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BMJ Open Diabetes Research & Care

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https://www.readbyqxmd.com/read/28761664/glucose-lowering-effect-of-whey-protein-depends-upon-clinical-characteristics-of-patients-with-type-2-diabetes
#1
Rogelio U Almario, Wendy M Buchan, David M Rocke, Sidika E Karakas
OBJECTIVE: Whey protein (WP) intake has been shown to reduce postprandial glycemia. Majority of WP research in type 2 diabetes (T2DM) involved acute challenge or weight loss studies. It is not known if WP supplementation can provide sustained glucose lowering. Our goal was to investigate the effects of WP on glycemia comprehensively by using continuous glucose monitoring (CGM) while avoiding the confounding effects of variable food intake through controlled feeding. RESEARCH DESIGN AND METHODS: This double-blinded and placebo (PL)-controlled study included 22 patients with T2DM patients (11 male, 11 female; age 57...
2017: BMJ Open Diabetes Research & Care
https://www.readbyqxmd.com/read/28761663/standardized-screening-for-periodontitis-as-an-integral-part-of-multidisciplinary-management-of-adults-with-type-2-diabetes-an-observational-cross-sectional-study-of-cohorts-in-the-usa-and-uk
#2
Andrew S Pumerantz, Susan M Bissett, Fanglong Dong, Cesar Ochoa, Rebecca R Wassall, Heidi Davila, Melanie Barbee, John Nguyen, Pamela Vila, Philip M Preshaw
OBJECTIVE: To determine prevalence and factors predictive of periodontitis by using a standardized assessment model in adults with type 2 diabetes. RESEARCH DESIGN AND METHODS: We performed an observational cross-sectional study to determine the burden of periodontitis in adults with type 2 diabetes attending urban, ambulatory referral centers in the USA and UK. Full-mouth probing was performed and periodontitis was diagnosed based on either a low (≥5 mm at ≥1 site) or high pocket probing-depth threshold (≥6 mm at ≥1 site)...
2017: BMJ Open Diabetes Research & Care
https://www.readbyqxmd.com/read/28761662/which-foods-are-displaced-in-the-diets-of-adults-with-type-2-diabetes-with-the-inclusion-of-eggs-in-their-diets-a-randomized-controlled-crossover-trial
#3
Valentine Y Njike, Rachel Annam, Victoria Christina Costales, Niloufarsadat Yarandi, David L Katz
BACKGROUND: The inclusion or exclusion of specific foods from the overall diet inevitably affects other food choices, and this matter is routinely neglected in dietary guidance and nutritional epidemiology. We examined how the inclusion of eggs in the diets of type 2 diabetics affected dietary pattern. METHODS: Randomized, controlled, single-blind, crossover trial of 34 adults (mean age 64.5 years; 14 women, 20 men) with type 2 diabetes assigned to one of two possible sequence permutations of two different 12-week treatments (two eggs/day or egg exclusion), with 6-week washout periods...
2017: BMJ Open Diabetes Research & Care
https://www.readbyqxmd.com/read/28761661/association-of-diabetic-retinopathy-with-both-sarcopenia-and-muscle-quality-in-patients-with-type-2-diabetes-a-cross-sectional-study
#4
Tatsuya Fukuda, Ryotaro Bouchi, Takato Takeuchi, Yujiro Nakano, Masanori Murakami, Isao Minami, Hajime Izumiyama, Koshi Hashimoto, Takanobu Yoshimoto, Yoshihiro Ogawa
OBJECTIVE: To examine whether the existence and severity of diabetic retinopathy (DR) could be associated with the prevalent sarcopenia and muscle quality in patients with type 2 diabetes. RESEARCH DESIGN AND METHODS: This is a cross-sectional study of 316 patients with type 2 diabetes (mean age 65±12 years; 38% female). Body compositions were measured by the dual-energy X-ray absorptiometry. Patients were divided into three groups: patients without DR (NDR), with non-proliferative DR (NPDR) and proliferative DR (PDR)...
2017: BMJ Open Diabetes Research & Care
https://www.readbyqxmd.com/read/28761660/association-of-the-dash-dietary-pattern-with-insulin-resistance-and-diabetes-in-us-hispanic-latino-adults-results-from-the-hispanic-community-health-study-study-of-latinos-hchs-sol
#5
Leonor Corsino, Daniela Sotres-Alvarez, Nicole M Butera, Anna María Siega-Riz, Cristina Palacios, Cynthia M Pérez, Sandra S Albrecht, Rebecca A Espinoza Giacinto, Marisa Judith Perera, Linda Van Horn, M Larissa Avilés-Santa
OBJECTIVE: To examine the association between diet quality and both diabetes status and insulin resistance in Hispanic/Latino adults, and the extent to which differences in diet quality contribute to differences in outcomes across Hispanic/Latino heritage. RESEARCH DESIGN AND METHODS: Cross-sectional study. Data are from 15 942 individuals enrolled in the Hispanic Community Health Study/Study of Latinos. Diet was ascertained using two 24-hour dietary recalls, and diet quality was measured using the Dietary Approaches to Stop Hypertension (DASH) score (range: 0-80, lowest to highest)...
2017: BMJ Open Diabetes Research & Care
https://www.readbyqxmd.com/read/28761659/the-effect-of-free-diabetes-care-on-metabolic-control-and-on-health-related-quality-of-life-among-youths-with-type-1-diabetes-in-cameroon
#6
Eric Lontchi-Yimagou, Clarisse Mapa-Tassou, Mesmin Y Dehayem, Marie-José Essi, Jude Saji, Remy Takogue, Eugène Sobngwi, Jean Claude Mbanya
OBJECTIVE: To assess the effect of free diabetes care on metabolic control and on health-related quality of life (HRQoL) of youths living with type 1 diabetes in Cameroon. RESEARCH DESIGN AND METHODS: We conducted a clinical audit of a multicenter prospective cohort, performed in three of the nine clinics of the 'Changing Diabetes in Children' (CDiC) project in Cameroon. We collected data on demography, glycemic control, diabetes acute complications, and patients' HRQoL at baseline and after 1 year of follow-up...
2017: BMJ Open Diabetes Research & Care
https://www.readbyqxmd.com/read/28761658/anagliptin-ameliorates-albuminuria-and-urinary-liver-type-fatty-acid-binding-protein-excretion-in-patients-with-type-2-diabetes-with-nephropathy-in-a-glucose-lowering-independent-manner
#7
Munehiro Kitada, Shin-Ichi Tsuda, Kazunori Konishi, Ai Takeda-Watanabe, Mizue Fujii, Keizo Kanasaki, Makoto Nishizawa, Atsushi Nakagawa, Daisuke Koya
OBJECTIVE: The objective of this study is to elucidate the effect of anagliptin on glucose/lipid metabolism and renoprotection in patients with type 2 diabetic nephropathy. METHODS: Twenty-five patients with type 2 diabetic nephropathy received anagliptin 200 mg/day for 24 weeks, and 20 patients who were switched to anagliptin from other dipeptidyl peptidase-4 (DPP-4) inhibitors were analyzed regarding primary and secondary endpoints. The primary endpoint was change in hemoglobin A1c (HbA1c) during treatment with anagliptin...
2017: BMJ Open Diabetes Research & Care
https://www.readbyqxmd.com/read/28761657/improving-the-transition-from-pediatric-to-adult-diabetes-care-the-pediatric-care-provider-s-perspective-in-quebec-canada
#8
Meranda Nakhla, Lorraine E Bell, Sarah Wafa, Kaberi Dasgupta
OBJECTIVES: The transition from pediatric to adult care is a high-risk period for the emerging adult with diabetes. We aimed to determine adequacy of pediatric transition care structures and explore the pediatric diabetes care provider's perceptions of transition care. RESEARCH DESIGN AND METHODS: In-depth interviews with pediatric diabetes care providers from 12 diabetes centers in Quebec were conducted. We queried alignment with Got Transition's six core elements of healthcare transition, experiences, and barriers to transition care...
2017: BMJ Open Diabetes Research & Care
https://www.readbyqxmd.com/read/28761656/androstenedione-and-testosterone-levels-correlate-with-in-vitro-fertilization-rates-in-insulin-resistant-women
#9
Thozhukat Sathyapalan, Emily H Dickerson, Stephen M Maguiness, John Robinson, Youssra H Z Dakroury, Stephen L Atkin
BACKGROUND: The free androgen index (FAI) calculated using total testosterone measured by immunoassay does not correlate with oocyte fertilization rates; however, there is considerable cross-reactivity for testosterone with other androgens by immunoassay that is not found using isotope dilution liquid chromatography-tandem mass spectrometry (LC/MS/MS). AIMS: This study was done to determine relationship between total testosterone and androstenedione measured by LC/MS/MS and fertilization rates...
2017: BMJ Open Diabetes Research & Care
https://www.readbyqxmd.com/read/28761655/changes-in-risk-factors-and-their-contribution-to-reduction-of-mortality-risk-following-gastric-bypass-surgery-among-obese-individuals-with-type-2-diabetes-a-nationwide-matched-observational-cohort-study
#10
Vasileios Liakopoulos, Stefan Franzén, Ann-Marie Svensson, Björn Zethelius, Johan Ottosson, Ingmar Näslund, Soffia Gudbjörnsdottir, Björn Eliasson
OBJECTIVE: We recently showed that Roux-en-Y gastric bypass (RYGB) reduces risks of mortality, cardiovascular death and myocardial infarction in obese individuals compared with matched patients with diabetes mellitus (DM). We have examined changes in risk factors after RYGB, with the aim of explaining these effects. RESEARCH DESIGN AND METHODS: We matched (1:1) 6132 RYGB patients with DM reported to the Scandinavian Obesity Surgery Register with patients who had not undergone RYGB, based on sex, age, body mass index (BMI) and time, and assessed effects 2007-2014...
2017: BMJ Open Diabetes Research & Care
https://www.readbyqxmd.com/read/28761654/treatment-patterns-and-clinical-characteristics-of-patients-with-type-2-diabetes-mellitus-according-to-body-mass-index-findings-from-an-electronic-medical-records-database
#11
Wayne Weng, Ye Tian, Edward S Kimball, Sheldon X Kong, Jonathan Bouchard, Todd M Hobbs, Brian Sakurada
OBJECTIVE: This study evaluated relationships between glycaemic control, body mass index (BMI), comorbidities and pharmacological treatment in patients with type 2 diabetes mellitus (T2D). RESEARCH DESIGN AND METHODS: This was a retrospective, cross-sectional analysis of Quintiles electronic medical records research data (study period 1 October 2013-30 September 2014). Eligibility included age ≥18 years, T2D diagnosis, and at least one available BMI measurement...
2017: BMJ Open Diabetes Research & Care
https://www.readbyqxmd.com/read/28761653/individuals-with-obesity-and-type-2-diabetes-have-additional-immune-dysfunction-compared-with-obese-individuals-who-are-metabolically-healthy
#12
Caroline Richard, Michael Wadowski, Susan Goruk, Lisa Cameron, Arya M Sharma, Catherine J Field
OBJECTIVE: The objective of the current study was to compare the responses to different ex vivo immunogenic challenges between immune cells derived from metabolically healthy subjects with obesity and subjects with obesity and type 2 diabetes. RESEARCH DESIGN AND METHODS: We recruited 10 metabolically healthy subjects with obesity (Edmonton Obesity Staging System (EOSS) stage 0) and 9 subjects with obesity and type 2 diabetes (EOSS stage 2) aged between 21 years and 70 years and matched for body mass index...
2017: BMJ Open Diabetes Research & Care
https://www.readbyqxmd.com/read/28761652/incidence-of-severe-hypoglycemia-in-children-with-type-1-diabetes-in-the-nordic-countries-in-the-period-2008-2012-association-with-hemoglobin-a-1c-and-treatment-modality
#13
N H Birkebaek, A K Drivvoll, K Aakeson, R Bjarnason, A Johansen, U Samuelsson, T Skrivarhaug, A V Thorsson, J Svensson
OBJECTIVE: Treatment of type 1 diabetes has been intensified aiming at normalizing blood glucose, which may increase the risk of severe hypoglycemia (SH). We aimed to compare the incidence of SH events in the four Nordic countries Denmark, Iceland, Norway and Sweden, and to assess the influence of hemoglobin A1c (HbA1c) and treatment modalities on the frequency of SH; particularly, to explore if a HbA1c target ≤6.7% (50 mmol/mol) is feasible. RESEARCH DESIGN AND METHODS: Data on children below 15 years with a diabetes duration more than 1 year, registered in the national childhood diabetes databases in the four Nordic countries from 2008 to 2012, were compiled...
2017: BMJ Open Diabetes Research & Care
https://www.readbyqxmd.com/read/28761651/type-2-diabetes-patient-s-perspective-on-ramadan-fasting-a-qualitative-study
#14
Jun Yang Lee, Chee Piau Wong, Christina San San Tan, Nazrila Hairizan Nasir, Shaun Wen Huey Lee
OBJECTIVE: We evaluated the beliefs, experience and diabetes management strategies of type 2 diabetes mellitus (T2DM) Muslim patients that chose to fast during Ramadan. RESEARCH DESIGN AND METHODS: A semistructured focus group interview was conducted with 53 participants with T2DM. Participants were purposefully sampled and asked to share their perspective on Ramadan fasting. All interviews were audio recorded, transcribed verbatim and analyzed thematically. RESULTS: Participants reported optimism towards fasting during Ramadan, as they believed that fasting was beneficial to their overall well-being, and a time for family bonding...
2017: BMJ Open Diabetes Research & Care
https://www.readbyqxmd.com/read/28761650/pioglitazone-and-risk-of-mortality-in-patients-with-type-2-diabetes-results-from-a-european-multidatabase-cohort-study
#15
Helen Strongman, Pasi Korhonen, Rachael Williams, Shahram Bahmanyar, Fabian Hoti, Solomon Christopher, Maila Majak, Leanne Kool-Houweling, Marie Linder, Paul Dolin, Edith M Heintjes
OBJECTIVES: Estimate and compare the risk of mortality in patients whose antidiabetic therapy is modified to include pioglitazone compared with an alternative antidiabetic medication at the same stage of disease progression. DESIGN: Retrospective cohort study. SETTING: Pooled analysis of clinical data collected from primary and/or secondary care settings in four European countries: Finland, The Netherlands, Sweden and the UK . PARTICIPANTS: 56 337 patients with type 2 diabetes mellitus first prescribed pioglitazone between 2000 and 2011, and 56 337 patients never prescribed pioglitazone matched by treatment stage, history of diabetes, diabetes complications and cardiovascular disease, and year of cohort entry using exact and propensity score matching...
2017: BMJ Open Diabetes Research & Care
https://www.readbyqxmd.com/read/28761649/discovering-successful-strategies-for-diabetic-self-management-a-qualitative-comparative-study
#16
Susan C Weller, Roberta Baer, Anita Nash, Noe Perez
OBJECTIVE: This project explored lifestyles of patients in good and poor control to identify naturally occurring practices and strategies that result in successful diabetes management. RESEARCH DESIGN AND METHODS: Semistructured interviews with adult patients with type 2 diabetes explored diet, food preparation, physical activity, medication use and glucose monitoring. Patients (n=56) were classified into good (A1C <7.0%), fair (7.0%<A1C<8.0%) or poor (A1C >8...
2017: BMJ Open Diabetes Research & Care
https://www.readbyqxmd.com/read/28761648/education-immigration-and-income-as-risk-factors-for-hemoglobin-a1c-70-mmol-mol-when-diagnosed-with-type-2-diabetes-or-latent-autoimmune-diabetes-in-adult-a-population-based-cohort-study
#17
Mats Martinell, Ronnie Pingel, Johan Hallqvist, Mozhgan Dorkhan, Leif Groop, Anders Rosengren, Petter Storm, Jan Stålhammar
OBJECTIVES: The aim of this research is to study education, income and immigration as risk factors for high hemoglobin A1c (HbA1c >70 mmol/mol (8.6%)) when diagnosed with type 2 diabetes (T2D) or latent autoimmune diabetes in the adult (LADA). RESEARCH DESIGN AND METHODS: Patients were included from the All New Diabetics in Scania study (2008-2013). Level of education, disposable income and immigration year were retrieved from the longitudinal integrated database for labour market research (LISA) register compiled by Statistics Sweden...
2017: BMJ Open Diabetes Research & Care
https://www.readbyqxmd.com/read/28761647/the-association-between-diabetes-mellitus-and-incident-infections-a-systematic-review-and-meta-analysis-of-observational-studies
#18
Waseem Abu-Ashour, Laurie Twells, James Valcour, Amy Randell, Jennifer Donnan, Patricia Howse, John-Michael Gamble
OBJECTIVE: To quantify the association between diabetes and the risk of incident infections by conducting a systematic review and meta-analysis. RESEARCH DESIGN AND METHODS: Two reviewers independently screened articles identified from PubMed, EMBASE, Cochrane Library, IPA, and Web of Science databases. Cohort studies (CS) or case-control studies (CCS) evaluating the incidence of infections in adults with diabetes were included. Infections were classified as: skin and soft tissue, respiratory, blood, genitourinary, head and neck, gastrointestinal, bone, viral, and non-specified infections...
2017: BMJ Open Diabetes Research & Care
https://www.readbyqxmd.com/read/28761646/psychometric-validation-of-the-hypoglycemia-fear-survey-ii-hfs-ii-in-singapore
#19
Amanda Yun Rui Lam, Xiaohui Xin, Wee Boon Tan, Daphne Su-Lyn Gardner, Su-Yen Goh
OBJECTIVE: We conducted a cross-sectional study to adapt and validate the Hypoglycemia Fear Survey-II (HFS-II) for use in Singapore among persons with type 1 and 2 diabetes mellitus. RESEARCH DESIGN AND METHODS: A total of 144 patients with type 1 or 2 diabetes on insulin therapy for at least a year completed the HFS-II between September and December 2013 in the Diabetes Center at Singapore General Hospital. We examined the validity (content, concurrent and discriminant validity, and construct validity) and reliability (internal consistency and test-retest reliability) of the instrument...
2017: BMJ Open Diabetes Research & Care
https://www.readbyqxmd.com/read/28761645/is-glycemia-control-in-canadians-with-diabetes-individualized-a-cross-sectional-observational-study
#20
Michael J Coons, Michelle Greiver, Babak Aliarzadeh, Christopher Meaney, Rahim Moineddin, Tyler Williamson, John Queenan, Catherine H Yu, David G White, Tara Kiran, Jennifer J Kane
OBJECTIVE: Diabetes guidelines recommend individualized glycemic targets: tighter control in younger, healthier patients and consideration of more moderate control in the elderly and those with coexisting illnesses. Our objective was to examine whether glycemic control varied by age and comorbidities in Canadian primary care. RESEARCH DESIGN AND METHODS: Cross-sectional study using data from the electronic medical records of 537 primary care providers across Canada; 30 416 patients with diabetes, aged 40 or above, with at least one encounter and one hemoglobin A1c (HbA1c) measurement between 1 January 2012 and 31 December 2013...
2017: BMJ Open Diabetes Research & Care
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