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Journal of Bone Oncology

Wei Zhao, Zhao-Hong Peng, Jin-Zhou Chen, Ji-Hong Hu, Jian-Qiang Huang, Yong-Neng Jiang, Gang Luo, Gen-Fa Yi, Hui Wang, Shen Jin, Bu-Lang Gao
Purpose: To investigate effects and heat distribution of radiofrequency ablation (RFA) on vertebral tumors in vitro and in vivo swine experiments and its clinical application. Materials and methods: RFA was performed on the swine spine in vitro and in vivo for 20 min at 90 °C at the electrode tip, and the temperature at the electrode tip and surrounding tissues were recorded. Clinical application of ablation combined with vertebroplasty was subsequently performed in 4 patients with spinal tumors...
September 2018: Journal of Bone Oncology
Meng Du, Yongfeng Wang, Wei Zhao, Zhiquan Wang, Jie Yuan, Hongying Bai
Objective: The aim of this meta-analysis was to analysis the expression of livin in human osteosarcoma. Methods: We searched the Pubmed, Science Direct, Embase and Web of Science, CNKI, Wanfang and VIP for relevant original studies. Statistical analysis was performed by Stata 11.0 software. Results: Our study indicated that livin expressed in the osteosarcoma tissue was significantly higher than the control group (OR = 18.814, P c = 0...
September 2018: Journal of Bone Oncology
Leilei Xu, Chao Xia, Qi Sun, Fei Sheng, Jin Xiong, Shoufeng Wang
Objectives: Previous pharmacogenetics studies showed that genetic variants could be indicative of the response to chemotherapy. We aimed to investigate whether variants of FasL, MSH2, ABCC5, CASP3 and CYP3A4 are associated with the outcome after chemotherapy-based treatment in osteosarcoma. Methods: 132 osteosarcoma patients who had completed the neoadjuvant chemotherapy in our center were included. 5-year progression-free survival (PFS) was assessed from the initial treatment to the earliest sign of disease progression or death from any cause...
September 2018: Journal of Bone Oncology
Chenglong Zhao, Zhichao Zhang, Nanzhe Zhong, Tianqi Fan, Xin Gao, Zhipeng Wu, Zhenxi Li, Tielong Liu, Jianru Xiao
Purpose: The aim of this study is to provide some useful insights into the treatments, outcomes, and prognostic factors of patients with breast cancer spine metastases (BCSM). Methods: We report a retrospective case series analyzing 87 patients with BCSM who underwent surgical interventions. Independent prognostic factors for SMFS and OS were extracted using univariate and multivariate analyses, the Kaplan-Meier method and the Cox proportional hazards model. Results: The mean time between primary diagnoses and spinal metastases was 46...
September 2018: Journal of Bone Oncology
D Santini, G Brandi, G Aprile, M Russano, S Cereda, F Leone, S Lonardi, L Fornaro, M Scartozzi, N Silvestris, S Barni, F Pantano, B Vincenzi, A Palloni, G Frega, M Casagrande, L Ferrari, V Dadduzio, R Intini, R Filippi, E Vasile, C Vivaldi, L Faloppi, O Brunetti, M Reni, M Aglietta, G Tonini
•Natural history of biliary cancers metastatic to bone•The role of skeletal events in patients with biliary cancer•Biliary cancer and bone metastases: role of bisphosphonates.
September 2018: Journal of Bone Oncology
Leilei Xu, Chao Xia, Bingchuan Xue, Fei Sheng, Jin Xiong, Shoufeng Wang
Background: Previous studies showed that genetic variant rs145204276 in the promoter region of GAS5 was associated with the development of human cancer including colorectal cancer and hepatocellular cancer. This study aimed to investigate the role of rs145204276 in the development of osteosarcoma (OS). Methods: 132 OS patients and 1270 healthy controls were recruited for the genotyping analysis of rs145204276. Promoter methylation level of GAS5 was determined for all patients...
September 2018: Journal of Bone Oncology
Jun Hua, Dong Liu, Lumin Cao, Dengfeng Wang, Tao Wu, Fanguo Lin, Peng Su, Yanping Niu, Yongming Sun
Objective: In view of the poor prognosis and difficulties in the diagnosis of osteosarcoma, and the functionality of microRNA-Let7A in different types of human cancers, our study aimed to explore the diagnostic and prognostic values of microRNA-Let7A for osteosarcoma. Methods: A total of 39 patients with osteosarcoma and 19 normal healthy people were included in this study. All patients received surgical resection, and tumor tissues as well as pericarcinomatous tissues were collected during surgical operation...
September 2018: Journal of Bone Oncology
Liming Xia, Hao Wu, Wenkang Qian
Brain metastasis of osteosarcoma are rare but carry a dismal prognosis. Despite the advances in both systemic immunotherapy and localized radiation, it is still difficult to treat brain metastasis, with less than 12 months of survival from the time of diagnosis for most patients. Currently, there is interest in combining strategies to take advantage of the potential synergy. In this study, the mouse model of metastatic osteosarcoma to brain was used to explore the ability of local radiation and anti-PD-1 blockade to induce beneficial anti-tumor immune responses against distant, unirradiated brain metastatic tumors...
September 2018: Journal of Bone Oncology
Ya Zhang, Zewei He, Yanping Duan, Cao Wang, Santoshi Kamar, Xiaoqian Shi, Jifei Yang, Jingqing Yang, Na Zhao, Lei Han, Yihao Yang, Zuozhang Yang
Study Design: Meta-analysis. Background: Although some new insights have been offered for clinical and scientific relevance, minor progress has been made in osteosarcoma treatment after a dramatic survival improvement in the late 1980s with the addition of chemotherapy to surgery. Intensified chemotherapy strategies have been suggested to increase the survival rate of patients with osteosarcoma. We performed this study to access whether intensified chemotherapy strategiesincreased survival outcomes of osteosarcoma patients compared with conventional chemotherapy strategies...
September 2018: Journal of Bone Oncology
Taylor J Reif, Patrick K Strotman, Stephanie A Kliethermes, Benjamin J Miller, Lukas M Nystrom
Objectives: Metastatic disease involving the femoral head and neck is often treated with a hemiarthroplasty or total hip arthroplasty (THA) to prevent pathologic fracture but there are no outcome studies demonstrating superiority of one option over the other. Methods: This investigation was designed as a survey of the current members of the Musculoskeletal Tumor Society (MSTS). The survey contained seven clinical vignettes with identical imaging of a pathologic lesion of the femoral head and neck...
September 2018: Journal of Bone Oncology
Camille Jacques, Nathalie Renema, Frederic Lezot, Benjamin Ory, Carl R Walkley, Agi E Grigoriadis, Dominique Heymann
Osteosarcoma, Ewing sarcoma and chondrosarcoma are the three main entities of bone sarcoma which collectively encompass more than 50 heterogeneous entities of rare malignancies. In contrast to osteosarcoma and Ewing sarcoma which mainly affect adolescents and young adults and exhibit a high propensity to metastasise to the lungs, chondrosarcoma is more frequently observed after 40 years of age and is characterised by a high frequency of local recurrence. The combination of chemotherapy, surgical resection and radiotherapy has contributed to an improved outcome for these patients...
September 2018: Journal of Bone Oncology
Maurizio Zangari, Hanna Yoo, Ik Jae Shin, Donghoon Yoon, Larry J Suva
The 5TGM1 multiple myeloma transplanted C57BL6/KaLwRij model recapitulates many disease features including monoclonal paraprotein production as well as the development of osteolytic bone lesions. Since a significant association between serum parathyroid hormone PTH variations, bone anabolism and myeloma progression in patients receiving proteasome inhibitors exists, this study investigated the effect of the PTH axis on murine myeloma development in vivo . C57BL6/KaLwRij myeloma-bearing mice underwent thyroparathyroidectomy (TPTX) before and after 5TGM1 cell transplantation...
September 2018: Journal of Bone Oncology
Yue Wang, Xiaokai Zhang, Liangliang Yang, Jinru Xue, Guangrui Hu
Myeloid derived suppressor cells (MDSC) play a pivotal role in tumor immune evasion and MDSC levels increased in patients with cancer. Studies confirmed the associations between MDSC and various cytokines in the peripheral blood. However, little is known about the association between parenchymal MDSC subsets and cytokines, or the mechanism drawing MDSC into tumor parenchyma. This study was to analyze the correlation between MDSC subsets and CCL2 level in lung cancer model. G-MDSC and M-MDSC from the blood and parenchyma were analyzed by flow cytometry and western blot in the lung tumor model...
June 2018: Journal of Bone Oncology
Qizhou Zhang, Kunyao Zhang, Bing Xie, Yimin Ren, Guoliang Li, Liping Zhang, Aijing Wang, Yang Li
The aims of this study were to investigate the clinical effects of I125 implantation combined with radiofrequency ablation in treating bone metastases (BM) and analyze its clinical application so as to provide better treatment protocols for the treatment of BM. A total of 63 BM patients were randomly divided into the I125 implantation group (CON, treated with I125 seeds alone, 33 patients) and the combination group (I125 -MA, 30 patients) to compare the clinical efficacy and adverse effects. After treatment, the clinical efficacy of Group I125 -MA was significantly better than Group CON, and the quality of life was improved significantly (P< 0...
June 2018: Journal of Bone Oncology
Jun-Qiang Yin, Yi-Wei Fu, Xian-Biao Xie, Xiao-Yu Cheng, Xiao-Yu Yang, Wei-Hai Liu, Jian Tu, Zhen-Hua Gao, Jing-Nan Shen
Background and purpose: Telangiectatic osteosarcoma (TOS), a rare variant of osteosarcoma, may be easily misdiagnosed as aneurysmal bone cyst (ABC). The aims of this study were to investigate the diagnostic and prognostic factors of TOS by reviewing our experience with TOS and to develop a diagnostic model that may distinguish TOS from ABC. Materials and methods: We identified 51 cases of TOS treated at the First Affiliated Hospital of Sun Yat-Sen University from March 2001 to January 2016 and reviewed their records, imaging information and pathological studies...
June 2018: Journal of Bone Oncology
Roger von Moos, Jean-Jacques Body, Alex Rider, Jonathan de Courcy, Debajyoti Bhowmik, Francesca Gatta, Guy Hechmati, Yi Qian
Background: Bone metastases (BMs) are common in patients with breast cancer and can lead to skeletal-related events (SREs), which are associated with increased pain and reduced quality of life (QoL). Bone-targeted agents (BTAs), like zoledronic acid and denosumab, reduce the incidence of SREs and delay progression of bone pain. Materials and methods: We evaluated the management of BMs and pain in six European countries (Belgium, France, Germany, Italy, Spain, and UK) using the Adelphi Breast Cancer Disease Specific Programme, which included a physician survey and patient-reported outcomes (PROs) to assess the impact of BMs on pain and QoL...
June 2018: Journal of Bone Oncology
Maiko Shibasaki, Toshinori Iwai, Senri Oguri, Toshiyuki Koizumi, Makoto Hirota, Kenji Mitsudo, Yukihiko Ozawa, Iwai Tohnai
Introduction: Although chemoradiotherapy (CRT) for oral squamous cell carcinoma (SCC) has been shown to preserve organ function and improve cosmetic results, site-specific data, especially mandible, are limited. The aim of this study was to evaluate the predictability of 18F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) on response to super-selective intra-arterial CRT for advanced SCC of the mandible. Methods: Fifteen patients with advanced SCC of the mandible underwent super-selective intra-arterial CRT followed by radical resection...
June 2018: Journal of Bone Oncology
Guangyang Yu, Gang Liu, Dongtang Yuan, Jian Dai, Yin Cui, Xiaoming Tang
Aim: Increasing evidence has shown that long noncoding RNAs (lncRNAs) ANRIL may function as oncogenes in various types of malignancies. However, there is still a lack of knowledge concerning its role in osteosarcoma (OS). In this study, we aimed to investigate the influence of ANRIL on cell proliferation and invasion of OS and to determine its association with clinicopathological features of the patients. Methods: The tumor specimens and the adjacent normal tissues were collected from 57 OS patients and the expression level of ANRIL was quantified by RT-qPCR...
June 2018: Journal of Bone Oncology
Hongwei Zhang, Wei Zhu, Ewelina Biskup, Weige Yang, Ziang Yang, Hong Wang, Xiaochun Qiu, Chengjiao Zhang, Guangxia Hu, Guangfu Hu
Purpose: The aim was to systematically extrapolate the occurrence, risk factors, prognostic characteristics, management and outcome of bone metastases (BM) and skeletal related events (SREs) of breast cancer survivors in the real world clinical setting. Methods: A systematic literature search of PubMed, Web of Science, EMBASE OvidSP and EBSCO Academic Search Complete was conducted. Published prospective and retrospective papers investigating BM and SREs in breast cancer patients in non-trial settings were identified and systematically reviewed...
June 2018: Journal of Bone Oncology
Hao Li, Xiaodong Fu, Yingjian Gao, Xiaomiao Li, Yi Shen, Weili Wang
Purpose: Osteosarcoma is the most widespread primary carcinoma in bones. Osteosarcoma cells are highly metastatic and frequently develop resistance to chemotherapy making this disease harder to treat. This identifies an urgent need of novel therapeutic strategies for osteosarcoma. G-Protein-coupled receptor 137 (GPR137) is involved in several human cancers and may be a novel therapeutic target. Methods: The expression of GPR137 was assessed in one osteoblast and three human osteosarcoma cell lines via the quantitative real-time polymerase chain reaction and western blot assays...
June 2018: Journal of Bone Oncology
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