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Biomaterials Research

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https://www.readbyqxmd.com/read/28529764/in-vivo-analysis-of-covering-materials-composed-of-biodegradable-polymers-enriched-with-flax-fibers
#1
Tomasz Gredes, Sandra Schönitz, Tomasz Gedrange, Lukas Stepien, Karol Kozak, Christiane Kunert-Keil
BACKGROUND: The objective of this study was to investigate the in vivo effect of bioactive composites with poly(lactic acid) (PLA) or polycaprolactone (PCL) as the matrix, reinforced with bioplastic flax fibers, on the surrounding muscle tissue. METHODS: Materials of pure PLA and PCL and their composites with flax fibers from genetically modified plants producing poly-3-hydroxybutyrate (PLA-transgen, PCL-transgen) and unmodified plants (PLA-wt, PCL-wt) were placed subcutaneous on the M...
2017: Biomaterials Research
https://www.readbyqxmd.com/read/28529763/characterisation-of-a-novel-poly-ether-ether-ketone-calcium-sulphate-composite-for-bone-augmentation
#2
Erik A B Hughes, Liam M Grover
BACKGROUND: Calcium sulphate (CS) has been used in bone grafting since the 1800s. It has not replaced autograft as the gold standard, however, since its dissolution occurs rapidly in bodily fluids, meaning that the material cannot support long-term bone growth. Here, the polymer poly (ether ether ketone) (PEEK) was used to slow dissolution in in vitro physiological environments and augment the mechanical properties of the material. METHODS: PEEK/CS specimens were fabricated by combining powders of PEEK and CS with water, resulting in a hardening paste...
2017: Biomaterials Research
https://www.readbyqxmd.com/read/28439422/anti-aging-effect-and-gene-expression-profiling-of-dung-beetle-glycosaminoglycan-in-aged-rats
#3
Mi Young Ahn, Ban Ji Kim, Ha Jeong Kim, Jae Sam Hwang, Yi-Sook Jung, Kun-Koo Park
BACKGROUND: This study aimed to evaluate the anti-aging effect of a newly prepared insect-derived compound, dung beetle glycosaminoglycan (GAG), given intraperitoneally to old SD rats as part of their diet for 1 month. Insect GAG administration was found to be related to a reduction in oxidative damage, hepato-cellular biomarker levels, protein carbonyl content, and malondialdehyde concentration. The anti-aging-related molecular genetic mechanisms of dung beetle GAG are not yet fully elucidated...
2017: Biomaterials Research
https://www.readbyqxmd.com/read/28435697/calcium-phosphates-and-silicon-exploring-methods-of-incorporation
#4
Ana I Rodrigues, Rui L Reis, Clemens A van Blitterswijk, Isabel B Leonor, Pamela Habibović
BACKGROUND: Bioinorganics have been explored as additives to ceramic bone graft substitutes with the aim to improve their performance in repair and regeneration of large bone defects. Silicon (Si), an essential trace element involved in the processes related to bone formation and remodeling, was shown not only to enhance osteoblasts proliferation but also to stimulate the differentiation of mesenchymal stem cells (MSCs) and preosteoblasts into the osteogenic lineage. In this study, the added value of Si to calcium phosphate (CaP) coatings was evaluated...
2017: Biomaterials Research
https://www.readbyqxmd.com/read/28405467/anti-apoptotic-effect-of-dexamethasone-in-an-ototoxicity-model
#5
Jin Ho Lee, Se Heang Oh, Tae Ho Kim, Yoon Young Go, Jae-Jun Song
BACKGROUND: Dexamethasone (DEX) is used for the treatment of various inner ear diseases. However, the molecular mechanism of DEX on gentamicin induced hair cell damage is not known. Therefore, this study investigated the protective effect of DEX on gentamicin (GM)-induced ototoxicity and the effect of GM on the expression of apoptosis related genes. METHODS: The protective effects of DEX were measured by phalloidin staining of explant cultures of organ of Corti from postnatal day 2-3 mice with GM-induced hair cell loss...
2017: Biomaterials Research
https://www.readbyqxmd.com/read/28396799/erratum-to-umbilical-cord-mesenchymal-stem-cells-derived-extracellular-vesicles-can-safely-ameliorate-the-progression-of-chronic-kidney-diseases
#6
Wael Nassar, Mervat El-Ansary, Dina Sabry, Mostafa A Mostafa, Tarek Fayad, Esam Kotb, Mahmoud Temraz, Abdel-Naser Saad, Wael Essa, Heba Adel
[This corrects the article DOI: 10.1186/s40824-016-0068-0.].
2017: Biomaterials Research
https://www.readbyqxmd.com/read/28250967/osteogenesis-evaluation-of-duck-s-feet-derived-collagen-hydroxyapatite-sponges-immersed-in-dexamethasone
#7
Yeon Ji Kook, Dae Hoon Lee, Jeong Eun Song, Nirmalya Tripathy, Yoo Shin Jeon, Ha Yan Jeon, Joaquim M Oliveira, Rui L Reis, Gilson Khang
BACKGROUND: The aim of this study was to investigate the osteogenesis effects of DC and DC/HAp sponge immersed in without and with dexamethasone. METHODS: The experimental groups in this study were DC and DC/HAp sponge immersed in without dexamethasone (Dex(-)DC and Dex(-)-DC/HAp group) and with dexamethasone (Dex(+)-DC and Dex(+)-DC/HAp group). We characterized DC and DC/HAp sponge using compressive strength, scanning electron microscopy (SEM). Also, osteogenic differentiation of BMSCs on sponge (Dex(-)DC, Dex(-)-DC/HAp, Dex(+)-DC and Dex(+)-DC/HAp group) was assessed by SEM, 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazoliumbromide (MTT) assay, alkaline phosphatase (ALP) activity assay and reverse transcription-PCR (RT-PCR)...
2017: Biomaterials Research
https://www.readbyqxmd.com/read/28097017/study-of-myoblast-differentiation-using-multi-dimensional-scaffolds-consisting-of-nano-and-micropatterns
#8
Sung Ho Cha, Hyun Jong Lee, Won-Gun Koh
BACKGROUND: The topographical cue is major influence on skeletal muscle cell culture because the structure is highly organized and consists of long parallel bundles of multinucleated myotubes that are formed by differentiation and fusion of myoblast satellite cells. In this technical report, we fabricated a multiscale scaffold using electrospinning and poly (ethylene glycol) (PEG) hydrogel micropatterns to monitor the cell behaviors on nano- and micro-alignment combined scaffolds with different combinations of angles...
2017: Biomaterials Research
https://www.readbyqxmd.com/read/27980804/direct-reprogramming-and-biomaterials-for-controlling-cell-fate
#9
REVIEW
Eunsol Kim, Giyoong Tae
Direct reprogramming which changes the fate of matured cell is a very useful technique with a great interest recently. This approach can eliminate the drawbacks of direct usage of stem cells and allow the patient specific treatment in regenerative medicine. Overexpression of diverse factors such as general reprogramming factors or lineage specific transcription factors can change the fate of already differentiated cells. On the other hand, biomaterials can provide physical and topographical cues or biochemical cues on cells, which can dictate or significantly affect the differentiation of stem cells...
2016: Biomaterials Research
https://www.readbyqxmd.com/read/27980803/erratum-to-superior-absorption-and-retention-properties-of-foam-film-silver-dressing-versus-other-commercially-available-silver-dressing
#10
Seung Moon Lee, Il Kyu Park, Yong Soo Kim, Hyun Jung Kim, Hanlim Moon, Stefan Mueller, Harsha Arumugam, Young-Il Jeong
[This corrects the article DOI: 10.1186/s40824-016-0069-z.].
2016: Biomaterials Research
https://www.readbyqxmd.com/read/27980802/erratum-to-physical-morphological-and-wound-healing-properties-of-a-polyurethane-foam-film-dressing
#11
Seung Moon Lee, Il Kyu Park, Yong Soo Kim, Hyun Jung Kim, Hanlim Moon, Stefan Mueller, Young-Il Jeong
[This corrects the article DOI: 10.1186/s40824-016-0063-5.].
2016: Biomaterials Research
https://www.readbyqxmd.com/read/27895934/liposomal-delivery-systems-for-intestinal-lymphatic-drug-transport
#12
REVIEW
Hyeji Ahn, Ji-Ho Park
Intestinal lymphatic drug delivery has been widely studied because drugs can bypass the first-pass metabolism in the liver via the lymphatic route, which increases oral bioavailability. Various lipid-based nanoparticles have been used to deliver hydrophobic drugs to the lymphatic pathway. This review focuses on the liposomal delivery systems used for intestinal lymphatic drug transport. Liposomal formulations have attracted particular attention because they can stimulate the production of chylomicrons and the incorporated drugs readily associate with enterocyte-derived chylomicrons, enhancing lymphatic drug transport...
2016: Biomaterials Research
https://www.readbyqxmd.com/read/27872752/in-vitro-toxicity-study-of-poly-alkylphenol-as-vulcanizing-agent
#13
Joon Woo Chon, Ji Yun Lee, Yoon Ju Song, Jin Hwan Kim, Dong June Chung
In this study, cytotoxicity of various novel poly(alkylpehnol) derivatives which, one of constituent for vulcanizing agent, could be adjusted in medical elastic rubber applications were investigated under various conditions of cytotoxicity test. By MTT-assay which according to ISO 10993-5 regulation, we could figure out cell viability of mouse fibroblast in various sample conditions. Furthermore, by Live & Dead Cell assay, we could get colorimetric cell viability via fluorescence images.
2016: Biomaterials Research
https://www.readbyqxmd.com/read/27826455/mg-63-cells-proliferation-following-various-types-of-mechanical-stimulation-on-cells-by-auxetic-hybrid-scaffolds
#14
Hong Jin Choi, Jun Jae Lee, Jung Bok Lee, Hak-Joon Sung, Jung-Woog Shin, Ji Won Shin, Yanru Wu, Jeong Koo Kim
BACKGROUND: Mechanical properties and cyto-compatibility of a composite scaffold which possessed negative (-) Poisson's ratio (NPR) was investigated for effective load transfer from auxetic scaffold to cell. METHODS: Organic/inorganic composite scaffolds were prepared by mixing hydroxyapatite (HA) to poly(lactide-co-glycolide) (PLGA). To induce NPR in composite scaffold, 3-directional volumetric compression was applied during the scaffold fabrication at adequate temperature(60°C)...
2016: Biomaterials Research
https://www.readbyqxmd.com/read/27807476/lipid-based-surface-engineering-of-plga-nanoparticles-for-drug-and-gene-delivery-applications
#15
REVIEW
Rajendran Jc Bose, Soo-Hong Lee, Hansoo Park
The use of poly(lactic-co-glycolic acid) (PLGA)-based nanocarriers presents several major challenges, including their synthetic hydrophobic surface, low transfection efficiency, short circulation half-life, and nonspecific tissue distribution. Numerous engineering strategies have been employed to overcome these problems, with lipid-based surface functionalization of PLGA nanoparticles (NPs) showing promising results in the development of PLGA-based clinical nanomedicines. Surface engineering with different lipids enhances the target specificity of the carrier and improves its physicochemical properties as well as NP-cell associations, such as cellular membrane permeability, immune responses, and long circulation half-life in vivo...
2016: Biomaterials Research
https://www.readbyqxmd.com/read/27807475/mg-63-osteoblast-like-cell-proliferation-on-auxetic-plga-scaffold-with-mechanical-stimulation-for-bone-tissue-regeneration
#16
Hong Jin Choi, Jun Jae Lee, Yeong Jun Park, Jung-Woog Shin, Hak-Joon Sung, Ji Won Shin, Yanru Wu, Jeong Koo Kim
BACKGROUND: Auxetic scaffolds (experimental) was fabricated by using poly(D, L-lactic-co-glycolic acid), 50:50, (PLGA) for effective bone cell proliferation with mechanical stimulation. METHODS: Negative Poisson's ratio in scaffold, 3-directional volumetric compression was applied during the scaffold fabrication at adequate temperature (60 °C). The pore size of scaffold ranged between 355 and 400 μm. RESULTS: The porous morphology of the prepared auxetic scaffolds had shown partially concave and dent shapes in SEM image as expected...
2016: Biomaterials Research
https://www.readbyqxmd.com/read/27713832/a-comparative-study-of-enzyme-initiators-for-crosslinking-phenol-functionalized-hydrogels-for-cell-encapsulation
#17
Justine J Roberts, Pratibha Naudiyal, Khoon S Lim, Laura A Poole-Warren, Penny J Martens
BACKGROUND: Dityrosine crosslinking in proteins is a bioinspired method of forming hydrogels. This study compares oxidative enzyme initiators for their relative crosslinking efficiency and cytocompatibility using the same phenol group and the same material platform. Four common enzyme and enzyme-like oxidative initiators were probed for resulting material properties and cell viability post-encapsulation. RESULTS: All four initiators can be used to form phenol-crosslinked hydrogels, however gelation rates are dependent on enzyme type, concentration, and the oxidant...
2016: Biomaterials Research
https://www.readbyqxmd.com/read/27708859/polypyrrole-incorporated-conductive-hyaluronic-acid-hydrogels
#18
Jongcheol Yang, Goeun Choe, Sumi Yang, Hyerim Jo, Jae Young Lee
BACKGROUND: Hydrogels that possess hydrophilic and soft characteristics have been widely used in various biomedical applications, such as tissue engineering scaffolds and drug delivery. Conventional hydrogels are not electrically conductive and thus their electrical communication with biological systems is limited. METHOD: To create electrically conductive hydrogels, we fabricated composite hydrogels of hyaluronic acid and polypyrrole. In particular, we synthesized and used pyrrole-hyaluronic acid-conjugates and further chemically polymerized polypyrrole with the conjugates for the production of conductive hydrogels that can display suitable mechanical and structural properties...
2016: Biomaterials Research
https://www.readbyqxmd.com/read/27606074/a-branched-tat-cell-penetrating-peptide-as-a-novel-delivery-carrier-for-the-efficient-gene-transfection
#19
Chanuk Jeong, Jisang Yoo, DaeYong Lee, Yeu-Chun Kim
BACKGROUND: Cell penetrating peptides (CPPs) as one class of non-viral vectors, have been widely explored as a delivery tool due to their cell-penetrating capability with low cytotoxicity. However, CPPs have reported to have low gene transfection efficiency mainly due to the fact that DNA is larger than other biomolecules. On the other hand, the conventional linear CPPs are unstable for constructing the DNA complexes with it. Thus, here we designed a branched CPP using disulfide bridges based on the linear TAT peptide, to enhance the gene delivery efficiency in a better way...
2016: Biomaterials Research
https://www.readbyqxmd.com/read/27606073/effect-of-molecular-weight-of-hyaluronic-acid-ha-on-viscoelasticity-and-particle-texturing-feel-of-ha-dermal-biphasic-fillers
#20
Cheolbyong Chun, Deuk Yong Lee, Jin-Tae Kim, Mi-Kyung Kwon, Young-Zu Kim, Seok-Soon Kim
BACKGROUND: Hyaluronic acid (HA) dermal biphasic fillers are synthesized for their efficacy in correcting aesthetic defects such as wrinkles, scars and facial contouring defects. The fillers consist of crosslinked HA microspheres suspended in a noncrosslinked HA. To extend the duration of HAs within the dermis and obtain the particle texturing feel, HAs are crosslinked to obtain the suitable mechanical properties. RESULTS: Hyaluronic acid (HA) dermal biphasic fillers are prepared by mixing the crosslinked HA microspheres and the noncrosslinked HAs...
2016: Biomaterials Research
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