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Translational Lung Cancer Research

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https://www.readbyqxmd.com/read/29535915/pragmatic-trial-of-a-multidisciplinary-lung-cancer-care-model-in-a-community-healthcare-setting-study-design-implementation-evaluation-and-baseline-clinical-results
#1
Matthew P Smeltzer, Fedoria E Rugless, Bianca M Jackson, Courtney L Berryman, Nicholas R Faris, Meredith A Ray, Meghan Meadows, Anita A Patel, Kristina S Roark, Satish K Kedia, Margaret M DeBon, Fayre J Crossley, Georgia Oliver, Laura M McHugh, Willeen Hastings, Orion Osborne, Jackie Osborne, Toni Ill, Mark Ill, Wynett Jones, Hyo K Lee, Raymond S Signore, Roy C Fox, Jingshan Li, Edward T Robbins, Kenneth D Ward, Lisa M Klesges, Raymond U Osarogiagbon
Background: Responsible for 25% of all US cancer deaths, lung cancer presents complex care-delivery challenges. Adoption of the highly recommended multidisciplinary care model suffers from a dearth of good quality evidence. Leading up to a prospective comparative-effectiveness study of multidisciplinary vs. serial care, we studied the implementation of a rigorously benchmarked multidisciplinary lung cancer clinic. Methods: We used a mixed-methods approach to conduct a patient-centered, combined implementation and effectiveness study of a multidisciplinary model of lung cancer care...
February 2018: Translational Lung Cancer Research
https://www.readbyqxmd.com/read/29535914/radial-endobronchial-ultrasonography-with-distance-measurement-through-a-thin-bronchoscope-for-the-diagnosis-of-malignant-peripheral-pulmonary-lesions
#2
Su-Juan Zhang, Ming Zhang, Jun Zhou, Qiu-Di Zhang, Qian-Qian Xu, Xiong Xu
Background: Peripheral pulmonary lesions (PPLs) are being discovered more frequently. We investigated efficiency, safety, and influencing factors in radial probe endobronchial ultrasound with distance measurement (rEBUS-D) using a thin bronchoscope during transbronchial biopsy (TBB) for the diagnosis of malignant PPLs. Methods: Patients with PPLs who underwent rEBUS were retrospectively analyzed. Cases with rEBUS-D and a gold-standard final diagnosis were considered...
February 2018: Translational Lung Cancer Research
https://www.readbyqxmd.com/read/29535913/current-standards-for-clinical-management-of-small-cell-lung-cancer
#3
REVIEW
Anna F Farago, Florence K Keane
Small cell lung cancer (SCLC) is an aggressive high-grade neuroendocrine carcinoma. Despite over 30 years of clinical research, little progress has been made in the management of SCLC, and outcomes remain poor. Here, we review the current clinical standards for management of SCLC and the data supporting these strategies.
February 2018: Translational Lung Cancer Research
https://www.readbyqxmd.com/read/29535912/targeting-dna-damage-repair-in-small-cell-lung-cancer-and-the-biomarker-landscape
#4
REVIEW
Triparna Sen, Carl M Gay, Lauren Averett Byers
Small cell lung cancer (SCLC) is an aggressive malignancy that accounts for 14% of all lung cancer diagnoses. Despite decades of active research, treatment options for SCLC are limited and resistance to the few Food and Drug Administration (FDA) approved therapies develops rapidly. With no approved targeted agents to date, new therapeutic strategies are desperately needed. SCLC is characterized by high mutation burden, ubiquitous loss of TP53 and RB1, mutually exclusive amplification of MYC family members, thereby, high genomic instability...
February 2018: Translational Lung Cancer Research
https://www.readbyqxmd.com/read/29535911/small-cell-lung-cancer-tumors-and-preclinical-models-display-heterogeneity-of-neuroendocrine-phenotypes
#5
Wei Zhang, Luc Girard, Yu-An Zhang, Tomohiro Haruki, Mahboubeh Papari-Zareei, Victor Stastny, Hans K Ghayee, Karel Pacak, Trudy G Oliver, John D Minna, Adi F Gazdar
Background: Small cell lung cancer (SCLC) is a deadly, high grade neuroendocrine (NE) tumor without recognized morphologic heterogeneity. However, over 30 years ago we described a SCLC subtype with "variant" morphology which did not express some NE markers and exhibited more aggressive growth. Methods: To quantitate NE properties of SCLCs, we developed a 50-gene expression-based NE score that could be applied to human SCLC tumors and cell lines, and genetically engineered mouse (GEM) models...
February 2018: Translational Lung Cancer Research
https://www.readbyqxmd.com/read/29535910/tumor-heterogeneity-in-small-cell-lung-cancer-defined-and-investigated-in-pre-clinical-mouse-models
#6
REVIEW
Yan Ting Shue, Jing Shan Lim, Julien Sage
Small cell lung carcinoma (SCLC) is a fast-growing, highly metastatic form of lung cancer. A major difference between SCLC and other forms of lung cancer is that SCLC tumors often respond well to chemotherapy initially; unfortunately, resistant tumors rapidly recur. In addition, despite a large number of clinical trials with a variety of therapeutic agents, little progress has been achieved in the past three decades in improving the survival of SCLC patients. These clinical observations indicate that SCLC tumors have a high degree of plasticity and rapid adaptability to changes in growth conditions...
February 2018: Translational Lung Cancer Research
https://www.readbyqxmd.com/read/29535909/transcriptional-deregulation-underlying-the-pathogenesis-of-small-cell-lung-cancer
#7
REVIEW
Dong-Wook Kim, Keun-Cheol Kim, Kee-Beom Kim, Colin T Dunn, Kwon-Sik Park
The discovery of recurrent alterations in genes encoding transcription regulators and chromatin modifiers is one of the most important recent developments in the study of the small cell lung cancer (SCLC) genome. With advances in models and analytical methods, the field of SCLC biology has seen remarkable progress in understanding the deregulated transcription networks linked to the tumor development and malignant progression. This review will discuss recent discoveries on the roles of RB and P53 family of tumor suppressors and MYC family of oncogenes in tumor initiation and development...
February 2018: Translational Lung Cancer Research
https://www.readbyqxmd.com/read/29535908/small-cell-lung-cancer-updates-and-new-concepts
#8
Peter Ujhazy, O Wolf Lindwasser
No abstract text is available yet for this article.
February 2018: Translational Lung Cancer Research
https://www.readbyqxmd.com/read/29532809/editorial-on-pancan-study
#9
EDITORIAL
Henry M Marshall, Ian A Yang, Rayleen V Bowman, Kwun M Fong
No abstract text is available yet for this article.
February 2018: Translational Lung Cancer Research
https://www.readbyqxmd.com/read/29531918/professor-fred-r-hirsch-together-our-voices-are-much-stronger-than-individually-a-special-interview-about-the-2017-lung-cancer-awareness-month-campaign
#10
Chao-Xiu Melanie He
No abstract text is available yet for this article.
February 2018: Translational Lung Cancer Research
https://www.readbyqxmd.com/read/29531917/professor-raymond-u-osarogiagbon-another-major-challenge-over-next-decades-how-to-incorporate-the-cutting-edge-diagnostics-and-biologic-prognosticating-ability-into-a-traditionally-anatomy-centered-tnm-staging-system
#11
https://www.readbyqxmd.com/read/29531916/professor-david-ball-prophylactic-cranial-irradiation-pci-benefits-patients-with-sclc
#12
Macy Liu
No abstract text is available yet for this article.
February 2018: Translational Lung Cancer Research
https://www.readbyqxmd.com/read/29531915/professor-fred-r-hirsch-the-iaslc-ceo-showing-you-around-the-18th-world-conference-on-lung-cancer-wclc-2017
#13
Lynn Ma, Chao-Xiu Melanie He
No abstract text is available yet for this article.
February 2018: Translational Lung Cancer Research
https://www.readbyqxmd.com/read/29531914/dr-ignacio-gil-bazo-family-support-is-my-key-to-success
#14
Brad Li, Vicky Wong
No abstract text is available yet for this article.
February 2018: Translational Lung Cancer Research
https://www.readbyqxmd.com/read/29531913/dr-vera-hirsh-improving-patient-s-quality-of-life-is-necessary-for-cancer-treatment
#15
Brad Li, Vicky Wong
No abstract text is available yet for this article.
February 2018: Translational Lung Cancer Research
https://www.readbyqxmd.com/read/29531912/dr-jhingook-kim-surgeons-are-not-merely-technicians-but-scientists
#16
Brad Li
No abstract text is available yet for this article.
February 2018: Translational Lung Cancer Research
https://www.readbyqxmd.com/read/29531911/dr-david-ross-camidge-always-be-the-first-to-see-something
#17
Brad Li, Maxine Feng
No abstract text is available yet for this article.
February 2018: Translational Lung Cancer Research
https://www.readbyqxmd.com/read/29531910/dr-lucio-crin%C3%A3-our-greatest-challenge-is-finding-the-right-treatment-for-the-right-patients
#18
Brad Li, Bella Poon
No abstract text is available yet for this article.
February 2018: Translational Lung Cancer Research
https://www.readbyqxmd.com/read/29531909/prof-nir-peled-ct-first-biomarkers-next
#19
Brad Li, Lilian Xie
No abstract text is available yet for this article.
February 2018: Translational Lung Cancer Research
https://www.readbyqxmd.com/read/29531908/prof-lukas-bubendorf-the-pros-and-cons-of-using-cytology-specimens-in-molecular-testing
#20
Brad Li, Vanessa Zhao
No abstract text is available yet for this article.
February 2018: Translational Lung Cancer Research
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