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Military Medical Research

Xiuxiu Lv, Huadong Wang
Sepsis-induced myocardial dysfunction is a common complication in septic patients and is associated with increased mortality. In the clinical setting, it was once believed that myocardial dysfunction was not a major pathological process in the septic patients, at least in part, due to the unavailability of suitable clinical markers to assess intrinsic myocardial function during sepsis. Although sepsis-induced myocardial dysfunction has been studied in clinical and basic research for more than 30 years, its pathophysiology is not completely understood, and no specific therapies for this disorder exist...
2016: Military Medical Research
Hua-Yu Zhang, Dong Liu, Hao Tang, Shi-Jin Sun, Shan-Mu Ai, Wen-Qun Yang, Dong-Po Jiang, Lian-Yang Zhang
BACKGROUND: Intra-abdominal hypertension (IAH) is a disease with high morbidity and mortality among critically ill patients. The study's objectives were to explore the prevalence of IAH and physicians' awareness of the 2013 World Society of Abdominal Compartment Syndrome (WSACS) guidelines in Chinese intensive care units (ICUs). METHODS: A cross-sectional study of four ICUs in Southwestern China was conducted from June 17 to August 2, 2014. Adult patients admitted to the ICU for more than 24 h, with bladder catheter but without obvious intravesical pressure (IVP) measurement contraindications, were recruited...
2016: Military Medical Research
Karl-Christian Münter
The German wound healing society ICW (Initiative Chronische Wunden) started a training program for nurses in 2005. Certified by TÜV Rheinland the courses are regularly audited and the quality is ensured. More than 30,000 nurses attended these courses in Germany. In three Chinese hospitals the ICW courses have been adopted. A close collaboration between Chinese and German experts in wound healing let to their further development and improvement. The article reviews the need for education in the treatment of chronic wounds for medical personnel-nurses and doctors...
2016: Military Medical Research
Ashish Malhotra, K C Mandip, Aasma Shaukat, Thomas Rector
BACKGROUND: Inflammatory bowel diseases (IBDs) are group of chronic inflammatory illnesses with a remitting and relapsing course that may result in appreciable morbidity and high medical costs secondary to repeated hospitalizations. The study's objectives were to identify the reasons for hospitalization among patients with inflammatory bowel diseases, and compare inpatient courses and readmission rates for IBD-related admissions versus non-IBD-related admissions. METHODS: A retrospective chart review was performed on all patients with IBD admitted to the Minneapolis VA Medical Center between September 2010 and September 2012...
2016: Military Medical Research
Hui Wang, Rui-Yun Peng
With key roles in essential brain functions ranging from the long-term potentiation (LTP) to synaptic plasticity, the N-methyl-D-aspartic acid receptor (NMDAR) can be considered as one of the fundamental glutamate receptors in the central nervous system. The role of NMDA R was first identified in synaptic plasticity and has been extensively studied. Some molecules, such as Ca(2+), postsynaptic density 95 (PSD-95), calcium/calmodulin-dependent protein kinase II (CaMK II), protein kinase A (PKA), mitogen-activated protein kinase (MAPK) and cyclic adenosine monophosphate (cAMP) responsive element binding protein (CREB), are of special importance in learning and memory...
2016: Military Medical Research
Deng-Ming Lai, Qiang Shu, Jie Fan
Innate lymphoid cells (ILCs), a newly identified member of the lymphoid population, play a critical role in the transition from innate to adaptive immunity in host defense. ILCs are important in mucosal barrier immunity, tissue homeostasis, and immune regulation throughout the body. Significant alterations in ILC responses in lung diseases have been observed and reported. Emerging evidence has shown that ILCs are importantly involved in the pathogenesis and development of a variety of lung diseases, i.e., helminth infections, allergic airway inflammation, and airway hyper-responsiveness...
2016: Military Medical Research
Biao Cheng, Shu-Liang Lu, Xiao-Bing Fu
Regenerative medicine (RM) is an emerging interdisciplinary field of research and China has developed the research quickly and impressed the world with numerous research findings in stem cells, tissue engineering, active molecules and gene therapy. Important directions are induced differentiation of induced pluripotent stem and embryo stem cells as well as somatic stem cell differentiation potential and their application in trauma, burns, diseases of aging and nerve regeneration. The products ActivSkin and bone repair scaffolds have been approved and are applied in the clinic, and similar products are being studied...
2016: Military Medical Research
David E Winchester, Nayan Agarwal, Lucas Burke, Steven Bradley, Tatiana Schember, Carsten Schmalfuss
BACKGROUND: Cardiac troponin assays have improved the ability to detect myocardial damage. However, ascertaining whether troponin elevation is due to myocardial infarction (MI) or secondary to another process can be challenging. Our aim is to evaluate provider-level variation in the diagnosis of MI and the use of invasive coronary angiography (ICA) among patients with undifferentiated elevations in cardiac troponin. METHODS: We analyzed data from all patients with elevated troponin levels in a single Veterans Affairs (VA) Medical Center between 2006 and 2007...
2016: Military Medical Research
Latha Ganti, Yasamin Daneshvar, Sarah Ayala, Aakash N Bodhit, Keith R Peters
BACKGROUND: Traditionally, neurocognitive testing is performed weeks to months after head injury and is mostly performed on patients who continue to have symptoms or difficulties. In this study, we sought to determine whether these tests, when administered acutely, could assist in predicting short-term outcomes after acute traumatic brain injury (TBI). METHODS: This is an IRB-approved prospective study of adult patients who came to the emergency department of our Level-1 trauma center with TBI...
2016: Military Medical Research
S Manoj, A Mukherjee, S Johri, K V S Hari Kumar
BACKGROUND: Rabies is a zoonosis transmitted via the bites of various mammals, primarily dogs and bats. Known since antiquity, this disease may have the deadliest human fatality rates and is responsible for approximately 65,000 deaths worldwide per year. CASE PRESENTATION: We report the case details of a 13-year-old boy from India belonging to a South Asian ethnicity, who presented with altered sensorium one month following a dog bite. He did not receive the active rabies immunization and was managed with supportive therapy...
2016: Military Medical Research
Hagen Frickmann, Sven A Jungblut
BACKGROUND: Asymptomatic and oligosymptomatic appendicitis are rare and challenging diagnoses that should not be missed. CASE PRESENTATION: A young female patient presented with mild to moderate pain in the middle and lower abdomen, and the results of physical examination, including digital rectal examination, were otherwise non-contributory. Ultrasonography demonstrated a marked increase of the outer appendiceal diameter up to 12 mm and a trace of free liquid around the terminal ileum...
2016: Military Medical Research
Young Wan Kim
BACKGROUND: Intussusception refers to a condition in which a segment of the intestine invaginates into the lumen of an adjacent segment of the intestine. Postoperative intussusception after gastrointestinal surgery is an uncommon clinical condition, and there is only one case report of small bowel intussusception after rectal cancer surgery. Here, we report a case of spontaneous small bowel intussusception following laparoscopic total mesorectal excision for rectal cancer. CASE PRESENTATION: A 56-year-old female military officer was referred to the Colorectal Surgical Department for mid-rectal cancer, 8 cm from the anal verge...
2016: Military Medical Research
K V S Hari Kumar, K P Shijith, F M H Ahmad
BACKGROUND: Bell's palsy is a common condition seen in clinical practice. The aetiology of this condition is not clearly defined and neuroimaging is essential to exclude intracranial causes of infra-nuclear facial palsy. CASE PRESENTATION: We report a young soldier, who presented with Bell's palsy and neuroimaging revealed an unsuspected finding of multiple intracranial calcifications. Detailed evaluation revealed the additional diagnosis of vitamin D deficiency and secondary hyperparathyroidism due to lack of sun exposure at high altitude area...
2016: Military Medical Research
Risaku Fukumoto
Acute radiation syndrome affects military personnel and civilians following the uncontrolled dispersal of radiation, such as that caused by detonation of nuclear devices and inappropriate medical treatments. Therefore, there is a growing need for medical interventions that facilitate the improved recovery of victims and patients. One promising approach may be cell therapy, which, when appropriately implemented, may facilitate recovery from whole body injuries. This editorial highlights the current knowledge regarding the use of mesenchymal stem cells for the treatment of acute radiation syndrome, the benefits and limitations of which are under investigation...
2016: Military Medical Research
Xiao-Bing Fu
The editors of Military Medical Research would like to thank all our reviewers who have contributed to the journal in volume 1 (2014) and 2 (2015).
2016: Military Medical Research
Qing Liu, Ren-Lai Zhou, Xin Zhao, Xiao-Ping Chen, Shan-Guang Chen
Recently, studies on the extent to which spaceflight affects the psychology of individuals has received attention. In order to reveal the mental challenges that humans face in space, we need practical viewpoints to integrate the psychological effects, behavior, performance and the environment itself for space exploration. The present review discusses the individual variables related to space psychology and manned spaceflight, in addition to their growing trends. These items include patterns of emotional changes in extreme environments and the approaches to evaluating emotions...
2016: Military Medical Research
Bing Xie, Ming Liang, Da-Peng Zhou, Wen Zhao, Jing-Yang Sun, Jing-Jing Rong, Jing Tian
BACKGROUND: Pelvic fracture combined with massive bleeding (PFCMB) is a complex issue in clinical practice. Currently, the use of angiography and embolization for the treatment of PFCMB obtains good results. The aim of this study is to observe the effects of early internal iliac artery embolization on the SIRS in dogs with simulated-pelvic-fracture combined with massive bleeding. METHODS: Twenty adult dogs were randomly divided into an embolization group (EG) and a control group (CG)...
2016: Military Medical Research
Xin Zhao, Xiao-Xu Yang, Su-Zhen Ji, Xiao-Zeng Wang, Li Wang, Chong-Huai Gu, Li-Li Ren, Ya-Ling Han
BACKGROUND: In worldwide, the mortality rate of acute myocardial infarction (AMI) raises year by year. Although the applications of percutaneous coronary intervention (PCI) and anticoagulants effectively reduce the mortality of patients with acute coronary syndrome (ACS), but also increase the incidence of bleeding. Therefore, drugs with stable anticoagulant effects are urgently required. METHODS: We enrolled 894 patients with acute coronary syndrome who underwent percutaneous coronary intervention in Shenyang Northern Hospital from February 2010 to May 2012; 430 patients were included in the fondaparinux group (2...
2016: Military Medical Research
Stefan Sammito, Nils Gundlach, Irina Böckelmann
BACKGROUND: Physical fitness tests are widely used to assess endurance, sprint ability, coordination and/or strength. The objective of the present study was to analyze the degree to which the results of the Bundeswehr Basis Fitness Test (BFT)--a physical fitness test comprising a sprint test (11 × 10-m shuttle test), a flexed-arm hang test and a 1000-m run--are consistent with the output measured during a bicycle ergometer test. The number of false-positive and false-negative results with regard to the assessment of physical fitness were also examined...
2016: Military Medical Research
Hasanat Alamgir, Caryn A Turner, Nicole J Wong, Sharon P Cooper, Jose A Betancourt, James Henry, Andrew J Senchak, Tanisha L Hammill, Mark D Packer
The objectives of this research were to 1) summarize the available evidence on the impact of hearing loss on quality of life (QOL) among U.S. active-duty service members, 2) describe the QOL instruments that have been used to quantify the impact of hearing loss on quality of life, 3) examine national population-level secondary databases and report on their utility for studying the impact of hearing loss on QOL among active-duty service members, and 4) provide recommendations for future studies that seek to quantify the impact of hearing loss in this population...
2016: Military Medical Research
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