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Infectious Diseases

Tanya Strateva, Ivo Sirakov, Svetoslav Dimov, Angelina Trifonova, Encho Savov, Ivan Mitov
No abstract text is available yet for this article.
March 21, 2018: Infectious Diseases
Swati Sharma, Beena Uppal, Vikas Manchanda, Anuj Sud
No abstract text is available yet for this article.
March 19, 2018: Infectious Diseases
Shinichiro Morioka, Mika Ichikawa, Keita Mori, Hanako Kurai
BACKGROUND: Coagulase-negative staphylococci (CoNS) are the most common contaminants of blood cultures, however, we sometimes have difficulties in determining their clinical significance. It is still controversial that there is a significant difference between the contamination group and the true bacteraemia group in the time to positivity (TTP) of blood cultures. We validated the relationship between a TTP and the presence of CoNS bacteraemia in cancer patients by using an objective, non-judgmental definition for CoNS contamination...
March 16, 2018: Infectious Diseases
Bei Jia, Weihua Wu, Rui Huang, Guiyang Wang, Peixin Song, Yang Li, Yong Liu, Yali Xiong, Xiaomin Yan, Yingying Hao, Juan Xia, Zhaoping Zhang, Yuxin Chen, Chao Wu
BACKGROUND: Severe fever with thrombocytopenia syndrome (SFTS) is a life-threatening infectious disease identified in 2009. SFTS is mainly transmitted by contact with ticks or animals; however, sporadic reports suggested that SFTS could be transmitted among humans. OBJECTIVES: We aimed to comprehensively characterize clinical features and disease progression of SFTS acquired by human-to-human transmission. STUDY DESIGN: A retrospective study of 90 SFTS patients was performed in a tertiary hospital of Nanjing, China, from October 2010 to October 2016...
March 15, 2018: Infectious Diseases
Anny Lam, Magnus Rasmussen, Olof Thompson
BACKGROUND/AIM: Streptococci cause approximately 10% of prosthetic joint infections (PJIs). The aim of this study was to identify the characteristics of patients with streptococcal PJIs and to describe the treatment and outcome of streptococcal PJIs in Skåne county between 2011 and 2015. METHODS: Patients with streptococcal PJIs with positive cultures or PCRs on samples from joint aspirate and/or periprosthetic tissue between 2011 and 2015 in Skåne county, were identified and medical records were studied...
March 13, 2018: Infectious Diseases
Mark R Armstrong, Kate L McCarthy, Robert L Horvath
BACKGROUND: Coxiella burnetii endocarditis can be difficult to diagnose leading to delays in treatment. This retrospective case series study was undertaken to understand the epidemiologic trends and clinical features of Q fever endocarditis in Southeast Queensland, Australia. METHODS: Clinical records of patients from a single center with coding diagnosis of C. burnetii, or serology consistent with chronic Q fever, were reviewed from 1999 to 2015. Data from patients with probable or confirmed Q fever endocarditis was abstracted...
March 8, 2018: Infectious Diseases
Nicolas Cortes-Penfield, Nora T Oliver, Andrew Hunter, Maria Rodriguez-Barradas
No abstract text is available yet for this article.
March 6, 2018: Infectious Diseases
Stamatis Karakonstantis, Dimitra Kalemaki
PURPOSE: The practice of obtaining blood culture in febrile urinary tract infections is controversial, considering that blood cultures rarely provide additional useful information compared to urine cultures alone. Furthermore, whether a longer treatment duration is necessary in bacteremic patients is also controversial. Here, we aim to review to relevant studies. MATERIALS AND METHODS: We searched PubMed and Scopus for studies providing information regarding the discordance between urine and blood cultures...
March 6, 2018: Infectious Diseases
Martin Lagging, Rune Wejstål, Ann-Sofi Duberg, Soo Aleman, Ola Weiland, Johan Westin
AIM: Following the approval of two new therapeutic combinations within the European Union in 2017, the former Swedish recommendations for the treatment of hepatitis C virus (HCV) infection from 2016 were deemed in need of updating. MATERIALS AND METHODS: An expert meeting to this end was held in Stockholm, Sweden in October 2017. RESULTS AND CONCLUSIONS: An interferon-free combination of direct-acting antiviral agents is now recommended for all patients with chronic HCV infection, regardless of liver fibrosis stage, in order to limit morbidity and spread of the disease...
March 1, 2018: Infectious Diseases
Kristian Buch, Jacob Bodilsen, Andreas Knudsen, Lykke Larsen, Jannik Helweg-Larsen, Merete Storgaard, Christian Brandt, Lothar Wiese, Christian Østergaard, Henrik Nielsen, Anne-Mette Lebech
BACKGROUND: The ability of cerebrospinal fluid (CSF) lactate to distinguish between acute bacterial meningitis (ABM) and aseptic meningitis/encephalitis (AME) is debated. We assessed the diagnostic value of CSF lactate to discriminate between ABM and AME. METHODS: We included 176 patients from a prospective adult cohort with neuroinfections. In total, 51 ABM and 125 AME patients with clinically and/or microbiologically diagnosed acute meningitis were examined with CSF-lactate and traditional markers for infection...
February 28, 2018: Infectious Diseases
Eunsung You, Sung-Shin Kim, Juyeon Lee, Tae Yang Yu, Jihyun Cho, Jae Hoon Lee
No abstract text is available yet for this article.
February 28, 2018: Infectious Diseases
Stamatis Karakonstantis, Dimitra Kalemaki
BACKGROUND: Staphylococcus aureus bacteriuria (SABU) concomitant to S. aureus bacteremia (SAB) has been associated with deep-seated infections and worse prognosis. However, the relevant studies were small and inconsistent. Here, we aim to provide a review of the relevant literature, and a meta-analysis of these studies. METHODS: We searched PubMed and Scopus for studies comparing patients with SAB and concomitant SABU to patients with SAB without SABU. RESULTS: Nine relevant studies were identified, involving 1429 patients with SAB, of whom 18...
February 28, 2018: Infectious Diseases
Kerasia-Maria Plachouri, Despoina Gkentzi, Kalliopi Konstantinopoulou, Sofia Leventelli, Georgia Kiriakou, Gabriel Dimitriou, Sofia Georgiou
No abstract text is available yet for this article.
February 27, 2018: Infectious Diseases
Giovanni Bruno, Luciano Colangelo, Danilo Badiali, Salvatore Minisola, Enrico Stefano Corazziari, Walter Gianni
No abstract text is available yet for this article.
February 20, 2018: Infectious Diseases
Fabio Bottari, Sara Boveri, Anna Daniela Iacobone, Chiara Gulmini, Sarah Igidbashian, Maria Cristina Cassatella, Fabio Landoni, Maria Teresa Sandri
BACKGROUND: High-risk (HR) Human Papilloma Virus (HPV) Tests for HPV detection differ in sensitivity and specificity. In this study, we evaluated the sensitivity and specificity of the HC2 HR HPV Test and the Cobas 4800 HPV Test in consecutive cervical samples collected from a referral population with a high prevalence of disease, using CIN2+ histology as clinical outcome. METHODS: Ten thousand two-hundred and thirteen consecutive cervical samples were assayed for HR-HPV in the Laboratory Medicine Division of IEO: 5140 from January 2012 to June 2013 with HC2 and 5073 from July 2013 to December 2014 with the Cobas HPV Test...
February 20, 2018: Infectious Diseases
Meng-Lan Wang, Juan Liao, Bing Wei, Dong-Mei Zhang, Ming He, Ming-Chuan Tao, En-Qiang Chen, Hong Tang
AIM: Recent studies revealed that both quantitative hepatitis B surface antigen (qHBsAg) and hepatitis B core-related antigen (qHBcrAg) could serve as a good marker for predicting treatment response and indirectly reflecting intrahepatic cccDNA levels. This study aimed to compare the value of qHBsAg and qHBcrAg in predicting HBeAg seroconversion among patients undergoing PEG-IFN therapy. METHODS: A total of 31 HBeAg-positive patients, who underwent PEG-IFN therapy for 12 months and follow-up for six months were retrospectively included in this study...
February 20, 2018: Infectious Diseases
Florence Pasquier, Sabine Khalife-Hachem, Jean-Baptiste Micol
No abstract text is available yet for this article.
February 19, 2018: Infectious Diseases
Lenaïg Le Clech, Jean-Philippe Talarmin, Marie-Anne Couturier, Jean-Christophe Ianotto, Christophe Nicol, Ronan Le Calloch, Stéphanie Dos Santos, Pascal Hutin, Didier Tandé, Virginie Cogulet, Christian Berthou, Gaëlle Guillerm
INTRODUCTION: Immediate empirical antibiotic therapy is mandatory in febrile chemotherapy-induced neutropenia, but its optimal duration is unclear, especially in patients with fever of unknown origin (FUO). OBJECTIVES: The primary objective of this 20-month prospective observational study was to evaluate the feasibility and safety of short-term antibiotic treatment in afebrile or febrile patients exhibiting FUO, irrespective of their neutrophil count. The secondary objective was to describe the epidemiology of all episodes of febrile neutropenia...
February 16, 2018: Infectious Diseases
Yan Song, Li Zhang, Hao Yang, Guangjun Liu, Hongfeng Huang, Jianyong Wu, Jianghua Chen
BACKGROUND: Nontuberculous mycobacterium (NTM) infections are important complications in renal transplant recipients. METHODS: Cases of NTM diseases post-renal transplantation published in English were identified in the PubMed database. The clinical and laboratory characteristics of these cases were reviewed. RESULTS: One-hundred and fifteen cases of NTM infection in renal transplant recipients in 100 articles were identified. The median time of NTM infection from renal transplantation was 37 months (range, 3 d to 252 months)...
February 5, 2018: Infectious Diseases
Hadir A ElMahallawy, Mai M Zafer, Magdy A Amin, Mai M Ragab, Mohamed H Al-Agamy
No abstract text is available yet for this article.
January 26, 2018: Infectious Diseases
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