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Journal of Pathology and Translational Medicine

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https://www.readbyqxmd.com/read/29747485/sudden-child-death-due-to-thrombotic-giant-coronary-artery-aneurysms-complicated-by-atypical-kawasaki-disease-an-autopsy-case
#1
DongJa Kim, Man-Hoon Han, SangHan Lee
No abstract text is available yet for this article.
May 11, 2018: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/29673240/the-major-role-of-nf-kb-in-the-depth-of-invasion-on-acral-melanoma-by-decreasing-cd8-t-cells
#2
Hermin Aminah Usman, Bethy S Hernowo, Maringan Diapari Lumban Tobing, Reti Hindritiani
Background: The tumor microenvironment including immune surveillance affects malignant melanoma (MM) behavior. Nuclear factor кB (NF-κB) stimulates the transcription of various genes in the nucleus and plays a role in the inflammatory process and in tumorigenesis. CD8+ T cells have cytotoxic properties important in the elimination of tumors. However, inhibitory receptors on the cell surface will bind to programmed death-ligand 1 (PD-L1), causing CD8+ T cells to lose their ability to initiate an immune response...
April 20, 2018: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/29621880/let-archived-paraffin-blocks-be-utilized-for-research-with-waiver-of-informed-consent
#3
Yong-Jin Kim, Jeong Sik Park, Karam Ko, Chang Rok Jeong
Advances in biomedical and genetic research have contributed to more effective public health improvement via bench to bed research and the emergence of personalized medicine. This has certainly showcased the importance of archived human tissues, especially paraffin-embedded blocks in pathology. Currently in Korea, undue legislative regulations of the Bioethics and Safety Act suspend and at times discourage studies from taking place. In this paper, the authors underline the value of paraffin blocks in the era of personalized and translational medicine...
April 5, 2018: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/29621879/recurrent-indeterminate-dendritic-cell-tumor-of-the-skin
#4
Jin Woo Joo, Taek Chung, Yoon Ah Cho, Sang Kyum Kim
Indeterminate dendritic cell tumor (IDCT) is a dendritic cell tumor that displays histologic features similar to those of Langerhans cells. The origin of the indeterminate cells may represent precursors of Langerhans cells or skin dendritic cells. IDCT is extremely rare, and tumor progression and predictive factors are not well known. Here, we report a case of a 61-year-old man who presented with a papule on his back and was finally diagnosed with IDCT based on histology and immunohistochemistry. The tumor recurred months after surgical excision...
April 5, 2018: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/29614546/cytologic-diagnosis-of-noninvasive-follicular-thyroid-neoplasm-with-papillary-like-nuclear-features-and-its-impact-on-the-risk-of-malignancy-in-the-bethesda-system-for-reporting-thyroid-cytopathology-an-institutional-experience
#5
Milim Kim, Joung Eun Kim, Hyun Jeong Kim, Yul Ri Chung, Yoonjin Kwak, So Yeon Park
Background: This study was performed to analyze cytologic diagnosis of noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) and its impact on the risk of malignancy (ROM) in the Bethesda System for Reporting Thyroid Cytopathology (TBSRTC). Materials and Methods: 5549 cases of thyroid fine-needle aspiration cytology (FNAC) diagnosed between 2012 and 2014 were included in this study. Diagnostic categories based on TBSRTC were compared with final surgical diagnoses, and the ROM in each category was calculated both including and excluding NIFTP from the malignant lesions...
April 3, 2018: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/29590747/collagenous-spherulosis-associated-with-lobular-carcinoma-in-situ-of-the-breast-two-case-reports
#6
Ga-Eon Kim, Nah Ihm Kim, Ji Shin Lee, Min Ho Park
Collagenous spherulosis (CS) of the breast is a distinctive disease, and is characterized by myoepithelial and epithelial proliferation of nodules in the eosinophilic or basophilic basement membrane enclosed in spherical spaces. CS is rare, but frequently occurs in association with other benign proliferative lesions of the breast. CS is also associated with lobular carcinoma in situ (LCIS). Here, we report two cases of CS associated with LCIS of the breast. Two patients presented with nodules on ultrasound imaging...
March 29, 2018: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/29590746/utility-of-braf-ve1-immunostaining-as-a-screening-tool-for-colorectal-cancer-harboring-braf-v600e-mutation
#7
Jeong-Hwa Kwon, Byung-Kwan Jeong, Yong Sik Yoon, Chang Sik Yu, Jihun Kim
Background: BRAF mutation has been recognized as an important biomarker of colorectal cancer (CRC) for targeted therapy and prognosis prediction. However, sequencing of every CRC case is not cost-effective. Since an antibody specific for BRAF V600E mutant protein was introduced, we examined the utility of BRAF VE1 immunohistochemistry for evaluating BRAF mutations in CRC. Materials and Methods: Fifty-one BRAF-mutated and age, sex-matched 100 BRAF-wild type CRCs were selected at Asan Medical Center from 2005 to 2015...
March 29, 2018: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/29575851/molecular-screening-of-small-biopsy-samples-using-next-generation-sequencing-in-korean-patients-with-advanced-non-small-cell-lung-cancer-korean-lung-cancer-consortium-klcc-13-01
#8
Bo Mi Ku, Mi Hwa Heo, Joo-Hang Kim, Byoung Chul Cho, Eun Kyung Cho, Young Joo Min, Ki Hyeong Lee, Jong-Mu Sun, Se-Hoon Lee, Jin Seok Ahn, Keunchil Park, Tae Jung Kim, Ho Yun Lee, Hojoong Kim, Kyung-Jong Lee, Myung-Ju Ahn
Background: Non-small cell lung cancer (NSCLC) is a common type of cancer with typically poor prognosis. As individual cancers exhibit unique mutation patterns, identifying and characterizing gene mutations in NSCLC might help predict patient outcomes and guide treatment. The aim of this study was to evaluate the clinical adequacy of molecular testing using next-generation sequencing (NGS) for small biopsy samples and characterize the mutational landscape of Korean patients with advanced NSCLC...
March 26, 2018: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/29554794/myoferlin-expression-and-its-correlation-with-figo-histologic-grading-in-early-stage-endometrioid-carcinoma
#9
Min Hye Kim, Dae Hyun Song, Gyung Hyuck Ko, Jeong Hee Lee, Dong Chul Kim, Jung Wook Yang, Hyang Im Lee, Hyo Jung An, Jong Sil Lee
BACKGROUND: For endometrioid carcinoma patients, International Federation of Gynecologists and Obstetricians (FIGO) histologic grading is very important for identifying the appropriate treatment method. However, the interobserver discrepancy with this three-tiered grading system is a serious potential problem. In this study, we used immunohistochemistry to analyze the relationship between FIGO histologic grading score and myoferlin expression. METHODS: We studied the endometrioid carcinoma tissues of 60 patients from Gyeongsang National University Hospital between January 2002 and December 2009...
March 2018: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/29433159/prognostic-utility-of-histological-growth-patterns-of-colorectal-lung-oligometastasis
#10
Son Jae Yeong, Min Gyoung Pak, Hyoun Wook Lee, Seung Yeon Ha, Mee Sook Roh
BACKGROUND: Patients with resectable colorectal lung oligometastasis (CLOM) demonstrate a heterogeneous oncological outcome. However, the parameters for predicting tumor aggressiveness have not yet been fully investigated in CLOM. This study was performed to determine the prognostic value of histological growth patterns in patients who underwent surgery for CLOM. METHODS: The study included 92 patients who were diagnosed with CLOM among the first resection cases...
March 2018: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/29429327/preoperative-cytologic-diagnosis-of-warthin-like-variant-of-papillary-thyroid-carcinoma
#11
Jisup Kim, Beom Jin Lim, Soon Won Hong, Ju Yeon Pyo
BACKGROUND: Warthin-like variant of papillary thyroid carcinoma (WLV-PTC) is a relatively rare variant of papillary thyroid carcinoma with favorable prognosis. However, preoperative diagnosis using fine-needle aspiration (FNA) specimens is challenging especially with lymphocytic thyroiditis characterized by Hürthle cells and lymphocytic background. To determine a helpful cytological differential point, we compared WLV-PTC FNA findings with conventional papillary thyroid carcinoma with lymphocytic thyroiditis (PTC-LT) and conventional papillary thyroid carcinoma without lymphocytic thyroiditis (PTC) regarding infiltrating inflammatory cells and their distribution...
March 2018: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/29429326/denosumab-treated-giant-cell-tumor-of-the-bone-mimicking-low-grade-central-osteosarcoma
#12
Chang-Che Wu, Pin-Pen Hsieh
No abstract text is available yet for this article.
March 2018: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/29374960/cytological-features-that-differentiate-follicular-neoplasm-from-mimicking-lesions
#13
Kanghee Han, Hwa-Jeong Ha, Joon Seog Kong, Jung-Soon Kim, Jae Kyung Myung, Jae Soo Koh, Sunhoo Park, Myung-Soon Shin, Woo-Tack Song, Hye Sil Seol, Seung-Sook Lee
BACKGROUND: It is difficult to correctly diagnose follicular neoplasms (FNs) on fine-needle aspiration cytology (FNAC) because it shares many cytological features with other mimicking lesions. The aim of this study was to identify the cytological features that differentiate FNs from mimicking lesions. METHODS: We included the cytological slides from 116 cases of thyroid FN diagnosed on FNAC, and included their subsequent histological diagnoses. We evaluated the cytological architectural pattern and nuclear features of the lesions according to their histological groups...
March 2018: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/29281871/fine-needle-aspiration-cytology-of-carcinosarcoma-in-the-salivary-gland-an-extremely-rare-case-report
#14
Hyo Jung An, Hye Jin Baek, Jin Pyeong Kim, Min Hye Kim, Dae Hyun Song
Carcinosarcoma of the salivary gland is an extremely rare tumor that is composed of both malignant epithelial and mesenchymal components. Diagnosing carcinosarcoma with fine-needle aspiration cytology is challenging because of its overlapping cytomorphologic characteristics with other high-grade malignant salivary gland tumors. Among the many features, including pleomorphic oncocytoid epithelial components, necrotic background, and mitoses, recognizing the singly scattered atypical spindle cells is most essential in carcinosarcoma...
March 2018: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/29268593/multiple-neuroendocrine-tumors-in-stomach-and-duodenum-in-a-multiple-endocrine-neoplasia-type-1-patient
#15
Bohyun Kim, Han-Kwang Yang, Woo Ho Kim
A 67-year-old woman with a history of subtotal parathyroidectomy, distal pancreatectomy, and total splenectomy 23 years prior underwent surgical gastric resection for neuroendocrine tumors of the stomach and duodenum. Meticulous examination of the entire stomach and duodenum revealed multiple scattered, minute neuroendocrine tumors. To the best of our knowledge, this is the first case report of a patient diagnosed with gastroduodenal neuroendocrine tumors associated with multiple endocrine neoplasia type 1 (MEN 1) in whom complete histologic mapping of the whole gastrectomy specimen was performed...
March 2018: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/29172395/the-clinicopathological-and-prognostic-significance-of-the-gross-classification-of-hepatocellular-carcinoma
#16
Yangkyu Lee, Hyunjin Park, Hyejung Lee, Jai Young Cho, Yoo-Seok Yoon, Young-Rok Choi, Ho-Seong Han, Eun Sun Jang, Jin-Wook Kim, Sook-Hyang Jeong, Soomin Ahn, Haeryoung Kim
BACKGROUND: We aimed to determine the clinicopathological significance of the gross classification of hepatocellular carcinoma (HCC) according to the Korean Liver Cancer Association (KLCA) guidelines. METHODS: A retrospective analysis was performed on 242 cases of consecutively resected solitary primary HCC between 2003 and 2012 at Seoul National University Bundang Hospital. The gross classification (vaguely nodular [VN], expanding nodular [EN], multinodular confluent [MC], nodular with perinodular extension [NP], and infiltrative [INF]) was reviewed for all cases, and were correlated with various clinicopathological features and the expression status of "stemness"-related (cytokeratin 19 [CK19], epithelial cell adhesion molecule [EpCAM]), and epithelial-mesenchymal transition (EMT)-related (urokinase plasminogen activator receptor [uPAR] and Ezrin) markers...
March 2018: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/29121459/extramural-perineural-invasion-in-pt3-and-pt4-gastric-carcinomas
#17
Alejandro España-Ferrufino, Leonardo S Lino-Silva, Rosa A Salcedo-Hernández
BACKGROUND: Perineural invasion (PNI) is widely studied in malignant tumors, and its prognostic significance is well demonstrated. Most studies have focused on evaluating the mural PNI (mPNI); however, extramural PNI (ePNI) may influence the prognosis in gastric cancer. We evaluated the prognostic value of ePNI compared with mPNI in gastric cancer in this observational comparative cross-sectional study. METHODS: Seventy-three pT3 and pT4 gastric carcinomas with PNI were evaluated...
March 2018: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/29046514/protein-phosphatase-magnesium-dependent-1%C3%AE-ppm1d-expression-as-a-prognostic-marker-in-adult-supratentorial-diffuse-astrocytic-and-oligodendroglial-tumors
#18
Hui Jeong Jeong, Chang Gok Woo, Bora Lee, Shin Kwang Khang, Soo Jeong Nam, Jene Choi
BACKGROUND: Protein phosphatase magnesium-dependent 1δ (PPM1D) is a p53-induced serine/threonine phosphatase, which is overexpressed in various human cancers. A recent study reported that a mutation in the PPM1D gene is associated with poor prognosis in brainstem gliomas. In this study, we evaluated the utility of PPM1D as a prognostic biomarker of adult supratentorial diffuse astrocytic and oligodendroglial tumors. METHODS: To investigate PPM1D protein expression, mRNA expression, and copy number changes, immunohistochemistry, RNAscope in situ hybridization, and fluorescence in situ hybridization were performed in 84 adult supratentorial diffuse gliomas...
March 2018: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/28994275/combined-adenosquamous-and-large-cell-neuroendocrine-carcinoma-of-the-gallbladder
#19
Jiyoon Jung, Yang-Seok Chae, Chul Hwan Kim, Youngseok Lee, Jeong Hyeon Lee, Dong-Sik Kim, Young-Dong Yu, Joo Young Kim
Large cell neuroendocrine carcinoma (LCNEC) of the gallbladder is extremely rare and usually combined with other type of malignancy, mostly adenocarcinoma. We report an unusual case of combined adenosquamous carcinoma and LCNEC of the gallbladder in a 54-year-old woman. A radical cholecystectomy specimen revealed a 4.3×4.0 cm polypoid mass in the fundus with infiltration of adjacent liver parenchyma. Microscopically, the tumor consisted of two distinct components. Adenosquamous carcinoma was predominant and abrupt transition from adenocarcinoma to squamous cell carcinoma was observed...
March 2018: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/28372343/osteosarcomatous-differentiation-in-rebiopsy-specimens-of-pulmonary-adenocarcinoma-with-egfr-tki-resistance
#20
Hyein Ahn, Hyun Jung Kwon, Eunhyang Park, Hyojin Kim, Jin-Haeng Chung
No abstract text is available yet for this article.
March 2018: Journal of Pathology and Translational Medicine
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