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Lancet HIV

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https://www.readbyqxmd.com/read/29150377/urgent-versus-post-stabilisation-antiretroviral-treatment-in-hospitalised-hiv-infected-children-in-kenya-push-a-randomised-controlled-trial
#1
Irene N Njuguna, Lisa M Cranmer, Vincent O Otieno, Cyrus Mugo, Hellen M Okinyi, Sarah Benki-Nugent, Barbra Richardson, Joshua Stern, Elizabeth Maleche-Obimbo, Dalton C Wamalwa, Grace C John-Stewart
BACKGROUND: Urgent antiretroviral therapy (ART) among hospitalised HIV-infected children might accelerate recovery or worsen outcomes associated with immune reconstitution. We aimed to compare urgent versus post-stabilisation ART among hospitalised HIV-infected children in Kenya. METHODS: In this unmasked randomised controlled trial, we randomly assigned (1:1) HIV-infected, ART-naive children aged 0-12 years who were eligible for treatment to receive ART within 48 h (urgent group) or in 7-14 days (post-stabilisation group) at four hospitals in Kenya (two in Nairobi and two in western Kenya)...
November 14, 2017: Lancet HIV
https://www.readbyqxmd.com/read/29150376/timing-of-antiretroviral-therapy-in-children-with-advanced-hiv
#2
Andrew J Prendergast, Martina Penazzato
No abstract text is available yet for this article.
November 14, 2017: Lancet HIV
https://www.readbyqxmd.com/read/29107564/the-effect-of-art-on-cervical-cancer-precursor-lesions
#3
Henry J C de Vries, Renske D M Steenbergen
No abstract text is available yet for this article.
October 26, 2017: Lancet HIV
https://www.readbyqxmd.com/read/29107563/dolutegravir-monotherapy-as-maintenance-art-bites-the-dust
#4
Janine M Trevillyan, Jennifer F Hoy
No abstract text is available yet for this article.
October 26, 2017: Lancet HIV
https://www.readbyqxmd.com/read/29107562/dolutegravir-as-maintenance-monotherapy-for-hiv-domono-a-phase-2-randomised-non-inferiority-trial
#5
Ingeborg Wijting, Casper Rokx, Charles Boucher, Jeroen van Kampen, Suzan Pas, Theodora de Vries-Sluijs, Carolina Schurink, Hannelore Bax, Maarten Derksen, Eleni-Rosalina Andrinopoulou, Marchina van der Ende, Eric van Gorp, Jan Nouwen, Annelies Verbon, Wouter Bierman, Bart Rijnders
BACKGROUND: The high genetic barrier to resistance of dolutegravir might allow for its use as maintenance monotherapy in patients with HIV. We investigated whether dolutegravir monotherapy was non-inferior to combination antiretroviral therapy (ART) for maintaining virological suppression in patients with HIV-1 infection successfully treated with combination ART. METHODS: We did this open-label, phase 2, randomised non-inferiority trial at two medical centres in the Netherlands...
October 26, 2017: Lancet HIV
https://www.readbyqxmd.com/read/29107561/association-of-antiretroviral-therapy-with-high-risk-human-papillomavirus-cervical-intraepithelial-neoplasia-and-invasive-cervical-cancer-in-women-living-with-hiv-a-systematic-review-and-meta-analysis
#6
Helen Kelly, Helen A Weiss, Yolanda Benavente, Silvia de Sanjose, Philippe Mayaud
BACKGROUND: The interactions between antiretroviral therapy (ART) and high-risk human papillomavirus (HPV) and cervical lesions in women living with HIV are poorly understood. We reviewed the association of ART with these outcomes. METHODS: We did a systematic review and meta-analysis by searching MEDLINE and Embase databases for cross-sectional or cohort studies published in English between Jan 1, 1996, and May 6, 2017, which reported the association of ART with prevalence of high-risk HPV or prevalence, incidence, progression, or regression of histological or cytological cervical abnormalities, or incidence of invasive cervcal cancer...
October 26, 2017: Lancet HIV
https://www.readbyqxmd.com/read/29066095/rapidly-declining-hiv-infection-in-msm-in-central-london
#7
Nneka Nwokolo, Andrew Hill, Alan McOwan, Anton Pozniak
No abstract text is available yet for this article.
October 20, 2017: Lancet HIV
https://www.readbyqxmd.com/read/28993181/towards-a-universal-second-line-fixed-dose-combination-art
#8
Mark A Boyd, David A Cooper, Charles F Gilks
No abstract text is available yet for this article.
October 5, 2017: Lancet HIV
https://www.readbyqxmd.com/read/28993180/efficacy-and-safety-of-switching-from-boosted-protease-inhibitors-plus-emtricitabine-and-tenofovir-disoproxil-fumarate-regimens-to-single-tablet-darunavir-cobicistat-emtricitabine-and-tenofovir-alafenamide-at-48-weeks-in-adults-with-virologically-suppressed
#9
Chloe Orkin, Jean-Michel Molina, Eugenia Negredo, José R Arribas, Joseph Gathe, Joseph J Eron, Erika Van Landuyt, Erkki Lathouwers, Veerle Hufkens, Romana Petrovic, Simon Vanveggel, Magda Opsomer
BACKGROUND: Simplified regimens with reduced pill burden and fewer side-effects are desirable for people living with HIV. We investigated the efficacy and safety of switching to a single-tablet regimen of darunavir, cobicistat, emtricitabine, and tenofovir alafenamide versus continuing a regimen of boosted protease inhibitor, emtricitabine, and tenofovir disoproxil fumarate. METHODS: EMERALD was a phase-3, randomised, active-controlled, open-label, international, multicentre trial, done at 106 sites across nine countries in North America and Europe...
October 5, 2017: Lancet HIV
https://www.readbyqxmd.com/read/28986030/working-towards-hiv-prevention-choices-for-women
#10
Janneke van de Wijgert
No abstract text is available yet for this article.
October 3, 2017: Lancet HIV
https://www.readbyqxmd.com/read/28986029/daily-and-non-daily-pre-exposure-prophylaxis-in-african-women-hptn-067-adapt-cape-town-trial-a-randomised-open-label-phase-2-trial
#11
Linda-Gail Bekker, Surita Roux, Elaine Sebastien, Ntando Yola, K Rivet Amico, James P Hughes, Mark A Marzinke, Craig W Hendrix, Peter L Anderson, Vanessa Elharrar, Michael Stirratt, James F Rooney, Estelle Piwowar-Manning, Susan H Eshleman, Laura McKinstry, Maoji Li, Bonnie J Dye, Robert M Grant
BACKGROUND: The relative feasibility and acceptability of daily versus non-daily dosing of oral HIV pre-exposure prophylaxis (PrEP) among women are unknown. We aimed to investigate the feasibility of non-daily PrEP regimens in adult women. METHODS: We did a randomised, open-label, phase 2 clinical trial (HPTN 067/ADAPT) of oral PrEP with emtricitabine plus tenofovir disoproxil fumarate at a research centre in Cape Town, South Africa. Participants were adult women (age ≥18 years) who received directly observed dosing once a week for 5 weeks followed by random assignment (1:1:1) at week 6 to one of three unblinded PrEP regimens for self-administered dosing over 24 weeks: daily; time-driven (twice a week plus a post-sex dose); or event-driven (one tablet both before and after sex)...
October 3, 2017: Lancet HIV
https://www.readbyqxmd.com/read/28978418/socioeconomic-empowerment-in-an-acute-hiv-cohort
#12
Praphan Phanuphak, Nittaya Phanuphak
No abstract text is available yet for this article.
September 29, 2017: Lancet HIV
https://www.readbyqxmd.com/read/28978417/detection-and-treatment-of-fiebig-stage-i-hiv-1-infection-in-young-at-risk-women-in-south-africa-a-prospective-cohort-study
#13
Krista L Dong, Amber Moodley, Douglas S Kwon, Musie S Ghebremichael, Mary Dong, Nasreen Ismail, Zaza M Ndhlovu, Jenniffer M Mabuka, Daniel M Muema, Karyn Pretorius, Nina Lin, Bruce D Walker, Thumbi Ndung'u
BACKGROUND: HIV incidence among young women in sub-Saharan Africa remains high and their inclusion in vaccine and cure efforts is crucial. We aimed to establish a cohort of young women detected during Fiebig stage I acute HIV infection in whom treatment was initiated immediately after diagnosis to advance research in this high-risk group. METHODS: 945 women aged 18-23 years in KwaZulu-Natal, South Africa, who were HIV uninfected and sexually active consented to HIV-1 RNA testing twice a week and biological sampling and risk assessment every 3 months during participation in a 48-96 week life-skills and job-readiness programme...
September 29, 2017: Lancet HIV
https://www.readbyqxmd.com/read/28967581/hiv-diagnosis-increasing-in-older-adults-in-europe
#14
Janet Seeley
No abstract text is available yet for this article.
September 26, 2017: Lancet HIV
https://www.readbyqxmd.com/read/28919303/acquisition-of-wild-type-hiv-1-infection-in-a-patient-on-pre-exposure-prophylaxis-with-high-intracellular-concentrations-of-tenofovir-diphosphate-a-case-report
#15
Elske Hoornenborg, Maria Prins, Roel C A Achterbergh, Lycke R Woittiez, Marion Cornelissen, Suzanne Jurriaans, Neeltje A Kootstra, Peter L Anderson, Peter Reiss, Henry J C de Vries, Jan M Prins, Godelieve J de Bree
BACKGROUND: Pre-exposure prophylaxis (PrEP) with emtricitabine and tenofovir disoproxil fumarate is highly effective against acquisition of HIV infection, and only two cases of infection with a multidrug-resistant virus have been reported under adequate long-term adherence, as evidenced by tenofovir diphosphate concentrations in dried blood spots. We report a case of wild-type HIV-1 infection despite consistent use of emtricitabine and tenofovir disoproxil fumarate. METHODS: The patient participated in the Amsterdam PrEP project, a demonstration project of daily and event-driven PrEP...
September 14, 2017: Lancet HIV
https://www.readbyqxmd.com/read/28867268/control-of-hiv-epidemic-improve-access-to-testing-and-art
#16
Sten H Vermund
No abstract text is available yet for this article.
August 31, 2017: Lancet HIV
https://www.readbyqxmd.com/read/28867267/testing-and-linkage-to-hiv-care-in-china-a-cluster-randomised-trial
#17
Zunyou Wu, Zhenzhu Tang, Yurong Mao, Paul Van Veldhuisen, Walter Ling, David Liu, Zhiyong Shen, Roger Detels, Guanghua Lan, Lynda Erinoff, Robert Lindblad, Diane Gu, Houlin Tang, Lian Hu, Qiuying Zhu, Li Lu, Neal Oden, Albert L Hasson, Yan Zhao, Jennifer M McGoogan, Xianmin Ge, Nanci Zhang, Keming Rou, Jinhui Zhu, Hui Wei, Cynthia X Shi, Xia Jin, Jian Li, Julio S G Montaner
BACKGROUND: Multistage, stepwise HIV testing and treatment procedures can result in lost opportunities to provide timely antiretroviral therapy (ART). Incomplete engagement of patients along the care cascade translates into high preventable mortality. We aimed to identify whether a structural intervention to streamline testing and linkage to HIV health care would improve testing completeness, ART initiation, and viral suppression and reduce mortality. METHODS: We did a cluster-randomised, controlled trial in 12 hospitals in Guangxi, China...
August 31, 2017: Lancet HIV
https://www.readbyqxmd.com/read/29096786/taking-the-long-view-in-a-personalised-approach-to-hiv-care
#18
Jeffrey V Lazarus, Simon E Barton, José I Bernardino
No abstract text is available yet for this article.
November 2017: Lancet HIV
https://www.readbyqxmd.com/read/29096785/u-u-taking-off-in-2017
#19
EDITORIAL
The Lancet Hiv
No abstract text is available yet for this article.
November 2017: Lancet HIV
https://www.readbyqxmd.com/read/28967582/new-hiv-diagnoses-among-adults-aged-50-years-or-older-in-31-european-countries-2004-15-an-analysis-of-surveillance-data
#20
Lara Tavoschi, Joana Gomes Dias, Anastasia Pharris
BACKGROUND: The HIV burden is increasing in older adults in the European Union (EU) and European Economic Area (EEA). We investigated factors associated with HIV diagnosis in older adults in the 31 EU/EEA countries during a 12 year period. METHODS: In this analysis of surveillance data, we compared data from older people (aged ≥50 years) with those from younger people (aged 15-49 years). We extracted new HIV diagnoses reported to the European Surveillance System between Jan 1, 2004, and Dec 31, 2015, and stratified them by age, sex, migration status, transmission route, and CD4 cell count...
November 2017: Lancet HIV
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