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Biomaterials Research

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https://www.readbyqxmd.com/read/27895934/liposomal-delivery-systems-for-intestinal-lymphatic-drug-transport
#1
REVIEW
Hyeji Ahn, Ji-Ho Park
Intestinal lymphatic drug delivery has been widely studied because drugs can bypass the first-pass metabolism in the liver via the lymphatic route, which increases oral bioavailability. Various lipid-based nanoparticles have been used to deliver hydrophobic drugs to the lymphatic pathway. This review focuses on the liposomal delivery systems used for intestinal lymphatic drug transport. Liposomal formulations have attracted particular attention because they can stimulate the production of chylomicrons and the incorporated drugs readily associate with enterocyte-derived chylomicrons, enhancing lymphatic drug transport...
2016: Biomaterials Research
https://www.readbyqxmd.com/read/27872752/in-vitro-toxicity-study-of-poly-alkylphenol-as-vulcanizing-agent
#2
Joon Woo Chon, Ji Yun Lee, Yoon Ju Song, Jin Hwan Kim, Dong June Chung
In this study, cytotoxicity of various novel poly(alkylpehnol) derivatives which, one of constituent for vulcanizing agent, could be adjusted in medical elastic rubber applications were investigated under various conditions of cytotoxicity test. By MTT-assay which according to ISO 10993-5 regulation, we could figure out cell viability of mouse fibroblast in various sample conditions. Furthermore, by Live & Dead Cell assay, we could get colorimetric cell viability via fluorescence images.
2016: Biomaterials Research
https://www.readbyqxmd.com/read/27826455/mg-63-cells-proliferation-following-various-types-of-mechanical-stimulation-on-cells-by-auxetic-hybrid-scaffolds
#3
Hong Jin Choi, Jun Jae Lee, Jung Bok Lee, Hak-Joon Sung, Jung-Woog Shin, Ji Won Shin, Yanru Wu, Jeong Koo Kim
BACKGROUND: Mechanical properties and cyto-compatibility of a composite scaffold which possessed negative (-) Poisson's ratio (NPR) was investigated for effective load transfer from auxetic scaffold to cell. METHODS: Organic/inorganic composite scaffolds were prepared by mixing hydroxyapatite (HA) to poly(lactide-co-glycolide) (PLGA). To induce NPR in composite scaffold, 3-directional volumetric compression was applied during the scaffold fabrication at adequate temperature(60°C)...
2016: Biomaterials Research
https://www.readbyqxmd.com/read/27807476/lipid-based-surface-engineering-of-plga-nanoparticles-for-drug-and-gene-delivery-applications
#4
REVIEW
Rajendran Jc Bose, Soo-Hong Lee, Hansoo Park
The use of poly(lactic-co-glycolic acid) (PLGA)-based nanocarriers presents several major challenges, including their synthetic hydrophobic surface, low transfection efficiency, short circulation half-life, and nonspecific tissue distribution. Numerous engineering strategies have been employed to overcome these problems, with lipid-based surface functionalization of PLGA nanoparticles (NPs) showing promising results in the development of PLGA-based clinical nanomedicines. Surface engineering with different lipids enhances the target specificity of the carrier and improves its physicochemical properties as well as NP-cell associations, such as cellular membrane permeability, immune responses, and long circulation half-life in vivo...
2016: Biomaterials Research
https://www.readbyqxmd.com/read/27807475/mg-63-osteoblast-like-cell-proliferation-on-auxetic-plga-scaffold-with-mechanical-stimulation-for-bone-tissue-regeneration
#5
Hong Jin Choi, Jun Jae Lee, Yeong Jun Park, Jung-Woog Shin, Hak-Joon Sung, Ji Won Shin, Yanru Wu, Jeong Koo Kim
BACKGROUND: Auxetic scaffolds (experimental) was fabricated by using poly(D, L-lactic-co-glycolic acid), 50:50, (PLGA) for effective bone cell proliferation with mechanical stimulation. METHODS: Negative Poisson's ratio in scaffold, 3-directional volumetric compression was applied during the scaffold fabrication at adequate temperature (60 °C). The pore size of scaffold ranged between 355 and 400 μm. RESULTS: The porous morphology of the prepared auxetic scaffolds had shown partially concave and dent shapes in SEM image as expected...
2016: Biomaterials Research
https://www.readbyqxmd.com/read/27713832/a-comparative-study-of-enzyme-initiators-for-crosslinking-phenol-functionalized-hydrogels-for-cell-encapsulation
#6
Justine J Roberts, Pratibha Naudiyal, Khoon S Lim, Laura A Poole-Warren, Penny J Martens
BACKGROUND: Dityrosine crosslinking in proteins is a bioinspired method of forming hydrogels. This study compares oxidative enzyme initiators for their relative crosslinking efficiency and cytocompatibility using the same phenol group and the same material platform. Four common enzyme and enzyme-like oxidative initiators were probed for resulting material properties and cell viability post-encapsulation. RESULTS: All four initiators can be used to form phenol-crosslinked hydrogels, however gelation rates are dependent on enzyme type, concentration, and the oxidant...
2016: Biomaterials Research
https://www.readbyqxmd.com/read/27708859/polypyrrole-incorporated-conductive-hyaluronic-acid-hydrogels
#7
Jongcheol Yang, Goeun Choe, Sumi Yang, Hyerim Jo, Jae Young Lee
BACKGROUND: Hydrogels that possess hydrophilic and soft characteristics have been widely used in various biomedical applications, such as tissue engineering scaffolds and drug delivery. Conventional hydrogels are not electrically conductive and thus their electrical communication with biological systems is limited. METHOD: To create electrically conductive hydrogels, we fabricated composite hydrogels of hyaluronic acid and polypyrrole. In particular, we synthesized and used pyrrole-hyaluronic acid-conjugates and further chemically polymerized polypyrrole with the conjugates for the production of conductive hydrogels that can display suitable mechanical and structural properties...
2016: Biomaterials Research
https://www.readbyqxmd.com/read/27606074/a-branched-tat-cell-penetrating-peptide-as-a-novel-delivery-carrier-for-the-efficient-gene-transfection
#8
Chanuk Jeong, Jisang Yoo, DaeYong Lee, Yeu-Chun Kim
BACKGROUND: Cell penetrating peptides (CPPs) as one class of non-viral vectors, have been widely explored as a delivery tool due to their cell-penetrating capability with low cytotoxicity. However, CPPs have reported to have low gene transfection efficiency mainly due to the fact that DNA is larger than other biomolecules. On the other hand, the conventional linear CPPs are unstable for constructing the DNA complexes with it. Thus, here we designed a branched CPP using disulfide bridges based on the linear TAT peptide, to enhance the gene delivery efficiency in a better way...
2016: Biomaterials Research
https://www.readbyqxmd.com/read/27606073/effect-of-molecular-weight-of-hyaluronic-acid-ha-on-viscoelasticity-and-particle-texturing-feel-of-ha-dermal-biphasic-fillers
#9
Cheolbyong Chun, Deuk Yong Lee, Jin-Tae Kim, Mi-Kyung Kwon, Young-Zu Kim, Seok-Soon Kim
BACKGROUND: Hyaluronic acid (HA) dermal biphasic fillers are synthesized for their efficacy in correcting aesthetic defects such as wrinkles, scars and facial contouring defects. The fillers consist of crosslinked HA microspheres suspended in a noncrosslinked HA. To extend the duration of HAs within the dermis and obtain the particle texturing feel, HAs are crosslinked to obtain the suitable mechanical properties. RESULTS: Hyaluronic acid (HA) dermal biphasic fillers are prepared by mixing the crosslinked HA microspheres and the noncrosslinked HAs...
2016: Biomaterials Research
https://www.readbyqxmd.com/read/27595009/erratum-to-direct-photo-patterning-on-anthracene-containing-polymer-for-guiding-stem-cell-adhesion
#10
Jungmok You, June Seok Heo, Hyun Ok Kim, Eunkyoung Kim
[This corrects the article DOI: 10.1186/s40824-016-0072-4.].
2016: Biomaterials Research
https://www.readbyqxmd.com/read/27583168/solid-organ-fabrication-comparison-of-decellularization-to-3d-bioprinting
#11
REVIEW
Jangwook P Jung, Didarul B Bhuiyan, Brenda M Ogle
Solid organ fabrication is an ultimate goal of Regenerative Medicine. Since the introduction of Tissue Engineering in 1993, functional biomaterials, stem cells, tunable microenvironments, and high-resolution imaging technologies have significantly advanced efforts to regenerate in vitro culture or tissue platforms. Relatively simple flat or tubular organs are already in (pre)clinical trials and a few commercial products are in market. The road to more complex, high demand, solid organs including heart, kidney and lung will require substantive technical advancement...
2016: Biomaterials Research
https://www.readbyqxmd.com/read/27499887/superior-absorption-and-retention-properties-of-foam-film-silver-dressing-versus-other-commercially-available-silver-dressing
#12
Seung Moon Lee, Il Kyu Park, Yong Soo Kim, Hyun Jung Kim, Hanlim Moon, Stefan Mueller, Harsha Arumugam, Young-Il Jeong
BACKGROUND: The aim of this study is to investigate the physicochemical and structural properties of Medifoam®Silver and to compare with other commercially available silver-containing polyurethane (PU) foam dressing in vitro. METHODS: Surface and cross-section of four polyurethane foam dressings were assessed with field-emission scanning electron microscope. Thickness, density, tensile strength, elongation, absorption rate, absorption/retention capacity and water-vapor transmission (WVT) were measured to compare physical properties of various dressing materials...
2016: Biomaterials Research
https://www.readbyqxmd.com/read/27499886/umbilical-cord-mesenchymal-stem-cells-derived-extracellular-vesicles-can-safely-ameliorate-the-progression-of-chronic-kidney-diseases
#13
Wael Nassar, Mervat El-Ansary, Dina Sabry, Mostafa A Mostafa, Tarek Fayad, Esam Kotb, Mahmoud Temraz, Abdel-Naser Saad, Wael Essa, Heba Adel
BACKGROUND: Bio-products from stem/progenitor cells, such as extracellular vesicles, are likely a new promising approach for reprogramming resident cells in both acute and chronic kidney disease. Forty CKD patients stage III and IV (eGFR 15-60 mg/ml) have been divided into two groups; twenty patients as treatment group "A" and twenty patients as a matching placebo group "B". Two doses of MSC-derived extracellular vesicles had been administered to patients of group "A". Blood urea, serum creatinine, urinary albumin creatinine ratio (UACR) and estimated glomerular filtration rate (eGFR) have been used to assess kidney functions and TNF-α, TGF-β1 and IL-10 have been used to assess the amelioration of the inflammatory immune activity...
2016: Biomaterials Research
https://www.readbyqxmd.com/read/27489725/direct-photo-patterning-on-anthracene-containing-polymer-for-guiding-stem-cell-adhesion
#14
Jungmok You, June Seok Heo, Hyun Ok Kim, Eunkyoumg Kim
BACKGROUND: Various micropatterned surfaces capable of guiding the selective adhesion of biomolecules such as proteins and cells are of great interests in biosensor, diagnostics, drug screening, and tissue engineering. In this study, we described a simple photo-patterning method to prepare micro-patterned films for stem cell patterning using anthracene containing polymers (PMAn). This micro patterned polymer film was prepared by the facile photo-reaction of anthracene units in polymer backbone structure...
2016: Biomaterials Research
https://www.readbyqxmd.com/read/27489724/study-on-chemotaxis-and-chemokinesis-of-bone-marrow-derived-mesenchymal-stem-cells-in-hydrogel-based-3d-microfluidic-devices
#15
Dayoung Yoon, Hyerim Kim, Eojin Lee, Min Hee Park, Seok Chung, Hojeong Jeon, Cheol-Hee Ahn, Kangwon Lee
BACKGROUND: Controlling the fate of mesenchymal stems cells (MSCs) including proliferation, migration and differentiation has recently been studied by many researchers in the tissue engineering field. Especially, recruitment of stem cells to injury sites is the first and crucial step in tissue regeneration. Although significant progress has been made in the chemotactic migration of MSCs, MSC migration in three dimensional environments remains largely unknown. We developed a 3D hydrogel-based microfluidic-device to study the migration behavior of human MSCs in the presence of stromal-cell derived factor-1α (SDF-1α), interleukin 8 (IL-8) and Substance P (SP) which have been utilized as chemoattractant candidates of human mesenchymal stem cells (hMSCs)...
2016: Biomaterials Research
https://www.readbyqxmd.com/read/27468356/collagen-grafted-porous-hdpe-peaa-scaffolds-for-bone-reconstruction
#16
Chang-Shik Kim, Kyung-Hye Jung, Hun Kim, Chan-Bong Kim, Inn-Kyu Kang
After tumor resection, bone reconstruction such as skull base reconstruction using interconnected porous structure is absolutely necessary. In this study, porous scaffolds for bone reconstruction were prepared using heat-pressing and salt-leaching methods. High-density polyethylene (HDPE) and poly(ethylene-co-acrylic acid) (PEAA) were chosen as the polymer composites for producing a porous scaffold of high mechanical strength and having high reactivity with biomaterials such as collagen, respectively. The porous structure was observed through surface images, and its intrusion volume and porosity were measured...
2016: Biomaterials Research
https://www.readbyqxmd.com/read/27418974/cellulose-membrane-as-a-biomaterial-from-hydrolysis-to-depolymerization-with-electron-beam
#17
REVIEW
Mi Young Eo, Huan Fan, Yun Ju Cho, Soung Min Kim, Suk Keun Lee
The cellulose membrane (CM) is a major component of plant cell walls and is both a chemically and mechanically stable synthetic polymer with many applications for use in tissue engineering. However, due to its dissolution difficulty, there are no known physiologically relevant or pharmaceutically clinical applications for this polymer. Thus, research is underway on controlled and adjusted forms of cellulose depolymerization. To advance the study of applying CM for tissue engineering, we have suggested new possibilities for electron beam (E-beam) treatment of CM...
2016: Biomaterials Research
https://www.readbyqxmd.com/read/27386141/antibacterial-potency-of-different-deposition-methods-of-silver-and-copper-containing-diamond-like-carbon-coated-polyethylene
#18
Norbert Harrasser, Sebastian Jüssen, Andreas Obermeir, Ralf Kmeth, Bernd Stritzker, Hans Gollwitzer, Rainer Burgkart
BACKGROUND: Antibacterial coatings of medical devices have been introduced as a promising approach to reduce the risk of infection. In this context, diamond-like carbon coated polyethylene (DLC-PE) can be enriched with bactericidal ions and gain antimicrobial potency. So far, influence of different deposition methods and ions on antimicrobial effects of DLC-PE is unclear. METHODS: We quantitatively determined the antimicrobial potency of different PE surfaces treated with direct ion implantation (II) or plasma immersion ion implantation (PIII) and doped with silver (Ag-DLC-PE) or copper (Cu-DLC-PE)...
2016: Biomaterials Research
https://www.readbyqxmd.com/read/27358746/engineering-approaches-for-regeneration-of-t-lymphopoiesis
#19
REVIEW
Kyung-Ho Roh, Krishnendu Roy
T cells play a central role in immune-homeostasis; specifically in the induction of antigen-specific adaptive immunity against pathogens and mutated self with immunological memory. The thymus is the unique organ where T cells are generated. In this review, first the complex structures and functions of various thymic microcompartments are briefly discussed to identify critical engineering targets for regeneration of thymic functions in vitro and in vivo. Then the biomimetic regenerative engineering approaches are reviewed in three categories: 1) reconstruction of 3-D thymic architecture, 2) cellular engineering, and 3) biomaterials-based artificial presentation of critical biomolecules...
2016: Biomaterials Research
https://www.readbyqxmd.com/read/27354920/multiple-genetically-engineered-humanized-microenvironments-in-a-single-mouse
#20
Jungwoo Lee, Dirk Heckl, Biju Parekkadan
BACKGROUND: Immunodeficient mouse models that accept human cell and tissue grafts can contribute greater knowledge to human stem cell research. In this technical report, we used biomaterial implants seeded with genetically engineered stromal cells to create several unique microenvironments in a single mouse. The scope of study was focused on human CD34 hematopoietic stem/progenitor cell (HSPC) engraftment and differentiation within the engineered microenvironment. RESULTS: A mouse model system was created using subdermal implant sites that overexpressed a specific human cytokines (Vascular Endothelial Growth Factor A (hVEGFa), Stromal Derived Factor 1 Alpha (hSDF1a), or Tumor Necrosis Factor Alpha (hTNFa)) by stromal cells in a three-dimensional biomaterial matrix...
2016: Biomaterials Research
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