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BMJ Open Diabetes Research & Care

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https://www.readbyqxmd.com/read/28611921/adherence-of-self-monitoring-of-blood-glucose-in-persons-with-type-1-diabetes-in-sweden
#1
Peter Moström, Elsa Ahlén, Henrik Imberg, Per-Olof Hansson, Marcus Lind
OBJECTIVE: The primary aim was to evaluate the extent to which persons with type 1 diabetes perform self-monitoring of blood glucose (SMBG) according to guidelines. Secondary objectives were to investigate predictors for good SMBG adherence, reasons for non-adherence, and association between SMBG frequency and hemoglobin A1c (HbA1c). METHODS: This was a survey-based cross-sectional study. Questionnaires were sent out to 600 random patients at five sites. Patients were included if they were diagnosed with type 1 diabetes and ≥18 years old and excluded if they were currently using continuous glucose monitoring (CGM)...
2017: BMJ Open Diabetes Research & Care
https://www.readbyqxmd.com/read/28461899/do-influenza-and-pneumococcal-vaccines-prevent-community-acquired-respiratory-infections-among-older-people-with-diabetes-and-does-this-vary-by-chronic-kidney-disease-a-cohort-study-using-electronic-health-records
#2
Helen I McDonald, Sara L Thomas, Elizabeth R C Millett, Jennifer Quint, Dorothea Nitsch
OBJECTIVE: We aimed to estimate the effectiveness of influenza and 23-valent pneumococcal polysaccharide vaccination on reducing the burden of community-acquired lower respiratory tract infection (LRTI) among older people with diabetes, and whether this varied by chronic kidney disease (CKD) status. RESEARCH DESIGN AND METHODS: We used linked UK electronic health records for a retrospective cohort study of 190 492 patients ≥65 years with diabetes mellitus and no history of renal replacement therapy, 1997-2011...
2017: BMJ Open Diabetes Research & Care
https://www.readbyqxmd.com/read/28405346/safety-and-efficacy-of-saxagliptin-for-glycemic-control-in-non-critically-ill-hospitalized-patients
#3
Rajesh Garg, Brooke Schuman, Shelley Hurwitz, Cheyenne Metzger, Shreya Bhandari
OBJECTIVE: To evaluate whether saxagliptin is non-inferior to basal-bolus insulin therapy for glycemic control in patients with controlled type 2 diabetes mellitus (T2DM) admitted to hospital with non-critical illnesses. RESEARCH DESIGN AND METHODS: This was an open-label, randomized controlled clinical trial. Patients received either saxagliptin or basal-bolus insulin, both with correctional insulin doses. The main study outcome was the mean daily blood glucose (BG) after the first day of randomization...
2017: BMJ Open Diabetes Research & Care
https://www.readbyqxmd.com/read/28405345/lower-glycemic-load-meals-reduce-diurnal-glycemic-oscillations-in-women-with-risk-factors-for-gestational-diabetes
#4
Nathalie V Kizirian, Janina Goletzke, Shannon Brodie, Fiona S Atkinson, Tania P Markovic, Glynis P Ross, Anette Buyken, Jennie P Brand-Miller
OBJECTIVE: Maternal glycemia plays a key role in fetal growth. We hypothesized that lower glycemic load (GL) meals (lower glycemic index, modestly lower carbohydrate) would substantially reduce day-long glucose variability in women at risk of gestational diabetes mellitus (GDM). RESEARCH DESIGN AND METHODS: A crossover study of 17 women (mean±SD age 34.8±4 years; gestational weeks 29.3±1.3; body mass index 23.8±4.7 kg/m(2)) who consumed a low GL or a high GL diet in random order, 1-day each, over 2 consecutive days...
2017: BMJ Open Diabetes Research & Care
https://www.readbyqxmd.com/read/28405344/successful-long-term-weight-loss-among-participants-with-diabetes-receiving-an-intervention-promoting-an-adapted-mediterranean-style-dietary-pattern-the-heart-healthy-lenoir-project
#5
Genevieve G R Embree, Carmen D Samuel-Hodge, Larry F Johnston, Beverly A Garcia, Ziya Gizlice, Kelly R Evenson, Darren A DeWalt, Alice S Ammerman, Thomas C Keyserling
OBJECTIVE: To examine weight change by diabetes status among participants receiving a Mediterranean-style diet, physical activity, and weight loss intervention adapted for delivery in the southeastern USA, where rates of cardiovascular disease (CVD) are disproportionately high. RESEARCH DESIGN AND METHODS: The intervention included: Phase I (months 1-6), an individually tailored intervention promoting a Mediterranean-style dietary pattern and increased walking; Phase II (months 7-12), option of a 16-week weight loss intervention for those with BMI≥25 kg/m(2) offered as 16 weekly group sessions or 5 group sessions and 10 phone calls, or a lifestyle maintenance intervention; and Phase III (months 13-24), weight loss maintenance intervention for those losing ≥8 pounds with all others receiving a lifestyle maintenance intervention...
2017: BMJ Open Diabetes Research & Care
https://www.readbyqxmd.com/read/28405343/role-of-depression-in-diabetes-management-in-an-ethnic-minority-population-a-case-of-korean-americans-with-type-2-diabetes
#6
Miyong To Kim, Kim Byeng Kim, Jisook Ko, Yuri Jang, David Levine, Hochang Benjamin Lee
BACKGROUND: Comorbid depression and diabetes mellitus (DM) compound challenges to disease management such as low health literacy, insufficient access to care, and social or linguistic isolation. Korean Americans (KAs), predominantly first-generation immigrants, suffer from a high prevalence of type 2 DM and depression. Limited research on KAs has prevented the development of effective interventions. OBJECTIVES: To compare the prevalence of depression in KAs with DM and all Americans with/without DM, and to explore correlates of comorbid DM and depression and strategies to address KAs' DM and depression...
2017: BMJ Open Diabetes Research & Care
https://www.readbyqxmd.com/read/28405342/association-between-secondhand-smoke-and-obesity-and-glucose-abnormalities-data-from-the-national-health-and-nutrition-examination-survey-nhanes-1999-2010
#7
Dulcie Kermah, Magda Shaheen, Deyu Pan, Theodore C Friedman
OBJECTIVE: The objective of this study is to investigate the relationship between cotinine level-confirmed secondhand smoke (SHS) exposure and glycemic parameters and obesity. RESEARCH DESIGN AND METHODS: We examined a cohort of 6472 adults from the National Health and Nutrition Examination Surveys, 1999-2010. Serum cotinine levels and self-reported data on smoking were used to determine smoking status. The outcome variables were body mass index (BMI) and glycemic status (HbA1c), Homeostasis Model Assessment of Insulin Resistance (HOMA-IR), and fasting plasma glucose (FPG)...
2017: BMJ Open Diabetes Research & Care
https://www.readbyqxmd.com/read/28405341/diabetes-incidence-and-glucose-intolerance-prevalence-increase-with-higher-outdoor-temperature
#8
Lisanne L Blauw, N Ahmad Aziz, Martijn R Tannemaat, C Alexander Blauw, Anton J de Craen, Hanno Pijl, Patrick C N Rensen
OBJECTIVE: Rising global temperatures might contribute to the current worldwide diabetes epidemic, as higher ambient temperature can negatively impact glucose metabolism via a reduction in brown adipose tissue activity. Therefore, we examined the association between outdoor temperature and diabetes incidence in the USA as well as the prevalence of glucose intolerance worldwide. RESEARCH DESIGN AND METHODS: Using meta-regression, we determined the association between mean annual temperature and diabetes incidence during 1996-2009 for each US state separately...
2017: BMJ Open Diabetes Research & Care
https://www.readbyqxmd.com/read/28405340/association-of-physiological-and-psychological-health-outcomes-with-physical-activity-and-sedentary-behavior-in-adults-with-type-2-diabetes
#9
Jeanette M Garcia, Daniel Cox, David J Rice
PURPOSE: To examine the association between change in moderate-to-vigorous physical activity (MVPA) and sedentary behavior (SB) over a 6-month period with physiological and psychological factors in adults with type 2 diabetes (T2D). METHODS: Participants included 26 middle-aged (mean age=56.1±10.8 years; 42% women), overweight/obese (mean body mass index (BMI) =37.22±8.78 kg/m(2)) adults who had been diagnosed with T2D within the past 5 years (mean HbA1c=7...
2017: BMJ Open Diabetes Research & Care
https://www.readbyqxmd.com/read/28321314/obesity-paradox-and-mortality-in-adults-with-and-without-incident-type-2-diabetes-a-matched-population-level-cohort-study
#10
Ellena Badrick, Matthew Sperrin, Iain E Buchan, Andrew G Renehan
OBJECTIVE: Among adults with type 2 diabetes (T2D), several (but not all) studies show that being overweight (body mass index (BMI): 25.0-29.9 kg/m(2)) or obese I (BMI: 30.0-34.9 kg/m(2)) near the time of diagnosis, is unexpectedly associated with reduced all-cause mortality compared with normal weight-the obesity paradox. We addressed whether this observation is causal (eg, a true protective effect); due to confounding (including effect modification); or due to selection ('collider') bias...
2017: BMJ Open Diabetes Research & Care
https://www.readbyqxmd.com/read/28321313/correlation-study-of-adenosine-deaminase-and-its-isoenzymes-in-type-2-diabetes-mellitus
#11
Lokendra Bahadur Sapkota, Sangita Thapa, Nuwadatta Subedi
OBJECTIVE: Adenosine deaminase (ADA) plays an important role in cell-mediated immunity and modulation of insulin activity. Its clinical and diagnostic significance in Nepalese type 2 diabetes is not yet characterized. So, this study's objective was to determine the isoenzymatic activities of ADA (ADA1, ADA2, and total ADA) and show its correlation with demographic, anthropometric, and biochemical characteristics of type 2 Nepalese subjects with diabetes. RESEARCH DESIGN AND METHODS: This is a hospital-based cross-sectional study including 80 type 2 diabetes mellitus (DM) patients and same number of age-matched and sex-matched healthy controls...
2017: BMJ Open Diabetes Research & Care
https://www.readbyqxmd.com/read/28321312/preserved-glucagon-like-peptide-1-responses-to-oral-glucose-but-reduced-incretin-effect-insulin-secretion-and-sensitivity-in-young-asians-with-type-2-diabetes-mellitus
#12
Toh Peng Yeow, Giovanni Pacini, Andrea Tura, Chee Peng Hor, Shueh Lin Lim, Florence Hui Sieng Tan, Chin Voon Tong, Janet Yeow Hua Hong, Fuziah Md Zain, Jens Juul Holst, Wan Nazaimoon Wan Mohamud
OBJECTIVE: Youth onset type 2 diabetes mellitus (YT2DM) is a globally rising phenomenon with substantial Asians representation. The understanding of its pathophysiology is derived largely from studies in the obese African-American and Caucasian populations, while studies on incretin effect are scarce. We examined the insulin resistance, β-cell function (BC), glucagon-like peptide (GLP)-1 hormone and incretin effect in Asian YT2DM. RESEARCH DESIGN AND METHODS: This case-control study recruited 25 Asian YT2DM and 15 healthy controls, matched for gender, ethnicity and body mass index...
2017: BMJ Open Diabetes Research & Care
https://www.readbyqxmd.com/read/28316796/systematic-review-and-meta-analysis-of-dietary-carbohydrate-restriction-in-patients-with-type-2-diabetes
#13
Ole Snorgaard, Grith M Poulsen, Henning K Andersen, Arne Astrup
OBJECTIVE: Nutrition therapy is an integral part of self-management education in patients with type 2 diabetes. Carbohydrates with a low glycemic index are recommended, but the ideal amount of carbohydrate in the diet is unclear. We performed a meta-analysis comparing diets containing low to moderate amounts of carbohydrate (LCD) (energy percentage below 45%) to diets containing high amounts of carbohydrate (HCD) in subjects with type 2 diabetes. RESEARCH DESIGN AND METHODS: We systematically reviewed Cochrane library databases, EMBASE, and MEDLINE in the period 2004-2014 for guidelines, meta-analyses, and randomized trials assessing the outcomes HbA1c, BMI, weight, LDL cholesterol, quality of life (QoL), and attrition...
2017: BMJ Open Diabetes Research & Care
https://www.readbyqxmd.com/read/28316795/impact-of-weight-loss-on-waist-circumference-and-the-components-of-the-metabolic-syndrome
#14
Amy E Rothberg, Laura N McEwen, Andrew T Kraftson, Nevin Ajluni, Christine E Fowler, Catherine K Nay, Nicole M Miller, Charles F Burant, William H Herman
OBJECTIVE: Central adiposity is a component of the metabolic syndrome (MetS). Little is known about the impact of medical weight loss and decreased waist circumference (WC) on the MetS. Our objective was to assess the impact of changes in WC on blood pressure, lipids and glycemia. RESEARCH DESIGN AND METHODS: We studied 430 obese patients enrolled in a 2-year, intensive, behavioral, weight management program. We report results for participants who completed 6-month and 2-year follow-up...
2017: BMJ Open Diabetes Research & Care
https://www.readbyqxmd.com/read/28316794/periodontitis-as-a-possible-early-sign-of-diabetes-mellitus
#15
Wijnand J Teeuw, Madeline X F Kosho, Dennis C W Poland, Victor E A Gerdes, Bruno G Loos
OBJECTIVE: The early diagnosis of (pre)diabetes mellitus is essential for the prevention of diabetes complications. It has been suggested that gum disease (periodontitis) might be an early complication of diabetes and may be a useful risk indicator for diabetes screening. Therefore, a dental office could be a good location for screening for (pre)diabetes in patients with periodontitis using a validated glycated hemoglobin (HbA1c) dry spot analysis. RESEARCH DESIGN AND METHODS: A total of 313 individuals from a university dental clinic participated...
2017: BMJ Open Diabetes Research & Care
https://www.readbyqxmd.com/read/28316793/development-and-validation-of-an-instrument-to-measure-collaborative-goal-setting-in-the-care-of-patients-with-diabetes
#16
Heather L Morris, Levent Dumenci, Jennifer E Lafata
OBJECTIVE: Despite known benefits of patient-perceived collaborative goal setting, we have a limited ability to monitor this process in practice. We developed the Patient Measure of Collaborative Goal Setting (PM-CGS) to evaluate the use of collaborative goal setting from the patient's perspective. RESEARCH DESIGN AND METHODS: A random sample of 400 patients aged 40 years or older, receiving diabetes care from the Virginia Commonwealth University Health System between 8/2012 and 8/2013, were mailed a survey containing potential PM-CGS items (n=44) as well as measures of patient demographics, perceived self-management competence, trust in their physician, and self-management behaviors...
2017: BMJ Open Diabetes Research & Care
https://www.readbyqxmd.com/read/28243450/willingness-of-patients-with-diabetes-to-use-an-ict-based-self-management-tool-a-cross-sectional-study
#17
Tomomi Shibuta, Kayo Waki, Nobuko Tomizawa, Ayumi Igarashi, Noriko Yamamoto-Mitani, Satoko Yamaguchi, Hideo Fujita, Shigeko Kimura, Katsuhito Fujiu, Hironori Waki, Yoshihiko Izumida, Takayoshi Sasako, Masatoshi Kobayashi, Ryo Suzuki, Toshimasa Yamauchi, Takashi Kadowaki, Kazuhiko Ohe
OBJECTIVES: To examine the prevalence of the willingness of patients with diabetes to use a self-management tool based on information and communication technology (ICT) such as personal computers, smartphones, and mobile phones; and to examine the patient characteristics associated with that willingness. RESEARCH DESIGN AND METHODS: We conducted a cross-sectional interview survey of 312 adults with diabetes at a university hospital in an urban area in Japan. Participants were classified into 2 groups: those who were willing to use an ICT-based self-management tool and those who were unwilling...
2017: BMJ Open Diabetes Research & Care
https://www.readbyqxmd.com/read/28243449/performance-of-the-freestyle-libre-flash-glucose-monitoring-system-in-patients-with-type-1-and-2-diabetes-mellitus
#18
M J Fokkert, P R van Dijk, M A Edens, S Abbes, D de Jong, R J Slingerland, H J G Bilo
OBJECTIVE: To evaluate the performance of the FreeStyle Libre Flash continuous glucose monitoring (FSL-CGM) system against established central laboratory methods. RESEARCH DESIGN AND METHODS: 20 subjects (8 type 1 diabetes mellitus, 12 type 2 diabetes mellitus) were analyzed. FSL-CGM sensor measurements (inserted in arm and abdomen) were compared with capillary blood glucose results analyzed with StatStrip as semigold standard. The glucose response after a standardized oral glucose load was measured by FSL-CGM and capillary samples analyzed by perchloric acid hexokinase (PCA-HK) method, StatStrip and FSL test strip (FSLC), and a commonly used CGM system (iPro2)...
2017: BMJ Open Diabetes Research & Care
https://www.readbyqxmd.com/read/28243448/problem-solving-therapy-for-adults-with-diabetic-retinopathy-and-diabetes-specific-distress-a-pilot-randomized-controlled-trial
#19
Gwyneth Rees, Fleur O'Hare, Marian Saeed, Bronwyn Sudholz, Bonnie A Sturrock, Jing Xie, Jane Speight, Ecosse L Lamoureux
OBJECTIVE: To provide preliminary evidence for the impact of problem-solving therapy for diabetes (PST-D) in adults with diabetic retinopathy (DR) and diabetes distress. RESEARCH DESIGN AND METHODS: In a pilot randomized controlled trial, 40 participants with DR and diabetes distress were allocated to the PST-D or control groups. Diabetes distress (DDS), depressive symptoms (PHQ-9), self-care activities (SDSCA), and HbA1c were assessed at baseline, and 3 and 6-month follow-ups...
2017: BMJ Open Diabetes Research & Care
https://www.readbyqxmd.com/read/28243447/using-in-vivo-corneal-confocal-microscopy-to-identify-diabetic-sensorimotor-polyneuropathy-risk-profiles-in-patients-with-type-1-diabetes
#20
Evan J H Lewis, Bruce A Perkins, Lief E Lovblom, Richard P Bazinet, Thomas M S Wolever, Vera Bril
OBJECTIVE: Diabetic sensorimotor peripheral neuropathy (DSP) is the most prevalent complication in diabetes mellitus. Identifying DSP risk is essential for intervening early in the natural history of the disease. Small nerve fibers are affected earliest in the disease progression and evidence of this damage can be identified using in vivo corneal confocal microscopy (IVCCM). RESEARCH DESIGN AND METHODS: We applied IVCCM to a cohort of 40 patients with type 1 diabetes to identify their DSP risk profile...
2017: BMJ Open Diabetes Research & Care
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