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Emerging Microbes & Infections

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https://www.readbyqxmd.com/read/28487561/crowdsourcing-based-nationwide-tick-collection-reveals-the-distribution-of-ixodes-ricinus-and-i-persulcatus-and-associated-pathogens-in-finland
#1
Maija Laaksonen, Eeva Sajanti, Jani J Sormunen, Ritva Penttinen, Jari Hänninen, Kai Ruohomäki, Ilari Sääksjärvi, Eero J Vesterinen, Ilppo Vuorinen, Jukka Hytönen, Tero Klemola
A national crowdsourcing-based tick collection campaign was organized in 2015 with the objective of producing novel data on tick distribution and tick-borne pathogens in Finland. Nearly 20 000 Ixodes ticks were collected. The collected material revealed the nationwide distribution of I. persulcatus for the first time and a shift northwards in the distribution of I. ricinus in Finland. A subset of 2038 tick samples containing both species was screened for Borrelia burgdorferi sensu lato (the prevalence was 14...
May 10, 2017: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/28487560/seroepidemiology-of-enterovirus-d68-infection-in-china
#2
Zichun Xiang, Linlin Li, Lili Ren, Li Guo, Zhengde Xie, Chunyan Liu, Taisheng Li, Ming Luo, Gláucia Paranhos-Baccalà, Wenbo Xu, Jianwei Wang
Human enterovirus 68 (EV-D68) is a rarely reported virus that has been linked to respiratory disease. In recent years, reports about EV-D68 infection have markedly increased worldwide. However, the epidemiological features of this emerging infection are not well understood. To evaluate the emerging EV-D68 epidemic, we isolated the circulating viral strain and investigated the seroprevalence of neutralizing antibodies (NAbs) in Beijing between 2004 and 2011. We found that the titers of EV-D68 NAbs were generally low in all age groups in sampled populations in 2004 but significantly higher in 2009...
May 10, 2017: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/28487559/global-and-local-environmental-changes-as-drivers-of-buruli-ulcer-emergence
#3
Marine Combe, Camilla Jensen Velvin, Aaron Morris, Andres Garchitorena, Kevin Carolan, Daniel Sanhueza, Benjamin Roche, Pierre Couppié, Jean-François Guégan, Rodolphe Elie Gozlan
No abstract text is available yet for this article.
May 10, 2017: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/28487558/full-genetic-characterization-and-epidemiology-of-a-novel-amdoparvovirus-in-striped-skunk-mephitis-mephitis
#4
Marta Canuti, Hillary E Doyle, Ann P Britton, Andrew S Lang
Amdoparvovirus is a newly defined parvoviral genus that contains four species (Carnivore amdoparvovirus 1-4), including the well-known Aleutian mink disease virus (AMDV). Amdoparvoviruses cause an immune-associated and often lethal wasting syndrome in Mustelidae and Caninae hosts. In this study, we molecularly investigated amdoparvoviruses detected in 44 striped skunks (Mephitis mephitis) found dead in and around Vancouver, British Columbia, Canada. Some of the animals exhibited pathological changes compatible with amdoparvovirus-associated disease...
May 10, 2017: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/28487557/humoral-cross-reactivity-between-zika-and-dengue-viruses-implications-for-protection-and-pathology
#5
REVIEW
Lalita Priyamvada, William Hudson, Rafi Ahmed, Jens Wrammert
Zika virus (ZIKV) is a re-emerging mosquito-borne flavivirus that has recently caused extensive outbreaks in Central and South America and the Caribbean. Given its association with Guillain-Barré syndrome in adults and neurological and ocular malformities in neonates, ZIKV has become a pathogen of significant public health concern worldwide. ZIKV shares a considerable degree of genetic identity and structural homology with other flaviviruses, including dengue virus (DENV). In particular, the surface glycoprotein envelope (E), which is involved in viral fusion and entry and is therefore a chief target for neutralizing antibody responses, contains regions that are highly conserved between the two viruses...
May 10, 2017: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/28487556/emergence-of-inti1-associated-blavim-2-gene-cassette-mediated-carbapenem-resistance-in-opportunistic-pathogen-pseudomonas-stutzeri
#6
Sabrin Bashar, Santonu Kumar Sanyal, Munawar Sultana, M Anwar Hossain
No abstract text is available yet for this article.
May 10, 2017: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/28442755/global-and-local-environmental-changes-as-drivers-of-buruli-ulcer-emergence
#7
REVIEW
Marine Combe, Camilla Jensen Velvin, Aaron Morris, Andres Garchitorena, Kevin Carolan, Daniel Sanhueza, Benjamin Roche, Pierre Couppié, Jean-François Guégan, Rodolphe Elie Gozlan
Many emerging infectious diseases are caused by generalist pathogens that infect and transmit via multiple host species with multiple dissemination routes, thus confounding the understanding of pathogen transmission pathways from wildlife reservoirs to humans. The emergence of these pathogens in human populations has frequently been associated with global changes, such as socio-economic, climate or biodiversity modifications, by allowing generalist pathogens to invade and persist in new ecological niches, infect new host species, and thus change the nature of transmission pathways...
April 26, 2017: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/28442754/vector-competence-and-transovarial-transmission-of-two-aedes-aegypti-strains-to-zika-virus
#8
Chun-Xiao Li, Xiao-Xia Guo, Yong-Qiang Deng, Dan Xing, Ai-Juan Sun, Qin-Mei Liu, Qun Wu, Yan-de Dong, Ying-Mei Zhang, Heng-Duan Zhang, Wu-Chun Cao, Cheng-Feng Qin, Tong-Yan Zhao
Zika virus (ZIKV) has become a serious threat to global health since the outbreak in Brazil in 2015. Additional Chinese cases have continuously been reported since the first case of laboratory-confirmed ZIKV infection in China on 6 February 2016. Aedes aegypti is the most important vector for ZIKV. This study shows that two strains from China exhibit high levels of midgut infection and highly disseminated infection of salivary glands and ovaries. Both strains can transmit ZIKV to infant mice bitten by infectious mosquitoes...
April 26, 2017: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/28442753/precision-immunomedicine
#9
Tianlei Ying, Yumei Wen, Dimiter S Dimitrov
No abstract text is available yet for this article.
April 26, 2017: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/28442752/zika-virus-infection-reprograms-global-transcription-of-host-cells-to-allow-sustained-infection
#10
Shashi Kant Tiwari, Jason Dang, Yue Qin, Gianluigi Lichinchi, Vikas Bansal, Tariq M Rana
Zika virus (ZIKV) is an emerging virus causally linked to neurological disorders, including congenital microcephaly and Guillain-Barré syndrome. There are currently no targeted therapies for ZIKV infection. To identify novel antiviral targets and to elucidate the mechanisms by which ZIKV exploits the host cell machinery to support sustained replication, we analyzed the transcriptomic landscape of human microglia, fibroblast, embryonic kidney and monocyte-derived macrophage cell lines before and after ZIKV infection...
April 26, 2017: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/28442751/varying-effects-of-common-tuberculosis-drugs-on-enhancing-clofazimine-activity-in-vitro
#11
Shuo Zhang, Wanliang Shi, Jie Feng, Wenhong Zhang, Ying Zhang
No abstract text is available yet for this article.
April 26, 2017: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/28442750/hepatitis-a-virus-infections-and-outbreaks-in-asylum-seekers-arriving-to-germany-september-2015-to-march-2016
#12
Kai Michaelis, Jürgen J Wenzel, Klaus Stark, Mirko Faber
From September 2015 to March 2016, hepatitis A notifications in Germany increased by 45% to 699 cases compared to 482 cases in the same period of the previous year. Children aged five to nine years were predominantly affected (22% of all cases in this period). We hypothesized that this increase could be explained by the marked influx of asylum seekers in this time period. We analysed national surveillance data and estimated the number of imported and autochthonous hepatitis A cases in asylum seekers. We also investigated molecular signatures of hepatitis A viruses sampled from asylum seekers to identify chains of transmission...
April 26, 2017: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/28442749/identification-of-drug-candidates-that-enhance-pyrazinamide-activity-from-a-clinical-compound-library
#13
Hongxia Niu, Chao Ma, Peng Cui, Wanliang Shi, Shuo Zhang, Jie Feng, David Sullivan, Bingdong Zhu, Wenhong Zhang, Ying Zhang
No abstract text is available yet for this article.
April 26, 2017: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/28400594/histo-blood-group-antigens-as-receptors-for-rotavirus-new-understanding-on-rotavirus-epidemiology-and-vaccine-strategy
#14
REVIEW
Xi Jiang, Yang Liu, Ming Tan
The success of the two rotavirus (RV) vaccines (Rotarix and RotaTeq) in many countries endorses a live attenuated vaccine approach against RVs. However, the lower efficacies of both vaccines in many low- and middle-income countries indicate a need to improve the current RV vaccines. The recent discovery that RVs recognize histo-blood group antigens (HBGAs) as potential receptors has significantly advanced our understanding of RV diversity, evolution and epidemiology, providing important new insights into the performances of current RV vaccines in different populations and emphasizing a P-type-based vaccine approach...
April 12, 2017: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/28400593/rickettsial-seropositivity-in-the-indigenous-community-and-animal-farm-workers-and-vector-surveillance-in-peninsular-malaysia
#15
Kai Ling Kho, Fui Xian Koh, Lailatul Insyirah Mohd Hasan, Li Ping Wong, Masoumeh Ghane Kisomi, Awang Bulgiba, Quaza Nizamuddin Hassan Nizam, Sun Tee Tay
Rickettsioses are emerging zoonotic diseases that are often neglected in many countries in Southeast Asia. Rickettsial agents are transmitted to humans through exposure to infected arthropods. Limited data are available on the exposure of indigenous community and animal farm workers to the aetiological agents and arthropod vectors of rickettsioses in Peninsular Malaysia. Serological analysis of Rickettsia conorii and Rickettsia felis was performed for 102 individuals from the indigenous community at six rural villages and 87 workers from eight animal farms in Peninsular Malaysia in a cross-sectional study...
April 12, 2017: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/28400592/recent-emergence-of-a-novel-porcine-pestivirus-interference-with-classical-swine-fever-diagnosis
#16
Alexander Postel, Denise Meyer, Anja Petrov, Paul Becher
No abstract text is available yet for this article.
April 12, 2017: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/28400591/pathogenicity-and-transmission-of-a-swine-influenza-a-h6n6-virus
#17
Hailiang Sun, Bryan S Kaplan, Minhui Guan, Guihong Zhang, Jianqiang Ye, Li-Ping Long, Sherry Blackmon, Chun-Kai Yang, Meng-Jung Chiang, Hang Xie, Nan Zhao, Jim Cooley, David F Smith, Ming Liao, Carol Cardona, Lei Li, George Peng Wang, Richard Webby, Xiu-Feng Wan
Subtype H6 influenza A viruses (IAVs) are commonly detected in wild birds and domestic poultry and can infect humans. In 2010, a H6N6 virus emerged in southern China, and since then, it has caused sporadic infections among swine. We show that this virus binds to α2,6-linked and α2,3-linked sialic acids. Mutations at residues 222 (alanine to valine) and 228 (glycine to serine) of the virus hemagglutinin (HA) affected its receptor-binding properties. Experiments showed that the virus has limited transmissibility between ferrets through direct contact or through inhalation of infectious aerosolized droplets...
April 12, 2017: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/28400590/diversity-and-role-of-cave-dwelling-hematophagous-insects-in-pathogen-transmission-in-the-afrotropical-region
#18
REVIEW
Judicaël Obame-Nkoghe, Eric-Maurice Leroy, Christophe Paupy
The progressive anthropization of caves for food resources or economic purposes increases human exposure to pathogens that naturally infect cave-dwelling animals. The presence of wild or domestic animals in the immediate surroundings of caves also may contribute to increasing the risk of emergence of such pathogens. Some zoonotic pathogens are transmitted through direct contact, but many others require arthropod vectors, such as blood-feeding insects. In Africa, hematophagous insects often play a key role in the epidemiology of many pathogens; however, their ecology in cave habitats remains poorly known...
April 12, 2017: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/28352124/discovery-and-genetic-analysis-of-novel-coronaviruses-in-least-horseshoe-bats-in-southwestern-china
#19
Lihua Wang, Shihong Fu, Yuxi Cao, Hailin Zhang, Yun Feng, Weihong Yang, Kai Nie, Xuejun Ma, Guodong Liang
To investigate bat coronaviruses (CoVs), we collected 132 rectal swabs and urine samples from five bat species in three countries in southwestern China. Seven CoVs belonging to distinct groups of severe acute respiratory syndrome (SARS)-like CoVs and α-CoVs were detected in samples from least horseshoe bats. Samples from other bat species were negative for these viruses, indicating that the least horseshoe bat represents one of the natural reservoirs and mixers for strains of CoVs and has a pivotal role in the evolution and dissemination of these viruses...
March 29, 2017: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/28352123/axl-is-not-essential-for-zika-virus-infection-in-the-mouse-brain
#20
Feng Li, Pei-Rong Wang, Lin-Bing Qu, Chang-Hua Yi, Fu-Chun Zhang, Xiao-Ping Tang, Li-Guo Zhang, Ling Chen
No abstract text is available yet for this article.
March 29, 2017: Emerging Microbes & Infections
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