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Infectious Diseases

Corinne Ruppen, Laurent Decosterd, Parham Sendi
BACKGROUND: According to expert opinions, gentamicin should be administered as an adjunct to penicillin against severe group B streptococcal (GBS) infections. Whether the adjunct is important is of particular interest for elderly patients. Not only is the risk of aminoglycoside nephrotoxicity higher in elderly persons, but their immune defence to bacterial infections may also be impaired. METHOD: Time-kill assays with human blood products, such as serum, neutrophilic granulocytes (opsonophagocytic assays) and whole blood from healthy, elderly volunteers were performed to evaluate the effect of gentamicin in combination with penicillin...
October 21, 2016: Infectious Diseases
Yusuke Yoshino, Kazunori Seo, Ichiro Koga, Takatoshi Kitazawa, Yasuo Ota
No abstract text is available yet for this article.
October 21, 2016: Infectious Diseases
Eeva-Liisa Paattiniemi, Santra Karumaa, Anna-Mari Viita, Pauliina Kärpänoja, Marjukka Mäkelä, Jaana Isojärvi, Hannu Sarkkinen
Urine culture samples comprise a large proportion of the workload in clinical microbiology laboratories, and most of the urine samples show no growth or insignificant growth. A flow cytometry-based analyzer (Sysmex Corporation, Japan) has been used to screen out negative urine samples prior to culture in the Päijät-Häme district. We applied decision analytic modelling to analyze, from a laboratory perspective, the economic feasibility of the screening method as compared to culture only (conventional method) for diagnosis of urinary tract infection...
October 21, 2016: Infectious Diseases
Viboon Boonsarngsuk, Siriwan Saengsri, Pitak Santanirand
BACKGROUND: Intrathoracic tuberculous (TB) lymphadenitis is a diagnostic challenge to the clinician. Although endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) can obtain a sample from the affected lymph node, the diagnosis of TB lymphadenitis by cytopathology remains inaccurate. OBJECTIVE: To evaluate the efficacy of EBUS-TBNA rinse fluid TB polymerase chain reaction (PCR) assay for the diagnosis of intrathoracic TB lymphadenitis. METHODS: A retrospective study was conducted on 102 patients who underwent EBUS-TBNA for diagnostic evaluation of intrathoracic lymphadenopathy...
October 21, 2016: Infectious Diseases
Jie Yang, Jiawen Zhang, Qundi Deng, Junping Wang, Yunbin Chen, Xiaohong Liu, Fei Wu, Jianmin Niu, Xiaoping Mu
No abstract text is available yet for this article.
October 13, 2016: Infectious Diseases
Jagdish Chander, Nidhi Singla, Mandeep Kaur, Rajpal Singh Punia, Ashok Attri, Ana Alastruey-Izquierdo, José F Cano-Lira, Alberto Miguel Stchigel, Josep Guarro
BACKGROUND: Saksenaea erythrospora is an emerging and recently described pathogenic fungus mainly causing invasive cutaneous infections. Globally, very few human cases, caused by S. erythrospora, have been reported. In India, among the genus Saksenaea, S. vasiformis was the only reported pathogenic species, until recently when a case of fungal rhinosinusitis was reported to be caused by S. erythrospora. We observed five human cases of necrotizing skin and soft tissue infections caused by S...
October 4, 2016: Infectious Diseases
Disa Dahlman, Jonas Berge, Anna C Nilsson, Alex H Kral, Per Bjorkman, Anders C Hakansson
BACKGROUND: While methicillin-resistant Staphylococcus aureus (MRSA) is increasing in prevalence globally, Sweden is still a low-prevalence country enabling studies on the natural MRSA spread in subpopulations unaffected by a surrounding highly infected population. Substance dependence and injection drug use have been risk factors for MRSA carriage and infection in other countries. In this retrospective, longitudinal register study, we investigated MRSA epidemiology 1997-2013 in opioid and amphetamine-dependent individuals, in comparison with alcohol-dependent subjects...
October 4, 2016: Infectious Diseases
Xiao-Fang Wang, Wen-Fang Dong, Ting Dai
No abstract text is available yet for this article.
September 29, 2016: Infectious Diseases
Emad Abu Sitta, Eyassu Habte-Gabr, Zaid Qaraghan, Nour Aljariri Alhesan, Carlos Rios-Bedoya
No abstract text is available yet for this article.
September 29, 2016: Infectious Diseases
Carlos Fritzsche, Hosam Ghanem, Sebastian Koball, Brigitte Mueller-Hilke, Emil C Reisinger
Haemodialysis patients have been found to have an increased risk of developing Pneumocystis pneumonia (PcP) compared to the control population. To the best of our knowledge, no data are available on pulmonary colonization with Pneumocystis jirovecii in haemodialysis patients; therefore, the aim of this study was to determine the prevalence of pulmonary colonization with P. jirovecii in haemodialysis patients, and to find the related risk factors. Induced sputa of 62 haemodialysis patients were investigated using quantitative polymerase chain reaction for the presence of P...
September 29, 2016: Infectious Diseases
Chris Kosmidis, Pippa Newton, Eavan G Muldoon, David W Denning
BACKGROUND: Chronic pulmonary aspergillosis (CPA) has substantial impact on quality of life. A subset of patients develops significant pulmonary fibrosis, identified either on biopsy or radiologically. The term chronic fibrosing pulmonary aspergillosis (CFPA) has been suggested. METHODS: We describe 11 patients with CFPA referred to our centre. RESULTS: Mean age was 58.5 years and five were male. In nine, fibrosis was already evident on presentation, while in two it developed 3 and 6 years later...
September 23, 2016: Infectious Diseases
Thanda Tun, Khin Saw Aye, Wint Wint Nyunt, John A Crump, Chie Nakajima, Yasuhiko Suzuki, Kyi Kyi Thinn, Gregory M Cook, Htin Lin Aung
No abstract text is available yet for this article.
September 19, 2016: Infectious Diseases
Michala Kehrer, Jesper Hallas, Jesper Bælum, Thøger Gorm Jensen, Court Pedersen, Annmarie Touborg Lassen
BACKGROUND: As little is known about the ability to work in patients with infectious spondylodiscitis, we compared the relation between the workforce before infection with that of a reference population and described the patients' ability to work after infection including predictors of return to work (RTW). METHODS: We identified all patients aged 20-57 years treated for infectious spondylodiscitis January 1994-May 2009 at hospitals in Funen County, Denmark. The work status of each week from 2 years before until 2 years after index date was compared with that of a reference population...
September 16, 2016: Infectious Diseases
Urshila Durani, Maria V Dioverti Prono, Pritish K Tosh, Mrinal Patnaik, Jason N Barreto, Aaron J Tande
While lymphopenia is a well-defined risk factor for severe influenza, the effect of neutropenia is unknown. This was a retrospective single centre study of adult patients with documented neutropenia and influenza between 2005 and 2013. Forty patients were included with a median follow-up of 2 years (IQR 0.8-4.0). Median ANC at influenza diagnosis was 0.3 × 10(9)/L (IQR 0.1-0.4 × 10(9)/L). Outcomes included hospitalization (N = 28, 70%), pneumonia (N = 9, 23%), ICU admission (N = 9, 23%) and mechanical ventilation (N = 7, 18%)...
September 16, 2016: Infectious Diseases
Anne-Marie E Sirany, Mary R Kwaan
No abstract text is available yet for this article.
September 13, 2016: Infectious Diseases
Andreas Jonsson, Najia Azhar, Claes Hjalmarsson
BACKGROUND: Surgical site infection (SSI) represents almost 40% of nosocomial infections. Risk for SSI is most prominent following colorectal surgery. There is no Swedish standard SSI classification or surveillance. We have failed to find validation of SSI surveillance programs presently in use. This study investigates SSI registration routines at Halmstad County Hospital, Sweden (HCH) as well as Swedish surgery departments' SSI classification and reporting practices. METHODS: We requested information regarding SSI surveillance routines from all surgical departments performing colorectal surgery in Sweden...
September 13, 2016: Infectious Diseases
Natasha Ghosh, Farida A Malik, Roshni G Daver, Jakapat Vanichanan, Pablo C Okhuysen
BACKGROUND: Viral associated diarrhea (VAD) due to Norovirus (NV), Rotavirus (RV) and Adenovirus (AV) is common in immunocompromised and cancer patients. We sought to determine if the clinical characteristics, morbidity and seasonality of infection differed according to the type of enteric virus identified. METHODS: Cases of NV, RV and AV were identified in stool specimens submitted to the clinical microbiology laboratory between November 2005 and February 2015...
September 13, 2016: Infectious Diseases
Maud Pichon, Nidaa Mikail, Khadija Ben Ali, François Rouzet, Charles Burdet, Yazdan Yazdanpanah, Veronique Joly, Laurent Lepage, Laure Sarda-Mantel
No abstract text is available yet for this article.
September 12, 2016: Infectious Diseases
(no author information available yet)
No abstract text is available yet for this article.
September 2, 2016: Infectious Diseases
Fernando Cobo, Javier Rodríguez-Granger, Enrique M López, Gemma Jiménez, Antonio Sampedro, Luis Aliaga-Martínez, José María Navarro-Marí
BACKGROUND: The clinical and microbiological characteristics of prosthetic joint infection (PJI) caused by Candida species is described, including 72 cases in the literature and a case of Candida glabrata infection handled at the present centre. METHODS: We describe one patient and using the key words 'fungal prosthetic joint infection' and 'candida prosthetic joint infection' we searched MEDLINE (National Library of Medicine, Bethesda, MD), Web of Science, CINAHL and Cochrane systematic review databases for case reports of this condition...
September 1, 2016: Infectious Diseases
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