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Journal of Pathology and Translational Medicine

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https://www.readbyqxmd.com/read/28103653/history-of-the-official-journal-published-by-the-korean-society-of-pathologists-from-the-korean-journal-of-pathology-to-the-journal-of-pathology-and-translational-medicine
#1
Se Hoon Kim, Chong Jai Kim, SoonWon Hong
No abstract text is available yet for this article.
January 2017: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/28063419/perivascular-epithelioid-cell-tumors-pecomas-of-the-orbit
#2
Panagiotis Paliogiannis, Giuseppe Palmieri, Francesco Tanda, Antonio Cossu
No abstract text is available yet for this article.
January 2017: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/28013535/human-herpes-virus-8-epstein-barr-virus-copositive-plasmablastic-microlymphoma-arising-in-multicentric-castleman-s-disease-of-an-immunocompetent-patient
#3
Yong-Moon Lee, Jin-Man Kim, Sam-Yong Kim
No abstract text is available yet for this article.
January 2017: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/28013534/kras-mutation-test-in-korean-patients-with-colorectal-carcinomas-a-methodological-comparison-between-sanger-sequencing-and-a-real-time-pcr-based-assay
#4
Sung Hak Lee, Arthur Minwoo Chung, Ahwon Lee, Woo Jin Oh, Yeong Jin Choi, Youn-Soo Lee, Eun Sun Jung
BACKGROUND: Mutations in the KRAS gene have been identified in approximately 50% of colorectal cancers (CRCs). KRAS mutations are well established biomarkers in anti-epidermal growth factor receptor therapy. Therefore, assessment of KRAS mutations is needed in CRC patients to ensure appropriate treatment. METHODS: We compared the analytical performance of the cobas test to Sanger sequencing in 264 CRC cases. In addition, discordant specimens were evaluated by 454 pyrosequencing...
January 2017: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/28013533/evaluation-of-pathologic-complete-response-in-breast-cancer-patients-treated-with-neoadjuvant-chemotherapy-experience-in-a-single-institution-over-a-10-year-period
#5
Misun Choi, Yeon Hee Park, Jin Seok Ahn, Young-Hyuck Im, Seok Jin Nam, Soo Youn Cho, Eun Yoon Cho
BACKGROUND: Pathologic complete response (pCR) after neoadjuvant chemotherapy (NAC) has been associated with favorable clinical outcome in breast cancer patients. However, the possibility that the prognostic significance of pCR differs among various definitions has not been established. METHODS: We retrospectively evaluated the pathologic response after NAC in 353 breast cancer patients and compared the prognoses after applying the following different definitions of pCR: ypT0/is, ypT0, ypT0/is ypN0, and ypT0 ypN0...
January 2017: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/28013532/aurora-kinase-a-is-a-prognostic-marker-in-colorectal-adenocarcinoma
#6
Hyun Min Koh, Bo Geun Jang, Chang Lim Hyun, Young Sill Kim, Jin Won Hyun, Weon Young Chang, Young Hee Maeng
BACKGROUND: Aurora kinase A (AURKA), or STK15/BTAK, is a member of the serine/threonine kinase family and plays important roles in mitosis and chromosome stability. This study investigated the clinical significance of AURKA expression in colorectal cancer patients in Korea. METHODS: AURKA protein expression was evaluated by immunohistochemistry in 151 patients with colorectal adenocarcinoma using tissue microarray blocks. We analyzed the relationship between clinicopathological characteristics and AURKA expression...
January 2017: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/28013531/prognosis-of-hepatocellular-carcinoma-after-liver-transplantation-comparative-analysis-with-partial-hepatectomy
#7
Kyuho Lee, Kyoung-Bun Lee, Nam-Joon Yi, Kyung-Suk Suh, Ja-June Jang
BACKGROUND: Liver transplantation (LT) is the treatment of choice for hepatocellular carcinoma (HCC). The aim of this study was to investigate the recurrence rate of HCC after LT and prognostic factors for recurrence by comparing LT with non-transplanted resection. METHODS: The participants were 338 patients who underwent LT between 1996 and 2012 at Seoul National University Hospital (LT group) and 520 HCC patients who underwent partial hepatectomy between 1995 and 2006 (control group, non-LT group)...
January 2017: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/27989100/pd-l1-expression-and-combined-status-of-pd-l1-pd-1-positive-tumor-infiltrating-mononuclear-cell-density-predict-prognosis-in-glioblastoma-patients
#8
Jiheun Han, Yongkil Hong, Youn Soo Lee
BACKGROUND: Programmed death ligand 1 (PD-L1) in tumor cells is known to promote immune escape of cancer by interacting with programmed cell death 1 (PD-1) in tumor infiltrating immune cells. Immunotherapy targeting these molecules is emerging as a new strategy for the treatment of glioblastoma (GBM). Understanding the relationship between the PD-L1/PD-1 axis and prognosis in GBM patients may be helpful to predict the effects of immunotherapy. METHODS: PD-L1 expression and PD-1-positive tumor infiltrating mononuclear cell (PD-1+tumor infiltrating mononuclear cell [TIMC]) density were evaluated using tissue microarray containing 54 GBM cases by immunohistochemical analysis; the associations with patient clinical outcomes were evaluated...
January 2017: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/27989099/clinicopathologic-significance-of-survivin-expression-in-relation-to-cd133-expression-in-surgically-resected-stage-ii-or-iii-colorectal-cancer
#9
Wanlu Li, Mi-Ra Lee, EunHee Choi, Mee-Yon Cho
BACKGROUND: Cancer stem cells have been investigated as new targets for colorectal cancer (CRC) treatment. We recently reported that CD133(+) colon cancer cells showed chemoresistance to 5-fluorouracil through increased survivin expression and proposed the survivin inhibitor YM155 as an effective therapy for colon cancer in an in vitro study. Here, we investigate the relationship between survivin and CD133 expression in surgically resected CRC to identify whether the results obtained in our in vitro study are applicable to clinical samples...
January 2017: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/27744658/size-of-non-lepidic-invasive-pattern-predicts-recurrence-in-pulmonary-mucinous-adenocarcinoma-morphologic-analysis-of-188-resected-cases-with-reappraisal-of-invasion-criteria
#10
Soohyun Hwang, Joungho Han, Misun Choi, Myung-Ju Ahn, Yong Soo Choi
BACKGROUND: We reviewed a series of 188 resected pulmonary mucinous adenocarcinomas (MAs) to clarify the prognostic significance of lepidic and non-lepidic patterns. METHODS: Non-lepidic patterns were divided into bland, non-distorted acini with uncertain invasiveness (pattern 1), unequivocal invasion into stroma (pattern 2), or invasion into alveolar spaces (pattern 3). RESULTS: The mean proportion of invasive patterns (patterns 2 and 3) was lowest in small (≤ 3 cm) tumors, and gradually increased in intermediate (> 3 cm and ≤ 7 cm) and large (> 7 cm) tumors (8...
January 2017: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/27744656/increased-expression-of-thymosin-%C3%AE-4-is-independently-correlated-with-hypoxia-inducible-factor-1%C3%AE-hif-1%C3%AE-and-worse-clinical-outcome-in-human-colorectal-cancer
#11
Seung Yun Lee, Mee Ja Park, Hye Kyung Lee, Hyun Jin Son, Chang Nam Kim, Joo Heon Kim, Dong Wook Kang
BACKGROUND: Thymosin β4 is a multi-functional hormone-like polypeptide, being involved in cell migration, angiogenesis, and tumor metastasis. This study was undertaken to clarify the clinicopathologic implications of thymosin β4 expression in human colorectal cancers (CRCs). METHODS: We investigated tissue sections from 143 patients with CRC by immunohistochemistry. In addition, we evaluated the expression patterns and the clinico-pathological significance of thymosin β4 expression in association with hypoxia inducible factor-1α (HIF-1α) expression in the CRC series...
January 2017: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/27737528/diagnostic-significance-of-cellular-neuroglial-tissue-in-ovarian-immature-teratoma
#12
Yun Chai, Chang Gok Woo, Joo-Young Kim, Chong Jai Kim, Shin Kwang Khang, Jiyoon Kim, In Ah Park, Eun Na Kim, Kyu-Rae Kim
BACKGROUND: Immature teratoma (IT) is a tumor containing immature neuroectodermal tissue, primarily in the form of neuroepithelial tubules. However, the diagnosis of tumors containing only cellular neuroglial tissue (CNT) without distinct neuroepithelial tubules is often difficult, since the histological characteristics of immature neuroectodermal tissues remain unclear. Here, we examined the significance of CNT and tried to define immature neuroectodermal tissues by comparing the histological features of neuroglial tissues between mature teratoma (MT) and IT...
January 2017: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/27550046/a-rare-case-of-angioleiomyoma-arising-in-the-subglottic-area-to-upper-trachea-of-a-patient-with-underlying-asthma
#13
Yeoun Eun Sung, Chin Kook Rhee, Kyo Young Lee
Angioleiomyoma is a rare disease that is histologically characterized by smooth muscle cells arranged around vascular spaces. Although angioleiomyomas occur rarely in the head and neck region, they can cause various symptoms according the site involved. Here, we present a 44-year-old male patient with a 15-year history of asthma, who presented with recent onset of chest discomfort, globus sensation and throat pain. Medication was not effective in relieving his symptoms, and further evaluation revealed a polypoid ovoid mass, almost obstructing the airway at the border of the larynx and upper trachea on chest computed tomography...
January 2017: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/27498547/adult-intussusception-caused-by-inverted-meckel-s-diverticulum-containing-mesenteric-heterotopic-pancreas-and-smooth-muscle-bundles
#14
Seungkoo Lee, Seong Whi Cho
No abstract text is available yet for this article.
January 2017: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/27498546/a-rare-case-of-recurrent-metastatic-solid-pseudopapillary-neoplasm-of-the-pancreas
#15
Hye Seung Lee, Han Kyeom Kim, Bong Kyung Shin, Jin Hyuk Choi, Yoo Jin Choi, Ha Yeon Kim
A 61-year-old woman visited our hospital for bilateral multiple lung nodules and a mass in her thorax. She had a long history of multiple metastatic recurrences of solid pseudopapillary neoplasm (SPN); 24 years previously, the patient had undergone pylorus-preserving pancreaticoduodenectomy for a 9.9 × 8.6 cm mass in the pancreatic head. The tumor was diagnosed as an SPN. Nine years later, metastatic nodules were found on computed tomography in the patient's liver and peritoneum and were excised. She subsequently underwent an additional eight metastatectomy procedures in diverse organs...
January 2017: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/27809448/immunohistochemistry-for-pathologists-protocols-pitfalls-and-tips
#16
REVIEW
So-Woon Kim, Jin Roh, Chan-Sik Park
Immunohistochemistry (IHC) is an important auxiliary method for pathologists in routine diagnostic work as well as in basic and clinical research including exploration of biomarkers, as IHC allows confirmation of target molecule expressions in the context of microenvironment. Although there has been a considerable progress in automation and standardization of IHC, there are still many things to be considered in proper optimization and appropriate interpretation. In this review, we aim to provide possible pitfalls and useful tips for practicing pathologists and residents in pathology training...
November 2016: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/27780340/cd9-expression-in-colorectal-carcinomas-and-its-prognostic-significance
#17
Kyung-Ju Kim, Hee Jung Kwon, Min Chong Kim, Young Kyung Bae
BACKGROUND: CD9, a member of the tetraspanin superfamily, is a tumor suppressor in many malignancies. The aim of this study was to evaluate the immunohistochemical expression of CD9 in colorectal carcinomas (CRCs) and determine clinicopathological and prognostic significance of its expression. METHODS: The CD9 expression status of 305 CRCs was evaluated using a semi-quantitative scoring system in tumor cells (T-CD9) and immune cells (I-CD9) by classifying the results as high and low expression...
November 2016: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/27744657/pathogenesis-of-focal-segmental-glomerulosclerosis
#18
REVIEW
Beom Jin Lim, Jae Won Yang, Woo Sung Do, Agnes B Fogo
Focal segmental glomerulosclerosis (FSGS) is characterized by focal and segmental obliteration of glomerular capillary tufts with increased matrix. FSGS is classified as collapsing, tip, cellular, perihilar and not otherwise specified variants according to the location and character of the sclerotic lesion. Primary or idiopathic FSGS is considered to be related to podocyte injury, and the pathogenesis of podocyte injury has been actively investigated. Several circulating factors affecting podocyte permeability barrier have been proposed, but not proven to cause FSGS...
November 2016: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/27737529/morphological-and-functional-changes-in-the-thyroid-follicles-of-the-aged-murine-and-humans
#19
Junguee Lee, Shinae Yi, Yea Eun Kang, Hyeon-Woo Kim, Kyong Hye Joung, Hae Joung Sul, Koon Soon Kim, Minho Shong
BACKGROUND: Although both thyroid histology and serum concentrations of hormones are known to change with age, only a few reports exist on the relationship between the age-related structural and functional changes of the thyroid follicles in both mice and humans. Our objectives were to investigate age-related histological changes of the thyroid follicles and to determine whether these morphological changes were associated with the functional activity of the follicles. METHODS: The thyroid glands of mice at 18 weeks and at 6, 15, and 30 months of age were histologically examined, and the serum levels of thyroid hormones were measured in 11-week-old and 20-month-old mice...
November 2016: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/27725621/comparison-of-the-fda-and-asco-cap-criteria-for-her2-immunohistochemistry-in-upper-urinary-tract-urothelial-carcinoma
#20
Gilhyang Kim, Yul Ri Chung, Bohyun Kim, Boram Song, Kyung Chul Moon
BACKGROUND: Human epidermal growth factor receptor 2 (HER2) is one of the known oncogenes in urothelial carcinoma. However, the association between HER2 and the prognosis of upper urinary tract urothelial carcinoma (UUTUC) has not yet been fully clarified. The aim of this study was to evaluate HER2 expression using the United States Food and Drug Administration (FDA) criteria and American Society of Clinical Oncology/College of American Pathologists (ASCO/CAP) criteria and compare their prognostic significance in UUTUC...
November 2016: Journal of Pathology and Translational Medicine
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