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Journal of Pathology and Translational Medicine

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https://www.readbyqxmd.com/read/29166764/merkel-cell-carcinoma-metastatic-to-pleural-fluid-a-case-report
#1
Ye-Young Rhee, Soo Hee Kim, Eun Kyung Kim, Se Hoon Kim
Merkel cell carcinoma (MCC) is a rare aggressive neuroendocrine carcinoma of the skin that shows locoregional and distant metastasis. Metastasis of MCC to body cavity effusion is extremely rare; only three cases had been reported so far. Metastatic MCC in effusion cytology shows small blue round cells with fine stippled chromatin like other small blue round cell tumors such as small cell lung carcinoma or lymphoma. The diagnosis of metastatic MCC could give patients good chances to get recently advanced therapeutic options...
November 23, 2017: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/29166763/an-extremely-rare-cause-of-back-and-hip-pain-due-to-the-metastasis-of-late-recurrent-myxopapillary-ependymoma-to-the-inguinal-lymph-node
#2
Suheyla Ekemen, Ozlem Yapicier, Hatice Deniz Boler, Umit Ince
No abstract text is available yet for this article.
November 23, 2017: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/29121459/extramural-perineural-invasion-in-pt3-and-pt4-gastric-carcinomas
#3
Alejandro España-Ferrufino, Leonardo S Lino-Silva, Rosa A Salcedo-Hernández
Background: Perineural invasion (PNI) is widely studied in malignant tumors, and its prognostic significance is well demonstrated. Most studies have focused on evaluating the mural PNI (mPNI); however, extramural PNI (ePNI) may influence the prognosis in gastric cancer. We evaluated the prognostic value of ePNI compared with mPNI in gastric cancer in this observational comparative cross-sectional study. Materials and Methods: Seventy-three pT3 and pT4 gastric carcinomas with PNI were evaluated...
November 9, 2017: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/29069886/liquid-based-cytology-of-the-cerebrospinal-fluid-in-a-case-of-cryptococcal-meningitis
#4
Jiwoon Choi, Se Hoon Kim
Cryptococcus neoformans is the most common microorganism found in cerebrospinal fluid (CSF) cytology and causes life-threatening infections in immunocompromised hosts. Although its cytomorphologic features in conventional smear cytology have been well described, those in liquid-based cytology have rarely been. A 73-year-old woman with diffuse large B-cell lymphoma presented with mental confusion and a spiking fever. To rule out infectious conditions, CSF examination was performed. A cytology slide that was prepared using the ThinPrep method showed numerous spherical yeast-form organisms with diameters of 4-11 μm and thick capsules...
October 26, 2017: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/29056035/the-smad4-pten-expression-pattern-predicts-clinical-outcomes-in-colorectal-adenocarcinoma
#5
Yumin Chung, Young Chan Wi, Yeseul Kim, Seong Sik Bang, Jung-Ho Yang, Kiseok Jang, Kyueng-Whan Min, Seung Sam Paik
Background: Smad4 and PTEN are prognostic indicators for various tumor types. Smad4 regulates tumor suppression, whereas PTEN inhibits cell proliferation. We analyzed and compared the performance of Smad4 and PTEN for predicting the prognosis of patients with colorectal adenocarcinoma. Materials and Methods: Combined expression patterns based on Smad4+/- and PTEN+/- statuses were evaluated by immunostaining using a tissue microarray with samples from patients with colorectal adenocarcinoma...
October 23, 2017: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/29046514/protein-phosphatase-magnesium-dependent-1%C3%AE-ppm1d-expression-as-a-prognostic-marker-in-adult-supratentorial-diffuse-astrocytic-and-oligodenroglial-tumors
#6
Hui Jeong Jeong, Chang Gok Woo, Bora Lee, Shin Kwang Khang, Soo Jeong Nam, Jene Choi
Background: Protein phosphatase magnesium-dependent 1δ (PPM1D) is a p53-induced serine/threonine phosphatase, which is overexpressed in various human cancers. A recent study reported that the mutation in the PPM1D gene is associated with poor prognosis in brainstem gliomas. In this study, we evaluate the utility of PPM1D as a prognostic biomarker of adult supratentorial diffuse astrocytic and oligodenroglial tumors. Materials and Methods: To investigate PPM1D protein expression, mRNA expression, and copy number changes, immunohistochemistry, RNAscope in situ hybridization, and fluorescence in situ hybridization in 84 adult supratentorial diffuse gliomas were performed, respectively...
October 18, 2017: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/28994275/combined-adenosquamous-and-large-cell-neuroendocrine-carcinoma-of-the-gallbladder
#7
Jiyoon Jung, Yang-Seok Chae, Chul Hwan Kim, Youngseok Lee, Jeong Hyeon Lee, Dong-Sik Kim, Young-Dong Yu, Joo Young Kim
Large cell neuroendocrine carcinoma (LCNEC) of the gallbladder is extremely rare and usually combined with other type of malignancy, mostly adenocarcinoma. We report an unusual case of combined adenosquamous carcinoma and LCNEC of the gallbladder in a 54-year-old woman. A radical cholecystectomy specimen revealed a 4.3×4.0 cm polypoid mass in the fundus with infiltration of adjacent liver parenchyma. Microscopically, the tumor consisted of two distinct components. Adenosquamous carcinoma was predominant and abrupt transition from adenocarcinoma to squamous cell carcinoma was observed...
October 5, 2017: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/28994273/secretory-carcinoma-arising-in-a-fibroadenoma-a-brief-case-report
#8
Sharon Lim, Min Keun Shim, Eun Yoon Cho, Soo Youn Cho
No abstract text is available yet for this article.
October 4, 2017: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/28994272/programmed-death-ligand-1-expression-and-its-correlation-with-lymph-node-metastasis-in-papillary-thyroid-carcinoma
#9
Hyo Jung An, Gyung Hyuck Ko, Jeong-Hee Lee, Jong Sil Lee, Dong Chul Kim, Jung Wook Yang, Min Hye Kim, Jin Pyeong Kim, Eun Jung Jung, Dae Hyun Song
Background: The immunotherapeutic role of programmed death-ligand 1 (PD-L1) in life expectancy in many cancers has been highlighted. However, data regarding PD-L1 expression in papillary thyroid carcinoma (PTC) are limited. In this study, we describe the PD-L1 and programmed cell death protein 1 (PD-1) expressions in PTC and analyze their correlation with lymph node (LN) metastasis. Materials and Methods: Clinicopathological data were obtained from 116 patients with PTC who were treated in Gyeongsang National University Hospital, Jinju, Korea in 2009...
October 3, 2017: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/28958143/reclassification-of-mixed-oligoastrocytic-tumors-using-a-genetically-integrated-diagnostic-approach
#10
Seong-Ik Kim, Yujin Lee, Jae-Kyung Won, Chul-Kee Park, Seung Hong Choi, Sung-Hye Park
Background: Mixed gliomas, such as oligoastrocytomas (OA), anaplastic oligoastrocytomas, and glioblastomas with an oligodendroglial component (GBMO) are defined as tumors composed of a mixture of two distinct neoplastic cell types, astrocytic and oligodendroglial. Recently, mutations ATRX and TP53, and codeletion of 1p/19q are shown to be genetic hallmarks of astrocytic and oligodendroglial tumors, respectively. Subsequent molecular analyses of mixed gliomas preferred the reclassification to either oligodendroglioma or astrocytoma...
September 29, 2017: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/29161789/current-status-of-thyroid-fine-needle-aspiration-practice-in-thailand
#11
REVIEW
Somboon Keelawat, Samreung Rangdaeng, Supinda Koonmee, Tikamporn Jitpasutham, Andrey Bychkov
Thyroid carcinoma is one of the leading malignancies in Thailand increasingly prevalent in the female population. Fine-needle aspiration (FNA) cytology is a widely used diagnostic tool for evaluation of thyroid nodules and thyroid cancer. Thyroid FNA is a routine procedure universally performed in Thai hospitals by a variety of clinical specialists. Manual guidance is the first-line choice complemented by ultrasound assistance in selected cases. Despite national guidelines recommendations, the diagnostic criteria and terminology of the Bethesda System for Reporting Thyroid Cytopathology (TBSRTC) was slowly adopted in the local settings...
November 2017: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/29161788/aggressive-supratentorial-ependymoma-rela-fusion-positive-with-extracranial-metastasis-a-case-report
#12
Seong-Ik Kim, Yoojin Lee, Seung Ki Kim, Hyoung Jin Kang, Sung-Hye Park
Ependymoma is the third most common pediatric primary brain tumor. Ependymomas are categorized according to their locations and genetic abnormalities, and these two parameters are important prognostic factors for patient outcome. For supratentorial (ST) ependymomas, RELA fusion-positive ependymomas show a more aggressive behavior than YAP1 fusion-positive ependymomas. Extracranial metastases of intra-axial neuroepithelial tumors are extremely rare. In this paper, we report a case of aggressive anaplastic ependymoma arising in the right frontoparietal lobe, which had genetically 1q25 gain, CDKN2A homozygous deletion, and L1CAM overexpression...
November 2017: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/29073758/the-use-of-fine-needle-aspiration-fna-cytology-in-patients-with-thyroid-nodules-in-asia-a-brief-overview-of-studies-from-the-working-group-of-asian-thyroid-fna-cytology
#13
REVIEW
Chan Kwon Jung, SoonWon Hong, Andrey Bychkov, Kennichi Kakudo
Ultrasound-guided fine-needle aspiration (FNA) cytology is the most widely used screening and diagnostic method for thyroid nodules. Although Western guidelines for managing thyroid nodules and the Bethesda System for Reporting Thyroid Cytopathology are widely available throughout Asia, the clinical practices in Asia vary from those of Western countries. Accordingly, the Working Group of Asian Thyroid FNA Cytology encouraged group members to publish their works jointly with the same topic. The articles in this special issue focused on the history of thyroid FNA, FNA performers and interpreters, training programs of cytopathologists and cytotechnicians, staining methods, the reporting system of thyroid FNA, quality assurance programs, ancillary testing, and literature review of their own country's products...
November 2017: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/29046516/current-practices-of-thyroid-fine-needle-aspiration-in-asia-a-missing-voice
#14
Andrey Bychkov, Kennichi Kakudo, SoonWon Hong
No abstract text is available yet for this article.
November 2017: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/29046515/thyroid-fine-needle-aspiration-in-taiwan-the-history-and-current-practice
#15
REVIEW
Jen-Fan Hang, Chih-Yi Hsu, Chiung-Ru Lai
In Taiwan, thyroid cancer is the most common endocrine gland malignancy and the incidence of thyroid cancer has increased four-fold in the past two decades. Fine-needle aspiration is an accurate and cost-effective method of evaluating thyroid nodules and has been the gold-standard diagnostic tool for thyroid tumors in Taiwan since the 1980s. This article reviews the history, current practice, reporting systems, training, and quality assurance for thyroid fine-needle aspiration cytology in Taiwan.
November 2017: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/29046513/history-and-practice-of-thyroid-fine-needle-aspiration-in-china-based-on-retrospective-study-of-the-practice-in-shandong-university-qilu-hospital
#16
REVIEW
Zhiyan Liu, Dongge Liu, Bowen Ma, Xiaofang Zhang, Peng Su, Li Chen, Qingdong Zeng
Cytology in China developed from nothing and underwent a long journey from gynecologic cytology to that of all organs, laying a solid foundation for new developments in the 21st century. Thyroid fine-needle aspiration (FNA) was primarily developed in an endocrinology department and then in the clinical laboratory department or pathology department in the 1970-80s. Wrights staining is popular in endocrine and clinical laboratory departments, while hematoxylin and eosin staining is common in pathology. Liquid based cytology is not common in thyroid FNA cytology, while BRAF V600E mutation analysis has been the most popular molecular test...
November 2017: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/29017315/thyroid-cytology-the-japanese-system-and-experience-at-yamashita-thyroid-hospital
#17
REVIEW
Shinya Satoh, Hiroyuki Yamashita, Kennichi Kakudo
In Japan, fine-needle aspiration (FNA) cytology is the most important diagnostic modality for triaging patients with thyroid nodules. A clinician (endocrinologist, endocrine surgeon, or head and neck surgeon) generally performs FNA cytology at the outpatient clinic, and ultrasound (US)-guided FNA is widespread because US is extremely common and most clinicians are familiar with it. Although almost all FNA thyroid samples are examined by certified cytopathologists and pathologists, some clinicians assess cytological specimens themselves...
November 2017: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/29017314/thyroid-fine-needle-aspiration-cytology-practice-in-korea
#18
REVIEW
Yoon Jin Cha, Ju Yeon Pyo, SoonWon Hong, Jae Yeon Seok, Kyung-Ju Kim, Jee-Young Han, Jeong Mo Bae, Hyeong Ju Kwon, Yeejeong Kim, Kyueng-Whan Min, Soonae Oak, Sunhee Chang
We reviewed the current status of thyroid fine-needle aspiration cytology (FNAC) in Korea. Thyroid aspiration biopsy was first introduced in Korea in 1977. Currently, radiologists aspirate the thyroid nodule under the guidance of ultrasonography, and cytologic interpretation is only legally approved when a cytopathologist makes the diagnosis. In 2008, eight thyroid-related societies came together to form the Korean Thyroid Association. The Korean Society for Cytopathology and the endocrine pathology study group of the Korean Society for Pathologists have been updating the cytologic diagnostic guidelines...
November 2017: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/28994276/thyroid-fine-needle-aspiration-practice-in-the-philippines
#19
REVIEW
Agustina D Abelardo
Fine-needle aspiration (FNA) is a well accepted initial approach in the management of thyroid lesions. It has come a long way since its introduction for nearly a century ago. In the Philippines, FNA of the thyroid was first introduced 30 years ago and has been utilized until now as a mainstay in the diagnosis of thyroid malignancy. The procedure is performed by pathologists, endocrinologists, surgeons, and radiologists. Most pathologists report the cytodiagnosis using a combination of the aspiration biopsy cytology method that closely resembles the histopathologic diagnosis of thyroid disorders and the six-tier nomenclature of The Bethesda System for Reporting Thyroid Cytopathology...
November 2017: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/28994274/thyroid-cytology-in-india-contemporary-review-and-meta-analysis
#20
REVIEW
Shipra Agarwal, Deepali Jain
Fine-needle aspiration cytology (FNAC) is a screening test for triaging thyroid nodules, aiding in subsequent clinical management. However, the advantages have been overshadowed by the multiplicity of reporting systems and a wide range of nomenclature used. The Bethesda System for Reporting Thyroid Cytopathology (TBSRTC) was formulated in 2007, to give the world a uniform thyroid cytology reporting system, facilitating easy interpretation by the clinicians. Here, we review the status of thyroid FNAC in India in terms of various reporting systems used including a meta-analysis of the previously published data...
November 2017: Journal of Pathology and Translational Medicine
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