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BMJ Open Diabetes Research & Care

Vivek Bansal, Adham Mottalib, Taranveer K Pawar, Noormuhammad Abbasakoor, Eunice Chuang, Abrar Chaudhry, Mahmoud Sakr, Robert A Gabbay, Osama Hamdy
Objective: We compared the cost-effectiveness of two inpatient diabetes care models: one offered by a specialized diabetes team (SDT) versus a primary service team (PST). Research design and methods: We retrospectively evaluated 756 hospital admissions of patients with diabetes to non-critical care units over 6 months. Out of 392 patients who met the eligibility criteria, 262 were matched 1:1 based on the mean of the initial four blood glucose (BG) values after admission...
2018: BMJ Open Diabetes Research & Care
Nabil Sulaiman, Ibrahim Mahmoud, Amal Hussein, Salah Elbadawi, Salah Abusnana, Paul Zimmet, Jonathan Shaw
Objective: The objective of this study was to develop a simple non-invasive risk score, specific to the United Arab Emirates (UAE) citizens, to identify individuals at increased risk of having undiagnosed type 2 diabetes mellitus. Research design and methods: A retrospective analysis of the UAE National Diabetes and Lifestyle data was conducted. The data included demographic and anthropometric measurements, and fasting blood glucose. Univariate analyses were used to identify the risk factors for diabetes...
2018: BMJ Open Diabetes Research & Care
Kosuke Robert Shima, Tsuguhito Ota, Ken-Ichiro Kato, Yumie Takeshita, Hirofumi Misu, Shuichi Kaneko, Toshinari Takamura
Objective: We evaluated the effects of ursodeoxycholic acid (UDCA) on glucagon-like peptide-1 (GLP-1) secretion and glucose tolerance in patients with type 2 diabetes with chronic liver disease. Research design and methods: Japanese patients with type 2 diabetes (glycated hemoglobin (HbA1c) levels ≥7.0%) and chronic liver disease were included in this study. Sixteen patients (HbA1c level, 7.2%±0.6%(55.2 mmol/mol)) were randomized to receive 900 mg UDCA for 12 weeks followed by 50 mg sitagliptin add-on therapy for 12 weeks (UDCA-first group; n=8) or 50 mg sitagliptin for 12 weeks followed by 900 mg UDCA add-on therapy for 12 weeks (sitagliptin-first group; n=8)...
2018: BMJ Open Diabetes Research & Care
Zuila Albuquerque Taboza, Katia Linhares Costa, Virginia Régia Silveira, Flavia Aparecida Furlaneto, Renan Montenegro, Stefanie Russell, Ananda Dasanayake, Rodrigo O Rego
Objectives: To compare the glycemic control in non-smoking patients with type 2 diabetes according to their periodontal and dental status. Research design and methods: This cross-sectional study investigated patients previously diagnosed with type 2 diabetes and under antidiabetic medication. Clinical data and fasting blood glucose (FBG) levels were collected from medical and dental records. Patients were divided into three groups according to dental and periodontal diagnosis: no or mild periodontitis (NO/MILD, n=96), moderate or severe periodontitis (MOD/SEV, n=74) and edentulous (n=141)...
2018: BMJ Open Diabetes Research & Care
Gordon P Watt, Susan P Fisher-Hoch, Mohammad H Rahbar, Joseph B McCormick, Miryoung Lee, Audrey C Choh, Sadagopan Thanikachalam, Mohan Thanikachalam
Objective: Prevalence of type 2 diabetes varies by region and ancestry. However, most guidelines for the prevention of diabetes mellitus (DM) are based on European or non-Hispanic white populations. Two ethnic minority populations-Mexican Americans (MAs) in Texas, USA, and South Indians (SIs) in Tamil Nadu, India-have an increasing prevalence of DM. We aimed to understand the metabolic correlates of DM in these populations to improve risk stratification and DM prevention. Research design and methods: The Cameron County Hispanic Cohort (CCHC; n=3023) served as the MA sample, and the Population Study of Urban, Rural, and Semi-Urban Regions for the Detection of Endovascular Disease (PURSE; n=8080) served as the SI sample...
2018: BMJ Open Diabetes Research & Care
Nestoras Nicolas Mathioudakis, Estelle Everett, Shuvodra Routh, Peter J Pronovost, Hsin-Chieh Yeh, Sherita Hill Golden, Suchi Saria
Objective: To develop and validate a multivariable prediction model for insulin-associated hypoglycemia in non-critically ill hospitalized adults. Research design and methods: We collected pharmacologic, demographic, laboratory, and diagnostic data from 128 657 inpatient days in which at least 1 unit of subcutaneous insulin was administered in the absence of intravenous insulin, total parenteral nutrition, or insulin pump use (index days). These data were used to develop multivariable prediction models for biochemical and clinically significant hypoglycemia (blood glucose (BG) of ≤70 mg/dL and <54 mg/dL, respectively) occurring within 24 hours of the index day...
2018: BMJ Open Diabetes Research & Care
Satomi Minato, Kaori Kitaoka, Mika Takeuchi, Ayaka Tsuboi, Miki Kurata, Shigehiro Tanaka, Tsutomu Kazumi, Keisuke Fukuo
Objective: We test the hypothesis that aspartate aminotransferase (AST) may be associated inversely with serum triglycerides (TG) and positively with high density lipoprotein (HDL) cholesterol in young athletes because athletes have larger amounts of muscle mass. Research design and methods: Pearson's correlation coefficients were calculated between serum AST and alanine aminotransferase (ALT) and body composition identified by dual-energy X-ray absorptiometry, markers of insulin resistance, serum lipids, lipoproteins, apolipoproteins, adiponectin and leptin in 174 female collegiate athletes (18-22 years)...
2018: BMJ Open Diabetes Research & Care
Roger Chafe, Rana Aslanov, Atanu Sarkar, Peter Gregory, Alex Comeau, Leigh Anne Newhook
Objective: To determine the association between drinking water quality and rates of type 1 diabetes in the Newfoundland and Labrador (NL) population, which has one of the highest incidences of type 1 diabetes reported globally. Research design and methods: The study used a community-based, case-control design. We first calculated incidence rates of type 1 diabetes at the provincial, regional and community levels. The connection between incidence rates and components in public water supplies were then analyzed in three ways: to evaluate differences in water quality between communities with and without incident cases of type 1 diabetes, and to analyze the relationship between water quality and incidence rates of type 1 diabetes at both the community and regional levels...
2018: BMJ Open Diabetes Research & Care
Sofia Dahlqvist, Elsa Ahlén, Karin Filipsson, Thomas Gustafsson, Irl B Hirsch, Jaakko Tuomilehto, Henrik Imberg, Bo Ahrén, Stig Attvall, Marcus Lind
Objective: To evaluate variables associated with hemoglobin A1c (HbA1c) and weight reduction when adding liraglutide to persons with type 2 diabetes treated with multiple daily insulin injections (MDI). Research design and methods: This was a reanalysis of a previous trial where 124 patients were enrolled in a double-blind, placebo-controlled, multicenter randomized trial carried out over 24 weeks. Predictors for effect on change in HbA1c and weight were analyzed within the treatment group and with concurrent interaction analyses...
2018: BMJ Open Diabetes Research & Care
Katrin E Schimke, Frida Renström, Sandro Meier, Christoph Stettler, Michael Brändle
Objective: Tight glycemic control and aggressive treatment of additional cardiovascular risk factors can substantially reduce risk of diabetes-related complications. In 2013, the Swiss Society of Endocrinology and Diabetology (SSED) established national criteria on good disease management in diabetes, but little is known about compliance in clinical care. Here we assessed to what extent patients from two tertiary care centers in the German-speaking part of Switzerland enrolled in the Swiss Diabetes (SwissDiab) Registry adhere to the SSED criteria...
2018: BMJ Open Diabetes Research & Care
Fitsum Eyayu Tarekegne, Mojgan Padyab, Julia Schröders, Jennifer Stewart Williams
Objective: The objective is to identify and describe the sociodemographic and behavioral characteristics of adults, aged 50 years and over, who self-reported having been diagnosed and treated for diabetes mellitus (DM) in Ghana and South Africa. Research design and methods: This is a cross-sectional study based on the WHO Study on global AGEing and adult health (SAGE) wave 1. Information on sociodemographic factors, health states, risk factors and chronic conditions is captured from questionnaires administered in face-to-face interviews...
2018: BMJ Open Diabetes Research & Care
Sarah S Casagrande, Daniela Sotres-Alvarez, Larissa Avilés-Santa, Matthew J O'Brien, Cristina Palacios, Cynthia M Pérez, Samantha A Reina, Xueyin Wang, Qibin Qi, Aida L Giachello, Rebeca A Espinoza Giacinto, Catherine C Cowie
Objective: A healthy diet is important for diabetes prevention and control; however, few studies have assessed dietary intake among US Hispanics/Latinos, a diverse population with a significant burden of diabetes. To address this gap in the literature, we determined intake of energy, macro/micronutrients, and vitamin supplements among Hispanics/Latinos by glycemic status and heritage. Research design and methods: Cross-sectional study of adults aged 18-74 years from the Hispanic Community Health Study/Study of Latinos (2008-2011) with complete baseline data on glycemic status and two 24-hour dietary recalls (n=13 089)...
2018: BMJ Open Diabetes Research & Care
Gian Paolo Fadini, Mayur Sarangdhar, Angelo Avogaro
Objectives: Glucagon-like peptide-1 receptor agonists (GLP-1RA) are widely used for the treatment of type 2 diabetes. In large trials, the GLP-1RAs liraglutide and semaglutide improved cardiovascular outcomes, but semaglutide was associated with an increased risk of retinopathy progression. We herein evaluated the association between GLP-1RA and retinal adverse events (AE) in the Food and Drug Administration Adverse Event Reporting System (FAERS). Research design and methods: We mined the FAERS between 2004q1 and 2017q1 (for a total of 9 217 555 AE reports) to analyze disproportionality and evaluate the association between GLP-1RAs and AEs involving the retina...
2018: BMJ Open Diabetes Research & Care
Naseer Ahmed, Yong Choe, Vikkie A Mustad, Sumita Chakraborty, Scott Goates, Menghua Luo, Jeffrey I Mechanick
Objective: The aim of this study was to examine the impact of pre-existing malnutrition on survival and economic implications in elderly patients with diabetes. Research design and methods: A retrospective observational study was conducted to examine the impact of malnutrition with or without other significant health conditions on survival time and healthcare costs using the Centers for Medicare and Medicaid Services (CMS) data from 1999 to 2014 for beneficiaries with a confirmed first date of initial diagnosis of diabetes (n=15 121 131)...
2018: BMJ Open Diabetes Research & Care
Linda S Geiss, Kai McKeever Bullard, Ralph Brinks, Annika Hoyer, Edward W Gregg
Objective: To examine recent trends in type 2 diabetes detection among adults in the USA. Research design and methods: We used data from the 1999-2014 National Health and Nutrition Examination Surveys on non-pregnant adults (aged ≥18 years) not reporting a diagnosis of diabetes (n=16 644 participants, averaging about 2000 for each 2-year cycle). We defined undiagnosed diabetes as a fasting plasma glucose ≥126 mg/dL or a hemoglobin A1c ≥6.5% (48 mmol/mol)...
2018: BMJ Open Diabetes Research & Care
Helen Strongman, Solomon Christopher, Maila Majak, Rachael Williams, Shahram Bahmanyar, Marie Linder, Edith M Heintjes, Dimitri Bennett, Pasi Korhonen, Fabian Hoti
Objectives: Describe and compare the risk of cardiovascular and non-cardiovascular mortality in patients whose antidiabetic therapy is modified to include pioglitazone compared with an alternative antidiabetic medication at the same stage of disease progression. Research design and methods: This exploratory linked database cohort analysis used pooled health and mortality data from three European countries: Finland, Sweden and the UK. Propensity score together with exact matching was used to match 31 133 patients with type 2 diabetes first prescribed pioglitazone from 2000 to 2011, to 31 133 patients never prescribed pioglitazone...
2018: BMJ Open Diabetes Research & Care
(no author information available yet)
[This corrects the article DOI: 10.1136/bmjdrc-2017-000451.][This corrects the article DOI: 10.1136/bmjdrc-2017-000451.].
2017: BMJ Open Diabetes Research & Care
Susanne Röckl, Ralph Brinks, Jens Baumert, Rebecca Paprott, Yong Du, Christin Heidemann, Christa Scheidt-Nave
Objective: To estimate age-specific and sex-specific all-cause mortality among adults with and without type 2 diabetes (T2D) in Germany. Research design and methods: The German National Health Interview and Examination Survey 1998 (GNHIES98) included a mortality follow-up (median follow-up time 12.0 years) of its nationwide sample representative of the population aged 18-79 years. After exclusion of participants with type 1 diabetes, age- and sex-stratified mortality rates (MR) were calculated for 330 GNHIES98 participants with diagnosed T2D (self-reported diagnosis or antidiabetic medication), 245 with undiagnosed T2D (no diagnosed T2D, glycated hemoglobin A1c ≥6...
2017: BMJ Open Diabetes Research & Care
Sonja M Reichert, Stewart B Harris, Jordan W Tompkins, Judith Belle-Brown, Meghan Fournie, Michael Green, Han Han, Jyoti Kotecha, Selam Mequanint, Jann Paquette-Warren, Sharon Roberts, Grant Russell, Moira Stewart, Amardeep Thind, Susan Webster-Bogaert, Richard Birtwhistle
Objective: Primary healthcare (PHC) quality improvement (QI) initiatives are designed to improve patient care and health outcomes. We evaluated the Quality Improvement and Innovation Partnership (QIIP), an Ontario-wide PHC QI program on access to care, diabetes management and colorectal cancer screening. This manuscript highlights the impact of QIIP on diabetes outcomes and associated vascular risk factors. Research design and methods: A cluster matched-control, retrospective prechart and postchart audit was conducted...
2017: BMJ Open Diabetes Research & Care
Winnie S S Chee, Harvinder Kaur Gilcharan Singh, Osama Hamdy, Jeffrey I Mechanick, Verna K M Lee, Ankur Barua, Siti Zubaidah Mohd Ali, Zanariah Hussein
Objective: Trans-cultural diabetes nutrition algorithm (tDNA) was created by international task force and culturally customized for Malaysian population. This study was designed to evaluate its effectiveness versus usual diabetes care in primary care settings. Research design and methods: We randomized 230 patients with overweight/obesity, type 2 diabetes, and glycated hemoglobin (A1c) 7%-11% to receive usual care (UC) or UC with tDNA for 6 months. The tDNA intervention consisted of structured low-calorie meal plan, diabetes-specific meal replacements, and increased physical activity...
2017: BMJ Open Diabetes Research & Care
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