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Journal of Bone Oncology

Peyman Hadji, Oliver Stoetzer, Thomas Decker, Christian M Kurbacher, Frederik Marmé, Andreas Schneeweiss, Christoph Mundhenke, Andrea Distelrath, Peter A Fasching, Michael P Lux, Diana Lüftner, Wolfgang Janni, Mathias Muth, Julia Kreuzeder, Claudia Quiering, Eva-Marie Grischke, Hans Tesch
Background: Breast cancer and its treatments are associated with a detrimental effect on bone health. Here we report the results of an exploratory analysis assessing changes in levels of biomarkers of bone metabolism in patients enrolled in the phase IIIb 4EVER study. Methods: The 4EVER trial investigated everolimus in combination with exemestane in postmenopausal women with hormone receptor-positive, human epidermal growth factor receptor 2-negative locally advanced or metastatic breast cancer...
February 2019: Journal of Bone Oncology
Lise Clément-Demange, Patrick L Mulcrone, Troy Q Tabarestani, Julie A Sterling, Florent Elefteriou
Progression and recurrence of breast cancer, as well as reduced survival of patients with breast cancer, are associated with chronic stress, a condition known to impact the hypothalamic-pituitary axis and the autonomic nervous system. Preclinical and clinical evidence support the involvement of the sympathetic nervous system in the control of bone remodeling and in pathologies of the skeleton, including bone metastasis. In experimental mouse models of skeletal metastasis, administration of the βAR agonist isoproterenol (ISO), used as a surrogate of norepinephrine, the main neurotransmitter of sympathetic neurons, was shown to favor bone colonization of metastatic breast cancer cells via an increase bone marrow vascularity...
November 2018: Journal of Bone Oncology
Debjit Chakraborty, Sukanya Rangamani, Vaitheeswaran Kulothungan, Meesha Chaturvedi, S Stephen, Priyanka Das, Kondalli Lakshminarayana Sudarshan, R Janani Surya, K Sathish Kumar, Anish John, N Manoharan, S S Koyande, Rajaraman Swaminathan, C Ramesh, Atul Shrivastava, B Ganesh, Prashant Mathur, Ambakumar Nandakumar
Background: Ewing sarcoma is a malignant tumour found mainly in childhood and adolescence. The present study aims at analyzing the data on Ewing sarcoma cases of bone from the National Cancer Registry Programme, India to provide incidence, patterns, and trends in the Indian population. Materials and Methods: The data of five Population Based Cancer Registries (PBCR) of Bangalore, Mumbai, Chennai, Bhopal and Delhi over 30 years period (1982- 2011) were used to calculate the Age Specific and Age Standardized Incidence Rates (ASpR and ASIR), and trends in incidence was analyzed by linear and Joinpoint Regression...
September 2018: Journal of Bone Oncology
Hongyi Li, Xianbiao Xie, Junqiang Yin, Jian Tu, Xiaoshuai Wang, Weihai Liu, Jiajun Zhang, Hongbo Li, Changye Zou, Yongqian Wang, Jingnan Shen, Gang Huang
Background: The treatment algorithm for solitary bone lesions of Langerhans cell histiocytosis (SBL-LCH) in children extremities still remains controversial. We conducted a retrospective case-control study to compare the feasibility of low-dose chemotherapy (LDC) and surgery for SBL-LCH in children extremities. Patients and methods: This study compares 43 pediatric patients starting LDC with a surgery control group (n = 44), matched for gender, age, follow-up time, and lesion sites and sizes, treated between 2001 and 2015 at our institution...
September 2018: Journal of Bone Oncology
Min Lan, Xiao-Ping Zhu, Zhi-Yuan Cao, Jia-Ming Liu, Qing Lin, Zhi-Li Liu
Osteosarcoma (OS) is the most common non-hematologic malignant tumor of bone in children. It is usually characterized by a high risk of developing lung metastasis and poor prognosis. Extracellular vesicles (EVs) are cell-derived nanoparticles with a small size of 50-200 nm in diameter. As a communicator, the contents of the EVs secreted via either fusing with lysosomes for degradation and recycling or fusing with the cell plasma membrane into the extracellular environment, which play an important role in regulating the tumor microenvironment of OS and mediating the Wnt/β-catenin and TGF-β signalings...
September 2018: Journal of Bone Oncology
Alexander Liede, Rohini K Hernandez, En-Tzu Tang, Chuang Li, Brian Bennett, Steven S Wong, Danielle Jandial
Background: Quantifying the incidence of giant cell tumor (GCT) of bone is challenging because it is a rare, histologically benign bone tumor for which population-level statistics are unavailable in most countries. We estimated the 2017 incidence of GCT in China using a direct (registry-based) approach with available population-based data. Materials and Methods: The most recent age- and sex-specific incidence rates of GCT recorded in the Bone Tumor Registry in Japan (2015) were applied to 2017 age- and sex-matched populations projected by the United Nations for China in order to estimate 2017 incidence...
September 2018: Journal of Bone Oncology
Vanessa Rouach, Inbal Goldshtein, Ido Wolf, Raphael Catane, Gabriel Chodick, Amit Iton, Naftali Stern, Daniel Cohen
Background: Bisphosphonate (BP) treatment to prevent bone loss in breast cancer patients is already well established. However, data on the association between oral BP exposure before cancer diagnosis and disease outcomes in patients with early breast cancer are still scarce. Limited information is available on alendronate, the most common oral agent for the treatment of post-menopausal osteoporosis, regarding the association with bone metastases. Aim: To examine the association between oral bisphosphonate exposure before cancer diagnosis and the risk of bone metastases in osteoporotic women diagnosed with early breast cancer...
September 2018: Journal of Bone Oncology
Antoine Chalopin, Marta Tellez-Gabriel, Hannah K Brown, François Vallette, Marie-Françoise Heymann, Francois Gouin, Dominique Heymann
Osteosarcoma is a rare primary bone tumor, which mainly affects children and adolescents and has a poor prognosis, especially for patients with metastatic disease. A poor therapeutic response to the conventional chemotherapy is observed with the development of lung metastases, highlighting the need for improving the current regimens and the identification of early markers of the recurrent and metastatic disease. Circulating Tumour Cells (CTCs) play a key role in the metastatic process and could be powerful biomarkers of the progressive disease...
September 2018: Journal of Bone Oncology
Dong Liu, Jun Fu, Hongbin Fan, Dichen Li, Enchun Dong, Xin Xiao, Ling Wang, Zheng Guo
Background: Bone benign fibrous histiocytoma (BFH) is an invasive primary bone tumor. When the local excision is not complete, the risk of recurrence is high, and hence, one-piece resection is necessary. The major challenge for clinicians is to reconstruct the bone after resection of the tumor. The present study investigated the efficacy of 3-dimensional (3D) printing technique in the treatment of benign fibrous histiocytoma of the scapula. Methods: The patient with benign fibrous histiocytoma of scapular bone was treated with PEEK (polyetheretherketone) prosthesis replacement using the 3D printing technique...
September 2018: Journal of Bone Oncology
Wei Zhao, Zhao-Hong Peng, Jin-Zhou Chen, Ji-Hong Hu, Jian-Qiang Huang, Yong-Neng Jiang, Gang Luo, Gen-Fa Yi, Hui Wang, Shen Jin, Bu-Lang Gao
Purpose: To investigate effects and heat distribution of radiofrequency ablation (RFA) on vertebral tumors in vitro and in vivo swine experiments and its clinical application. Materials and methods: RFA was performed on the swine spine in vitro and in vivo for 20 min at 90 °C at the electrode tip, and the temperature at the electrode tip and surrounding tissues were recorded. Clinical application of ablation combined with vertebroplasty was subsequently performed in 4 patients with spinal tumors...
September 2018: Journal of Bone Oncology
Meng Du, Yongfeng Wang, Wei Zhao, Zhiquan Wang, Jie Yuan, Hongying Bai
Objective: The aim of this meta-analysis was to analysis the expression of livin in human osteosarcoma. Methods: We searched the Pubmed, Science Direct, Embase and Web of Science, CNKI, Wanfang and VIP for relevant original studies. Statistical analysis was performed by Stata 11.0 software. Results: Our study indicated that livin expressed in the osteosarcoma tissue was significantly higher than the control group (OR = 18.814, P c = 0...
September 2018: Journal of Bone Oncology
Leilei Xu, Chao Xia, Qi Sun, Fei Sheng, Jin Xiong, Shoufeng Wang
Objectives: Previous pharmacogenetics studies showed that genetic variants could be indicative of the response to chemotherapy. We aimed to investigate whether variants of FasL, MSH2, ABCC5, CASP3 and CYP3A4 are associated with the outcome after chemotherapy-based treatment in osteosarcoma. Methods: 132 osteosarcoma patients who had completed the neoadjuvant chemotherapy in our center were included. 5-year progression-free survival (PFS) was assessed from the initial treatment to the earliest sign of disease progression or death from any cause...
September 2018: Journal of Bone Oncology
Chenglong Zhao, Zhichao Zhang, Nanzhe Zhong, Tianqi Fan, Xin Gao, Zhipeng Wu, Zhenxi Li, Tielong Liu, Jianru Xiao
Purpose: The aim of this study is to provide some useful insights into the treatments, outcomes, and prognostic factors of patients with breast cancer spine metastases (BCSM). Methods: We report a retrospective case series analyzing 87 patients with BCSM who underwent surgical interventions. Independent prognostic factors for SMFS and OS were extracted using univariate and multivariate analyses, the Kaplan-Meier method and the Cox proportional hazards model. Results: The mean time between primary diagnoses and spinal metastases was 46...
September 2018: Journal of Bone Oncology
D Santini, G Brandi, G Aprile, M Russano, S Cereda, F Leone, S Lonardi, L Fornaro, M Scartozzi, N Silvestris, S Barni, F Pantano, B Vincenzi, A Palloni, G Frega, M Casagrande, L Ferrari, V Dadduzio, R Intini, R Filippi, E Vasile, C Vivaldi, L Faloppi, O Brunetti, M Reni, M Aglietta, G Tonini
•Natural history of biliary cancers metastatic to bone•The role of skeletal events in patients with biliary cancer•Biliary cancer and bone metastases: role of bisphosphonates.
September 2018: Journal of Bone Oncology
Leilei Xu, Chao Xia, Bingchuan Xue, Fei Sheng, Jin Xiong, Shoufeng Wang
Background: Previous studies showed that genetic variant rs145204276 in the promoter region of GAS5 was associated with the development of human cancer including colorectal cancer and hepatocellular cancer. This study aimed to investigate the role of rs145204276 in the development of osteosarcoma (OS). Methods: 132 OS patients and 1270 healthy controls were recruited for the genotyping analysis of rs145204276. Promoter methylation level of GAS5 was determined for all patients...
September 2018: Journal of Bone Oncology
Jun Hua, Dong Liu, Lumin Cao, Dengfeng Wang, Tao Wu, Fanguo Lin, Peng Su, Yanping Niu, Yongming Sun
Objective: In view of the poor prognosis and difficulties in the diagnosis of osteosarcoma, and the functionality of microRNA-Let7A in different types of human cancers, our study aimed to explore the diagnostic and prognostic values of microRNA-Let7A for osteosarcoma. Methods: A total of 39 patients with osteosarcoma and 19 normal healthy people were included in this study. All patients received surgical resection, and tumor tissues as well as pericarcinomatous tissues were collected during surgical operation...
September 2018: Journal of Bone Oncology
Liming Xia, Hao Wu, Wenkang Qian
Brain metastasis of osteosarcoma are rare but carry a dismal prognosis. Despite the advances in both systemic immunotherapy and localized radiation, it is still difficult to treat brain metastasis, with less than 12 months of survival from the time of diagnosis for most patients. Currently, there is interest in combining strategies to take advantage of the potential synergy. In this study, the mouse model of metastatic osteosarcoma to brain was used to explore the ability of local radiation and anti-PD-1 blockade to induce beneficial anti-tumor immune responses against distant, unirradiated brain metastatic tumors...
September 2018: Journal of Bone Oncology
Ya Zhang, Zewei He, Yanping Duan, Cao Wang, Santoshi Kamar, Xiaoqian Shi, Jifei Yang, Jingqing Yang, Na Zhao, Lei Han, Yihao Yang, Zuozhang Yang
Study Design: Meta-analysis. Background: Although some new insights have been offered for clinical and scientific relevance, minor progress has been made in osteosarcoma treatment after a dramatic survival improvement in the late 1980s with the addition of chemotherapy to surgery. Intensified chemotherapy strategies have been suggested to increase the survival rate of patients with osteosarcoma. We performed this study to access whether intensified chemotherapy strategiesincreased survival outcomes of osteosarcoma patients compared with conventional chemotherapy strategies...
September 2018: Journal of Bone Oncology
Taylor J Reif, Patrick K Strotman, Stephanie A Kliethermes, Benjamin J Miller, Lukas M Nystrom
Objectives: Metastatic disease involving the femoral head and neck is often treated with a hemiarthroplasty or total hip arthroplasty (THA) to prevent pathologic fracture but there are no outcome studies demonstrating superiority of one option over the other. Methods: This investigation was designed as a survey of the current members of the Musculoskeletal Tumor Society (MSTS). The survey contained seven clinical vignettes with identical imaging of a pathologic lesion of the femoral head and neck...
September 2018: Journal of Bone Oncology
Camille Jacques, Nathalie Renema, Frederic Lezot, Benjamin Ory, Carl R Walkley, Agi E Grigoriadis, Dominique Heymann
Osteosarcoma, Ewing sarcoma and chondrosarcoma are the three main entities of bone sarcoma which collectively encompass more than 50 heterogeneous entities of rare malignancies. In contrast to osteosarcoma and Ewing sarcoma which mainly affect adolescents and young adults and exhibit a high propensity to metastasise to the lungs, chondrosarcoma is more frequently observed after 40 years of age and is characterised by a high frequency of local recurrence. The combination of chemotherapy, surgical resection and radiotherapy has contributed to an improved outcome for these patients...
September 2018: Journal of Bone Oncology
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