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Respiratory Medicine Case Reports

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https://www.readbyqxmd.com/read/28913162/endobronchial-hamartoma-a-rare-structural-cause-of-chronic-cough
#1
Saman Ahmed, Ayesha Arshad, M Jeffery Mador
Pulmonary hamartomas are rare benign tumors consisting of multiple mesenchymal cell lines like cartilage, bone and fat. We discuss an interesting case of a 53-year-old male patient, who was referred to our clinic for persistent cough. Chest X-ray revealed a left suprahilar density associated with plate like atelectasis, which on chest CT was found to be a densely calcified nodule, causing narrowing of the left upper lobe (LUL) bronchus with calcified bilateral hilar lymph nodes. A bronchoscopy revealed a smooth endobronchial mass with calcification, which was removed...
2017: Respiratory Medicine Case Reports
https://www.readbyqxmd.com/read/28913161/a-young-immunocompetent-patient-with-spontaneous-aspergillus-empyema-who-developed-severe-eosinophilia
#2
Fumiaki Kudo, Hiromitsu Ohta, Yoshiaki Nagai, Kentaro Minegishi, Shinichiro Koyama
Aspergillus empyema is usually reported as a complication of surgical procedures, and spontaneous cases are quite rare. Here, we describe the case of a 16-year-old man who suddenly developed dyspnea despite previously being healthy. Chest computed tomography showed multiple mass-containing cavity lesions, pneumothorax, and pleural effusion in the left thorax. Within 2 weeks, Aspergillus fumigatus grew from his pleural effusion, thus he was diagnosed with Aspergillus empyema. He also developed severe eosinophilia after admission, and was treated with anti-fungal drugs...
2017: Respiratory Medicine Case Reports
https://www.readbyqxmd.com/read/28913160/pancoast-tumor-approach-through-oesophagus
#3
Eritjan Tashi, Perlat Kapisyzi, Daniela Xhemalaj, Alma Andoni, Ilir Peposhi
Patient with Pancoast Tumor usually present in advanced stage of the disease which requires chemotherapy and radiotherapy as options of treatment. Histologic confirmation is a key for further treatment of these patients. Normally in bronchoscopy the lesion can't be visualised and in result making biopsy difficult to perform. Transthoracic biopsy through computed tomography poses anatomic difficulties and not always the pulmonary lesion can be reached. We report a case of pancoast tumor in a 68 year old male who presented with left arm pain and upper lobe increased density mass in chest x ray...
2017: Respiratory Medicine Case Reports
https://www.readbyqxmd.com/read/28884072/ochroconis-gallopava-bronchitis-mimicking-haemoptysis-in-a-patient-with-bronchiectasis
#4
M Bernasconi, C Voinea, P M Hauser, L P Nicod, R Lazor
Ochroconis gallopava is an anamorphic mould characterized by slow growth rate and production of a maroon pigment, which has been isolated worldwide from soil, thermal springs, decaying vegetation, and chicken litter. It has been reported to cause localized, mostly pulmonary, and systemic infection in severely immunocompromised patients. We describe the case of a 76-year-old woman known for ulcerative colitis-related bronchiectasis treated with low dose oral steroids, who developed a fungal bronchitis with dark, bloody-like, sputum which was initially misinterpreted as haemoptysis...
2017: Respiratory Medicine Case Reports
https://www.readbyqxmd.com/read/28879080/diffuse-parenchymal-lung-disease-with-micro-aspirations-in-presence-of-hiatal-hernia
#5
Rishitha Yelisetti, Areig Awad, Anand Kaji
There has been controversy regarding the relationship between gastroesophageal reflux, microaspiration, and idiopathic pulmonary fibrosis (IPF). In the last decade, there is increasing evidence supporting a relationship between gastroesophageal reflux, microaspiration, and IPF. The presence of hiatal hernia further propagates microaspirations. Surgical management of hiatal hernia plays a vital role in the treatment.
2017: Respiratory Medicine Case Reports
https://www.readbyqxmd.com/read/28879079/intrathoracic-ganglioneuroma-presenting-as-an-endobronchial-mass
#6
Brandon T Nokes, Coralie P Baumann, Kristopher W Cummings, Brandon T Larsen, Rodrigo Cartin-Ceba, Karen L Swanson
Peripheral nerve sheath tumors (PNST) are exceedingly rare, especially outside of the posterior mediastinum. These tumors represent less than 1% of pulmonary tumors. Very few pulmonary PNSTs are ganglioneuromas. We present a case of a ganglioneuroma presenting as an endobronchial mass. CASE PRESENTATION: An 80 year old male was seen in pulmonary clinic for routine cancer screening. He had a 60-pack year smoking history. CT evaluation noted a 1cm right lower lobe endobronchial lesion. This lesion was present since 2012 and had slightly increased in size since that time from 8mm (Figure 1)...
2017: Respiratory Medicine Case Reports
https://www.readbyqxmd.com/read/28879078/left-ventricle-and-systemic-air-embolism-after-percutaneous-lung-biopsy
#7
Juan M Galvis, David R Nunley, Teoh Zheyi, Lu Anne V Dinglasan
BACKGROUND: Systemic arterial air embolism following a percutaneous transthoracic lung biopsy is a rare but known complication, with current literature reporting an incidence of 0.01-0.45%. A prompt diagnosis of arterial air embolism is important as complications resulting from migration of air to the systemic circulation with correspondent complications. CASE REPORT: A 60-year-old female who presented for an elective percutaneous lung biopsy of an incidentally found pulmonary nodule...
2017: Respiratory Medicine Case Reports
https://www.readbyqxmd.com/read/28879077/a-rare-case-of-actinomyces-meyeri-empyema-still-a-challenging-entity-to-manage
#8
Vera Clérigo, Lígia Fernandes, Amélia Feliciano, Lurdes Carvalho
Actinomyces meyeri is a rare pathogen and an infrequent cause of human actinomycosis. Less than ten cases were reported in the English-literature to date concerning A. meyeri empyema. We herein report a case to promote the awareness and adequate management of the disease. A 44-year-old immunocompetent male with known pulmonary disease was diagnosed with an A. meyeri empyema. He underwent chest tube drainage and a short-term treatment with clindamycin for 4 months. This is the first report of a patient with structural pulmonary disease with an A...
2017: Respiratory Medicine Case Reports
https://www.readbyqxmd.com/read/28879076/immunotherapy-shock-a-case-series-of-pd-l1-100-and-pembrolizumab-first-line-treatment
#9
Paul Zarogoulidis, Evaggelia Athanasiou, Theodora Tsiouda, Dimitrios Hatzibougias, Haidong Huang, Chong Bai, Georgia Trakada, Lemonia Veletza, Anastasios Kallianos, Christoforos Kosmidis, Nikolaos Barbetakis, Dimitrios Paliouras, Aggeliki Rapti, Dimitrios Drougas, Wolfgang Hohenforst-Schmidt
In this decade a "bloom" of novel therapies has been observed for non-small cell lung cancer. We have new tools for the diagnosis of lung cancer and also we can re-biospy easier than before in different lesions and obtain tissue samples in order to investigate whether a patient can receive new targeted therapies. Immunotherapy has been well established previously for other forms of cancer, and nowadays it is also available for lung cancer. There are two immunotherapies for now nivolumab and pembrolizumab which can be administered as second line treatment, the second can also be administered as first-line if there is a programmed death-ligand 1 ≥50% expression...
2017: Respiratory Medicine Case Reports
https://www.readbyqxmd.com/read/28879075/endobronchial-ultrasound-convex-probe-for-lymphoma-sarcoidosis-lung-cancer-and-other-thoracic-entities-a-case-series
#10
Paul Zarogoulidis, Haidong Huang, Chong Bai, Christoforos Kosmidis, Georgia Trakada, Lemonia Veletza, Theodora Tsiouda, Nikolaos Barbetakis, Dimitrios Paliouras, Evangelia Athanasiou, Dimitris Hatzibougias, Anastasios Kallianos, Nikolaos Panagiotopoulos, Liana Papaemmanouil, Wolfgang Hohenforst-Schmidt
Endobronchial ultrasound endoscopy is a state of the art diagnostic endoscopic procedure for the thorax. Firstly it was designed mainly for the staging of lung cancer and of course for the diagnosis of suspicious findings in large central airways. The main limitation of the equipment is the diameter of the instrument and therefore it can only be guided through large airways. However; the diameter of the working channel also provides a large tissue sample nowadays with the 19G biopsy needle. We will provide our experience with the 22G needle of the endobronchial convex-probe in several medical situations of the thorax...
2017: Respiratory Medicine Case Reports
https://www.readbyqxmd.com/read/28879074/a-case-report-of-egfr-mutant-lung-adenocarcinoma-that-acquired-resistance-to-egfr-tyrosine-kinase-inhibitors-with-t790m-mutation-and-epithelial-to-mesenchymal-transition
#11
Nana Zhang, Depu Wang, Xiaofeng Li, Zhe Yang, Guanjun Zhang, Yili Wang, Chunbao Wang
Although a secondary mutation and the epithelial-to-mesenchymal transition (EMT) are encountered very often in patients received the EGFR-TKI targeted treatment. The entire detrimental morphological change of the cancer entity was rare reported. Herein we report a case that acquired resistance to EGFR-TKI with T790M mutation and complete EMT morphological change of the tumor tissue. The primary lung tumor from a 52-year-old woman was diagnosed with moderate differentiated adenocarcinoma, with intensively positiveTTF-1 and E-cadherin in differentiated glandular structure but not the budding cancer cell cluster which with an intensive Vimentin staining...
2017: Respiratory Medicine Case Reports
https://www.readbyqxmd.com/read/28861334/severe-pneumocystis-jiroveci-pneumonia-in-a-patient-on-temozolomide-therapy-a-case-report-and-review-of-literature
#12
Babar Ahmad Khan, Sania Khan, Benjamin White, Ambika Eranki
A 66 year old man was diagnosed with CNS diffuse large B-cell lymphoma, and underwent treatment with Temozolomide, Dexamethasone, Rituximab, and radiation therapy, and prolonged steroid taper with Dexamethasone. Approximately one month after this, he presented with severe acute hypoxemic respiratory failure, and was admitted to the Medical Intensive Care Unit. Imaging showed diffuse ground glass opacities. Patient underwent diagnostic bronchoalveolar lavage which was positive for Pneumocystis jiroveci. He did not respond well to appropriate therapy and was transitioned to comfort care per his family's wishes, and expired...
2017: Respiratory Medicine Case Reports
https://www.readbyqxmd.com/read/28861333/successful-treatment-of-limited-stage-small-cell-lung-cancer-in-the-right-mainstem-bronchus-by-a-combination-of-chemotherapy-and-argon-plasma-coagulation
#13
Takayuki Takeda, Hideki Itano, Mayumi Takeuchi, Yurika Nishimi, Masahiko Saitoh, Sorou Takeda
The current standard-of-care treatment for patients with limited-stage small-cell lung cancer (SCLC) is concurrent chemoradiotherapy for local and systemic control. However, standard-of-care treatment strategies have not been established for those with limited-stage SCLC who have a history of thoracic radiotherapy due to concerns with complications associated with radiation overdose. A 37-year-old male developed an aspergilloma in the postoperative left thoracic space after he was treated with concurrent chemoradiotherapy for mediastinal type lung adenocarcionoma and subsequent left upper lobectomy for heterochronous dual adenocarcinoma...
2017: Respiratory Medicine Case Reports
https://www.readbyqxmd.com/read/28861332/eml4-alk-positive-lung-adenocarcinoma-presenting-an-unusual-metastatic-pattern-in-a-29-year-old-woman-who-is-alive-and-well%C3%A2-in%C3%A2-her-third-year-follow-up-a-case-report
#14
Fatma Tokat, Handan Zeren, Pinar Barut, Sualp Tansan, Umit Ince
Non-small cell lung cancer (NSCLC) is a frequent tumor entity with high mortality. Although several newly discovered chromosomal translocations and mutations opened new horizons for targeted therapy, literature still lacks large series of NSCLC with chromosomal abberations and their correlations with histological and clinical features. We present a case of echinoderm microtubule-associated protein-like 4-anaplastic lymphoma kinase (EML4-ALK) translocation positive adenocarcinoma of the lung with an unusual metastatic pattern in a 29-year-old young woman...
2017: Respiratory Medicine Case Reports
https://www.readbyqxmd.com/read/28856090/a-case-of-relapsed-lung-abscess-caused-by-eubacterium-brachy-infection-following-an-initial-diagnosis-of-pulmonary-actinomycosis
#15
Hideaki Yamakawa, Eri Hagiwara, Masahiro Hayashi, Takuma Katano, Kosuke Isomoto, Ryota Otoshi, Ryota Shintani, Satoshi Ikeda, Kaori Tanaka, Takashi Ogura
We report a rare case of lung abscess due to Eubacterium brachy. In this case, an analysis of the aspirate from frank pus revealed Gram-positive coccobacilli. We initially strongly suspected lung abscess associated with actinomycosis because of the chronic/recurrent clinical course and radio-pathological findings such as a granuloma lesion. Although a biochemical analysis revealed Actinomyces sp., 16S rRNA gene sequencing and a phylogenetic tree analysis of the isolated strain confirmed the presence of E. brachy...
2017: Respiratory Medicine Case Reports
https://www.readbyqxmd.com/read/28856089/plexogenic-pulmonary-hypertension-associated-with-poems-syndrome
#16
Thomas Czeczok, Peter Lin, Eunhee Yi
Pulmonary hypertension is one of the well-known clinical manifestations of polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes (POEMS) syndrome, occurring in approximately 25-30% of the affected individuals. However, the histopathologic spectrum of pulmonary hypertension associated with POEMS syndrome has not been fully documented in the literature. Herein, we report an autopsy case of POEMS syndrome in a patient whose lung tissues showed histopathology indistinguishable from that of idiopathic pulmonary arterial hypertension with abundant plexiform lesions in the small pulmonary arteries...
2017: Respiratory Medicine Case Reports
https://www.readbyqxmd.com/read/28856088/syndrome-of-inappropriate-secretion-of-anti-diuretic-hormone-siadh-as-an-initial-presenting-sign-of-non-small-cell-lung-cancer-case-report-and-literature-review
#17
Praneet Iyer, Mohammad Ibrahim, Waqas Siddiqui, Ahmed Dirweesh
Association of SIADH with malignancy was first reported in 1957, when it was described in two patients with bronchogenic carcinoma. While the association with small cell lung cancer (SCLC) is well known, that with non small cell lung cancer (NSCLC) has been rarely reported. We report a case of 70 year old male who was found to have hyponatremia secondary to SIADH. Radiological tests revealed right hilar lung mass with mediastinal adenopathy. Bronchoscopic biopsy revealed non-small cell lung cancer of type squamous cell...
2017: Respiratory Medicine Case Reports
https://www.readbyqxmd.com/read/28840097/a-case-of-delayed-exacerbation-of-interstitial-lung-disease-after-discontinuation-of-temsirolimus
#18
Rei Matsuki, Kenichi Okuda, Akihisa Mitani, Yasuhiro Yamauchi, Goh Tanaka, Haruki Kume, Yukio Homma, Munetoshi Hinata, Akimasa Hayashi, Junji Shibahara, Masashi Fukayama, Takahide Nagase
Temsirolimus is an inhibitor of mammalian target of rapamycin and interstitial lung disease (ILD) is known to be one of the adverse events associated with temsirolimus, which usually improves rapidly after discontinuation of the drug and rarely worsens thereafter. Herein, we report a case of delayed exacerbation of ILD after discontinuation of temsirolimus for metastatic renal cell carcinoma in an 86-year-old male with chronic ILD. The patient developed gradually worsening dyspnea five weeks after an initiation of temsirolimus and was admitted to our facility...
2017: Respiratory Medicine Case Reports
https://www.readbyqxmd.com/read/28831375/airway-fibroepithelial-polyposis
#19
Gonzalo Labarca, Ivan Caviedes, Macarena R Vial, Yumay Pires, Erik Folch, Adnan Majid, Sebastian Fernandez-Bussy
Fibroepithelial polyps are benign lesions, frequently found in the skin and genitourinary tract. Airway involvement is rare, and few case reports have been published. Our patient was a 79 y.o. male smoker, who was referred to us with a 3-month history of dry cough. At physical examination, the patient looked well, but a chest CT showed a 6-mm polyp lesion in his trachea. A flexible bronchoscopy confirmed this lesion, and forceps biopsies were performed. Argon plasma coagulation was used to completely resect and treat the lesion...
2017: Respiratory Medicine Case Reports
https://www.readbyqxmd.com/read/28831374/diffuse-pulmonary-infiltrates-a-guise-of-adenocarcinoma
#20
Mourad Ismail, Raminderjit Sekhon
Small and non-small cell lung cancer present in a variety of radiologic and clinical patterns, and have been linked to smoking. Primary adenocarcinoma of the lung has been increasingly recognized in females and nonsmokers, often presenting a diagnostic challenge. In the absence of smoking history, these radiographic patterns may be initially misdiagnosed as an infectious or inflammatory condition, often delaying the diagnosis of malignancy. We report two cases of female patients with relatively short or no smoking history presenting with diffuse pulmonary infiltrates not typically seen in primary lung cancer, which created a diagnostic challenge, ultimately diagnosed as primary lung adenocarcinoma...
2017: Respiratory Medicine Case Reports
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