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Central-European Journal of Immunology

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https://www.readbyqxmd.com/read/29204100/interaction-and-cellular-uptake-of-surface-modified-carbon-dot-nanoparticles-by-j774-1-macrophages
#1
Lester Thoo, Mochamad Z Fahmi, Ihsan N Zulkipli, Natasha Keasberry, Adi Idris
Carbon dot (Cdot) nanoparticles are an emerging class of carbon nanomaterials with a promising potential for drug delivery and bio imaging applications. Although the interaction between Cdots and non-immune cell types has been well studied, Cdot interactions with macrophages have not been investigated. Exposure of Cdot nanoparticles to J774.1 cells, a murine macrophage cell line, resulted in minimal toxicity, where notable toxicity was only seen with Cdot concentrations higher than 0.5 mg/ml. Flow cytometric analysis revealed that Cdots prepared from citric acid were internalized at significantly higher levels by macrophages compared with those prepared from bamboo leaves...
2017: Central-European Journal of Immunology
https://www.readbyqxmd.com/read/29204099/tuberculosis-infection-in-children-with-proteinuria-nephrotic-syndrome
#2
Hanna Szymanik-Grzelak, Elżbieta Kuźma-Mroczkowska, Piotr Skrzypczyk, Teresa Bielecka, Iwona Kotula, Małgorzata Pańczyk-Tomaszewska
Children with nephrotic syndrome (NS) are at greater risk of infections than the general population, due to immunodeficiency in the course of the disease and the treatment. In this study we present 4 children (2 girls, 2 boys), mean age 7.6 ±5.1 years, with NS/proteinuria and latent tuberculosis in 3 children and lymph node tuberculosis in 1 child. The reasons for testing these children for tuberculosis (TB) were the evaluation of the epidemiological status before treatment with corticosteroids (GCS), leukopenia and the relapse of NS, and non-nephrotic proteinuria...
2017: Central-European Journal of Immunology
https://www.readbyqxmd.com/read/29204098/effectiveness-of-rituximab-in-nephrotic-syndrome-treatment
#3
Katarzyna Popko, Elżbieta Górska, Elżbieta Kuźma-Mroczkowska
Idiopathic nephrotic syndrome (INS) is a common chronic illness characterized by massive proteinuria and hypo-albuminemia in children. Baseline treatment is 6 month-corticotherapy. In cases of steroid resistant/dependent INS several types of treatment are used, including course of methyloprednisolone "pulses", alkylating agents, cyclosporin A, levamisole and mycophenolate mofetil. It has been suggested that children with frequently relapsing nephrotic syndrome or steroid-dependent nephrotic syndrome had a significantly longer relapse-free period if rituximab (RTX) treatment was additionally applied...
2017: Central-European Journal of Immunology
https://www.readbyqxmd.com/read/29204097/air-pollution-oxidative-stress-and-exacerbation-of-autoimmune-diseases
#4
REVIEW
Anna Gawda, Grzegorz Majka, Bernadeta Nowak, Janusz Marcinkiewicz
A number of epidemiological studies have shown a strong association between exposure to ambient airborne particulate matter (PM 2.5, PM < 1.0) and lung or cardiovascular diseases characterised by high mortality and morbidity. However, much less is known about the role of air pollution in the pathogenesis of autoimmune diseases, which constitutes a significant problem in modern society. This paper summarises the state of current research regarding the influence of PM on the development and/or progression of autoimmune diseases...
2017: Central-European Journal of Immunology
https://www.readbyqxmd.com/read/29204096/interference-rna-in-immune-mediated-oral-diseases-minireview
#5
REVIEW
Raghu Dhanapal, Sreepallavi Somasundarapandian, Sosroseno Wihaskoro, Ranganathan Kannan, Govind Rajkumar, Ramasamy Chidambaram
Immune-mediated oral disorders are characterised by their chronicity, and some are refractory to treatment. Interference RNA (iRNA) has been implicated in the underlying mechanism of such immune-mediate oral and refractory inflammatory oral diseases. iRNA-based understanding of the mechanism in these diseases may help to produce non-invasive diagnostic methodologies and treatment modalities of such drug non-responsive diseases. Oral lesions in these immune-mediated diseases can precede the occurrence of lesions in other regions of the body...
2017: Central-European Journal of Immunology
https://www.readbyqxmd.com/read/29204095/immune-disorders-in-anorexia
#6
REVIEW
Sylwia Małgorzata Słotwińska, Robert Słotwiński
Anorexia nervosa is a disease involving eating disorders. It mainly affects young people, especially teenage women. The disease is often latent and occurs in many sub-clinical and partial forms. Approximately from 0.3% to 1% of the population suffers from anorexia. It has been shown that patients with anorexia develop neurotransmitter-related disorders, leading to uncontrolled changes in the immune and endocrine systems. Interactions between cytokines, neuropeptides, and neurotransmitters play an important role in disease development...
2017: Central-European Journal of Immunology
https://www.readbyqxmd.com/read/29204094/the-significance-of-il-1%C3%AE-3953c-t-il-6-174g-c-and-596g-a-tnf-%C3%AE-308g-a-gene-polymorphisms-and-86-bp-variable-number-tandem-repeat-polymorphism-of-il-1rn-in-bronchopulmonary-dysplasia-in-infants-born-before-32-weeks-of-gestation
#7
Dawid Szpecht, Janusz Gadzinowski, Irmina Nowak, Dorothy Cygan, Agnieszka Seremak-Mrozikiewicz, Grażyna Kurzawińska, Dariusz Madajczak, Krzysztof Drews, Marta Szymankiewicz
Introduction: Bronchopulmonary dysplasia (BPD) is a chronic lung disease that affects primarily preterm infants. Genetic factors are also taken into consideration in the pathogenesis of BPD. Genetic predispositions to higher production of inflammation mediators seem to be crucial. Material and methods: The aim of this study was to evaluate the possible relationship between polymorphisms: interleukin-1β +3953 C>T, interleukin-6 -174 G>C and -596 G>A, tumour necrosis factor -308 G>A and interleukin-1RN VNTR 86bp and the occurrence of BPD in a population of 100 preterm infants born from singleton pregnancy, before 32+0 weeks of gestation, exposed to antenatal steroids therapy, and without congenital abnormalities...
2017: Central-European Journal of Immunology
https://www.readbyqxmd.com/read/29204093/evaluation-of-the-adenosine-deaminase-ada-g22a-gene-polymorphism-with-recurrent-spontaneous-abortion-among-egyptian-patients
#8
Hanan Mohamed Farhan, Khadiga Abu-Gabal, Maha Katta, Raghda Ibrahim
Introduction: Adenosine and deoxyadenosine metabolism is influenced by adenosine deaminase (ADA) enzyme. ADA increases in different diseases and is considered as one of the markers for cell-mediated immunity. Pregnancy is associated with depressed cell-mediated immunity. The level of ADA expression, which seems to play a key role in maintaining pregnancy, is influenced by adenosine deaminase G22A gene polymorphism. We aimed in our study to evaluate the association of ADA G22A gene polymorphism with recurrent spontaneous abortion (RSA) in Egyptian women...
2017: Central-European Journal of Immunology
https://www.readbyqxmd.com/read/29204092/effect-of-perinatal-risk-factors-on-neutrophil-gelatinase-associated-lipocalin-ngal-level-in-umbilical-and-peripheral-blood-in-neonates
#9
Agnieszka Kisiel, Maria Roszkowska-Blaim, Małgorzata Pańczyk-Tomaszewska, Anna Stelmaszczyk-Emmel, Elżbieta Górska, Maria Borszewska-Kornacka
Introduction: Acute kidney injury biomarkers are opening a new era in diagnosing kidney failure. The requirement for a specific and sensitive marker of kidney function is highly desirable in neonates because the diagnostic possibilities in this age group are not sufficient. Recent research show that neutrophil gelatinase-associated lipocalin (NGAL) can have a great potential but there is a wide range of medical conditions, that may influence their expression. The aim of the study: was to evaluate the impact of perinatal risk factors on NGAL level in neonates...
2017: Central-European Journal of Immunology
https://www.readbyqxmd.com/read/29204091/lipocalin-2-as-a-clinical-significance-in-rheumatoid-arthritis
#10
Arif Gulkesen, Gurkan Akgol, Ahmet K Poyraz, Suleyman Aydin, Affan Denk, Tulay Yildirim, Arzu Kaya
Aim of the study: In this study, serum lipokalin 2 (LCN-2) levels and its clinical and radiological significance in patients with rheumatoid arthritis was evaluated. Material and methods: The study enrolled 37 patients with RA and 34 healthy controls. Serum LCN-2 level was measured using ELISA method. Patients with DAS 28 scores ≤ 3.2, and > 3.2 were allocated into lower and high/moderate disease activity groups, respectively. Additionally patients were divided into 2 groups as early RA (disease duration ≤ 2 years) and established RA (duration of the disease ≥ 2 years)...
2017: Central-European Journal of Immunology
https://www.readbyqxmd.com/read/29204090/autoantibodies-c-reactive-protein-erythrocyte-sedimentation-rate-and-serum-cytokine-profiling-in-monitoring-of-early-treatment
#11
Edyta Brzustewicz, Izabella Henc, Agnieszka Daca, Maria Szarecka, Malgorzata Sochocka-Bykowska, Jacek Witkowski, Ewa Bryl
Introduction: Currently used clinical scale and laboratory markers to monitor patients with early rheumatoid arthritis (RA) seem to be not sufficient. It has been demonstrated that disease- related cytokines may be elevated very early in RA development and cytokines are considered as the biomarkers potentially useful for RA monitoring. Material and methods: The group of patients with undifferentiated arthritis (UA) developing RA (UA→RA) was identified from a total of 121 people with arthralgia...
2017: Central-European Journal of Immunology
https://www.readbyqxmd.com/read/29204089/subpopulations-of-natural-killer-t-like-cells-before-and-after-surgical-treatment-of-laryngeal-cancer
#12
Janusz Klatka, Ewelina Grywalska, Anna Hymos, Ewelina Krasowska, Michał Mielnik, Dorota Siwicka-Gieroba, Justyna Markowicz, Piotr Trojanowski, Witold Olszański, Jacek Roliński
Introduction: Tumours connected with head and neck comprise about 5% of all tumours. The most frequent histological type of laryngeal carcinoma is squamous cell carcinoma. Different research projects suggest that the role of T lymphocytes might be significant in tumour development. iNKT cells are a new subpopulation of T cells and show cytotoxic activity against tumours. iNKT cells participate in modulating the function of other cells which have anti-tumour properties and secrete cytokines, which have pro-inflammatory and anti-inflammatory effects...
2017: Central-European Journal of Immunology
https://www.readbyqxmd.com/read/29204088/terminally-differentiated-memory-t-cells-are-increased-in-patients-with-common-variable-immunodeficiency-and-selective-iga-deficiency
#13
Jana Nechvatalova, Tomas Pavlik, Jiri Litzman, Marcela Vlkova
Introduction: Previous studies showed that several lymphocyte abnormalities seen in the most frequent symptomatic immunoglobulin deficiency, common variable immunodeficiency (CVID), were also observed in a genetically related asymptomatic disorder - selective IgA deficiency (IgAD). In this study we searched for abnormalities in the differentiation stages of T cells as well as for similarities of these abnormalities in CVID and IgAD patients. Material and methods: Using flow cytometry in 80 patients with IgAD, 48 patients with CVID, and 80 control persons we determined T-lymphocyte subsets: both CD4 and CD8 were divided into the naïve CD45RO-CD27+, early differentiated CD45RO+CD27+, late differentiated CD45RO+CD27- and fully differentiated effector CD45RO-CD27- memory T cells, as well as Treg cells, defined as CD4+CD25highCD127low T cells...
2017: Central-European Journal of Immunology
https://www.readbyqxmd.com/read/29204087/the-effect-of-aeromonas-hydrophila-infection-on-the-non-specific-immunity-of-blunt-snout-bream-megalobrama-amblycephala
#14
Hu Xia, Ying Tang, Fenghui Lu, Yushuang Luo, Pinhong Yang, Wenbin Wang, Jigang Jiang, Na Li, Qing Han, Fei Liu, Lianggvo Liu
Aeromonas hydrophila is the main reason of epidemic septicaemia for freshwater fish. In the present study, the effect of Aeromonas hydrophila infection on the non-specific immunity of blunt snout bream (Megalobrama amblycephala) was studied. After Aeromonas hydrophila challenge, lysozyme activity was significantly increased at 4 h, 1 d, 3 d, 5 d, 14 d and 21 d. An increased level of lysozyme activity indicated a natural protective mechanism in fish. The significant increases of superoxide dismutase activity and catalase activity in treatment group were detected at 4 h, 1 d, 3 d, 5 d, 14 d and 21 d after Aeromonas hydrophila challenge...
2017: Central-European Journal of Immunology
https://www.readbyqxmd.com/read/29204086/immunomodulatory-effect-of-moringa-peregrina-leaves-ex-vivo-and-in-vivo-study
#15
Ibrahim Salameh Al-Majali, Sawsan Atallah Al-Oran, Mona Rushdie Hassuneh, Haitham Naief Al-Qaralleh, Walid Abu Rayyan, Osama Yosef Al-Thunibat, Eyad Mallah, Ahmed Abu-Rayyan, Shadi Salem
This study was conducted to assess the in vivo and ex vivo immunomodulatory effect of the ethanol leaves extract of Moringa peregrina in Balb/c mice. For this study, five groups of 5 Balb/c mice were given a single acute subtoxic oral dose of the ethanolic extract at 1.13, 11.30, 23.40 and 113.4 mg/kg and the immunomodulatory effect was assessed on the 6th day following the ingestion. In the (non-functional) assessment, the effect of the extract on the body weight, relative lymphoid organ weight, splenic cellularity and peripheral blood hematologic parameters were evaluated...
2017: Central-European Journal of Immunology
https://www.readbyqxmd.com/read/29204085/immune-complex-negatively-regulates-toll-like-receptor-3-triggered-tumour-necrosis-factor-%C3%AE-production-in-b-cells
#16
Li Qian, Wenyan Chen, Shaoqing Wang, Yang Liu, Xiaoqin Jia, Yi Fu, Weijuan Gong, Fang Tian
Inappropriate activation of toll-like receptor 3 (TLR3) has been implicated in the pathogenesis of autoimmune diseases, so the negative regulation of TLR3-triggered immune response has received increasing attention. Nonpathogenic immune complex (IC) has been used as treatment for many inflammatory and autoimmune diseases. However, the role of IC in the regulation of TLR3-triggered immune responses and the underlying mechanisms need to be investigated. In this study we demonstrate that IC or intravenous immunoglobulin (Ig) stimulation of B cells attenuates polyinosinic:polycytidylic acid (poly I:C)-induced CD40 expression; IC, but not Ig, can significantly inhibit poly I:C-induced pro-inflammatory tumour necrosis factor α (TNF-α) production by B cells...
2017: Central-European Journal of Immunology
https://www.readbyqxmd.com/read/28867962/vaccine-research-and-development-tuberculosis-as-a-global-health-threat
#17
REVIEW
Mohammed Maikudi Usman, Salmah Ismail, Teow Chong Teoh
One of the aims of the World Health Organisation (WHO) Millennium Development Goals (MDG) is to reduce the number of cases of tuberculosis (TB) infection by the year 2015. However, 9 million new cases were reported in 2013, with an estimated 480,000 new cases of multi-drug resistant tuberculosis (MDR-TB) globally. Bacille Calmette-Guérin (BCG) is the most available and currently used candidate vaccine against tuberculosis; it prevents childhood TB, but its effectiveness against pulmonary TB in adults and adolescents is disputed...
2017: Central-European Journal of Immunology
https://www.readbyqxmd.com/read/28867961/potential-immunotoxic-effects-of-trichloroethylene-induced-iv-allergic-reaction-in-renal-impairment
#18
Jun-Feng Yu, Yan-Yan Feng, Xiao-Feng Shen
Trichloroethylene (TCE) is known to induce allergic contact dermatitis and subsequent occupational medicamentosa-like dermatitis (OMLD) with multi-system injuries, including liver, kidney, and skin injuries. However, the mechanisms underlying immune system dysfunction that result in organ injury have not yet been clearly elucidated. In the present study, we measured the levels of secreted cytokines by effect or T cells in TCE-treated guinea pigs to better understand the contribution of allergic disorders in renal injuries...
2017: Central-European Journal of Immunology
https://www.readbyqxmd.com/read/28860941/dengue-virus-and-japanese-encephalitis-virus-infection-of-the-central-nervous-system-share-similar-profiles-of-cytokine-accumulation-in-cerebrospinal-fluid
#19
Haipeng Li, Yuanyuan Li, Bo Wen, Jian Zhang, Chengwu Wang, Zhanyi Song, Shuochi Li, Xiaowang Qu, Renbin Huang, Wenpei Liu
Dengue virus (DENV) and Japanese encephalitis virus (JEV) are two important pathogenic viruses that can cause severe encephalitis, which is accompanied by inflammatory cytokines. However, the inflammatory cytokine content of cerebrospinal fluid (CSF) in DENV and JEV infection of central nervous system are not sufficiently studied. To investigate cytokine levels in serum and CSF of hospitalised children with DENV and JEV infection of the central nervous system, a total of 183 hospitalised children with viral encephalitis-like syndrome were enrolled between May 2014 and April 2015 at the Children's Hospital of Chenzhou, Hunan, China...
2017: Central-European Journal of Immunology
https://www.readbyqxmd.com/read/28860940/limbic-encephalitis-a%C3%A2-report-of-four-cases
#20
Żanna Pastuszak, Adam Stępień, Kazimierz Tomczykiewicz, Renata Piusińska-Macoch, Joanna Kordowska, Dariusz Galbarczyk, Jarosław Świstak
Usually limbic encephalitis (LE) is a paraneoplastic neurologic syndrome. LE symptoms can precede cancer even by a few years. Almost 50% of LE cases are connected with small cell lung carcinoma. Testis and breast cancers, granulomatous disease, thymoma, and teratomas are also often connected with LE. Other cases have infectious and autoimmunological aetiology. In LE limbic system dysfunction is observed, and it is accompanied by cerebellum and brain stem abnormalities as well as polyneuropathy. Paraneoplastic limbic encephalitis is sometimes a part of larger syndrome in which brain stem and spinal cord are involved in an inflammatory process called paraneoplastic encephalomyelitis...
2017: Central-European Journal of Immunology
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