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BMJ Open Diabetes Research & Care

Thomas H Wieringa, Maartje de Wit, Jos Wr Twisk, Frank J Snoek
Objective: Insulin glargine 300 (Gla-300) provides less hypoglycemia risk and more flexibility in injection time. The extent to which these effects translate into improved patient-reported outcomes (PROs) is unknown, and is the subject of this observational study. Research design and methods: Adults with type 2 diabetes treated with basal insulin for at least 6 months initiating Gla-300 were included. Data were collected at baseline (start Gla-300) and at 3-month and 6-month follow-up...
2018: BMJ Open Diabetes Research & Care
Dawn Cameron, Fiona Harris, Josie M M Evans
Objective: To explore how and why self-monitoring of blood glucose (SMBG) is carried out in a real-world context. Research design and methods: We conducted a multicase study among ten people with type 1 and insulin-treated type 2 diabetes mellitus in Scotland, alongside seven nominated support people and four healthcare professionals. All participants were interviewed in depth and six participants provided SMBG diaries. Stones' version of structuration theory informed the analysis...
2018: BMJ Open Diabetes Research & Care
Rachel G Tabak, Renee G Parks, Peg Allen, Rebekah R Jacob, Stephanie Mazzucca, Katherine A Stamatakis, Allison R Poehler, Marshall H Chin, Maureen Dobbins, Debra Dekker, Ross C Brownson
Objective: The nearly 3000 local health departments (LHDs) nationwide are the front line of public health and are positioned to implement evidence-based interventions (EBIs) for diabetes control. Yet little is currently known about use of diabetes-related EBIs among LHDs. This study used a national online survey to determine the patterns and correlates of the Centers for Disease Control and Prevention Community Guide-recommended EBIs for diabetes control in LHDs. Research design and methods: A cross-sectional study was conducted to survey a stratified random sample of LHDs regarding department characteristics, respondent characteristics, evidence-based decision making within the LHD, and delivery of EBIs (directly or in collaboration) within five categories (diabetes-related, nutrition, physical activity, obesity, and tobacco)...
2018: BMJ Open Diabetes Research & Care
Sadia Mehmood, Myles Margolis, Chang Ye, Louise Maple-Brown, Anthony J Hanley, Philip W Connelly, Mathew Sermer, Bernard Zinman, Ravi Retnakaran
Objective: Women with a history of gestational diabetes mellitus (GDM) have an elevated risk of ultimately developing pre-diabetes and diabetes later in life. They also have an increased prevalence of fatty liver, but recent studies have reported conflicting findings on whether hepatic fat affects their risk of pre-diabetes/diabetes. Thus, we sought to evaluate the associations of liver fat with glucose homeostasis and determinants thereof in women with and without recent gestational dysglycemia...
2018: BMJ Open Diabetes Research & Care
Mika Takeuchi, Ayaka Tsuboi, Satomi Minato, Megumu Yano, Kaori Kitaoka, Miki Kurata, Tsutomu Kazumi, Keisuke Fukuo
Objective: To determine if adiponectin levels are associated with low grip strength among the elderly independently of insulin resistance and inflammation. Research design and methods: Cross-sectional associations were analyzed by logistic regression between low grip strength and body composition, elevated serum adiponectin (≥20 mg/L), and biomarkers of nutritious stasis, insulin resistance and inflammation in 179 community-living Japanese women. Sarcopenia was evaluated using the Asian criteria...
2018: BMJ Open Diabetes Research & Care
Mahmoud Ibrahim, Sulaf I Abdelaziz, Megahed Abu Almagd, Monira Alarouj, Firas A Annabi, David G Armstrong, Ebtesam Ba-Essa, Abdullah Ben Nakhi, Nadia Boudjenah, Amy Hess Fischl, Al Ghomari Hassan, Shabeen Naz Masood, Aly A Misha'l, A Samad Shera, Jaakko Tuomilehto, Guillermo E Umpierrez
Hajj is one of the five pillars of Islam and is a must-do for all adult Muslims once in their life provided they are able to do it. Considering the 8.8% global prevalence of diabetes, coupled with the number of Muslims performing Hajj (~2.5 million adult Muslims), it could be estimated that Muslims with diabetes performing Hajj may exceed 220 000 per year. According to Islamic rules, Hajj should not cause severe difficulties for Muslims. The Holy Qur'an specifically exempts from this duty Muslims who are unable physically or financially if it might lead to harmful consequences for the individual...
2018: BMJ Open Diabetes Research & Care
Lisa S Chow, Rachel Zmora, Sisi Ma, Elizabeth R Seaquist, Pamela J Schreiner
Objective: We constructed a predictive model of long-term risk for severe hypoglycemia (SH: hypoglycemia requiring assistance) in patients with type 2 diabetes (T2DM). Research design and methods: Data from the Action to Control Cardiovascular Risk in Diabetes (ACCORD) study (original n=10 251, n=5135 used in the current analysis), a randomized, multicenter, double 2×2 factorial design study examining the effect of glycemic, blood pressure, and lipid control on cardiovascular outcomes in patients with diagnosed T2DM, were used...
2018: BMJ Open Diabetes Research & Care
Melissa Burroughs Peña, Katrina Swett, Neil Schneiderman, Daniel M Spevack, Sonia G Ponce, Gregory A Talavera, Mayank M Kansal, Martha L Daviglus, Jianwen Cai, Barry E Hurwitz, Maria M Llabre, Carlos J Rodriguez
Objective: We assessed the hypothesis that metabolic syndrome is associated with adverse changes in cardiac structure and function in participants of the Echocardiographic Study of Latinos (Echo-SOL). Methods: Non-diabetic Echo-SOL participants were included in this cross-sectional analysis. Metabolic syndrome was defined according to the American Heart Association/National Heart, Lung, and Blood Institute 2009 Joint Scientific Statement. Survey multivariable linear regression analyses using sampling weights were used adjusting for multiple potential confounding variables...
2018: BMJ Open Diabetes Research & Care
Aleksandra M Zuk, Carlos R Quiñonez, Olli Saarela, Ryan T Demmer, Laura C Rosella
Objective: Periodontitis is strongly associated with diabetes and is increasingly shown to be associated with other glycemic abnormalities. Vitamin D is postulated to have both anti-inflammatory and antimicrobial activity. Therefore, our aim was to investigate the joint effects of both serum 25-hydroxyvitamin D3 and total 25-hydroxyvitamin D with periodontitis on homeostatic model assessment for insulin resistance (HOMA-IR), pre-diabetes, and type 2 diabetes. Research design and methods: Using data from the 2009-2010 National Health and Nutrition Examination Survey, the sample was restricted to adults over 30 years of age, who were eligible for oral health examination, and had vitamin D, fasting glucose and insulin measures...
2018: BMJ Open Diabetes Research & Care
William E Kraus, Thomas Yates, Jaakko Tuomilehto, Jie-Lena Sun, Laine Thomas, John J V McMurray, M Angelyn Bethel, Rury R Holman
Objective: Physical activity is related to clinical outcomes, even after adjusting for body mass, but is rarely assessed in randomized clinical trials. Research design and methods: We conducted an observational analysis of data from the Nateglinide and Valsartan in Impaired Glucose Tolerance Outcomes Research trial, in which a total of 9306 people from 40 countries with impaired glucose tolerance and either cardiovascular disease or cardiovascular risk factors were randomized to receive nateglinide or placebo, in a 2-by-2 factorial design with valsartan or placebo...
2018: BMJ Open Diabetes Research & Care
Abdulqawi Al Mansari, Youssef Obeid, Najmul Islam, Mohammed Fariduddin, Ahmed Hassoun, Khier Djaballah, Mojtaba Malek, Dror Dicker, Tirthankar Chaudhury
Objective: The American Diabetes Association and the European Association for the Study of Diabetes guidelines recommend to individualize treatment targets/strategies in inadequately controlled patients by lifestyle management and glucose-lowering drugs to decrease the burden of diabetes-related complications. This real-world practice study aimed to assess predictive factors for achieving the glycemic hemoglobin A1c (HbA1c) at 6 months as targeted by the treating physician in adults with type 2 diabetes who required initiation of basal insulin, initiation of bolus insulin, or modification from basal or premixed insulin to new insulin regimen containing insulin glargine and/or insulin glulisine...
2018: BMJ Open Diabetes Research & Care
(no author information available yet)
[This corrects the article DOI: 10.1136/bmjdrc-2018-000531.].
2018: BMJ Open Diabetes Research & Care
Kristin Mühlenbruch, Rebecca Paprott, Hans-Georg Joost, Heiner Boeing, Christin Heidemann, Matthias B Schulze
Objective: The German Diabetes Risk Score (GDRS) is a diabetes prediction model which only includes non-invasively measured risk factors. The aim of this study was to extend the original GDRS by hemoglobin A1c (HbA1c) and validate this clinical GDRS in the nationwide German National Health Interview and Examination Survey 1998 (GNHIES98) cohort. Research design and methods: Extension of the GDRS was based on the European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam study with baseline assessment conducted between 1994 and 1998 (N=27 548, main age range 35-65 years)...
2018: BMJ Open Diabetes Research & Care
Frances Wensley, Christopher Kerry, Gerry Rayman
Aims: Diabetes increases the risk of costly and potentially preventable hospital-acquired pressure ulceration. Given that peripheral arterial disease and neuropathy, important risk factors for foot ulceration, are more common in people with diabetes, their risk of hospital-acquired foot ulceration (HAFU) in particular may be even greater. This study aims to determine this risk. Methods: Using data collected over 2 years from all admissions to the Ipswich Hospital NHS Trust, we conducted a prospective multilevel regression analysis of the risk of HAFU in 5043 admissions of people with diabetes versus 23 599 without diabetes...
2018: BMJ Open Diabetes Research & Care
Mahée Gilbert-Ouimet, Huiting Ma, Rick Glazier, Chantal Brisson, Cameron Mustard, Peter M Smith
Objective: According to the International Diabetes Federation, the most important challenge for prevention is now to identify social and environmental modifiable risk factors of diabetes. In this regard, long work hours have recently been linked with diabetes, but more high-quality prospective studies are needed. We evaluated the relationship between long work hours and the incidence of diabetes among 7065 workers over a 12-year period in Ontario, Canada. Research design and methods: Data from Ontario respondents (35-74 years of age) to the 2003 Canadian Community Health Survey were prospectively linked to the Ontario Health Insurance Plan database for physician services and the Canadian Institute for Health Information Discharge Abstract Database for hospital admissions...
2018: BMJ Open Diabetes Research & Care
Russell Drummond, Ankita Baru, Marcelina Dutkiewicz, Amaury Basse, Bengt-Olov Tengmark
Objective: This study aimed to build on the current clinical findings and investigate physicians' experiences and level of satisfaction in using insulin degludec/liraglutide (IDegLira) to treat patients with type 2 diabetes (T2D). Research design and methods: This multicountry, European online survey included respondents from primary (n=132) and secondary (n=103) care and examined physicians' use, confidence and satisfaction with IDegLira. To standardize responses, 24 of 28 questions pertained to an 'average patient' with T2D who has no major comorbidities, aged 35-70 years, with average cognitive ability/normal mental status and body mass index ≥25 kg/m2 ...
2018: BMJ Open Diabetes Research & Care
Giacomo Zoppini, Corinna Bergamini, Stefano Bonapace, Maddalena Trombetta, Alessandro Mantovani, Anna Toffalini, Laura Lanzoni, Lorenzo Bertolini, Luciano Zenari, Enzo Bonora, Giovanni Targher, Andrea Rossi
Background: Type 2 diabetes may alter cardiac structure and function. Many patients with type 2 diabetes have diastolic dysfunction with preserved ejection fraction (EF). Recently, this latter measure was criticised. Thus, this research looked at the impact of left ventricular end-diastolic volume and E/e' ratio variations in patients with type 2 diabetes and preserved EF with the aim to recognise different clinical phenotypes. Methods: In this cross-sectional study, we evaluated 176 men affected by type 2 diabetes with transthoracic echocardiography...
2018: BMJ Open Diabetes Research & Care
Sridharan Raghavan, Wenhui G Liu, David R Saxon, Gary K Grunwald, Thomas M Maddox, Jane E B Reusch, Seth A Berkowitz, Liron Caplan
Objective: To determine whether sulfonylurea use, compared with non-sulfonylurea oral diabetes medication use, was associated with 2-year mortality in individuals with well-controlled diabetes and coronary artery disease (CAD). Research design and methods: We studied 5352 US veterans with type 2 diabetes, obstructive CAD on coronary angiography, hemoglobin A1c ≤7.5% at the time of catheterization, and taking zero or one oral diabetes medication (categorized as no medications, non-sulfonylurea medication, or sulfonylurea)...
2018: BMJ Open Diabetes Research & Care
Surya Prakash Bhatt, Anoop Misra, Seema Gulati, Naamrata Singh, Ravindra Mohan Pandey
Background: Asian Indian women are predisposed to develop obesity, metabolic syndrome and vitamin D deficiency. Relationship of vitamin D deficiency with blood glucose levels has not been explored in Asian Indian women with pre-diabetes. Objective: We evaluated the associations of serum 25-hydroxy vitamin D (25(OH)D) concentrations among adult women with the pre-diabetes residing in North India (Delhi). Methods: This cross-sectional population-based study involved 797 women with pre-diabetes aged 20-60 years...
2018: BMJ Open Diabetes Research & Care
Faith Agbozo, Abdulai Abubakari, Clement Narh, Albrecht Jahn
Objective: Despite the short-term and long-term health implications of gestational diabetes mellitus (GDM), opinions are divided on selective vis-à-vis universal screening. We validated the accuracy of screening tests for GDM. Research design and methods: Pregnant women (n=491) were recruited to this prospective, blind comparison with a gold standard study. We did selective screening between 13 and 20 weeks using reagent-strip glycosuria, random capillary blood glucose (RBG) and the presence of ≥1 risk factor(s)...
2018: BMJ Open Diabetes Research & Care
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