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Emerging Microbes & Infections

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https://www.readbyqxmd.com/read/28698668/salmonella-enterica-serovar-typhimurium-st34-co-expressing-blandm-5-and-blactx-m-55-isolated-in-china
#1
Lang Yang, Xiaofeng Hu, Xuebin Xu, Chaojie Yang, Jing Xie, Rongzhang Hao, Xinying Du, Ligui Wang, Leili Jia, Peng Li, Shaofu Qiu, Hongbin Song
No abstract text is available yet for this article.
July 12, 2017: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/28698667/phylogenetic-analysis-reveals-two-genotypes-of-the-emerging-fungus-mucor-indicus-an-opportunistic-human-pathogen-in-immunocompromised-patients
#2
Saad J Taj-Aldeen, Muna Almaslamani, Bart Theelen, Teun Boekhout
Mucormycosis is a rare fungal infection caused by Mucor indicus. Phylogenetic analysis of many M. indicus isolates, mainly sampled from different clinical and environmental specimens collected worldwide, revealed two genotypes, I and II, based on ITS and D1/D2 LSU rDNA sequences. A retrospective review of the literature revealed 13 cases. Eight (76.9%) patients had disseminated infections, and the overall mortality rate was 30.7%. A pulmonary infection caused by M. indicus genotype I in a liver transplant recipient was disseminated to include the skin and was successfully treated with liposomal amphotericin B and aggressive surgery...
July 12, 2017: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/28698666/modelling-person-to-person-transmission-in-an-enterovirus-a71-orally-infected-hamster-model-of-hand-foot-and-mouth-disease-and-encephalomyelitis
#3
Win Kyaw Phyu, Kien Chai Ong, Kum Thong Wong
Enterovirus A71 (EV-A71) causes hand-foot-and-mouth disease (HFMD), which may be complicated by fatal encephalomyelitis. Although fecal-oral or oral-oral routes are important in person-to-person transmission, how viral shedding and exposure may predispose individuals to infection remains unknown. We investigated person-to-person transmission by using a model of HFMD and encephalomyelitis based on EV-A71 oral infection of 2-week-old hamsters. Animals (index animals) infected with 10(4) 50% cell culture infective doses of virus uniformly developed severe disease four days post-infection (dpi), whereas littermate contacts developed severe disease after six to seven days of exposure to index animals...
July 12, 2017: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/28698665/antigens-rv0310c-and-rv1255c-are-promising-novel-biomarkers-for-the-diagnosis-of-mycobacterium-tuberculosis-infection
#4
Liulin Luo, Lin Zhu, Jun Yue, Jianping Liu, Guoyuan Liu, Xuelian Zhang, Honghai Wang, Ying Xu
This study aimed to identify novel immunogenic epitopes from Mycobacterium tuberculosis (MTB) that could be used in tuberculosis (TB) diagnostics. To determine the diagnostic potential of mycobacterial antigens in serodiagnosis of TB, 256 patients were enrolled in a study and divided into two groups: 126 smear-positive pulmonary TB patients (SPPT) and 130 smear-negative pulmonary TB patients (SNPT); 152 bacillus Calmette-Guerin (BCG)-vaccinated healthy people were used as a control. Murine results showed that antigens Rv0310c-E from RD 8 and Rv1255c-E from RD 10 were strongly immunogenic to Th1 cells and induced a great humoral response...
July 12, 2017: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/28655936/a-novel-neutralizing-monoclonal-antibody-targeting-the-n-terminal-domain-of-the-mers-cov-spike-protein
#5
Yingzhu Chen, Shuai Lu, Hao Jia, Yao Deng, Jianfang Zhou, Baoying Huang, Yueyang Yu, Jiaming Lan, Wenling Wang, Yongliang Lou, Kun Qin, Wenjie Tan
This corrects the article DOI: 10.1038/emi.2017.18.
June 28, 2017: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/28634359/infections-of-horses-and-shrews-with-bornaviruses-in-upper-austria-a-novel-endemic-area-of-borna-disease
#6
Herbert Weissenböck, Zoltán Bagó, Jolanta Kolodziejek, Barbara Hager, Günter Palmetzhofer, Ralf Dürrwald, Norbert Nowotny
Borna disease, a lethal infection with Borna disease virus-1 (BoDV-1), was diagnosed in four horses from Upper Austria in 2015 and 2016. All cases occurred in winter (two cases in February 2015 and two cases in December 2016), and the maximal distance of the affected stables was 17 km. To demonstrate whether the causative agent was also harbored by its reservoir host, the bicolored white-toothed shrew (Crocidura leucodon), 28 shrews from this geographic area were collected in 2015 and investigated for the presence of BoDV-1...
June 21, 2017: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/28634358/hiv-1-gp41-targeting-fusion-inhibitory-peptides-enhance-the-gp120-targeting-protein-mediated-inactivation-of-hiv-1-virions
#7
Qianqian Qi, Qian Wang, Weizao Chen, Lanying Du, Dimiter S Dimitrov, Lu Lu, Shibo Jiang
Protein- or peptide-based viral inactivators are being developed as novel antiviral drugs with improved efficacy, pharmacokinetics and toxicity profiles because they actively inactivate cell-free human immunodeficiency virus type 1 (HIV-1) virions before attachment to host cells. By contrast, most clinically used antiviral drugs must penetrate host cells to inhibit viral replication. In this study, we pre-treated HIV-1 particles with a gp120-targeting bispecific multivalent protein, 2Dm2m or 4Dm2m, in the presence or absence of the gp41-targeting HIV-1 fusion inhibitory peptides enfuvirtide (T20), T2635, or sifuvirtide (SFT)...
June 21, 2017: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/28634357/astroviruses-in-bats-madagascar
#8
Camille Lebarbenchon, Beza Ramasindrazana, Léa Joffrin, Sandra Bos, Erwan Lagadec, Gildas Le Minter, Yann Gomard, Pablo Tortosa, David A Wilkinson, Steven M Goodman, Patrick Mavingui
No abstract text is available yet for this article.
June 21, 2017: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/28634356/an-outbreak-of-echovirus-18-encephalitis-meningitis-in-children-in-hebei-province-china-2015
#9
Xiangpeng Chen, Jingjie Li, Jiayun Guo, Wenbo Xu, Suzhen Sun, Zhengde Xie
No abstract text is available yet for this article.
June 21, 2017: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/28634355/longitudinal-study-of-middle-east-respiratory-syndrome-coronavirus-infection-in-dromedary-camel-herds-in-saudi-arabia-2014-2015
#10
Maged Gomaa Hemida, Abdulmohsen Alnaeem, Daniel Kw Chu, Ranawaka Apm Perera, Samuel Ms Chan, Faisal Almathen, Emily Yau, Brian Cy Ng, Richard J Webby, Leo Lm Poon, Malik Peiris
Two herds of dromedary camels were longitudinally sampled with nasal and rectal swabs and serum, between September 2014 and May 2015, and the samples were tested for Middle East Respiratory Syndrome (MERS) coronavirus RNA and antibodies. Evidence of MERS-CoV infection was confirmed in one herd on the basis of detection of virus RNA in nasal swabs from three camels and significant increases in the antibody titers from three others. The three viruses were genetically identical, thus indicating introduction of a single virus into this herd...
June 21, 2017: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/28634354/primary-osteomyelitis-caused-by-an-ndm-1-producing-k-pneumoniae-strain-of-the-highly-virulent-sequence-type-23
#11
Fabrice Compain, Alexis Vandenberghe, Marie Gominet, Nathalie Genel, David Lebeaux, Astrid Ramahefasolo, Isabelle Podglajen, Dominique Decré
No abstract text is available yet for this article.
June 21, 2017: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/28634353/coronavirus-hku15-in-respiratory-tract-of-pigs-and-first-discovery-of-coronavirus-quasispecies-in-5-untranslated-region
#12
Patrick Cy Woo, Susanna Kp Lau, Chi-Ching Tsang, Candy Cy Lau, Po-Chun Wong, Franklin Wn Chow, Jordan Yh Fong, Kwok-Yung Yuen
Coronavirus HKU15 is a deltacoronavirus that was discovered in fecal samples of pigs in Hong Kong in 2012. Over the past three years, Coronavirus HKU15 has been widely detected in pigs in East/Southeast Asia and North America and has been associated with fatal outbreaks. In all such epidemiological studies, the virus was generally only detected in fecal/intestinal samples. In this molecular epidemiology study, we detected Coronavirus HKU15 in 9.6% of the nasopharyngeal samples obtained from 249 pigs in Hong Kong...
June 21, 2017: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/28634352/differences-in-sequences-between-hbv-relaxed-circular-dna-and-covalently-closed-circular-dna
#13
Magda Rybicka, Anna Woziwodzka, Tomasz Romanowski, Piotr Stalke, Marcin Dręczewski, Krzysztof Piotr Bielawski
The hepatitis B virus (HBV) genome exists in two forms: circular covalently closed DNA (cccDNA) and relaxed circular DNA (RCDNA). Here, we investigated the presence of differences in the sequences of both forms in paired samples of serum and liver tissue. The serum and liver biopsy samples were collected at the same time from 67 chronically infected patients. The genotyping of the RCDNA and cccDNA was performed using mass spectrometry analysis. The HBV mutations located in the HBV pol (P) and the HBV basal core promoter/pre-core (BCP/PC) regions were included...
June 21, 2017: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/28588294/predictors-of-seropositivity-for-human-herpesvirus-type-8-in-patients-with-mild-cirrhosis
#14
Kuo-Chih Tseng, Ming-Nan Lin, Tang-Yuan Chu, Jen-Pi Tsai, Cheng-Chuan Su
The high seroprevalence of human herpesvirus type 8 (HHV-8) in moderate or severe cirrhotics appears to be associated with male sex, hepatitis B virus (HBV) infection, alcoholism, and disease severity. The status of HHV-8 infection in mild cirrhotics remains unclear. Plasma samples collected from 93 mild cirrhotics and 93 age- and sex-matched healthy controls were analyzed for HHV-8 antibody and HHV-8 DNA. Mild cirrhotics had higher seropositivity for HHV-8 antibodies than healthy controls (P=0.0001). Univariate logistic regression analysis revealed that an age ≥55 years (odds ratio (OR) 2...
June 7, 2017: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/28588293/human-infections-with-novel-reassortant-h5n6-avian-influenza-viruses-in-china
#15
Ye Zhang, Minmei Chen, Yiwei Huang, Wenfei Zhu, Lei Yang, Lidong Gao, Xiaodan Li, Fuyin Bi, Chaoyang Huang, Ning Kang, Hengjiao Zhang, Zi Li, Hong Bo, Dayan Wang, Yuelong Shu
No abstract text is available yet for this article.
June 7, 2017: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/28588292/recombinant-feline-parvovirus-infection-of-immunized-tigers-in-central-china
#16
Xingang Wang, Tongyi Li, Hongying Liu, Jimei Du, Feng Zhou, Yanming Dong, Xiuyuan He, Yongtao Li, Chuanqing Wang
No abstract text is available yet for this article.
June 7, 2017: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/28588291/seroprevalence-of-neutralizing-antibodies-against-adenovirus-type-14-and-55-in-healthy-adults-in-southern-china
#17
Xuehua Zheng, Xia Rong, Ying Feng, Xikui Sun, Liang Li, Qian Wang, Min Wang, Wenkuan Liu, Chufang Li, Yiyu Yang, Rong Zhou, Jiahai Lu, Liqiang Feng, Ling Chen
Re-emerging human adenovirus types 14 (Ad14) and 55 (Ad55) have caused severe respiratory diseases and even deaths during recent outbreaks. However, the seroprevalence of neutralizing antibodies (nAbs) in healthy adults, which may reflect previous circulation and help to predict potential outbreaks, remains unclear. In this study, we established micro-neutralizing (MN) assays on the basis of recombinant Ad14 and Ad55 reporter viruses, and we investigated serum nAbs in healthy blood donors from Southern China...
June 7, 2017: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/28588290/comparative-epidemiology-of-middle-east-respiratory-syndrome-coronavirus-mers-cov-in-saudi-arabia-and-south-korea
#18
Xin Chen, Abrar Ahmad Chughtai, Amalie Dyda, Chandini Raina MacIntyre
MERS-CoV infection emerged in the Kingdom of Saudi Arabia (KSA) in 2012 and has spread to 26 countries. However, 80% of all cases have occurred in KSA. The largest outbreak outside KSA occurred in South Korea (SK) in 2015. In this report, we describe an epidemiological comparison of the two outbreaks. Data from 1299 cases in KSA (2012-2015) and 186 cases in SK (2015) were collected from publicly available resources, including FluTrackers, the World Health Organization (WHO) outbreak news and the Saudi MOH (MOH)...
June 7, 2017: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/28588289/west-nile-virus-infection-in-suspected-febrile-typhoid-cases-in-xinjiang-china
#19
Lei Cao, Shihong Fu, Zhi Lv, Chengjun Tang, Shiheng Cui, Xiaolong Li, Xiaoyan Gao, Minghua Li, Yuxi Cao, Wenwen Lei, Ying He, Huanyu Wang, Guodong Liang
No abstract text is available yet for this article.
June 7, 2017: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/28588288/t-cell-dependent-mechanisms-promote-ebola-vlp-induced-antibody-responses-but-are-dispensable-for-vaccine-mediated-protection
#20
Christopher L Cooper, Karen A Martins, Sabrina M Stronsky, David P Langan, Jesse Steffens, Sean Van Tongeren, Sina Bavari
Humoral responses are essential for the protective efficacy of most Ebola virus (EBOV) candidate vaccines; however, the in vivo development of protective anti-EBOV B-cell responses is poorly defined. Here, by using the virus-like particle (VLP) as a model antigen, we demonstrate that humoral responses are generated through follicular B-cell and T-cell-dependent mechanisms in a mouse model of EBOV infection. In addition, we show that the inclusion of the clinical-grade dsRNA adjuvant known as poly-ICLC in VLP vaccinations both augments and sustains germinal center B-cell reactions, antigen-specific B-cell frequencies and anti-EBOV serum titers...
June 7, 2017: Emerging Microbes & Infections
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