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BMJ Open Diabetes Research & Care

Aleksandra M Zuk, Carlos R Quiñonez, Olli Saarela, Ryan T Demmer, Laura C Rosella
Objective: Periodontitis is strongly associated with diabetes and is increasingly shown to be associated with other glycemic abnormalities. Vitamin D is postulated to have both anti-inflammatory and antimicrobial activity. Therefore, our aim was to investigate the joint effects of both serum 25-hydroxyvitamin D3 and total 25-hydroxyvitamin D with periodontitis on homeostatic model assessment for insulin resistance (HOMA-IR), pre-diabetes, and type 2 diabetes. Research design and methods: Using data from the 2009-2010 National Health and Nutrition Examination Survey, the sample was restricted to adults over 30 years of age, who were eligible for oral health examination, and had vitamin D, fasting glucose and insulin measures...
2018: BMJ Open Diabetes Research & Care
William E Kraus, Thomas Yates, Jaakko Tuomilehto, Jie-Lena Sun, Laine Thomas, John J V McMurray, M Angelyn Bethel, Rury R Holman
Objective: Physical activity is related to clinical outcomes, even after adjusting for body mass, but is rarely assessed in randomized clinical trials. Research design and methods: We conducted an observational analysis of data from the Nateglinide and Valsartan in Impaired Glucose Tolerance Outcomes Research trial, in which a total of 9306 people from 40 countries with impaired glucose tolerance and either cardiovascular disease or cardiovascular risk factors were randomized to receive nateglinide or placebo, in a 2-by-2 factorial design with valsartan or placebo...
2018: BMJ Open Diabetes Research & Care
Abdulqawi Al Mansari, Youssef Obeid, Najmul Islam, Mohammed Fariduddin, Ahmed Hassoun, Khier Djaballah, Mojtaba Malek, Dror Dicker, Tirthankar Chaudhury
Objective: The American Diabetes Association and the European Association for the Study of Diabetes guidelines recommend to individualize treatment targets/strategies in inadequately controlled patients by lifestyle management and glucose-lowering drugs to decrease the burden of diabetes-related complications. This real-world practice study aimed to assess predictive factors for achieving the glycemic hemoglobin A1c (HbA1c) at 6 months as targeted by the treating physician in adults with type 2 diabetes who required initiation of basal insulin, initiation of bolus insulin, or modification from basal or premixed insulin to new insulin regimen containing insulin glargine and/or insulin glulisine...
2018: BMJ Open Diabetes Research & Care
(no author information available yet)
[This corrects the article DOI: 10.1136/bmjdrc-2018-000531.].
2018: BMJ Open Diabetes Research & Care
Kristin Mühlenbruch, Rebecca Paprott, Hans-Georg Joost, Heiner Boeing, Christin Heidemann, Matthias B Schulze
Objective: The German Diabetes Risk Score (GDRS) is a diabetes prediction model which only includes non-invasively measured risk factors. The aim of this study was to extend the original GDRS by hemoglobin A1c (HbA1c) and validate this clinical GDRS in the nationwide German National Health Interview and Examination Survey 1998 (GNHIES98) cohort. Research design and methods: Extension of the GDRS was based on the European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam study with baseline assessment conducted between 1994 and 1998 (N=27 548, main age range 35-65 years)...
2018: BMJ Open Diabetes Research & Care
Frances Wensley, Christopher Kerry, Gerry Rayman
Aims: Diabetes increases the risk of costly and potentially preventable hospital-acquired pressure ulceration. Given that peripheral arterial disease and neuropathy, important risk factors for foot ulceration, are more common in people with diabetes, their risk of hospital-acquired foot ulceration (HAFU) in particular may be even greater. This study aims to determine this risk. Methods: Using data collected over 2 years from all admissions to the Ipswich Hospital NHS Trust, we conducted a prospective multilevel regression analysis of the risk of HAFU in 5043 admissions of people with diabetes versus 23 599 without diabetes...
2018: BMJ Open Diabetes Research & Care
Mahée Gilbert-Ouimet, Huiting Ma, Rick Glazier, Chantal Brisson, Cameron Mustard, Peter M Smith
Objective: According to the International Diabetes Federation, the most important challenge for prevention is now to identify social and environmental modifiable risk factors of diabetes. In this regard, long work hours have recently been linked with diabetes, but more high-quality prospective studies are needed. We evaluated the relationship between long work hours and the incidence of diabetes among 7065 workers over a 12-year period in Ontario, Canada. Research design and methods: Data from Ontario respondents (35-74 years of age) to the 2003 Canadian Community Health Survey were prospectively linked to the Ontario Health Insurance Plan database for physician services and the Canadian Institute for Health Information Discharge Abstract Database for hospital admissions...
2018: BMJ Open Diabetes Research & Care
Russell Drummond, Ankita Baru, Marcelina Dutkiewicz, Amaury Basse, Bengt-Olov Tengmark
Objective: This study aimed to build on the current clinical findings and investigate physicians' experiences and level of satisfaction in using insulin degludec/liraglutide (IDegLira) to treat patients with type 2 diabetes (T2D). Research design and methods: This multicountry, European online survey included respondents from primary (n=132) and secondary (n=103) care and examined physicians' use, confidence and satisfaction with IDegLira. To standardize responses, 24 of 28 questions pertained to an 'average patient' with T2D who has no major comorbidities, aged 35-70 years, with average cognitive ability/normal mental status and body mass index ≥25 kg/m2 ...
2018: BMJ Open Diabetes Research & Care
Giacomo Zoppini, Corinna Bergamini, Stefano Bonapace, Maddalena Trombetta, Alessandro Mantovani, Anna Toffalini, Laura Lanzoni, Lorenzo Bertolini, Luciano Zenari, Enzo Bonora, Giovanni Targher, Andrea Rossi
Background: Type 2 diabetes may alter cardiac structure and function. Many patients with type 2 diabetes have diastolic dysfunction with preserved ejection fraction (EF). Recently, this latter measure was criticised. Thus, this research looked at the impact of left ventricular end-diastolic volume and E/e' ratio variations in patients with type 2 diabetes and preserved EF with the aim to recognise different clinical phenotypes. Methods: In this cross-sectional study, we evaluated 176 men affected by type 2 diabetes with transthoracic echocardiography...
2018: BMJ Open Diabetes Research & Care
Sridharan Raghavan, Wenhui G Liu, David R Saxon, Gary K Grunwald, Thomas M Maddox, Jane E B Reusch, Seth A Berkowitz, Liron Caplan
Objective: To determine whether sulfonylurea use, compared with non-sulfonylurea oral diabetes medication use, was associated with 2-year mortality in individuals with well-controlled diabetes and coronary artery disease (CAD). Research design and methods: We studied 5352 US veterans with type 2 diabetes, obstructive CAD on coronary angiography, hemoglobin A1c ≤7.5% at the time of catheterization, and taking zero or one oral diabetes medication (categorized as no medications, non-sulfonylurea medication, or sulfonylurea)...
2018: BMJ Open Diabetes Research & Care
Surya Prakash Bhatt, Anoop Misra, Seema Gulati, Naamrata Singh, Ravindra Mohan Pandey
Background: Asian Indian women are predisposed to develop obesity, metabolic syndrome and vitamin D deficiency. Relationship of vitamin D deficiency with blood glucose levels has not been explored in Asian Indian women with pre-diabetes. Objective: We evaluated the associations of serum 25-hydroxy vitamin D (25(OH)D) concentrations among adult women with the pre-diabetes residing in North India (Delhi). Methods: This cross-sectional population-based study involved 797 women with pre-diabetes aged 20-60 years...
2018: BMJ Open Diabetes Research & Care
Faith Agbozo, Abdulai Abubakari, Clement Narh, Albrecht Jahn
Objective: Despite the short-term and long-term health implications of gestational diabetes mellitus (GDM), opinions are divided on selective vis-à-vis universal screening. We validated the accuracy of screening tests for GDM. Research design and methods: Pregnant women (n=491) were recruited to this prospective, blind comparison with a gold standard study. We did selective screening between 13 and 20 weeks using reagent-strip glycosuria, random capillary blood glucose (RBG) and the presence of ≥1 risk factor(s)...
2018: BMJ Open Diabetes Research & Care
Hiroki Yokoyama, Shin-Ichi Araki, Koichi Kawai, Katsuya Yamazaki, Osamu Tomonaga, Shin-Ichiro Shirabe, Hiroshi Maegawa
Objective: We examined changes in prevalence of diabetic microvascular/macrovascular complications and diabetes care indicators for adults in Japan with type 2 and type 1 diabetes over one decade. Research design and methods: Two independent cohorts were recruited with the same inclusion criteria in 2004 (cohort 1: 3319 with type 2 and 286 with type 1 diabetes) and in 2014 (cohort 2: 3932 with type 2 and 308 with type 1 diabetes). Prevalence of complications and care indicators including achieving treatment targets for glycemia, blood pressure, lipid control, body mass index (BMI), and smoking were compared...
2018: BMJ Open Diabetes Research & Care
Nazim Ghouri, Sufyan Hussain, Ruzwan Mohammed, Salem Arifi Beshyah, Tahseen A Chowdhury, Naveed Sattar, Aziz Sheikh
A large proportion of the Muslim population fasts during Ramadan. The risk of hypoglycemia is increased with fasting during Ramadan in people with diabetes who are on insulin and insulin secretagogues. Therefore, the combination of fasting with diabetes and driving presents a challenging situation, with legal implications for such individuals and their healthcare professionals. This novel, narrative, non-systematic review discusses the importance of addressing hypoglycemia in fasting with reference to secular legal guidance on driving with diabetes...
2018: BMJ Open Diabetes Research & Care
John S Leeds, Marios Hadjivassiliou, Solomon Tesfaye, David S Sanders
Objectives: Lower gastrointestinal symptoms are not well characterized in people with type 1 diabetes, and the effects on quality of life and glycemic control are unknown. This study aimed to determine the prevalence of lower gastrointestinal symptoms and the effects on glycemic control and quality of life, and to investigate for underlying causes. Research design and methods: This is a prospective, cohort study in secondary care. Patients with type 1 diabetes completed a gastrointestinal symptom questionnaire and the Short Form 36 V...
2018: BMJ Open Diabetes Research & Care
Ebenezer A Nyenwe, Cherechi C Ogwo, Ibiye Owei, Jim Y Wan, Samuel Dagogo-Jack
Objective: Resting energy expenditure (REE) is linked to obesity, insulin resistance and type 2 diabetes (T2DM). REE and T2DM are inherited traits. Therefore, we investigated the effect of parental T2DM on REE in normoglycemic subjects. Methods: Eighty-seven subjects with parental T2DM and 83 subjects without parental T2DM were matched in age, gender, race, BMI, weight and waist circumference. Subjects underwent a 75 g oral glucose tolerance test; REE was determined by indirect calorimetry and body composition was assessed by dual energy X-ray absorptiometry...
2018: BMJ Open Diabetes Research & Care
William Martinez, Kenneth A Wallston, David G Schlundt, Gerald B Hickson, Kemberlee R Bonnet, Ricardo J Trochez, Tom A Elasy
Objective: Social comparisons (ie, self-evaluation in comparison with others) influence patients' perspectives of their disease and may impact motivation and health behavior; however, little is known about patients' perspectives toward receiving such information in a clinical context (eg, from their doctor's office or health system). This study aims to understand patients' perspectives and anticipated responses to receiving social comparison information regarding measures of their diabetes-related health status (eg, A1C) and how receiving such information would compare with goal-based comparisons (ie, self-evaluation in comparison with goal)...
2018: BMJ Open Diabetes Research & Care
Anne Jølle, Bjørn Olav Åsvold, Jostein Holmen, Sven Magnus Carlsen, Jaakko Tuomilehto, Johan Håkon Bjørngaard, Kristian Midthjell
Objective: Among individuals at high risk for diabetes identified through a population survey, we performed an intervention study with basic lifestyle advice aiming to prevent diabetes. Research design and methods: Among 50 806 participants in the HUNT3 Survey (2006-2008), 5297 individuals with Finnish Diabetes Risc Score (FINDRISC ≥15 were invited to an oral glucose tolerance test (OGTT) and an education session with lifestyle advice, and 2634 (49.7%) attended...
2018: BMJ Open Diabetes Research & Care
Raju P Sapkota, Tirthalal Upadhyaya, Govind Gurung, Mike Parker, Rajiv Raman, Shahina Pardhan
Objective/introduction: It is known that knowledge, awareness, and practice influence diabetic control. We compared factors pertaining to healthy lifestyle (exercising, avoiding smoking), self-help (attending appointments, following treatment regimens), and diabetic awareness in high-risk patients for diabetic complications, specifically, those on insulin versus non-insulin treatment, and also those with a longer diabetic duration (≥5 years) versus a shorter duration. Methods: 200 consecutive patients with type 2 diabetes (52...
2018: BMJ Open Diabetes Research & Care
Jason Gordon, Phil McEwan, Iskandar Idris, Marc Evans, Jorge Puelles
Objective: Using primary care data obtained from the UK Clinical Practice Research Datalink, this retrospective cohort study examined the relationships between medication adherence and clinical outcomes in patients with type 2 diabetes. Research design and methods: Data were extracted for patients treated between 2008 and 2016, and stratified by oral antihyperglycemic agent (OHA) line of therapy (mono, dual or triple therapy). Patients were monitored for up to 365 days; associations between medication possession ratio (MPR) and outcomes at 1 year (glycated hemoglobin A1c (HbA1c), weight and hypoglycemia incidence) were assessed using linear regression modeling and descriptive analyses...
2018: BMJ Open Diabetes Research & Care
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