Read by QxMD icon Read

Emerging Microbes & Infections

Liqun Zhang, Yu Pang, Xia Yu, Yufeng Wang, Jie Lu, Mengqiu Gao, Hairong Huang, Yanlin Zhao
Pulmonary cavitation is one of the most frequently observed clinical characteristics in tuberculosis (TB). The objective of this study was to investigate the potential risk factors associated with cavitary TB in China. A total of 385 smear-positive patients were enrolled in the study, including 192 (49.9%) patients with cavitation as determined by radiographic findings. Statistical analysis revealed that the distribution of patients with diabetes in the cavitary group was significantly higher than that in the non-cavitary group (adjusted odds ratio (OR) (95% confidence interval (CI)):12...
October 12, 2016: Emerging Microbes & Infections
Azeem Mehmood Butt, Izza Nasrullah, Raheel Qamar, Yigang Tong
The codon usage patterns of viruses reflect the evolutionary changes that allow them to optimize their survival and adapt their fitness to the external environment and, most importantly, their hosts. Here we report the genotype-specific codon usage patterns of Zika virus (ZIKV) strains from the current and previous outbreaks. Several genotype-specific and common codon usage traits were noted in the ZIKV coding sequences, indicating their independent evolutionary origins from a common ancestor. The overall influence of natural selection was more profound than that of mutation pressure, acting on a specific set of viral genes in the Asian-genotype ZIKV strains from the recent outbreak...
October 12, 2016: Emerging Microbes & Infections
Jilei Zhang, Patrick John Kelly, Guangwu Lu, Luis Cruz-Martinez, Chengming Wang
No abstract text is available yet for this article.
October 12, 2016: Emerging Microbes & Infections
Yishi Xu, Carla Bianca Luena Victorio, Qimei Ng, Mookkan Prabakaran, Yee-Joo Tan, Kaw Bing Chua
The Saffold virus (SAFV) genome is translated as a single long polyprotein precursor and co-translationally cleaved to yield 12 separate viral proteins. Little is known about the activities of SAFV proteins although their homologs in other picornaviruses have already been described. To further support research on functions and activities of respective viral proteins, we investigated the spatio-temporal distribution of SAFV proteins in Vero and HEp-2 cells that had been either transfected with plasmids that express individual viral proteins or infected with live SAFV...
October 12, 2016: Emerging Microbes & Infections
Jasper Fuk-Woo Chan, Cyril Chik-Yan Yip, Jessica Oi-Ling Tsang, Kah-Meng Tee, Jian-Piao Cai, Kenn Ka-Heng Chik, Zheng Zhu, Chris Chung-Sing Chan, Garnet Kwan-Yue Choi, Siddharth Sridhar, Anna Jinxia Zhang, Gang Lu, Kin Chiu, Amy Cheuk-Yin Lo, Sai-Wah Tsao, Kin-Hang Kok, Dong-Yan Jin, Kwok-Hung Chan, Kwok-Yung Yuen
Zika virus (ZIKV) is unique among human-pathogenic flaviviruses by its association with congenital anomalies and trans-placental and sexual human-to-human transmission. Although the pathogenesis of ZIKV-associated neurological complications has been reported in recent studies, key questions on the pathogenesis of the other clinical manifestations, non-vector-borne transmission and potential animal reservoirs of ZIKV remain unanswered. We systematically characterized the differential cell line susceptibility of 18 human and 15 nonhuman cell lines to two ZIKV isolates (human and primate) and dengue virus type 2 (DENV-2)...
August 24, 2016: Emerging Microbes & Infections
Jennifer Lambour, Mar Naranjo-Gomez, Marc Piechaczyk, Mireia Pelegrin
Monoclonal antibodies (mAbs), which currently constitute the main class of biotherapeutics, are now recognized as major medical tools that are increasingly being considered to fight severe viral infections. Indeed, the number of antiviral mAbs developed in recent years has grown exponentially. Although their direct effects on viral blunting have been studied in detail, their potential immunomodulatory actions have been overlooked until recently. The ability of antiviral mAbs to modulate antiviral immune responses in infected organisms has recently been revealed...
August 17, 2016: Emerging Microbes & Infections
Thomas Arn Hansen, Sarah Mollerup, Nam-Phuong Nguyen, Nicole E White, Megan Coghlan, David E Alquezar-Planas, Tejal Joshi, Randi Holm Jensen, Helena Fridholm, Kristín Rós Kjartansdóttir, Tobias Mourier, Tandy Warnow, Graham J Belsham, Michael Bunce, Eske Willerslev, Lars Peter Nielsen, Lasse Vinner, Anders Johannes Hansen
Outbreaks of zoonotic diseases in humans and livestock are not uncommon, and an important component in containment of such emerging viral diseases is rapid and reliable diagnostics. Such methods are often PCR-based and hence require the availability of sequence data from the pathogen. Rattus norvegicus (R. norvegicus) is a known reservoir for important zoonotic pathogens. Transmission may be direct via contact with the animal, for example, through exposure to its faecal matter, or indirectly mediated by arthropod vectors...
August 17, 2016: Emerging Microbes & Infections
Zebin Liao, Yu Yan, Huaihuai Dong, Zhenyu Zhu, Yuanying Jiang, Yingying Cao
The aim of the present study was to investigate the role of nitric oxide (NO) in the antifungal activity of Shikonin (SK) against Candida albicans (C. albicans) and to clarify the underlying mechanism. The results showed that the NO donors S-nitrosoglutathione (GSNO) and L-arginine could enhance the antifungal activity of SK, whereas the NO production inhibitor Nω-nitro-L-arginine methyl ester (L-NAME) attenuated antifungal action. Using the fluorescent dye 3-amino,4-aminomethyl-2', 7-difluorescein, diacetate (DAF-FM DA), we found that the accumulation of NO in C...
August 17, 2016: Emerging Microbes & Infections
Jeanette Wp Teo, Ka Lip Chew, Raymond Tp Lin
No abstract text is available yet for this article.
August 17, 2016: Emerging Microbes & Infections
Gang Luo, Lixing Huang, Yongquan Su, Yingxue Qin, Xiaojin Xu, Lingmin Zhao, Qingpi Yan
Adhesion is an important virulence trait of Vibrio alginolyticus. Bacterial adhesion is influenced by environmental conditions; however, the molecular mechanism underlying this effect remains unknown. The expression levels of flrA, flrB and flrC were significantly downregulated in adhesion-deficient V. alginolyticus strains cultured under Cu(2+), Pb(2+), Hg(2+) and low-pH stresses. Silencing these genes led to deficiencies in adhesion, motility, flagellar assembly, biofilm formation and exopolysaccharide (EPS) production...
August 3, 2016: Emerging Microbes & Infections
Yuanyuan Liu, Qinfang Ou, Jian Zheng, Lei Shen, Bingyan Zhang, Xinhua Weng, Lingyun Shao, Yan Gao, Wenhong Zhang
The differential diagnosis of tuberculous pleural effusion (TPE) and malignant pleural effusion (MPE) remains difficult despite the availability of numerous diagnostic tools. The current study aimed to evaluate the performance of the whole blood QuantiFERON-TB Gold In-Tube (QFT-GIT) assay and conventional laboratory biomarkers in differential diagnosis of TPE and MPE in high tuberculosis prevalence areas. A total of 117 patients with pleural effusions were recruited, including 91 with TPE and 26 with MPE. All of the patients were tested with QFT-GIT, and the conventional biomarkers in both blood and pleural effusion were detected...
August 3, 2016: Emerging Microbes & Infections
Wendy Blay Puryear, Mandy Keogh, Nichola Hill, Jerry Moxley, Elizabeth Josephson, Kimberly Ryan Davis, Chistopher Bandoro, Damian Lidgard, Andrea Bogomolni, Milton Levin, Shelley Lang, Michael Hammill, Don Bowen, David W Johnston, Tracy Romano, Gordon Waring, Jonathan Runstadler
Influenza A virus (IAV) has been associated with multiple unusual mortality events (UMEs) in North Atlantic pinnipeds, frequently attributed to spillover of virus from wild-bird reservoirs. To determine if endemic infection persists outside of UMEs, we undertook a multiyear investigation of IAV in healthy, live-captured Northwest Atlantic gray seals (Halichoerus grypus). From 2013 to 2015, we sampled 345 pups and 57 adults from Cape Cod, MA, USA and Nova Scotia, Canada consistently detecting IAV infection across all groups...
August 3, 2016: Emerging Microbes & Infections
Shisong Fang, Tian Bai, Lei Yang, Xin Wang, Bo Peng, Hui Liu, Yijie Geng, Renli Zhang, Hanwu Ma, Wenfei Zhu, Dayan Wang, Jinquan Cheng, Yuelong Shu
Sporadic human infections with the highly pathogenic avian influenza (HPAI) A (H5N6) virus have been reported in different provinces in China since April 2014. From June 2015 to January 2016, routine live poultry market (LPM) surveillance was conducted in Shenzhen, Guangdong Province. H5N6 viruses were not detected until November 2015. The H5N6 virus-positive rate increased markedly beginning in December 2015, and viruses were detected in LPMs in all districts of the city. Coincidently, two human cases with histories of poultry exposure developed symptoms and were diagnosed as H5N6-positive in Shenzhen during late December 2015 and early January 2016...
August 3, 2016: Emerging Microbes & Infections
Giovanni Di Guardo, Patrícia Baleeiro Beltrão Braga, Jean Pierre Schatzmann Peron
No abstract text is available yet for this article.
2016: Emerging Microbes & Infections
Veasna Duong, Channa Mey, Marc Eloit, Huachen Zhu, Lucie Danet, Zhong Huang, Gang Zou, Arnaud Tarantola, Justine Cheval, Philippe Perot, Denis Laurent, Beat Richner, Santy Ky, Sothy Heng, Sok Touch, Ly Sovann, Rogier van Doorn, Thanh Tan Tran, Jeremy J Farrar, David E Wentworth, Suman R Das, Timothy B Stockwell, Jean-Claude Manuguerra, Francis Delpeyroux, Yi Guan, Ralf Altmeyer, Philippe Buchy
Human enterovirus 71 (EV-A71) causes hand, foot and mouth disease (HFMD). EV-A71 circulates in many countries and has caused large epidemics, especially in the Asia-Pacific region, since 1997. In April 2012, an undiagnosed fatal disease with neurological involvement and respiratory distress occurred in young children admitted to the Kantha Bopha Children's Hospital in Phnom Penh, Cambodia. Most died within a day of hospital admission, causing public panic and international concern. In this study, we describe the enterovirus (EV) genotypes that were isolated during the outbreak in 2012 and the following year...
2016: Emerging Microbes & Infections
Samuel Cordey, Francisco Brito, Diem-Lan Vu, Lara Turin, Mary Kilowoko, Esther Kyungu, Blaise Genton, Evgeny M Zdobnov, Valérie D'Acremont, Laurent Kaiser
No abstract text is available yet for this article.
2016: Emerging Microbes & Infections
Min Chen, Abdullah Ms Al-Hatmi, Yuchong Chen, Yang Ying, Wenjie Fang, Jianping Xu, Ferry Hagen, Nan Hong, Teun Boekhout, Wanqing Liao, Weihua Pan
No abstract text is available yet for this article.
2016: Emerging Microbes & Infections
Hon S Ip, Jeffrey M Lorch, David S Blehert
Global translocation of plants and animals is a well-recognized mechanism for introduction of pathogens into new regions. To mitigate this risk, various tools such as preshipment health certificates, quarantines, screening for specific disease agents and outright bans have been implemented. However, such measures only target known infectious agents and their hosts and may fail to prevent translocation of even well-recognized pathogens if they are carried by novel host species. In a recent example, we screened an imported shipment of Chinese firebelly newts (Cynops orientalis) for Batrachochytrium salamandrivorans, an emergent fungal pathogen of salamanders...
2016: Emerging Microbes & Infections
Wenjie Fang, Min Chen, Jia Liu, Ferry Hagen, Abdullah Ms, Al-Hatmi, Peilian Zhang, Yun Guo, Teun Boekhout, Danqi Deng, Jianping Xu, Weihua Pan, Wanqing Liao
Cryptococcal meningitis is an important fungal infection among systemic lupus erythematosus patients. We conducted a pooled analysis and systematic review to describe the epidemiological and clinical profile of cryptococcal meningitis in systemic lupus erythematosus patients. From two hospitals in China and nine literature databases, cases and prevalence data were collected for pooled analysis and meta-analysis, respectively. Categorical variables of cases were compared using a χ(2)-test on the statistical program of SAS...
2016: Emerging Microbes & Infections
Xiao-Xia Guo, Chun-Xiao Li, Yong-Qiang Deng, Dan Xing, Qin-Mei Liu, Qun Wu, Ai-Juan Sun, Yan-de Dong, Wu-Chun Cao, Cheng-Feng Qin, Tong-Yan Zhao
Zika virus (ZIKV) has become a threat to global health since the outbreak in Brazil in 2015. Although ZIKV is generally considered an Aedes-transmitted pathogen, new evidence has shown that parts of the virus closely resemble Culex-transmitted viruses. Therefore, it is important to evaluate the competence of Culex species for ZIKV to understand their potential as vectors. In this study, female Culex pipiens quinquefasciatus were orally exposed to ZIKV. Mosquito midguts, salivary glands and ovaries were tested for ZIKV to measure infection and dissemination at 2, 4, 6, 8, 12, 16 and 18 days post exposure (pe)...
2016: Emerging Microbes & Infections
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"