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Journal of Pharmacopuncture

Kangwook Lee, Yoon-Sik Kim, Chang-Gue Son, Jung-Hyo Cho, Hwa-Seung Yoo, Jonghoon Lee, Juyoung Ryu, Namhun Lee
ABSTRACT: HASH(0x389cfd8) ABSTRACT: Lung cancer has a high mortality rate and is often diagnosed at the metastatic stage. Gefitinib is a targeted molecular therapeutic drug used to treat patients with non-small-cell lung cancer (NSCLC). Korean herbal medicines may also have therapeutic efficacy against lung cancer, reduce the side effects associated with chemotherapy, and improve patient quality of life (QOL). This case report describes the effects of a Korean herbal medicine regimen combined with gefitinib in a patient with NSCLC and bone metastasis...
September 2016: Journal of Pharmacopuncture
Gotmi Sharwan, Parag Jain, Ravindra Pandey, Shiv Shankar Shukla
OBJECTIVES: The goals of this research were to evaluate acute (single-dose) and sub-acute (repeated-dose) toxicity profiles of methanolic extract of Pistacia integerrima J. L. Stewart ex Brandis (PI) for Wistar rats and to assess the safety profile of PI by observing physiological changes, mortality, changes in body weight, the histopathology of body organs, the hematology and the biochemistry of the animals. METHODS: The toxicity profile of PI was evaluated using Wistar rats of both sexes...
September 2016: Journal of Pharmacopuncture
Mehrab Dashtdar, Mohammad Reza Dashtdar, Babak Dashtdar, Gazala Afreen Khan, Karima Kardi
OBJECTIVES: The purpose of this study was to obtain a natural antibiotic from Phenol-rich compounds; for the dressing and the treatment of chronic wounds. METHODS: The Phenol-rich compound sweet gel was prepared by blending four natural herbal extracts, Acacia catechu (L.F.), Momia (Shilajit), Castanea sativa, and Ephedra sinica stapf, with combination of a sweet gel medium, including honey, maple saps, Phoenix dactylifera L. (date), pomegranate extract and Azadirachta indica gum as a stabilizer...
September 2016: Journal of Pharmacopuncture
Eiji Inoue, Yasuharu Shimizu, Ryo Masui, Tomoe Tsubonoya, Tomomi Hayakawa, Keiichi Sudoh
OBJECTIVES: This study was conducted to clarify the effects of agarwood on histamine release from mast cells in rats and on the scratching behaviors in mice. METHODS: Histamine release from rat mast cells induced by compound 48/80 or concanavalin A (Con A) and compound 48/80-induced scratching behavior in mice were examined to investigate the effects of agarwood. The hyaluronidase activity and the 3',5'-cyclic adenosine monophosphate (cAMP) levels in mast cells were examined to investigate the mechanisms for the inhibition of histamine release...
September 2016: Journal of Pharmacopuncture
Hwa-Young Lee, Sungchul Kim, Seung-Hun Cho
OBJECTIVES: This study used repeated intravenous injections of Saeng Maek San (SMS) injection in Sprague-Dawley (SD) rats to assess the toxicity and the stability of SMS. METHODS: Six-week-old male and female SD rats reared by Orient bio Inc were chosen for this pilot study. They were randomly split into four groups: Group 1 (G1), the control group (0.3 mL of normal saline solution/day/animal), and Groups 2, 3 and 4 (G2, G3 and G4), the experimental groups (0.1, 0...
September 2016: Journal of Pharmacopuncture
Hossein Zolfagharian, Mohammad Mohajeri, Mahdi Babaie
OBJECTIVES: Mellitine, a major component of bee venom (BV, Apis mellifera), is more active against gram positive than gram negative bacteria. Moreover, BV has been reported to have multiple effects, including antibacterial, antivirus, and anti-inflammation effects, in various types of cells. In addition, wasp venom has been reported to have antibacterial properties. The aim of this study was to evaluate the antibacterial activity of BV against selected gram positive and gram negative bacterial strains of medical importance...
September 2016: Journal of Pharmacopuncture
Mi-Kyung Jeong, Chong-Kwan Cho, Hwa-Seung Yoo
OBJECTIVES: Ginseng Rh2+ is enzyme-treated ginseng extract containing high amounts of converted ginsenosides, such as compound k, Rh2, Rg3, which have potent anticancer activity. We conducted general and genetic toxicity tests to evaluate the safety of ginseng Rh2+. METHODS: An acute oral toxicity test was performed at a high-level dose of 4,000 mg/kg/day in Sprague-Dawley (SD) rats. A 14-day range-finding study was also conducted to set dose levels for the 90-day study...
September 2016: Journal of Pharmacopuncture
Vernon Bond, Bryan H Curry, Krishna Kumar, Sudhakar Pemminati, Vasavi R Gorantla, Kishan Kadur, Richard M Millis
OBJECTIVES: Acupuncture treatments are safe and effective for a wide variety of diseases involving autonomic dysregulation. Heart rate variability (HRV) is a noninvasive method for assessing sympathovagal balance. The low frequency/high frequency (LF/HF) spectral power ratio is an index of sympathovagal influence on heart rate and of cardiovascular health. This study tests the hypothesis that from rest to 30% to 50% of peak oxygen consumption, the nonlinear Conte-Zbilut-Federici (CZF) method of computing the LF/HF ratio is a more reliable index of changes in the HRV than linear methods are...
September 2016: Journal of Pharmacopuncture
Jae-Young Shin, Jun-Hwan Lee, Boncho Ku, Jang Han Bae, Min-Ho Un, Jaeuk U Kim, Tae-Hun Kim
INTRODUCTION: This study aims to investigate the effects of acupuncture stimulation on the radial artery's pressure pulse wave, along with various hemodynamic parameters, and to explore the possible underlying mechanism of pulse diagnosis in healthy participants in their twenties. METHODS AND ANALYSIS: This study is a prospective, single-arm, exploratory clinical study. A total of 25 healthy participants, without regard to gender, in their twenties will be recruited by physicians...
September 2016: Journal of Pharmacopuncture
Yulia A Volkova, Isaac Opoku-Asare, Luc M Oke, Sudhakar Pemminati, Richard M Millis
No abstract text is available yet for this article.
September 2016: Journal of Pharmacopuncture
Sahar Moghbelinejad, Zahra Rashvand, Fatemeh Khodabandehloo, Ghazaleh Mohammadi, Marjan Nassiri-Asl
OBJECTIVES: Quercetin is a flavonoid and an important dietary constituent of fruits and vegetables. In recent years, several pharmacological activities of quercetin, such as its neuroprotective activity and, more specifically, its anti-convulsant effects in animal models of epilepsy, have been reported. This study evaluated the role of quercetin pretreatment on gene expression of γ-amino butyric acid type A (GABAA) receptor beta subunits in kainic acid (KA)-induced seizures in mice. METHODS: The animals were divided into four groups: one saline group, one group in which seizures were induced by using KA (10 mg/kg) without quercetin pretreatment and two groups pretreated with quercetin (50 and 100 mg/kg) prior to seizures being induced by using KA...
June 2016: Journal of Pharmacopuncture
Ki-Rok Kwon, Jun-Sang Yu, Seung-Ho Sun, Kwang-Ho Lee
OBJECTIVES: Bufonis venonum (BV) is toad venom and is the dried, white secretions of the auricular and the skin glands of toads. This study was performed to evaluate the toxicity of intravenous injection of Bufonis venonum pharmacopuncture (BVP) through a single- dose test with sprague-dawley (SD) rats. METHODS: Twenty male and 20 female 6-week-old SD rats were injected intravenously in the caudal vein with BVP or normal saline. The animals were divided into four groups with five female and five male rats per group: the control group injected with normal saline, the low-dosage group injected with 0...
June 2016: Journal of Pharmacopuncture
Yung Sing Ch'ng, Chu Shan Tan, Yean Chun Loh, Mariam Ahmad, Mohd Zaini Asmawi, Mun Fei Yam
OBJECTIVES: The aim of this paper is to investigate the activities of Malaysian local herbs (Clinacanthus nutans Lindau, Strobilanthes crispus, Murdannia bracteata, Elephantopus scaber Linn., Pereskia bleo, Pereskia grandifolia Haw., Vernonia amygdalina, and Swietenia macrophylla King) for anti-hypertensive and vasorelaxant activity. An infrared (IR) macro-fingerprinting technique consisting of conventional fourier transform IR (FTIR), second-derivative IR (SD-IR), and two-dimensional correlation IR (2D-correlation IR) analyses were used to determine the main constituents and the fingerprints of the Malaysian local herbs...
June 2016: Journal of Pharmacopuncture
Amrita Singh, Samsroz Ahmad Khan, Rajesh Choudhary, Surendra Haribhau Bodakhe
OBJECTIVES: Several studies have revealed that systemic hypertension is strongly associated with cataractogenesis. However, the pathophysiology and treatment is often unclear. In this study, we evaluated the anti-cataractogenic effect of cinnamaldehyde (CA), a natural organic compound, in rats with fructose-induced hypertension. METHODS: The rats were divided into six groups. For six weeks, the normal group received a suspension of 0.5% carboxy methyl cellulose (10 mL/kg/day, p...
June 2016: Journal of Pharmacopuncture
Ji Hwan Shim, Huijin Gim, Soojin Lee, Byung Joo Kim
OBJECTIVES: The crude extracts of Scutellaria barbata D. Don (SB) have traditionally demonstrated inhibitory effects on numerous human cancers both in vitro and in vivo. Gastric cancer is one of the most common types of cancer on world. The authors investigated the effects of an ethanol extract of Scutellaria barbata D. Don (ESB) on the growth and survival of MKN-45 cells (a human gastric adenocarcinoma cell line). METHODS: The MKN-45 cells were treated with different concentrations of ESB, and cell death was examined using an MTT (3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide) assay...
June 2016: Journal of Pharmacopuncture
Seon-Yong Lee, Dong-Jin Lee, Kang Kwon, Chang-Hyun Lee, Hyun Jong Shin, Jai Eun Kim, Ki-Tae Ha, Han-Sol Jeong, Hyung-Sik Seo
OBJECTIVES: Cornu cervi pantotrichum (CCP) has been widely used in Korean and China, as an anti-fatigue, anti-aging, and tonic agent to enhance the functions of the reproductive and the immune systems. Because CCP has various growth factors that play important roles in the development of hair follicles, we examined whether CCP pharmacopuncture solution (CCPPS) was capable of promoting hair growth in an animal model. METHODS: One day after hair depilation, CCPPS were topically applied to the dorsal skin of C57BL/6 mice once a day for 15 days...
June 2016: Journal of Pharmacopuncture
Yogesh Bendale, Vineeta Bendale, Rammesh Natu, Saili Paul
OBJECTIVES: Lung cancer remains a deadly disease with unsatisfactory overall survival. Cisplatin, a standard platinum (Pt)-based chemotherapeutic agent, has the potential to inhibit the growth of lung cancer. Its use, however, is occasionally limited by severe organ toxicity. However, until now, no systematic study has been conducted to verify its efficacy with proper experimental support in vivo. Therefore, we examined whether biosynthesized Pt nanoparticles (NPs) inhibited human lung cancer in vitro and in vivo to validate their use in alternative and complementary medicine...
June 2016: Journal of Pharmacopuncture
Daniela Litscher, Gerhard Litscher
This short review article presents a current overview of existing publications and scientific results regarding liquid (ear) acupuncture. The injection of liquids into defined acupuncture points of the ear is not a method commonly used in the Western world. The term liquid acupuncture has different definitions, which makes understanding each definition and differentiating one from the other difficult. General terms like pharmacopuncture, homeosiniatry, and liquid acupuncture, which all describe the method of injecting different kinds of drugs into a defined body acupuncture point, are used...
June 2016: Journal of Pharmacopuncture
Kwang-Ho Lee, Yoon-Young Cho, Sungchul Kim, Seung-Ho Sun
OBJECTIVES: This study introduces the history and types of Korean pharmacopuncture and reports trends of research on Korean pharmacopuncture. METHODS: Pharmacopuncture studies were searched from the first year of each search engine to 2014 by using seven domestic and foreign search databases. Selected studies were divided into the history of pharmacopuncture, kinds and features of pharmacopuncture, research types, and experimental and clinic studies and were then classified by year of publication, type of pharmacopuncture, disease, and topic...
June 2016: Journal of Pharmacopuncture
Shagayegh Nozari, Mohtaram Adine, Farzaneh Javadi, Mojtaba Shahnazi, Abbas Azadmehr, Marjan Nassiri-Asl, Hasan Jahanihashemi, Mehrzad Saraei
OBJECTIVES: This study was performed to determine the lethal and the inhibitory effects of ethanol extracts of Achillea millefolium (A. millefolium) and Hypericum perforatum (H. perforatum) on Toxoplasma gondii (T. gondii) RH strain tachyzoites in vitro. METHODS: The tachyzoites were treated with concentrations of 10, 50, and 100 mg/mL of A. millefolium and H. perforatum extracts within 10, 30, and 45 minutes in the wells. The mortality rates of tachyzoites treated with extracts were determined by using alkaline methylene blue staining...
March 2016: Journal of Pharmacopuncture
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