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Lancet HIV

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https://www.readbyqxmd.com/read/29352724/indications-for-starting-art
#1
Cristina Mussini, Andrea Cossarizza
No abstract text is available yet for this article.
January 15, 2018: Lancet HIV
https://www.readbyqxmd.com/read/29352723/which-hiv-infected-adults-with-high-cd4-t-cell-counts-benefit-most-from-immediate-initiation-of-antiretroviral-therapy-a-post-hoc-subgroup-analysis-of-the-start-trial
#2
Jean-Michel Molina, Birgit Grund, Fred Gordin, Ian Williams, Mauro Schechter, Marcello Losso, Matthew Law, Ernest Ekong, Noluthando Mwelase, Athanasios Skoutelis, Martin J Wiselka, Linos Vandekerckhove, Thomas Benfield, David Munroe, Jens D Lundgren, James D Neaton
BACKGROUND: Immediate initiation of antiretroviral therapy (ART) in asymptomatic adults with CD4 counts higher than 500 cells per μL, as recommended, might not always be possible in resource-limited settings. We aimed to identify subgroups of individuals who would benefit most from immediate treatment. METHODS: The START trial was a randomised controlled trial in asymptomatic, HIV-positive adults previously untreated with ART. Participants with CD4 counts higher than 500 cells per μL were randomly assigned to receive immediate ART or to defer ART until CD4 counts were lower than 350 cells per μL...
January 15, 2018: Lancet HIV
https://www.readbyqxmd.com/read/29329763/efficacy-and-safety-of-varenicline-for-smoking-cessation-in-people-living-with-hiv-in-france-anrs-144-inter-activ-a-randomised-controlled-phase-3-clinical-trial
#3
Patrick Mercié, Julie Arsandaux, Christine Katlama, Samuel Ferret, Aurélie Beuscart, Christian Spadone, Claudine Duvivier, Jacques Reynes, Nathalie Wirth, Laetitia Moinot, Antoine Bénard, David Zucman, Xavier Duval, Jean-Michel Molina, Bruno Spire, Catherine Fagard, Geneviève Chêne
BACKGROUND: Tobacco smoking is common in people living with HIV, but high-quality evidence on interventions for smoking cessation is not available in this population. We aimed to assess the efficacy and safety of varenicline with counselling to aid smoking cessation in people living with HIV. METHODS: The ANRS 144 Inter-ACTIV randomised, parallel, double-blind, multicentre, placebo-controlled phase 3 trial was done at 30 clinical hospital sites in France. People living with HIV who had smoked at least ten cigarettes per day for 1 year or longer, were motivated to stop smoking, were not dependent on another psychoactive substance, and had no history of depression or suicide attempt were eligible...
January 9, 2018: Lancet HIV
https://www.readbyqxmd.com/read/29329762/smoking-and-hiv-confronting-the-epidemic
#4
Philip Diaz, Amy Ferketich
No abstract text is available yet for this article.
January 9, 2018: Lancet HIV
https://www.readbyqxmd.com/read/29199100/universal-test-and-treat-and-the-hiv-epidemic-in-rural-south-africa-a-phase-4-open-label-community-cluster-randomised-trial
#5
Collins C Iwuji, Joanna Orne-Gliemann, Joseph Larmarange, Eric Balestre, Rodolphe Thiebaut, Frank Tanser, Nonhlanhla Okesola, Thembisa Makowa, Jaco Dreyer, Kobus Herbst, Nuala McGrath, Till Bärnighausen, Sylvie Boyer, Tulio De Oliveira, Claire Rekacewicz, Brigitte Bazin, Marie-Louise Newell, Deenan Pillay, François Dabis
BACKGROUND: Universal antiretroviral therapy (ART), as per the 2015 WHO recommendations, might reduce population HIV incidence. We investigated the effect of universal test and treat on HIV acquisition at population level in a high prevalence rural region of South Africa. METHODS: We did a phase 4, open-label, cluster randomised trial of 22 communities in rural KwaZulu-Natal, South Africa. We included individuals residing in the communities who were aged 16 years or older...
November 30, 2017: Lancet HIV
https://www.readbyqxmd.com/read/29199099/prevention-of-hiv-transmission-by-antiretroviral-therapy
#6
Jens Lundgren, Andrew Phillips
No abstract text is available yet for this article.
November 30, 2017: Lancet HIV
https://www.readbyqxmd.com/read/29191441/inadequate-hiv-care-after-incarceration-case-closed
#7
David Alain Wohl, David Loren Rosen
No abstract text is available yet for this article.
November 27, 2017: Lancet HIV
https://www.readbyqxmd.com/read/29191440/predictors-of-linkage-to-hiv-care-and-viral-suppression-after-release-from-jails-and-prisons-a-retrospective-cohort-study
#8
Kelsey B Loeliger, Frederick L Altice, Mayur M Desai, Maria M Ciarleglio, Colleen Gallagher, Jaimie P Meyer
BACKGROUND: Incarceration provides an opportunity for engagement in HIV care but is associated with poor HIV treatment outcomes after release. We aimed to assess post-release linkage to HIV care (LTC) and the effect of transitional case management services. METHODS: To create a retrospective cohort of all adults with HIV released from jails and prisons in Connecticut, USA (2007-14), we linked administrative custody and pharmacy databases with mandatory HIV/AIDS surveillance monitoring and case management data...
November 27, 2017: Lancet HIV
https://www.readbyqxmd.com/read/29174612/mortality-and-its-determinants-in-antiretroviral-treatment-naive-hiv-infected-children-with-suspected-tuberculosis-an-observational-cohort-study
#9
Olivier Marcy, Mathurin Tejiokem, Philippe Msellati, Khanh Truong Huu, Viet Do Chau, Duong Tran Ngoc, Boubacar Nacro, Francis Ateba-Ndongo, Suzie Tetang-Ndiang, Vibol Ung, Bunnet Dim, Leakhena Neou, Laureline Berteloot, Laurence Borand, Christophe Delacourt, Stéphane Blanche
BACKGROUND: Tuberculosis is a major cause of morbidity and mortality in HIV-infected children, but is difficult to diagnose. We studied mortality and its determinants in antiretroviral treatment (ART)-naive HIV-infected children presenting with suspected tuberculosis. METHODS: In this observational cohort study, HIV-infected children aged 13 years or younger with suspected tuberculosis were followed up for 6 months as part of the ANRS 12229 PAANTHER 01 cohort in eight hospitals in four countries (Burkina Faso, Cambodia, Cameroon, and Vietnam)...
November 23, 2017: Lancet HIV
https://www.readbyqxmd.com/read/29174611/preventing-tuberculosis-related-death-in-children-with-hiv
#10
Hafsah Deepa Tootla, Mark Patrick Nicol
No abstract text is available yet for this article.
November 23, 2017: Lancet HIV
https://www.readbyqxmd.com/read/29174085/resistance-to-first-line-art-and-a-role-for-dolutegravir
#11
Richard Kaplan, Robin Wood
No abstract text is available yet for this article.
November 22, 2017: Lancet HIV
https://www.readbyqxmd.com/read/29174084/cost-effectiveness-of-public-health-policy-options-in-the-presence-of-pretreatment-nnrti-drug-resistance-in-sub-saharan-africa-a-modelling-study
#12
Andrew N Phillips, Valentina Cambiano, Fumiyo Nakagawa, Paul Revill, Michael R Jordan, Timothy B Hallett, Meg Doherty, Andrea De Luca, Jens D Lundgren, Mutsa Mhangara, Tsitsi Apollo, John Mellors, Brooke Nichols, Urvi Parikh, Deenan Pillay, Tobias Rinke de Wit, Kim Sigaloff, Diane Havlir, Daniel R Kuritzkes, Anton Pozniak, David van de Vijver, Marco Vitoria, Mark A Wainberg, Elliot Raizes, Silvia Bertagnolio
BACKGROUND: There is concern over increasing prevalence of non-nucleoside reverse-transcriptase inhibitor (NNRTI) resistance in people initiating antiretroviral therapy (ART) in low-income and middle-income countries. We assessed the effectiveness and cost-effectiveness of alternative public health responses in countries in sub-Saharan Africa where the prevalence of pretreatment drug resistance to NNRTIs is high. METHODS: The HIV Synthesis Model is an individual-based simulation model of sexual HIV transmission, progression, and the effect of ART in adults, which is based on extensive published data sources and considers specific drugs and resistance mutations...
November 22, 2017: Lancet HIV
https://www.readbyqxmd.com/read/29170030/economic-incentives-for-hiv-testing-by-adolescents-in-zimbabwe-a-randomised-controlled-trial
#13
Katharina Kranzer, Victoria Simms, Tsitsi Bandason, Ethel Dauya, Grace McHugh, Shungu Munyati, Prosper Chonzi, Suba Dakshina, Hilda Mujuru, Helen A Weiss, Rashida A Ferrand
BACKGROUND: HIV testing is the important entry point for HIV care and prevention service, but uptake of HIV testing and thus coverage of antiretroviral therapy are much lower in older children and adolescents than in adults. We investigated the effect of economic incentives provided to caregivers of children aged 8-17 years on uptake of HIV testing and counselling in Harare, Zimbabwe. METHODS: This randomised controlled trial was nested within a household HIV prevalence survey of children aged 8-17 years in Harare...
November 20, 2017: Lancet HIV
https://www.readbyqxmd.com/read/29170029/crucial-but-understudied-incentives-in-hiv-research
#14
Brandon Brown, Jerome T Galea, Karine Dubé
No abstract text is available yet for this article.
November 20, 2017: Lancet HIV
https://www.readbyqxmd.com/read/29150376/timing-of-antiretroviral-therapy-in-children-with-advanced-hiv
#15
Andrew J Prendergast, Martina Penazzato
No abstract text is available yet for this article.
November 14, 2017: Lancet HIV
https://www.readbyqxmd.com/read/29107564/the-effect-of-art-on-cervical-cancer-precursor-lesions
#16
Henry J C de Vries, Renske D M Steenbergen
No abstract text is available yet for this article.
October 26, 2017: Lancet HIV
https://www.readbyqxmd.com/read/29107562/dolutegravir-as-maintenance-monotherapy-for-hiv-domono-a-phase-2-randomised-non-inferiority-trial
#17
Ingeborg Wijting, Casper Rokx, Charles Boucher, Jeroen van Kampen, Suzan Pas, Theodora de Vries-Sluijs, Carolina Schurink, Hannelore Bax, Maarten Derksen, Eleni-Rosalina Andrinopoulou, Marchina van der Ende, Eric van Gorp, Jan Nouwen, Annelies Verbon, Wouter Bierman, Bart Rijnders
BACKGROUND: The high genetic barrier to resistance of dolutegravir might allow for its use as maintenance monotherapy in patients with HIV. We investigated whether dolutegravir monotherapy was non-inferior to combination antiretroviral therapy (ART) for maintaining virological suppression in patients with HIV-1 infection successfully treated with combination ART. METHODS: We did this open-label, phase 2, randomised non-inferiority trial at two medical centres in the Netherlands...
October 26, 2017: Lancet HIV
https://www.readbyqxmd.com/read/29107561/association-of-antiretroviral-therapy-with-high-risk-human-papillomavirus-cervical-intraepithelial-neoplasia-and-invasive-cervical-cancer-in-women-living-with-hiv-a-systematic-review-and-meta-analysis
#18
Helen Kelly, Helen A Weiss, Yolanda Benavente, Silvia de Sanjose, Philippe Mayaud
BACKGROUND: The interactions between antiretroviral therapy (ART) and high-risk human papillomavirus (HPV) and cervical lesions in women living with HIV are poorly understood. We reviewed the association of ART with these outcomes. METHODS: We did a systematic review and meta-analysis by searching MEDLINE and Embase databases for cross-sectional or cohort studies published in English between Jan 1, 1996, and May 6, 2017, which reported the association of ART with prevalence of high-risk HPV or prevalence, incidence, progression, or regression of histological or cytological cervical abnormalities, or incidence of invasive cervcal cancer...
October 26, 2017: Lancet HIV
https://www.readbyqxmd.com/read/29290227/point-of-care-viral-load-testing-and-differentiated-hiv-care
#19
Jienchi Dorward, Paul K Drain, Nigel Garrett
No abstract text is available yet for this article.
January 2018: Lancet HIV
https://www.readbyqxmd.com/read/29290226/wild-type-hiv-infection-despite-prep-a-lot-to-learn-from-a-case-report
#20
LETTER
Julián Olalla
No abstract text is available yet for this article.
January 2018: Lancet HIV
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