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BMJ Open Diabetes Research & Care

Dmitry Kats, A Richey Sharrett, Henry N Ginsberg, Vijay Nambi, Christie M Ballantyne, Ron C Hoogeveen, Gerardo Heiss
OBJECTIVE: Excessive levels of triglyceride-rich lipoproteins during postprandial lipemia (PPL) have been reported to be atherogenic. However, it is unclear whether the degree of PPL independently predicts cardiovascular disease (CVD) given the scarcity of longitudinal data with standardised measures of postprandial change. We reexamined associations of PPL with incident CVD events in a population-based cohort using detailed measures of postprandial change from a standardised fat challenge...
2017: BMJ Open Diabetes Research & Care
Alfonso C Hernandez-Romieu, Shikha Garg, Eli S Rosenberg, Angela M Thompson-Paul, Jacek Skarbinski
BACKGROUND: Nationally representative estimates of diabetes mellitus (DM) prevalence among HIV-infected adults in the USA are lacking, and whether HIV-infected adults are at increased risk of DM compared with the general adult population remains controversial. METHODS: We used nationally representative survey (2009-2010) data from the Medical Monitoring Project (n=8610 HIV-infected adults) and the National Health and Nutrition Examination Survey (n=5604 general population adults) and fit logistic regression models to determine and compare weighted prevalences of DM between the two populations, and examine factors associated with DM among HIV-infected adults...
2017: BMJ Open Diabetes Research & Care
Wenjun Fan, Debora H Lee, John Billimek, Sarah Choi, Ping H Wang
OBJECTIVE: The prevalence of diabetes mellitus (DM) is increasing rapidly, particularly in Asia. Asian immigrants in Western countries are a fast-growing population who carry both intrinsic risks due to their genetic background and extrinsic risks associated with Western lifestyles. However, recent trends in diabetes prevalence and associated risk factors among Asian immigrants in the USA are not well understood. RESEARCH DESIGN AND METHODS: We examined adults aged 18 and older from the recent California Health Interview Survey data sets from 2003 to 2013 to determine prevalence of known DM among first-generation Asian immigrants and whites...
2017: BMJ Open Diabetes Research & Care
Peter Bramlage, Tobias Bluhmki, Holger Fleischmann, Matthias Kaltheuner, Jan Beyersmann, Reinhard W Holl, Thomas Danne
OBJECTIVE: We aimed to describe patterns of weight change in insulin-naive patients with type 2 diabetes mellitus (T2DM) starting basal insulin (BI) treatment. RESEARCH DESIGN AND METHODS: Diabetes Versorgungs-Evaluation (DIVE) is an observational, multicenter, prospective registry in patients with T2DM. Patients were divided into those initiating BI therapy for the first time (with optional oral antidiabetic drugs (OADs)) and those initiating OADs only (OADo). RESULTS: 521 patients were included in the analysis, 113 in the BI arm and 408 in the OADo arm...
2017: BMJ Open Diabetes Research & Care
Juan J Gagliardino, Petar K Atanasov, Juliana C N Chan, Jean C Mbanya, Marina V Shestakova, Prisca Leguet-Dinville, Lieven Annemans
OBJECTIVE: Type 2 diabetes (T2D) and its complications form a global healthcare burden but the exact impact in some geographical regions is still not well documented. We describe the healthcare resource usage (HRU) associated with T2D in Africa, the Middle East, South Asia, Eurasia and Turkey. RESEARCH DESIGN AND METHODS: In the fifth wave of the International Diabetes Management Practices Study (IDMPS; 2011-2012), we collected self-reported and physician-reported cross-sectional data from 8156 patients from 18 countries across 5 regions, including different types of HRU in the previous 3-6 months...
2017: BMJ Open Diabetes Research & Care
Sarah-Jo Sinnott, Sheena McHugh, Helen Whelton, Richard Layte, Steve Barron, Patricia M Kearney
OBJECTIVE: To estimate the prevalence and incidence of type 2 diabetes using a national pharmacy claims database. RESEARCH DESIGN AND METHODS: We used data from the Health Service Executive-Primary Care Reimbursement Service database in Ireland for this cross-sectional study. Prevalent cases of type 2 diabetes were individuals using an oral hypoglycemic agent, irrespective of insulin use, in 2012. Incident cases were individuals using an oral hypoglycemic agent in 2012 who had not used one in the past...
2017: BMJ Open Diabetes Research & Care
Maryse C J Osté, Eva Corpeleijn, Gerjan J Navis, Charlotte A Keyzer, Sabita S Soedamah-Muthu, Else van den Berg, Douwe Postmus, Martin H de Borst, Daan Kromhout, Stephan J L Bakker
OBJECTIVE: The incidence of new-onset diabetes after transplantation (NODAT) and premature mortality is high in renal transplant recipients (RTR). We hypothesized that a Mediterranean Style diet protects against NODAT and premature mortality in RTR. RESEARCH DESIGN AND METHODS: A prospective cohort study of adult RTR with a functioning graft for >1 year. Dietary intake was assessed with a 177-item validated food frequency questionnaire. Patients were divided based on a 9-point Mediterranean Style Diet Score (MDS): low MDS (0-4 points) versus high MDS (5-9 points)...
2017: BMJ Open Diabetes Research & Care
Ankica Markoska, Rajalakshmi Valaiyapathi, Chloe Thorn, Anne Dornhorst
HYPOTHESIS: In pregnancy, urinary C peptide creatinine ratio (UCPCR) reflects endogenous insulin secretion in women with normal glucose tolerance and type 1 diabetes. RESEARCH DESIGN AND METHODS: UCPCR and serum C peptide were measured in 90 glucose-tolerant women at 0 and 120 min during a 75 g oral glucose tolerance test (OGTT) at 28 weeks of gestation. UCPCR was measured in 2 samples obtained over 10 weeks apart in 7 pregnant women with longstanding type 1 diabetes...
2017: BMJ Open Diabetes Research & Care
Osama Hamdy, Adham Mottalib, Amr Morsi, Nuha El-Sayed, Ann Goebel-Fabbri, Gillian Arathuzik, Jacqueline Shahar, Amanda Kirpitch, John Zrebiec
OBJECTIVE: We evaluated long-term impact of sustained weight loss versus weight regain on cardiovascular risk factors in real-world clinical practice. METHODS: We evaluated 129 obese patients with diabetes enrolled in Weight Achievement and Intensive Treatment (Why WAIT) program, a 12-week clinical model of intensive lifestyle intervention. After 1 year, we divided participants into group A, who maintained <7% weight loss (47.3%) and group B (52.7%), who maintained ≥7% weight loss...
2017: BMJ Open Diabetes Research & Care
Carla Assaf-Balut, Cristina Familiar, Nuria García de la Torre, Miguel A Rubio, Elena Bordiú, Laura Del Valle, Miriam Lara, Teresa Ruiz, Ana Ortolá, Irene Crespo, Alejandra Duran, Miguel A Herraiz, Nuria Izquierdo, Noelia Perez, Maria J Torrejon, Isabelle Runkle, Carmen Montañez, Alfonso L Calle-Pascual
BACKGROUND: Obesity and gestational diabetes mellitus (GDM) increase the morbidity of the mother and newborn, which could increase further should they coexist. We aimed to determine the risk of adverse pregnancy and neonatal outcomes associated with excess weight (EW), and within this group identify potential differences between those with and without GDM. METHODS: We carried out a post-hoc analysis of the St. Carlos Gestational Study which included 3312 pregnant women, arranged in 3 groups: normal-weight women (NWw) (2398/72...
2016: BMJ Open Diabetes Research & Care
Keiko Takasaki, Tetsuya Babazono, Kaya Ishizawa, Junnosuke Miura, Yasuko Uchigata
OBJECTIVE: We conducted this cross-sectional study to investigate the relationship between stage of diabetic nephropathy and likelihood or severity of depression in patients with diabetes. RESEARCH DESIGN AND METHODS: We studied 2212 patients with diabetes (mean age 60.9 years; 928 women; 1838 patients with type 2 diabetes). Presence and severity of depression was examined using the Patient Health Questionnaire-9 (PHQ-9). Patients were classified into 5 stages of nephropathy, according to albuminuria and estimated glomerular filtration rate (eGFR); patients in stage 5 undergoing dialysis and kidney transplantation were analyzed separately (stages 5D and 5T)...
2016: BMJ Open Diabetes Research & Care
Naomi Boxall, Dimitri Bennett, Matthias Hunger, Paul Dolin, Paula L Thompson
OBJECTIVES: Investigate potential association between pioglitazone exposure and risk of prostate cancer. RESEARCH DESIGN AND METHODS: Nested, matched case-control study. UK primary care data (Clinical Practice Research Datalink (CPRD) GOLD) linked to inpatient (Hospital Episode Statistics (HES)) and cancer registry (National Cancer Information Network (NCIN)) data. English men aged ≥40 years diagnosed with type 2 diabetes mellitus, January 1, 2001 to January 5, 2015...
2016: BMJ Open Diabetes Research & Care
Min-Woong Sohn, Hyojung Kang, Joseph S Park, Paul Yates, Anthony McCall, George Stukenborg, Roger Anderson, Rajesh Balkrishnan, Jennifer M Lobo
OBJECTIVE: To examine disparities in the receipt of preventive care recommended by the American Diabetes Association (ADA) between Appalachian and non-Appalachian counties and within Appalachian counties. RESEARCH DESIGN AND METHODS: Behavioral Risk Factor Surveillance System (BRFSS) data for 2008-2010 were used to identify individuals with diabetes and their preventive care usage. Each Appalachian respondent county of residence was categorised into one of the five economic levels: distressed, at-risk, transitional, competitive and attainment counties...
2016: BMJ Open Diabetes Research & Care
Valentine Y Njike, Rockiy G Ayettey, Hamid Rajebi, Judith A Treu, David L Katz
BACKGROUND: The inclusion of eggs as part of a healthful diet for adults with diabetes is controversial. We examined the effects of including eggs in the diet of adults with type 2 diabetes on cardiometabolic risk factors. METHODS: Randomized, controlled, single-blind, crossover trial of 34 adults (mean age 64.5 years; 14 postmenopausal women, 20 men) with type 2 diabetes assigned to one of two possible sequence permutations of two different 12-week treatments (two eggs/day inclusion or egg exclusion), with 6-week washout periods...
2016: BMJ Open Diabetes Research & Care
James C Barton, J Clayborn Barton, Paul C Adams, Ronald T Acton
OBJECTIVE: To determine prevalences and predictors of undiagnosed diabetes mellitus (UDM) and impaired fasting glucose (IFG) in non-Hispanic whites with HFE p.C282Y homozygosity and controls without common HFE mutations identified in population screening. RESEARCH DESIGN AND METHODS: We analyzed these observations in a postscreening examination: age; sex; body mass index; systolic/diastolic blood pressure; metacarpophalangeal joint hypertrophy; hepatomegaly; blood neutrophils; alanine and aspartate aminotransferase; elevated C reactive protein; transferrin saturation; serum ferritin; and Field Center...
2016: BMJ Open Diabetes Research & Care
Kezia A Præstmark, Morten L Jensen, Nils B Madsen, Jonas Kildegaard, Bente M Stallknecht
OBJECTIVE: Pen needles used for subcutaneous injections have gradually become shorter, thinner and more thin walled, and thereby less robust to patient reuse. Thus, different needle sizes, alternative tip designs and needles resembling reuse were tested to explore how needle design influences ease of insertion, pain and skin trauma. RESEARCH DESIGN AND METHODS: 30 subjects with injection-treated type 2 diabetes and body mass index 25-35 kg/m(2) were included in the single-blinded study...
2016: BMJ Open Diabetes Research & Care
Sergio A Burgos, Vikram Chandurkar, Michael A Tsoukas, Stéphanie Chevalier, José A Morais, Marie Lamarche, Errol B Marliss
OBJECTIVE: To test whether protein anabolic resistance is an early defect in type 2 diabetes (T2D). RESEARCH DESIGN AND METHODS: Seven lean, normoglycemic T2D offspring (T2D-O) and eight matched participants without family history (controls; C) underwent a 3-hour hyperinsulinemic (40 mU/m(2)/min), euglycemic (5.5 mmol/L) and isoaminoacidemic clamp. Whole-body glucose and protein kinetics were measured with d-[3-(3)H]glucose and l-[l-(13)C]leucine, respectively...
2016: BMJ Open Diabetes Research & Care
Kyle S Stumetz, Joyce P Yi-Frazier, Connor Mitrovich, Kathaleen Briggs Early
BACKGROUND: Type 1 diabetes mellitus (T1DM) presents a significant health burden for patients and families. The quality of care (QOC) among those living in rural communities is thought to be subpar compared with those in urban communities; however, little data exist to reflect this, especially in pediatric diabetes. OBJECTIVE: The purpose of this pilot study was to investigate diabetes QOC among families living in rural versus urban areas. 6 QOC markers were used to compare youth with T1DM: appointment adherence, patient-provider communication, diabetes education during clinic visit, congruency with diabetes standards of care, diabetes self-management behaviors, and diabetes-related hospitalizations...
2016: BMJ Open Diabetes Research & Care
Rebecca Paprott, Kristin Mühlenbruch, Gert B M Mensink, Silke Thiele, Matthias B Schulze, Christa Scheidt-Nave, Christin Heidemann
OBJECTIVE: To evaluate the German Diabetes Risk Score (GDRS) among the general adult German population for prediction of incident type 2 diabetes and detection of prevalent undiagnosed diabetes. METHODS: The longitudinal sample for prediction of incident diagnosed type 2 diabetes included 3625 persons who participated both in the examination survey in 1997-1999 and the examination survey in 2008-2011. Incident diagnosed type 2 diabetes was defined as first-time physician diagnosis or antidiabetic medication during 5 years of follow-up excluding potential incident type 1 and gestational diabetes...
2016: BMJ Open Diabetes Research & Care
Stephen P Juraschek, Edgar R Miller, Elizabeth Selvin, Vincent J Carey, Lawrence J Appel, Robert H Christenson, Frank M Sacks
OBJECTIVE: The glycemic index (GI) of dietary carbohydrate is thought to affect glucose homeostasis. Recently, the Effect of Amount and Type of Dietary Carbohydrates on Risk for Cardiovascular Heart Disease and Diabetes Study (OmniCarb) trial reported that a low-GI diet did not improve insulin sensitivity. We conducted this ancillary study of the OmniCarb trial to determine the effects of GI and carbohydrate content on glucose homeostasis and inflammation. RESEARCH DESIGN AND METHODS: OmniCarb was a randomized cross-over feeding study conducted in overweight or obese adults without diabetes (N=163)...
2016: BMJ Open Diabetes Research & Care
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