journal
MENU ▼
Read by QxMD icon Read
search

ENeuro

journal
https://www.readbyqxmd.com/read/27896315/altered-oscillatory-dynamics-of-ca1-parvalbumin-basket-cells-during-theta-gamma-rhythmopathies-of-temporal-lobe-epilepsy
#1
Diego Lopez-Pigozzi, François Laurent, Jorge R Brotons-Mas, Mario Valderrama, Manuel Valero, Ivan Fernandez-Lamo, Elena Cid, Daniel Gomez-Dominguez, Beatriz Gal, Liset Menendez de la Prida
Recent reports in human demonstrate a role of theta-gamma coupling in memory for spatial episodes and a lack of coupling in people experiencing temporal lobe epilepsy, but the mechanisms are unknown. Using multisite silicon probe recordings of epileptic rats engaged in episodic-like object recognition tasks, we sought to evaluate the role of theta-gamma coupling in the absence of epileptiform activities. Our data reveal a specific association between theta-gamma (30-60 Hz) coupling at the proximal stratum radiatum of CA1 and spatial memory deficits...
November 2016: ENeuro
https://www.readbyqxmd.com/read/27896314/graph-theoretic-and-motif-analyses-of-the-hippocampal-neuron-type-potential-connectome
#2
Christopher L Rees, Diek W Wheeler, David J Hamilton, Charise M White, Alexander O Komendantov, Giorgio A Ascoli
We computed the potential connectivity map of all known neuron types in the rodent hippocampal formation by supplementing scantly available synaptic data with spatial distributions of axons and dendrites from the open-access knowledge base Hippocampome.org. The network that results from this endeavor, the broadest and most complete for a mammalian cortical region at the neuron-type level to date, contains more than 3200 connections among 122 neuron types across six subregions. Analyses of these data using graph theory metrics unveil the fundamental architectural principles of the hippocampal circuit...
November 2016: ENeuro
https://www.readbyqxmd.com/read/27896313/effects-of-paternal-predation-risk-and-rearing-environment-on-maternal-investment-and-development-of-defensive-responses-in-the-offspring
#3
Austin C Korgan, Elizabeth O'Leary, Jessica Bauer, Aidan Fortier, Ian C G Weaver, Tara S Perrot
Detecting past experiences with predators of a potential mate informs a female about prevailing ecological threats, in addition to stress-induced phenotypes that may be disseminated to offspring. We examined whether prior exposure of a male rat to a predator (cat) odor influences the attraction of a female toward a male, subsequent mother-infant interactions and the development of defensive (emotional) responses in the offspring. Females displayed less interest in males that had experienced predator odor. Mothers that reared young in larger, seminaturalistic housing provided more licking and grooming and active arched back-nursing behavior toward their offspring compared with dams housed in standard housing, although some effects interacted with paternal experience...
November 2016: ENeuro
https://www.readbyqxmd.com/read/27896312/the-memory-trace-supporting-lose-shift-responding-decays-rapidly-after-reward-omission-and-is-distinct-from-other-learning-mechanisms-in-rats
#4
Aaron J Gruber, Rajat Thapa
The propensity of animals to shift choices immediately after unexpectedly poor reinforcement outcomes is a pervasive strategy across species and tasks. We report here that the memory supporting such lose-shift responding in rats rapidly decays during the intertrial interval and persists throughout training and testing on a binary choice task, despite being a suboptimal strategy. Lose-shift responding is not positively correlated with the prevalence and temporal dependence of win-stay responding, and it is inconsistent with predictions of reinforcement learning on the task...
November 2016: ENeuro
https://www.readbyqxmd.com/read/27896311/interfacing-with-neural-activity-via-femtosecond-laser-stimulation-of-drug-encapsulating-liposomal-nanostructures
#5
Takashi Nakano, Sean M Mackay, Eng Wui Tan, Keshav M Dani, Jeff Wickens
External control over rapid and precise release of chemicals in the brain potentially provides a powerful interface with neural activity. Optical manipulation techniques, such as optogenetics and caged compounds, enable remote control of neural activity and behavior with fine spatiotemporal resolution. However, these methods are limited to chemicals that are naturally present in the brain or chemically suitable for caging. Here, we demonstrate the ability to interface with neural functioning via a wide range of neurochemicals released by stimulating loaded liposomal nanostructures with femtosecond lasers...
November 2016: ENeuro
https://www.readbyqxmd.com/read/27844062/memorable-audiovisual-narratives-synchronize-sensory-and-supramodal-neural-responses
#6
Samantha S Cohen, Lucas C Parra
Our brains integrate information across sensory modalities to generate perceptual experiences and form memories. However, it is difficult to determine the conditions under which multisensory stimulation will benefit or hinder the retrieval of everyday experiences. We hypothesized that the determining factor is the reliability of information processing during stimulus presentation, which can be measured through intersubject correlation of stimulus-evoked activity. We therefore presented biographical auditory narratives and visual animations to 72 human subjects visually, auditorily, or combined, while neural activity was recorded using electroencephalography...
November 2016: ENeuro
https://www.readbyqxmd.com/read/27896310/preservation-of-essential-odor-guided-behaviors-and-odor-based-reversal-learning-after-targeting-adult-brain-serotonin-synthesis
#7
Kaitlin S Carlson, Meredith S Whitney, Marie A Gadziola, Evan S Deneris, Daniel W Wesson
The neurotransmitter serotonin (5-HT) is considered a powerful modulator of sensory system organization and function in a wide range of animals. The olfactory system is innervated by midbrain 5-HT neurons into both its primary and secondary odor-processing stages. Facilitated by this circuitry, 5-HT and its receptors modulate olfactory system function, including odor information input to the olfactory bulb. It is unknown, however, whether the olfactory system requires 5-HT for even its most basic behavioral functions...
September 2016: ENeuro
https://www.readbyqxmd.com/read/27844061/lithium-responsive-seizure-like-hyperexcitability-is-caused-by-a-mutation-in-the-drosophila-voltage-gated-sodium-channel-gene-paralytic
#8
Garrett A Kaas, Junko Kasuya, Patrick Lansdon, Atsushi Ueda, Atulya Iyengar, Chun-Fang Wu, Toshihiro Kitamoto
Shudderer (Shu) is an X-linked dominant mutation in Drosophila melanogaster identified more than 40 years ago. A previous study showed that Shu caused spontaneous tremors and defects in reactive climbing behavior, and that these phenotypes were significantly suppressed when mutants were fed food containing lithium, a mood stabilizer used in the treatment of bipolar disorder (Williamson, 1982). This unique observation suggested that the Shu mutation affects genes involved in lithium-responsive neurobiological processes...
September 2016: ENeuro
https://www.readbyqxmd.com/read/27844060/serotonergic-suppression-of-mouse-prefrontal-circuits-implicated-in-task-attention
#9
Michael K Tian, Eric F Schmidt, Evelyn K Lambe
Serotonin (5-HT) regulates attention by neurobiological mechanisms that are not well understood. Layer 6 (L6) pyramidal neurons of prefrontal cortex play an important role in attention and express 5-HT receptors, but the serotonergic modulation of this layer and its excitatory output is not known. Here, we performed whole-cell recordings and pharmacological manipulations in acute brain slices from wild-type and transgenic mice expressing either eGFP or eGFP-channelrhodopsin in prefrontal L6 pyramidal neurons...
September 2016: ENeuro
https://www.readbyqxmd.com/read/27844059/developmental-ethanol-exposure-leads-to-long-term-deficits-in-attention-and-its-underlying-prefrontal-circuitry
#10
Emma L Louth, Warren Bignell, Christine L Taylor, Craig D C Bailey
Chronic prenatal exposure to ethanol can lead to a spectrum of teratogenic outcomes that are classified in humans as fetal alcohol spectrum disorders (FASD). One of the most prevalent and persistent neurocognitive components of FASD is attention deficits, and it is now thought that these attention deficits differ from traditional attention deficit hyperactivity disorder (ADHD) in their quality and response to medication. However, the neuronal mechanisms underlying attention deficits in FASD are not well understood...
September 2016: ENeuro
https://www.readbyqxmd.com/read/27844058/western-high-fat-diet-consumption-during-adolescence-increases-susceptibility-to-traumatic-stress-while-selectively-disrupting-hippocampal-and-ventricular-volumes
#11
Priya Kalyan-Masih, Julio David Vega-Torres, Christina Miles, Elizabeth Haddad, Sabrina Rainsbury, Mohsen Baghchechi, Andre Obenaus, Johnny D Figueroa
Psychological trauma and obesity co-occur frequently and have been identified as major risk factors for psychiatric disorders. Surprisingly, preclinical studies examining how obesity disrupts the ability of the brain to cope with psychological trauma are lacking. The objective of this study was to determine whether an obesogenic Western-like high-fat diet (WD) predisposes rats to post-traumatic stress responsivity. Adolescent Lewis rats (postnatal day 28) were fed ad libitum for 8 weeks with either the experimental WD diet (41...
September 2016: ENeuro
https://www.readbyqxmd.com/read/27844057/combined-treatment-with-environmental-enrichment-and-epigallocatechin-3-gallate-ameliorates-learning-deficits-and-hippocampal-alterations-in-a-mouse-model-of-down-syndrome
#12
Silvina Catuara-Solarz, Jose Espinosa-Carrasco, Ionas Erb, Klaus Langohr, Juan Ramon Gonzalez, Cedric Notredame, Mara Dierssen
Intellectual disability in Down syndrome (DS) is accompanied by altered neuro-architecture, deficient synaptic plasticity, and excitation-inhibition imbalance in critical brain regions for learning and memory. Recently, we have demonstrated beneficial effects of a combined treatment with green tea extract containing (-)-epigallocatechin-3-gallate (EGCG) and cognitive stimulation in young adult DS individuals. Although we could reproduce the cognitive-enhancing effects in mouse models, the underlying mechanisms of these beneficial effects are unknown...
September 2016: ENeuro
https://www.readbyqxmd.com/read/27844056/hyperpolarization-activated-currents-and-subthreshold-resonance-in-granule-cells-of-the-olfactory-bulb
#13
Ruilong Hu, Katie A Ferguson, Christina B Whiteus, Dimphna H Meijer, Ricardo C Araneda
An important contribution to neural circuit oscillatory dynamics is the ongoing activation and inactivation of hyperpolarization-activated currents (Ih). Network synchrony dynamics play an important role in the initial processing of odor signals by the main olfactory bulb (MOB) and accessory olfactory bulb (AOB). In the mouse olfactory bulb, we show that Ih is present in granule cells (GCs), the most prominent inhibitory neuron in the olfactory bulb, and that Ih underlies subthreshold resonance in GCs. In accord with the properties of Ih, the currents exhibited sensitivity to changes in extracellular K(+) concentration and ZD7288 (4-ethylphenylamino-1,2-dimethyl-6-methylaminopyrimidin chloride), a blocker of Ih...
September 2016: ENeuro
https://www.readbyqxmd.com/read/27844055/a-bayesian-account-of-visual-vestibular-interactions-in-the-rod-and-frame-task
#14
Bart B G T Alberts, Anouk J de Brouwer, Luc P J Selen, W Pieter Medendorp
Panoramic visual cues, as generated by the objects in the environment, provide the brain with important information about gravity direction. To derive an optimal, i.e., Bayesian, estimate of gravity direction, the brain must combine panoramic information with gravity information detected by the vestibular system. Here, we examined the individual sensory contributions to this estimate psychometrically. We asked human subjects to judge the orientation (clockwise or counterclockwise relative to gravity) of a briefly flashed luminous rod, presented within an oriented square frame (rod-in-frame)...
September 2016: ENeuro
https://www.readbyqxmd.com/read/27844054/subsecond-sensory-modulation-of-serotonin-levels-in-a-primary-sensory-area-and-its-relation-to-ongoing-communication-behavior-in-a-weakly-electric-fish
#15
Haleh Fotowat, Erik Harvey-Girard, Joseph F Cheer, Rüdiger Krahe, Leonard Maler
Serotonergic neurons of the raphe nuclei of vertebrates project to most regions of the brain and are known to significantly affect sensory processing. The subsecond dynamics of sensory modulation of serotonin levels and its relation to behavior, however, remain unknown. We used fast-scan cyclic voltammetry to measure serotonin release in the electrosensory system of weakly electric fish, Apteronotus leptorhynchus. These fish use an electric organ to generate a quasi-sinusoidal electric field for communicating with conspecifics...
September 2016: ENeuro
https://www.readbyqxmd.com/read/27844053/involvement-of-crfr1-in-the-basolateral-amygdala-in-the-immediate-fear-extinction-deficit
#16
Fiona Hollis, Yannick Sevelinges, Jocelyn Grosse, Olivia Zanoletti, Carmen Sandi
Several animal and clinical studies have highlighted the ineffectiveness of fear extinction sessions delivered shortly after trauma exposure. This phenomenon, termed the immediate extinction deficit, refers to situations in which extinction programs applied shortly after fear conditioning may result in the reduction of fear behaviors (in rodents, frequently measured as freezing responses to the conditioned cue) during extinction training, but failure to consolidate this reduction in the long term. The molecular mechanisms driving this immediate extinction resistance remain unclear...
September 2016: ENeuro
https://www.readbyqxmd.com/read/27844052/neuropilin-1-and-the-positions-of-glomeruli-in-the-mouse-olfactory-bulb
#17
Bolek Zapiec, Olaf Christian Bressel, Mona Khan, Andreas Walz, Peter Mombaerts
It is known since 1996 that mouse odorant receptors (ORs) are involved in determining the positions of the sites of coalescence of axons of olfactory sensory neurons (OSNs)-the thousands of glomeruli in the olfactory bulb. But the molecular and cellular mechanisms of OR-mediated axonal coalescence into glomeruli remain unclear. A model was proposed in 2006-2009 whereby OR-derived cAMP signals, rather than direct action of OR molecules, determine the target destinations (glomeruli) of OSNs in the bulb. This model hypothesizes that OR-derived cAMP signals determine the expression levels of neuropilin 1 (Nrp1) in OSN axon termini; that levels of Nrp1 in glomeruli form a gradient from anterior-low to posterior-high throughout the bulb; and that these Nrp1 levels mechanistically determine anterior-posterior patterning of glomeruli...
September 2016: ENeuro
https://www.readbyqxmd.com/read/27822508/clozapine-n-oxide-administration-produces-behavioral-effects-in-long-evans-rats-implications-for-designing-dreadd-experiments
#18
Duncan A A MacLaren, Richard W Browne, Jessica K Shaw, Sandhya Krishnan Radhakrishnan, Prachi Khare, Rodrigo A España, Stewart D Clark
Clozapine N-oxide (CNO) is a ligand for a powerful chemogenetic system that can selectively inhibit or activate neurons; the so-called Designer Receptors Exclusively Activated by Designer Drugs (DREADD) system. This system consists of synthetic G-protein-coupled receptors, which are not believed to be activated by any endogenous ligand, but are activated by the otherwise inert CNO. However, it has previously been shown that the administration of CNO in humans and rats leads to detectable levels of the bioactive compounds clozapine and N-desmethylclozapine (N-Des)...
September 2016: ENeuro
https://www.readbyqxmd.com/read/27822507/traumatic-brain-injury-stimulates-neural-stem-cell-proliferation-via-mammalian-target-of-rapamycin-signaling-pathway-activation
#19
Xiaoting Wang, Pich Seekaew, Xiang Gao, Jinhui Chen
Neural stem cells in the adult brain possess the ability to remain quiescent until needed in tissue homeostasis or repair. It was previously shown that traumatic brain injury (TBI) stimulated neural stem cell (NSC) proliferation in the adult hippocampus, indicating an innate repair mechanism, but it is unknown how TBI promotes NSC proliferation. In the present study, we observed dramatic activation of mammalian target of rapamycin complex 1 (mTORC1) in the hippocampus of mice with TBI from controlled cortical impact (CCI)...
September 2016: ENeuro
https://www.readbyqxmd.com/read/27822506/striatal-activity-and-reward-relativity-neural-signals-encoding-dynamic-outcome-valuation
#20
Emily S Webber, David E Mankin, Howard C Cromwell
The striatum is a key brain region involved in reward processing. Striatal activity has been linked to encoding reward magnitude and integrating diverse reward outcome information. Recent work has supported the involvement of striatum in the valuation of outcomes. The present work extends this idea by examining striatal activity during dynamic shifts in value that include different levels and directions of magnitude disparity. A novel task was used to produce diverse relative reward effects on a chain of instrumental action...
September 2016: ENeuro
journal
journal
49667
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"