journal
MENU ▼
Read by QxMD icon Read
search

Frontiers in Medicine

journal
https://www.readbyqxmd.com/read/30238006/classification-and-outcome-measures-for-psoriatic-arthritis
#1
REVIEW
Ying Ying Leung, Alexis Ogdie, Ana-Maria Orbai, William Tillett, Laura C Coates, Vibeke Strand, Philip Mease, Dafna D Gladman
Psoriatic arthritis (PsA) is an inflammatory arthritis with multiple manifestations: peripheral/axial arthritis, enthesitis, dactylitis, psoriasis, and nail involvement. From having an agreed upon classification criteria in 2006, the assessment of PsA has advanced from uncertainties to development and validation of numerous specific outcome measures. The Group for Research and Assessment of Psoriasis and Psoriatic arthritis (GRAPPA) has spearheaded the development of a core domain set and is now working on a core outcome measurement set to standardize outcome measures for PsA, that will provide guidance for use of instruments in randomized controlled trials (RCTs) and longitudinal observational studies (LOS)...
2018: Frontiers in Medicine
https://www.readbyqxmd.com/read/30238005/new-insights-into-the-long-non-coding-rna-sra-physiological-functions-and-mechanisms-of-action
#2
REVIEW
Liang Sheng, Lan Ye, Dong Zhang, William P Cawthorn, Bin Xu
Long non-coding RNAs (lncRNA) are emerging as new genetic/epigenetic regulators that can impact almost all physiological functions. Here, we focus on the long non-coding steroid receptor RNA activator (SRA), including new insights into its effects on gene expression, the cell cycle, and differentiation; how these relate to physiology and disease; and the mechanisms underlying these effects. We discuss how SRA acts as an RNA coactivator in nuclear receptor signaling; its effects on steroidogenesis, adipogenesis, and myocyte differentiation; the impact on breast and prostate cancer tumorigenesis; and, finally, its ability to modulate hepatic steatosis through several signaling pathways...
2018: Frontiers in Medicine
https://www.readbyqxmd.com/read/30238004/eupati-guidance-for-patient-involvement-in-medicines-research-and-development-health-technology-assessment
#3
Amy Hunter, Karen Facey, Victoria Thomas, David Haerry, Kay Warner, Ingrid Klingmann, Matthew May, Wolf See
The main aim of health technology assessment (HTA) is to inform decision making by health care policy makers. It is a systematic process that evaluates the use of health technologies and generally involves a critical review of international evidence related to clinical effectiveness of the health technology vs. the best standard of care. It can also include an evaluation of cost effectiveness, and social and ethical impacts in the local health care system. The HTA process advises whether or not a health technology should be used, and if so, how it is best used and which patients are most likely to benefit from it...
2018: Frontiers in Medicine
https://www.readbyqxmd.com/read/30234119/an-update-on-breast-cancer-multigene-prognostic-tests-emergent-clinical-biomarkers
#4
REVIEW
André Filipe Vieira, Fernando Schmitt
Multigene signatures generate crucial prognostic information particularly useful for cancer patients where clinical parameters and traditional immunohistochemical markers alone lead to equivocal prognosis. Clinicians are now provided with molecular tools that assist in the outline of adjuvant therapies, namely helping decide on the extension of adjuvant endocrine therapy or on suppressing adjuvant chemotherapy in patients were toxic effects are particularly deleterious or when this treatment is fundamentally not needed...
2018: Frontiers in Medicine
https://www.readbyqxmd.com/read/30234118/remini-sing-a-feasibility-study-of-therapeutic-group-singing-to-support-relationship-quality-and-wellbeing-for-community-dwelling-people-living-with-dementia-and-their-family-caregivers
#5
Jeanette Tamplin, Imogen N Clark, Young-Eun C Lee, Felicity A Baker
Background: Living at home following a diagnosis of dementia can be difficult for both the person living with dementia (PwD) and their family caregivers (FCG). Active group music participation may provide an avenue for emotional release, offer psychosocial support to caregivers and stimulate meaningful interaction between caregivers and loved ones with dementia. Therapeutic music interventions also have the capacity to facilitate reminiscence and social engagement and can help to manage challenging symptoms associated with dementia, such as anxiety, apathy, and agitation...
2018: Frontiers in Medicine
https://www.readbyqxmd.com/read/30234117/editorial-pathogenic-advances-and-therapeutic-perspectives-for-eosinophilic-inflammation
#6
EDITORIAL
Florence E Roufosse, Mats W Johansson
No abstract text is available yet for this article.
2018: Frontiers in Medicine
https://www.readbyqxmd.com/read/30234116/comorbidities-and-treatment-strategies-in-bullous-pemphigoid-an-appraisal-of-the-existing-litterature
#7
REVIEW
Rikke Bech, Line Kibsgaard, Christian Vestergaard
Bullous Pemphigoid is an autoimmune skin blistering disease. It is caused by deposition of auto antibodies along the dermal-epidermal border leading to inflammation. The antibodies are directed against anchoring filaments in the epidermis, but these antigens are also present in the neurological tissues and this has led to speculation of an association between multiple sclerosis and bullous pemphigoid. Additionally recent epidemiological studies have pointed at an increased risk of cardio-vascualr diseases and an increased moratality among the patients with bullous pemphigoid...
2018: Frontiers in Medicine
https://www.readbyqxmd.com/read/30234115/tumor-heterogeneity-in-primary-colorectal-cancer-and-corresponding-metastases-does-the-apple-fall-far-from-the-tree
#8
REVIEW
Annika Blank, Daniel Edward Roberts, Heather Dawson, Inti Zlobec, Alessandro Lugli
Colorectal cancer harbors tremendous heterogeneity, with temporal and spatial differences in genetic mutations, epigenetic regulation, and tumor microenvironment. Analyzing the distribution and frequency of genetic, epigenetic, and microenvironment differences within a given tumor and between different sites of a metastatic tumor has been used as a powerful tool to investigate tumorigenesis, tumor progression, and to yield insight into various models of tumor development. A better understanding of tumor heterogeneity would have tremendous clinical relevance, which may manifest most clearly when genetic analyses to inform treatment decisions are performed on a very limited sample of a large tumor...
2018: Frontiers in Medicine
https://www.readbyqxmd.com/read/30214901/sun-exposure-and-melanoma-certainties-and-weaknesses-of-the-present-knowledge
#9
Mariachiara Arisi, Cristina Zane, Simone Caravello, Chiara Rovati, Arianna Zanca, Marina Venturini, Piergiacomo Calzavara-Pinton
Sun exposure is the main risk factor for cutaneous malignant melanoma (CMM). However, the UV-related pathogenetic mechanisms leading to CMM are far to be fully elucidated. In this paper we will focus on what we still don't fully know about the relationship between UVR and CMM. In particular, we will discuss: the action spectrum of human CMM, how different modalities of exposure (continuous/ intermittent; erythemal/ suberythemal) relate to different CMM variants, the preferential UVR induced DNA mutations observed in different CMM variants, the role of UV-related and UV-unrelated genetic damages in the same melanoma cells...
2018: Frontiers in Medicine
https://www.readbyqxmd.com/read/30211168/cystic-fibrosis-kidney-disease-10-tips-for-clinicians
#10
Alexandra C H Nowakowski
Increased longevity in people with cystic fibrosis (CF) means that more people are surviving long enough to develop kidney complications. Nephrologists and their colleagues now face a steep learning curve as many of them encounter patients with CF related kidney disease (CFKD) for the first time. This article presents perspectives from a medical sociologist with CF on what renal health professionals should know about people with CFKD. It outlines challenges that people with CFKD as they age, framing these struggles as opportunities for clinicians to help these unique patients achieve and maintain their best possible quality of life...
2018: Frontiers in Medicine
https://www.readbyqxmd.com/read/30211167/fertility-sparing-treatment-in-patients-with-early-stage-endometrial-cancer-using-a-combination-of-surgery-and-gnrh-agonist-a-monocentric-retrospective-study-and-review-of-the-literature
#11
Stéphanie Tock, Pascale Jadoul, Jean-Luc Squifflet, Etienne Marbaix, Jean-François Baurain, Mathieu Luyckx
Objectives: To evaluate the efficacy and safety of gonadotropin-releasing hormone (GnRH) agonist after endometrial resection in women suffering early stage endometrial carcinoma (EC) and/or endometrial intra-epithelial neoplasia (EIN). Design: A retrospective review of clinical files between January 1999 and December 2016. Setting: University hospital. Patients: Eighteen women younger than 41 years with grade 1 endometrial carcinoma (G1EC) and/or Endometrial intra-epithelial neoplasia (EIN). INTERVENTIONS: All patients received GnRH agonist for 3 months after an endometrial resection combined with a laparoscopy to exclude concomitant ovarian tumor and/or other extra-uterine disease...
2018: Frontiers in Medicine
https://www.readbyqxmd.com/read/30211166/on-the-way-to-in-vitro-platelet-production
#12
REVIEW
Catherine Strassel, Christian Gachet, François Lanza
The severely decreased platelet counts (10-30. 103 platelets/μL) frequently observed in patients undergoing chemotherapy, radiation treatment, or organ transplantation are associated with life-threatening increased bleeding risks. To circumvent these risks, platelet transfusion remains the treatment of choice, despite some limitations which include a limited shelf-life, storage-related deterioration, the development of alloantibodies in recipients and the transmission of infectious diseases. A sustained demand has evolved in recent years for controlled blood products, free of infectious, inflammatory, and immune risks...
2018: Frontiers in Medicine
https://www.readbyqxmd.com/read/30211165/ultraviolet-a1-phototherapy-for-fibrosing-conditions
#13
REVIEW
Thilo Gambichler, Lutz Schmitz
In this article we describe efficacy and safety aspects of ultraviolet A1 (UV-A1) phototherapy in fibrosing conditions. UV-A1 is a specific phototherapeutic modality that is defined by a selective spectral range (340-400 nm). UV-A1 includes distinct modes of action qualifying this method for therapy of a variety of conditions, in particular fibrosing skin diseases. Concerning efficacy of UV-A1 phototherapy in fibrosing conditions, the best evidence obtained from randomized controlled trials exists for localized scleroderma...
2018: Frontiers in Medicine
https://www.readbyqxmd.com/read/30211164/extracorporeal-photopheresis-an-overview
#14
REVIEW
Ara Cho, Christian Jantschitsch, Robert Knobler
Extracorporeal photopheresis (ECP) has been in clinical use for over three decades after receiving FDA approval for the palliative treatment of the Sézary Syndrome variant of cutaneous T-cell lymphoma (CTCL) in 1988. After the first positive experiences with CTCL, additional indications have been successfully explored including areas such as graft-vs.-host disease (GVHD), scleroderma, and solid organ transplantation. The mechanism of action is still not fully resolved, but important steps in understanding ECP in recent years have been very informative...
2018: Frontiers in Medicine
https://www.readbyqxmd.com/read/30186836/commercial-scale-manufacturing-of-allogeneic-cell-therapy
#15
REVIEW
Gary M Pigeau, Elizabeth Csaszar, Aaron Dulgar-Tulloch
Allogeneic cell therapy products are generating encouraging clinical and pre-clinical results. Pluripotent stem cell (PSC) derived therapies, in particular, have substantial momentum and the potential to serve as treatments for a wide range of indications. Many of these therapies are also expected to have large market sizes and require cell doses of ≥109 cells. As therapeutic technologies mature, it is essential for the cell manufacturing industry to correspondingly develop to adequately support commercial scale production...
2018: Frontiers in Medicine
https://www.readbyqxmd.com/read/30177969/the-growing-incidence-of-bullous-pemphigoid-overview-and-potential-explanations
#16
REVIEW
Khalaf Kridin, Ralf J Ludwig
Bullous pemphigoid (BP) is the most common type of subepidermal autoimmune bullous diseases. BP characteristically affects the elderly and is seen mainly in patients older than 70 years. While the annual incidence of BP has been estimated to be between 2.4 and 23 cases per million in the general population, it rises exponentially to 190-312 cases per million in individuals older than 80 years. In addition, a growing body of evidence reports a remarkable trend of increased incidence of BP, showing a 1.9- to 4...
2018: Frontiers in Medicine
https://www.readbyqxmd.com/read/30175100/eupati-and-patients-in-medicines-research-and-development-guidance-for-patient-involvement-in-regulatory-processes
#17
David Haerry, Cordula Landgraf, Kay Warner, Amy Hunter, Ingrid Klingmann, Matthew May, Wolf See
The importance and merits of greater patient involvement in medicines research and development (R&D) are commonly acknowledged and is thought to offer benefits for all involved parties. It improves discovery, development, and evaluation of new effective medicines, based, among others, on the collaborative identification and understanding of unmet needs, research priorities, optimization of clinical study design, as well as incorporating patient views in regulatory activities. It fosters increased transparency, trust and mutual respect between patients and other stakeholders and applies to all stages of medicines R&D, inclusive of regulation and licensing of medicines and appraisal by health technology assessment (HTA) bodies...
2018: Frontiers in Medicine
https://www.readbyqxmd.com/read/30175099/von-willebrand-factor-free-hemoglobin-and-thrombosis-in-ecmo
#18
Christian Valladolid, Andrew Yee, Miguel A Cruz
Though extracorporeal membrane oxygenation (ECMO) provides life-saving support, this intervention exposes patients to certain risks. Circulating free hemoglobin (fHb) resulting from mechanically induced hemolysis and insufficient haptoglobin/hemopexin may promote thrombosis within the ECMO circuit. Thrombi in the circuit can result in thromboembolic complications in these patients. Prevention of thrombus formation and propagation in the ECMO circuit may improve clinical outcome. fHb released during hemolysis has been shown to have multiple adverse effects, including thrombosis, but the mechanism by which fHb contributes to thrombosis in an ECMO circuit remains elusive...
2018: Frontiers in Medicine
https://www.readbyqxmd.com/read/30167433/influence-of-genetic-polymorphism-towards-pulmonary-tuberculosis-susceptibility
#19
REVIEW
Murugesan Harishankar, Paramasivam Selvaraj, Ramalingam Bethunaickan
Tuberculosis (TB) is still remains the major threat for human health worldwide. Several case-control, candidate-gene, family studies and genome-wide association studies (GWAS) suggested the association of host genetic factors to TB susceptibility or resistance in various ethnic populations. Moreover, these factors modulate the host immune responses to tuberculosis. Studies have reported genetic markers to predict TB development in human leukocyte antigen (HLA) and non-HLA genes like killer immunoglobulin-like receptor (KIR), toll-like receptors (TLRs), cytokine/chemokines and their receptors, vitamin D receptor (VDR) and SLC11A1 etc...
2018: Frontiers in Medicine
https://www.readbyqxmd.com/read/30159314/understanding-urogenital-schistosomiasis-related-bladder-cancer-an-update
#20
REVIEW
Kenji Ishida, Michael H Hsieh
Infection with Schistosoma haematobium leads to urogenital schistosomiasis, which has been correlated with the occurrence of bladder cancer. However, mechanisms responsible for this association have not yet been clearly identified. In this short review, we provide an update, highlighting the most recent studies on schistosome-associated bladder cancer, including those that focus on identifying changes in host biology during S. haematobium infection, as well as studies for the identification of potentially pro-carcinogenic parasite molecules, and we offer a discussion on some possible mechanisms driving schistosomal bladder cancer...
2018: Frontiers in Medicine
journal
journal
49682
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"