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Journal of Pathology and Translational Medicine

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https://www.readbyqxmd.com/read/29902913/pulmonary-nodular-lymphoid-hyperplasia-with-mass-formation-clinicopathologic-characteristics-of-nine-cases-and-review-of-the-literature
#1
Jongmin Sim, Hyun Hee Koh, Sangjoon Choi, Jinah Chu, Tae Sung Kim, Hojoong Kim, Joungho Han
Background: Pulmonary nodular lymphoid hyperplasia (PNLH) is a non-neoplastic pulmonary lymphoid disorder that can be mistaken for malignancy on radiography. Herein, we present nine cases of PNLH, emphasizing clinicoradiological findings and histological features. Materials and Methods: We analyzed radiological and clinicopathological features from the electronic medical records of nine patients (eight females and one male) diagnosed with PNLH. IgG and IgG4 immunohistochemical staining was performed in three patients...
June 15, 2018: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/29902914/cytologic-diagnosis-of-metastatic-alveolar-rhabdomyosarcoma-in-cerebrospinal-fluid-a-case-report
#2
Bobae Shim, Jiwon Koh, Ji Hye Moon, In Ae Park, Han Suk Ryu
Rhabdomyosarcoma is a malignant soft tissue tumor which shows skeletal muscle differentiation. Leptomeningeal metastasis can occur as a late complication, but currently there are no reports that have documented the cytologic features in cerebrospinal fluid (CSF). We report a case of metastatic alveolar rhabdomyosarcoma diagnosed in the CSF of a 28-year-old male who was originally diagnosed with rhabdomyosarcoma on the neck, and that went through systemic therapy. The tumor was positive for anaplastic lymphoma kinase, but progressed despite additional therapy with crizotinib...
June 14, 2018: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/29890568/hyalinizing-trabecular-tumor-of-the-thyroid-gland-a-diagnostic-challenge-in-fine-needle-aspiration-cytology-case-report
#3
Ye-Young Rhee, Hong Kyu Jung, Se Hoon Kim, Soo Hee Kim
Hyalinizing trabecular tumor (HTT) is a rare thyroid tumor with low to minimal malignant potential. HTT is often misinterpreted as other thyroid tumors, including papillary thyroid carcinoma (PTC) and medullary thyroid carcinoma (MTC), on fine-needle aspiration (FNA) cytology, because of its overlapping cytologic features, such as nuclear grooves and intranulcear pseudoinclusions. Although cytopathologists cannot definitely conclude HTT by FNA cytology, suspicion of HTT is necessary to avoid misdiagnosing HTT as PTC or MTC and to avoid unnecessary aggressive treatment...
June 11, 2018: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/29874901/crystal-storing-histiocytosis-with-plasma-cell-neoplasm-in-the-setting-of-chronic-carbamazepine-exposure
#4
Woo Cheal Cho, Safina Hafeez, Peter Shen
No abstract text is available yet for this article.
June 7, 2018: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/29874900/malignant-pleural-effusion-from-metastatic-prostate-cancer-a-case-report-with-unusual-cytologic-findings
#5
Jinyoung Jeon, Tae-Jung Kim, Hong Sik Park, Kyo-Young Lee
We present a case of 55-year-old man who complained of dyspnea and sputum for a month. He was an ex-smoker having a history of prostate cancer and pulmonary tuberculosis. Chest radiographs revealed small to moderate amount of bilateral pleural effusions. Pigtail catheters were inserted and drainage was performed. The pleural fluid contained malignant cells, arranged in large clusters and tightly cohesive groups. These cytologic findings could not with certainty be ascribed to prostate cancer. We performed immunocytochemical (ICH) panel studies to determine the origin of cancer metastasis...
June 7, 2018: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/29794961/combined-hepatocellular-carcinoma-and-neuroendocrine-carcinoma-with-ectopic-secretion-of-parathyroid-hormone-a-case-report-and-review-of-the-literature
#6
Hyun Jung Kwon, Ji-Won Kim, Haeryoung Kim, YoungRok Choi, Soomin Ahn
Primary combined hepatocellular carcinoma (HCC) and neuroendocrine carcinoma is a rare entity, and so is hypercalcemia due to ectopic parathyroid hormone (PTH) secretion by tumor. A 44-year old male with hepatitis B virus associated chronic liver disease presented with a hepatic mass. Hemihepatectomy discovered the mass as combined HCC and poorly differentiated cholangiocarcinoma. During adjuvant chemoradiation therapy, he presented with nausea, and multiple systemic metastases were found. Laboratory tests revealed hypercalcemia with markedly elevated PTH and neuron specific enolase...
May 25, 2018: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/29747485/sudden-child-death-due-to-thrombotic-giant-coronary-artery-aneurysms-complicated-by-atypical-kawasaki-disease-an-autopsy-case
#7
DongJa Kim, Man-Hoon Han, SangHan Lee
No abstract text is available yet for this article.
May 11, 2018: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/29673240/the-major-role-of-nf-%C3%AE%C2%BAb-in-the-depth-of-invasion-on-acral-melanoma-by-decreasing-cd8-t-cells
#8
Hermin Aminah Usman, Bethy S Hernowo, Maringan Diapari Lumban Tobing, Reti Hindritiani
BACKGROUND: The tumor microenvironment including immune surveillance affects malignant melanoma (MM) behavior. Nuclear factor κB (NF-κB) stimulates the transcription of various genes in the nucleus and plays a role in the inflammatory process and in tumorigenesis. CD8+ T cells have cytotoxic properties important in the elimination of tumors. However, inhibitory receptors on the cell surface will bind to programmed death-ligand 1 (PD-L1), causing CD8+ T cells to lose their ability to initiate an immune response...
May 2018: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/29621880/let-archived-paraffin-blocks-be-utilized-for-research-with-waiver-of-informed-consent
#9
REVIEW
Yong-Jin Kim, Jeong Sik Park, Karam Ko, Chang Rok Jeong
Advances in biomedical and genetic research have contributed to more effective public health improvement via bench-to-bed research and the emergence of personalized medicine. This has certainly showcased the importance of archived human tissues, especially paraffin-embedded blocks in pathology. Currently in Korea, undue legislative regulations of the Bioethics and Safety Act suspend and at times discourage studies from taking place. In this paper, the authors underline the value of paraffin blocks in the era of personalized and translational medicine...
May 2018: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/29614546/cytologic-diagnosis-of-noninvasive-follicular-thyroid-neoplasm-with-papillary-like-nuclear-features-and-its-impact-on-the-risk-of-malignancy-in-the-bethesda-system-for-reporting-thyroid-cytopathology-an-institutional-experience
#10
Milim Kim, Joung Eun Kim, Hyun Jeong Kim, Yul Ri Chung, Yoonjin Kwak, So Yeon Park
BACKGROUND: This study was performed to analyze cytologic diagnosis of noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) and its impact on the risk of malignancy (ROM) in the Bethesda System for Reporting Thyroid Cytopathology (TBSRTC). METHODS: Five thousand five hundred and forty-nine cases of thyroid fine-needle aspiration cytology (FNAC) diagnosed between 2012 and 2014 were included in this study. Diagnostic categories based on TBSRTC were compared with final surgical diagnoses, and the ROM in each category was calculated both when NIFTP was included in malignant lesions and when excluded from malignant lesions...
May 2018: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/29590746/utility-of-braf-ve1-immunohistochemistry-as-a-screening-tool-for-colorectal-cancer-harboring-braf-v600e-mutation
#11
Jeong-Hwa Kwon, Byung-Kwan Jeong, Yong Sik Yoon, Chang Sik Yu, Jihun Kim
BACKGROUND: BRAF mutation has been recognized as an important biomarker of colorectal cancer (CRC) for targeted therapy and prognosis prediction. However, sequencing for every CRC case is not cost-effective. An antibody specific for BRAF V600E mutant protein has been introduced, and we thus examined the utility of BRAF VE1 immunohistochemistry for evaluating BRAF mutations in CRC. METHODS: Fifty-one BRAF -mutated CRCs and 100 age and sexmatched BRAF wild-type CRCs between 2005 and 2015 were selected from the archives of Asan Medical Center...
May 2018: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/29575851/molecular-screening-of-small-biopsy-samples-using-next-generation-sequencing-in-korean-patients-with-advanced-non-small-cell-lung-cancer-korean-lung-cancer-consortium-klcc-13-01
#12
Bo Mi Ku, Mi Hwa Heo, Joo-Hang Kim, Byoung Chul Cho, Eun Kyung Cho, Young Joo Min, Ki Hyeong Lee, Jong-Mu Sun, Se-Hoon Lee, Jin Seok Ahn, Keunchil Park, Tae Jung Kim, Ho Yun Lee, Hojoong Kim, Kyung-Jong Lee, Myung-Ju Ahn
BACKGROUND: Non-small cell lung cancer (NSCLC) is a common type of cancer with poor prognosis. As individual cancers exhibit unique mutation patterns, identifying and characterizing gene mutations in NSCLC might help predict patient outcomes and guide treatment. The aim of this study was to evaluate the clinical adequacy of molecular testing using next-generation sequencing (NGS) for small biopsy samples and characterize the mutational landscape of Korean patients with advanced NSCLC...
May 2018: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/29281782/duodenal-adenocarcinoma-of-brunner-gland-origin-a-case-report
#13
Ji Hye Moon, Kyoungbun Lee, Han-Kwang Yang, Woo Ho Kim
We report a case of adenocarcinoma originating from the duodenal Brunner glands in a 47-year-old female patient. The lesion was 0.8 cm in extent and located at the posterior wall of the first part of the duodenum. Histologically, the tumor showed transition from non-neoplastic Brunner glands through dysplastic epithelium into adenocarcinoma. The carcinoma cells were strongly positive for MUC6 protein, which is an epithelial marker for the Brunner glands. Tumor protein p53 was overexpressed in the carcinoma cells, but not in the non-neoplastic or dysplastic epithelium...
May 2018: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/29281781/erdheim-chester-disease-involving-lymph-nodes-and-liver-clinically-mimicking-lymphoma-a-case-report
#14
Yeoun Eun Sung, Yoon Seo Lee, Jieun Lee, Kyo Young Lee
Erdheim-Chester disease (ECD) is a rare non-Langerhans cell histiocytosis and multisystem disease. First described in 1930, there are no more than 750 cases reported. The etiology remains unknown, but a majority of cases of ECD and Langerhans cell histiocytosis were found to have clonal mutations involving genes of the mitogen-activated protein kinase pathway. We recently encountered a 53-year-old male patient with extensive ECD involving the systemic lymph nodes, pleura, liver, and long bones clinically mimicking malignant lymphoma...
May 2018: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/29268594/aberrant-cd3-expression-in-a-relapsed-plasma-cell-neoplasm
#15
Jai-Hyang Go
No abstract text is available yet for this article.
May 2018: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/29166764/merkel-cell-carcinoma-metastatic-to-pleural-fluid-a-case-report
#16
Ye-Young Rhee, Soo Hee Kim, Eun Kyung Kim, Se Hoon Kim
Merkel cell carcinoma (MCC) is a rare aggressive neuroendocrine carcinoma of the skin that shows locoregional or distant metastasis. Metastasis of MCC to body cavity effusion is extremely rare; only three cases have been reported so far. Metastatic MCC in effusion cytology shows small blue round cells with fine stippled chromatin like other small blue round cell tumors such as small cell lung carcinoma or lymphoma. The diagnosis of metastatic MCC can grant patients good chances at recently advanced therapeutic options...
May 2018: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/28994273/secretory-carcinoma-arising-in-a-fibroadenoma-a-brief-case-report
#17
Sharon Lim, Min Keun Shim, Eun Yoon Cho, Soo Youn Cho
No abstract text is available yet for this article.
May 2018: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/28774160/post-transplant-amputation-traumatic-neuroma-of-the-hilum-and-extrahepatic-duct-in-a-liver-donor
#18
Na Rae Kim, Hyun Yee Cho, Dong Hae Chung, Keon Kuk Kim, Jae Hee Cho, Seung Joon Choi
No abstract text is available yet for this article.
May 2018: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/28683521/expression-of-cd34-and-%C3%AE-catenin-in-malignant-rhabdoid-tumor-of-the-liver-mimicking-proximal-type-epithelioid-sarcoma
#19
Woo Cheal Cho, Fabiola Balarezo
No abstract text is available yet for this article.
May 2018: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/29621879/recurrent-indeterminate-dendritic-cell-tumor-of-the-skin
#20
Jin Woo Joo, Taek Chung, Yoon Ah Cho, Sang Kyum Kim
Indeterminate dendritic cell tumor (IDCT) is a dendritic cell tumor that displays histologic features similar to those of Langerhans cells. The origin of the indeterminate cells may represent precursors of Langerhans cells or skin dendritic cells. IDCT is extremely rare, and tumor progression and predictive factors are not well known. Here, we report a case of a 61-year-old man who presented with a papule on his back and was finally diagnosed with IDCT based on histology and immunohistochemistry. The tumor recurred months after surgical excision...
April 5, 2018: Journal of Pathology and Translational Medicine
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