of biopolymer composites and nanostructured carriers behave been used for the controlled drug delivery of therapeutics. Recently, in vitro microfluidic devices that mimic the human body have been developed for drug-delivery applications. Methods: A microfluidic channel was fabricated via a two-step process: (i) polydimethyl siloxane (PDMS) and curing agent were poured with a 10:2 mass ratio onto an acrylic mold with two steel pipes, and (ii) calcium alginate beads were synthesized using sodium alginate and calcium chloride solutions...
2018: Biomaterials Research
https://www.readbyqxmd.com/read/29556415/the-effect-of-serum-types-on-chondrogenic-differentiation-of-adipose-derived-stem-cells
#15
Hyeran Cho, Aeri Lee, Kyobum Kim
Background: Fetal bovine serum (FBS) is the most essential supplement in culture media for cellular proliferation, metabolism, and differentiation. However, due to a limited supply and subsequently rising prices, a series of studies have investigated a biological feasibility of replaceable serums to substitute FBS. Along with the increasing interests to manufacture stem cell-based cellular products, optimizing the composition of culture media including serums and exogenous growth factors (GFs) is of importance...
2018: Biomaterials Research
https://www.readbyqxmd.com/read/29497562/ferritin-nanoparticles-for-improved-self-renewal-and-differentiation-of-human-neural-stem-cells
#16
Jung Seung Lee, Kisuk Yang, Ann-Na Cho, Seung-Woo Cho
Background: Biomaterials that promote the self-renewal ability and differentiation capacity of neural stem cells (NSCs) are desirable for improving stem cell therapy to treat neurodegenerative diseases. Incorporation of micro- and nanoparticles into stem cell culture has gained great attention for the control of stem cell behaviors, including proliferation and differentiation. Method: In this study, ferritin, an iron-containing natural protein nanoparticle, was applied as a biomaterial to improve the self-renewal and differentiation of NSCs and neural progenitor cells (NPCs)...
2018: Biomaterials Research
https://www.readbyqxmd.com/read/29484201/differentiated-osteoblasts-derived-decellularized-extracellular-matrix-to-promote-osteogenic-differentiation
#17
Jin Jeon, Min Suk Lee, Hee Seok Yang
Background: The extracellular matrix (ECM) can directly or indirectly influence on regulation of cell functions such as cell adhesion, migration, proliferation and differentiation. The cell derived ECM (CD-ECM) is a useful in vitro model for studying the comprehensive functions of CD-ECM because it maintains a native-like structure and composition. In this study, the CD-ECM is obtained and a test is carried out to determine the effectiveness of several combinations of decellularized methods...
2018: Biomaterials Research
https://www.readbyqxmd.com/read/29449959/sulfobetaine-methacrylate-hydrogel-coated-anti-fouling-surfaces-for-implantable-biomedical-devices
#18
Se Yeong Lee, Yunki Lee, Phuong Le Thi, Dong Hwan Oh, Ki Dong Park
Background: Zwitterionic molecules have been widely studied as coating materials for preparing anti-fouling surfaces because they possess strong hydration properties that can resist non-specific protein adsorption. Numerous studies on surface modification using zwitterionic molecules have been investigated, such as electrochemically mediated and photoinitiated radical polymerization. However, these methods have some limitations, including multi-step process, difficulties in producing thick and dense layers as well as the requirement of extra facilities...
2018: Biomaterials Research
https://www.readbyqxmd.com/read/29372072/the-market-trend-analysis-and-prospects-of-cancer-molecular-diagnostics-kits
#19
Ju Hwan Seo, Joon Woo Lee, Daemyeong Cho
Background: The molecular diagnostics market can be broadly divided into PCR (rt-PCR, d-PCR), NGS(Next Generation Sequencing), Microarray, FISH(Fluorescent in situ-hybridization) and other categories, based on the diagnostic technique. Also, depending on the disease being diagnosed, the market can also be divided into cancer, infectious diseases, HIV/STDs (herpes, syphilis), and women's health issues such as breast cancer, cervical cancer, ovarian cancer, HPV(human papillomavirus), and vaginitis...
2018: Biomaterials Research
https://www.readbyqxmd.com/read/29308274/enhanced-osteogenic-commitment-of-murine-mesenchymal-stem-cells-on-graphene-oxide-substrate
#20
Jiyong Kim, Hwan D Kim, Jungha Park, Eun-Seo Lee, Eugene Kim, Seunghun S Lee, Jin-Kyung Yang, Yoon-Sik Lee, Nathaniel S Hwang
Background: Tissue engineering is an interdisciplinary field that attempts to restore or regenerate tissues and organs through biomimetic fabrication of scaffolds with specific functionality. In recent years, graphene oxide (GO) is considered as promising biomaterial due to its nontoxicity, high dispersity, and hydrophilic interaction, and these characteristics are key to stimulating the interactions between substrates and cells. Method: In this study, GO substrates were fabricated via chemically immobilizing GO at 1...
2018: Biomaterials Research
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