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EBioMedicine

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https://www.readbyqxmd.com/read/28532740/reduced-intellectual-ability-in-offspring-of-ovarian-hyperstimulation-syndrome-a-cohort-study
#1
Gu-Feng Xu, Cheng-Liang Zhou, Yi-Meng Xiong, Jing-Yi Li, Tian-Tian Yu, Shen Tian, Xian-Hua Lin, Yun Liao, Yuan Lv, Fang-Hong Zhang, Zhi-Wei Liu, Yin-Yin Shi, Yan Shen, Jin Sha, Dan Zhang, Yi-Min Zhu, Jian-Zhong Sheng, He-Feng Huang
BACKGROUND: Ovarian hyperstimulation syndrome (OHSS), a complication of ovarian stimulation, has various adverse effects on both pregnant women and their offspring. However, whether OHSS will affect intellectual ability in offspring is still unknown. METHODS: We recruited 86 Chinese children born to OHSS women and 172 children conceived with non-OHSS In Vitro Fertilization (IVF) in this cohort study. Their intellectual ability was assessed according to the Revised Chinese Version of the Wechsler Intelligence Scale for Children (C-WISC)...
May 18, 2017: EBioMedicine
https://www.readbyqxmd.com/read/28529034/dendritic-tau-telidge
#2
Benjamin Wolozin, Ioannis Sotiropoulos
No abstract text is available yet for this article.
May 17, 2017: EBioMedicine
https://www.readbyqxmd.com/read/28529031/clocks-and-cholesterol-co-agonists-in-cardiovascular-disease
#3
Baharan Fekry, Kristin Eckel-Mahan
No abstract text is available yet for this article.
May 17, 2017: EBioMedicine
https://www.readbyqxmd.com/read/28527830/crispr-cas9-mediated-precise-targeted-integration-in-vivo-using-a-double-cut-donor-with-short-homology-arms
#4
Xuan Yao, Xing Wang, Junlai Liu, Xinde Hu, Linyu Shi, Xiaowen Shen, Wenqin Ying, Xinyao Sun, Xin Wang, Pengyu Huang, Hui Yang
Precisely targeted genome editing is highly desired for clinical applications. However, the widely used homology-directed repair (HDR)-based genome editing strategies remain inefficient for certain in vivo applications. We here demonstrate a microhomology-mediated end-joining (MMEJ)-based strategy for precisely targeted gene integration in transfected neurons and hepatocytes in vivo with efficiencies up to 20%, much higher (up to 10 fold) than HDR-based strategy in adult mouse tissues. As a proof of concept of its therapeutic potential, we demonstrate the efficacy of MMEJ-based strategy in correction of Fah mutation and rescue of Fah(-/-) liver failure mice, offering an efficient approach for precisely targeted gene therapies...
May 11, 2017: EBioMedicine
https://www.readbyqxmd.com/read/28529032/synergistic-cytotoxicity-of-lenalidomide-and-dexamethasone-in-mantle-cell-lymphoma-via-cereblon-dependent-targeting-of-the-il-6-stat3-pi3k-axis
#5
Jiexian Ma, Kefei Wu, Weiya Bai, Xiaoxian Cui, Yan Chen, Youhua Xie, Yanhui Xie
At our center, relapsed mantle cell lymphoma (MCL) can be treated with maintenance therapy composed of consecutive low-dose lenalidomide and short-term, high-dose dexamethasone (LD regimen), which achieves good responses (longer overall survival and progression-free survival) and low toxicity. Cereblon is probably targeted by both lenalidomide and dexamethasone, which leads to synergistic cytotoxicity in MCL by inhibiting the interleukin-6/signal transducer and activator of transcription 3 (IL-6/STAT3), phosphatidylinositol 3-kinase (PI3K)/AKT and AKT2/Forkhead box O3 (FOXO3A)/BCL2-like 11 (BIM) pathways...
May 10, 2017: EBioMedicine
https://www.readbyqxmd.com/read/28499925/does-kr%C3%A3-ppel-like-factor-15-play-an-important-role-in-the-left-ventricular-hypertrophy-of-patients-with-type-2-diabetes
#6
Yuguang Zhao, Lu Cai
No abstract text is available yet for this article.
May 8, 2017: EBioMedicine
https://www.readbyqxmd.com/read/28495208/presence-of-viral-microrna-in-extracellular-environments
#7
Catherine DeMarino, Fatah Kashanchi
No abstract text is available yet for this article.
May 5, 2017: EBioMedicine
https://www.readbyqxmd.com/read/28487051/planarians-set-new-paths-for-innate-immune-memory
#8
Samuel T Keating, Niels P Riksen, Mihai G Netea
No abstract text is available yet for this article.
May 5, 2017: EBioMedicine
https://www.readbyqxmd.com/read/28529033/high-throughput-characterization-of-hiv-1-reservoir-reactivation-using-a-single-cell-in-droplet-pcr-assay
#9
Robert W Yucha, Kristen S Hobbs, Emily Hanhauser, Louise E Hogan, Wildaliz Nieves, Mehmet O Ozen, Fatih Inci, Vanessa York, Erica A Gibson, Cassandra Thanh, Hadi Shafiee, Rami El Assal, Maja Kiselinova, Yvonne P Robles, Helen Bae, Kaitlyn S Leadabrand, ShuQi Wang, Steven G Deeks, Daniel R Kuritzkes, Utkan Demirci, Timothy J Henrich
Reactivation of latent viral reservoirs is on the forefront of HIV-1 eradication research. However, it is unknown if latency reversing agents (LRAs) increase the level of viral transcription from cells producing HIV RNA or harboring transcriptionally-inactive (latent) infection. We therefore developed a microfluidic single-cell-in-droplet (scd)PCR assay to directly measure the number of CD4(+) T cells that produce unspliced (us)RNA and multiply spliced (ms)RNA following ex vivo latency reversal with either an histone deacetylase inhibitor (romidepsin) or T cell receptor (TCR) stimulation...
May 4, 2017: EBioMedicine
https://www.readbyqxmd.com/read/28501528/bckdk-of-bcaa-catabolism-cross-talking-with-the-mapk-pathway-promotes-tumorigenesis-of-colorectal-cancer
#10
Peipei Xue, Fanfan Zeng, Qiuhong Duan, Juanjuan Xiao, Lin Liu, Ping Yuan, Linni Fan, Huimin Sun, Olesya S Malyarenko, Hui Lu, Ruijuan Xiu, Shaoqing Liu, Chen Shao, Jianmin Zhang, Wei Yan, Zhe Wang, Jianyong Zheng, Feng Zhu
Branched-chain amino acids catabolism plays an important role in human cancers. Colorectal cancer is the third most commonly diagnosed cancer in males and the second in females, and the new global incidence is over 1.2 million cases. The branched-chain α-keto acid dehydrogenase kinase (BCKDK) is a rate-limiting enzyme in branched-chain amino acids catabolism, which plays an important role in many serious human diseases. Here we investigated that abnormal branched-chain amino acids catabolism in colorectal cancer is a result of the disease process, with no role in disease initiation; BCKDK is widely expressed in colorectal cancer patients, and those patients that express higher levels of BCKDK have shorter survival times than those with lower levels; BCKDK promotes cell transformation or colorectal cancer ex vivo or in vivo...
May 4, 2017: EBioMedicine
https://www.readbyqxmd.com/read/28499926/epigenetic-studies-of-perinatal-determinants-of-later-obesity-link-important-but-previously-unrelated-genetic-and-epidemiological-findings
#11
https://www.readbyqxmd.com/read/28487052/adulthood-sequelae-of-congenital-zika-virus-infection-in-mice
#12
Jing Zou, Pei-Yong Shi
No abstract text is available yet for this article.
May 4, 2017: EBioMedicine
https://www.readbyqxmd.com/read/28506624/emerging-pathogenic-respiratory-mycoplasma-hominis-infections-in-lung-transplant-patients-time-to-reassesses-it-s-role-as-a-pathogen
#13
Owen B Spiller
No abstract text is available yet for this article.
May 3, 2017: EBioMedicine
https://www.readbyqxmd.com/read/28499927/disruption-of-the-hepcidin-ferroportin-regulatory-system-causes-pulmonary-iron-overload-and-restrictive-lung-disease
#14
Joana Neves, Dominik Leitz, Simone Kraut, Christina Brandenberger, Raman Agrawal, Norbert Weissmann, Christian Mühlfeld, Marcus A Mall, Sandro Altamura, Martina U Muckenthaler
Emerging evidence suggests that pulmonary iron accumulation is implicated in a spectrum of chronic lung diseases. However, the mechanism(s) involved in pulmonary iron deposition and its role in the in vivo pathogenesis of lung diseases remains unknown. Here we show that a point mutation in the murine ferroportin gene, which causes hereditary hemochromatosis type 4 (Slc40a1(C326S)), increases iron levels in alveolar macrophages, epithelial cells lining the conducting airways and lung parenchyma, and in vascular smooth muscle cells...
April 29, 2017: EBioMedicine
https://www.readbyqxmd.com/read/28473238/gender-related-responsiveness-to-the-pharmacological-treatment-of-copd-a-first-step-towards-the-personalized-medicine
#15
Luigino Calzetta, Ermanno Puxeddu, Paola Rogliani
The post-hoc analysis of the data collected from the Lung Health Study supports the evolving concept that the impact of COPD may be different between men and women, and supports the hypothesis of a gender-related responsiveness to the pharmacological treatment of COPD. Specific translational studies are needed to assess the real gender-related impact of the currently available dual bronchodilation therapy on the lung function and clinical outcomes of COPD patients. This approach may represent the first affordable step towards a feasible personalized medicine...
April 28, 2017: EBioMedicine
https://www.readbyqxmd.com/read/28499924/hypercholesterolemia-causes-circadian-dysfunction-a-potential-risk-factor-for-cardiovascular-disease
#16
Makoto Akashi, Ritsuko Matsumura, Takahiro Matsuo, Yuki Kubo, Hiroshi Komoda, Koichi Node
Hypercholesterolemia is a well-known risk factor for a wide range of diseases in developed countries. Here, we report that mice lacking functional LDLR (low density lipoprotein receptor), an animal model of human familial hypercholesterolemia, show circadian abnormalities. In free running behavioral experiments in constant darkness, these mice showed a prolonged active phase and distinctly bimodal rhythms. Even when the circadian rhythms were entrained by light and dark cycles, these mice showed a significant attenuation of behavioral onset intensity at the start of the dark period...
April 27, 2017: EBioMedicine
https://www.readbyqxmd.com/read/28483582/the-role-of-heterotypic-denv-specific-cd8-t-lymphocytes-in-an-immunocompetent-mouse-model-of-secondary-dengue-virus-infection
#17
Laura B Talarico, Juan P Batalle, Alana B Byrne, Jorge M Brahamian, Adrián Ferretti, Ayelén G García, Aldana Mauri, Carla Simonetto, Diego R Hijano, Andrea Lawrence, Patricio L Acosta, Mauricio T Caballero, Yésica Paredes Rojas, Lorena I Ibañez, Guillermina A Melendi, Félix A Rey, Elsa B Damonte, Eva Harris, Fernando P Polack
Dengue is the most prevalent arthropod-borne viral disease worldwide and is caused by the four dengue virus serotypes (DENV-1-4). Sequential heterologous DENV infections can be associated with severe disease manifestations. Here, we present an immunocompetent mouse model of secondary DENV infection using non mouse-adapted DENV strains to investigate the pathogenesis of severe dengue disease. C57BL/6 mice infected sequentially with DENV-1 (strain Puerto Rico/94) and DENV-2 (strain Tonga/74) developed low platelet counts, internal hemorrhages, and increase of liver enzymes...
April 27, 2017: EBioMedicine
https://www.readbyqxmd.com/read/28479289/nationwide-surveillance-of-clinical-carbapenem-resistant-enterobacteriaceae-cre-strains-in-china
#18
Rong Zhang, Lizhang Liu, Hongwei Zhou, Edward Waichi Chan, Jiaping Li, Ying Fang, Yi Li, Kang Liao, Sheng Chen
The increasing incidence of carbapenem-resistant Enterobacteriaceae (CRE) - mediated hospital infections in China prompted a need to investigate the genetic basis of emergence of such strains. A nationwide survey was conducted in China covering a total of 1105 CRE strains collected from 25 geographical locales with results showing that acquisition of two carbapenemase genes, blaKPC-2 and blaNDM, was responsible for phenotypic resistance in 90% of the CRE strains tested (58% and 32% respectively), among which several major strain types, such as ST11 of K...
April 26, 2017: EBioMedicine
https://www.readbyqxmd.com/read/28473239/anril-promoter-dna-methylation-a-perinatal-marker-for-later-adiposity
#19
Karen Lillycrop, Robert Murray, Clara Cheong, Ai Ling Teh, Rebecca Clarke-Harris, Sheila Barton, Paula Costello, Emma Garratt, Eloise Cook, Philip Titcombe, Bhuvaneshwari Shunmuganathan, Samantha J Liew, Yong-Cai Chua, Xinyi Lin, Yonghui Wu, Graham C Burdge, Cyrus Cooper, Hazel M Inskip, Neerja Karnani, James C Hopkins, Caroline E Childs, Carolina Paras Chavez, Philip C Calder, Fabian Yap, Yung Seng Lee, Yap Seng Chong, Philip E Melton, Lawrie Beilin, Rae-Chi Huang, Peter D Gluckman, Nick Harvey, Mark A Hanson, Joanna D Holbrook, Keith M Godfrey
Experimental studies show a substantial contribution of early life environment to obesity risk through epigenetic processes. We examined inter-individual DNA methylation differences in human birth tissues associated with child's adiposity. We identified a novel association between the level of CpG methylation at birth within the promoter of the long non-coding RNA ANRIL (encoded at CDKN2A) and childhood adiposity at age 6-years. An association between ANRIL methylation and adiposity was also observed in three additional populations; in birth tissues from ethnically diverse neonates, in peripheral blood from adolescents, and in adipose tissue from adults...
April 26, 2017: EBioMedicine
https://www.readbyqxmd.com/read/28457617/metabolomics-reveals-intratumor-heterogeneity-implications-for-precision-medicine
#20
Xiaojing Liu, Jason W Locasale
No abstract text is available yet for this article.
April 24, 2017: EBioMedicine
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