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Cardiology Research

Ankur A Karnik, Eric H Awtry
Systemic rheumatologic and inflammatory disorders can affect almost any organ system, including the heart. The cardiac valves, conduction system, myocardium, endocardium, pericardium, and coronary arteries may be affected. Intracardiac masses may develop as part of the disease process or a consequence of their therapy, such as methotrexate-associated nodulosis. Optimal therapy in these cases is not known, since many patients are asymptomatic and the potential benefit of surgical excision must be weighed against its associated morbidity and mortality...
December 2018: Cardiology Research
Michal Kuzemczak, Ryszard Kasinowski, Piotr Skrobich, Roland Podlewski, Piotr Kalmucki
ST-segment elevation myocardial infarction (STEMI) due to simultaneous double vessel thrombotic occlusion of two major coronary arteries is an extremely rare clinical entity. Available studies indicate that most frequently it affects two coronary arteries originating from different sides of a coronary tree (i.e. right coronary artery (RCA) and left anterior descending artery (LAD) or RCA and left circumflex artery (LCx)) and usually has a fatal clinical course. However, it must be pointed out that the data have been derived from studies before the era of a widely-used pre-hospital electrocardiogram (ECG) teletransmission...
December 2018: Cardiology Research
Andrea D'Alessio, Danilo Verdichizzo, Fabio Falconieri, Amar Keiralla, Joanna Abramik, Georgios Kasimis, George Krasopoulos
Thrombocytopenia is a recognized complication following aortic valve replacement (AVR). While post-operative thrombotic thrombocytopenic purpura (TTP) is less common than heparin-induced thrombocytopenia (HIT), it is associated with high mortality and morbidity and prompt diagnosis and treatment is vital. In this case report, we describe the first reported case of TTP after AVR using the trifecta bio-prosthesis. We recommend that patients with severe and progressive thrombocytopenia following biological AVR should have early screening for both HIT and TTP, to shorten the decision-making process and provide the appropriate therapy...
December 2018: Cardiology Research
Quang Tan Phan, Hieu Lan Nguyen, Tai Duc Le, WangSoo Lee, HoYoun Won, SeungYong Shin, Saima Sharmin, Truong Quang Nguyen, SangWook Kim
Even cardiac surgery has been accepted as the standard therapy for Lutembacher syndrome, a combination of congenital ostium secundum atrial septal defect (ASD) and acquired mitral valve stenosis (MVS), it also owns many limitations and disadvantages. Therefore, seeking for a less invasive therapy with the same efficacy may be worthwhile. Thanks to the development in technology and experience gaining in cardiovascular intervention, the combination of the two proved effective procedures, including percutaneous MVS treatment using balloon valvuloplasty and percutaneous ASD closure using atrial septal occluders, can be utilized as an attractive alternative therapy for these conditions...
December 2018: Cardiology Research
Clemence Bretaudeau, Charlotte Vaysse, Paul Guerby, Olivier Lairez, Marc Soule-Tholy, Fabien Vidal, Elodie Chantalat
A ruptured breast implant is usually asymptomatic and accidentally discovered during an imaging test. However, implant ruptures can cause isolated silicone granulomas and cases of severe systemic disease. We report the first case of a 39-year-old female patient with augmentation breast implants and myopericarditis secondary to implant rupture. Many etiologies of myopericarditis were explored, but none were selected with the exception of the rupture of the implant in the left breast. Magnetic resonance imaging showed a prosthetic rupture with capsular intrusion and formation of a silicone granuloma with inflammation of the pericardium on contact...
December 2018: Cardiology Research
Mohinder Reddy Vindhyal, Venkata S Boppana, Shravani Vindhyal
Takotsubo cardiomyopathy is a form of reversible cardiomyopathy. It is usually due to sudden emotional or physical stress. It is associated with excessive sympathetic stimulation and catecholamine release. Patients have a very similar presentation to an acute coronary syndrome with patent coronaries. We present a case of takotsubo cardiomyopathy in a patient who has a history of Sjogren's disease on a steroid taper.
December 2018: Cardiology Research
Suresh V Patted, Anmol Suresh Patted, Prakash Kumar Turiya, Ashok S Thakkar
Background: The thinnest strut platform is revolutionary improvement into the field of percutaneous coronary intervention. The aim of this study was to assess the safety and performance of world's thinnest (50 µm) strut biodegradable polymer coated Evermine 50™ everolimus-eluting coronary stent system (EES) in real-world patients with coronary artery disease. Methods: This was a prospective, single-arm, single-center, post-marketing study in real-world patients...
December 2018: Cardiology Research
Praveen Chandra, Ajaykumar U Mahajan, Vipin D Bulani, Ashok S Thakkar
Background: MeRes100™ (Meril Life Sciences Pvt. Ltd., Vapi, India) is a novel sirolimus-eluting bioresorbable vascular scaffold (BRS). The purpose of this sub-study of MeRes-1 trial is to evaluate the systemic release of sirolimus from MeRes100 BRS implanted for the treatment of de novo native coronary artery lesions. Methods: The MeRes-1 is a prospective, multicenter, first-in-human trial of sirolimus-eluting MeRes100 BRS. The pharmacokinetic sub-study was conducted at two Indian sites in 10 patients who were implanted with the MeRes100 BRS loaded with sirolimus at a dose of 1...
December 2018: Cardiology Research
Emily Mae L Yap, Myla Gloria S Supe, Ira I Yu
Background: Cardiac complications among patients with liver cirrhosis have not yet been described among Filipinos. Cirrhotic cardiomyopathy is a rarely described complication that has not been extensively described in literature. This is the first study to describe the electrocardiographic and echocardiographic findings of Filipino patients with liver cirrhosis. Methods: A retrospective analytical study of 148 patients with liver cirrhosis from 2007 to 2016 at the Philippine Heart Center was done...
December 2018: Cardiology Research
Suresh V Patted, Rajendra Kumar Jain, P A Jiwani, Satish Suryavanshi, T R Raghu, Hema Raveesh, S Rajalakshmi, Ashok S Thakkar, Prakash Kumar Turiya, Priyanka J Desai, Anmol Suresh Patted, Kamal H Sharma
Background: When coronary lesions involve segments > 48 mm, the only treatment possibility is stent overlapping which is associated with higher neointimal proliferation that lead to more restenosis. Furthermore, tapering of coronary arteries is a major challenge observed with long diffuse coronary lesions. This study attempted to assess the safety and performance of world's first commercialised long-tapered (60 mm) sirolimus-eluting coronary stent (SES) system for the treatment of long diffused de novo coronary lesions in real world scenario...
December 2018: Cardiology Research
Eli F Kelley, Eric M Snyder, Bruce D Johnson
Background: The beta-1 adrenergic receptor (ADRB1) has been shown to play a functional role in cardiomyocyte function and accounts for up to 80% of the cardiac tissue adrenergic receptors with ADRB1 stimulation increasing cardiac rate, contractility and work. Multiple polymorphisms of the ADRB1 have been identified such as the Gly49 polymorphism that includes at least one glycine (Gly) for serine (Ser) at amino acid 49 resulting in either homozygous for Gly (Gly49Gly) or heterozygous for Gly (Gly49Ser) polymorphisms...
December 2018: Cardiology Research
Sarina Sachdev, Nikky Bardia, Landai Nguyen, Bassam Omar
Degenerative valve disease is on the rise with greater than 100,000 valve operations performed in the US alone per year. The majority of those procedures employ tissue bioprostheses to avoid the attendant risk of anticoagulation, especially in the elderly. Though traditionally this approach has been considered a superior option to avoid anticoagulation, more recent analyses have demonstrated a significant incidence of previously unrecognized thrombosis associated with bioprosthetic valves, especially with the more recent advent of the transcatheter aortic valve replacement implantations...
December 2018: Cardiology Research
Rachel Stork Poeppelman, Joseph D Tobias
In utero , the ductus venosus connects the left portal vein to the inferior vena cava, allowing a portion of the venous blood to bypass the liver and return to the heart. After birth, the ductus venosus closes due to changes in intracardiac pressures and a decrease in endogenous prostaglandins. Failure of the ductus venosus to close may result in galactosemia, hypoxemia, encephalopathy with hyperammonia, and hepatic dysfunction. We report an infant with complex congenital heart disease (CHD) who developed coagulopathy and hyperammonia during the preoperative period secondary to patent ductus venosus (PDV)...
October 2018: Cardiology Research
Marilena Renata Spiridon, Antoniu Octavian Petris, Eusebiu Vlad Gorduza, Anca Sabina Petras, Roxana Popescu, Lavinia Caba
Holt-Oram syndrome (HOS) is a rare monogenic disorder characterized by upper limb abnormalities, congenital heart defects and/or conduction abnormalities. It is determined by mutations of TBX5 gene and is inherited in an autosomal dominant manner. Penetrance is complete, but variable expressivity is present, which gives sometimes diagnostic difficulties. Our case is a young adult with a personal history of preaxial polydactyly operated in infancy, multiple cardiac malformations (atrial septal defect, bicuspid aortic valve, left ventricular non-compaction) and radiologic findings consistent with HOS...
October 2018: Cardiology Research
Gurkirat Singh, Hemant Khemani, Rahul Singla, Shakil Shaikh, Vishal Patil, Narender Omprakash Bansal
Coronary artery aneurysm is defined as the localized dilatation of a coronary artery segment more than 1.5 times the size of adjacent normal segments. The aneurysms of the coronary arteries are rare. Coronary aneurysms can be congenital or acquired. The majority are atherosclerotic in origin. The primary complication is myocardial ischemia or infarction, sudden cardiac death with rupture being rare. Some aneurysms are diagnosed incidentally in arteries other than the culprit artery. Treatment options include medical management with anticoagulation, percutaneous intervention with covered stents or surgery...
October 2018: Cardiology Research
Orathai Pachirat, Danon Kaewkes, Burabha Pussadhamma, George Watt
Infective endocarditis due to non-toxigenic Corynebacterium diphtheriae is uncommon. We describe the case of a 42-year-old male with a history of mitral valve replacement with prosthetic valve for 4 years. He presented with fever, weight loss, dyspnea on exertion and orthopnea. The echocardiography demonstrated large vegetation attached on the left coronary cusp of the aortic valve with moderately severe aortic regurgitation but sparing of the prosthetic mitral valve. Three separate blood cultures grew Corynebacterium species...
October 2018: Cardiology Research
Poornima Vinod, Ahmad Jabri, Vinayak Hegde, Joseph Lahorra, David Cutler
Cardiac intimal sarcomas are extremely rare, remarkably aggressive and least reported type of primary malignant tumors of the heart. Cardiac intimal sarcomas are encountered more commonly in the large arterial blood vessels including pulmonary artery and aorta, and are extremely rare in the heart. The mainstay of treatment is achievement of tumor-free margins with surgical resection, which is associated with improved survival. Here, we report a 66-year-old female with primary cardiac intimal sarcoma presented with functional mitral stenosis and heart failure...
October 2018: Cardiology Research
Flavia Myrna, Dinaldo C Oliveira, Gloria Vinhas, Ivo Silva, Magno Teixeira, Andre Galembeck
Background: Catheters are extensively used for coronary angiographies. These devices are long, thin, and flexible tubes of variable diameters that are made of the following polymer compounds: polyamide, polyurethane and Teflon. The objectives of this study are to identify changes that occur in the polymeric structure of the catheters, including an analysis of microcracks, fissures, cuts, perforations, roughness, and porosity in the internal and external layers after the first, second, third, and seventh reprocessing...
October 2018: Cardiology Research
Omar Chehab, Abdul Salam Qannus, Mahmoud Eldirani, Hussein Hassan, Hani Tamim, Habib A Dakik
Background: Limited data are available on the predictors of mortality in patients hospitalized with acute myocardial infarction (AMI) in developing countries. In this study, we analyze the predictors for in--hospital mortality in patients hospitalized with AMI (ST segment elevation myocardial infarction (STEMI) and non-ST-elevation myocardial infarction (NSTEMI)) in a large tertiary referral university hospital in Lebanon. Methods: This was a retrospective study of 503 patients admitted to the American University of Beirut Medical Center with AMI (228 with STEMI and 275 with NSTEMI)...
October 2018: Cardiology Research
Bhupendra Verma, Amrita Singh, Ashwani K Saxena, Manu Kumar
Background: Several studies and meta-analyses have shown that direct stenting (DS) may improve clinical outcomes in patients with acute ST-elevation myocardial infarction (STEMI). But in most cases, the thrombolysis in myocardial infarction (TIMI) flow remains ≤ 1 after wire placement. We used deflated balloon to facilitate DS in patients with totally occluded culprit arteries. The aim of this study was to evaluate the feasibility, safety and outcomes of this novel technique in patients with STEMI in real-world clinical practice...
October 2018: Cardiology Research
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