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Frontiers in Surgery

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https://www.readbyqxmd.com/read/28634582/cancer-stem-cells-in-moderately-differentiated-lip-squamous-cell-carcinoma-express-components-of-the-renin-angiotensin-system
#1
Rachna S Ram, Helen D Brasch, Jonathan C Dunne, Paul F Davis, Swee T Tan, Tinte Itinteang
AIM: We investigated the expression of the renin-angiotensin system (RAS) by cancer stem cell (CSC) subpopulations we have identified in moderately differentiated lip squamous cell carcinoma (MDLSCC). METHOD: Ten MDLSCC samples underwent 3,3-diaminobenzidine (DAB) and immunofluorescent immunohistochemical (IHC) staining for (pro)renin receptor (PRR), angiotensin-converting enzyme (ACE), angiotensin II receptor 1 (ATIIR1), and receptor 2 (ATIIR2). NanoString analysis and Western blotting (WB) were performed on six MDLSCC samples for gene and protein expression, respectively...
2017: Frontiers in Surgery
https://www.readbyqxmd.com/read/28620606/editorial-hip-arthroscopy
#2
EDITORIAL
Shane J Nho, Gift Ukwuani, Joshua D Harris
No abstract text is available yet for this article.
2017: Frontiers in Surgery
https://www.readbyqxmd.com/read/28611989/expression-of-cathepsins-b-d-and-g-in-isocitrate-dehydrogenase-wildtype-glioblastoma
#3
Sabrina P Koh, Agadha C Wickremesekera, Helen D Brasch, Reginald Marsh, Swee T Tan, Tinte Itinteang
AIM: To investigate the expression of cathepsins B, D, and G, in relation to the cancer stem cell (CSC) subpopulations, we have previously characterized within isocitrate dehydogenase (IDH)-wildtype glioblastoma (IDHWGB). METHODS: 3,3-Diaminobezidine (DAB) immunohistochemical (IHC) staining for cathepsins B, D, and G, was performed on 4μm-thick formalin-fixed paraffin-embedded IDHWGB samples obtained from six patients. Two representative DHWGB samples from the original cohort of patients were selected for immunofluorescent (IF) IHC staining, to identify the localization of the cathepsins in relation to the CSC subpopulations...
2017: Frontiers in Surgery
https://www.readbyqxmd.com/read/28611988/management-of-orbital-and-periorbital-venous-malformation
#4
Lara A Benoiton, Kenneth Chan, Frederica Steiner, Trevor FitzJohn, Swee T Tan
BACKGROUND: To review our management of common venous malformation (VM) affecting the orbit and/or periorbital area. METHODS: Consecutive patients with orbital and/or periorbital VM were identified from our vascular anomalies database. Demographic details of the patients, anatomic site(s) affected, symptoms and signs, presence of a family history of VM, and types of treatment(s) were collected, supplemented by chart review. RESULTS: A total of 24 patients' age 1-68 (mean, 30) years with orbital and/or periorbital VM presented with cosmetic concerns (n = 17, 71%), distensibility (n = 15, 63%), pain (n = 9, 38%), diplopia (n = 4, 17%), and spontaneous thrombosis (n = 1, 8%)...
2017: Frontiers in Surgery
https://www.readbyqxmd.com/read/28555187/why-do-parotid-pleomorphic-adenomas-recur-a-systematic-review-of-pathological-and-surgical-variables
#5
REVIEW
Pavel Dulguerov, Jelena Todic, Marc Pusztaszeri, Naif H Alotaibi
BACKGROUND: The recurrence of pleomorphic adenoma (PA) has been extensively debated, mostly in relation to the extent of parotidectomy. METHODS: A systematic review was undertaken to clarify the surgical and pathological variables related to PA recurrence. Inclusion criteria were as follows: English literature, and prospective or retrospective studies. Exclusion criteria were as follows: single case reports, reviews, and lack of PA recurrence data. RESULTS: Pathology-related variables associated with recurrence include the histological subtype, the thickness and incompleteness of the tumor capsule, pseudopodia, and satellite nodules...
2017: Frontiers in Surgery
https://www.readbyqxmd.com/read/28534029/submucosal-inferior-turbinoplasty-using-a-new-continuous-suction-irrigation-method
#6
Takeo Kanaya, Naoyuki Kohno
INTRODUCTION: Numerous surgical techniques for inferior turbinate hypertrophy (ITH) have been reported, each with advantages and disadvantages. Submucosal turbinoplasty with removal of the bony component of the inferior turbinate (IT) is an excellent procedure to expand the nasal cavity. However, this procedure requires a large incision to remove the inferior turbinate bone (ITB) and is associated with hemorrhage, crust formation, and adhesion. A smaller incision would avoid such complications...
2017: Frontiers in Surgery
https://www.readbyqxmd.com/read/28523270/aortic-graft-infection-graphene-shows-the-way-to-an-infection-resistant-vascular-graft
#7
Nikolaos Patelis, Dimitrios Schizas, Theodoros Liakakos, Chris Klonaris
Aortic graft infection is a potentially lethal complication of open and endovascular repair of aortic aneurysms. Graphene is the only existing two-dimensional material, and its unique structure gives graphene and its derivatives a plethora of original characteristics. Among other characteristics, graphene demonstrates bacteriostatic and bactericidal effects that could potentially resolve the problem of graft infection in the future. Data already exist in literature supporting this antibacterial effect of graphene oxide and reduced graphene oxide...
2017: Frontiers in Surgery
https://www.readbyqxmd.com/read/28523269/proximal-aortic-neck-progression-before-and-after-abdominal-aortic-aneurysm-treatment
#8
REVIEW
Konstantinos A Filis, George Galyfos, Fragiska Sigala, Konstantinos Tsioufis, Ioannis Tsagos, Georgios Karantzikos, Christos Bakoyiannis, George Zografos
Several risk factors including short or highly angulated proximal aortic neck have been associated with long-term outcomes after endovascular or open abdominal aortic aneurysm (AAA) repair. However, research data have emerged recently concerning the behavior of proximal aortic neck, and several authors have tried to evaluate this behavior after endovascular or open repair. Additionally, computed tomography angiography (CTA) remains the golden standard for detecting and observing the morphology of an AAA, both before and after treatment...
2017: Frontiers in Surgery
https://www.readbyqxmd.com/read/28507989/diagnostic-laparoscopy-as-decision-tool-for-re-recurrent-inguinal-hernia-treatment-following-open-anterior-and-laparo-endoscopic-posterior-repair
#9
Ferdinand Köckerling, Christine Schug-Pass
INTRODUCTION: The guidelines of the international hernia societies recommend posterior repair in laparo-endoscopic technique for recurrent inguinal hernia after open anterior mesh repair and, conversely, open anterior repair for recurrence after laparo-endoscopic primary repair. Even when these guidelines are followed, already 1 year after repair a re-recurrence rate of 1-2% must be expected, with that rate rising further in the subsequent years. Accordingly, increasingly more patients with re-recurrence after anterior and posterior mesh implantation must be treated, which constitutes a problem that to date has been investigated in only very few studies...
2017: Frontiers in Surgery
https://www.readbyqxmd.com/read/28473974/heart-transplantation-in-a-toddler-with-cardiac-kawasaki-disease
#10
Theodor Tirilomis, Michael Steinmetz, Marius Grossmann, Anselm Bräuer, Thomas Paul, Wolfgang Ruschewski, Friedrich A Schöndube
Kawasaki disease is very rare in Western Europe. The disease may involve coronary arteries. A 2-year-old boy diagnosed with Kawasaki disease had had seizure-like symptoms. Further evaluation revealed recurrent myocardial ischemia and myocardial infarction. Due to extraordinary extension of the coronary disease, myocardial revascularization was not feasible and the toddler underwent successful heart transplantation after 97 days on waiting list.
2017: Frontiers in Surgery
https://www.readbyqxmd.com/read/28443287/brachial-approach-as-an-alternative-technique-of-fibrin-sheath-removal-for-implanted-venous-access-devices
#11
Charalampos Sotiriadis, Steven David Hajdu, Francesco Doenz, Salah D Qanadli
Implanted venous access device (IVAD) late dysfunction is commonly caused by fibrin sheath formation. The standard method of endovascular fibrin sheath removal is performed via the femoral vein. However, it is not always technically feasible and sometimes contraindicated. Moreover, approximately 4-6 h of bed rest is necessary after the procedure. In this article, we describe an alternative method of fibrin sheath removal using the brachial vein approach in a young woman receiving chemotherapy for breast cancer...
2017: Frontiers in Surgery
https://www.readbyqxmd.com/read/28443286/editorial-personalized-medicine-and-neurosurgery
#12
EDITORIAL
M Yashar S Kalani, Nicholas Theodore
No abstract text is available yet for this article.
2017: Frontiers in Surgery
https://www.readbyqxmd.com/read/28443285/high-grade-gliomas-exhibit-higher-peritumoral-fractional-anisotropy-and-lower-mean-diffusivity-than-intracranial-metastases
#13
Kevin S Holly, Benjamin J Barker, Derrick Murcia, Rebekah Bennett, Piyush Kalakoti, Christina Ledbetter, Eduardo Gonzalez-Toledo, Anil Nanda, Hai Sun
Differentiating high-grade gliomas and intracranial metastases through non-invasive imaging has been challenging. Here, we retrospectively compared both intratumoral and peritumoral fractional anisotropy (FA), mean diffusivity (MD), and fluid-attenuated inversion recovery (FLAIR) measurements between high-grade gliomas and metastases. Two methods were utilized to select peritumoral region of interest (ROI). The first method utilized the manual placement of four ROIs adjacent to the lesion. The second method utilized a semiautomated and proprietary MATLAB script to generate an ROI encompassing the entire tumor...
2017: Frontiers in Surgery
https://www.readbyqxmd.com/read/28439517/incidence-and-risk-factors-for-organ-space-infection-after-radiofrequency-assisted-hepatectomy-or-ablation-of-liver-tumors-in-a-single-center-more-than-meets-the-eye
#14
Ioannis Karavokyros, Stamatios Orfanos, Anastasios Angelou, Antonia Meropouli, Dimitrios Schizas, John Griniatsos, Emmanouil Pikoulis
INTRODUCTION: Surgical site infections (SSIs) and especially organ/space infection (O/SI) after resection or ablation of liver tumors are associated with increased morbidity and mortality. A secondary blood stream infection (BSI) is considered an O/SI but the exact prevalence is unknown. We aimed to investigate the incidence of O/SI and BSIs in a cohort of consecutive patients after liver resection or ablation, to seek for a possible connection between them and to search for potential risk factors...
2017: Frontiers in Surgery
https://www.readbyqxmd.com/read/28424776/socially-responsible-surgery-building-recognition-and-coalition
#15
Tyler D Robinson, Thiago M Oliveira, Theresa R Timmes, Jacqueline M Mills, Nichole Starr, Matthew Fleming, Megan Janeway, Diane Haddad, Feroze Sidhwa, Ryan D Macht, Douglas F Kauffman, Tracey A Dechert
IMPORTANCE: Socially responsible surgery (SRS) integrates surgery and public health, providing a framework for research, advocacy, education, and clinical practice to address the social barriers of health that decrease surgical access and worsen surgical outcomes in underserved patient populations. These patients face disparities in both health and in health care, which can be effectively addressed by surgeons in collaboration with allied health professionals. OBJECTIVE: We reviewed the current state of surgical access and outcomes of underserved populations in American rural communities, American urban communities, and in low- and middle-income countries...
2017: Frontiers in Surgery
https://www.readbyqxmd.com/read/28367436/severe-aortic-stenosis-and-severe-coarctation-of-the-aorta-a-hybrid-approach-to-treatment
#16
Daniel McLennan, Massimo Caputo, Demetris Taliotis
Hybrid surgery is becoming more popular in the treatment of children with congenital heart disease, particularly small infants and neonates. We report a case of a patient with aortic stenosis (AS) and coarctation of the aorta (CoA). CASE: a 1-month-old baby presented with severe AS and CoA. The decision was made to perform a hybrid surgical procedure. The patient underwent a lateral thoracotomy for repair of the CoA and carotid cutdown for aortic balloon valvuloplasty (AoVP).
2017: Frontiers in Surgery
https://www.readbyqxmd.com/read/28352629/contained-morcellation-review-of-current-methods-and-future-directions
#17
REVIEW
Enes Taylan, Cagdas Sahin, Burak Zeybek, Ali Akdemir
Power morcellation of surgical specimen during laparoscopic surgery is a practical technology that provides the opportunity to perform several minimally invasive procedures. However, this technology brought forward additional risks and complications associated with dissemination of both benign and malignant tissues inside the abdominal cavity. Based on startling cases, Food and Drug Administration (FDA) announced a discouraging statement on the use of power morcellators that decreased the number of minimally invasive approaches in the following period...
2017: Frontiers in Surgery
https://www.readbyqxmd.com/read/28349051/implementation-of-a-novel-structured-social-and-wellness-committee-in-a-surgical-residency-program-a-case-study
#18
Kathryn E Van Orden, Stephanie D Talutis, Joanna H Ng-Glazier, Aaron P Richman, Elliot C Pennington, Megan G Janeway, Douglas F Kauffman, Tracey A Dechert
This article provides a theoretical and practical rational for the implementation of an innovative and comprehensive social wellness program in a surgical residency program at a large safety net hospital on the East Coast of the United States. Using basic needs theory, we describe why it is particularly important for surgical residency programs to consider the residents sense of competence, autonomy, and belonging during residence. We describe how we have developed a comprehensive program to address our residents' (and residents' families) psychological needs for competence, autonomy, and belongingness...
2017: Frontiers in Surgery
https://www.readbyqxmd.com/read/28321397/the-identification-of-three-cancer-stem-cell-subpopulations-within-moderately-differentiated-lip-squamous-cell-carcinoma
#19
Rachna Ram, Helen D Brasch, Jonathan C Dunne, Paul F Davis, Swee T Tan, Tinte Itinteang
AIM: To identify and characterize cancer stem cells (CSCs) in moderately differentiated lip squamous cell carcinoma (MDLSCC). METHOD: MDLSCC samples underwent 3,3-diaminobenzidine (DAB) immunohistochemical (IHC) staining for squamous cell carcinoma marker EMA, CSC marker CD44 and embryonic stem cell markers NANOG, octamer-binding transcription factor 4 (OCT4), spalt-like transcription factor 4 (SALL4), sex-determining region Y-box 2 (SOX2), and phosphorylated signal transducer and activator of transcription 3 (pSTAT3)...
2017: Frontiers in Surgery
https://www.readbyqxmd.com/read/28321396/popular-hybrid-congenital-heart-procedures-without-cardiopulmonary-bypass
#20
REVIEW
Aamisha Gupta, Zahid Amin
As surgical and catheter interventions advance, patients with congenital heart disease are now offered alternative treatment options that cater to their individual needs. Furthermore, collaboration between interventional cardiologists and cardiac surgeons have led to the development of hybrid procedures, using the best techniques of each respective field to treat these complex cardiac entities from initial treatment in the pediatric patient to repeat intervention in the adult. We present a review of the increased popularity and trend in hybrid procedures in congenital heart disease without the use of cardiopulmonary bypass...
2017: Frontiers in Surgery
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