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Journal of Bone Oncology

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https://www.readbyqxmd.com/read/29850399/no-consensus-on-implant-choice-for-oligometastatic-disease-of-the-femoral-head-and-neck
#1
Taylor J Reif, Patrick K Strotman, Stephanie A Kliethermes, Benjamin J Miller, Lukas M Nystrom
Objectives: Metastatic disease involving the femoral head and neck is often treated with a hemiarthroplasty or total hip arthroplasty (THA) to prevent pathologic fracture but there are no outcome studies demonstrating superiority of one option over the other. Methods: This investigation was designed as a survey of the current members of the Musculoskeletal Tumor Society (MSTS). The survey contained seven clinical vignettes with identical imaging of a pathologic lesion of the femoral head and neck...
September 2018: Journal of Bone Oncology
https://www.readbyqxmd.com/read/29850398/small-animal-models-for-the-study-of-bone-sarcoma-pathogenesis-characteristics-therapeutic-interests-and-limitations
#2
REVIEW
Camille Jacques, Nathalie Renema, Frederic Lezot, Benjamin Ory, Carl R Walkley, Agi E Grigoriadis, Dominique Heymann
Osteosarcoma, Ewing sarcoma and chondrosarcoma are the three main entities of bone sarcoma which collectively encompass more than 50 heterogeneous entities of rare malignancies. In contrast to osteosarcoma and Ewing sarcoma which mainly affect adolescents and young adults and exhibit a high propensity to metastasise to the lungs, chondrosarcoma is more frequently observed after 40 years of age and is characterised by a high frequency of local recurrence. The combination of chemotherapy, surgical resection and radiotherapy has contributed to an improved outcome for these patients...
September 2018: Journal of Bone Oncology
https://www.readbyqxmd.com/read/29556454/surgical-thyroparathyroidectomy-prevents-progression-of-5tgm1-murine-multiple-myeloma-in-vivo
#3
REVIEW
Maurizio Zangari, Hanna Yoo, Ik Jae Shin, Donghoon Yoon, Larry J Suva
The 5TGM1 multiple myeloma transplanted C57BL6/KaLwRij model recapitulates many disease features including monoclonal paraprotein production as well as the development of osteolytic bone lesions. Since a significant association between serum parathyroid hormone PTH variations, bone anabolism and myeloma progression in patients receiving proteasome inhibitors exists, this study investigated the effect of the PTH axis on murine myeloma development in vivo . C57BL6/KaLwRij myeloma-bearing mice underwent thyroparathyroidectomy (TPTX) before and after 5TGM1 cell transplantation...
September 2018: Journal of Bone Oncology
https://www.readbyqxmd.com/read/29892522/blockade-of-ccl2-enhances-immunotherapeutic-effect-of-anti-pd1-in-lung-cancer
#4
Yue Wang, Xiaokai Zhang, Liangliang Yang, Jinru Xue, Guangrui Hu
Myeloid derived suppressor cells (MDSC) play a pivotal role in tumor immune evasion and MDSC levels increased in patients with cancer. Studies confirmed the associations between MDSC and various cytokines in the peripheral blood. However, little is known about the association between parenchymal MDSC subsets and cytokines, or the mechanism drawing MDSC into tumor parenchyma. This study was to analyze the correlation between MDSC subsets and CCL2 level in lung cancer model. G-MDSC and M-MDSC from the blood and parenchyma were analyzed by flow cytometry and western blot in the lung tumor model...
June 2018: Journal of Bone Oncology
https://www.readbyqxmd.com/read/29892521/analysis-of-curative-effect-of-i-125-implantation-combined-with-radiofrequency-ablation-in-treating-bone-metastases
#5
Qizhou Zhang, Kunyao Zhang, Bing Xie, Yimin Ren, Guoliang Li, Liping Zhang, Aijing Wang, Yang Li
The aims of this study were to investigate the clinical effects of I125 implantation combined with radiofrequency ablation in treating bone metastases (BM) and analyze its clinical application so as to provide better treatment protocols for the treatment of BM. A total of 63 BM patients were randomly divided into the I125 implantation group (CON, treated with I125 seeds alone, 33 patients) and the combination group (I125 -MA, 30 patients) to compare the clinical efficacy and adverse effects. After treatment, the clinical efficacy of Group I125 -MA was significantly better than Group CON, and the quality of life was improved significantly (P< 0...
June 2018: Journal of Bone Oncology
https://www.readbyqxmd.com/read/29892520/telangiectatic-osteosarcoma-outcome-analyses-and-a-diagnostic-model-for-differentiation-from-aneurysmal-bone-cyst
#6
Jun-Qiang Yin, Yi-Wei Fu, Xian-Biao Xie, Xiao-Yu Cheng, Xiao-Yu Yang, Wei-Hai Liu, Jian Tu, Zhen-Hua Gao, Jing-Nan Shen
Background and purpose: Telangiectatic osteosarcoma (TOS), a rare variant of osteosarcoma, may be easily misdiagnosed as aneurysmal bone cyst (ABC). The aims of this study were to investigate the diagnostic and prognostic factors of TOS by reviewing our experience with TOS and to develop a diagnostic model that may distinguish TOS from ABC. Materials and methods: We identified 51 cases of TOS treated at the First Affiliated Hospital of Sun Yat-Sen University from March 2001 to January 2016 and reviewed their records, imaging information and pathological studies...
June 2018: Journal of Bone Oncology
https://www.readbyqxmd.com/read/29892519/bone-targeted-agent-treatment-patterns-and-the-impact-of-bone-metastases-on-patients-with-advanced-breast-cancer-in-real-world-practice-in-six-european-countries
#7
Roger von Moos, Jean-Jacques Body, Alex Rider, Jonathan de Courcy, Debajyoti Bhowmik, Francesca Gatta, Guy Hechmati, Yi Qian
Background: Bone metastases (BMs) are common in patients with breast cancer and can lead to skeletal-related events (SREs), which are associated with increased pain and reduced quality of life (QoL). Bone-targeted agents (BTAs), like zoledronic acid and denosumab, reduce the incidence of SREs and delay progression of bone pain. Materials and methods: We evaluated the management of BMs and pain in six European countries (Belgium, France, Germany, Italy, Spain, and UK) using the Adelphi Breast Cancer Disease Specific Programme, which included a physician survey and patient-reported outcomes (PROs) to assess the impact of BMs on pain and QoL...
June 2018: Journal of Bone Oncology
https://www.readbyqxmd.com/read/29552462/role-of-18f-fluorodeoxyglucose-positron-emission-tomography-computed-tomography-in-predicting-pathological-response-to-preoperative-super-selective-intra-arterial-chemoradiotherapy-for-advanced-squamous-cell-carcinoma-of-the-mandible
#8
Maiko Shibasaki, Toshinori Iwai, Senri Oguri, Toshiyuki Koizumi, Makoto Hirota, Kenji Mitsudo, Yukihiko Ozawa, Iwai Tohnai
Introduction: Although chemoradiotherapy (CRT) for oral squamous cell carcinoma (SCC) has been shown to preserve organ function and improve cosmetic results, site-specific data, especially mandible, are limited. The aim of this study was to evaluate the predictability of 18F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) on response to super-selective intra-arterial CRT for advanced SCC of the mandible. Methods: Fifteen patients with advanced SCC of the mandible underwent super-selective intra-arterial CRT followed by radical resection...
June 2018: Journal of Bone Oncology
https://www.readbyqxmd.com/read/29520337/long-non-coding-rna-anril-is-associated-with-a-poor-prognosis-of-osteosarcoma-and-promotes-tumorigenesis-via-pi3k-akt-pathway
#9
Guangyang Yu, Gang Liu, Dongtang Yuan, Jian Dai, Yin Cui, Xiaoming Tang
Aim: Increasing evidence has shown that long noncoding RNAs (lncRNAs) ANRIL may function as oncogenes in various types of malignancies. However, there is still a lack of knowledge concerning its role in osteosarcoma (OS). In this study, we aimed to investigate the influence of ANRIL on cell proliferation and invasion of OS and to determine its association with clinicopathological features of the patients. Methods: The tumor specimens and the adjacent normal tissues were collected from 57 OS patients and the expression level of ANRIL was quantified by RT-qPCR...
June 2018: Journal of Bone Oncology
https://www.readbyqxmd.com/read/29511626/incidence-risk-factors-and-prognostic-characteristics-of-bone-metastases-and-skeletal-related-events-sres-in-breast-cancer-patients-a-systematic-review-of-the-real-world-data
#10
REVIEW
Hongwei Zhang, Wei Zhu, Ewelina Biskup, Weige Yang, Ziang Yang, Hong Wang, Xiaochun Qiu, Chengjiao Zhang, Guangxia Hu, Guangfu Hu
Purpose: The aim was to systematically extrapolate the occurrence, risk factors, prognostic characteristics, management and outcome of bone metastases (BM) and skeletal related events (SREs) of breast cancer survivors in the real world clinical setting. Methods: A systematic literature search of PubMed, Web of Science, EMBASE OvidSP and EBSCO Academic Search Complete was conducted. Published prospective and retrospective papers investigating BM and SREs in breast cancer patients in non-trial settings were identified and systematically reviewed...
June 2018: Journal of Bone Oncology
https://www.readbyqxmd.com/read/29321966/small-interfering-rna-mediated-silencing-of-g-protein-coupled-receptor-137-inhibits-growth-of-osteosarcoma-cells
#11
Hao Li, Xiaodong Fu, Yingjian Gao, Xiaomiao Li, Yi Shen, Weili Wang
Purpose: Osteosarcoma is the most widespread primary carcinoma in bones. Osteosarcoma cells are highly metastatic and frequently develop resistance to chemotherapy making this disease harder to treat. This identifies an urgent need of novel therapeutic strategies for osteosarcoma. G-Protein-coupled receptor 137 (GPR137) is involved in several human cancers and may be a novel therapeutic target. Methods: The expression of GPR137 was assessed in one osteoblast and three human osteosarcoma cell lines via the quantitative real-time polymerase chain reaction and western blot assays...
June 2018: Journal of Bone Oncology
https://www.readbyqxmd.com/read/29577024/healthcare-resource-utilization-associated-with-radiation-to-bone-across-eight-european-countries-results-from-a-retrospective-study
#12
Roger von Moos, Jean-Jacques Body, Oliver Guenther, Evangelos Terpos, Yves Pascal Acklin, Jindrich Finek, João Pereira, Nikos Maniadakis, Guy Hechmati, Susan Talbot, Harm Sleeboom
Background: Bone metastases and lytic lesions due to multiple myeloma are common in advanced cancer and can lead to debilitating complications (skeletal-related events [SREs]), including requirement for radiation to bone. Despite the high frequency of radiation to bone in patients with metastatic bone disease, our knowledge of associated healthcare resource utilization (HRU) is limited. Methods: This retrospective study estimated HRU following radiation to bone in Austria, the Czech Republic, Finland, Greece, Poland, Portugal, Sweden and Switzerland...
March 2018: Journal of Bone Oncology
https://www.readbyqxmd.com/read/29321965/prognostic-score-for-life-expectancy-evaluation-of-lung-cancer-patients-after-bone-metastasis
#13
Dumnoensun Pruksakorn, Areerak Phanphaisarn, Jongkolnee Settakorn, Urarat Arpornchayanon, Apichat Tantraworasin, Parunya Chaiyawat, Jeerawan Klangjorhor, Pimpisa Teeyakasem
Background: This study identifies the overall survival status of lung cancer patients with bone metastasis and metastasis patterns. Poor prognostic factors were identified to develop a scoring system for estimating survival period after bone metastasis. Methods: A retrospective cohort analysis was performed at Chiang Mai University for the period January 1, 2006 and December 31, 2013. Time-to-event analysis was performed to estimate survival rate. The primary end point was death related to lung cancer...
March 2018: Journal of Bone Oncology
https://www.readbyqxmd.com/read/29296558/advances-in-limb-salvage-treatment-of-osteosarcoma
#14
REVIEW
Yichun Yang, Lei Han, Zewei He, Xiaojuan Li, Suping Yang, Jifei Yang, Ya Zhang, Dongqi Li, Yihaho Yang, Zuozhang Yang
Osteosarcoma is the most common primary malignant bone tumor; its standard treatment includes neoadjuvant chemotherapy combined with surgery. Neoadjuvant chemotherapy has significantly improved the 5-year survival and limb salvage rates in osteosarcoma since the 1870s. The survival rate of patients with limb salvage was not inferior to that of amputees, and therefore, limb salvage has become the main surgical option for patients with osteosarcoma. The 5-year survival rate for osteosarcoma has plateaued. However, new advances in limb salvage therapy in osteosarcoma, including adjuvant chemotherapy, ablation techniques, bone transport techniques, and computer navigation techniques, are now available...
March 2018: Journal of Bone Oncology
https://www.readbyqxmd.com/read/29255669/retrospective-investigation-of-paint-brush-borders-sign-in-association-with-local-recurrence-of-giant-cell-tumor-of-bone-after-intralesional-curettage
#15
Yifeng He, Jun Wang, Weiwei Rui, Juiming Lin, Fei Yuan, Lianjun Du, Ji Zhang, Xiaoyi Ding
No abstract text is available yet for this article.
March 2018: Journal of Bone Oncology
https://www.readbyqxmd.com/read/29204337/effects-on-bone-resorption-markers-of-continuing-pamidronate-or-switching-to-zoledronic-acid-in-patients-with-high-risk-bone-metastases-from-breast-cancer
#16
J F Hilton, M Clemons, G Pond, H Zhao, S Mazzarello, L Vandermeer, C L Addison
Background: Switching patients who remain at high risk of skeletal related events (SREs) despite pamidronate to the more potent bisphosphonate zoledronate, may be an effective treatment strategy. As part of a previously reported clinic study in this setting, we evaluated whether biomarkers for bone resorption, such as Bone-Specific Alkaline Phosphatase (BSAP), bone sialoprotein (BSP), and N-terminal telopeptide (NTX) correlated with subsequent SRE risk. Methods: Breast cancer patients who remained at high risk of SREs despite at least 3 months of q...
March 2018: Journal of Bone Oncology
https://www.readbyqxmd.com/read/29234592/experience-of-total-scapular-excision-for-musculoskeletal-tumor-and-reconstruction-in-eastern-asian-countries
#17
Katsuhiro Hayashi, Xiaohui Niu, Xiaodong Tang, Vivek Ajit Singh, Apichat Asavamongkolkul, Akira Kawai, Norio Yamamoto, Toshiharu Shirai, Akihiko Takeuchi, Hiroaki Kimura, Shinji Miwa, Hiroyuki Tsuchiya
Total scapulectomy and reconstruction has been performed for scapular tumor, however, most of the reconstruction methods have resulted in poor functional outcomes and there is still room for improvement. Most of the reports of reconstruction after scapulectomy are from a single institution. In the present study, we investigated functional outcomes after total scapulectomy in a multicenter study in The Eastern Asian Musculoskeletal Oncology Group (EAMOG). Thirty-three patients who underwent total scapulectomy were registered at EAMOG affiliated hospitals...
November 2017: Journal of Bone Oncology
https://www.readbyqxmd.com/read/29234591/reproductive-hormone-analyses-and-effects-of-adjuvant-zoledronic-acid-in-early-breast-cancer-an-azure-big-01-04-sub-study
#18
Caroline Wilson, Samantha Hinsley, Helen Marshall, David Cameron, Richard Bell, David Dodwell, Robert E Coleman
Purpose: Adjuvant bisphosphonates have been shown to improve disease outcomes in early breast cancer in women who are postmenopausal at the start of treatment. We explored the influence of pretreatment serum levels of reproductive hormones in the hypothalamic-pituitary-gonadal (HPG) axis from a subset of patients included in the AZURE trial to investigate their impact on disease recurrence and whether reproductive hormone measurements are of value in selecting patients for treatment with adjuvant zoledronic acid...
November 2017: Journal of Bone Oncology
https://www.readbyqxmd.com/read/29234590/an-integrative-analysis-of-dna-methylation-in-osteosarcoma
#19
Jie Xu, Deng Li, Zhiqing Cai, Yingbin Zhang, Yulin Huang, Baohua Su, Ruofan Ma
Background: The study aimed to analyze aberrantly methylated genes, relevant pathways and transcription factors (TFs) in osteosarcoma (OS) development. Methods: Based on the DNA methylation microarray data GSE36002 that were downloaded from GEO database, the differentially methylated genes in promoter regions were identified between OS and normal samples. Pathway and function enrichment analyses of differentially methylated genes was performed. Subsequently, protein-protein interaction (PPI) network was constructed, followed by identification of cancer-associated differentially methylated genes and significant differentially methylated TFs...
November 2017: Journal of Bone Oncology
https://www.readbyqxmd.com/read/29234589/retrospective-study-of-predictors-of-bone-metastasis-in-colorectal-cancer-patients
#20
Zhenghong, Zihua Zhu, Guoweijian, Zhangning, Caiyunyun, Yingjiangshan, Xiaomi
Background: We explored risk factors for bone metastasis (BMs) in colorectal cancer (CRC) to improve in early diagnosis and follow-up and to reduce bone metastasis. Methods: With a retrospective analysis of 2066 patients with CRC treated in our institution from January 2006 to January 2015, we assessed high-risk variables associated with bone metastasis using univariate and multivariate analyses. Results: Of those subjects studied, 102 patients developed BMs, including 62 of 1014 the rectal cancer patients and 40 of the 1052 colon cancer patients...
November 2017: Journal of Bone Oncology
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