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EBioMedicine

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https://www.readbyqxmd.com/read/29784524/liver-imaging-in-precision-medicine
#1
EDITORIAL
Jiahong Dong, Xiaolong Qi
No abstract text is available yet for this article.
May 18, 2018: EBioMedicine
https://www.readbyqxmd.com/read/29784523/model-animal-mimicking-human-virus-induced-diabetes
#2
Keiichiro Mine, Hirokazu Takahashi, Seiho Nagafuchi
No abstract text is available yet for this article.
May 18, 2018: EBioMedicine
https://www.readbyqxmd.com/read/29779700/plasma-circulating-extracellular-rnas-in-left-ventricular-remodeling-post-myocardial-infarction
#3
Kirsty M Danielson, Ravi Shah, Ashish Yeri, Xiaojun Liu, Fernando Camacho Garcia, Michael Silverman, Kahraman Tanriverdi, Avash Das, Chunyang Xiao, Michael Jerosch-Herold, Bobak Heydari, Siddique Abbasi, Kendall Van Keuren-Jensen, Jane E Freedman, Yaoyu E Wang, Anthony Rosenzweig, Raymond Y Kwong, Saumya Das
Despite substantial declines in mortality following myocardial infarction (MI), subsequent left ventricular remodeling (LVRm) remains a significant long-term complication. Extracellular small non-coding RNAs (exRNAs) have been associated with cardiac inflammation and fibrosis and we hypothesized that they are associated with post-MI LVRm phenotypes. RNA sequencing of exRNAs was performed on plasma samples from patients with "beneficial" (decrease LVESVI ≥ 20%, n = 11) and "adverse" (increase LVESVI ≥ 15%, n = 11) LVRm...
May 17, 2018: EBioMedicine
https://www.readbyqxmd.com/read/29779699/recellularization-of-decellularized-venous-grafts-using-peripheral-blood-a-critical-evaluation
#4
Mia H Rambøl, Jonny Hisdal, Jon O Sundhagen, Jan E Brinchmann, Antonio Rosales
Vascular disease is a major cause of death worldwide, and the growing need for replacement vessels is not fully met by autologous grafts or completely synthetic alternatives. Tissue engineering has emerged as a compelling strategy for the creation of blood vessels for reconstructive surgeries. One promising method to obtain a suitable vessel scaffold is decellularization of donor vascular tissue followed by recellularization with autologous cells. To prevent thrombosis of vascular grafts, a confluent and functional autologous endothelium is required, and researchers are still looking for the optimal cell source and recellularization procedure...
May 17, 2018: EBioMedicine
https://www.readbyqxmd.com/read/29779698/patients-with-concurrent-tuberculosis-and-diabetes-have-a-pro-atherogenic-plasma-lipid-profile
#5
Frank Vrieling, Katharina Ronacher, Léanie Kleynhans, Erik van den Akker, Gerhard Walzl, Tom H M Ottenhoff, Simone A Joosten
BACKGROUND: Type 2 diabetes mellitus (DM) is a major risk factor for development of tuberculosis (TB), however the underlying molecular foundations are unclear. Since lipids play a central role in the development of both DM and TB, lipid metabolism may be important for TB-DM pathophysiology. METHODS: A 1 H NMR spectroscopy-based platform was used to determine 225 lipid and other metabolic intermediates in plasma samples of healthy controls (n = 50) and patients with TB (n = 50), DM (n = 50) or TB-DM (n = 27)...
May 17, 2018: EBioMedicine
https://www.readbyqxmd.com/read/29776747/predicting-treatment-outcomes-the-case-for-hypoxia-gene-signatures
#6
Laure Marignol
No abstract text is available yet for this article.
May 15, 2018: EBioMedicine
https://www.readbyqxmd.com/read/29764768/hydroxylase-activity-of-asph-promotes-hepatocellular-carcinoma-metastasis-through-epithelial-to-mesenchymal-transition-pathway
#7
Qifei Zou, Ying Hou, Haibo Wang, Kui Wang, Xianglei Xing, Yong Xia, Xuying Wan, Jun Li, Binghua Jiao, Jingfeng Liu, Aimin Huang, Dong Wu, Hongjun Xiang, Timothy M Pawlik, Hongyang Wang, Wan Yee Lau, Yizheng Wang, Feng Shen
Over-expression of aspartyl (asparagynal)-β-hydroxylase (ASPH) contributes to hepatocellular carcinoma (HCC) invasiveness, but the role of ASPH hydroxylase activity in this process remains to be defined. As such, the current study investigated the role of ASPH hydroxylase activity in downstream signalling of HCC tumorgenesis and, specifically, metastasis development. Over-expression of wild-type ASPH, but not a hydroxylase mutant, promoted HCC cell migration in vitro, as well as intrahepatic and distant metastases in vivo...
May 12, 2018: EBioMedicine
https://www.readbyqxmd.com/read/29759486/inhibition-of-hdacs-epha2-signaling-axis-with-ww437-demonstrates-promising-preclinical-antitumor-activity-in-breast-cancer
#8
Tao Zhang, Jingjie Li, Xiaojun Ma, Yang Yang, Wei Sun, Wangrui Jin, Lei Wang, Yuan He, Feifei Yang, Zhengfang Yi, Yingqi Hua, Mingyao Liu, Yihua Chen, Zhengdong Cai
Histone deacetylase inhibitors (HDACi) are small molecules targeting epigenetic enzymes approved for hematologic neoplasms, which have also demonstrated clinical activities in solid tumors. In our present study, we screened our internal compound library and discovered a novel HDACi, WW437, with potent anti-breast cancer ability in vitro and in vivo. WW437 significantly inhibited phosphorylated EphA2 and EphA2 expression. Further study demonstrated WW437 blocked HDACs-EphA2 signaling axis in breast cancer. In parallel, we found that EphA2 expression positively correlates with breast cancer progression; and combined use of WW437 and an EphA2 inhibitor (ALW-II-41-27) exerted more remarkable effect on breast cancer growth than either drug alone...
May 11, 2018: EBioMedicine
https://www.readbyqxmd.com/read/29759485/roles-of-alternative-rna-splicing-of-the-bif-1-gene-by-srrm4-during-the-development-of-treatment-induced-neuroendocrine-prostate-cancer
#9
Yu Gan, Yinan Li, Zhi Long, Ahn R Lee, Ning Xie, Jessica M Lovnicki, Yuxin Tang, Xiang Chen, Jiaoti Huang, Xuesen Dong
Treatment-induced neuroendocrine prostate cancer (t-NEPC) is an aggressive subtype of prostate cancer (PCa) that becomes more prevalent when hormonal therapy, chemotherapy, or radiation therapy is applied to patients with metastatic prostate adenocarcinoma (AdPC). How AdPC cells survive these anti-cancer therapies and progress into t-NEPC remains unclear. By comparing the whole transcriptomes between AdPC and t-NEPC, we identified Bif-1, an apoptosis-associated gene, which undergoes alternative RNA splicing in t-NEPC...
May 11, 2018: EBioMedicine
https://www.readbyqxmd.com/read/29759484/runt-related-transcription-factor-1-runx1-promotes-tgf-%C3%AE-induced-renal-tubular-epithelial-to-mesenchymal-transition-emt-and-renal-fibrosis-through-the-pi3k-subunit-p110%C3%AE
#10
Tong Zhou, Maocai Luo, Wei Cai, Siyuan Zhou, Danying Feng, Chundi Xu, Hongyan Wang
Renal fibrosis is widely considered a common mechanism leading to end-stage renal failure. Epithelial-to-mesenchymal transition (EMT) plays important roles in the pathogenesis of renal fibrosis. Runt-related transcription factor 1(RUNX1) plays a vital role in hematopoiesis via Endothelial-to-Hematopoietic Transition (EHT), a process that is conceptually similar to EMT, but its role in EMT and renal fibrosis is unclear. Here, we demonstrate that RUNX1 is overexpressed in the processes of TGF-β-induced partial EMT and renal fibrosis and that the expression level of RUNX1 is SMAD3-dependent...
May 11, 2018: EBioMedicine
https://www.readbyqxmd.com/read/29759483/induction-of-the-immunoproteasome-subunit-lmp7-links-proteostasis-and-immunity-in-%C3%AE-synuclein-aggregation-disorders
#11
Scott Ugras, Malcolm J Daniels, Hossein Fazelinia, Neal S Gould, Anastasia K Yocum, Kelvin C Luk, Esteban Luna, Hua Ding, Chris McKennan, Steven Seeholzer, Dan Martinez, Perry Evans, Daniel Brown, John E Duda, Harry Ischiropoulos
Accumulation of aggregated α-synuclein into Lewy bodies is thought to contribute to the onset and progression of dopaminergic neuron degeneration in Parkinson's disease (PD) and related disorders. Although protein aggregation is associated with perturbation of proteostasis, how α-synuclein aggregation affects the brain proteome and signaling remains uncertain. In a mouse model of α-synuclein aggregation, 6% of 6215 proteins and 1.6% of 8183 phosphopeptides changed in abundance, indicating conservation of proteostasis and phosphorylation signaling...
May 11, 2018: EBioMedicine
https://www.readbyqxmd.com/read/29759482/the-tumor-microenvironment-a-druggable-target-for-metastatic-disease
#12
EDITORIAL
EBioMedicine
No abstract text is available yet for this article.
May 11, 2018: EBioMedicine
https://www.readbyqxmd.com/read/29754884/circulating-salivary-mirna-hsa-mir-221-as-clinically-validated-diagnostic-marker-for-hand-foot-and-mouth-disease-in-pediatric-patients
#13
Nyo Min, Previtha Dawn Sakthi Vale, Anng Anng Wong, Natalie Woon Hui Tan, Chia Yin Chong, Chih-Jung Chen, Robert Y L Wang, Justin Jang Hann Chu
Enhancements in the diagnostic capabilities using host biomarkers are currently much needed where sensitivity and specificity issues plague the diagnosis of Hand, Foot and Mouth Disease (HFMD) in pediatrics clinical samples. We investigated miRNome profiles of HFMD saliva samples against healthy children and developed miRNA-based diagnosis models. Our 6-miRNA scoring model predicted HFMD with an overall accuracy of 85.11% in the training set and 92.86% in the blinded test set of Singapore cohort. Blinded evaluation of the model in Taiwan HFMD cases resulted in 77...
May 10, 2018: EBioMedicine
https://www.readbyqxmd.com/read/29754883/the-promising-role-of-new-generation-hdacis-in-anti-cancer-therapies
#14
Eric Hervouet
No abstract text is available yet for this article.
May 10, 2018: EBioMedicine
https://www.readbyqxmd.com/read/29754882/activation-of-ampk-for-a-break-in-hepatic-lipid-accumulation-and-circulating-cholesterol
#15
Marc Foretz, Benoit Viollet
No abstract text is available yet for this article.
May 10, 2018: EBioMedicine
https://www.readbyqxmd.com/read/29739711/sox30-inhibits-tumor-metastasis-through-attenuating-wnt-signaling-via-transcriptional-and-posttranslational-regulation-of-%C3%AE-catenin-in-lung-cancer
#16
Fei Han, Wen-Bin Liu, Xiao-Yan Shi, Jun-Tang Yang, Xi Zhang, Zhi-Ming Li, Xiao Jiang, Li Yin, Jian-Jun Li, Chuan-Shu Huang, Jia Cao, Jin-Yi Liu
Although high mortality of lung cancer is greatly due to distant metastasis, the mechanism of this metastasis remains unclear. Here, we investigate in lung cancer that SOX30 is sharply under-expressed in metastatic tumors compared with non-metastatic tumors, and suppresses plenty of metastasis related processes or pathways. SOX30 strongly inhibits tumor cell metastasis in vitro and in vivo. Sox30 deficiency promotes lung metastasis in Sox30-/- mice and this uncontrollable lung-metastasis is re-inhibited upon Sox30 re-expression...
May 5, 2018: EBioMedicine
https://www.readbyqxmd.com/read/29735416/corrigendum-to-heterologous-two-dose-vaccination-with-simian-adenovirus-and-poxvirus-vectors-elicits-long-lasting-cellular-immunity-to-influenza-virus-a-in-healthy-adults-ebiomedicine-29-2018-146-154
#17
L Coughlan, S Sridhar, R Payne, M Edmans, A Milicic, N Venkatraman, B Lugonja, L Clifton, C Qi, P M Folegatti, A M Lawrie, R Roberts, H de Graaf, P Sukhtankar, S N Faust, D J M Lewis, T Lambe, A V S Hill, S C Gilbert
No abstract text is available yet for this article.
May 4, 2018: EBioMedicine
https://www.readbyqxmd.com/read/29735415/interventions-targeting-glucocorticoid-kr%C3%A3-ppel-like-factor-15-branched-chain-amino-acid-signaling-improve-disease-phenotypes-in-spinal-muscular-atrophy-mice
#18
Lisa M Walter, Marc-Olivier Deguise, Katharina E Meijboom, Corinne A Betts, Nina Ahlskog, Tirsa L E van Westering, Gareth Hazell, Emily McFall, Anna Kordala, Suzan M Hammond, Frank Abendroth, Lyndsay M Murray, Hannah K Shorrock, Domenick A Prosdocimo, Saptarsi M Haldar, Mukesh K Jain, Thomas H Gillingwater, Peter Claus, Rashmi Kothary, Matthew J A Wood, Melissa Bowerman
The circadian glucocorticoid-Krüppel-like factor 15-branched-chain amino acid (GC-KLF15-BCAA) signaling pathway is a key regulatory axis in muscle, whose imbalance has wide-reaching effects on metabolic homeostasis. Spinal muscular atrophy (SMA) is a neuromuscular disorder also characterized by intrinsic muscle pathologies, metabolic abnormalities and disrupted sleep patterns, which can influence or be influenced by circadian regulatory networks that control behavioral and metabolic rhythms. We therefore set out to investigate the contribution of the GC-KLF15-BCAA pathway in SMA pathophysiology of Taiwanese Smn-/- ;SMN2 and Smn2B/- mouse models...
May 4, 2018: EBioMedicine
https://www.readbyqxmd.com/read/29735413/dna-methylation-patterns-in-normal-tissue-correlate-more-strongly-with-breast-cancer-status-than-copy-number-variants
#19
Yang Gao, Martin Widschwendter, Andrew E Teschendorff
Normal tissue at risk of neoplastic transformation is characterized by somatic mutations, copy-number variation and DNA methylation changes. It is unclear however, which type of alteration may be more informative of cancer risk. We analyzed genome-wide DNA methylation and copy-number calls from the same DNA assay in a cohort of healthy breast samples and age-matched normal samples collected adjacent to breast cancer. Using statistical methods to adjust for cell type heterogeneity, we show that DNA methylation changes can discriminate normal-adjacent from normal samples better than somatic copy-number variants...
May 4, 2018: EBioMedicine
https://www.readbyqxmd.com/read/29735414/adipocyte-derived-lysophosphatidylcholine-activates-adipocyte-and-adipose-tissue-macrophage-nod-like-receptor-protein-3-inflammasomes-mediating-homocysteine-induced-insulin-resistance
#20
Song-Yang Zhang, Yong-Qiang Dong, Pengcheng Wang, Xingzhong Zhang, Yu Yan, Lulu Sun, Bo Liu, Dafang Zhang, Heng Zhang, Huiying Liu, Wei Kong, Gang Hu, Yatrik M Shah, Frank J Gonzalez, Xian Wang, Changtao Jiang
The adipose Nod-like receptor protein 3 (NLRP3) inflammasome senses danger-associated molecular patterns (DAMPs) and initiates insulin resistance, but the mechanisms of adipose inflammasome activation remains elusive. In this study, Homocysteine (Hcy) is revealed to be a DAMP that activates adipocyte NLRP3 inflammasomes, participating in insulin resistance. Hcy-induced activation of NLRP3 inflammasomes were observed in both adipocytes and adipose tissue macrophages (ATMs) and mediated insulin resistance. Lysophosphatidylcholine (lyso-PC) acted as a second signal activator, mediating Hcy-induced adipocyte NLRP3 inflammasome activation...
April 27, 2018: EBioMedicine
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