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Journal of International Advanced Otology

Teruo Toi, Yasuyuki Nomura, Akihiro Kishino, Shuntaro Shigihara, Takeshi Oshima, Harumi Ishikawa, Satoshi Kamei, Hidemi Miyazaki
Cases of dizziness caused by multiple sclerosis are commonly reported, but those caused by mitochondrial encephalomyopathy have been rarely reported. Particularly, the description of eye nystagmography (ENG) using caloric and optokinetic nystagmus tests has not been reported to date. We encountered the case of a 40-year-old woman with mitochondrial encephalomyopathy who visited us with the chief complaint of dizziness. At first, we considered multiple sclerosis based on the magnetic resonance imaging (MRI) findings and dizziness...
February 20, 2018: Journal of International Advanced Otology
Philippe Perrin, Art Mallinson, Christian Van Nechel, Laetitia Peultier-Celli, Hannes Petersen, Mans Magnusson, Herman Kingma, Raphaël Maire
The European Society for Clinical Evaluation of Balance Disorders - ESCEBD - Executive Committee meets yearly to identify and address clinical equilibrium problems that are not yet well understood. This particular discussion addressed "discordances" (defined as "lack of agreement") in clinical assessment. Sometimes there is disagreement between a clinical assessment and measured abnormality (ies); sometimes the results within the assessment do not agree. This is sometimes thought of as "malingering" or an attempt to exaggerate what is wrong, but this is not always the case...
February 20, 2018: Journal of International Advanced Otology
Engin Kara, Kübra Öztürk, Ezgi Oktay, Vural Hamzaoğlu, Deniz Uzmansel, Yusuf Vayisoğlu, Hakan Özalp, Mehmet Farsak, Zeynep Cansu Aladağ, Tuğçe Pütürgeli, Can Mehmet Eti, Ahmet Dağtekin, Merve Türkegün, Derya Ümit Talas
OBJECTIVE: There is still ongoing research on the relationship of arcuate eminence (AE) and superior semicircular canal (SSC). We aimed to evaluate the precision of predictability of SSC through the morphology of AE via radiological means. MATERIALS AND METHODS: This investigation is performed on 12 dry skulls belonging to Mersin University Medical Faculty department of anatomy. Computed tomography (CT) assessment is performed with 0.5-mm-thin sections temporal bone algorithm on dry skulls which were marked with fixated copper wire by scotch tapes on the most prominent part of the middle fossa floor assuming the location of AE...
February 20, 2018: Journal of International Advanced Otology
Efe Serinan, Zekiye Altun, Safiye Aktaş, Emre Çeçen, Nur Olgun
OBJECTIVE: Cisplatin (CDDP) is an anti-neoplastic agent that has been used in treatments of both pediatric and adult cancers. It has many side effects, such as ototoxicity, nephrotoxicity, and neurotoxicity. Lipoplatin (LIPO) is a nanomolecule with 110 nm diameter and composed of lipids and CDDP. In this study, we aimed to compare the toxic effects of LIPO with CDDP in the cochlear cells with anti-tumoral doses determined in neuroblastoma cells. MATERIALS AND METHODS: House Ear Institute Organ Corti 1 (HEI-OC1), MYC-N amplified KELLY, and MYC-N non-amplified SH-SY5Y human neuroblastoma cells were used in this study...
February 20, 2018: Journal of International Advanced Otology
Miray Sözen, Işılay Öz, Selim Erbek
OBJECTIVE: Multifrequency tympanometry (MFT) analyzes tympanograms obtained using different probe tones between 226 and 2000 Hz. An important parameter of MFT is resonance frequency (RF). Studies have recently demonstrated that the RF value can vary depending on many factors. To provide new data regarding MFT, middle ear RF values were investigated with regard to body mass index (BMI). MATERIALS AND METHODS: This study included 78 volunteers (i.e., 156 ears) aged 18-40 years who did not have hearing loss and whose otoscopic examinations were normal...
February 20, 2018: Journal of International Advanced Otology
Arthur Mallinson, Anouk Kuijpers, Neil Longridge
OBJECTIVE: Ocular vestibular-evoked myogenic potentials (OVEMPs) in our hands provide us with reproducible and consistent results; however, it has been shown that the OVEMP amplitude decreases with increased stimulus duration. The exact number of stimuli for OVEMP recording is not consistent among the published papers describing this test. We aimed to determine the number of stimuli needed to produce a satisfactory OVEMP response and the consequences of a more prolonged stimulation to the OVEMP response...
February 20, 2018: Journal of International Advanced Otology
Per Cayé-Thomasen
No abstract text is available yet for this article.
February 20, 2018: Journal of International Advanced Otology
Massimo Ralli, Antonio Greco, Marco de Vincentiis
No abstract text is available yet for this article.
December 14, 2017: Journal of International Advanced Otology
Said Sönmez, Bayram Şahin, Beldan Polat, Şenol Çomoğlu, Kadir Serkan Orhan
Spontaneous cerebrospinal fluid (CSF) otorrhea frequently occurs without temporal bone trauma, fracture, surgery, or any identifiable causes. It is usually associated with tegmen tympani defects of the temporal bone in adults. The congenital origin theory and the arachnoid granulation theory have been accepted to explain the tegmen tympani defect. Magnetic resonance imaging (MRI) and computed tomography (CT) are used to show the defects, brain tissue, and the meninges. We recently encountered three cases of spontaneous CSF otorrhea with a defect on the tegmental plate of the temporal bone...
December 14, 2017: Journal of International Advanced Otology
Hiroshi Moriyama, Nobuyuki Mitsukawa, Masahiro Itoh, Naruhito Otsuka
OBJECTIVE: Details regarding the molecular biological features of Bell's palsy have not been widely reported in textbooks. We genetically analyzed facial muscles and clarified these points. MATERIALS AND METHODS: We performed genetic analysis of facial muscle specimens from Japanese patients with severe (House-Brackmann facial nerve grading system V) and moderate (House-Brackmann facial nerve grading system III) dysfunction due to Bell's palsy. Microarray analysis of gene expression was performed using specimens from the healthy and affected sides, and gene expression was compared...
December 14, 2017: Journal of International Advanced Otology
Başak Mutlu, Günay Kırkım, Serpil Mungan Durankaya, Selhan Gürkan, Tahsin Oğuz Başokçu, Enis Alpin Güneri
OBJECTIVE: Ménière's Disease (MD) is a chronic, non-life threatening inner ear disease, with attacks of disabling vertigo, progressive hearing loss, and tinnitus as the major symptoms. All three symptoms, separately or in combination, cause great distress and have a considerable impact on the quality of life of the patients. The aims of this study were to develop a disease-specific quality of life survey for patients with MD and to analyze the relationships between the audiovestibular findings and the survey...
December 14, 2017: Journal of International Advanced Otology
Fatma Beyazal Çeliker, Abdulkadir Özgür, Metin Çeliker, Mehmet Beyazal, Arzu Turan, Suat Terzi, Mehmet Fatih İnecikli
OBJECTIVE: This study aimed to evaluate the efficacy of magnetic resonance imaging (MRI) for diagnosing superior semicircular canal dehiscence (SSCD). MATERIALS AND METHODS: The radiological records of patients who were admitted to our clinic with complaints of otologic and neuro-otologic symptoms between October 2014 and December 2015 were retrospectively reviewed. Among these patients, those who underwent both computed tomography and MRI and were reported to have SSCD in the temporal bone on at least one side were included in the study group...
December 14, 2017: Journal of International Advanced Otology
Emre Ocak, Deniz Kocaöz, Baran Acar, Selma Uysal Ramadan, Melih Topçuoğlu
OBJECTIVE: The objective of this research was to investigate the possible relationship between tinnitus and certain bony inner ear structures using computed tomography (CT). MATERIALS AND METHODS: This was a prospective, controlled, double-blind study. The subjects of the study were divided into the following three groups: group 1 (G1), patients with unilateral sensorineural hearing loss (SNHL) and unilateral non-pulsatile tinnitus in the same ear; group 2 (G2), patients with normal hearing and unilateral non-pulsatile tinnitus; and group 3 (G3), healthy volunteers with neither tinnitus nor hearing loss...
December 14, 2017: Journal of International Advanced Otology
Oğuz Kadir Eğilmez, Numan Kökten, Mustafa Baran, M Tayyar Kalcıoğlu, Işın Doğan Ekici, Muhammet Tekin
OBJECTIVE: Sodium-2-mercaptoethanesulfonate (MESNA) is widely used in medicine because of its antioxidant and mucolytic effects. In recent years, it has been used in otologic surgery. Because it cleaves disulfide bonds, it is used to easily dissect the epithelial matrix in cholesteatoma and atelectasis. In this study, we hypothesized that MESNA does not have any toxic effect on the facial nerve, and the effects of MESNA on the facial nerve were examined histologically and electrophysiologically...
December 14, 2017: Journal of International Advanced Otology
Mehmet Akif Aksoy, Mustafa Fuat Açıkalın, Melek Kezban Gürbüz, Erkan Niyazi Özüdoğru, Funda Canaz, Ercan Kaya, Mehmet Özgür Pınarbaşlı, Armağan İncesulu, Hamdi Çaklı, Cemal Cingi
OBJECTIVE: We investigated the use of autologous platelet-rich plasma (PRP) to improve the success rate of fat graft myringoplasty in perforated tympanic membranes of rats. MATERIALS AND METHODS: A total of 20 healthy Wistar albino female rats were divided into two groups. In Group 1, the left tympanic membranes were perforated and grafted with a fat graft that was harvested from the inguinal region. In Group 2, the left tympanic membranes were perforated, and a fat graft was also harvested from the inguinal region...
December 14, 2017: Journal of International Advanced Otology
Hasan Demirel, Cengiz Arlı, Tümay Özgür, Melek İnci, Recep Dokuyucu
OBJECTIVE: The aim of this experimental study was to compare the dose-related effect of topical thymoquinone (TQ) with other topical agents used in the management of acute otitis externa (AOE) in a rat model. MATERIALS AND METHODS: Forty-eight male Wistar albino rats were divided into six groups each with eight rats per group. Group I was the control group with no external otitis, whereas external otitis were created in the other five groups (study groups). Dexamethasone, 0...
December 14, 2017: Journal of International Advanced Otology
Nehal Mamdouh Abd El Salam, Elshahat Ibrahem Ismail, Ayman El Saeed El Sharabasy
OBJECTIVE: Noise has been recognized as a major cause of cochlear damage resulting in both tinnitus and hearing loss. On the other hand, damage to the vestibular system, especially the saccule, can be considered as a potential problem. The cervical vestibular-evoked myogenic potentials (cVEMPs) have been established as a clinical test of measuring both sac-cular and inferior vestibular nerve function. Therefore, it is thought to be sensitive to the noise-induced damage to the vestibular system...
December 14, 2017: Journal of International Advanced Otology
Ioannis Kastanioudakis, Panagiotis Saravakos, Andreas Zigouris, Vasileios Ragos, Oliver Reichel, Nafsika Ziavra
OBJECTIVE: Cervical spondylosis and cervical disk herniation are the most frequent forms of degenerative disease in the cervical spine. Surgical treatment mainly includes anterior cervical disk fusion. However, information concerning vestibular-evoked myogenic potential (VEMP) recording in patients undergoing cervical spine surgery is limited. The present prospective study aimed to investigate the effect of anterior disk fusion surgery on cervical VEMP (cVEMP) parameters. MATERIALS AND METHODS: Twenty-five patients were enrolled in this study, and 20 patients (10 men and 10 women) completed cVEMP testing...
December 14, 2017: Journal of International Advanced Otology
Edoardo Covelli, Guido Trasimeni, Chiara Filippi, Valerio Fabiani, Simonetta Monini, Luigi Volpini, Maurizio Barbara
To the best of our knowledge, only 2 cases of a simultaneous contralateral vestibular schwannoma (VS) and middle ear paraganglioma (MEP) have previously been reported in literature. We report the third case observed in a 43-year-old male, who presented with an 11-year history of right-sided hearing loss and a 1-year history of left-sided pulsatile tinnitus. A magnetic resonance imaging (MRI) showed a VS on the right side and computer tomography (CT) identified a Fisch type A1 paraganglioma on the left side...
December 2017: Journal of International Advanced Otology
Michele Ori, Mario Faralli, Giampietro Ricci
Paradoxical embolization is the most commonly proposed mechanism for ischemia in patients with patent foramen ovale (PFO). We hypothesize that these patients can experience a microembolic genesis of cochleovestibular dysfunction, with a peripheral vestibular syndrome and simultaneous cochlear signs. Hence, we report the first case in literature associating PFO and acute transitory audiovestibular loss, which occurred in a male who had had an ischemic mesencephalic stroke several months ago. The patient's history and duration of the current event of less than 24 hours following complete functional recovery without any damage highlight the vascular cause in cochleovestibular dysfunction and support the existence of a clinical entity that could be named "cochleovestibular transient ischemic attack"...
December 2017: Journal of International Advanced Otology
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