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Emerging Microbes & Infections

Yan He, Linghua Li, Fengyu Hu, Wanshan Chen, Huali Lei, Xiejie Chen, Weiping Cai, Xiaoping Tang
Phospholipase B is a virulence factor for several clinically important pathogenic fungi, including Candida albicans, Cryptococcus neoformans and Aspergillus fumigatus, but its role in the thermally dimorphic fungus Talaromyces marneffei remains unclear. Here, we provide the first report of the expression of a novel phospholipase gene, designated TmPlb1, from T. marneffei in the eukaryotic expression system of Pichia pastoris GS115. Sensitive real-time quantitative reverse-transcription PCR (qRT-PCR) demonstrated that the expression of TmPlb1 increased 1...
November 23, 2016: Emerging Microbes & Infections
Yanke Liu, Wenyan Wan, Dongsheng Gao, Yongtao Li, Xia Yang, Hongying Liu, Huixia Yao, Lu Chen, Chuanqing Wang, Jun Zhao
Since May 2015, severe outbreaks of hepatitis-hydropericardium syndrome (HHS) associated with infections of fowl aviadenovirus (FAdV) have emerged in broiler chickens in several Chinese provinces. To identify the genotype and gain a better understanding of the genetic properties of the FAdV strains responsible for the recent HHS outbreaks in China, the complete genome sequences of five isolates from outbreaks of HHS in broiler chickens in five provinces were determined. The results demonstrated that a novel fowl aviadenovirus 4 (FAdV-4) genotype was epidemic in China...
November 23, 2016: Emerging Microbes & Infections
Feixue Wei, Kai Yin, Xin Wu, Jian Lan, Shoujie Huang, Wei Sheng, Jun Zhao, Yingying Su, Ying Wang, Yanping Li, Rongcheng Li, Jun Zhang, Mingqiang Li, Ting Wu, Ningshao Xia
Oncogenic human papillomavirus (HPV) infection is a cause of many anogenital cancers in women and men; however, there is little research on HPV prevalence and risk factors that includes both women and men from the same population. A total of 4687 participants, including 2378 women and 2309 men aged 18-55 years old from the same community, were enrolled in the study in Liuzhou, China. Exfoliated cells were collected from the participants from different anatomic sites and were tested for 13 oncogenic and 3 non-oncogenic HPV types...
November 23, 2016: Emerging Microbes & Infections
Shangshang Qin, Mengmeng Zhou, Qijing Zhang, Hengxun Tao, Yafei Ye, Huizhi Chen, Lijuan Xu, Hui Xu, Ping Wang, Xianju Feng
No abstract text is available yet for this article.
November 23, 2016: Emerging Microbes & Infections
Zoltán Palicz, Tamás Gáll, Éva Leiter, Sándor Kollár, Ilona Kovács, Kornél Miszti-Blasius, István Pócsi, László Csernoch, Péter Szentesi
PAF, a small antifungal protein from Penicillium chrysogenum, inhibits the growth of several pathogenic filamentous fungi, including members of the Aspergillus genus. PAF has been proven to have no toxic effects in vivo in mice by intranasal application. To test its efficacy against invasive pulmonary aspergillosis (IPA), experiments were carried out in mice suffering from IPA. Adult mice were immunosuppressed and then infected with Aspergillus fumigatus. After stable infection, the animals were inoculated with PAF intranasally at a concentration of 2...
November 9, 2016: Emerging Microbes & Infections
Chen Gao, Jing Wei, Bao-Yun Zhang, Qiang Shi, Cao Chen, Jing Wang, Qi Shi, Xiao-Ping Dong
MicroRNA (miRNA) is a class of non-coding endogenous small-molecule single-stranded RNA that regulates complementary mRNA through degradation or translation of the mRNA targets. Usually, miRNAs show remarkable cell and tissues specificity. Recently, alterations in a set of miRNAs in the brains of patients with certain neurodegenerative diseases, including prion diseases, have been reported. In this study, using deep sequencing technology, miRNA expression profiles in the brains of mice infected with scrapie agents 139A, ME7 and S15 at a terminal stage were comparatively analysed...
November 9, 2016: Emerging Microbes & Infections
Wei Sun, Rebecca A Weingarten, Miao Xu, Noel Southall, Sheng Dai, Paul Shinn, Philip E Sanderson, Peter R Williamson, Karen M Frank, Wei Zheng
Current antimicrobial susceptibility testing has limited screening capability for identifying empirical antibiotic combinations to treat severe bacterial infections with multidrug-resistant (MDR) organisms. We developed a new antimicrobial susceptibility assay using automated ultra-high-throughput screen technology in combination with a simple bacterial growth assay. A rapid screening of 5170 approved drugs and other compounds identified 25 compounds with activities against MDR Klebsiella pneumoniae. To further improve the efficacy and reduce the effective drug concentrations, we applied a targeted drug combination approach that integrates drugs' clinical antimicrobial susceptibility breakpoints, achievable plasma concentrations, clinical toxicities and mechanisms of action to identify optimal drug combinations...
November 9, 2016: Emerging Microbes & Infections
Wenling Wang, Huijuan Wang, Yao Deng, Tie Song, Jiaming Lan, Guizhen Wu, Changwen Ke, Wenjie Tan
The first imported case of Middle East respiratory syndrome (MERS) in China recently occurred, allowing for the characterization of antibody titers in a series of the patient's sera using the following methods based on recombinant viral structural antigens: inactivated MERS coronavirus (MERS-CoV) enzyme-linked immunosorbent assay (ELISA), recombinant MERS-CoV spike (S, or fragments of S) ELISA, nucleoprotein (NP) ELISA and MERS S pseudovirus particle-based neutralization test (ppNT). A longitudinal profile of the infection showed that seroconversion detected by ELISAs based on the recombinant extracellular domain, S, S1 and receptor-binding domain (RBD) antigens occurred as early as neutralizing antibodies were detected by the ppNT and earlier than antibodies were detected by the inactivated MERS-CoV and N-terminal domain (NTD) ELISAs...
November 9, 2016: Emerging Microbes & Infections
Shuai Yao, Tianbei Tuo, Xiang Gao, Chunyan Han, You Li, Yulong Gao, Yanping Zhang, Changjun Liu, Xiaole Qi, Honglei Gao, Yongqiang Wang, Xiaomei Wang
No abstract text is available yet for this article.
October 26, 2016: Emerging Microbes & Infections
Hong Liu, Liang Shen, Xiao-Lin Zhang, Xiao-Long Li, Guo-Dong Liang, Hong-Fang Ji
No abstract text is available yet for this article.
October 26, 2016: Emerging Microbes & Infections
Liqun Zhang, Yu Pang, Xia Yu, Yufeng Wang, Jie Lu, Mengqiu Gao, Hairong Huang, Yanlin Zhao
Pulmonary cavitation is one of the most frequently observed clinical characteristics in tuberculosis (TB). The objective of this study was to investigate the potential risk factors associated with cavitary TB in China. A total of 385 smear-positive patients were enrolled in the study, including 192 (49.9%) patients with cavitation as determined by radiographic findings. Statistical analysis revealed that the distribution of patients with diabetes in the cavitary group was significantly higher than that in the non-cavitary group (adjusted odds ratio (OR) (95% confidence interval (CI)):12...
October 12, 2016: Emerging Microbes & Infections
Azeem Mehmood Butt, Izza Nasrullah, Raheel Qamar, Yigang Tong
The codon usage patterns of viruses reflect the evolutionary changes that allow them to optimize their survival and adapt their fitness to the external environment and, most importantly, their hosts. Here we report the genotype-specific codon usage patterns of Zika virus (ZIKV) strains from the current and previous outbreaks. Several genotype-specific and common codon usage traits were noted in the ZIKV coding sequences, indicating their independent evolutionary origins from a common ancestor. The overall influence of natural selection was more profound than that of mutation pressure, acting on a specific set of viral genes in the Asian-genotype ZIKV strains from the recent outbreak...
October 12, 2016: Emerging Microbes & Infections
Jilei Zhang, Patrick John Kelly, Guangwu Lu, Luis Cruz-Martinez, Chengming Wang
No abstract text is available yet for this article.
October 12, 2016: Emerging Microbes & Infections
Yishi Xu, Carla Bianca Luena Victorio, Qimei Ng, Mookkan Prabakaran, Yee-Joo Tan, Kaw Bing Chua
The Saffold virus (SAFV) genome is translated as a single long polyprotein precursor and co-translationally cleaved to yield 12 separate viral proteins. Little is known about the activities of SAFV proteins although their homologs in other picornaviruses have already been described. To further support research on functions and activities of respective viral proteins, we investigated the spatio-temporal distribution of SAFV proteins in Vero and HEp-2 cells that had been either transfected with plasmids that express individual viral proteins or infected with live SAFV...
October 12, 2016: Emerging Microbes & Infections
Giovanni Di Guardo, Patrícia Baleeiro Beltrão Braga, Jean Pierre Schatzmann Peron
No abstract text is available yet for this article.
September 21, 2016: Emerging Microbes & Infections
Veasna Duong, Channa Mey, Marc Eloit, Huachen Zhu, Lucie Danet, Zhong Huang, Gang Zou, Arnaud Tarantola, Justine Cheval, Philippe Perot, Denis Laurent, Beat Richner, Santy Ky, Sothy Heng, Sok Touch, Ly Sovann, Rogier van Doorn, Thanh Tan Tran, Jeremy J Farrar, David E Wentworth, Suman R Das, Timothy B Stockwell, Jean-Claude Manuguerra, Francis Delpeyroux, Yi Guan, Ralf Altmeyer, Philippe Buchy
Human enterovirus 71 (EV-A71) causes hand, foot and mouth disease (HFMD). EV-A71 circulates in many countries and has caused large epidemics, especially in the Asia-Pacific region, since 1997. In April 2012, an undiagnosed fatal disease with neurological involvement and respiratory distress occurred in young children admitted to the Kantha Bopha Children's Hospital in Phnom Penh, Cambodia. Most died within a day of hospital admission, causing public panic and international concern. In this study, we describe the enterovirus (EV) genotypes that were isolated during the outbreak in 2012 and the following year...
September 21, 2016: Emerging Microbes & Infections
Samuel Cordey, Francisco Brito, Diem-Lan Vu, Lara Turin, Mary Kilowoko, Esther Kyungu, Blaise Genton, Evgeny M Zdobnov, Valérie D'Acremont, Laurent Kaiser
No abstract text is available yet for this article.
September 7, 2016: Emerging Microbes & Infections
Min Chen, Abdullah Ms Al-Hatmi, Yuchong Chen, Yang Ying, Wenjie Fang, Jianping Xu, Ferry Hagen, Nan Hong, Teun Boekhout, Wanqing Liao, Weihua Pan
No abstract text is available yet for this article.
September 7, 2016: Emerging Microbes & Infections
Hon S Ip, Jeffrey M Lorch, David S Blehert
Global translocation of plants and animals is a well-recognized mechanism for introduction of pathogens into new regions. To mitigate this risk, various tools such as preshipment health certificates, quarantines, screening for specific disease agents and outright bans have been implemented. However, such measures only target known infectious agents and their hosts and may fail to prevent translocation of even well-recognized pathogens if they are carried by novel host species. In a recent example, we screened an imported shipment of Chinese firebelly newts (Cynops orientalis) for Batrachochytrium salamandrivorans, an emergent fungal pathogen of salamanders...
September 7, 2016: Emerging Microbes & Infections
Wenjie Fang, Min Chen, Jia Liu, Ferry Hagen, Abdullah Ms, Al-Hatmi, Peilian Zhang, Yun Guo, Teun Boekhout, Danqi Deng, Jianping Xu, Weihua Pan, Wanqing Liao
Cryptococcal meningitis is an important fungal infection among systemic lupus erythematosus patients. We conducted a pooled analysis and systematic review to describe the epidemiological and clinical profile of cryptococcal meningitis in systemic lupus erythematosus patients. From two hospitals in China and nine literature databases, cases and prevalence data were collected for pooled analysis and meta-analysis, respectively. Categorical variables of cases were compared using a χ(2)-test on the statistical program of SAS...
September 7, 2016: Emerging Microbes & Infections
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