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Frontiers in Medicine

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https://www.readbyqxmd.com/read/28191456/the-short-form-score-for-the-assessment-and-quantification-of-chronic-rheumatic-affections-of-the-hands-in-daily-clinical-routines-its-sensitivity-to-change-and-preliminary-patient-relevant-variation-values-a-pilot-study
#1
Ulrike Stummer, Bernhard Rintelen, Burkhard F Leeb
OBJECTIVE: The SF-SACRAH was developed to assess the involvement of the hand in rheumatoid arthritis (RA) and hand osteoarthritis (HOA) patients in daily clinical routines. In this pilot study, its sensitivity to change will be assessed longitudinally, and preliminary thresholds for patient relevant changes are derived. METHODS: Ninety-nine outpatients suffering from HOA (n = 55) or RA (n = 44) completed the SF-SACRAH once initially. After approximately 3 months, patients repeated the SF-SACRAH...
2017: Frontiers in Medicine
https://www.readbyqxmd.com/read/28191455/ankylosing-spondylitis-patients-have-impaired-osteoclast-gene-expression-in-circulating-osteoclast-precursors
#2
Inês P Perpétuo, Joana Caetano-Lopes, Elsa Vieira-Sousa, Raquel Campanilho-Marques, Cristina Ponte, Helena Canhão, Mari Ainola, João E Fonseca
INTRODUCTION: Ankylosing spondylitis (AS) is typically characterized by focal bone overgrowth and also by systemic bone loss. We hypothesize that the increased osteoproliferation found in AS might be partially due to reduced ability of osteoclast precursors (OCPs) to differentiate into osteoclasts (OCs). Therefore, our aim was to characterize bone remodeling and pro-osteoclastogenesis inflammatory environment, monocytes' phenotype, and in vitro osteoclast differentiation in AS patients...
2017: Frontiers in Medicine
https://www.readbyqxmd.com/read/28168189/historical-evolution-of-second-line-therapy-in-non-small-cell-lung-cancer
#3
REVIEW
Chiara Lazzari, Alessandra Bulotta, Monika Ducceschi, Maria Grazia Viganò, Elena Brioschi, Francesca Corti, Luca Gianni, Vanesa Gregorc
Innovative therapeutic agents have significantly improved outcome with an acceptable safety profile in a substantial proportion of non-small cell lung cancer (NSCLC) patients, who depend on oncogenic molecular alterations for their malignant phenotype. Despite the survival improvement achieved with first-line chemotherapy, about 30% of patients do not obtain a tumor response. Moreover, those patients, initially sensitive to treatment, acquire resistance and develop tumor progression after a median of about 5 months...
2017: Frontiers in Medicine
https://www.readbyqxmd.com/read/28164085/public-private-partnerships-in-cloud-computing-services-in-the-context-of-genomic-research
#4
REVIEW
Palmira Granados Moreno, Yann Joly, Bartha Maria Knoppers
Public-private partnerships (PPPs) have been increasingly used to spur and facilitate innovation in a number of fields. In healthcare, the purpose of using a PPP is commonly to develop and/or provide vaccines and drugs against communicable diseases, mainly in developing or underdeveloped countries. With the advancement of technology and of the area of genomics, these partnerships also focus on large-scale genomic research projects that aim to advance the understanding of diseases that have a genetic component and to develop personalized treatments...
2017: Frontiers in Medicine
https://www.readbyqxmd.com/read/28164084/comparison-of-phenylephrine-and-ephedrine-in-treatment-of-spinal-induced-hypotension-in-high-risk-pregnancies-a-narrative-review
#5
REVIEW
Sasima Dusitkasem, Blair H Herndon, Monsicha Somjit, David L Stahl, Emily Bitticker, John C Coffman
PURPOSE: To compare maternal and fetal effects of intravenous phenylephrine and ephedrine administration during spinal anesthesia for cesarean delivery in high-risk pregnancies. SOURCE: An extensive literature search was conducted using the US National Library of Medicine, MEDLINE search engine, Cochrane review, and Google Scholar using search terms "ephedrine and phenylephrine," "preterm and term and spinal hypotension," "preeclampsia and healthy parturients," or "multiple and singleton gestation and vasopressor...
2017: Frontiers in Medicine
https://www.readbyqxmd.com/read/28149838/anti-il17a-in-axial-spondyloarthritis-where-are-we-at
#6
Peter P Cheung
Knowledge regarding the mechanisms of the IL17-IL23 pathway and its role in spondyloarthritis (SpA) has been pivotal to the development of IL-17 blockade in patients with axial SpA. Previously, only anti-TNF has proven to be clinically efficacious in patients with active disease, despite non-steroidal anti-inflammatory drugs and physiotherapy. However, up to 50% fail to achieve a clinically significant response. Secukinumab, a fully humanized monoclonal antibody targeting IL-17A, has recently been approved for use in patients with active ankylosing spondylitis...
2017: Frontiers in Medicine
https://www.readbyqxmd.com/read/28154815/the-european-lead-factory-a-blueprint-for-public-private-partnerships-in-early-drug-discovery
#7
REVIEW
Anna Karawajczyk, Kristina M Orrling, Jon S B de Vlieger, Ton Rijnders, Dimitrios Tzalis
The European Lead Factory (ELF) is a public-private partnership (PPP) that provides researchers in Europe with a unique platform for translation of innovative biology and chemistry into high-quality starting points for drug discovery. It combines an exceptional collection of small molecules, high-throughput screening (HTS) infrastructure, and hit follow-up capabilities to advance research projects from both private companies and publicly funded researchers. By active interactions with the wider European life science community, ELF connects and unites bright ideas, talent, and experience from several disciplines...
2016: Frontiers in Medicine
https://www.readbyqxmd.com/read/28149837/next-generation-egfr-tyrosine-kinase-inhibitors-for-treating-egfr-mutant-lung-cancer-beyond-first-line
#8
REVIEW
Ivana Sullivan, David Planchard
Tyrosine kinase inhibitors (TKIs) against the human epidermal growth factor receptor (EGFR) are now standard treatment in the clinic for patients with advanced EGFR mutant non-small-cell lung cancer (NSCLC). First-generation EGFR TKIs, binding competitively and reversibly to the ATP-binding site of the EGFR tyrosine kinase domain, have resulted in a significant improvement in outcome for NSCLC patients with activating EGFR mutations (L858R and Del19). However, after a median duration of response of ~12 months, all patients develop tumor resistance, and in over half of these patients this is due to the emergence of the EGFR T790M resistance mutation...
2016: Frontiers in Medicine
https://www.readbyqxmd.com/read/28123998/editorial-innovative-radiopharmaceuticals-in-oncology-and-neurology
#9
EDITORIAL
Jacques Barbet, Nicolas Arlicot, Marie-Hélène Gaugler, Michel Chérel, Denis Guilloteau, Françoise Kraeber-Bodéré
No abstract text is available yet for this article.
2016: Frontiers in Medicine
https://www.readbyqxmd.com/read/28105410/acellular-dermal-matrix-permacol-%C3%A2-for-heterologous-immediate-breast-reconstruction-after-skin-sparing-mastectomy-in-patients-with-breast-cancer-a-single-institution-experience-and-a-review-of-the-literature
#10
Laura Knabben, Gowthami Kanagalingam, Sara Imboden, Andreas R Günthert
OBJECTIVE: Skin-sparing mastectomy (SSM) with immediate heterologous reconstruction is a safe oncological option in surgical therapy of early breast cancer. Permacol(®) is an acellular dermal matrix (ADM) placed between the implant and the skin to improve lower pole projection and implant coverage. The aim of our study was to evaluate the outcome with a focus on patient satisfaction after 6 months and to analyze physical changes of ADM. METHODS: 10 patients who underwent SSM with Permacol(®) were analyzed retrospectively...
2016: Frontiers in Medicine
https://www.readbyqxmd.com/read/28083535/sundowning-in-dementia-clinical-relevance-pathophysiological-determinants-and-therapeutic-approaches
#11
REVIEW
Marco Canevelli, Martina Valletta, Alessandro Trebbastoni, Giuseppe Sarli, Fabrizia D'Antonio, Leonardo Tariciotti, Carlo de Lena, Giuseppe Bruno
Sundowning means the emergence or worsening of neuropsychiatric symptoms (NPS) in the late afternoon or early evening. This syndrome has been recognized since a long time in the field of dementing illnesses and is well known among most of health-care providers involved in the assistance of people with dementia. Indeed, it represents a common manifestation among persons with dementia and is associated with several adverse outcomes (such as institutionalization, faster cognitive worsening, and greater caregiver burden)...
2016: Frontiers in Medicine
https://www.readbyqxmd.com/read/28083534/the-efficacy-of-triamcinolone-acetonide-in-keloid-treatment-a-systematic-review-and-meta-analysis
#12
Thian-Sze Wong, John Zeng-Hong Li, Siqi Chen, Jimmy Yu-Wai Chan, Wei Gao
Keloid is a cutaneous dermal outgrowth resulting from uncontrolled deposition of collagen and glycosaminoglycan around the wound. The uncontrolled and persistent growth of keloids scar will result in cosmetic disfigurement, functional impairment, and affect the quality of life. Triamcinolone acetonide (TAC) is traditionally employed in treating keloid scars. In this study, we aim to evaluate the effectiveness of TAC and compare it with other common therapy employed in keloid treatment. Only randomized controlled trial (RCT) and controlled trial were included...
2016: Frontiers in Medicine
https://www.readbyqxmd.com/read/28066770/effects-of-constant-flow-vs-constant-pressure-perfusion-on-fluid-filtration-in-severe-hypothermic-isolated-blood-perfused-rat-lungs
#13
Kathrine Halsøy, Timofey Kondratiev, Torkjel Tveita, Lars J Bjertnaes
BACKGROUND: Victims of severe accidental hypothermia are prone to fluid extravasation but rarely develop lung edema. We hypothesize that combined hypothermia-induced increase in pulmonary vascular resistance (PVR) and a concomitant fall in cardiac output protect the lungs against edema development. Our aim was to explore in hypothermic-isolated blood-perfused rat lungs whether perfusion at constant pressure influences fluid filtration differently from perfusion at constant flow. METHODS: Isolated blood-perfused rat lungs were hanging freely in a weight transducer for measuring weight changes (ΔW)...
2016: Frontiers in Medicine
https://www.readbyqxmd.com/read/28066769/liquid-biopsy-in-non-small-cell-lung-cancer
#14
REVIEW
Miguel A Molina-Vila, Clara Mayo-de-Las-Casas, Ana Giménez-Capitán, Núria Jordana-Ariza, Mónica Garzón, Ariadna Balada, Sergi Villatoro, Cristina Teixidó, Beatriz García-Peláez, Cristina Aguado, María José Catalán, Raquel Campos, Ana Pérez-Rosado, Jordi Bertran-Alamillo, Alejandro Martínez-Bueno, María-de-Los-Llanos Gil, María González-Cao, Xavier González, Daniela Morales-Espinosa, Santiago Viteri, Niki Karachaliou, Rafael Rosell
Liquid biopsy analyses are already incorporated in the routine clinical practice in many hospitals and oncology departments worldwide, improving the selection of treatments and monitoring of lung cancer patients. Although they have not yet reached its full potential, liquid biopsy-based tests will soon be as widespread as "standard" biopsies and imaging techniques, offering invaluable diagnostic, prognostic, and predictive information. This review summarizes the techniques available for the isolation and analysis of circulating free DNA and RNA, exosomes, tumor-educated platelets, and circulating tumor cells from the blood of cancer patients, presents the methodological challenges associated with each of these materials, and discusses the clinical applications of liquid biopsy testing in lung cancer...
2016: Frontiers in Medicine
https://www.readbyqxmd.com/read/28066768/focus-on-nintedanib-in-nsclc-and-other-tumors
#15
REVIEW
Anna Manzo, Guido Carillio, Agnese Montanino, Raffaele Costanzo, Claudia Sandomenico, Gaetano Rocco, Alessandro Morabito
Nintedanib is a new triple angiokinase inhibitor that potently blocks the proangiogenic pathways mediated by vascular endothelial growth factor receptors, platelet-derived growth factor receptors, and fibroblast growth factor receptors. Evidence about its efficacy in addition to second-line chemotherapy in non-small cell lung cancer (NSCLC) has been produced by two large randomized phase III clinical trials (LUME-Lung 1 and LUME-Lung 2), conducted in patients with pretreated NSCLC, without major risk factors for bleeding...
2016: Frontiers in Medicine
https://www.readbyqxmd.com/read/28018902/focus-on-nivolumab-in-nsclc
#16
REVIEW
Diego L Cortinovis, Stefania Canova, Marida Abbate, Francesca Colonese, Paolo Bidoli
Immunotherapy is changing the treatment of non-small cell lung cancer (NSCLC). The PD-1 inhibitor nivolumab has demonstrated meaningful results in terms of efficacy with a good safety profile. The novel approach to treating NSCLC using immunotherapy still has unsolved questions and challenging issues. The main doubts regarding the optimal selection of the patient are the role of this drug in first line of treatment, the individualization of the correct methodology of radiologic assessment and efficacy analysis, the best management of immune-mediated adverse events, and how to overcome the immunoresistance...
2016: Frontiers in Medicine
https://www.readbyqxmd.com/read/27999775/protective-ventilation-improves-gas-exchange-reduces-incidence-of-atelectases-and-affects-metabolic-response-in-major-pancreatoduodenal-surgery
#17
Vsevolod V Kuzkov, Ludmila N Rodionova, Yana Y Ilyina, Aleksey A Ushakov, Maria M Sokolova, Eugenia V Fot, Boris L Duberman, Mikhail Y Kirov
BACKGROUND: Protective perioperative ventilation has been shown to improve outcomes and reduce the incidence of postoperative pulmonary complications. The goal of this study was to assess the effects of ventilation with low tidal volume (VT) either alone or in a combination with moderate permissive hypercapnia in major pancreatoduodenal interventions. MATERIALS AND METHODS: Sixty adult patients scheduled for elective pancreatoduodenal surgery with duration >2 h were enrolled into a prospective single-center study...
2016: Frontiers in Medicine
https://www.readbyqxmd.com/read/27965961/focus-on-alectinib-and-competitor-compounds-for-second-line-therapy-in-alk-rearranged-nsclc
#18
REVIEW
Phu N Tran, Samuel J Klempner
The management of anaplastic lymphoma kinase rearranged (ALK+) non-small cell lung cancer (NSCLC) exemplifies the potential of a precision medicine approach to cancer care. The ALK inhibitor crizotinib has led to improved outcomes in the first- and second-line setting; however, toxicities, intracranial activity, and acquired resistance necessitated the advent of later generation ALK inhibitors. A large portion of acquired resistance to ALK inhibitors is caused by secondary mutations in the ALK kinase domain...
2016: Frontiers in Medicine
https://www.readbyqxmd.com/read/27965960/activation-of-coagulation-and-fibrinolysis-in-acute-respiratory-distress-syndrome-a-prospective-pilot-study
#19
Agnese Ozolina, Marina Sarkele, Olegs Sabelnikovs, Andrejs Skesters, Inta Jaunalksne, Jelena Serova, Talis Ievins, Lars J Bjertnaes, Indulis Vanags
INTRODUCTION: Coagulation and fibrinolysis remain sparsely addressed with regards to acute respiratory distress syndrome (ARDS). We hypothesized that ARDS development might be associated with changes in plasma coagulation and fibrinolysis. Our aim was to investigate the relationships between ARDS diagnosis and plasma concentrations of tissue factor (TF), tissue plasminogen activator (t-PA), and plasminogen activator inhibitor-1 (PAI-1) in mechanically ventilated patients at increased risk of developing ARDS...
2016: Frontiers in Medicine
https://www.readbyqxmd.com/read/27965959/a-novel-antithrombotic-mechanism-mediated-by-the-receptors-of-the-kallikrein-kinin-and-renin-angiotensin-systems
#20
REVIEW
Alvin H Schmaier
The contact activation (CAS) and kallikrein/kinin (KKS) systems regulate thrombosis risk in two ways. First, the CAS influences contact activation-induced factor XI activation and thrombin formation through the hemostatic cascade. Second, prekallikrein (PK) and bradykinin of the KKS regulate expression of three vessel wall G-protein-coupled receptors, the bradykinin B2 receptor (B2R), angiotensin receptor 2, and Mas to influence prostacyclin formation. The degree of intravascular prostacyclin formation inversely regulates intravascular thrombosis risk...
2016: Frontiers in Medicine
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