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Journal of Bone Oncology

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https://www.readbyqxmd.com/read/29321966/small-interfering-rna-mediated-silencing-of-g-protein-coupled-receptor-137-inhibits-growth-of-osteosarcoma-cells
#1
Hao Li, Xiaodong Fu, Yingjian Gao, Xiaomiao Li, Yi Shen, Weili Wang
Purpose: Osteosarcoma is the most widespread primary carcinoma in bones. Osteosarcoma cells are highly metastatic and frequently develop resistance to chemotherapy making this disease harder to treat. This identifies an urgent need of novel therapeutic strategies for osteosarcoma. G-Protein-coupled receptor 137 (GPR137) is involved in several human cancers and may be a novel therapeutic target. Methods: The expression of GPR137 was assessed in one osteoblast and three human osteosarcoma cell lines via the quantitative real-time polymerase chain reaction and western blot assays...
June 2018: Journal of Bone Oncology
https://www.readbyqxmd.com/read/29321965/prognostic-score-for-life-expectancy-evaluation-of-lung-cancer-patients-after-bone-metastasis
#2
Dumnoensun Pruksakorn, Areerak Phanphaisarn, Jongkolnee Settakorn, Urarat Arpornchayanon, Apichat Tantraworasin, Parunya Chaiyawat, Jeerawan Klangjorhor, Pimpisa Teeyakasem
Background: This study identifies the overall survival status of lung cancer patients with bone metastasis and metastasis patterns. Poor prognostic factors were identified to develop a scoring system for estimating survival period after bone metastasis. Methods: A retrospective cohort analysis was performed at Chiang Mai University for the period January 1, 2006 and December 31, 2013. Time-to-event analysis was performed to estimate survival rate. The primary end point was death related to lung cancer...
March 2018: Journal of Bone Oncology
https://www.readbyqxmd.com/read/29296558/advances-in-limb-salvage-treatment-of-osteosarcoma
#3
REVIEW
Yichun Yang, Lei Han, Zewei He, Xiaojuan Li, Suping Yang, Jifei Yang, Ya Zhang, Dongqi Li, Yihaho Yang, Zuozhang Yang
Osteosarcoma is the most common primary malignant bone tumor; its standard treatment includes neoadjuvant chemotherapy combined with surgery. Neoadjuvant chemotherapy has significantly improved the 5-year survival and limb salvage rates in osteosarcoma since the 1870s. The survival rate of patients with limb salvage was not inferior to that of amputees, and therefore, limb salvage has become the main surgical option for patients with osteosarcoma. The 5-year survival rate for osteosarcoma has plateaued. However, new advances in limb salvage therapy in osteosarcoma, including adjuvant chemotherapy, ablation techniques, bone transport techniques, and computer navigation techniques, are now available...
March 2018: Journal of Bone Oncology
https://www.readbyqxmd.com/read/29255669/retrospective-investigation-of-paint-brush-borders-sign-in-association-with-local-recurrence-of-giant-cell-tumor-of-bone-after-intralesional-curettage
#4
Yifeng He, Jun Wang, Weiwei Rui, Juiming Lin, Fei Yuan, Lianjun Du, Ji Zhang, Xiaoyi Ding
No abstract text is available yet for this article.
March 2018: Journal of Bone Oncology
https://www.readbyqxmd.com/read/29204337/effects-on-bone-resorption-markers-of-continuing-pamidronate-or-switching-to-zoledronic-acid-in-patients-with-high-risk-bone-metastases-from-breast-cancer
#5
J F Hilton, M Clemons, G Pond, H Zhao, S Mazzarello, L Vandermeer, C L Addison
Background: Switching patients who remain at high risk of skeletal related events (SREs) despite pamidronate to the more potent bisphosphonate zoledronate, may be an effective treatment strategy. As part of a previously reported clinic study in this setting, we evaluated whether biomarkers for bone resorption, such as Bone-Specific Alkaline Phosphatase (BSAP), bone sialoprotein (BSP), and N-terminal telopeptide (NTX) correlated with subsequent SRE risk. Methods: Breast cancer patients who remained at high risk of SREs despite at least 3 months of q...
March 2018: Journal of Bone Oncology
https://www.readbyqxmd.com/read/29234592/experience-of-total-scapular-excision-for-musculoskeletal-tumor-and-reconstruction-in-eastern-asian-countries
#6
Katsuhiro Hayashi, Xiaohui Niu, Xiaodong Tang, Vivek Ajit Singh, Apichat Asavamongkolkul, Akira Kawai, Norio Yamamoto, Toshiharu Shirai, Akihiko Takeuchi, Hiroaki Kimura, Shinji Miwa, Hiroyuki Tsuchiya
Total scapulectomy and reconstruction has been performed for scapular tumor, however, most of the reconstruction methods have resulted in poor functional outcomes and there is still room for improvement. Most of the reports of reconstruction after scapulectomy are from a single institution. In the present study, we investigated functional outcomes after total scapulectomy in a multicenter study in The Eastern Asian Musculoskeletal Oncology Group (EAMOG). Thirty-three patients who underwent total scapulectomy were registered at EAMOG affiliated hospitals...
November 2017: Journal of Bone Oncology
https://www.readbyqxmd.com/read/29234591/reproductive-hormone-analyses-and-effects-of-adjuvant-zoledronic-acid-in-early-breast-cancer-an-azure-big-01-04-sub-study
#7
Caroline Wilson, Samantha Hinsley, Helen Marshall, David Cameron, Richard Bell, David Dodwell, Robert E Coleman
Purpose: Adjuvant bisphosphonates have been shown to improve disease outcomes in early breast cancer in women who are postmenopausal at the start of treatment. We explored the influence of pretreatment serum levels of reproductive hormones in the hypothalamic-pituitary-gonadal (HPG) axis from a subset of patients included in the AZURE trial to investigate their impact on disease recurrence and whether reproductive hormone measurements are of value in selecting patients for treatment with adjuvant zoledronic acid...
November 2017: Journal of Bone Oncology
https://www.readbyqxmd.com/read/29234590/an-integrative-analysis-of-dna-methylation-in-osteosarcoma
#8
Jie Xu, Deng Li, Zhiqing Cai, Yingbin Zhang, Yulin Huang, Baohua Su, Ruofan Ma
Background: The study aimed to analyze aberrantly methylated genes, relevant pathways and transcription factors (TFs) in osteosarcoma (OS) development. Methods: Based on the DNA methylation microarray data GSE36002 that were downloaded from GEO database, the differentially methylated genes in promoter regions were identified between OS and normal samples. Pathway and function enrichment analyses of differentially methylated genes was performed. Subsequently, protein-protein interaction (PPI) network was constructed, followed by identification of cancer-associated differentially methylated genes and significant differentially methylated TFs...
November 2017: Journal of Bone Oncology
https://www.readbyqxmd.com/read/29234589/retrospective-study-of-predictors-of-bone-metastasis-in-colorectal-cancer-patients
#9
Zhenghong, Zihua Zhu, Guoweijian, Zhangning, Caiyunyun, Yingjiangshan, Xiaomi
Background: We explored risk factors for bone metastasis (BMs) in colorectal cancer (CRC) to improve in early diagnosis and follow-up and to reduce bone metastasis. Methods: With a retrospective analysis of 2066 patients with CRC treated in our institution from January 2006 to January 2015, we assessed high-risk variables associated with bone metastasis using univariate and multivariate analyses. Results: Of those subjects studied, 102 patients developed BMs, including 62 of 1014 the rectal cancer patients and 40 of the 1052 colon cancer patients...
November 2017: Journal of Bone Oncology
https://www.readbyqxmd.com/read/29226090/inhibition-of-il-18-mediated-myeloid-derived-suppressor-cell-accumulation-enhances-anti-pd1-efficacy-against-osteosarcoma-cancer
#10
Ying Guan, Rui Zhang, Zhibin Peng, Daming Dong, Guojun Wei, Yansong Wang
Myeloid derived suppressor cells (MDSC) are very important in tumor immune evasion and they dramatically increased in peripheral blood of patients with osteosarcoma cancer. The association between MDSC and various cytokines has been studied in the peripheral blood. However, little is known about the mechanism drawing MDSC into tumor parenchyma. This study was to analyze the correlation between MDSC subsets and interleukin 18 (IL-18) level in osteosarcoma tumor model and its effect on the immunotherapy. MDSC were isolated from the blood and parenchyma and analyzed in the osteosarcoma tumor model...
November 2017: Journal of Bone Oncology
https://www.readbyqxmd.com/read/29226089/oncolytic-adenoviruses-as-a-therapeutic-approach-for-osteosarcoma-a-new-hope
#11
REVIEW
Marc Garcia-Moure, Naiara Martinez-Vélez, Ana Patiño-García, Marta M Alonso
Osteosarcoma is the most common bone cancer among those with non-hematological origin and affects mainly pediatric patients. In the last 50 years, refinements in surgical procedures, as well as the introduction of aggressive neoadjuvant and adjuvant chemotherapeutic cocktails, have increased to nearly 70% the survival rate of these patients. Despite the initial therapeutic progress the fight against osteosarcoma has not substantially improved during the last three decades, and almost 30% of the patients do not respond or recur after the standard treatment...
November 2017: Journal of Bone Oncology
https://www.readbyqxmd.com/read/29159028/risk-factors-for-bone-metastasis-from-renal-cell-cancer
#12
Xuan-Yin Chen, Min Lan, Yang Zhou, Wen-Zhao Chen, Dong Hu, Jia-Ming Liu, Shan-Hu Huang, Zhi-Li Liu, Zhi-Hong Zhang
Objective: The prognosis for renal cell carcinoma (RCC) is related to a high rate of metastasis, including 30% of bone metastasis. In this study, we investigate the correlation between diverse clinical factors and bone metastases secondary from renal cell cancer (RCC), and to identify potential risk factors for bone metastasis in newly diagnosed patients and those who have already received treatment. Methods: The clinical data of 372 patients with RCC were reviewed from January 2000 to August 2016...
November 2017: Journal of Bone Oncology
https://www.readbyqxmd.com/read/29123990/the-skeletal-related-events-of-denosumab-versus-zoledronic-acid-in-patients-with-bone-metastases-a-meta-analysis-of-randomized-controlled-trials
#13
Zhicai Zhang, Feifei Pu, Zengwu Shao
Objective: The meta-analysis was used to evaluate the skeletal-related events (SREs) and efficacy of denosumab versus zoledronic acid (ZA) in patients with bone metastases. Methods: The data of this meta-analysis study were searched from PUBMED, EMBASE, Cochrane Library, Web of Science with Conference Proceedings, Elsevier and China National Knowledge Infrastructure (CNKI) databases till August 2017. Two independent reviewers reviewed the reference lists of relevant articles...
November 2017: Journal of Bone Oncology
https://www.readbyqxmd.com/read/29071206/estrogen-receptor-%C3%AE-exhibited-anti-tumor-effects-on-osteosarcoma-cells-by-regulating-integrin-iap-nf-kb-bcl-2-and-pi3k-akt-signal-pathway
#14
Minfei Yang, Bing Liu, Libin Jin, Huimin Tao, Zhengming Yang
This study aimed to investigate the effects of Estrogen receptor β (ERβ) on osteosarcoma cells, and explore the regulatory mechanisms involved in this process. Osteosarcoma U2-OS cells consisted four groups, and treated by E2, E2 + LY294002 (ERβ agonists), E2 + ERβ siRNA, E2 + ERβ siRNA + LY294002, respectively. Cell counting kit 8 (CCK-8) assay was performed to detect the cell viability of U2-OS cells in each group. The effects of ERβ on the migration and invasion ability of U2-OS cells were examined by wound healing assay and transwell cell culture chamber, respectively...
November 2017: Journal of Bone Oncology
https://www.readbyqxmd.com/read/29018768/soft-tissue-recurrence-of-giant-cell-tumor-of-the-bone-prevalence-and-radiographic-features
#15
Leilei Xu, Jing Jin, Annan Hu, Jin Xiong, Dongmei Wang, Qi Sun, Shoufeng Wang
AIM: Recurrence of giant cell tumor of bone (GCTB) in the soft tissue is rarely seen in the clinical practice. This study aims to determine the prevalence of soft tissue recurrence of GCTB, and to characterize its radiographic features. METHODS: A total of 291 patients treated by intralesional curettage for histologically diagnosed GCTB were reviewed. 6 patients were identified to have the recurrence of GCTB in the soft tissue, all of whom had undergone marginal resection of the lesion...
November 2017: Journal of Bone Oncology
https://www.readbyqxmd.com/read/28948139/the-role-of-biomarkers-in-the-management-of-bone-homing-malignancies
#16
REVIEW
Stella D'Oronzo, Janet Brown, Robert Coleman
Bone represents a common site of metastasis from several solid tumours, including breast, prostate and lung malignancies. The onset of bone metastases (BM) is associated not only with serious skeletal complications, but also shortened overall survival, owing to the lack of curative treatment options for late-stage cancer. Despite the diagnostic advances, BM detection often occurs in the symptomatic stage, underlining the need for novel strategies aimed at the early identification of high-risk patients. To this purpose, both bone turnover and tumour-derived markers are being investigated for their potential diagnostic, prognostic and predictive roles...
November 2017: Journal of Bone Oncology
https://www.readbyqxmd.com/read/28932679/osteochondroma-review-of-431-patients-from-one-medical-institution-in-south-china
#17
Kai Tong, Hongzhe Liu, Xiang Wang, Ziyi Zhong, Shenglu Cao, Chengjie Zhong, YunPing Yang, Gang Wang
BACKGROUND: The geographic distribution of osteochondroma (OC) varies greatly around the world. There has been no recent report on OC in a large Chinese population. The aim of this study was to characterize OC by an epidemiological analysis of the clinical data from one medical institution in South China. METHODS: We searched medical electronic records from January 2001 to January 2016 in one large hospital in South China to identify patients with a definite diagnosis of OC...
September 2017: Journal of Bone Oncology
https://www.readbyqxmd.com/read/28884071/increased-risk-of-sses-in-bone-only-metastatic-breast-cancer-patients-treated-with-zoledronic-acid
#18
Masashi Yanae, Shinichiro Fujimoto, Kaori Tane, Maki Tanioka, Kimiko Fujiwara, Masanobu Tsubaki, Yuzuru Yamazoe, Yoshiyuki Morishima, Yasutaka Chiba, Shintaro Takao, Yoshifumi Komoike, Junji Tsurutani, Kazuhiko Nakagawa, Shozo Nishida
BACKGROUND: Bone represents one of the most common sites to which breast cancer cells metastasize. Patients experience skeletal related adverse events (pathological fractures, spinal cord compressions, and irradiation for deteriorated pain on bone) even during treatment with zoledronic acid (ZA). Therefore, we conducted a retrospective cohort study to investigate the predictive factors for symptomatic skeletal events (SSEs) in bone-metastasized breast cancer (b-MBC) patients. METHODS: We retrospectively collected data on b-MBC patients treated with ZA...
September 2017: Journal of Bone Oncology
https://www.readbyqxmd.com/read/28856087/complications-of-bone-metastases-from-malignant-melanoma
#19
Jamal Zekri, Maria Marples, Dominic Taylor, Kiran Kandukurti, Lucy McParland, Janet E Brown
INTRODUCTION: Metastatic bone disease (MBD) carries significant morbidity for patients with cancer. MBD from malignant melanoma (MM) is understudied. We examined the characteristics, morbidity, management and outcome of MBD in patients with MM. METHODS: Patients with metastatic MM managed at two referral cancer centres in England were identified. Those with bone metastases (BMs) were selected. Patient and disease characteristics including skeletal related events (SREs) were extracted from medical records...
September 2017: Journal of Bone Oncology
https://www.readbyqxmd.com/read/28856086/identification-of-novel-targets-for-multiple-myeloma-through-integrative-approach-with-monte-carlo-cross-validation-analysis
#20
Congjian Liu, Xiang Gu, Zhenxian Jiang
More than one pathway is involved in disease development and progression, and two or more pathways may be interconnected to further affect the disease onset, as functional proteins participate in multiple pathways. Thus, identifying cross-talk among pathways is necessary to understand the molecular mechanisms of multiple myeloma (MM). Based on this, this paper looked at extracting potential pathway cross-talk in MM through an integrative approach using Monte Carlo cross-validation analysis. The gene expression library of MM (accession number: GSE6477) was downloaded from the Gene Expression Omnibus (GEO) database...
September 2017: Journal of Bone Oncology
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