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EBioMedicine

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https://www.readbyqxmd.com/read/29157837/deguelin-a-novel-anti-tumorigenic-agent-in-human-esophageal-squamous-cell-carcinoma
#1
Yuh Baba, Yasumasa Kato
No abstract text is available yet for this article.
November 17, 2017: EBioMedicine
https://www.readbyqxmd.com/read/29157835/corrigendum-to-intergenerational-transmission-of-enhanced-seizure-susceptibility-after-febrile-seizures-ebiomedicine-17-2017-206-215
#2
Dengchang Wu, Bo Feng, Yunjian Dai, Xiaohua Wu, Bin Chen, Cenglin Xu, Yangshun Tang, Kang Wang, Shihong Zhang, ShuangWang, Benyan Luo, Zhong Chen
No abstract text is available yet for this article.
November 17, 2017: EBioMedicine
https://www.readbyqxmd.com/read/29157838/impaired-citric-acid-cycle-in-nondiabetic-chronic-kidney-disease
#3
Zhanjun Jia
No abstract text is available yet for this article.
November 14, 2017: EBioMedicine
https://www.readbyqxmd.com/read/29137891/human-leukocyte-antigen-hla-and-gulf-war-illness-gwi-hla-drb1-13-02-spares-subcortical-atrophy-in-gulf-war-veterans
#4
Lisa M James, Peka Christova, Brian E Engdahl, Scott M Lewis, Adam F Carpenter, Apostolos P Georgopoulos
BACKGROUND: Gulf War Illness (GWI) is a multisystem disorder that has affected a substantial number of veterans who served in the 1990-91 Gulf War. The brain is prominently affected, as manifested by the presence of neurological, cognitive and mood symptoms. We reported previously on the protective role of six Human Leukocyte Antigen (HLA) alleles in GWI (Georgopoulos et al., 2016) and their association with regional brain function (James et al., 2016). More recently, we reported on the presence of subcortical brain atrophy in GWI (Christova et al...
November 9, 2017: EBioMedicine
https://www.readbyqxmd.com/read/29129700/paracetamol-medication-during-pregnancy-insights-on-intake-frequencies-dosages-and-effects-on-hematopoietic-stem-cell-populations-in-cord-blood-from-a-longitudinal-prospective-pregnancy-cohort
#5
Lars Bremer, Janina Goletzke, Christian Wiessner, Mirja Pagenkemper, Christina Gehbauer, Heiko Becher, Eva Tolosa, Kurt Hecher, Petra C Arck, Anke Diemert, Gisa Tiegs
BACKGROUND: Paracetamol is the first choice for antipyretic or analgesic treatment throughout pregnancy. Products with Paracetamol are readily available over the counter and therefore easily accessible for self-medication. Epidemiological data on Paracetamol intake pattern during pregnancy and its potential immunological effects are sparse. We aimed to analyze a possible association between Paracetamol medication and numbers of hematopoietic stem cells (HSC) in cord blood. METHODS: The objective was addressed in the PRINCE (PRENATAL DETERMINANTS OF CHILDREN'S HEALTH) study, a population-based prospective pregnancy cohort study initiated in 2011 at the University Medical Center in Hamburg, Germany...
November 9, 2017: EBioMedicine
https://www.readbyqxmd.com/read/29128443/can-thyroid-hormone-analogues-be-used-to-overcome-hypomyelination-and-demyelination-of-the-central-nervous-system
#6
Carlie L Cullen, Kaylene M Young
No abstract text is available yet for this article.
November 7, 2017: EBioMedicine
https://www.readbyqxmd.com/read/29157836/elevated-neopterin-levels-predict-early-death-in-older-hip-fracture-patients
#7
Martin Larsen, Charles Bayard, Hélène Lepetitcorps, Judith Cohen-Bittan, Victor Appay, Jacques Boddaert, Delphine Sauce
Our society faces a major challenge concerning management of the health and socio-economic burden caused by acute physical stress in the older population (+75years). In particular, hip-fracture surgery (HFS) represents a major health care preoccupation, affecting 1.6 million patients worldwide, resulting in a significant drop in life quality and autonomy. The trauma is associated with 20-30% one-year mortality in the elderly. In the present study, we aim to identify factors, which influence and/or predict the outcome of elderly hip- fracture patients (HFP) post-surgery...
November 6, 2017: EBioMedicine
https://www.readbyqxmd.com/read/29129701/biomarkers-for-treatment-monitoring-in-tuberculosis-a-new-hope
#8
Subash Babu
No abstract text is available yet for this article.
November 3, 2017: EBioMedicine
https://www.readbyqxmd.com/read/29129699/deguelin-an-aurora-b-kinase-inhibitor-exhibits-potent-anti-tumor-effect-in-human-esophageal-squamous-cell-carcinoma
#9
Xinfang Yu, Qi Liang, Wenbin Liu, Li Zhou, Wei Li, Haidan Liu
Aurora B kinase has emerged as a key regulator of mitosis and deregulation of Aurora B activity is closely related to the development and progression of human cancers. In the present study, we found that Aurora B is overexpressed in human esophageal squamous cell carcinoma (ESCC), high levels of Aurora B protein were associated with a worse overall survival rate in ESCC patients. Depleting of Aurora B blunted the malignant phenotypes in ESCC cells. Importantly, we demonstrated that a natural compound, deguelin, has a profound anti-tumor effect on ESCC via inhibiting Aurora B activity...
November 3, 2017: EBioMedicine
https://www.readbyqxmd.com/read/29129698/evaluation-of-different-parameters-of-humoral-and-cellular-immune-responses-in-hiv-serodiscordant-heterosexual-couples-humoral-response-potentially-implicated-in-modulating-transmission-rates
#10
María Julia Ruiz, Jimena Salido, Lorena Abusamra, Yanina Ghiglione, Cintia Cevallos, Gabriel Damilano, Ana María Rodriguez, César Trifone, Natalia Laufer, Luis D Giavedoni, Omar Sued, Horacio Salomón, María Magdalena Gherardi, Gabriela Turk
As the HIV/AIDS pandemic still progresses, understanding the mechanisms governing viral transmission as well as protection from HIV acquisition is fundamental. In this context, cohorts of HIV serodiscordant heterosexual couples (SDC) represent a unique tool. The present study was aimed to evaluate specific parameters of innate, cellular and humoral immune responses in SDC. Specifically, plasma levels of cytokines and chemokines, HIV-specific T-cell responses, gp120-specific IgG and IgA antibodies, and HIV-specific antibody-dependent cellular cytotoxicity (ADCC) activity were assessed in nine HIV-exposed seronegative individuals (ESN) and their corresponding HIV seropositive partners (HIV(+)-P), in eighteen chronically infected HIV subjects (C), nine chronically infected subjects known to be HIV transmitters (CT) and ten healthy HIV(-) donors (HD)...
November 3, 2017: EBioMedicine
https://www.readbyqxmd.com/read/29128442/urinary-excretion-of-aluminium-and-silicon-in-secondary-progressive-multiple-sclerosis
#11
Krista Jones, Caroline Linhart, Clive Hawkins, Christopher Exley
BACKGROUND: Progressive multiple sclerosis is a chronic autoimmune condition of unknown aetiology and few therapeutic options. Human exposure to aluminium has been linked with multiple sclerosis and affected individuals are known to excrete unusually high amounts of aluminium in their urine. Silicon-rich mineral waters facilitate the removal of aluminium from the body in urine and herein we have tested their efficacy in affecting urinary excretion of aluminium in individuals diagnosed with secondary progressive multiple sclerosis (SPMS)...
November 1, 2017: EBioMedicine
https://www.readbyqxmd.com/read/29128444/metabolomics-and-gene-expression-analysis-reveal-down-regulation-of-the-citric-acid-tca-cycle-in-non-diabetic-ckd-patients
#12
Stein Hallan, Maryam Afkarian, Leila R Zelnick, Bryan Kestenbaum, Shoba Sharma, Rintaro Saito, Manjula Darshi, Gregory Barding, Daniel Raftery, Wenjun Ju, Matthias Kretzler, Kumar Sharma, Ian H de Boer
Chronic kidney disease (CKD) is a public health problem with very high prevalence and mortality. Yet, there is a paucity of effective treatment options, partly due to insufficient knowledge of underlying pathophysiology. We combined metabolomics (GCMS) with kidney gene expression studies to identify metabolic pathways that are altered in adults with non-diabetic stage 3-4 CKD versus healthy adults. Urinary excretion rate of 27 metabolites and plasma concentration of 33 metabolites differed significantly in CKD patients versus controls (estimate range-68% to +113%)...
October 31, 2017: EBioMedicine
https://www.readbyqxmd.com/read/29104077/assessment-of-atp8b1-deficiency-in-pediatric-patients-with-cholestasis-using-peripheral-blood-monocyte-derived-macrophages
#13
Hisamitsu Hayashi, Sotaro Naoi, Takao Togawa, Yu Hirose, Hiroki Kondou, Yasuhiro Hasegawa, Daiki Abukawa, Mika Sasaki, Koji Muroya, Satoshi Watanabe, Satoshi Nakano, Kei Minowa, Ayano Inui, Akinari Fukuda, Mureo Kasahara, Hironori Nagasaka, Kazuhiko Bessho, Mitsuyoshi Suzuki, Hiroyuki Kusuhara
Progressive familial intrahepatic cholestasis type 1 (PFIC1), a rare inherited recessive disease resulting from a genetic deficiency in ATP8B1, progresses to liver failure. Because of the difficulty of discriminating PFIC1 from other subtypes of PFIC based on its clinical and histological features and genome sequencing, an alternative method for diagnosing PFIC1 is desirable. Herein, we analyzed human peripheral blood monocyte-derived macrophages (HMDM) and found predominant expression of ATP8B1 in interleukin-10 (IL-10)-induced M2c, a subset of alternatively activated macrophages...
October 7, 2017: EBioMedicine
https://www.readbyqxmd.com/read/29156210/corrigendum-to-zika-virus-causes-persistent-infection-in-porcine-conceptuses-and-may-impair-health-in-offspring
#14
Joseph Darbellay, Brian Cox, Kenneth Lai, Mario Delgado-Ortega, Colette Wheler, Donald Wilson, Stewart Walker, Gregory Starrak, Duncan Hockley, Yanyun Huang, George Mutwiri, Andrew Potter, Matthew Gilmour, David Safronetz, Volker Gerdts, Uladzimir Karniychuk
No abstract text is available yet for this article.
November 2017: EBioMedicine
https://www.readbyqxmd.com/read/29129697/dual-mechanisms-for-balancing-th17-and-treg-cell-fate-by-creb
#15
Antony Symons, Wenjun Ouyang
Th17 cells, which express the cytokine IL-17A, and master regulator RORγt, are important in the inflammatory response to fungal and bacterial pathogens, but also have a pathogenic role in many inflammatory disorders. In contrast, regulatory T cells (Treg), expressing the Foxp3 transcription factor, have a suppressive function and can dampen an immune response. The appropriate balance of these distinct effector functions is critical for an effective immune response and autoimmunity can arise if this process goes awry...
November 2017: EBioMedicine
https://www.readbyqxmd.com/read/29122619/aurora-a-functional-single-nucleotide-polymorphism-snp-correlates-with-clinical-outcome-in-patients-with-advanced-solid-tumors-treated-with-alisertib-an-investigational-aurora-a-kinase-inhibitor
#16
Huifeng Niu, Hyunjin Shin, Feng Gao, Jacob Zhang, Brittany Bahamon, Hadi Danaee, Bohuslav Melichar, Russell J Schilder, Robert L Coleman, Gerald Falchook, Antoine Adenis, Kian Behbakht, Angela DeMichele, Elizabeth Claire Dees, Kimberly Perez, Ursula Matulonis, Piotr Sawrycki, Dirk Huebner, Jeffrey Ecsedy
BACKGROUND: Alisertib (MLN8237) is an investigational, oral, selective Aurora A kinase inhibitor. Aurora A contains two functional single nucleotide polymorphisms (SNPs; codon 31 [F/I] and codon 57 [V/I]) that lead to functional changes. This study investigated the prognostic and predictive significance of these SNPs. METHODS: This study evaluated associations between Aurora A SNPs and overall survival (OS) in The Cancer Genome Atlas (TCGA) database. The Aurora A SNPs were also evaluated as predictive biomarkers for clinical outcomes to alisertib in two phase 2 studies (NCT01045421 and NCT01091428)...
November 2017: EBioMedicine
https://www.readbyqxmd.com/read/29113774/restricted-presence-of-pou6f2-in-human-corneal-endothelial-cells-uncovered-by-extension-of-the-promoter-level-expression-atlas
#17
Masahito Yoshihara, Susumu Hara, Motokazu Tsujikawa, Satoshi Kawasaki, Yoshihide Hayashizaki, Masayoshi Itoh, Hideya Kawaji, Kohji Nishida
Corneal endothelial cells (CECs) are essential for maintaining the clarity of the cornea. Because CECs have limited proliferative ability, interest is growing in their potentially therapeutic regeneration from pluripotent stem cells. However, the molecular mechanisms of human CEC differentiation remain largely unknown. To determine the key regulators of CEC characteristics, here we generated a comprehensive promoter-level expression profile of human CECs, using cap analysis of gene expression (CAGE) with a single molecule sequencer...
November 2017: EBioMedicine
https://www.readbyqxmd.com/read/29113773/pairing-cancer-biomarkers-to-biomedicine
#18
EDITORIAL
Seung Ho Shin, Zigang Dong
No abstract text is available yet for this article.
November 2017: EBioMedicine
https://www.readbyqxmd.com/read/29111263/a-new-perspective-of-an-old-villain-revisiting-biomarkers-of-caries-development
#19
Irlan Almeida Freires, José A Lemos, Jacqueline Abranches
No abstract text is available yet for this article.
November 2017: EBioMedicine
https://www.readbyqxmd.com/read/29111262/overcoming-monocarboxylate-transporter-8-mct8-deficiency-to-promote-human-oligodendrocyte-differentiation-and-myelination
#20
Jae Young Lee, Min Joung Kim, Devy Deliyanti, Michael F Azari, Fernando Rossello, Adam Costin, Georg Ramm, Edouard G Stanley, Andrew G Elefanty, Jennifer L Wilkinson-Berka, Steven Petratos
Cell membrane thyroid hormone (TH) transport can be facilitated by the monocarboxylate transporter 8 (MCT8), encoded by the solute carrier family 16 member 2 (SLC16A2) gene. Human mutations of the gene, SLC16A2, result in the X-linked-inherited psychomotor retardation and hypomyelination disorder, Allan-Herndon-Dudley syndrome (AHDS). We posited that abrogating MCT8-dependent TH transport limits oligodendrogenesis and myelination. We show that human oligodendrocytes (OL), derived from the NKX2.1-GFP human embryonic stem cell (hESC) reporter line, express MCT8...
November 2017: EBioMedicine
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