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Lancet HIV

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https://www.readbyqxmd.com/read/28262574/health-adjusted-life-expectancy-in-hiv-positive-and-hiv-negative-men-and-women-in-british-columbia-canada-a-population-based-observational-cohort-study
#1
Robert S Hogg, Oghenowede Eyawo, Alexandra B Collins, Wendy Zhang, Shahab Jabbari, Mark W Hull, Viviane Dias Lima, Tareq Ahmed, Claire E Kendall, Keri N Althoff, Amy C Justice, Rolando Barrios, Jeannie Shoveller, Julio S G Montaner
BACKGROUND: We sought to understand whether people living with HIV (PLHIV) ever on highly active antiretroviral therapy (ART) follow a pattern where morbidity is compressed into the last years of life or lessened as people age. We aimed to estimate health-adjusted life expectancy (HALE) among adults living with and without HIV, and examine dependency between causes of comorbidities. METHODS: The Comparative Outcomes and Service Utilization Trends (COAST) study is a retrospective cohort of adults (≥20 years) including all known PLHIV and a 10% random sample of the general population of British Columbia, and with longitudinal data spanning from April 1, 1996, to Dec 31, 2012...
March 2, 2017: Lancet HIV
https://www.readbyqxmd.com/read/28262573/liver-disease-and-healthy-life-expectancy-with-hiv
#2
Hugo Perazzo, Paula M Luz
No abstract text is available yet for this article.
March 2, 2017: Lancet HIV
https://www.readbyqxmd.com/read/28259777/switching-from-tenofovir-disoproxil-fumarate-to-tenofovir-alafenamide-coformulated-with-rilpivirine-and-emtricitabine-in-virally-suppressed-adults-with-hiv-1-infection-a-randomised-double-blind-multicentre-phase-3b-non-inferiority-study
#3
Chloe Orkin, Edwin DeJesus, Moti Ramgopal, Gordon Crofoot, Peter Ruane, Anthony LaMarca, Anthony Mills, Bernard Vandercam, Joseph de Wet, Jürgen Rockstroh, Adriano Lazzarin, Bart Rijnders, Daniel Podzamczer, Anders Thalme, Marcel Stoeckle, Danielle Porter, Hui C Liu, Andrew Cheng, Erin Quirk, Devi SenGupta, Huyen Cao
BACKGROUND: Tenofovir alafenamide, a tenofovir prodrug, results in 90% lower tenofovir plasma concentrations than does tenofovir disproxil fumarate, thereby minimising bone and renal risks. We investigated the efficacy, safety, and tolerability of switching to a single-tablet regimen containing rilpivirine, emtricitabine, and tenofovir alafenamide compared with remaining on rilpivirine, emtricitabine, and tenofovir disoproxil fumarate. METHODS: In this randomised, double-blind, multicentre, placebo-controlled, non-inferiority trial, HIV-1-infected adults were screened and enrolled at 119 hospitals in 11 countries in North America and Europe...
March 1, 2017: Lancet HIV
https://www.readbyqxmd.com/read/28259776/switching-from-efavirenz-emtricitabine-and-tenofovir-disoproxil-fumarate-to-tenofovir-alafenamide-coformulated-with-rilpivirine-and-emtricitabine-in-virally-suppressed-adults-with-hiv-1-infection-a-randomised-double-blind-multicentre-phase-3b-non-inferiority
#4
Edwin DeJesus, Moti Ramgopal, Gordon Crofoot, Peter Ruane, Anthony LaMarca, Anthony Mills, Claudia T Martorell, Joseph de Wet, Hans-Jürgen Stellbrink, Jean-Michel Molina, Frank A Post, Ignacio Pérez Valero, Danielle Porter, YaPei Liu, Andrew Cheng, Erin Quirk, Devi SenGupta, Huyen Cao
BACKGROUND: Tenofovir alafenamide is a prodrug that reduces tenofovir plasma concentrations by 90% compared with tenofovir disoproxil fumarate, thereby decreasing bone and renal risks. The coformulation of rilpivirine, emtricitabine, and tenofovir alafenamide has recently been approved, and we aimed to investigate the efficacy, safety, and tolerability of switching to this regimen compared with remaining on coformulated efavirenz, emtricitabine, and tenofovir disoproxil fumarate. METHODS: In this randomised, double-blind, placebo-controlled, non-inferiority trial, HIV-1-infected adults were enrolled at 120 hospitals and outpatient clinics in eight countries in North America and Europe...
March 1, 2017: Lancet HIV
https://www.readbyqxmd.com/read/28259775/tenofovir-prodrugs-similar-but-not-the-same
#5
Anne Bruggemans, Zeger Debyser
No abstract text is available yet for this article.
March 1, 2017: Lancet HIV
https://www.readbyqxmd.com/read/28256422/geographical-disparities-in-hiv-prevalence-and-care-among-men-who-have-sex-with-men-in-malawi-results-from-a-multisite-cross-sectional-survey
#6
Andrea L Wirtz, Gift Trapence, Dunker Kamba, Victor Gama, Rodney Chalera, Vincent Jumbe, Rosemary Kumwenda, Marriam Mangochi, Stephane Helleringer, Chris Beyrer, Stefan Baral
BACKGROUND: Epidemiological assessment of geographical heterogeneity of HIV among men who have sex with men (MSM) is necessary to inform HIV prevention and care strategies in the more generalised HIV epidemics across sub-Saharan Africa, including Malawi. We aimed to measure the HIV prevalence, risks, and access to HIV care among MSM across multiple localities to better inform HIV programming for MSM in Malawi. METHODS: Between Aug 1, 2011, and Sept 13, 2014, we recruited MSM into cross-sectional research via respondent-driven sampling (RDS) in seven districts of Malawi...
February 27, 2017: Lancet HIV
https://www.readbyqxmd.com/read/28256421/improving-hiv-prevention-and-care-for-african-gbmsm
#7
Susan M Graham, Gary W Harper
No abstract text is available yet for this article.
February 27, 2017: Lancet HIV
https://www.readbyqxmd.com/read/28233661/hiv-prevention-resources-time-to-move-toward-affordability
#8
April D Kimmel, Denis Nash
No abstract text is available yet for this article.
February 20, 2017: Lancet HIV
https://www.readbyqxmd.com/read/28233660/prep-for-key-populations-in-combination-hiv-prevention-in-narobi-a-mathematical-modelling-study
#9
Ide Cremin, Lyle McKinnon, Joshua Kimani, Peter Cherutich, Gloria Gakii, Festus Muriuki, Katharine Kripke, Robert Hecht, Michael Kiragu, Jennifer Smith, Wes Hinsley, Lawrence Gelmon, Timothy B Hallett
BACKGROUND: The HIV epidemic in the population of Nairobi as a whole is in decline, but a concentrated sub-epidemic persists in key populations. We aimed to identify an optimal portfolio of interventions to reduce HIV incidence for a given budget and to identify the circumstances in which pre-exposure prophylaxis (PrEP) could be used in Nairobi, Kenya. METHODS: A mathematical model was developed to represent HIV transmission in specific key populations (female sex workers, male sex workers, and men who have sex with men [MSM]) and among the wider population of Nairobi...
February 20, 2017: Lancet HIV
https://www.readbyqxmd.com/read/28219619/effect-of-availability-of-hiv-self-testing-on-hiv-testing-frequency-in-gay-and-bisexual-men-at-high-risk-of-infection-forth-a-waiting-list-randomised-controlled-trial
#10
Muhammad S Jamil, Garrett Prestage, Christopher K Fairley, Andrew E Grulich, Kirsty S Smith, Marcus Chen, Martin Holt, Anna M McNulty, Benjamin R Bavinton, Damian P Conway, Handan Wand, Phillip Keen, Jack Bradley, Johann Kolstee, Colin Batrouney, Darren Russell, Matthew Law, John M Kaldor, Rebecca J Guy
BACKGROUND: Frequent testing of individuals at high risk of HIV is central to current prevention strategies. We aimed to determine if HIV self-testing would increase frequency of testing in high-risk gay and bisexual men, with a particular focus on men who delayed testing or had never been tested before. METHODS: In this randomised trial, HIV-negative high-risk gay and bisexual men who reported condomless anal intercourse or more than five male sexual partners in the past 3 months were recruited at three clinical and two community-based sites in Australia...
February 16, 2017: Lancet HIV
https://www.readbyqxmd.com/read/28219618/hiv-self-testing-in-high-risk-populations
#11
Victoria Frye, Beryl A Koblin
No abstract text is available yet for this article.
February 16, 2017: Lancet HIV
https://www.readbyqxmd.com/read/28219611/integrase-inhibitors-go-head-to-head
#12
Tristan Barber
No abstract text is available yet for this article.
February 14, 2017: Lancet HIV
https://www.readbyqxmd.com/read/28219610/bictegravir-versus-dolutegravir-each-with-emtricitabine-and-tenofovir-alafenamide-for-initial-treatment-of-hiv-1-infection-a-randomised-double-blind-phase-2-trial
#13
Paul E Sax, Edwin DeJesus, Gordon Crofoot, Douglas Ward, Paul Benson, Robin Dretler, Anthony Mills, Cynthia Brinson, Julie Peloquin, Xuelian Wei, Kirsten White, Andrew Cheng, Hal Martin, Erin Quirk
BACKGROUND: All recent treatment guidelines recommend integrase strand transfer inhibitors (INSTIs) as components of initial HIV therapy. Bictegravir, a novel, once-daily, unboosted INSTI, showed potent activity in a 10 day monotherapy study and has a high in-vitro resistance barrier. On the basis of these results, we did a phase 2 trial comparing bictegravir with dolutegravir. METHODS: In this randomised, double-blind, phase 2 trial, we recruited previously untreated adults (aged ≥18 years) with HIV-1 infections from 22 outpatient centres in the USA...
February 14, 2017: Lancet HIV
https://www.readbyqxmd.com/read/28188031/hiv-in-transgender-women-in-brazil
#14
Tonia Poteat, Andrea L Wirtz
No abstract text is available yet for this article.
February 7, 2017: Lancet HIV
https://www.readbyqxmd.com/read/28188030/unveiling-of-hiv-dynamics-among-transgender-women-a-respondent-driven-sampling-study-in-rio-de-janeiro-brazil
#15
Beatriz Grinsztejn, Emilia M Jalil, Laylla Monteiro, Luciane Velasque, Ronaldo I Moreira, Ana Cristina F Garcia, Cristiane V Castro, Alícia Krüger, Paula M Luz, Albert Y Liu, Willi McFarland, Susan Buchbinder, Valdilea G Veloso, Erin C Wilson
BACKGROUND: The burden of HIV in transgender women (transwomen) in Brazil remains unknown. We aimed to estimate HIV prevalence among transwomen in Rio de Janeiro and to identify predictors of newly diagnosed HIV infections. METHODS: We recruited transwomen from Rio de Janeiro, Brazil, by respondent-driven sampling. Eligibility criteria were self-identification as transwomen, being 18 years of age or older, living in Rio de Janeiro or its metropolitan area, and having a valid peer recruitment coupon...
February 7, 2017: Lancet HIV
https://www.readbyqxmd.com/read/28159548/prevalence-and-burden-of-toxoplasma-gondii-infection-in-hiv-infected-people-a-systematic-review-and-meta-analysis
#16
Ze-Dong Wang, Shu-Chao Wang, Huan-Huan Liu, Hong-Yu Ma, Zhong-Yu Li, Feng Wei, Xing-Quan Zhu, Quan Liu
BACKGROUND: Worldwide, 30% of the world's population have antibodies to the intracellular protozoan parasite Toxoplasma gondii and about 36·7 million people are infected with HIV, but little is known about the prevalence of co-infection with T gondii and HIV. We aimed to characterise the epidemiology and burden of T gondii co-infection in people with HIV infection. METHODS: In this systematic review and meta-analysis, we searched PubMed, Embase, Google Scholar, ScienceDirect, Chinese Web of Knowledge, Wanfang, and Chongqing VIP databases for studies reporting T gondii infection in HIV-infected people from inception to Feb 29, 2016...
January 31, 2017: Lancet HIV
https://www.readbyqxmd.com/read/28159547/toxoplasma-gondii-and-hiv-a-never-ending-story
#17
Veeranoot Nissapatorn
No abstract text is available yet for this article.
January 31, 2017: Lancet HIV
https://www.readbyqxmd.com/read/28153471/is-90-90-90-achievable
#18
George W Rutherford, Andrew Anglemyer
No abstract text is available yet for this article.
January 30, 2017: Lancet HIV
https://www.readbyqxmd.com/read/28153470/from-hiv-infection-to-therapeutic-response-a-population-based-longitudinal-hiv-cascade-of-care-study-in-kwazulu-natal-south-africa
#19
Noah Haber, Frank Tanser, Jacob Bor, Kevindra Naidu, Tinofa Mutevedzi, Kobus Herbst, Kholoud Porter, Deenan Pillay, Till Bärnighausen
BACKGROUND: Standard approaches to estimation of losses in the HIV cascade of care are typically cross-sectional and do not include the population stages before linkage to clinical care. We used indiviual-level longitudinal cascade data, transition by transition, including population stages, both to identify the health-system losses in the cascade and to show the differences in inference between standard methods and the longitudinal approach. METHODS: We used non-parametric survival analysis to estimate a longitudinal HIV care cascade for a large population of people with HIV residing in rural KwaZulu-Natal, South Africa...
January 30, 2017: Lancet HIV
https://www.readbyqxmd.com/read/28130027/criminal-law-sex-work-hiv-need-for-multi-level-research
#20
Marie-Claude Boily, Kate Shannon
No abstract text is available yet for this article.
January 24, 2017: Lancet HIV
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