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Lancet HIV

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https://www.readbyqxmd.com/read/28233661/hiv-prevention-resources-time-to-move-toward-affordability
#1
April D Kimmel, Denis Nash
No abstract text is available yet for this article.
February 20, 2017: Lancet HIV
https://www.readbyqxmd.com/read/28233660/prep-for-key-populations-in-combination-hiv-prevention-in-narobi-a-mathematical-modelling-study
#2
Ide Cremin, Lyle McKinnon, Joshua Kimani, Peter Cherutich, Gloria Gakii, Festus Muriuki, Katharine Kripke, Robert Hecht, Michael Kiragu, Jennifer Smith, Wes Hinsley, Lawrence Gelmon, Timothy B Hallett
BACKGROUND: The HIV epidemic in the population of Nairobi as a whole is in decline, but a concentrated sub-epidemic persists in key populations. We aimed to identify an optimal portfolio of interventions to reduce HIV incidence for a given budget and to identify the circumstances in which pre-exposure prophylaxis (PrEP) could be used in Nairobi, Kenya. METHODS: A mathematical model was developed to represent HIV transmission in specific key populations (female sex workers, male sex workers, and men who have sex with men [MSM]) and among the wider population of Nairobi...
February 20, 2017: Lancet HIV
https://www.readbyqxmd.com/read/28219619/effect-of-availability-of-hiv-self-testing-on-hiv-testing-frequency-in-gay-and-bisexual-men-at-high-risk-of-infection-forth-a-waiting-list-randomised-controlled-trial
#3
Muhammad S Jamil, Garrett Prestage, Christopher K Fairley, Andrew E Grulich, Kirsty S Smith, Marcus Chen, Martin Holt, Anna M McNulty, Benjamin R Bavinton, Damian P Conway, Handan Wand, Phillip Keen, Jack Bradley, Johann Kolstee, Colin Batrouney, Darren Russell, Matthew Law, John M Kaldor, Rebecca J Guy
BACKGROUND: Frequent testing of individuals at high risk of HIV is central to current prevention strategies. We aimed to determine if HIV self-testing would increase frequency of testing in high-risk gay and bisexual men, with a particular focus on men who delayed testing or had never been tested before. METHODS: In this randomised trial, HIV-negative high-risk gay and bisexual men who reported condomless anal intercourse or more than five male sexual partners in the past 3 months were recruited at three clinical and two community-based sites in Australia...
February 16, 2017: Lancet HIV
https://www.readbyqxmd.com/read/28219618/hiv-self-testing-in-high-risk-populations
#4
Victoria Frye, Beryl A Koblin
No abstract text is available yet for this article.
February 16, 2017: Lancet HIV
https://www.readbyqxmd.com/read/28219611/integrase-inhibitors-go-head-to-head
#5
Tristan Barber
No abstract text is available yet for this article.
February 14, 2017: Lancet HIV
https://www.readbyqxmd.com/read/28219610/bictegravir-versus-dolutegravir-each-with-emtricitabine-and-tenofovir-alafenamide-for-initial-treatment-of-hiv-1-infection-a-randomised-double-blind-phase-2-trial
#6
Paul E Sax, Edwin DeJesus, Gordon Crofoot, Douglas Ward, Paul Benson, Robin Dretler, Anthony Mills, Cynthia Brinson, Julie Peloquin, Xuelian Wei, Kirsten White, Andrew Cheng, Hal Martin, Erin Quirk
BACKGROUND: All recent treatment guidelines recommend integrase strand transfer inhibitors (INSTIs) as components of initial HIV therapy. Bictegravir, a novel, once-daily, unboosted INSTI, showed potent activity in a 10 day monotherapy study and has a high in-vitro resistance barrier. On the basis of these results, we did a phase 2 trial comparing bictegravir with dolutegravir. METHODS: In this randomised, double-blind, phase 2 trial, we recruited previously untreated adults (aged ≥18 years) with HIV-1 infections from 22 outpatient centres in the USA...
February 14, 2017: Lancet HIV
https://www.readbyqxmd.com/read/28188031/hiv-in-transgender-women-in-brazil
#7
Tonia Poteat, Andrea L Wirtz
No abstract text is available yet for this article.
February 7, 2017: Lancet HIV
https://www.readbyqxmd.com/read/28188030/unveiling-of-hiv-dynamics-among-transgender-women-a-respondent-driven-sampling-study-in-rio-de-janeiro-brazil
#8
Beatriz Grinsztejn, Emilia M Jalil, Laylla Monteiro, Luciane Velasque, Ronaldo I Moreira, Ana Cristina F Garcia, Cristiane V Castro, Alícia Krüger, Paula M Luz, Albert Y Liu, Willi McFarland, Susan Buchbinder, Valdilea G Veloso, Erin C Wilson
BACKGROUND: The burden of HIV in transgender women (transwomen) in Brazil remains unknown. We aimed to estimate HIV prevalence among transwomen in Rio de Janeiro and to identify predictors of newly diagnosed HIV infections. METHODS: We recruited transwomen from Rio de Janeiro, Brazil, by respondent-driven sampling. Eligibility criteria were self-identification as transwomen, being 18 years of age or older, living in Rio de Janeiro or its metropolitan area, and having a valid peer recruitment coupon...
February 7, 2017: Lancet HIV
https://www.readbyqxmd.com/read/28159548/prevalence-and-burden-of-toxoplasma-gondii-infection-in-hiv-infected-people-a-systematic-review-and-meta-analysis
#9
Ze-Dong Wang, Shu-Chao Wang, Huan-Huan Liu, Hong-Yu Ma, Zhong-Yu Li, Feng Wei, Xing-Quan Zhu, Quan Liu
BACKGROUND: Worldwide, 30% of the world's population have antibodies to the intracellular protozoan parasite Toxoplasma gondii and about 36·7 million people are infected with HIV, but little is known about the prevalence of co-infection with T gondii and HIV. We aimed to characterise the epidemiology and burden of T gondii co-infection in people with HIV infection. METHODS: In this systematic review and meta-analysis, we searched PubMed, Embase, Google Scholar, ScienceDirect, Chinese Web of Knowledge, Wanfang, and Chongqing VIP databases for studies reporting T gondii infection in HIV-infected people from inception to Feb 29, 2016...
January 31, 2017: Lancet HIV
https://www.readbyqxmd.com/read/28159547/toxoplasma-gondii-and-hiv-a-never-ending-story
#10
Veeranoot Nissapatorn
No abstract text is available yet for this article.
January 31, 2017: Lancet HIV
https://www.readbyqxmd.com/read/28153471/is-90-90-90-achievable
#11
George W Rutherford, Andrew Anglemyer
No abstract text is available yet for this article.
January 30, 2017: Lancet HIV
https://www.readbyqxmd.com/read/28153470/from-hiv-infection-to-therapeutic-response-a-population-based-longitudinal-hiv-cascade-of-care-study-in-kwazulu-natal-south-africa
#12
Noah Haber, Frank Tanser, Jacob Bor, Kevindra Naidu, Tinofa Mutevedzi, Kobus Herbst, Kholoud Porter, Deenan Pillay, Till Bärnighausen
BACKGROUND: Standard approaches to estimation of losses in the HIV cascade of care are typically cross-sectional and do not include the population stages before linkage to clinical care. We used indiviual-level longitudinal cascade data, transition by transition, including population stages, both to identify the health-system losses in the cascade and to show the differences in inference between standard methods and the longitudinal approach. METHODS: We used non-parametric survival analysis to estimate a longitudinal HIV care cascade for a large population of people with HIV residing in rural KwaZulu-Natal, South Africa...
January 30, 2017: Lancet HIV
https://www.readbyqxmd.com/read/28130027/criminal-law-sex-work-hiv-need-for-multi-level-research
#13
Marie-Claude Boily, Kate Shannon
No abstract text is available yet for this article.
January 24, 2017: Lancet HIV
https://www.readbyqxmd.com/read/28130026/national-sex-work-policy-and-hiv-prevalence-among-sex-workers-an-ecological-regression-analysis-of-27-european-countries
#14
Aaron Reeves, Sarah Steele, David Stuckler, Martin McKee, Andrew Amato-Gauci, Jan C Semenza
BACKGROUND: Sex workers are disproportionately affected by HIV compared with the general population. Most studies of HIV risk among sex workers have focused on individual-level risk factors, with few studies assessing potential structural determinants of HIV risk. In this Article, we examine whether criminal laws around sex work are associated with HIV prevalence among female sex workers. METHOD: We estimate cross-sectional, ecological regression models with data from 27 European countries on HIV prevalence among sex workers from the European Centre for Disease Control; sex-work legislation from the US State Department's Country Reports on Human Rights Practices and country-specific legal documents; the rule of law and gross-domestic product per capita, adjusted for purchasing power, from the World Bank; and the prevalence of injecting drug use among sex workers...
January 24, 2017: Lancet HIV
https://www.readbyqxmd.com/read/28126485/hiv-and-disabilities-time-for-more-and-better-data
#15
Waimar Tun, Suzanne Leclerc-Madlala
No abstract text is available yet for this article.
January 23, 2017: Lancet HIV
https://www.readbyqxmd.com/read/28126484/prevalence-of-hiv-infection-among-people-with-disabilities-a-population-based-observational-study-in-yaound%C3%A3-cameroon-handivih
#16
Pierre De Beaudrap, Gervais Beninguisse, Estelle Pasquier, Alice Tchoumkeu, Adonis Touko, Frida Essomba, Aude Brus, Toyin Janet Aderemi, Jill Hanass-Hancock, Arne Henning Eide, Muriel Mac-Seing, Daniel Mont
BACKGROUND: In resource-limited settings, people with disabilities have been left behind in the response to HIV. In the HandiVIH study, we estimate and compare HIV prevalence and associated risk factors between people with and without disabilities. METHODS: In this cross-sectional, population-based, observational study, we used two-phase random sampling to recruit adults with disabilities and a control group matched for age, sex, and residential location from households of the general population...
January 23, 2017: Lancet HIV
https://www.readbyqxmd.com/read/28063815/effect-of-immediate-initiation-of-antiretroviral-therapy-on-risk-of-severe-bacterial-infections-in-hiv-positive-people-with-cd4-cell-counts-of-more-than-500-cells-per-%C3%AE-l-secondary-outcome-results-from-a-randomised-controlled-trial
#17
Jemma O'Connor, Michael J Vjecha, Andrew N Phillips, Brian Angus, David Cooper, Beatriz Grinsztejn, Gustavo Lopardo, Satyajit Das, Robin Wood, Aimee Wilkin, Hartwig Klinker, Pacharee Kantipong, Karin L Klingman, David Jilich, Elbushra Herieka, Eileen Denning, Ibrahim Abubakar, Fred Gordin, Jens D Lundgren
BACKGROUND: The effects of antiretroviral therapy on risk of severe bacterial infections in people with high CD4 cell counts have not been well described. In this study, we aimed to quantify the effects of immediate versus deferred ART on the risk of severe bacterial infection in people with high CD4 cell counts in a preplanned analysis of the START trial. METHODS: The START trial was a randomised controlled trial in ART-naive HIV-positive patients with CD4 cell count of more than 500 cells per μL assigned to immediate ART or deferral until their CD4 cell counts were lower than 350 cells per μL...
January 4, 2017: Lancet HIV
https://www.readbyqxmd.com/read/28063814/severe-bacterial-infections-overlooked-opportunistic-diseases
#18
Xavier Anglaret, Serge P Eholie
No abstract text is available yet for this article.
January 4, 2017: Lancet HIV
https://www.readbyqxmd.com/read/27989576/population-levels-and-geographical-distribution-of-hiv-rna-in-rural-ugandan-and-kenyan-communities-including-serodiscordant-couples-a-cross-sectional-analysis
#19
Vivek Jain, Maya L Petersen, Teri Liegler, Dathan M Byonanebye, Dalsone Kwarisiima, Gabriel Chamie, Norton Sang, Doug Black, Tamara D Clark, Andras Ladai, Albert Plenty, Jane Kabami, Emmanuel Ssemmondo, Elizabeth A Bukusi, Craig R Cohen, Edwin D Charlebois, Moses R Kamya, Diane V Havlir
BACKGROUND: As sub-Saharan Africa transitions to a new era of universal antiretroviral therapy (ART), up-to-date assessments of population-level HIV RNA suppression are needed to inform interventions to optimise ART delivery. We sought to measure population viral load metrics to assess viral suppression and characterise demographic groups and geographical locations with high-level detectable viraemia in east Africa. METHODS: The Sustainable East Africa Research in Community Health (SEARCH) study is a cluster-randomised controlled trial of an HIV test-and-treat strategy in 32 rural communities in Uganda and Kenya, selected on the basis of rural setting, having an approximate population of 10 000 people, and being within the catchment area of a President's Emergency Plan for AIDS Relief-supported HIV clinic...
December 15, 2016: Lancet HIV
https://www.readbyqxmd.com/read/27989575/the-holy-grail-of-hiv-programme-effectiveness
#20
Sunil Suhas Solomon
No abstract text is available yet for this article.
December 15, 2016: Lancet HIV
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