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Journal of Pathology and Translational Medicine

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https://www.readbyqxmd.com/read/27750407/cerebellar-liponeurocytoma-relevant-clinical-cytogenetic-findings
#1
Alexander Tucker, Kritsanapol Boon-Unge, Nancy McLaughlin, Hassana Ibrahim, Nagesh Rao, Neil Martin, Richard Everson, Négar Khanlou
No abstract text is available yet for this article.
October 16, 2016: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/27744658/size-of-non-lepidic-invasive-pattern-predicts-recurrence-in-pulmonary-mucinous-adenocarcinoma-morphologic-analysis-of-188-resected-cases-with-reappraisal-of-invasion-criteria
#2
Soohyun Hwang, Joungho Han, Misun Choi, Myung-Ju Ahn, Yong Soo Choi
Background: We reviewed a series of 188 resected pulmonary mucinous adenocarcinomas (MAs) to clarify the prognostic significance of lepidic and non-lepidic patterns. Materials and Methods: Non-lepidic patterns were divided into bland, non-distorted acini with uncertain invasiveness (pattern 1), unequivocal invasion into stroma (pattern 2), or invasion into alveolar spaces (pattern 3). Results: The mean percentage of invasive patterns (patterns 2 and 3) was lowest in small (≤3 cm) tumors, and gradually increased in intermediate (>3 cm and ≤7 cm) and large (>7 cm) tumors (8...
October 16, 2016: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/27744656/increased-expression-of-thymosin-%C3%AE-4-is-independently-correlated-with-hypoxia-inducible-factor-1%C3%AE-hif-1%C3%AE-and-worse-clinical-outcome-in-human-colorectal-cancer
#3
Seung Yun Lee, Mee Ja Park, Hye Kyung Lee, Hyun Jin Son, Chang Nam Kim, Joo Heon Kim, Dong Wook Kang
Background: Thymosin β4 is a multi-functional hormone-like polypeptide, being involved in cell migration, angiogenesis, and tumor metastasis. This study was undertaken to clarify the clinico-pathologic implications of thymosin β4 expression in human colorectal carcinomas (CRCs). Materials and Methods: We investigated tissue sections from 143 patients with CRC by immunohistochemistry. In addition, we evaluated the expression patterns and the clinico-pathological significance of thymosin β4 expression in association with hypoxia inducible factor-1α (HIF-1α) expression in the CRC series...
October 16, 2016: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/27737528/diagnostic-significance-of-cellular-neuroglial-tissue-in-ovarian-immature-teratoma
#4
Yun Chai, Chang Gok Woo, Joo-Young Kim, Chong Jai Kim, Shin Kwang Khang, Jiyoon Kim, In Ah Park, Eun Na Kim, Kyu-Rae Kim
Background: Immature teratoma (IT) is a tumor containing immature neuroectodermal tissue, primarily in the form of neuroepithelial tubules. However, the diagnosis of IT containing only cellular neuroglial tissue (CNT) without distinct neuroepithelial tubules is often difficult, since the histological characteristics of immature neuroectodermal tissues remain unclear. Here, we examined the significance of CNT and defined immature neuroectodermal tissues by comparing the histological features of neuroglial tissues between mature teratoma (MT) and IT...
October 14, 2016: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/27809448/immunohistochemistry-for-pathologists-protocols-pitfalls-and-tips
#5
REVIEW
So-Woon Kim, Jin Roh, Chan-Sik Park
Immunohistochemistry (IHC) is an important auxiliary method for pathologists in routine diagnostic work as well as in basic and clinical research including exploration of biomarkers, as IHC allows confirmation of target molecule expressions in the context of microenvironment. Although there has been a considerable progress in automation and standardization of IHC, there are still many things to be considered in proper optimization and appropriate interpretation. In this review, we aim to provide possible pitfalls and useful tips for practicing pathologists and residents in pathology training...
November 2016: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/27780340/cd9-expression-in-colorectal-carcinomas-and-its-prognostic-significance
#6
Kyung-Ju Kim, Hee Jung Kwon, Min Chong Kim, Young Kyung Bae
BACKGROUND: CD9, a member of the tetraspanin superfamily, is a tumor suppressor in many malignancies. The aim of this study was to evaluate the immunohistochemical expression of CD9 in colorectal carcinomas (CRCs) and determine clinicopathological and prognostic significance of its expression. METHODS: The CD9 expression status of 305 CRCs was evaluated using a semi-quantitative scoring system in tumor cells (T-CD9) and immune cells (I-CD9) by classifying the results as high and low expression...
November 2016: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/27744657/pathogenesis-of-focal-segmental-glomerulosclerosis
#7
REVIEW
Beom Jin Lim, Jae Won Yang, Woo Sung Do, Agnes B Fogo
Focal segmental glomerulosclerosis (FSGS) is characterized by focal and segmental obliteration of glomerular capillary tufts with increased matrix. FSGS is classified as collapsing, tip, cellular, perihilar and not otherwise specified variants according to the location and character of the sclerotic lesion. Primary or idiopathic FSGS is considered to be related to podocyte injury, and the pathogenesis of podocyte injury has been actively investigated. Several circulating factors affecting podocyte permeability barrier have been proposed, but not proven to cause FSGS...
November 2016: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/27737529/morphological-and-functional-changes-in-the-thyroid-follicles-of-the-aged-murine-and-humans
#8
Junguee Lee, Shinae Yi, Yea Eun Kang, Hyeon-Woo Kim, Kyong Hye Joung, Hae Joung Sul, Koon Soon Kim, Minho Shong
BACKGROUND: Although both thyroid histology and serum concentrations of hormones are known to change with age, only a few reports exist on the relationship between the age-related structural and functional changes of the thyroid follicles in both mice and humans. Our objectives were to investigate age-related histological changes of the thyroid follicles and to determine whether these morphological changes were associated with the functional activity of the follicles. METHODS: The thyroid glands of mice at 18 weeks and at 6, 15, and 30 months of age were histologically examined, and the serum levels of thyroid hormones were measured in 11-week-old and 20-month-old mice...
November 2016: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/27725621/comparison-of-the-fda-and-asco-cap-criteria-for-her2-immunohistochemistry-in-upper-urinary-tract-urothelial-carcinoma
#9
Gilhyang Kim, Yul Ri Chung, Bohyun Kim, Boram Song, Kyung Chul Moon
BACKGROUND: Human epidermal growth factor receptor 2 (HER2) is one of the known oncogenes in urothelial carcinoma. However, the association between HER2 and the prognosis of upper urinary tract urothelial carcinoma (UUTUC) has not yet been fully clarified. The aim of this study was to evaluate HER2 expression using the United States Food and Drug Administration (FDA) criteria and American Society of Clinical Oncology/College of American Pathologists (ASCO/CAP) criteria and compare their prognostic significance in UUTUC...
November 2016: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/27725620/detection-of-human-papillomavirus-in-korean-breast-cancer-patients-by-real-time-polymerase-chain-reaction-and-meta-analysis-of-human-papillomavirus-and-breast-cancer
#10
Jinhyuk Choi, Chungyeul Kim, Hye Seung Lee, Yoo Jin Choi, Ha Yeon Kim, Jinhwan Lee, Hyeyoon Chang, Aeree Kim
BACKGROUND: Human papillomavirus (HPV) is a well-established oncogenic virus of cervical, anogenital, and oropharyngeal cancer. Various subtypes of HPV have been detected in 0% to 60% of breast cancers. The roles of HPV in the carcinogenesis of breast cancer remain controversial. This study was performed to determine the prevalence of HPV-positive breast cancer in Korean patients and to evaluate the possibility of carcinogenic effect of HPV on breast. METHODS: Meta-analysis was performed in 22 case-control studies for HPV infection in breast cancer...
November 2016: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/27725619/does-polymerase-chain-reaction-of-tissue-specimens-aid-in-the-diagnosis-of-tuberculosis
#11
Yoo Jin Lee, Seojin Kim, Youngjin Kang, Jiyoon Jung, Eunjung Lee, Joo-Young Kim, Jeong Hyeon Lee, Youngseok Lee, Yang-Seok Chae, Chul Hwan Kim
BACKGROUND: Mycobacterial culture is the gold standard test for diagnosing tuberculosis (TB), but it is time-consuming. Polymerase chain reaction (PCR) is a highly sensitive and specific method that can reduce the time required for diagnosis. The diagnostic efficacy of PCR differs, so this study determined the actual sensitivity of TB-PCR in tissue specimens. METHODS: We retrospectively reviewed 574 cases. The results of the nested PCR of the IS6110 gene, mycobacterial culture, TB-specific antigen-induced interferon-γ release assay (IGRA), acid-fast bacilli (AFB) staining, and histological findings were evaluated...
November 2016: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/27713217/the-predictive-value-of-pathologic-features-in-pituitary-adenoma-and-correlation-with-pituitary-adenoma-recurrence
#12
Jee Soon Kim, Youn Soo Lee, Min Jung Jung, Yong Kil Hong
BACKGROUND: The 2004 World Health Organization classification introduced atypical pituitary adenoma (aPA), which was equivocally defined as invasion with increased mitotic activity that had a Ki-67 labeling index (LI) greater than 3%, and extensive p53 immunoreactivity. However, aPAs that exhibit all of these features are rare and the predictive value for recurrence in pituitary adenomas (PAs) remains uncertain. Thus, we sought to characterize pathological features of PAs that correlated with recurrence...
November 2016: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/27452081/a-case-of-malignant-pecoma-of-the-uterus-associated-with-intramural-leiomyoma-and-endometrial-carcinoma
#13
Yoo Jin Choi, Jin Hwa Hong, Aeree Kim, Hankyeom Kim, Hyeyoon Chang
Perivascular epithelioid cell tumors (PEComas) refers to a family of mesenchymal neoplasms composed of angiomyolipomas, clear cell "sugar" tumors of the lung, and lymphangioleiomyomatoses. These tumors have a distinctive and common component of perivascular epithelioid cells that show an association with blood vessel walls and immunohistochemically display myomelanocytic differentiation. The unique neoplasms have been shown to have an expanded range through a variety of case reports, including visceral, intra-abdominal, soft tissue, and bone tumors...
November 2016: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/27237132/goblet-cell-carcinoid-of-the-rectum-in-a-patient-with-neurofibromatosis-type-1
#14
Youngjin Kang, Jung-Woo Choi, Younghye Kim, Hwa Eun Oh, Ju-Han Lee, Young-Sik Kim
No abstract text is available yet for this article.
November 2016: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/27214574/a-case-of-giant-colonic-muco-submucosal-elongated-polyps-associated-with-intussusception
#15
Joo Heon Kim, Seung Yun Lee, Je Ho Jang, Hyun Young Han, Dong Wook Kang
Colonic muco-submucosal elongated polyp (CMSEP), a newly categorized non-neoplastic colorectal polyp, is a pedunculated and elongated polyp composed of normal mucosal and submucosal layers without any proper muscle layer. We herein report a giant variant of CMSEP associated with intussusception in the rectosigmoid colon, with a review of the literature. A 48-year-old woman underwent a laparoscopic low anterior resection due to multiple large submucosal polypoid masses associated with intussusception. Grossly, the colonic masses were multiple pedunculated polyps with a long stalk and branches ranging in size from a few millimeters to 14...
November 2016: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/27156512/primary-follicular-lymphoma-of-the-duodenum-a-case-report
#16
Jin Roh, Jooryung Huh, Chan-Sik Park
No abstract text is available yet for this article.
November 2016: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/27681413/do-helper-t-cell-subtypes-in-lymphocytic-thyroiditis-play-a-role-in-the-antitumor-effect
#17
Seok Woo Yang, Seong-Ho Kang, Kyung Rae Kim, In Hong Choi, Hang Seok Chang, Young Lyun Oh, Soon Won Hong
BACKGROUND: Papillary thyroid carcinoma (PTC) is frequently accompanied by lymphocytic thyroiditis (LT). Some reports claim that Hashimoto's thyroiditis (the clinical form of LT) enhances the likelihood of PTC; however, others suggest that LT has antitumor activity. This study was aimed to find out the relationship between the patterns of helper T cell (Th) cytokines in thyroid tissue of PTC with or without LT and the clinicopathological manifestation of PTC. METHODS: Fresh surgical samples of PTC with (13 cases) or without (10 cases) LT were used...
September 2016: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/27580127/clinicopathologic-correlations-of-e-cadherin-and-prrx-1-expression-loss-in-hepatocellular-carcinoma
#18
Kijong Yi, Hyunsung Kim, Yumin Chung, Hyein Ahn, Jongmin Sim, Young Chan Wi, Ju Yeon Pyo, Young-Soo Song, Seung Sam Paik, Young-Ha Oh
BACKGROUND: Developing predictive markers for hepatocellular carcinoma (HCC) is important, because many patients experience recurrence and metastasis. Epithelial to mesenchymal transition (EMT) is a developmental process that plays an important role during embryogenesis and also during cancer metastasis. Paired-related homeobox protein 1 (Prrx-1) is an EMT inducer that has recently been introduced, and its prognostic significance in HCC is largely unknown. METHODS: Tissue microarray was constructed using surgically resected primary HCCs from 244 cases...
September 2016: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/27550048/difference-of-the-nuclear-green-light-intensity-between-papillary-carcinoma-cells-showing-clear-nuclei-and-non-neoplastic-follicular-epithelia-in-papillary-thyroid-carcinoma
#19
Hyekyung Lee, Tae Hwa Baek, Meeja Park, Seung Yun Lee, Hyun Jin Son, Dong Wook Kang, Joo Heon Kim, Soo Young Kim
BACKGROUND: There is subjective disagreement regarding nuclear clearing in papillary thyroid carcinoma. In this study, using digital instruments, we were able to quantify many ambiguous pathologic features and use numeric data to express our findings. METHODS: We examined 30 papillary thyroid carcinomas. For each case, we selected representative cancer cells showing clear nuclei and surrounding non-neoplastic follicular epithelial cells and evaluated objective values of green light intensity (GLI) for quantitative analysis of nuclear clearing in papillary thyroid carcinoma...
September 2016: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/27550047/long-non-coding-rna-hotair-expression-in-diffuse-large-b-cell-lymphoma-in-relation-to-polycomb-repressive-complex-pathway-proteins-and-h3k27-trimethylation
#20
Eun Ji Oh, Soo Hee Kim, Woo Ick Yang, Young Hyeh Ko, Sun Och Yoon
BACKGROUND: A long non-coding RNA hox transcript antisense intergenic RNA (HOTAIR) is involved in epigenetic regulation through chromatin remodeling by recruiting polycomb repressive complex 2 (PRC2) proteins (EZH2, SUZ12, and EED) that induce histone H3 trimethylation at lysine 27 (H3K27me3). Deregulation of c-MYC and interaction between c-MYC and EZH2 are well known in lymphomagenesis; however, little is known about the expression status of HOTAIR in diffuse large B-cell lymphomas (DLBCLs)...
September 2016: Journal of Pathology and Translational Medicine
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