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Central-European Journal of Immunology

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https://www.readbyqxmd.com/read/28450807/coronins-and-their-role-in-immunological-phenomena
#1
REVIEW
Beata Tokarz-Deptuła, Magdalena Malinowska, Mateusz Adamiak, Wiesław Deptuła
Coronins are a large family of proteins occurring in many eukaryotes. In mammals, seven coronin genes have been identified, evidencing that coronins 1 to 6 present classic coronin structure, while coronin 7 is a tandem coronin particle, without a spiral domain, although the best characterised coronin, in terms of both structure and function, is the mammalian coronin 1. It has been proven that they are related to regulation of actin dynamics, e.g. as a result of interaction with the complex of proteins Arp2/3...
2016: Central-European Journal of Immunology
https://www.readbyqxmd.com/read/28450806/micrornas-as-regulators-of-drug-abuse-and-immunity
#2
REVIEW
Kai Zhang, Xuxiu Jing, Guoqiang Wang
MicroRNAs (miRNAs) are 20-22 nucleotide non-coding RNAs that participate in gene regulation. They bind to 3'-untranslated regions of their mRNA targets, inhibiting the transcripts' translation and/or destabilizing them. Chronic drug abuse induces changes of miRNAs expression in the brain, which is thought to contribute to addictive behaviors. Lots of miRNAs have been identified to play critical roles in the development of drug addiction. Moreover, miRNAs have been shown to play critical roles in a broad array of biologic processes, including regulation of the cell cycle, oncogenic transformation, immune cell regeneration and differentiation, and psychiatry disorders...
2016: Central-European Journal of Immunology
https://www.readbyqxmd.com/read/28450805/endogenous-antimicrobial-factors-in-the-treatment-of-infectious-diseases
#3
REVIEW
Paulina Żelechowska, Justyna Agier, Ewa Brzezińska-Błaszczyk
Nowadays, a number of antibiotic-resistant bacteria strains is increasing. It is a serious clinical problem and poses a threat to the effectiveness of conventional antibiotic therapy. Thus, scientists are constantly seeking new alternatives for treatment of infectious diseases. There are some natural endogenous factors, which possess antimicrobial activities against a large number of microorganisms, including both Gram-positive and Gram-negative bacteria, viruses and fungi. These factors are present in all eukaryotic organisms and constitute an essential element of their immune system...
2016: Central-European Journal of Immunology
https://www.readbyqxmd.com/read/28450804/dysregulation-of-signaling-pathways-associated-with-innate-antibacterial-immunity-in-patients-with-pancreatic-cancer
#4
REVIEW
Robert Słotwiński, Sylwia Małgorzata Słotwińska
Disorders of innate antibacterial response are of fundamental importance in the development of gastrointestinal cancers, including pancreatic cancer. Multi-regulatory properties of the Toll-like receptors (TLRs) (e.g., regulation of proliferation, the activity of NF-κB, gene transcription of apoptosis proteins, regulation of angiogenesis, HIF-1α protein expression) are used in experimental studies to better understand the pathogenesis of pancreatic cancer, for early diagnosis, and for more effective therapeutic intervention...
2016: Central-European Journal of Immunology
https://www.readbyqxmd.com/read/28450803/diagnostic-value-of-selected-markers-and-apoptotic-pathways-for-pancreatic-cancer
#5
REVIEW
Robert Słotwiński, Sylwia Małgorzata Słotwińska
Pancreatic cancer occupies the fourth place as a cause of death from cancer, and the mortality rate is similar to the number of newly detected cases. Due to the late diagnosis, only 5-6% of patients with pancreatic cancer survive for five years. Given that early diagnosis is critical for improving patients' survival rates, there is an urgent need for the discovery and validation of new biomarkers with sufficient sensitivity and specificity to help diagnose pancreatic cancer early. Detection of serum tumor markers (CA19-9, CEA, CA125 and CA242) is conducive to the early diagnosis of pancreatic cancer...
2016: Central-European Journal of Immunology
https://www.readbyqxmd.com/read/28450802/neutrophil-to-lymphocyte-ratio-is-associated-with-proximal-middle-segment-of-the-lad-lesions-in-patients-with-st-segment-elevation-infarction
#6
Ozlem Arican Ozluk, Mustafa Yılmaz, Dursun Topal, Erhan Tenekecioglu, Tezcan Peker, Selcuk Kanat, Kemal Karaagac, Fahriye Vatansever, Utku Parlak
INTRODUCTION: Neutrophil to lymphocyte ratio (NLR) was revaled to have a close relation with atherosclerotic cardiovascular disease. The relationship between NLR and culprit plaque localization has never been studied. AIM OF THE STUDY: To evaluate the association between NLR and unstable plaque localization of left anterior descending artery (LAD) in anterior miyocardial infarction patients. MATERIAL AND METHODS: Patients admitted to our hospital with acute anterior STEMI were included...
2016: Central-European Journal of Immunology
https://www.readbyqxmd.com/read/28450801/no-evidence-of-west-nile-virus-infection-among-polish-patients-with-encephalitis
#7
Joanna Jabłońska, Marta Popiel, Iwona Bukowska-Ośko, Karol Perlejewski, Kamila Caraballo Cortés, Andrzej Horban, Urszula Demkow, Tomasz Laskus, Marek Radkowski
West Nile virus (WNV) infection usually causes mild febrile illness, but in a small proportion of patients it can lead to encephalitis. Epidemiological studies of WNV indicate fast spread of infection worldwide and in Europe, but there have been no comprehensive studies of WNV infection among encephalitis patients in Poland. Here we present the results of WNV RNA and anti-WNV testing in serum and cerebrospinal fluid (CSF) samples in 80 patients with the clinical diagnosis of viral encephalitis. WNV RNA was not detected in any of the analyzed samples...
2016: Central-European Journal of Immunology
https://www.readbyqxmd.com/read/28450800/assessment-of-interleukin-17a-c5a-and-rantes-for-early-diagnosis-of-neonatal-sepsis-a-preliminary-study
#8
Beata Kasztelewicz, Ewa Piotrowska, Justyna Tołłoczko, Maria K Borszewska-Kornacka, Hanna Gregorek, Katarzyna Dzierżanowska-Fangrat
The aim of the present study was to investigate serum levels of novel markers: interleukin 17A (IL-17A), anaphylatoxin C5a and chemokine regulated upon activation normal T-cell expressed and secreted (RANTES) in neonates with clinically suspected early-onset neonatal sepsis (EONS), and to compare their values with those of non-infected neonates. Eighteen neonates with clinical signs and symptoms of EONS were enrolled in this study. Fifty healthy, non-infected neonates served as the control group. In all neonates serum levels of IL-17A, C5a and RANTES were measured by solid-phase sandwich enzyme-linked immunosorbent assay (ELISA)...
2016: Central-European Journal of Immunology
https://www.readbyqxmd.com/read/28450799/the-effect-of-hydrolysates-of-proteins-from-rice-milk-on-the-physiological-response-of-enterocytes-and-on-the-adhesion-of-bacteria-from-healthy-and-allergic-people-an-in-vitro-study
#9
Dominika Świątecka, Lidia H Markiewicz, Barbara Wróblewska
Designing an optimal diet requires knowledge of the biological activity of food products, particularly in relation to people with food allergies. The hypothesis, which constitutes the basis of this thesis, states that the peptides and glycopeptides released from proteins by enzymatic hydrolysis are able to change the quantity and quality of the human gastrointestinal ecosystem. Such substrates may interfere with adhesion to the intestinal epithelium microbiota and alter enterocytic metabolic activity. The aim of this study was to determine the effect of protein hydrolysates from rice milk substitute on gut epithelial cells and the intestinal microbiota of healthy people and ones suffering from an allergy to milk...
2016: Central-European Journal of Immunology
https://www.readbyqxmd.com/read/28450798/elevated-level-of-some-chemokines-in-plasma-of-gastric-cancer-patients
#10
Monika Baj-Krzyworzeka, Kazimierz Węglarczyk, Jarek Baran, Antoni Szczepanik, Mirosław Szura, Maciej Siedlar
INTRODUCTION: Gastric cancer is one of the most common cancer-related causes of death. This is mainly due to the lack of good noninvasive method/biomarkers suitable for early-tumour diagnosis and planning of further therapy modalities. Chemokines play an important role in cancer progression and metastasis formation. In gastric cancer patients, clinical relevance of CXCL12 and CCL5 level has been postulated. AIM OF THE STUDY: Efforts were undertaken to examine whether expanded chemokine range may be relevant for evaluation of preoperative staging of gastric cancer patients...
2016: Central-European Journal of Immunology
https://www.readbyqxmd.com/read/28450797/egb761-attenuates-depressive-like-behaviours-induced-by-long-term-light-deprivation-in-c57bl-6j-mice-through-inhibition-of-nf-%C3%AE%C2%BAb-il-6-signalling-pathway
#11
Yongdong Zhang, Yuehan Zhao, Fang Pan, Panmin Zhang
Our previous investigation found that Ginkgo extract EGb761 could attenuate the depressive-like behaviours induced by a single injection of lipopolysaccharide in mice. However, it has not been investigated whether EGb761 is effective on depressive-like behaviours induced by long-term light deprivation and whether its effects are associated with the inhibition of NF-κB-IL-6 signalling pathway. In this study, three groups (vehicle group, EGb761 low-dose group, and EGb761 high-dose group) of C57BL/6J male mice were exposed to constant darkness for four weeks...
2016: Central-European Journal of Immunology
https://www.readbyqxmd.com/read/28450796/ellagic-acid-alleviates-adjuvant-induced-arthritis-by-modulation-of-pro-and-anti-inflammatory-cytokines
#12
Gamal Allam, Emad A Mahdi, Abdullah M Alzahrani, Abdelaziz S Abuelsaad
Rheumatoid arthritis (RA) is a chronic inflammatory disease of unknown aetiology, but it is now clear that pro-inflammatory cytokines play a central role in its pathogenesis. Ellagic acid (EA) has a variety of biological activities including anti-oxidant, anti-inflammatory, and anti-cancer properties. The aim of the present study was to evaluate the potential effect of ellagic acid on the prevention and/or treatment of adjuvant induced arthritis (AIA) model in mice. Ellagic acid treatment was started one week before AIA induction and continued for three weeks after induction of AIA...
2016: Central-European Journal of Immunology
https://www.readbyqxmd.com/read/28450795/expression-of-surface-and-intracellular-toll-like-receptors-by-mature-mast-cells
#13
Justyna Agier, Paulina Żelechowska, Elżbieta Kozłowska, Ewa Brzezińska-Błaszczyk
Nowadays, more and more data indicate that mast cells play an important role in host defense against pathogens. That is why it is essential to understand the expression of Toll-like receptors (TLRs) by mast cells, because these molecules play particularly significant role in initiation host defense against microorganisms as they recognize both wide range of microbial pathogen-associated molecular patterns (PAMPs) and various endogenous damage-associated molecular patterns (DAMPs) released in response to infection...
2016: Central-European Journal of Immunology
https://www.readbyqxmd.com/read/27833453/benign-acute-childhood-myositis-complicating-influenza-b-infection-in-a-boy-with-idiopathic-nephrotic-syndrome
#14
Piotr Skrzypczyk, Joanna Przychodzień, Małgorzata Pańczyk-Tomaszewska
INTRODUCTION: Benign acute childhood myositis (BACM) is an acute complication of an infection characterized by calf pain, limitation of lower limb mobility, an increase in serum creatine kinase, and a self-limiting course. No reports of BACM in children with idiopathic nephrotic syndrome (INS) can be found in the literature. CASE REPORT: A 5-year-old boy with steroid-sensitive INS presented with fever, leg pain, and problems with walking. Physical examination showed pharyngeal erythema, preserved movements in all joints, and weakness of leg muscles...
2016: Central-European Journal of Immunology
https://www.readbyqxmd.com/read/27833452/splenocyte-proliferation-and-anaphylaxis-induced-by-bsa-challenge-in-a%C3%A2-d-galactose-induced-aging-mouse-model
#15
Ji-Hun Park, Tae-Saeng Choi
We previously found a cross-reactive autoantibody that bound to bovine serum albumin generated in a D-galactose-induced aging mouse model. Also, we confirmed that other reducing sugars (glucose and fructose) could induce the formation of autoantibody, and only following subcutaneous injection, not oral or intraperitoneal administration. Mice that had never been exposed to bovine serum albumin produced an anti-bovine serum albumin autoantibody following repeated subcutaneous injection of D-galactose (D-gal)...
2016: Central-European Journal of Immunology
https://www.readbyqxmd.com/read/27833451/heat-shock-proteins-hsps-in-the-homeostasis-of-regulatory-t-cells-tregs
#16
REVIEW
Tomasz Koliński, Natalia Marek-Trzonkowska, Piotr Trzonkowski, Janusz Siebert
Heat shock proteins (HSPs) belong to the family of conservative polypeptides with a high homology of the primary structure. The uniqueness of this family lies in their ability to interact with a large number of different proteins and provide protection from cellular and environmental stress factors as molecular chaperones to keep protein homeostasis. While intracellular HSPs play a mainly protective role, extracellular or membrane-bound HSPs mediate immunological functions and immunomodulatory activity. In immune system are subsets of cells including regulatory T cells (Tregs) with suppressive functions...
2016: Central-European Journal of Immunology
https://www.readbyqxmd.com/read/27833450/the-era-of-anti-vascular-endothelial-growth-factor-vegf-drugs-in-ophthalmology-vegf-and-anti-vegf-therapy
#17
REVIEW
Dorota Pożarowska, Piotr Pożarowski
Angiogenesis is a clue process for tissue development and function, both in normal and pathological conditions. This process is regulated by multiple molecular systems. One of the most potent is vascular endothelial growth factor (VEGF) and its receptor (VEGFR) system. Members of this family are involved in new vessel formation in embryogenesis and maturation, as well as in reparative or pathological reactions in later stages. They play a substantial role in regeneration, inflammation, wound healing, as well as in cancer pathology...
2016: Central-European Journal of Immunology
https://www.readbyqxmd.com/read/27833449/the-relationship-between-the-immune-system-and-oral-manifestations-of-inflammatory-bowel-disease-a-review
#18
REVIEW
Miroslav Vasovic, Nevena Gajovic, Denis Brajkovic, Marina Jovanovic, Natasa Zdravkovaic, Tatjana Kanjevac
Inflammatory bowel diseases (IBDs) are chronic, relapsing inflammatory diseases characterized by exacerbations and remissions of the gastrointestinal tract, clinically manifested as Crohn's disease and ulcerative colitis. The etiology of IBDs is considered to be multi factorial, comprising environmental, immune, microbial and genetic factors. Clinical signs may include abdominal pain, frequent bloody diarrheas, mucorrhea, vomiting, fever, fatigue or weight loss. Changes in the oral cavity often precede intestinal symptoms...
2016: Central-European Journal of Immunology
https://www.readbyqxmd.com/read/27833448/a-possible-link-between-the-epstein-barr-virus-infection-and-autoimmune-thyroid-disorders
#19
REVIEW
Anna Dittfeld, Katarzyna Gwizdek, Marek Michalski, Romuald Wojnicz
The Epstein-Barr virus (EBV), also known as human herpesvirus 4, is a member of the Herpesviridae virus family. EBV infection can cause infectious mononucleosis (IM) in the lytic phase of EBV's life cycle. Past EBV infection is associated with lymphomas, and may also result in certain allergic and autoimmune diseases. Although potential mechanisms of autoimmune diseases have not been clearly elucidated, both genetic and environmental factors, such as infectious agents, are considered to be responsible for their development...
2016: Central-European Journal of Immunology
https://www.readbyqxmd.com/read/27833447/immune-recovery-and-the-risk-of-cmv-ebv-reactivation-in-children-post-allogeneic-haematopoietic-stem-cell-transplantation
#20
Małgorzata Janeczko, Monika Mielcarek, Blanka Rybka, Renata Ryczan-Krawczyk, Dorota Noworolska-Sauren, Krzysztof Kałwak
Immune reconstitution was studied prospectively in 86 children who underwent allogeneic haematopoietic stem cell transplantation (HSCT). We analysed the risk of cytomegalovirus (CMV) and Epstein-Barr virus (EBV) reactivation in correlation with the kinetics of immune recovery and in relation to other potential risk factors that may influence the reactivation of these viruses including: diagnosis, type of HSCT, source of stem cells, type of conditioning, or the occurrence of graft-versus-host disease (GvHD)...
2016: Central-European Journal of Immunology
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