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BMJ Open Diabetes Research & Care

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https://www.readbyqxmd.com/read/29892340/declining-trends-of-diabetic-nephropathy-retinopathy-and-neuropathy-with-improving-diabetes-care-indicators-in-japanese-patients-with-type-2-and-type-1-diabetes-jddm-46
#1
Hiroki Yokoyama, Shin-Ichi Araki, Koichi Kawai, Katsuya Yamazaki, Osamu Tomonaga, Shin-Ichiro Shirabe, Hiroshi Maegawa
Objective: We examined changes in prevalence of diabetic microvascular/macrovascular complications and diabetes care indicators for adults in Japan with type 2 and type 1 diabetes over one decade. Research design and methods: Two independent cohorts were recruited with the same inclusion criteria in 2004 (cohort 1: 3319 with type 2 and 286 with type 1 diabetes) and in 2014 (cohort 2: 3932 with type 2 and 308 with type 1 diabetes). Prevalence of complications and care indicators including achieving treatment targets for glycemia, blood pressure, lipid control, body mass index (BMI), and smoking were compared...
2018: BMJ Open Diabetes Research & Care
https://www.readbyqxmd.com/read/29892339/diabetes-driving-and-fasting-during-ramadan-the-interplay-between-secular-and-religious-law
#2
REVIEW
Nazim Ghouri, Sufyan Hussain, Ruzwan Mohammed, Salem Arifi Beshyah, Tahseen A Chowdhury, Naveed Sattar, Aziz Sheikh
A large proportion of the Muslim population fasts during Ramadan. The risk of hypoglycemia is increased with fasting during Ramadan in people with diabetes who are on insulin and insulin secretagogues. Therefore, the combination of fasting with diabetes and driving presents a challenging situation, with legal implications for such individuals and their healthcare professionals. This novel, narrative, non-systematic review discusses the importance of addressing hypoglycemia in fasting with reference to secular legal guidance on driving with diabetes...
2018: BMJ Open Diabetes Research & Care
https://www.readbyqxmd.com/read/29892338/lower-gastrointestinal-symptoms-are-associated-with-worse-glycemic-control-and-quality-of-life-in-type-1-diabetes-mellitus
#3
John S Leeds, Marios Hadjivassiliou, Solomon Tesfaye, David S Sanders
Objectives: Lower gastrointestinal symptoms are not well characterized in people with type 1 diabetes, and the effects on quality of life and glycemic control are unknown. This study aimed to determine the prevalence of lower gastrointestinal symptoms and the effects on glycemic control and quality of life, and to investigate for underlying causes. Research design and methods: This is a prospective, cohort study in secondary care. Patients with type 1 diabetes completed a gastrointestinal symptom questionnaire and the Short Form 36 V...
2018: BMJ Open Diabetes Research & Care
https://www.readbyqxmd.com/read/29892337/parental-history-of-type-2-diabetes-is-associated-with-lower-resting-energy-expenditure-in-normoglycemic-subjects
#4
Ebenezer A Nyenwe, Cherechi C Ogwo, Ibiye Owei, Jim Y Wan, Samuel Dagogo-Jack
Objective: Resting energy expenditure (REE) is linked to obesity, insulin resistance and type 2 diabetes (T2DM). REE and T2DM are inherited traits. Therefore, we investigated the effect of parental T2DM on REE in normoglycemic subjects. Methods: Eighty-seven subjects with parental T2DM and 83 subjects without parental T2DM were matched in age, gender, race, BMI, weight and waist circumference. Subjects underwent a 75 g oral glucose tolerance test; REE was determined by indirect calorimetry and body composition was assessed by dual energy X-ray absorptiometry...
2018: BMJ Open Diabetes Research & Care
https://www.readbyqxmd.com/read/29862032/patients-perspectives-on-social-and-goal-based-comparisons-regarding-their-diabetes-health-status
#5
William Martinez, Kenneth A Wallston, David G Schlundt, Gerald B Hickson, Kemberlee R Bonnet, Ricardo J Trochez, Tom A Elasy
Objective: Social comparisons (ie, self-evaluation in comparison with others) influence patients' perspectives of their disease and may impact motivation and health behavior; however, little is known about patients' perspectives toward receiving such information in a clinical context (eg, from their doctor's office or health system). This study aims to understand patients' perspectives and anticipated responses to receiving social comparison information regarding measures of their diabetes-related health status (eg, A1C) and how receiving such information would compare with goal-based comparisons (ie, self-evaluation in comparison with goal)...
2018: BMJ Open Diabetes Research & Care
https://www.readbyqxmd.com/read/29765613/basic-lifestyle-advice-to-individuals-at-high-risk-of-type-2-diabetes-a-2-year-population-based-diabetes-prevention-study-the-de-plan-intervention-in-the-hunt-study-norway
#6
Anne Jølle, Bjørn Olav Åsvold, Jostein Holmen, Sven Magnus Carlsen, Jaakko Tuomilehto, Johan Håkon Bjørngaard, Kristian Midthjell
Objective: Among individuals at high risk for diabetes identified through a population survey, we performed an intervention study with basic lifestyle advice aiming to prevent diabetes. Research design and methods: Among 50 806 participants in the HUNT3 Survey (2006-2008), 5297 individuals with Finnish Diabetes Risc Score (FINDRISC ≥15 were invited to an oral glucose tolerance test (OGTT) and an education session with lifestyle advice, and 2634 (49.7%) attended...
2018: BMJ Open Diabetes Research & Care
https://www.readbyqxmd.com/read/29755757/need-to-improve-awareness-and-treatment-compliance-in-high-risk-patients-for-diabetic-complications-in-nepal
#7
Raju P Sapkota, Tirthalal Upadhyaya, Govind Gurung, Mike Parker, Rajiv Raman, Shahina Pardhan
Objective/introduction: It is known that knowledge, awareness, and practice influence diabetic control. We compared factors pertaining to healthy lifestyle (exercising, avoiding smoking), self-help (attending appointments, following treatment regimens), and diabetic awareness in high-risk patients for diabetic complications, specifically, those on insulin versus non-insulin treatment, and also those with a longer diabetic duration (≥5 years) versus a shorter duration. Methods: 200 consecutive patients with type 2 diabetes (52...
2018: BMJ Open Diabetes Research & Care
https://www.readbyqxmd.com/read/29755756/treatment-choice-medication-adherence-and-glycemic-efficacy-in-people-with-type-2-diabetes-a-uk-clinical-practice-database-study
#8
Jason Gordon, Phil McEwan, Iskandar Idris, Marc Evans, Jorge Puelles
Objective: Using primary care data obtained from the UK Clinical Practice Research Datalink, this retrospective cohort study examined the relationships between medication adherence and clinical outcomes in patients with type 2 diabetes. Research design and methods: Data were extracted for patients treated between 2008 and 2016, and stratified by oral antihyperglycemic agent (OHA) line of therapy (mono, dual or triple therapy). Patients were monitored for up to 365 days; associations between medication possession ratio (MPR) and outcomes at 1 year (glycated hemoglobin A1c (HbA1c), weight and hypoglycemia incidence) were assessed using linear regression modeling and descriptive analyses...
2018: BMJ Open Diabetes Research & Care
https://www.readbyqxmd.com/read/29732164/association-of-serum-orosomucoid-with-30-min-plasma-glucose-and-glucose-excursion-during-oral-glucose-tolerance-tests-in-non-obese-young-japanese-women
#9
Ayaka Tsuboi, Satomi Minato, Megumu Yano, Mika Takeuchi, Kaori Kitaoka, Miki Kurata, Gen Yoshino, Bin Wu, Tsutomu Kazumi, Keisuke Fukuo
Objective: Inflammatory markers are elevated in insulin resistance (IR) and diabetes. We tested whether serum orosomucoid (ORM) is associated with postload glucose, β-cell dysfunction and IR inferred from plasma insulin kinetics during a 75 g oral glucose tolerance test (OGTT). Research design and methods: 75 g OGTTs were performed with multiple postload glucose and insulin measurements over a 30-120 min period in 168 non-obese Japanese women (aged 18-24 years)...
2018: BMJ Open Diabetes Research & Care
https://www.readbyqxmd.com/read/29713481/intent-to-treat-analysis-of-a-simultaneous-multisite-telehealth-diabetes-prevention-program
#10
Elizabeth L Ciemins, Patricia J Coon, Nicholas C Coombs, Barbara L Holloway, Elizabeth J Mullette, William N Dudley
Objective: Determine the effectiveness of a 16-week modified diabetes prevention program (DPP) administered simultaneously to multiple rural communities from a single urban site, as compared with a similar face-to-face intervention. A 12-week intervention was evaluated to consider minimization of staff costs in communities where resources are limited. Research design and methods: A prospective cohort study compared DPP interventions implemented in rural (via telehealth technology) and urban (face-to-face) communities using an intent-to-treat analysis...
2018: BMJ Open Diabetes Research & Care
https://www.readbyqxmd.com/read/29713480/real-world-crude-incidence-of-hypoglycemia-in-adults-with-diabetes-results-of-the-inhypo-dm-study-canada
#11
Alexandria Ratzki-Leewing, Stewart B Harris, Selam Mequanint, Sonja M Reichert, Judith Belle Brown, Jason Edward Black, Bridget L Ryan
Objective: Very few real-world studies have been conducted to assess the incidence of diabetes-related hypoglycemia. Moreover, there is a paucity of studies that have investigated hypoglycemia among people taking secretagogues as a monotherapy or in combination with insulin. Accordingly, our research team developed and validated the InHypo-DM Person with Diabetes Mellitus Questionnaire (InHypo-DMPQ) with the aim of capturing the real-world incidence of self-reported, symptomatic hypoglycemia...
2018: BMJ Open Diabetes Research & Care
https://www.readbyqxmd.com/read/29682291/metformin-in-gestational-diabetes-the-offspring-follow-up-mig-tofu-body-composition-and-metabolic-outcomes-at-7-9-years-of-age
#12
Janet A Rowan, Elaine C Rush, Lindsay D Plank, Jun Lu, Victor Obolonkin, Suzette Coat, William M Hague
Objective: To compare body composition and metabolic outcomes at 7-9 years in offspring of women with gestational diabetes (GDM) randomized to metformin (±insulin) or insulin treatment during pregnancy. Research design and methods: Children were assessed at 7 years in Adelaide (n=109/181) and 9 years in Auckland (n=99/396) by anthropometry, bioimpedance analysis (BIA), dual-energy X-ray absorptiometry (DXA), magnetic resonance imaging (MRI) (n=92/99) and fasting bloods (n=82/99)...
2018: BMJ Open Diabetes Research & Care
https://www.readbyqxmd.com/read/29657719/inpatient-diabetes-management-by-specialized-diabetes-team-versus-primary-service-team-in-non-critical-care-units-impact-on-30-day-readmission-rate-and-hospital-cost
#13
Vivek Bansal, Adham Mottalib, Taranveer K Pawar, Noormuhammad Abbasakoor, Eunice Chuang, Abrar Chaudhry, Mahmoud Sakr, Robert A Gabbay, Osama Hamdy
Objective: We compared the cost-effectiveness of two inpatient diabetes care models: one offered by a specialized diabetes team (SDT) versus a primary service team (PST). Research design and methods: We retrospectively evaluated 756 hospital admissions of patients with diabetes to non-critical care units over 6 months. Out of 392 patients who met the eligibility criteria, 262 were matched 1:1 based on the mean of the initial four blood glucose (BG) values after admission...
2018: BMJ Open Diabetes Research & Care
https://www.readbyqxmd.com/read/29629178/diabetes-risk-score-in-the-united-arab-emirates-a-screening-tool-for-the-early-detection-of-type-2-diabetes-mellitus
#14
Nabil Sulaiman, Ibrahim Mahmoud, Amal Hussein, Salah Elbadawi, Salah Abusnana, Paul Zimmet, Jonathan Shaw
Objective: The objective of this study was to develop a simple non-invasive risk score, specific to the United Arab Emirates (UAE) citizens, to identify individuals at increased risk of having undiagnosed type 2 diabetes mellitus. Research design and methods: A retrospective analysis of the UAE National Diabetes and Lifestyle data was conducted. The data included demographic and anthropometric measurements, and fasting blood glucose. Univariate analyses were used to identify the risk factors for diabetes...
2018: BMJ Open Diabetes Research & Care
https://www.readbyqxmd.com/read/29607050/ursodeoxycholic-acid-potentiates-dipeptidyl-peptidase-4-inhibitor-sitagliptin-by-enhancing-glucagon-like-peptide-1-secretion-in-patients-with-type-2-diabetes-and-chronic-liver-disease-a-pilot-randomized-controlled-and-add-on-study
#15
Kosuke Robert Shima, Tsuguhito Ota, Ken-Ichiro Kato, Yumie Takeshita, Hirofumi Misu, Shuichi Kaneko, Toshinari Takamura
Objective: We evaluated the effects of ursodeoxycholic acid (UDCA) on glucagon-like peptide-1 (GLP-1) secretion and glucose tolerance in patients with type 2 diabetes with chronic liver disease. Research design and methods: Japanese patients with type 2 diabetes (glycated hemoglobin (HbA1c) levels ≥7.0%) and chronic liver disease were included in this study. Sixteen patients (HbA1c level, 7.2%±0.6%(55.2 mmol/mol)) were randomized to receive 900 mg UDCA for 12 weeks followed by 50 mg sitagliptin add-on therapy for 12 weeks (UDCA-first group; n=8) or 50 mg sitagliptin for 12 weeks followed by 900 mg UDCA add-on therapy for 12 weeks (sitagliptin-first group; n=8)...
2018: BMJ Open Diabetes Research & Care
https://www.readbyqxmd.com/read/29607049/periodontitis-edentulism-and-glycemic-control-in-patients-with-type-2-diabetes-a-cross-sectional-study
#16
Zuila Albuquerque Taboza, Katia Linhares Costa, Virginia Régia Silveira, Flavia Aparecida Furlaneto, Renan Montenegro, Stefanie Russell, Ananda Dasanayake, Rodrigo O Rego
Objectives: To compare the glycemic control in non-smoking patients with type 2 diabetes according to their periodontal and dental status. Research design and methods: This cross-sectional study investigated patients previously diagnosed with type 2 diabetes and under antidiabetic medication. Clinical data and fasting blood glucose (FBG) levels were collected from medical and dental records. Patients were divided into three groups according to dental and periodontal diagnosis: no or mild periodontitis (NO/MILD, n=96), moderate or severe periodontitis (MOD/SEV, n=74) and edentulous (n=141)...
2018: BMJ Open Diabetes Research & Care
https://www.readbyqxmd.com/read/29607048/mexican-american-and-south-asian-population-based-cohorts-reveal-high-prevalence-of-type-2-diabetes-and-crucial-differences-in-metabolic-phenotypes
#17
Gordon P Watt, Susan P Fisher-Hoch, Mohammad H Rahbar, Joseph B McCormick, Miryoung Lee, Audrey C Choh, Sadagopan Thanikachalam, Mohan Thanikachalam
Objective: Prevalence of type 2 diabetes varies by region and ancestry. However, most guidelines for the prevention of diabetes mellitus (DM) are based on European or non-Hispanic white populations. Two ethnic minority populations-Mexican Americans (MAs) in Texas, USA, and South Indians (SIs) in Tamil Nadu, India-have an increasing prevalence of DM. We aimed to understand the metabolic correlates of DM in these populations to improve risk stratification and DM prevention. Research design and methods: The Cameron County Hispanic Cohort (CCHC; n=3023) served as the MA sample, and the Population Study of Urban, Rural, and Semi-Urban Regions for the Detection of Endovascular Disease (PURSE; n=8080) served as the SI sample...
2018: BMJ Open Diabetes Research & Care
https://www.readbyqxmd.com/read/29527311/development-and-validation-of-a-prediction-model-for-insulin-associated-hypoglycemia-in-non-critically-ill-hospitalized-adults
#18
Nestoras Nicolas Mathioudakis, Estelle Everett, Shuvodra Routh, Peter J Pronovost, Hsin-Chieh Yeh, Sherita Hill Golden, Suchi Saria
Objective: To develop and validate a multivariable prediction model for insulin-associated hypoglycemia in non-critically ill hospitalized adults. Research design and methods: We collected pharmacologic, demographic, laboratory, and diagnostic data from 128 657 inpatient days in which at least 1 unit of subcutaneous insulin was administered in the absence of intravenous insulin, total parenteral nutrition, or insulin pump use (index days). These data were used to develop multivariable prediction models for biochemical and clinically significant hypoglycemia (blood glucose (BG) of ≤70 mg/dL and <54 mg/dL, respectively) occurring within 24 hours of the index day...
2018: BMJ Open Diabetes Research & Care
https://www.readbyqxmd.com/read/29527310/appendicular-muscle-mass-and-fasting-triglycerides-predict-serum-liver-aminotransferases-in-young-female-collegiate-athletes
#19
Satomi Minato, Kaori Kitaoka, Mika Takeuchi, Ayaka Tsuboi, Miki Kurata, Shigehiro Tanaka, Tsutomu Kazumi, Keisuke Fukuo
Objective: We test the hypothesis that aspartate aminotransferase (AST) may be associated inversely with serum triglycerides (TG) and positively with high density lipoprotein (HDL) cholesterol in young athletes because athletes have larger amounts of muscle mass. Research design and methods: Pearson's correlation coefficients were calculated between serum AST and alanine aminotransferase (ALT) and body composition identified by dual-energy X-ray absorptiometry, markers of insulin resistance, serum lipids, lipoproteins, apolipoproteins, adiponectin and leptin in 174 female collegiate athletes (18-22 years)...
2018: BMJ Open Diabetes Research & Care
https://www.readbyqxmd.com/read/29527309/association-of-type-1-diabetes-and-concentrations-of-drinking-water-components-in-newfoundland-and-labrador-canada
#20
Roger Chafe, Rana Aslanov, Atanu Sarkar, Peter Gregory, Alex Comeau, Leigh Anne Newhook
Objective: To determine the association between drinking water quality and rates of type 1 diabetes in the Newfoundland and Labrador (NL) population, which has one of the highest incidences of type 1 diabetes reported globally. Research design and methods: The study used a community-based, case-control design. We first calculated incidence rates of type 1 diabetes at the provincial, regional and community levels. The connection between incidence rates and components in public water supplies were then analyzed in three ways: to evaluate differences in water quality between communities with and without incident cases of type 1 diabetes, and to analyze the relationship between water quality and incidence rates of type 1 diabetes at both the community and regional levels...
2018: BMJ Open Diabetes Research & Care
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