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IJC Heart & Vasculature

Hiromoto Sone, Hiroyoshi Mori, Tokutada Sato, Yosuke Takei, Kazuma Tashiro, Masahiro Sasai, Hiroshi Suzuki
No abstract text is available yet for this article.
December 2018: IJC Heart & Vasculature
Manda L Keller-Ross, Daniel P Chantigian, Nicholas Evanoff, Anne E Bantle, Donald R Dengel, Lisa S Chow
Ventilation/carbon dioxide production (VE /VCO2slope ) is used clinically to determine cardiorespiratory fitness and morbidity in heart failure (HF). Previously, we demonstrated that lower lean leg mass is associated with high VE /VCO2slope during exercise in HF. In healthy individuals, we evaluated 1) whether VE /VCO2slope differed between lean and overweight women and 2) the relationship between lean leg mass and VE /VCO2slope in overweight sedentary (OWS), overweight trained (OWTR) and lean, trained (LTR) women...
December 2018: IJC Heart & Vasculature
Jeannine Lang, Stefan Buettner, Helge Weiler, Nestoras Papadopoulos, Helmut Geiger, Ingeborg Hauser, Mariuca Vasa-Nicotera, Andreas Zeiher, Stephan Fichtlscherer, Joerg Honold
Background: Kidney transplant recipients (KTR) reflect a high-risk population for coronary artery disease (CAD). CAD is the most common cause for morbidity and mortality in this population. However, only few data are available on the favourable revascularization strategy for these patients as they were often excluded from studies and not mentioned in guidelines. Methods: This retrospective single-centre study includes patients with a history of kidney transplantation undergoing myocardial revascularization for multivessel or left main CAD by either percutaneous coronary intervention (PCI, n = 27 patients) or coronary artery bypass grafting (CABG, n = 24 patients) at University Hospital Frankfurt, Germany, between 2005 and 2015...
December 2018: IJC Heart & Vasculature
Brian Young, Wayne Franklin, Wilson Lam, Peter Ermis
No abstract text is available yet for this article.
December 2018: IJC Heart & Vasculature
Ayman M Helal, Sameh M Shaheen, Walid A Elhammady, Mohamed I Ahmed, Ahmed S Abdel-Hakim, Lamyaa E Allam
Background: The rationale for pharmacoinvasive strategy is that many patients have a persistent reduction in flow in the infarct-related artery. The aim of the present study is to assess safety and efficacy of pharmacoinvasive strategy using streptokinase compared to primary PCI and ischemia driven PCI on degree of myocardial salvage and outcomes. Methods and results: Sixty patients with 1st attack of acute STEMI within 12 h were randomized to 4 groups: primary PCI for patients presented to PPCI-capable centers (group I), transfer to PCI if presented to non-PCI capable center (group II), pharmacoinvasive strategy "Streptokinase followed by PCI within 3-24 h" (group III) and fibrinolytic followed by ischemia driven PCI (group IV)...
December 2018: IJC Heart & Vasculature
Francesco Maranta, Lorenzo Cianfanelli, Maria Regoni, Domenico Cianflone
The prevalence of type 2 diabetes continues to increase and cardiovascular (CV) diseases remain the leading cause of death in diabetic patients. Diabetologists and Cardiologists have to work together in order to provide the best management to these patients. After years of disappointing studies showing no reduction of CV events with strict glycaemic control, some of the novel glucose-lowering drugs (GLDs) seem to offer a new approach to tackle the problem, since the CV outcome trials (CVOTs-D) of liraglutide, semaglutide, empagliflozin and canagliflozin have demonstrated not only their CV safety but also their efficacy in the reduction of CV morbidity and mortality...
December 2018: IJC Heart & Vasculature
Kumar Ashish, Dhrubajyoti Bandyopadhyay, Raktim K Ghosh, Jian Liang Tan, Subhasish Bose
No abstract text is available yet for this article.
December 2018: IJC Heart & Vasculature
Ali Momeni, Abdolmajid Taheri, Maryam Mansuri, Ali Bazdar, Morteza Sedehi, Masoud Amiri
Aims: Atherosclerosis and ischemic heart disease are more common in diabetic patients. Atherosclerosis process can disturb the normal functioning of the vascular endothelium and increase vessel wall thickness. The aim of this study was the comparison of Carotid intima-media thickness (CIMT) with Exercise tolerance test as an alternative way to evaluate cardiac ischemia in diabetic patients. Methods: In a cross-sectional study, 30 diabetic patients with positive exercise test and 30 diabetic patients with negative exercise test were enrolled...
December 2018: IJC Heart & Vasculature
Shinichi Nonin, Shinichi Iwata, Asahiro Ito, Soichiro Tamura, Ryoko Kitada, Yu Kawai, Sera Ishikawa, Atsushi Doi, Akihisa Hanatani, Minoru Yoshiyama
Background: Tolvaptan is a vasopressin type 2 receptor antagonist used in heart failure (HF) with refractory diuretic resistance. However, since tolvaptan is also ineffective in some HF patients with reduced ejection fraction (HFrEF), the identification of responders is important. Methods: The study population consisted of 51 HFrEF patients who were administered tolvaptan (EF, 28 ± 7%). We defined responders as patients with a ≥50% increase in urine volume during the 24-hours after administration of tolvaptan...
December 2018: IJC Heart & Vasculature
Guilherme Oberto Rodrigues, Rogério Fachel Medeiros, Sergio Chaves Rodrigues, Liliana Fortini Cavalheiro Boll, Maria Claudia Irigoyen, Silvia Goldmeier
Aims: To compare the dosage of radiation the thyroid and gonad glands receive in pediatric patients undergoing chest X-rays, in distinct positions, towards the goal of developing of an X-ray tube positioning protocol. Methods: A randomized controlled clinical trial was carried out in the Pediatric Intensive Care Unit (PICU) at the Institute of Cardiology/University Foundation of Cardiology of Rio Grande do Sul, Brazil from June 2014 to September 2016. Patients were divided into two groups...
December 2018: IJC Heart & Vasculature
Yue Zheng, Tong Li
Background: In recent years, many people are opting for minimally invasive surgery in China. Patients undergoing transcatheter aortic valve implantation or replacement (TAVIR) with previous coronary artery bypass grafting (CABG) have higher risks of death and major complications. Materials/methods: PubMed and Embase were searched for all comparison studies between TAVIR with and without prior CABG and mortality as a primary outcome, irrespective of surgical risk, to investigate whether patients with prior CABG can undergo TAVIR...
December 2018: IJC Heart & Vasculature
Erkan Coban
No abstract text is available yet for this article.
December 2018: IJC Heart & Vasculature
Dirk Prochnau, Konstantin von Knorre, Hans-Reiner Figulla, P Christian Schulze, Ralf Surber
Background: We sought to evaluate a temperature-guided approach of cryoballoon (CB) ablation without visualization of real-time recordings. Methods and results: We analysed 166 patients (34.9% female, 60 ± 11 years) with paroxysmal or short-term persistent atrial fibrillation (AF). Comorbidities included diabetes mellitus (n = 28), coronary artery disease (n = 24), hypertension (n = 122), previous stroke or TIA > 3 months (n = 12)...
December 2018: IJC Heart & Vasculature
Rafael Amorim Belo Nunes, Larissa Barbosa Lima, Nelson Ithiro Tanaka, Alexandre da Costa Pereira, José Eduardo Krieger, Alfredo José Mansur
Background: Physiological pathways such as bradykinin, renin-angiotensin, neurohormones and nitric oxide have been shown to play an important role in the regulation of cardiovascular function. Genetic variants of these pathways may impact blood pressure and left ventricular (LV) mass in different populations. To evaluate associations of genetic polymorphisms of bradykinin B2 receptor (BDKRB2), alpha-adrenergic receptors (ADRA) and endothelial nitric oxide synthase (eNOS) on the modulation of the blood pressure and the left ventricular mass...
December 2018: IJC Heart & Vasculature
Ampadu-Okyere Jackson, Mugwaneza Annick Regine, Chakrabarti Subrata, Shiyin Long
Atherosclerosis (AS) manifested by lipid accumulation, extracellular matrix protein deposition, and calcification in the intima and media of the large to medium size arteries promoting arterial stiffness and reduction of elasticity. It has been accepted that AS leads to increased morbidity and mortality worldwide. Recent studies indicated that genetic abnormalities play an important role in the development of AS. Specific genetic mutation and histone modification have been found to induce AS formation. Furthermore, specific RNAs such as microRNAs and circular RNAs have been identified to play a crucial role in the progression of AS...
December 2018: IJC Heart & Vasculature
Enrico Ammirati, Francesco Moroni, Marco Magnoni, Elena Busnardo, Simona Di Terlizzi, Chiara Villa, Federico Sizzano, Isabella Scotti, Alessio Palini, Luca Presotto, Valentino Bettinardi, Pietro Spagnolo, Francesca Besana, Luigi Gianolli, Ornella E Rimoldi, Paolo G Camici
Background: We explored the relation between blood concentrations of monocyte/lymphocyte subsets and carotid artery plaque macrophage content, measured by positron emission tomography (PET) with 11 C-PK11195. Methods and results: In 9 patients with carotid plaques we performed 11 C-PK11195-PET/computed tomography angiography imaging and measurement of absolute concentrations and frequencies of circulating monocytes and T-cell subsets. Plaque standardized uptake value (SUV) for 11 C-PK11195 was negatively correlated with concentrations of total monocytes (r = -0...
December 2018: IJC Heart & Vasculature
Kristopher Kow, Timothy James Watson, David Foo, Hee Hwa Ho
Background: There is limited data on the natural history of Takotsubo (stress-induced) cardiomyopathy in South-East Asian patients. We aim to evaluate the clinical characteristics, predisposing factors and outcomes of patients diagnosed with Takotsubo cardiomyopathy in our region. Methods: From January 2010 to March 2017, 98 patients were diagnosed with Takotsubo cardiomyopathy in our institution. Data were collected retrospectively on baseline clinical characteristics, presenting symptoms, precipitating factors, clinical investigations and in-hospital clinical outcomes...
December 2018: IJC Heart & Vasculature
Luis Dos Santos, Ednei L Antonio, Andrey J Serra, Amanda Yoshizaki, Larissa Seibt, Flavio A Silva, Gisele K Couto, Luciana V Rossoni, Paulo Tucci, Angelo A de Paola, Guilherme Fenelon
Background: Atrial fibrillation (AF) frequently coexists with congestive heart failure (CHF). The increased susceptibility to AF in CHF has been attributed to a variety of structural and electrophysiological changes in the atria, particularly dilation and interstitial fibrosis. We evaluated atrial remodeling and AF vulnerability in a rat model of CHF induced by left ventricle (LV) radiofrequency (RF) ablation. Methods: Wistar rats were divided into 3 groups: RF-induced CHF (Ab, n = 36), CHF animals treated with spironolactone (AbSpi, n = 20) and sham controls (Sham, n = 29)...
December 2018: IJC Heart & Vasculature
Tomás Benito-González, Rodrigo Estévez-Loureiro, Armando Pérez de Prado, Carlos Minguito-Carazo, Samuel Del Castillo García, Carmen Garrote-Coloma, Ignacio Iglesias-Gárriz, David Alonso-Rodríguez, Javier Gualis Cardona, Carlos Cuellas Ramón, María López Benito, Julia Vidán Estévez, Felipe Fernández-Vázquez
Objectives: MitraClip is an established therapy for patients with mitral regurgitation (MR) that are considered of high-risk or inoperable. However, late bleeding events (BE) after hospital discharge and their impact on prognosis in this cohort of patients have been poorly investigated. Our purpose is to address the incidence, related factors and clinical implications of BE after hospital discharge in patients treated with MitraClip. Methods: Prospective registry of all consecutive patients (n = 80) who underwent MitraClip implantation in our Institution between June 2014 and December 2017...
December 2018: IJC Heart & Vasculature
Gheorghe-Andrei Dan, Dobromir Dobrev
Rhythm and rate strategies are considered equivalent for the management of atrial fibrillation (AF). Moreover, both strategies are intended for improving symptoms and quality of life. Despite the clinical availability of several antiarrhythmic drugs (AAD) the alternatives for the patient with comorbidities are significantly fewer because of the concern regarding many adverse effects, including proarrhythmias. The impetuous development of AF ablation gave rise to a false impression that AAD are a second line therapy...
December 2018: IJC Heart & Vasculature
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