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Journal of Oral Biology and Craniofacial Research

Shoeb Kasim Jendi, Abhishek Talathi
Purpose: To evaluate and compare the soft tissue anaesthesia produced by tramadol hydrochloride on gingival tissues in maxilla. Methods: A total of 50 ASA physical status I subjects between 18 and 35 years of age, both male and female were included in the study. Each individual received 0.5 ml of 50 mg tramadol in the soft tissues over maxillary canine tooth as local infiltration on one and 0.5 ml of 20 mg lignocaine on the contralateral side in a double-blinded fashion...
January 2019: Journal of Oral Biology and Craniofacial Research
Akshat Gupta, Vidya Rattan, Sachin Rai
Purpose: Chitosan has been shown to promote wound healing and induce bone formation. The aim of this split-mouth study was to evaluate the effectiveness of chitosan based dressing in wound healing after lower third molar extraction. Method: Asymptomatic symmetrical mandibular third molars were extracted simultaneously in 27 patients and Chitosan dressing was placed into the extraction socket in the test side. Pain scores were recorded on VAS using a 0 to 10 pain score...
January 2019: Journal of Oral Biology and Craniofacial Research
Lucilene Hernandes Ricardo, Renata Falchete do Prado, Yasmin Rodarte Carvalho, Felipe da Silva Peralta, Debora Pallos
The most important microscopic characteristic of Cyclosporine A-induced gingival overgrowth is fibroepithelial hyperplasia. OBJECTIVE: The objective was to investigate the influence of previous exposure to Cyclosporine A over gingival epithelium in experimental periodontitis in rats. METHODS: Twenty Wistar rats with 12 weeks-old were divided into four groups with 5 animals each: Control Group (CG); Cyclosporine Group (CsAG); Ligature group (LG) and Cyclosporine and Ligature Group (CsALG)...
January 2019: Journal of Oral Biology and Craniofacial Research
Raturi Vijay Parshuram, Rajendra Kumar, Madan Lal Brahma Bhatt, Rahul Singh, Devendra Parmar, Jalaj Gaur, Dewesh Kishan, Mandira Saha, Roopali, Pranay Katepogu, Prasad Senthamizh, Tridiv Katiyar
Objectives: The correlation of XRCC-1 Gene Arg194Trp polymorphism with alcohol and tobacco substance user and with loco-regionally progressed squamous cell cancer of the larynx (LSCC) was assessed in this research study. The result of this research study is described herein. Material and methods: A tertiary hospital-based observational case-control research was carried out. DNA segregation and Genotype examination were done from the blood sample of the control group and cases to know the correlation between XRCC-1 gene polymorphism with loco-regionally progressed LSCC and with hazard factors tobacco and alcohol...
January 2019: Journal of Oral Biology and Craniofacial Research
Pilana Vithanage Kalani Shihanika Hettiarachchi, Rasika Manori Jayasinghe, Manil Christopher Fonseka, Ruwan Duminda Jayasinghe, Chinthani Deepthi Nanayakkara
Objective: The objectives of this study were to evaluate the normal radiographic length of the styloid process (SP), prevalence and type of elongation, and angulation of the styloid process in relation to sex and side on digital panoramic radiographs in a Sri Lankan population. Methods: A total of 100 digital panoramic images selected from the database at the Division of Oral Medicine and Radiology, Faculty of Dental Sciences, University of Peradeniya, Sri Lanka were evaluated for the radiological features of the styloid process...
January 2019: Journal of Oral Biology and Craniofacial Research
Vrishti Bansal, Rajan Gupta, Parveen Dahiya, Mukesh Kumar, Japnit Kaur Samlok
Background: Considering the microbial etiology of the periodontal disease, the periodontal therapy aims to control or abolish the pathogenic microbes. The gold standard scaling and root planing procedure has been used since time immemorial but the drawbacks associated with it have led to the development of various adjunctive means. The current study was therefore, performed to comparatively assess the efficacy of local delivery of chlorhexidine and 808-nm diode LASER as an appurtenance to scaling and root planing in patients with chronic periodontitis...
January 2019: Journal of Oral Biology and Craniofacial Research
Azadeh Andisheh-Tadbir, Mohammad Javad Ashraf, Ali Gudarzi, Razieh Zare
Introduction: Glypican-3 (GPC3) is involved in regulation of cell proliferation and morphogenesis. It is abundant in embryonic tissue, but limited in most adult tissues. GPC3 deletion or mutation can disturb the balance between cell apoptosis and proliferation, which may result in tumorigenesis. This study aimed to investigate the GPC3 expression in salivary gland tumors (SGTs) and the adjacent non-neoplastic tissues. Methods: This study reviewed 50 samples of salivary tumors from the archive of Khalili Hospital, Shiraz, Iran, including 17 cases of pleomorphic adenoma (PA), 16 cases of mucoepidermoid carcinoma (MEC), and 17 cases of adenoid cystic carcinoma (ACC); as well as a control group of 23 cases of normal salivary gland tissues...
January 2019: Journal of Oral Biology and Craniofacial Research
Ekarat Phattarataratip, Nicha Kositkittiwanit, Pruch Kajornkiatkul, Pataraporn Yeunyong, Ratanatip Ratanapitak
Objectives: Altered P120 catenin expression has been associated with E-cadherin loss and poor prognosis in several cancers. The objectives of this study were to examine the P120 catenin expression in salivary gland neoplasms in correlation with E-cadherin and assess the relationships between their expression levels and pathologic characteristics. Methods: Fifty-two cases of salivary gland neoplasms, i.e. 25 mucoepidermoid carcinomas (MEC), 13 adenoid cystic carcinomas (ACC), 12 pleomorphic adenomas (PA) and 2 polymorphous adenocarcinomas (PAC) were included...
January 2019: Journal of Oral Biology and Craniofacial Research
Maj Raj Kumar Maurya, Col Prasanna Kumar, Lt Col Mohit Sharma, Lt Col Karan Nehra, Harpreet Singh, Prabhat Kumar Chaudhari
Aim: This retrospective study was performed to rule out any jeopardizing effect of extraction therapy of four first premolars on airway at any level of its anatomic course. Materials and methods: Lateral cephalograms of 50 adolescent patients divided into two groups of 25 each, based on orthodontic treatment by first premolar extraction as group I and without extraction as group II, were selected for the study. 13 angular and 11 linear measurements were compared pre-and post-treatment via statistical analyses using SPSS (Version 17...
January 2019: Journal of Oral Biology and Craniofacial Research
Zohreh Jaafari-Ashkavandi, Fatemeh Mehranmehr, Elham Roosta
Background: MCM3 is a marker of proliferation that has been used as a diagnostic or prognostic marker in many pathologic lesions. Purpose: The purpose of this study is to investigate the proliferative activity of dentigerous cysts, odontogenic keratocyst and ameloblastoma using minichromosome maintenance 3 (MCM3) and compare it with Ki-67 proliferation marker. Methods: In this cross-sectional study, 40 cases including 11 cases of dentigerous cyst, 14 odontogenic keratocyst, and 15 ameloblastoma were included...
January 2019: Journal of Oral Biology and Craniofacial Research
Ankita Sahni, Shweta Rehani, Priyanka Kardam, Sneha Sethi, Rashmi Kumari, Yulia Mathias
Background: Mucins are glycoproteins that act as a selective molecular barrier and its alterations usually accompany the carcinogenesis. Aim: To evaluate the transition of mucins in the grades of oral epithelial dysplasia (OED) and oral squamous cell carcinoma (OSCC) using histochemical stains. Materials & Method: A total of 66 samples of variable grades of OED and OSCC and each section was stained with PAS, Alcian blue- PAS (AB-PAS) and Aldehyde fuschin - Alcian blue (AF-AB)...
January 2019: Journal of Oral Biology and Craniofacial Research
N M Al-Namnam, F Hariri, M K Thong, Z A Rahman
Crouzon syndrome exhibits considerable phenotypic heterogeneity, in the aetiology of which genetics play an important role. FGFR2 mediates extracellular signals into cells and the mutations in the FGFR2 gene cause this syndrome occurrence. Activated FGFs/FGFR2 signaling disrupts the balance of differentiation, cell proliferation, and apoptosis via its downstream signal pathways. However, very little is known about the cellular and molecular factors leading to severity of this phenotype. Revealing the molecular pathology of craniosynostosis will be a great value for genetic counselling, diagnosis, prognosis and early intervention programs...
January 2019: Journal of Oral Biology and Craniofacial Research
Fahad M Samadi, Shaista Suhail, Manjari Sonam, Neeta Sharma, Shruti Singh, Sushil Gupta, Ashwini Dobhal, Harsha Pradhan
Candida carriage was reported to be common in oral cancer patients, with C. albicans being the predominant species. The prevalence of diseases caused by Candida species have been found to increase in recent years. AIM: The aim of our study was to find the antifungal activities at MIC of selected fifteen plant leaves extracts prepared in three different solutions (methanol and ethanol) against the opportunistic pathogen Candida albicans isolated from oral cavity infections. It may also help the clinician to treat the patient not only for the particular lesion that is present, but also to treat the infection by Candida albicans so as to reduce its potential to malignant transformation...
January 2019: Journal of Oral Biology and Craniofacial Research
Sachidanand Giri, Anurag Tripathi, Ranjitkumar Patil, Vikram Khanna, Vandana Singh
No abstract text is available yet for this article.
January 2019: Journal of Oral Biology and Craniofacial Research
Archana Gupta, Anurag Tripathi, Ranjitkumar Patil, Vijay Kumar, Vikram Khanna, Vandana Singh
Objective: The purpose of this study was to evaluate salivary and serum basic fibroblast growth factor (bFGF) level in OSCC patients to provide a reliable biomarker for the early detection, monitoring, and prognosis of OSCC patients. Materials and methods: The study enrolled 90 subjects, equally grouped as recently diagnosed & untreated OSCC patients (Group I), treated OSCC without any recurrence (Group II) & as control (Group III). Enzyme-linked immunosorbent assay was employed to measure bFGF concentrations in saliva and serum samples of all three groups...
January 2019: Journal of Oral Biology and Craniofacial Research
Rohini Negi, Rajan Gupta, Parveen Dahiya, Mukesh Kumar, Vrishti Bansal, Japnit Kaur Samlok
Objective: Pigmentation of the gingiva plays a negative role in an otherwise acceptable "smile window". In the present world, people are more concerned about their aesthetics. Several techniques have been employed such as scalpel surgery, electrosurgery, cryosurgery, chemical agents, abrasion and LASER method for the removal of melanin hyper-pigmentation. The present study is aimed at comparing the efficacy of LASER and soft tissue trimmer for gingival depigmentation. Methods: A randomized split-mouth study was conducted for twenty patients with gingival pigmentation...
January 2019: Journal of Oral Biology and Craniofacial Research
Preeti Dhawan, Aditi Singh, Anubha Agarwal, Himanshu Aeran
Aim: To assess validity and reliability of Hindi version of Child Oral impact on daily performances (C-OIDP) index among school children in North India. Material and methodology: Descriptive cross sectional study was conducted amongst 250, 11-12 year old school children in primary schools of Rishikesh, Uttarakhand, India. The study was done in two phases: first phase included assessment of Psychometric and linguistic properties of hindi version of C-OIDP index which was then pilot tested on study subjects...
January 2019: Journal of Oral Biology and Craniofacial Research
P Divya Kumari, A Veena Shetty, Shahnawaz Khijmatgar, Avidyuti Chowdhury, Edward Lynch, Chitta R Chowdhury
Background: The mutagenicity potential of a new atraumatic restorative treatment (ART) material against Salmonella typhimurium without metabolic activity using the Ames test (genotoxicity) was carried out. Methods and materials: The potential mutagenicity of new atraumatic restorative treatment materials (ART-I and ART-II) was analyzed using the Ames test. The materials were eluted in dimethyl sulphoxide, 0.9% NaCl solution and sterilized de-ionized water and the aliquots were used after an incubation period of 24 h at 37 °C...
January 2019: Journal of Oral Biology and Craniofacial Research
Ali Akbar Nagavi-Alhoseiny, Maryam Torshabi, Morteza Rasoulianboroujeni, Lobat Tayebi, Fahimeh Sadat Tabatabaei
Purpose: In this work, the effects of sodium chloride (NaCl) on gene expression of planktonic Streptococcus mutans cells are investigated. Also assessed are the effects of NaCl on zeta potential of sound and demineralized dentin. Methods: The relative level of glucosyltransferase B ( gtfB ), gtfC and gtfD transcription of S. mutans in the presence of NaCl was evaluated by quantitative polymerase chain reaction (qPCR). The osmolality of varying salt (NaCl) concentrations and their influence on the zeta potential of sound and demineralized dentin was investigated as well...
January 2019: Journal of Oral Biology and Craniofacial Research
Rajiv M Borle, Anendd Jadhav, Nitin Bhola, Pawan Hingnikar, Prafulla Gaikwad
Purpose: An accurate understanding of the anatomy, identification and preservation of facial nerve is critical in performing successful functional parotidectomies. The current literature is replete with inconsistencies of various landmarks when used alone for identification of facial nerve trunk (FNT). The purpose of the paper is to introduce a new anatomical triangle, Borle's triangle (BT) for safer and reliable operative identification of FNT during parotodectomies. Patients and methods: Between Aug 2014 and Dec 2017, twelve patients who reported with unilateral disease of the parotid gland with intact facial nerve function who underwent superficial or complete parotidecomies were included in the study...
January 2019: Journal of Oral Biology and Craniofacial Research
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