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Biomaterials Research

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https://www.readbyqxmd.com/read/29449959/sulfobetaine-methacrylate-hydrogel-coated-anti-fouling-surfaces-for-implantable-biomedical-devices
#1
Se Yeong Lee, Yunki Lee, Phuong Le Thi, Dong Hwan Oh, Ki Dong Park
Background: Zwitterionic molecules have been widely studied as coating materials for preparing anti-fouling surfaces because they possess strong hydration properties that can resist non-specific protein adsorption. Numerous studies on surface modification using zwitterionic molecules have been investigated, such as electrochemically mediated and photoinitiated radical polymerization. However, these methods have some limitations, including multi-step process, difficulties in producing thick and dense layers as well as the requirement of extra facilities...
2018: Biomaterials Research
https://www.readbyqxmd.com/read/29372072/the-market-trend-analysis-and-prospects-of-cancer-molecular-diagnostics-kits
#2
Ju Hwan Seo, Joon Woo Lee, Daemyeong Cho
Background: The molecular diagnostics market can be broadly divided into PCR (rt-PCR, d-PCR), NGS(Next Generation Sequencing), Microarray, FISH(Fluorescent in situ-hybridization) and other categories, based on the diagnostic technique. Also, depending on the disease being diagnosed, the market can also be divided into cancer, infectious diseases, HIV/STDs (herpes, syphilis), and women's health issues such as breast cancer, cervical cancer, ovarian cancer, HPV(human papillomavirus), and vaginitis...
2018: Biomaterials Research
https://www.readbyqxmd.com/read/29308274/enhanced-osteogenic-commitment-of-murine-mesenchymal-stem-cells-on-graphene-oxide-substrate
#3
Jiyong Kim, Hwan D Kim, Jungha Park, Eun-Seo Lee, Eugene Kim, Seunghun S Lee, Jin-Kyung Yang, Yoon-Sik Lee, Nathaniel S Hwang
Background: Tissue engineering is an interdisciplinary field that attempts to restore or regenerate tissues and organs through biomimetic fabrication of scaffolds with specific functionality. In recent years, graphene oxide (GO) is considered as promising biomaterial due to its nontoxicity, high dispersity, and hydrophilic interaction, and these characteristics are key to stimulating the interactions between substrates and cells. Method: In this study, GO substrates were fabricated via chemically immobilizing GO at 1...
2018: Biomaterials Research
https://www.readbyqxmd.com/read/29167746/comparison-of-in-vivo-antibacterial-and-antithrombotic-activities-of-two-types-of-pulmonary-artery-catheters-in-pig
#4
Jung Wook Han, Yeon Soo Shin, Jung Ju Kim, Ho Sung Son
Background: During pulmonary artery catheter (PAC) implantation, inaccurate measurements of hemodynamic parameters due to infection or thrombosis of PAC can result in severe complications. Method: In order to develop a new PAC material, we evaluated the antibacterial and antithrombotic activities of the two types of PAC (Swan Ganz catheter and prototype catheter) in 14 pigs. Results: In the 3-day group, bacterial infection rate was not different between the two types of PAC...
2017: Biomaterials Research
https://www.readbyqxmd.com/read/29152327/proangiogenic-alginate-g-pyrrole-hydrogel-with-decoupled-control-of-mechanical-rigidity-and-electrically-conductivity
#5
Ross J DeVolder, Yongbeom Seo, Hyunjoon Kong
Background: An electrically conductive hydrogel has emerged to regulate cellular secretion activities with electrical stimulation. However, the electrical conductivity of typical hydrogel systems decreases with increasing elastic modulus of the hydrogels because of decreased transport of ions through a polymeric cross-linked mesh. Method: This study hypothesized that the inverse dependency between electrical conductivity and elastic modulus would be made through the cross-linking of conductive monomer-units conjugated to a hydrophilic polymeric backbone...
2017: Biomaterials Research
https://www.readbyqxmd.com/read/29085662/current-strategies-for-treatment-of-intervertebral-disc-degeneration-substitution-and-regeneration-possibilities
#6
REVIEW
Sebastião van Uden, Joana Silva-Correia, Joaquim Miguel Oliveira, Rui Luís Reis
BACKGROUND: Intervertebral disc degeneration has an annual worldwide socioeconomic impact masked as low back pain of over 70 billion euros. This disease has a high prevalence over the working age class, which raises the socioeconomic impact over the years. Acute physical trauma or prolonged intervertebral disc mistreatment triggers a biochemical negative tendency of catabolic-anabolic balance that progress to a chronic degeneration disease. Current biomedical treatments are not only ineffective in the long-run, but can also cause degeneration to spread to adjacent intervertebral discs...
2017: Biomaterials Research
https://www.readbyqxmd.com/read/29075510/lipiodol-nanoemulsions-stabilized-with-polyglycerol-polycaprolactone-block-copolymers-for-theranostic-applications
#7
Trang Huyen Le Kim, Hwiseok Jun, Jin Ho Kim, Keunchil Park, Jee Seon Kim, Yoon Sung Nam
BACKGROUND: Polyglycerol is an attractive hydrophilic building block of amphiphilic copolymers for biomedical and pharmaceutical applications due to its biocompatibility, facile chemical modification, and anti-fouling activity. Herein we introduce theranostic nanoemulsions incorporating anti-cancer therapeutic and contrast agents using linear polyglycerol-poly(ε-caprolactone) diblock copolymers (PG-b-PCL). Lipiodol is used as a core oil that dissolves paclitaxel and serves as a contrast agent for computer tomography (CT)...
2017: Biomaterials Research
https://www.readbyqxmd.com/read/29075509/oligochitosan-stabilized-photoluminescent-gold-nanoconstructs-for-optical-bioimaging
#8
Donghyuck Yoo, Dongwon Lee
BACKGROUND: Gold nanoclusters (AuNCs) are typically composed of several to tens of gold atoms which are stabilized with biomacromolecules such as bovine serum albumin (BSA). Au NCs fluoresces in the visible to near infrared region, in a size-dependent manner. AuNCs solutions have potential as fluorophore in a wide range of biomedical applications such as biodetection, biosensing and bioimaging in vitro and in vivo. However, their stability and harsh condition of preparation limit their biomedical application...
2017: Biomaterials Research
https://www.readbyqxmd.com/read/29075508/effect-of-alginate-concentration-on-chondrogenesis-of-co-cultured-human-adipose-derived-stem-cells-and-nasal-chondrocytes-a-biological-study
#9
Y W Ewa-Choy, B Pingguan-Murphy, N A Abdul-Ghani, J Jahendran, K H Chua
BACKGROUND: The three-dimensional (3D) system is one of the important factors to engineer a biocompatible and functional scaffold for the applications of cell-based therapies for cartilage repair. The 3D alginate hydrogels system has previously been shown to potentially promote chondrogenesis. The chondrocytic differentiation of co-cultured adipose-derived stem cells (ADSCs) and nasal chondrocytes (NCs) within alginate constructs are hypothesized to be influenced by concentration of alginate hydrogel...
2017: Biomaterials Research
https://www.readbyqxmd.com/read/29046823/functionalization-of-ti-40nb-implant-material-with-strontium-by-reactive-sputtering
#10
Markus Göttlicher, Marcus Rohnke, Yannik Moryson, Jürgen Thomas, Joachim Sann, Anja Lode, Matthias Schumacher, Romy Schmidt, Stefan Pilz, Annett Gebert, Thomas Gemming, Jürgen Janek
BACKGROUND: Surface functionalization of orthopedic implants with pharmaceutically active agents is a modern approach to enhance osseointegration in systemically altered bone. A local release of strontium, a verified bone building therapeutic agent, at the fracture site would diminish side effects, which could occur otherwise by oral administration. Strontium surface functionalization of specially designed titanium-niobium (Ti-40Nb) implant alloy would provide an advanced implant system that is mechanically adapted to altered bone with the ability to stimulate bone formation...
2017: Biomaterials Research
https://www.readbyqxmd.com/read/29046822/polyion-complex-micelle-formed-from-tetraphenylethene-containing-block-copolymer
#11
Seong Min Lee, Woo-Dong Jang
BACKGROUND: Polymeric micelles attract great attention in drug delivery and therapeutics. Various types of block copolymers have been designed for the application in biomedical fields. If we can introduce additional functional groups to the block copolymers, we can achieve advanced applications. In this regards, we tried to introduce aggregation induced emission enhancement (AIE) unit in the block copolymer. METHODS: The formation of polyion complex micelle was confirmed by dynamic light scattering and transmission electron microscopy...
2017: Biomaterials Research
https://www.readbyqxmd.com/read/29046821/advances-in-medical-adhesives-inspired-by-aquatic-organisms-adhesion
#12
REVIEW
Kyu Ha Park, Keum-Yong Seong, Seung Yun Yang, Sungbaek Seo
In biomedicine, adhesives for hard and soft tissues are crucial for various clinical purposes. However, compared with that under dry conditions, adhesion performance in the presence of water or moisture is dramatically reduced. In this review, representative types of medical adhesives and the challenging aspects of wet adhesion are introduced. The adhesion mechanisms of marine mussels, sandcastle worms, and endoparasitic worms are described, and stemming from the insights gained, designs based on the chemistry of molecules like catechol and on coacervation and mechanical interlocking platforms are introduced in the viewpoint of translating these natural adhesion mechanisms into synthetic approaches...
2017: Biomaterials Research
https://www.readbyqxmd.com/read/29046820/bioimaging-of-botulinum-toxin-and-hyaluronate-hydrogels-using-zwitterionic-near-infrared-fluorophores
#13
Ki Su Kim, Yun Seop Kim, Kai Bao, Hideyuki Wada, Hak Soo Choi, Sei Kwang Hahn
BACKGROUND: The injection of botulinum toxin (BTX) to reduce facial wrinkles is one of the most frequently performed plastic surgery procedures. The biocompatible hydrogels are injected with BTX for effective tissue augmentation. However, it is difficult to determine the interval of injection for effective tissue augmentation. METHOD: BTX and hyaluronate (HA) hydrogels were labeled with zwitterionic (ZW) near-infrared (NIR) fluorophores and visualized for 3 weeks after injection to BALB/c nude mice...
2017: Biomaterials Research
https://www.readbyqxmd.com/read/28702219/modification-and-optimization-of-electrospun-gelatin-sheets-by-electron-beam-irradiation-for-soft-tissue-engineering
#14
Jae Baek Lee, Young-Gwang Ko, Donghwan Cho, Won Ho Park, Oh Hyeong Kwon
BACKGROUND: Crosslinked gelatin nanofibers are one of the widely used scaffolds for soft tissue engineering. However, modifying the biodegradation rate of chemically crosslinked gelatin is necessary to facilitate cell migration and tissue regeneration. Here, we investigated the optimal electron beam (e-beam) irradiation doses with biodegradation behavior on changes in the molecular weight, morphology, pore structure, and cell proliferation profiles of electrospun nanofibrous gelatin sheets...
2017: Biomaterials Research
https://www.readbyqxmd.com/read/28652927/anticancer-activity-of-drug-loaded-calcium-phosphate-nanocomposites-against-human-osteosarcoma
#15
Kyoung Dan Son, Young-Jin Kim
BACKGROUND: Calcium phosphate (CaP) based nanoparticles are considered to be ideal drug carriers for delivery of anticancer drugs because of their excellent biocompatibility and pH responsiveness. However, CaP nanoparticles have the problems of limited drug load capacity, initial burst release, and short-term release. Thus, we prepared the CaP nanocomposites containing anticancer drug such as caffeic acid (CA-NP), chlorogenic acid (CG-NP), or cisplatin (CP-NP) in the presence of alginate as a polymer template to control the release rate of drugs...
2017: Biomaterials Research
https://www.readbyqxmd.com/read/28652926/silk-fibroin-hydroxyapatite-composite-hydrogel-induced-by-gamma-ray-irradiation-for-bone-tissue-engineering
#16
Min Hee Kim, Beom Su Kim, Jun Lee, Donghwan Cho, Oh Hyeong Kwon, Won Ho Park
BACKGROUND: In this study, silk fibroin (SF) composite hydrogels containing hydroxyapatite (HAP) nanoparticles (NPs) for bone tissue engineering were fabricated using gamma-ray (γ-ray) irradiation treatment. During the irradiation, the HAP dispersed SF solution was changed to the chemically crosslinked SF hydrogel. METHODS: Distribution of HAP NPs in the SF hydrogel was examined by SEM imagery and energy dispersive X-ray spectrophotometry, and the crystalline structure of SF composite hydrogels was also confirmed by X-ray diffractometry...
2017: Biomaterials Research
https://www.readbyqxmd.com/read/28620549/lamination-of-microfibrous-plga-fabric-by-electrospinning-a-layer-of-collagen-hydroxyapatite-composite-nanofibers-for-bone-tissue-engineering
#17
Gi-Wan Kwon, Kailash Chandra Gupta, Kyung-Hye Jung, Inn-Kyu Kang
BACKGROUND: To mimic the muscle inspired cells adhesion through proteins secretion, the lamination of collagen-hydroxyapatite nanorod (nHA) composite nanofibers has been carried out successfully on polydopamine (PDA)-coated microfibrous polylactide-co-glycolide (PLGA) fabrics. The lamination of collagen-hydroxyapatite composite nanofibers on polydopamine-coated microfibrous PLGA fabrics was carried through electrospinning the solution of collagen containing L-glutamic acid-grafted hydroxyapatite nanorods (nHA-GA) at a flow rate of 1...
2017: Biomaterials Research
https://www.readbyqxmd.com/read/28616254/in-vitro-ion-adsorption-and-cytocompatibility-of-dicalcium-phosphate-ceramics
#18
Martha Schamel, Jake E Barralet, Jürgen Groll, Uwe Gbureck
BACKGROUND: In vitro cell testing of degradable bioceramics such as brushite or monetite is often challenging due to the ion release into or adsorption from the culture medium. These ionic changes are then mostly responsible for cell proliferation and activity, which prohibits the investigation of effects originating from surface topography or further material modifications. METHODS: Here, we aimed to solve this problem by developing a pre-conditioning regime following the repeated immersion of brushite and monetite samples in various Ca(2+), Mg(2+) and PO4(3-) containing electrolytes, followed by studying ion adsorption / release as well as changes in phase composition and in vitro cytocompatibility with MG63 cells...
2017: Biomaterials Research
https://www.readbyqxmd.com/read/28593053/natural-graft-tissues-and-synthetic-biomaterials-for-periodontal-and-alveolar-bone-reconstructive-applications-a-review
#19
REVIEW
Zeeshan Sheikh, Nader Hamdan, Yuichi Ikeda, Marc Grynpas, Bernhard Ganss, Michael Glogauer
Periodontal disease is categorized by the destruction of periodontal tissues. Over the years, there have been several clinical techniques and material options that been investigated for periodontal defect repair/regeneration. The development of improved biomaterials for periodontal tissue engineering has significantly improved the available treatment options and their clinical results. Bone replacement graft materials, barrier membranes, various growth factors and combination of these have been used. The available bone tissue replacement materials commonly used include autografts, allografts, xenografts and alloplasts...
2017: Biomaterials Research
https://www.readbyqxmd.com/read/28529764/in-vivo-analysis-of-covering-materials-composed-of-biodegradable-polymers-enriched-with-flax-fibers
#20
Tomasz Gredes, Sandra Schönitz, Tomasz Gedrange, Lukas Stepien, Karol Kozak, Christiane Kunert-Keil
BACKGROUND: The objective of this study was to investigate the in vivo effect of bioactive composites with poly(lactic acid) (PLA) or polycaprolactone (PCL) as the matrix, reinforced with bioplastic flax fibers, on the surrounding muscle tissue. METHODS: Materials of pure PLA and PCL and their composites with flax fibers from genetically modified plants producing poly-3-hydroxybutyrate (PLA-transgen, PCL-transgen) and unmodified plants (PLA-wt, PCL-wt) were placed subcutaneous on the M...
2017: Biomaterials Research
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