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Basic and Clinical Andrology

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https://www.readbyqxmd.com/read/30410765/epididymal-approaches-to-male-contraception
#1
REVIEW
Joël R Drevet
Today, a vast arsenal of contraceptive methods interfering at different levels of the female reproductive axis is available. This is not the case for men for whom, until now, there is no reliable male reversible method and for whom vasectomy, condom and withdrawal are the only options available. Despite this limited supply, more than one third of all contraceptive methods used worldwide rely on the cooperation of the male partner. Besides developing hormonal approaches to stop sperm production, there may be attractive approaches that will interfere with sperm functions rather than production...
2018: Basic and Clinical Andrology
https://www.readbyqxmd.com/read/30397480/male-reproductive-health-statement-xiiith-international-symposium-on-spermatology-may-9th-12th-2018-stockholm-sweden
#2
Hagai Levine, Hideo Mohri, Anders Ekbom, Liliana Ramos, Geoff Parker, Eduardo Roldan, Luca Jovine, Sabine Koelle, Anna Lindstrand, Simone Immler, Sharon Mortimer, David Mortimer, Gerhard van der Horst, Sumio Ishijima, Natalie Aneck-Hahn, Elisabetta Baldi, Roelof Menkveld, Susan A Rothmann, Aleksander Giwercman, Yvonne Giwercman, Mats Holmberg, Ulrik Kvist, Lars Björndahl, Rebecka Holmberg, Stefan Arver, John Flanagan, Joël R Drevet
On the occasion of the XIIIth International Symposium on Spermatology held from 9 to 13 May 2018 in Stockholm (Sweden), participants (guest speakers and audience) collectively felt the need to make a public statement on the general issue of male reproductive health. Our intention is to raise awareness of what we believe is a neglected area of research despite alarming situations around the world. The disclosure strategy desired by the co-authors is to bring it to the attention of the greatest number partly by considering co-publication in the various periodicals dealing with Reproductive Biology and Andrology...
2018: Basic and Clinical Andrology
https://www.readbyqxmd.com/read/30186608/gel-electrophoresis-of-human-sperm-a-simple-method-for-evaluating-sperm-protein-quality
#3
Jumeau Fanny, Sigala Julien, Fernandez-Gomez Francisco-Jose, Eddarkaoui Sabiha, Duban-Deweer Sophie, Buée Luc, Béhal Hélène, Sergeant Nicolas, Mitchell Valérie
Background: The limitations of conventional sperm analyses have highlighted the need for additional means of evaluating sperm quality. Methods: In a study of a cohort of 245 men with known conventional sperm parameters, one-dimensional PAGE was used to monitor protein content and quality in samples from individual ejaculates. Results: The sperm protein content varied markedly from sample to another, especially in the high-molecular-weight range...
2018: Basic and Clinical Andrology
https://www.readbyqxmd.com/read/30123508/sperm-cryopreservation-incidence-in-men-with-testicular-cancer-towards-a-stabilization-in-testicular-cancer-incidence-results-from-the-cecos-network
#4
Marie Walschaerts, Louis Bujan, Cécile Chouquet, Valentine Rossi, Jean-Claude Juillard, Patrick Thonneau
Background: Testicular cancer (TC) represents 1% of all new male cancer cases but remains the most frequent cancer in adolescents and young adults in industrialized countries. In this study, we assessed time trends in use of sperm cryopreservation by men with TC from 1990 to 2013 in France. Methods: We collected data from patients diagnosed with TC who underwent sperm cryopreservation in the French national network of sperm banks. Trends in the incidence of sperm cryopreservation were estimated through two statistical models: the commonly used Poisson regression model and the Verhulst model...
2018: Basic and Clinical Andrology
https://www.readbyqxmd.com/read/30026950/a-change-from-gonadotropin-releasing-hormone-antagonist-to-gonadotropin-releasing-hormone-agonist-therapy-does-not-affect-the-oncological-outcomes-in-hormone-sensitive-prostate-cancer
#5
Jumpei Asakawa, Taro Iguchi, Satoshi Tamada, Sayaka Yasuda, Noriko Ninomiya, Minoru Kato, Takeshi Yamasaki, Tetusji Ohmachi, Tatsuya Nakatani
Background: The aim of our retrospective study was to evaluate the 5-year survival and time to castration resistant prostate cancer in patients with hormone sensitive prostate cancer treated with the gonadotropin releasing hormone antagonist, degarelix. Another aim was to evaluate the effects of changing the treatment from degarelix to a gonadotropin releasing hormone agonist after achieving stable disease control, on the clinical and oncological outcomes. Results: Our analysis was based on the data of 108 patients with prostate cancer who were treated with degarelix...
2018: Basic and Clinical Andrology
https://www.readbyqxmd.com/read/30002831/testicular-microlithiasis-and-testicular-tumor-a-review-of-the-literature
#6
Louis Leblanc, François Lagrange, Pierre Lecoanet, Baptiste Marçon, Pascal Eschwege, Jacques Hubert
Introduction: There are numerous scientific publications on testicular microlithiasis (TML) detected during ultrasound (US) examination. We wished to update the data. Methods: PubMed was used to identify original articles published between 1998 and May 2017 describing the association between TML and testicular tumor. Studies were only included if TML was diagnosed by US. Studies were then classified into subgroups according to the following criteria: asymptomatic, symptomatic, infertility, cryptorchidism, family or personal history of testicular cancer, and "no given reason for US"...
2018: Basic and Clinical Andrology
https://www.readbyqxmd.com/read/29946470/the-involvement-of-the-nuclear-lamina-in-human-and-rodent-spermiogenesis-a-systematic-review
#7
Marine Paci, Razan Elkhatib, Guy Longepied, Patrice Bourgeois, Pierre F Ray, Nicolas Levy, Michael J Mitchell, Catherine Metzler-Guillemain
The nuclear lamina (NL) is a filamentous protein meshwork, composed essentially of lamins, situated between the inner nuclear membrane and the chromatin. The NL is a component of the nuclear envelope, interacts with a wide range of proteins and is required for normal nuclear structure and physiological development. During spermiogenesis the spermatid nucleus is elongated, and dramatically reduced in size with protamines replacing histones to produce a highly compacted chromatin. There is mounting evidence from studies in human and rodent, that the NL plays an important role in mammalian spermatid differentiation during spermiogenesis...
2018: Basic and Clinical Andrology
https://www.readbyqxmd.com/read/29881623/understanding-the-seminal-plasma-proteome-and-its-role-in-male-fertility
#8
Mariana Camargo, Paula Intasqui, Ricardo Pimenta Bertolla
Seminal plasma is a complex fluid comprised of secretions from the seminal vesicles, the prostate, bulbourethral glands and from the seminiferous tubule lumen / epididymides / vasa deferentia . While it has been established that seminal plasma serves not only as a medium to carry, protect, and nourish sperm after ejaculation up to fertilization, but also as a functional modulator of sperm function, there is still a need to properly characterize the molecular make-up of seminal plasma in fertile men, and to understand how this is altered in different causes of male infertility...
2018: Basic and Clinical Andrology
https://www.readbyqxmd.com/read/29760927/is-sperm-fish-analysis-still-useful-for-robertsonian-translocations-meiotic-analysis-for-23-patients-and-review-of-the-literature
#9
Anna Lamotte, Guillaume Martinez, Françoise Devillard, Jean-Pascal Hograindleur, Véronique Satre, Charles Coutton, Radu Harbuz, Florence Amblard, James Lespinasse, Mehdi Benchaib, Julien Bessonnat, Sophie Brouillet, Sylviane Hennebicq
Background: Robertsonian translocations (RobT) are common structural chromosome rearrangements where carriers display a majority of chromosomally balanced spermatozoa from alternate segregation mode. According to some monotony observed in the rates of balanced segregation, is sperm FISH analysis obsolete for RobT carriers? Methods: Retrospective cohort research study on 23 patients analyzed in our center from 2003 to 2017 and compared to the data of 187 patients in literature from 1983 to 2017...
2018: Basic and Clinical Andrology
https://www.readbyqxmd.com/read/29619224/sperm-aneuploidy-and-dna-fragmentation-in-unexplained-recurrent-pregnancy-loss-a-multicenter-case-control-study
#10
Camille Esquerré-Lamare, Marie Walschaerts, Lucie Chansel Debordeaux, Jessika Moreau, Florence Bretelle, François Isus, Gilles Karsenty, Laetitia Monteil, Jeanne Perrin, Aline Papaxanthos-Roche, Louis Bujan
Background: Recurrent pregnancy loss (RPL) is defined as the loss of at least three pregnancies in the first trimester. Although the most common cause is embryo aneuploidy, and despite female checkup and couple karyotyping, in about 50% of cases RPL remain unexplained. Male implication has little been investigated and results are discordant. In this context, we conducted a multi-center prospective case-control study to investigate male gamete implication in unexplained RPL. Methods: A total of 33 cases and 27 controls were included from three university hospitals...
2018: Basic and Clinical Andrology
https://www.readbyqxmd.com/read/29556396/longer-trinucleotide-repeats-of-androgen-receptor-are-associated-with-higher-testosterone-and-low-oxytocin-levels-in-diabetic-premature-ejaculatory-dysfunction-patients
#11
Haroon Latif Khan, Shahzad Bhatti, Sana Abbas, Yousaf Latif Khan, Rosa Maria Marquez Gonzalez, Muhammad Aslamkhan, Gerardo Rodriguez Gonzalez, Hikmet Hakan Aydin
Background: Despite its worldwide high occurrence, the obscurity regarding the description, epidemiology and management of premature ejaculation remains provocative. It is well established that male premature ejaculatory dysfunction is an increasing problem due to spontaneous ejaculation across a variety of general and clinical subjects. The main goal of this study was to determine the relationships between trinucleotide repeats of the androgen receptor (AR), sex steroids, and pituitary hormones with sexual function in men with type 2 diabetes mellitus (DM) and reported with acquired premature ejaculation (PE)...
2018: Basic and Clinical Andrology
https://www.readbyqxmd.com/read/29456864/curative-gnrha-treatment-has-an-unexpected-repressive-effect-on-sertoli-cell-specific-genes
#12
Katharina Gegenschatz-Schmid, Gilvydas Verkauskas, Philippe Demougin, Vytautas Bilius, Darius Dasevicius, Michael B Stadler, Faruk Hadziselimovic
Background: Follicle stimulating hormone and testosterone stimulate Sertoli cells to support germ cell function and differentiation. During mini-puberty, when gonadotropin (GnRH) stimulates increases in plasma luteinizing hormone (LH) and testosterone levels, gonocytes are transformed into Ad spermatogonia. In cryptorchidism, impaired gonadotropin secretion during mini-puberty results in insufficient LH and testosterone secretion, impaired gonocyte transition to Ad spermatogonia, and perturbed Sertoli cell proliferation...
2018: Basic and Clinical Andrology
https://www.readbyqxmd.com/read/29416867/onco-testicular-sperm-extraction-onco-tese-from-a-single-testis-with-metachronous-bilateral-testicular-cancer-a-case-report
#13
Itsuto Hamano, Shingo Hatakeyama, Rika Nakamura, Rie Fukuhara, Daisuke Noro, Hiroko Seino, Takahiro Yoneyama, Yasuhiro Hashimoto, Takuya Koie, Yoshihito Yokoyama, Chikara Ohyama
Background: Although oncologic testicular sperm extraction (onco-TESE) has been increasingly practiced, the evidence of onco-TESE performed in patients with testicular cancer is insufficient. Furthermore, in bilateral testicular cancer, accounting for 0.5%-1% of testicular cancers, onco-TESE is more challenging and has been insufficiently reported. Case presentation: Here we report the case of a 25-year-old man who underwent onco-TESE from his residual single testis with a nonseminomatous germ cell tumor that occurred 5 years after orchiectomy of the contralateral testis...
2018: Basic and Clinical Andrology
https://www.readbyqxmd.com/read/29163975/on-the-descent-of-the-epididymo-testicular-unit-cryptorchidism-and-prevention-of-infertility
#14
REVIEW
Faruk Hadziselimovic
This comprehensive review provides in-depth coverage of progress made in understanding the molecular mechanisms underlying cryptorchidism, a frequent pathology first described in about 1786 by John Hunter. The first part focuses on the physiology, embryology, and histology of epididymo-testicular descent. In the last 20 years epididymo-testicular descent has become the victim of schematic drawings with an unjustified rejection of valid histological data. This part also includes discussion on the roles of gonadotropin-releasing hormone, fibroblast growth factors, Müllerian inhibiting substance, androgens, inhibin B, and insulin-like 3 in epididymo-testicular descent...
2017: Basic and Clinical Andrology
https://www.readbyqxmd.com/read/29123667/paternal-obesity-how-bad-is-it-for-sperm-quality-and-progeny-health
#15
Georges Raad, Mira Hazzouri, Silvia Bottini, Michele Trabucchi, Joseph Azoury, Valérie Grandjean
There is substantial evidence that paternal obesity is associated not only with an increased incidence of infertility, but also with an increased risk of metabolic disturbance in adult offspring. Apparently, several mechanisms may contribute to the sperm quality alterations associated with paternal obesity, such as physiological/hormonal alterations, oxidative stress, and epigenetic alterations. Along these lines, modifications of hormonal profiles namely reduced androgen levels and elevated estrogen levels, were found associated with lower sperm concentration and seminal volume...
2017: Basic and Clinical Andrology
https://www.readbyqxmd.com/read/29046808/occurrence-and-reproductive-roles-of-hormones-in-seminal-plasma
#16
Jana Vitku, Lucie Kolatorova, Richard Hampl
Only 2-5% of seminal fluid is composed of spermatozoa, while the rest is seminal plasma. The seminal plasma is a rich cocktail of organic and inorganic compounds including hormones, serving as a source of nutrients for sperm development and maturation, protecting them from infection and enabling them to overcome the immunological and chemical environment of the female reproductive tract. In this review, a survey of the hormones found in human seminal plasma, with particular emphasis on reproductive hormones is provided...
2017: Basic and Clinical Andrology
https://www.readbyqxmd.com/read/29021901/icsi-diagnostic-a-way-to-prevent-total-fertilization-failure-after-4-unsuccessful-iui
#17
Arnaud Larbuisson, Dominique Raick, Stephanie Demelenne, Annick Delvigne
BACKGROUND: The aim of this retrospective study is to investigate the relevance of dividing oocytes and using some for traditional in vitro fertilization (IVF) and others for intracytoplasmic sperm injection (ICSI) as of the first IVF cycle in patients with unexplained infertility who have undergone 4 intrauterine insemination (IUI) cycles which produced no pregnancies. METHODS: This retrospective study includes patients with unexplained infertility who have failed to become pregnant, after 4 IUI, despite normal semen parameters after sperm capacitation...
2017: Basic and Clinical Andrology
https://www.readbyqxmd.com/read/28904798/patterns-of-residual-hiv-1-rna-shedding-in-the-seminal-plasma-of-patients-on-effective-antiretroviral-therapy
#18
Christophe Pasquier, Marie Walschaerts, Stéphanie Raymond, Nathalie Moinard, Karine Saune, Myriam Daudin, Jacques Izopet, Louis Bujan
BACKGROUND: More and more HIV-1-infected men on effective antiretroviral treatment (ART) have unprotected sex in order to procreate. The main factor influencing transmission is seminal HIV shedding. While the risk of HIV transmission is very low, it is difficult to assess in individuals. Nevertheless, it should be quantified. RESULTS: We retrospectively analysed seminal plasma HIV-1 shedding by 362 treated HIV-infected men attending a medically assisted reproduction centre (1998-2013) in order to determine its frequency, the impact of the antiretroviral regimen on HIV shedding, and to identify shedding patterns...
2017: Basic and Clinical Andrology
https://www.readbyqxmd.com/read/28835845/sleep-disturbances-and-semen-quality-in-an-italian-cross-sectional-study
#19
Paola Viganò, Francesca Chiaffarino, Viviana Bonzi, Andrea Salonia, Elena Ricci, Enrico Papaleo, Paola Agnese Mauri, Fabio Parazzini
INTRODUCTION: In order to obtain information about the relationship between sleep disturbances and sperm parameters, we analyzed data from a study conducted in a Italian Fertility Clinic, in men of couples seeking help for infertility. PATIENTS AND METHODS: Male partners with or without a medical history of reproductive organ diseases (cryptorchidism, varicocele, orchitis, testicular torsion) were eligible for the study. There were 382 men evaluated from May 2014 to November 2016, all of whom completed a self-administered questionnaire on general lifestyle habits...
2017: Basic and Clinical Andrology
https://www.readbyqxmd.com/read/28794880/relationship-between-semenogelins-bound-to-human-sperm-and-other-semen-parameters-and-pregnancy-outcomes
#20
Kazumitsu Yamasaki, Kaoru Yoshida, Miki Yoshiike, Kazuhiko Shimada, Hiroyuki Nishiyama, Satoru Takamizawa, Kaoru Yanagida, Teruaki Iwamoto
BACKGROUND: Semenogelins (SEMGs) are major components of human seminal vesicle secretions. Due to SEMG's sperm-motility inhibitor, a significant negative correlation between sperm motility and the proportion of SEMG-bound spermatozoa (SEMG+) was found in asthenozoospermic patients. SEMGs also show intrinsic inhibitory capability for sperm capacitation; however, studies on actual clinical specimens have not been conducted. METHODS: To reveal the relationship between SEMGs and the fertilizing capacity of sperm from male infertile patients who are not restricted to asthenozoospermia, we measured the proportion of SEMG+ in the spermatozoa of 142 male infertile patients...
2017: Basic and Clinical Andrology
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