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IJC Heart & Vasculature

Barbara S Kahlow, Renato Nisihara, Roberta Petisco, Shirley R R Utiyama, Iara J Messias-Reason, Isabela Goeldner, Thelma L Skare
Background: Mannose binding lectin (MBL) appears to be involved in susceptibility to rheumatoid arthritis (RA), in the inflammatory process and in the genesis of atherosclerotic disease. Objective: To study the association of MBL serum levels and its genotypic variation with carotid arteries intimal thickness (IMT) in RA patients from Southern Brazil. Methods: MBL serum levels, MBL2 genotyping and IMT were investigated in 90 RA patients along with their demographic, clinical and laboratory profile...
September 2018: IJC Heart & Vasculature
Marco Magnoni, Guglielmo Gallone, Ferruccio Ceriotti, Vittoria Vergani, Daniela Giorgio, Giulia Angeloni, Attilio Maseri, Domenico Cianflone
Background: High-sensitivity cardiac troponin T (hsTnT) was recently approved for clinical use by the Food and Drug Administration. The transition from contemporary to hsTnT assays requires a thorough understanding of the clinical differences between these assays. Hypothesis: HsTnT may provide a more accurate prognostic stratification than contemporary cardiac troponin I (cTnI) in patients with non-ST-segment elevation acute coronary syndromes (NSTE-ACS). Methods: HsTnT and cTnI were measured in 644 patients with CK-MB negative NSTE-ACS who were enrolled in the prospective multicenter SPAI (Stratificazione Prognostica dell'Angina Instabile) study...
September 2018: IJC Heart & Vasculature
Marcello Disertori, Michela Masè, Marta Rigoni, Giandomenico Nollo, Flavia Ravelli
Background: Inducibility of ventricular arrhythmias at electrophysiological study (EPS) has long been suggested as predictive for subsequent arrhythmic events. Nevertheless, the usefulness of EPS in the clinical practice is still unclear. We performed a systematic review and meta-analysis to assess the predictive power of EPS in primary prevention of ventricular arrhythmias in post-myocardial infarction (MI) patients with left ventricular dysfunction. Methods: MEDLINE and the Cochrane Library databases were systematically searched to identify studies, which analyzed EPS predictive value in post-MI patients with mean EF < 40% for the composite arrhythmic endpoint defined by: sudden cardiac death (SCD), aborted SCD, ventricular tachycardia (VT), ventricular fibrillation (VF), appropriate implantable cardioverter-defibrillator (ICD) interventions...
September 2018: IJC Heart & Vasculature
Sunao Kojima, Kensaku Nishihira, Misa Takegami, Yoko M Nakao, Satoshi Honda, Jun Takahashi, Morimasa Takayama, Hiroaki Shimokawa, Tetsuya Sumiyoshi, Hisao Ogawa, Kazuo Kimura, Satoshi Yasuda
Background: Cardiovascular diseases, including acute myocardial infarction (AMI), are leading causes of death among the Japanese, who have the longest life expectancy in the world. Over the past 50 years in Japan, the percentage of elderly individuals has increased 4-fold, from 5.7% in 1960 to 23.1% in 2010. To explore medical practices and emergency care for AMI in this aging society, the Japan Acute Myocardial Infarction Registry (JAMIR) was established as a nationwide real-world database...
September 2018: IJC Heart & Vasculature
Dominik Linz, Mathias Hohl, Dobromir Dobrev
No abstract text is available yet for this article.
June 2018: IJC Heart & Vasculature
Alberto Aimo, Chiara Seghieri, Sabina Nuti, Michele Emdin
No abstract text is available yet for this article.
June 2018: IJC Heart & Vasculature
Xiaoyang Du, Adina Khamitova, Mattias Kyhlstedt, Sun Sun, Mathilde Sengoelge
Background: Heart failure represents a major public health issue that impacts 26 million people globally. Currently, real-world data represents a key instrument for providing the verification of both internal and external validity, yet there is still a lack of understanding regarding its scope in complementing evidence of treatments for heart failure. This study aims to increase understanding of the utilisation of real-word data from heart failure registries in Organisation for Economic Co-operation and Development (OECD) countries...
June 2018: IJC Heart & Vasculature
Francesco Moroni, Enrico Ammirati, Maria A Rocca, Massimo Filippi, Marco Magnoni, Paolo G Camici
Diseases affecting the brain contribute to a substantial proportion of morbidity and mortality in the general population. Conditions such as stroke, dementia and cognitive impairment have a prominent impact on global public health. Despite the heterogeneous clinical manifestations of these conditions and their diverse prognostic implications, current evidence supports a role for cardiovascular disease as a common pathophysiological ground. Brain white matter hyperintensities (WMH) are patchy white matter signal hyperintensity on T2-weighted magnetic resonance imaging sequences commonly found in elderly individuals...
June 2018: IJC Heart & Vasculature
Sung Il Im, Seok Hyun Kim, Bong Joon Kim, Kyoung Im Cho, Hyun Su Kim, Jung Ho Heo
Introduction: Premature ventricular complex (PVCs) detected from long-term ECG recordings have been associated with an increased risk of ischemic stroke. However, there was limited data about the association between high PVCs burdens (>10%) and stroke-like symptoms without a prior diagnosis of stroke or transient ischemic attack in the long-term follow up. Methods: The Kosin University 24-hours holter monitoring, echocardiography, electrocardiogram (ECG) database were reviewed from 2013 to 2015 to identify patients with frequent PVCs (>10%)...
June 2018: IJC Heart & Vasculature
Toru Morofuji, Makoto Saito, Shinji Inaba, Hiroe Morioka, Takumi Sumimoto
Background: Lesions in the proximal left coronary artery (LCA) are associated with a poor prognosis compared with other lesional sites. Transthoracic Doppler echocardiography (TTDE) can help to detect proximal LCA flow, and an accelerated coronary flow velocity (CFV) indicates the presence of proximal LCA lesions. This study aimed to investigate the prognostic value of CFV in the proximal LCA measured by TTDE. Methods: We enrolled 1472 consecutive hemodynamically stable patients with known or suspected heart disease whose CFV was successfully detected using TTDE accompanied by routine echocardiography between 2008 and 2011...
June 2018: IJC Heart & Vasculature
Tsuyoshi Nozue, Takeshi Takamura, Kazuki Fukui, Takashi Sozu, Yuji Tanaka, Kiyoshi Hibi, Satoru Kishi, Ichiro Michishita
Background: The use of coronary computed tomography angiography (CCTA) for noninvasive anatomic detection of coronary artery disease is increasing. Recently, fractional flow reserve (FFR) assessment using routinely acquired CCTA datasets (FFRCT ) has been developed. However, there are no reports about changes in coronary atherosclerosis, composition, and FFRCT in patients with type 2 diabetes. Methods: This prospective, multicenter, observational trial evaluated changes in coronary atherosclerosis after alogliptin therapy in patients with type 2 diabetes...
June 2018: IJC Heart & Vasculature
Bryan P Yan, Jacquelyn Chi-Ying Fok, Teddy Hong-Yee Wong, Gary Tse, Alex P W Lee, Xing-Sheng Yang, Jing-Ping Sun
Background: Focused cardiac ultrasound (FOCUS) examination using a portable device is increasingly used for bedside diagnosis of cardiovascular diseases. This is a 4-week pilot project aiming to teach medical students to perform FOCUS to detect valvular heart lesions. Methods: Patients undergoing routine transthoracic echocardiography (TTE) were recruited by third year medical students who performed physical examination (PE) and FOCUS after 6-hour training to detect significant (moderate-to-severe) valvular lesions...
June 2018: IJC Heart & Vasculature
David S Wald, Ben J Wald, Angus Radford, Alex Shipolini
Background: The sternal wire code records details of coronary artery bypass surgery (CABG) inside patients, based on the orientation of wires used for sternal closure. Visible on X-ray, the code overcomes the problem of missing graft-notes needed before repeat angiography. We determined (i) the potential value (ii) acceptability and (iii) accuracy of the code in practice. Methods: (i) Consecutive coronary angiogram reports (2015-2016 Barts, London) were reviewed to identify patients with previous CABG and those with and without graft-notes before angiography...
June 2018: IJC Heart & Vasculature
Katsunori Nonogaki, Mari Murakami, Tomoe Yamazaki, Naohiko Nonogaki
Background: The aims of the present study were to determine the effects of an ultrasound irradiation on clinic hypertension and the heart rate variability in elderly hypertensive subjects with type 2 diabetes. Methods: We examined the effects of ultrasound (800 kHz, 25 mW/cm2 ) applied to the forearm for 10 min on the autonomic nerve activity and the difference between BP at home and at a clinic visit in Japanese subjects with type 2 diabetes and hypertension...
June 2018: IJC Heart & Vasculature
Tomoaki Hama, Keiko Oikawa, Akiko Ushijima, Norishige Morita, Takashi Matsukage, Yu-Ji Ikari, Yoshinori Kobayashi
Background: Whether an individually determined appropriate level of cardiac rehabilitation (CR) has a favorable effect on the renal function still remains unclarified. The aim of this study was to confirm the effect of CR on the estimated glomerular filtration rate (eGFR) using cystatin C, which is known to be unaffected by physical exercise. Methods: The study population was comprised of 86 patients (61 males; average age 74 y/o) with a lower-moderate level of chronic kidney disease (CKD) who was admitted to our hospital for treatment of cardiovascular disease (CVD) and who participated in our 3-month CR program...
June 2018: IJC Heart & Vasculature
Camilla Skals Engelsgaard, Kenneth Bruun Pedersen, Lars Peter Riber, Peter Appel Pallesen, Axel Brandes
Background: Atrial fibrillation (AF) is the most common cardiac arrhythmia, and associated with increased risk of morbidity and mortality. AF surgery is widely used for rhythm control of AF, but previous studies have shown varying results. This study sought to investigate the long-term efficacy of concomitant maze IV (CMIV) surgery in an unselected AF population and identify predictors of late AF recurrence. Methods: In total 144 consecutive patients, who underwent CMIV between January 2006 and December 2010 were enrolled...
June 2018: IJC Heart & Vasculature
Tom Jackson, Radoslaw Lenarczyk, Maciej Sterlinski, Adam Sokal, Darrell Francis, Zachary Whinnett, Frederic Van Heuverswyn, Marc Vanderheyden, Joeri Heynens, Berthold Stegemann, Richard Cornelussen, Christopher Aldo Rinaldi
Background: We sought to determine whether presence, amount and distribution of scar impacts the degree of acute hemodynamic response (AHR) with multisite pacing.Multi-vein pacing (MVP) or multipolar pacing (MPP) with a multi-electrode left ventricular (LV) lead may offer benefits over conventional biventricular pacing in patients with myocardial scar. Methods: In this multi-center study left bundle branch block patients underwent an hemodynamic pacing study measuring LV dP/dtmax ...
June 2018: IJC Heart & Vasculature
Simon Claridge, Natalia Briceno, Zhong Chen, Kalpa De Silva, Bhavik Modi, Tom Jackson, Jonathan M Behar, Steven Niederer, Christopher A Rinaldi, Divaka Perera
Background: Biventricular pacing has been shown to increase both cardiac contractility and coronary flow acutely but the causal relationship is unclear. We hypothesised that changes in coronary flow are secondary to changes in cardiac contractility. We sought to examine this relationship by modulating coronary flow and cardiac contractility. Methods: Contractility and lusitropy were altered by varying the location of pacing in 8 patients. Coronary autoregulation was transiently disabled with intracoronary adenosine...
June 2018: IJC Heart & Vasculature
Kazuhiro Harada, Ryosuke Kikuchi, Hideki Ishii, Yohei Shibata, Susumu Suzuki, Akihito Tanaka, Atsuo Suzuki, Kenshi Hirayama, Toyoaki Murohara
Background: Vascular endothelial growth factor-A (VEGF-A) promotes neovascularization and is attracting considerable attention as a remarkable risk factor in patients after acute myocardial infarction (AMI). In contrast, the association between VEGF-A165 b, which is the main anti-angiogenic isoform of VEGF-A, and adverse clinical outcomes after AMI remains unclear. The present study aimed to investigate the association between serum VEGF-A165 b and major adverse cardiac and cerebrovascular events (MACCEs) after percutaneous coronary intervention (PCI) for AMI...
June 2018: IJC Heart & Vasculature
Mauro Vaccarezza, Cristina Balla, Paola Rizzo
No abstract text is available yet for this article.
June 2018: IJC Heart & Vasculature
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