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Emerging Microbes & Infections

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https://www.readbyqxmd.com/read/28325923/clinical-features-and-viral-quasispecies-characteristics-associated-with-infection-by-the-hepatitis-b-virus-g145r-immune-escape-mutant
#1
Yuan Xue, Ming-Jie Wang, Zhi-Tao Yang, De-Min Yu, Yue Han, Dao Huang, Dong-Hua Zhang, Xin-Xin Zhang
Coexistence of the hepatitis B surface antigen (HBsAg) and hepatitis B surface antibody (anti-HBs) is an uncommon phenomenon, and the underlying mechanisms remain largely unknown. Amino-acid (aa) substitution from glycine to arginine at aa 145 (G145R), in the major hydrophilic region, has been reported in patients with HBsAg and anti-HBs coexistence. However, there is limited knowledge about the clinical features and viral quasispecies characteristics associated with G145R mutant hepatitis B virus (HBV) infection...
March 22, 2017: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/28325922/variability-in-h9n2-haemagglutinin-receptor-binding-preference-and-the-ph-of-fusion
#2
Thomas P Peacock, Donald J Benton, Jean-Remy Sadeyen, Pengxiang Chang, Joshua E Sealy, Juliet E Bryant, Stephen R Martin, Holly Shelton, John W McCauley, Wendy S Barclay, Munir Iqbal
H9N2 avian influenza viruses are primarily a disease of poultry; however, they occasionally infect humans and are considered a potential pandemic threat. Little work has been performed to assess the intrinsic biochemical properties related to zoonotic potential of H9N2 viruses. The objective of this study, therefore, was to investigate H9N2 haemagglutinins (HAs) using two well-known correlates for human adaption: receptor-binding avidity and pH of fusion. Receptor binding was characterized using bio-layer interferometry to measure virus binding to human and avian-like receptor analogues and the pH of fusion was assayed by syncytium formation in virus-infected cells at different pHs...
March 22, 2017: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/28325921/zika-virus-genome-biology-and-molecular-pathogenesis
#3
REVIEW
Anyou Wang, Stephanie Thurmond, Leonel Islas, Kingyung Hui, Rong Hai
Zika virus (ZIKV) is an emerging RNA virus in the widespread Flavivirus genus. Recently, ZIKV has rapidly spread around the world and has been implicated in human disease, including neurological disorders, triggering public and scientific attention. Understanding how ZIKV causes disease is the highest priority, yet little is known about this virus. Here we examine the currently published data from ZIKV studies to provide the latest understanding of ZIKV genome biology and molecular pathogenesis. The ZIKV genome evolved rapidly from the Flavivirus genus and diverged from the members of this genus, even within the dengue virus cluster to which ZIKV belongs...
March 22, 2017: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/28270655/insight-into-live-bird-markets-of-bangladesh-an-overview-of-the-dynamics-of-transmission-of-h5n1-and-h9n2-avian-influenza-viruses
#4
Jasmine C M Turner, Mohammed M Feeroz, M Kamrul Hasan, Sharmin Akhtar, David Walker, Patrick Seiler, Subrata Barman, John Franks, Lisa Jones-Engel, Pamela McKenzie, Scott Krauss, Richard J Webby, Ghazi Kayali, Robert G Webster
Highly pathogenic avian influenza (HPAI) H5N1 and low pathogenic avian influenza (LPAI) H9N2 viruses have been recognized as threats to public health in Bangladesh since 2007. Although live bird markets (LBMs) have been implicated in the transmission, dissemination, and circulation of these viruses, an in-depth analysis of the dynamics of avian transmission of H5N1 and H9N2 viruses at the human-animal interface has been lacking. Here we present and evaluate epidemiological findings from active surveillance conducted among poultry in various production sectors in Bangladesh from 2008 to 2016...
March 8, 2017: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/28223683/metataxonomics-reveal-vultures-as-a-reservoir-for-clostridium-perfringens
#5
Xiangli Meng, Shan Lu, Jing Yang, Dong Jin, Xiaohong Wang, Xiangning Bai, Yumeng Wen, Yiting Wang, Lina Niu, Changyun Ye, Ramon Rosselló-Móra, Jianguo Xu
The Old World vulture may carry and spread pathogens for emerging infections since they feed on the carcasses of dead animals and participate in the sky burials of humans, some of whom have died from communicable diseases. Therefore, we studied the precise fecal microbiome of the Old World vulture with metataxonomics, integrating the high-throughput sequencing of almost full-length small subunit ribosomal RNA (16S rRNA) gene amplicons in tandem with the operational phylogenetic unit (OPU) analysis strategy...
February 22, 2017: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/28223682/environmental-surfaces-used-in-entry-day-corralling-likely-contribute-to-the-spread-of-influenza-a-virus-in-swine-at-agricultural-fairs
#6
Sarah E Lauterbach, Michele M Zentkovich, Sarah W Nelson, Jacqueline M Nolting, Andrew S Bowman
No abstract text is available yet for this article.
February 22, 2017: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/28196971/multilocus-sequence-typing-identifies-an-avian-like-chlamydia-psittaci-strain-involved-in-equine-placentitis-and-associated-with-subsequent-human-psittacosis
#7
LETTER
Martina Jelocnik, James Branley, Jane Heller, Shane Raidal, Susan Alderson, Francesca Galea, Melinda Gabor, Adam Polkinghorne
No abstract text is available yet for this article.
February 15, 2017: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/28196970/neonatal-pigs-are-susceptible-to-experimental-zika-virus-infection
#8
LETTER
Joseph Darbellay, Kenneth Lai, Shawn Babiuk, Yohannes Berhane, Aruna Ambagala, Colette Wheler, Donald Wilson, Stewart Walker, Andrew Potter, Matthew Gilmour, David Safronetz, Volker Gerdts, Uladzimir Karniychuk
No abstract text is available yet for this article.
February 15, 2017: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/28196969/mutation-in-clpc1-encoding-an-atp-dependent-atpase-involved-in-protein-degradation-is-associated-with-pyrazinamide-resistance-in-mycobacterium-tuberculosis
#9
LETTER
Shuo Zhang, Jiazhen Chen, Wanliang Shi, Peng Cui, Jia Zhang, Sanghyun Cho, Wenhong Zhang, Ying Zhang
No abstract text is available yet for this article.
February 15, 2017: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/28096532/a-sensitive-and-specific-point-of-care-detection-assay-for-zaire-ebola-virus
#10
LETTER
Xiao-Ai Zhang, Sabrina Li, Jesus Ching, Hui-Ying Feng, Kun Yang, David L Dolinger, Long-Di Zhang, Pan-He Zhang, Wei Liu, Wu-Chun Cao
No abstract text is available yet for this article.
January 18, 2017: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/28096531/the-first-imported-case-of-rift-valley-fever-in-china-reveals-a-genetic-reassortment-of-different-viral-lineages
#11
Jingyuan Liu, Yulan Sun, Weifeng Shi, Shuguang Tan, Yang Pan, Shujuan Cui, Qingchao Zhang, Xiangfeng Dou, Yanning Lv, Xinyu Li, Xitai Li, Lijuan Chen, Chuansong Quan, Qianli Wang, Yingze Zhao, Qiang Lv, Wenhao Hua, Hui Zeng, Zhihai Chen, Haofeng Xiong, Chengyu Jiang, Xinghuo Pang, Fujie Zhang, Mifang Liang, Guizhen Wu, George F Gao, William J Liu, Ang Li, Quanyi Wang
We report the first imported case of Rift Valley fever (RVF) in China. The patient returned from Angola, a non-epidemic country, with an infection of a new reassortant from different lineages of Rift Valley fever viruses (RVFVs). The patient developed multiorgan dysfunction and gradually recovered with continuous renal replacement therapy and a short regimen of methylprednisolone treatment. The disordered cytokines and chemokines in the plasma of the patient revealed hypercytokinemia, but the levels of protective cytokines were low upon admission and fluctuated as the disease improved...
January 18, 2017: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/28050022/an-isolate-of-vibrio-campbellii-carrying-the-pir-vp-gene-causes-acute-hepatopancreatic-necrosis-disease
#12
LETTER
Xuan Dong, Hailiang Wang, Guosi Xie, Peizhuo Zou, Chengcheng Guo, Yan Liang, Jie Huang
No abstract text is available yet for this article.
January 4, 2017: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/28050021/systematic-active-surveillance-for-middle-east-respiratory-syndrome-coronavirus-in-camels-in-egypt
#13
Mohamed A Ali, Mahmoud M Shehata, Mokhtar R Gomaa, Ahmed Kandeil, Rabeh El-Shesheny, Ahmed S Kayed, Ahmed N El-Taweel, Mohamed Atea, Nagla Hassan, Ola Bagato, Yassmin Moatasim, Sara H Mahmoud, Omnia Kutkat, Asmaa M Maatouq, Ahmed Osman, Pamela P McKenzie, Richard J Webby, Ghazi Kayali
Middle East respiratory syndrome coronavirus (MERS-CoV) causes severe human infections and dromedary camels are considered an intermediary host. The dynamics of natural infection in camels are not well understood. Through systematic surveillance in Egypt, nasal, rectal, milk, urine and serum samples were collected from camels between June 2014 and February 2016. Locations included quarantines, markets, abattoirs, free-roaming herds and farmed breeding herds. The overall seroprevalence was 71% and RNA detection rate was 15%...
January 4, 2017: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/28050020/identification-and-evolutionary-dynamics-of-two-novel-human-coronavirus-oc43-genotypes-associated-with-acute-respiratory-infections-phylogenetic-spatiotemporal-and-transmission-network-analyses
#14
Xiang Yong Oong, Kim Tien Ng, Yutaka Takebe, Liang Jie Ng, Kok Gan Chan, Jack Bee Chook, Adeeba Kamarulzaman, Kok Keng Tee
Human coronavirus OC43 (HCoV-OC43) is commonly associated with respiratory tract infections in humans, with five genetically distinct genotypes (A to E) described so far. In this study, we obtained the full-length genomes of HCoV-OC43 strains from two previously unrecognized lineages identified among patients presenting with severe upper respiratory tract symptoms in a cross-sectional molecular surveillance study in Kuala Lumpur, Malaysia, between 2012 and 2013. Phylogenetic, recombination and comparative genomic analyses revealed two distinct clusters diverging from a genotype D-like common ancestor through recombination with a putative genotype A-like lineage in the non-structural protein (nsp) 10 gene...
January 4, 2017: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/27999426/a-camel-derived-mers-cov-with-a-variant-spike-protein-cleavage-site-and-distinct-fusion-activation-properties
#15
Jean Kaoru Millet, Monty E Goldstein, Rachael N Labitt, Hung-Lun Hsu, Susan Daniel, Gary R Whittaker
Middle East respiratory syndrome coronavirus (MERS-CoV) continues to circulate in both humans and camels, and the origin and evolution of the virus remain unclear. Here we characterize the spike protein of a camel-derived MERS-CoV (NRCE-HKU205) identified in 2013, early in the MERS outbreak. NRCE-HKU205 spike protein has a variant cleavage motif with regard to the S2' fusion activation site-notably, a novel substitution of isoleucine for the otherwise invariant serine at the critical P1' cleavage site position...
December 21, 2016: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/27999425/first-documented-case-of-avian-influenza-h5n1-virus-infection-in-a-lion
#16
Quanjiao Chen, Hanzhong Wang, Lihua Zhao, Liping Ma, Runkun Wang, Yongsong Lei, Yong Li, Guoxiang Yang, Jing Chen, Guang Chen, Liqiang Li, Tao Jin, Jiandong Li, Xin Liu, Xun Xu, Gary Wong, Lei Liu, Yingxia Liu, Weifeng Shi, Yuhai Bi, George F Gao
No abstract text is available yet for this article.
December 21, 2016: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/27999424/polyphyletic-origin-of-mers-coronaviruses-and-isolation-of-a-novel-clade-a-strain-from-dromedary-camels-in-the-united-arab-emirates
#17
Susanna K P Lau, Renate Wernery, Emily Y M Wong, Sunitha Joseph, Alan K L Tsang, Nissy Annie Georgy Patteril, Shyna K Elizabeth, Kwok-Hung Chan, Rubeena Muhammed, Jöerg Kinne, Kwok-Yung Yuen, Ulrich Wernery, Patrick C Y Woo
Little is known regarding the molecular epidemiology of Middle East respiratory syndrome coronavirus (MERS-CoV) circulating in dromedaries outside Saudi Arabia. To address this knowledge gap, we sequenced 10 complete genomes of MERS-CoVs isolated from 2 live and 8 dead dromedaries from different regions in the United Arab Emirates (UAE). Phylogenetic analysis revealed one novel clade A strain, the first detected in the UAE, and nine clade B strains. Strain D998/15 had a distinct phylogenetic position within clade A, being more closely related to the dromedary isolate NRCE-HKU205 from Egypt than to the human isolates EMC/2012 and Jordan-N3/2012...
December 21, 2016: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/27999423/characterization-of-community-associated-staphylococcus-aureus-from-skin-and-soft-tissue-infections-a-multicenter-study-in-china
#18
MULTICENTER STUDY
Ying Liu, Zhe Xu, Zhou Yang, Juan Sun, Lin Ma
We evaluated the epidemiological and molecular features of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) and methicillin-sensitive S. aureus (MSSA) from children and adult patients with skin and soft-tissue infections (SSTIs) in China. Prospective community-acquired S. aureus SSTI surveillance was conducted in 23 hospitals over a 24-month period. Susceptibility to 16 antimicrobials was evaluated using the agar dilution method. StatApriori was used to determine statistically significant association trends...
December 21, 2016: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/27924811/insights-into-the-evolution-of-pathogenicity-of-escherichia-coli-from-genomic-analysis-of-intestinal-e-coli-of-marmota-himalayana-in-qinghai-tibet-plateau-of-china
#19
Shan Lu, Dong Jin, Shusheng Wu, Jing Yang, Ruiting Lan, Xiangning Bai, Sha Liu, Qiong Meng, Xuejiao Yuan, Juan Zhou, Ji Pu, Qiang Chen, Hang Dai, Yuanyuan Hu, Yanwen Xiong, Changyun Ye, Jianguo Xu
Escherichia coli is both of a widespread harmless gut commensal and a versatile pathogen of humans. Domestic animals are a well-known reservoir for pathogenic E. coli. However, studies of E. coli populations from wild animals that have been separated from human activities had been very limited. Here we obtained 580 isolates from intestinal contents of 116 wild Marmot Marmota himalayana from Qinghai-Tibet plateau, China, with five isolates per animal. We selected 125 (hereinafter referred to as strains) from the 580 isolates for genome sequencing, based on unique pulse field gel electrophoresis patterns and at least one isolate per animal...
December 7, 2016: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/27924810/consecutive-large-dengue-outbreaks-in-taiwan-in-2014-2015
#20
LETTER
Sheng-Fan Wang, Ko Chang, El-Wui Loh, Wen-Hung Wang, Sung-Pin Tseng, Po-Liang Lu, Yen-Hsu Chen, Yi-Ming Arthur Chen
No abstract text is available yet for this article.
December 7, 2016: Emerging Microbes & Infections
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