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Lancet HIV

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https://www.readbyqxmd.com/read/28063815/effect-of-immediate-initiation-of-antiretroviral-therapy-on-risk-of-severe-bacterial-infections-in-hiv-positive-people-with-cd4-cell-counts-of-more-than-500-cells-per-%C3%AE-l-secondary-outcome-results-from-a-randomised-controlled-trial
#1
Jemma O'Connor, Michael J Vjecha, Andrew N Phillips, Brian Angus, David Cooper, Beatriz Grinsztejn, Gustavo Lopardo, Satyajit Das, Robin Wood, Aimee Wilkin, Hartwig Klinker, Pacharee Kantipong, Karin L Klingman, David Jilich, Elbushra Herieka, Eileen Denning, Ibrahim Abubakar, Fred Gordin, Jens D Lundgren
BACKGROUND: The effects of antiretroviral therapy on risk of severe bacterial infections in people with high CD4 cell counts have not been well described. In this study, we aimed to quantify the effects of immediate versus deferred ART on the risk of severe bacterial infection in people with high CD4 cell counts in a preplanned analysis of the START trial. METHODS: The START trial was a randomised controlled trial in ART-naive HIV-positive patients with CD4 cell count of more than 500 cells per μL assigned to immediate ART or deferral until their CD4 cell counts were lower than 350 cells per μL...
January 4, 2017: Lancet HIV
https://www.readbyqxmd.com/read/28063814/severe-bacterial-infections-overlooked-opportunistic-diseases
#2
Xavier Anglaret, Serge P Eholie
No abstract text is available yet for this article.
January 4, 2017: Lancet HIV
https://www.readbyqxmd.com/read/27989576/population-levels-and-geographical-distribution-of-hiv-rna-in-rural-ugandan-and-kenyan-communities-including-serodiscordant-couples-a-cross-sectional-analysis
#3
Vivek Jain, Maya L Petersen, Teri Liegler, Dathan M Byonanebye, Dalsone Kwarisiima, Gabriel Chamie, Norton Sang, Doug Black, Tamara D Clark, Andras Ladai, Albert Plenty, Jane Kabami, Emmanuel Ssemmondo, Elizabeth A Bukusi, Craig R Cohen, Edwin D Charlebois, Moses R Kamya, Diane V Havlir
BACKGROUND: As sub-Saharan Africa transitions to a new era of universal antiretroviral therapy (ART), up-to-date assessments of population-level HIV RNA suppression are needed to inform interventions to optimise ART delivery. We sought to measure population viral load metrics to assess viral suppression and characterise demographic groups and geographical locations with high-level detectable viraemia in east Africa. METHODS: The Sustainable East Africa Research in Community Health (SEARCH) study is a cluster-randomised controlled trial of an HIV test-and-treat strategy in 32 rural communities in Uganda and Kenya, selected on the basis of rural setting, having an approximate population of 10 000 people, and being within the catchment area of a President's Emergency Plan for AIDS Relief-supported HIV clinic...
December 15, 2016: Lancet HIV
https://www.readbyqxmd.com/read/27989575/the-holy-grail-of-hiv-programme-effectiveness
#4
Sunil Suhas Solomon
No abstract text is available yet for this article.
December 15, 2016: Lancet HIV
https://www.readbyqxmd.com/read/27956187/trends-in-the-burden-of-hiv-mortality-after-roll-out-of-antiretroviral-therapy-in-kwazulu-natal-south-africa-an-observational-community-cohort-study
#5
Georges Reniers, Sylvia Blom, Clara Calvert, Alexandra Martin-Onraet, Abraham J Herbst, Jeffrey W Eaton, Jacob Bor, Emma Slaymaker, Zehang R Li, Samuel J Clark, Till Bärnighausen, Basia Zaba, Victoria Hosegood
BACKGROUND: Antiretroviral therapy (ART) substantially decreases morbidity and mortality in people living with HIV. In this study, we describe population-level trends in the adult life expectancy and trends in the residual burden of HIV mortality after the roll-out of a public sector ART programme in KwaZulu-Natal, South Africa, one of the populations with the most severe HIV epidemics in the world. METHODS: Data come from the Africa Centre Demographic Information System (ACDIS), an observational community cohort study in the uMkhanyakude district in northern KwaZulu-Natal, South Africa...
December 9, 2016: Lancet HIV
https://www.readbyqxmd.com/read/27956186/life-in-the-time-of-antiretrovirals-in-south-africa
#6
Jennifer Furin, Petros Isaakidis
No abstract text is available yet for this article.
December 9, 2016: Lancet HIV
https://www.readbyqxmd.com/read/27916584/immunological-and-infectious-risk-factors-for-lung-cancer-in-us-veterans-with-hiv-a-longitudinal-cohort-study
#7
Keith Sigel, Juan Wisnivesky, Kristina Crothers, Kirsha Gordon, Sheldon T Brown, David Rimland, Maria C Rodriguez-Barradas, Cynthia Gibert, Matthew Bidwell Goetz, Roger Bedimo, Lesley S Park, Robert Dubrow
BACKGROUND: HIV infection is independently associated with risk of lung cancer, but few data exist for the relation between longitudinal measurements of immune function and lung-cancer risk in people living with HIV. METHODS: We followed up participants with HIV from the Veterans Aging Cohort Study for a minimum of 3 years between Jan 1, 1998, and Dec 31, 2012, and used cancer registry data to identify incident cases of lung cancer. The index date for each patient was the later of the date HIV care began or Jan 1, 1998...
December 1, 2016: Lancet HIV
https://www.readbyqxmd.com/read/27916583/a-novel-marker-of-lung-cancer-risk-in-people-with-hiv
#8
Alain Makinson, Jacques Reynes
No abstract text is available yet for this article.
December 1, 2016: Lancet HIV
https://www.readbyqxmd.com/read/27913227/assisted-partner-services-for-hiv-in-kenya-a-cluster-randomised-controlled-trial
#9
Peter Cherutich, Matthew R Golden, Beatrice Wamuti, Barbra A Richardson, Kristjana H Ásbjörnsdóttir, Felix A Otieno, Ann Ng'ang'a, Peter Maingi Mutiti, Paul Macharia, Betsy Sambai, Matt Dunbar, David Bukusi, Carey Farquhar
BACKGROUND: Assisted partner services for index patients with HIV infections involves elicitation of information about sex partners and contacting them to ensure that they test for HIV and link to care. Assisted partner services are not widely available in Africa. We aimed to establish whether or not assisted partner services increase HIV testing, diagnoses, and linkage to care among sex partners of people with HIV infections in Kenya. METHODS: In this cluster randomised controlled trial, we recruited non-pregnant adults aged at least 18 years with newly or recently diagnosed HIV without a recent history of intimate partner violence who had not yet or had only recently linked to HIV care from 18 HIV testing services clinics in Kenya...
November 29, 2016: Lancet HIV
https://www.readbyqxmd.com/read/27913226/assisted-partner-services-for-hiv-case-finding
#10
Matthew Hogben, Stephanie Behel
No abstract text is available yet for this article.
November 29, 2016: Lancet HIV
https://www.readbyqxmd.com/read/27866873/factors-associated-with-the-uptake-of-and-adherence-to-hiv-pre-exposure-prophylaxis-in-people-who-have-injected-drugs-an-observational-open-label-extension-of-the-bangkok-tenofovir-study
#11
Michael Martin, Suphak Vanichseni, Pravan Suntharasamai, Udomsak Sangkum, Philip A Mock, Benjamaporn Chaipung, Dararat Worrajittanon, Manoj Leethochawalit, Sithisat Chiamwongpaet, Somyot Kittimunkong, Roman J Gvetadze, Janet M McNicholl, Lynn A Paxton, Marcel E Curlin, Timothy H Holtz, Taraz Samandari, Kachit Choopanya
BACKGROUND: Results of the randomised, double-blind, placebo-controlled Bangkok Tenofovir Study (BTS) showed that taking tenofovir daily as pre-exposure prophylaxis (PrEP) can reduce the risk of HIV infection by 49% in people who inject drugs. In an extension to the trial, participants were offered 1 year of open-label tenofovir. We aimed to examine the demographic characteristics, drug use, and risk behaviours associated with participants' uptake of and adherence to PrEP. METHODS: In this observational, open-label extension of the BTS (NCT00119106), non-pregnant, non-breastfeeding, HIV-negative BTS participants, all of whom were current or previous injecting drug users at the time of enrolment in the BTS, were offered daily oral tenofovir (300 mg) for 1 year at 17 Bangkok Metropolitan Administration drug-treatment clinics...
November 17, 2016: Lancet HIV
https://www.readbyqxmd.com/read/27866872/commitment-issues-prep-adherence-in-injecting-drug-users
#12
Kimberly Page, Oliver Bacon
No abstract text is available yet for this article.
November 17, 2016: Lancet HIV
https://www.readbyqxmd.com/read/27863999/assessing-progress-with-hiv-incidence-in-national-cohorts
#13
Salim S Abdool Karim
No abstract text is available yet for this article.
November 15, 2016: Lancet HIV
https://www.readbyqxmd.com/read/27863998/swaziland-hiv-incidence-measurement-survey-shims-a-prospective-national-cohort-study
#14
Jessica Justman, Jason B Reed, George Bicego, Deborah Donnell, Keala Li, Naomi Bock, Alison Koler, Neena M Philip, Charmaine K Mlambo, Bharat S Parekh, Yen T Duong, Dennis L Ellenberger, Wafaa M El-Sadr, Rejoice Nkambule
BACKGROUND: Swaziland has the highest national HIV prevalence worldwide. The Swaziland HIV Incidence Measurement Survey (SHIMS) provides the first national HIV incidence estimate based on prospectively observed HIV seroconversions. METHODS: A two-stage survey sampling design was used to select a nationally representative sample of men and women aged 18-49 years from 14 891 households in 575 enumeration areas in Swaziland, who underwent household-based counselling and rapid HIV testing during 2011...
November 15, 2016: Lancet HIV
https://www.readbyqxmd.com/read/28007345/introducing-optimism-to-models-of-resource-allocation-to-reduce-hiv-incidence-authors-reply
#15
LETTER
Jessica B McGillen, Sarah-Jane Anderson, Timothy B Hallett
No abstract text is available yet for this article.
January 2017: Lancet HIV
https://www.readbyqxmd.com/read/28007344/introducing-optimism-to-models-of-resource-allocation-to-reduce-hiv-incidence
#16
LETTER
Brian G Williams
No abstract text is available yet for this article.
January 2017: Lancet HIV
https://www.readbyqxmd.com/read/28007343/family-planning-for-hiv-positive-girls-and-young-women
#17
Eileen A Yam, Elizabeth Tobey, Amy O Tsui
No abstract text is available yet for this article.
January 2017: Lancet HIV
https://www.readbyqxmd.com/read/28007342/will-president-trump-protect-his-party-s-pepfar-legacy
#18
EDITORIAL
The Lancet Hiv
No abstract text is available yet for this article.
January 2017: Lancet HIV
https://www.readbyqxmd.com/read/28007341/better-late-than-never-prep-in-england
#19
EDITORIAL
The Lancet Hiv
No abstract text is available yet for this article.
January 2017: Lancet HIV
https://www.readbyqxmd.com/read/27914876/phylogenetic-insights-into-age-disparate-partnerships-and-hiv
#20
Mary Kathryn Grabowski, Justin Lessler
No abstract text is available yet for this article.
January 2017: Lancet HIV
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