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EBioMedicine

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https://www.readbyqxmd.com/read/28899606/is-tissue-engineering-of-patient-specific-oral-mucosa-grafts-the-future-of-urethral-reconstruction
#1
Hans M Larsson
No abstract text is available yet for this article.
September 8, 2017: EBioMedicine
https://www.readbyqxmd.com/read/28916157/diabetes-the-tyk2-gene-and-the-interferon-response-in-search-for-environmental-causes
#2
Antonio Toniolo, Richard David Leslie
No abstract text is available yet for this article.
September 6, 2017: EBioMedicine
https://www.readbyqxmd.com/read/28890145/clinical-implications-of-the-association-of-fetal-hemoglobin-with-peripheral-oxygen-saturation-in-sickle-cell-disease
#3
Osheiza Abdulmalik, Kenneth I Ataga
No abstract text is available yet for this article.
September 5, 2017: EBioMedicine
https://www.readbyqxmd.com/read/28890144/adipocyte-epithelial-interactions-and-crohn-s-disease-an-emerging-drug-target
#4
J Calvin Coffey, Miranda Kiernan
No abstract text is available yet for this article.
September 5, 2017: EBioMedicine
https://www.readbyqxmd.com/read/28888925/follicular-helper-t-cells-are-essential-for-the-elimination-of-plasmodium-infection
#5
Damián Pérez-Mazliah, Minh Phuong Nguyen, Caroline Hosking, Sarah McLaughlin, Matthew D Lewis, Irene Tumwine, Prisca Levy, Jean Langhorne
CD4(+) follicular helper T (Tfh) cells have been shown to be critical for the activation of germinal center (GC) B-cell responses. Similar to other infections, Plasmodium infection activates both GC as well as non-GC B cell responses. Here, we sought to explore whether Tfh cells and GC B cells are required to eliminate a Plasmodium infection. A CD4 T cell-targeted deletion of the gene that encodes Bcl6, the master transcription factor for the Tfh program, resulted in complete disruption of the Tfh response to Plasmodium chabaudi in C57BL/6 mice and consequent disruption of GC responses and IgG responses and the inability to eliminate the otherwise self-resolving chronic P...
September 4, 2017: EBioMedicine
https://www.readbyqxmd.com/read/28882756/opening-a-can-of-worms-leprosy-reactions-and-complicit-soil-transmitted-helminths
#6
Deanna A Hagge, Pawan Parajuli, Chhatra B Kunwar, Divya R S J B Rana, Ruby Thapa, Kapil D Neupane, Peter Nicholls, Linda B Adams, Annemieke Geluk, Mahesh Shah, Indra B Napit
BACKGROUND: >94% of new annual leprosy cases are diagnosed in populations co-endemic for soil-transmitted helminths (STH). STH can profoundly dysregulate host immune responses towards Th2 bias, which can be restored over time after deworming. We hypothesize that STH co-infection is associated with leprosy reaction (denoted as simply "reaction" herein) occurrence within a co-endemic population. METHODS: A cohort study was performed on a cohort of Nepalese leprosy patients across treatment and diagnostic classifications who were screened by routine fecal smear microscopy and multiplex quantitative PCR (qPCR) for Ascaris lumbricoides (Al), Strongyloides stercoralis (Ss), Ancyclostoma duodenale (Ad) and Necator americanus (Na)...
September 1, 2017: EBioMedicine
https://www.readbyqxmd.com/read/28877849/not-all-is-cftr-neutrophils-and-cholesterol-in-cystic-fibrosis
#7
Stefano Castellani, Massimo Conese
No abstract text is available yet for this article.
September 1, 2017: EBioMedicine
https://www.readbyqxmd.com/read/28888924/mesothelin-specific-immune-responses-predict-survival-of-patients-with-brain-metastasis
#8
Liu Zhenjiang, Martin Rao, Xiaohua Luo, Elisabeth Sandberg, Jiri Bartek, Esther Schoutrop, Anna von Landenberg, Qingda Meng, Davide Valentini, Thomas Poiret, Georges Sinclair, Inti-Harvey Peredo, Ernest Dodoo, Markus Maeurer
BACKGROUND: Patients with advanced malignancies, e.g. lung cancer, ovarian cancer or melanoma, frequently present with brain metastases. Clinical presentation and disease progression of cancer is in part shaped by the interaction of the immune system with malignant cells. Antigen-targeted immune responses have been implicated in the prolonged survival of patients with cancer. This includes the tumor-associated antigen (TAA) mature mesothelin, a 40kDa cell surface-bound antigen that is overexpressed in several malignancies including lung ovarian and pancreatic cancer...
August 30, 2017: EBioMedicine
https://www.readbyqxmd.com/read/28865747/thalidomide-as-a-potential-hiv-latency-reversal-agent-is-it-the-right-time-to-forget-the-ancestral-sins
#9
Ramachandran Vignesh, Esaki M Shankar
No abstract text is available yet for this article.
August 30, 2017: EBioMedicine
https://www.readbyqxmd.com/read/28864161/mecillinam-reversion-of-resistance-and-how-to-test-it
#10
Niels Frimodt-Moller
No abstract text is available yet for this article.
August 26, 2017: EBioMedicine
https://www.readbyqxmd.com/read/28916156/need-to-face-liver-cirrhosis-after-hcv-cure-with-antivirals
#11
Vicente Soriano, Laura Benitez, Ana Arias, Pablo Barreiro, Carmen de Mendoza
No abstract text is available yet for this article.
August 25, 2017: EBioMedicine
https://www.readbyqxmd.com/read/28864162/treatment-induced-viral-cure-of-hepatitis-c-virus-infected-patients-involves-a-dynamic-interplay-among-three-important-molecular-players-in-lipid-homeostasis-circulating-microrna-mir-24-mir-223-and-proprotein-convertase-subtilisin-kexin-type-9
#12
Anastasia Hyrina, Andrea D Olmstead, Paul Steven, Mel Krajden, Edward Tam, François Jean
In patients with chronic hepatitis C virus (HCV) infection, viral hijacking of the host-cell biosynthetic pathways is associated with altered lipid metabolism, which contributes to disease progression and may influence antiviral response. We investigated the molecular interplay among four key regulators of lipid homeostasis [microRNA (miR)-122, miR-24, miR-223, and proprotein convertase subtilisin/kexin type 9 (PCSK9)] in HCV-infected patients (n=72) who achieved a treatment-based viral cure after interferon-based therapy with first-generation direct-acting antivirals...
September 2017: EBioMedicine
https://www.readbyqxmd.com/read/28855073/reversion-of-high-level-mecillinam-resistance-to-susceptibility-in-escherichia-coli-during-growth-in-urine
#13
Elisabeth Thulin, Måns Thulin, Dan I Andersson
Mecillinam (amdinocillin) is a β-lactam antibiotic used to treat uncomplicated urinary tract infections (UTIs). We have previously shown that inactivation of the Escherichia coli cysB gene is the major cause of mecillinam resistance (Mec(R)) in clinical isolates. In this study, we used different E. coli strains (laboratory and clinical isolates) that were Mec(R) due to cysB mutations to determine how mecillinam susceptibility was affected during growth in urine compared to growth in the commonly used growth medium Mueller Hinton (MHB)...
August 24, 2017: EBioMedicine
https://www.readbyqxmd.com/read/28844411/chlamydia-anti-apoptosis-a-by-product-of-metabolic-reprogramming
#14
Barbara Susanne Sixt, Guido Kroemer
No abstract text is available yet for this article.
August 24, 2017: EBioMedicine
https://www.readbyqxmd.com/read/28851583/chemical-transport-knockout-for-oxidized-vitamin-c-dehydroascorbic-acid-reveals-its-functions-in-vivo
#15
Hongbin Tu, Yu Wang, Hongyan Li, Lauren R Brinster, Mark Levine
Despite its transport by glucose transporters (GLUTs) in vitro, it is unknown whether dehydroascorbic acid (oxidized vitamin C, DHA) has any in vivo function. To investigate, we created a chemical transport knockout model using the vitamin C analog 6-bromo-ascorbate. This analog is transported on sodium-dependent vitamin C transporters but its oxidized form, 6-bromo-dehydroascorbic acid, is not transported by GLUTs. Mice (gulo(-/-)) unable to synthesize ascorbate (vitamin C) were raised on 6-bromo-ascorbate...
August 22, 2017: EBioMedicine
https://www.readbyqxmd.com/read/28844410/safety-tolerability-and-preliminary-efficacy-of-the-anti-fibrotic-small-molecule-pri-724-a-cbp-%C3%AE-catenin-inhibitor-in-patients-with-hepatitis-c-virus-related-cirrhosis-a-single-center-open-label-dose-escalation-phase-1-trial
#16
Kiminori Kimura, Akemi Ikoma, Maki Shibakawa, Shinji Shimoda, Kenichi Harada, Masanao Saio, Jun Imamura, Yosuke Osawa, Masamichi Kimura, Koji Nishikawa, Takuji Okusaka, Satoshi Morita, Kazuaki Inoue, Tatsuya Kanto, Koji Todaka, Yoichi Nakanishi, Michinori Kohara, Masashi Mizokami
BACKGROUND: There is currently no anti-fibrotic drug therapy available to treat hepatitis C virus (HCV) cirrhosis. The aim of this study was to assess the safety, tolerability, and anti-fibrotic effect of PRI-724, a small-molecule modulator of Wnt signaling, in patients with HCV cirrhosis. METHODS: In this single-center, open-label, phase 1 trial, we sequentially enrolled patients with HCV cirrhosis who were classified as Child-Pugh (CP) class A or B. PRI-724 was administered as a continuous intravenous infusion of 10, 40, or 160mg/m(2)/day for six cycles of 1week on and 1week off...
August 19, 2017: EBioMedicine
https://www.readbyqxmd.com/read/28865746/rapid-targeted-next-generation-sequencing-platform-for-molecular-screening-and-clinical-genotyping-in-subjects-with-hemoglobinopathies
#17
Xuan Shang, Zhiyu Peng, Yuhua Ye, Asan, Xinhua Zhang, Yan Chen, Baosheng Zhu, Wangwei Cai, Shaoke Chen, Ren Cai, Xiaoling Guo, Chonglin Zhang, Yuqiu Zhou, Shuodan Huang, Yanhui Liu, Biyan Chen, Shanhuo Yan, Yajun Chen, Hongmei Ding, Xiaolin Yin, Liusong Wu, Jing He, Dongai Huang, Sheng He, Tizhen Yan, Xin Fan, Yuehong Zhou, Xiaofeng Wei, Sumin Zhao, Decheng Cai, Fengyu Guo, Qianqian Zhang, Yun Li, Xuelian Zhang, Haorong Lu, Huajie Huang, Junfu Guo, Fei Zhu, Yuan Yuan, Li Zhang, Na Liu, Zhiming Li, Hui Jiang, Qiang Zhang, Yijia Zhang, Wan Khairunnisa Wan Juhari, Sarifah Hanafi, Wanjun Zhou, Fu Xiong, Huanming Yang, Jian Wang, Bin Alwi Zilfalil, Ming Qi, Yaping Yang, Ye Yin, Mao Mao, Xiangmin Xu
Hemoglobinopathies are among the most common autosomal-recessive disorders worldwide. A comprehensive next-generation sequencing (NGS) test would greatly facilitate screening and diagnosis of these disorders. An NGS panel targeting the coding regions of hemoglobin genes and four modifier genes was designed. We validated the assay by using 2522 subjects affected with hemoglobinopathies and applied it to carrier testing in a cohort of 10,111 couples who were also screened through traditional methods. In the clinical genotyping analysis of 1182 β-thalassemia subjects, we identified a group of additional variants that can be used for accurate diagnosis...
August 17, 2017: EBioMedicine
https://www.readbyqxmd.com/read/28835336/neutrophil-membrane-cholesterol-content-is-a-key-factor-in-cystic-fibrosis-lung-disease
#18
Michelle M White, Patrick Geraghty, Elaine Hayes, Stephen Cox, William Leitch, Bader Alfawaz, Gillian M Lavelle, Oliver J McElvaney, Ryan Flannery, Joanne Keenan, Paula Meleady, Michael Henry, Martin Clynes, Cedric Gunaratnam, Noel G McElvaney, Emer P Reeves
BACKGROUND: Identification of mechanisms promoting neutrophil trafficking to the lungs of patients with cystic fibrosis (CF) is a challenge for next generation therapeutics. Cholesterol, a structural component of neutrophil plasma membranes influences cell adhesion, a key step in transmigration. The effect of chronic inflammation on neutrophil membrane cholesterol content in patients with CF (PWCF) remains unclear. To address this we examined neutrophils of PWCF to evaluate the cause and consequence of altered membrane cholesterol and identified the effects of lung transplantation and ion channel potentiator therapy on the cellular mechanisms responsible for perturbed membrane cholesterol and increased cell adhesion...
August 16, 2017: EBioMedicine
https://www.readbyqxmd.com/read/28827035/results-of-use-of-tissue-engineered-autologous-oral-mucosa-graft-for-urethral-reconstruction-a-multicenter-prospective-observational-trial
#19
Gouya Ram-Liebig, Guido Barbagli, Axel Heidenreich, Dirk Fahlenkamp, Giuseppe Romano, Udo Rebmann, Diana Standhaft, Hermann van Ahlen, Samer Schakaki, Ulf Balsmeyer, Maria-Elsa Spiegeler, Helmut Knispel
BACKGROUND: Harvest of oral mucosa for urethroplasty due to urethral stricture is associated with donor-site-morbidity. We assessed functionality and safety of an authorized tissue-engineered oral mucosa graft (TEOMG) under routine practice in stricture recurrences of any etiology, location, length and severity (real-world data). METHODS: 99 patients from eight centers with heterogenous urethroplasty experience levels were included in this prospective, non-interventional observational study...
August 16, 2017: EBioMedicine
https://www.readbyqxmd.com/read/28826655/subtyping-of-type-1-diabetes-as-classified-by-anti-gad-antibody-ige-levels-and-tyrosine-kinase-2-tyk2-promoter-variant-in-the-japanese
#20
Keiichiro Mine, Kanako Hirakawa, Shiori Kondo, Masae Minami, Akira Okada, Nobutaka Tsutsu, Yasushi Yokogawa, Yumi Hibio, Fumiko Kojima, Shuji Fujimoto, Hironori Kurisaki, Keizo Anzai, Yasunobu Yoshikai, Seiho Nagafuchi
OBJECTIVE: Type 1 diabetes (T1D) is known to be caused by Th1 cell-dependent autoimmunity. Recently, we reported that TYK2 promoter variant serves as a putative virus-induced diabetes susceptibility gene associated with deteriorated interferon-dependent antiviral response. TYK2 is also related to HIES, that is, Th2 cell-dependent. Therefore, TYK2 promoter variant may be also associated with the pathogenesis of T1D, modulating Th1/Th2 balance. RESEARCH DESIGN AND METHODS: We assessed the association between anti- GAD Ab, IgE levels, and TYK2 promoter variant among 313 T1D patients, 184 T2D patients, and 264 YH controls in the Japanese...
August 12, 2017: EBioMedicine
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