Read by QxMD icon Read

Scientific Data

Dominika A Rudzka, William Clark, Ann Hedley, Gabriela Kalna, Michael F Olson
The metastatic spread of cancer cells is a step-wise process that starts with dissociation from primary tumours and local invasion of adjacent tissues. The ability to invade local tissues is the product of several processes, including degradation of extracellular matrices (ECM) and movement of tumour cells through physically-restricting gaps. To identify properties contributing to tumour cells squeezing through narrow gaps, invasive MDA-MB-231 human breast cancer and MDA-MB-435 human melanoma cells were subjected to three successive rounds of selection using cell culture inserts with highly constraining 3 μm pores...
November 14, 2017: Scientific Data
Fernando Domínguez-Castro, José Manuel Vaquero, María Cruz Gallego, Ana María Marín Farrona, Juan Carlos Antuña-Marrero, Erika Elizabeth Cevallos, Ricardo García Herrera, Cristina de la Guía, Raúl David Mejía, José Manuel Naranjo, María Del Rosario Prieto, Luis Enrique Ramos Guadalupe, Lizardo Seiner, Ricardo Machado Trigo, Marcos Villacís
This paper provides early instrumental data recovered for 20 countries of Latin-America and the Caribbean (Argentina, Bahamas, Belize, Brazil, British Guiana, Chile, Colombia, Costa Rica, Cuba, Ecuador, France (Martinique and Guadalupe), Guatemala, Jamaica, Mexico, Nicaragua, Panama, Peru, Puerto Rico, El Salvador and Suriname) during the 18th and 19th centuries. The main meteorological variables retrieved were air temperature, atmospheric pressure, and precipitation, but other variables, such as humidity, wind direction, and state of the sky were retrieved when possible...
November 14, 2017: Scientific Data
José López-Cedrún, Urbano Santana-Mora, María Pombo, Amaya Pérez Del Palomar, Víctor Alonso De la Peña, María Jesús Mora, Urbano Santana
This study assessed 24 adult patients, suffering from severe chronic unilateral pain diagnosed as temporomandibular joint (TMJ) disorder (TMD). The full dentate patients had normal occlusion and had never received an occlusal therapy, i.e., were with natural dental evolution/maturation. The following functional and dynamic factors were assessed: (1) chewing function; (2) TMJ remodeling or the condylar path (CP); and (3) lateral jaw motion or lateral guidance (LG). CPs were assessed using conventional axiography, and LG was assessed by K7 jaw tracking...
November 7, 2017: Scientific Data
Marc Hafner, Laura M Heiser, Elizabeth H Williams, Mario Niepel, Nicholas J Wang, James E Korkola, Joe W Gray, Peter K Sorger
Traditional means for scoring the effects of anti-cancer drugs on the growth and survival of cell lines is based on relative cell number in drug-treated and control samples and is seriously confounded by unequal division rates arising from natural biological variation and differences in culture conditions. This problem can be overcome by computing drug sensitivity on a per-division basis. The normalized growth rate inhibition (GR) approach yields per-division metrics for drug potency (GR50) and efficacy (GRmax) that are analogous to the more familiar IC50 and Emax values...
November 7, 2017: Scientific Data
Anna Ehrlund, Juan R Acosta, Christel Björk, Per Hedén, Iyadh Douagi, Peter Arner, Jurga Laurencikiene
Obesity affects gene expression and metabolism of white adipose tissue (WAT), which results in insulin resistance (IR) and type 2 diabetes. However, WAT is a heterogeneous organ containing many cell types that might respond differently to obesity-induced changes. We performed flow cytometry sorting and RNA expression profiling by microarray of major WAT cell types (adipocytes, CD45-/CD31-/CD34+ progenitors, CD45+/CD14+ monocytes/ macrophages, CD45+/CD14- leukocytes), which allowed us to identify genes enriched in specific cell fractions...
October 31, 2017: Scientific Data
Margherita Francescatto, Marina Lizio, Ingrid Philippens, Ronald Bontrop, Mizuho Sakai, Shoko Watanabe, Masayoshi Itoh, Akira Hasegawa, Timo Lassmann, Jessica Severin, Jayson Harshbarger, Imad Abugessaisa, Takeya Kasukawa, Piero Carninci, Yoshihide Hayashizaki, Alistair R R Forrest, Hideya Kawaji, Patrizia Rizzu, Peter Heutink
Rhesus macaque was the second non-human primate whose genome has been fully sequenced and is one of the most used model organisms to study human biology and disease, thanks to the close evolutionary relationship between the two species. But compared to human, where several previously unknown RNAs have been uncovered, the macaque transcriptome is less studied. Publicly available RNA expression resources for macaque are limited, even for brain, which is highly relevant to study human cognitive abilities. In an effort to complement those resources, FANTOM5 profiled 15 distinct anatomical regions of the aged macaque central nervous system using Cap Analysis of Gene Expression, a high-resolution, annotation-independent technology that allows monitoring of transcription initiation events with high accuracy...
October 31, 2017: Scientific Data
Mónica Torres-Beltrán, Alyse K Hawley, David Capelle, Elena Zaikova, David A Walsh, Andreas Mueller, Melanie Scofield, Chris Payne, Larysa Pakhomova, Sam Kheirandish, Jan Finke, Maya Bhatia, Olena Shevchuk, Esther A Gies, Diane Fairley, Céline Michiels, Curtis A Suttle, Frank Whitney, Sean A Crowe, Philippe D Tortell, Steven J Hallam
Extensive and expanding oxygen minimum zones (OMZs) exist at variable depths in coastal and open ocean waters. As oxygen levels decline, nutrients and energy are increasingly diverted away from higher trophic levels into microbial community metabolism, resulting in fixed nitrogen loss and production of climate active trace gases including nitrous oxide and methane. While ocean deoxygenation has been reported on a global scale, our understanding of OMZ biology and geochemistry is limited by a lack of time-resolved data sets...
October 31, 2017: Scientific Data
Steven J Hallam, Mónica Torres-Beltrán, Alyse K Hawley
Today in Scientific Data, two compendia of geochemical and multi-omic sequence information (DNA, RNA, protein) generated over almost a decade of time series monitoring in a seasonally anoxic coastal marine setting are presented to the scientific community. These data descriptors introduce a model ecosystem for the study of microbial responses to ocean deoxygenation, a phenotype that is currently expanding due to climate change. Public access to this time series information is intended to promote scientific collaborations and the generation of new hypotheses relevant to microbial ecology, biogeochemistry and global change issues...
October 31, 2017: Scientific Data
Katie J Quinn, Nigam H Shah
Polypharmacy is increasingly common in the United States, and contributes to the substantial burden of drug-related morbidity. Yet real-world polypharmacy patterns remain poorly characterized. We have counted the incidence of multi-drug combinations observed in four billion patient-months of outpatient prescription drug claims from 2007-2014 in the Truven Health MarketScan® Databases. Prescriptions are grouped into discrete windows of concomitant drug exposure, which are used to count exposure incidences for combinations of up to five drug ingredients or ATC drug classes...
October 31, 2017: Scientific Data
Alyse K Hawley, Mónica Torres-Beltrán, Elena Zaikova, David A Walsh, Andreas Mueller, Melanie Scofield, Sam Kheirandish, Chris Payne, Larysa Pakhomova, Maya Bhatia, Olena Shevchuk, Esther A Gies, Diane Fairley, Stephanie A Malfatti, Angela D Norbeck, Heather M Brewer, Ljiljana Pasa-Tolic, Tijana Glavina Del Rio, Curtis A Suttle, Susannah Tringe, Steven J Hallam
Marine oxygen minimum zones (OMZs) are widespread regions of the ocean that are currently expanding due to global warming. While inhospitable to most metazoans, OMZs are hotspots for microbial mediated biogeochemical cycling of carbon, nitrogen and sulphur, contributing disproportionately to marine nitrogen loss and climate active trace gas production. Our current understanding of microbial community responses to OMZ expansion is limited by a lack of time-resolved data sets linking multi-omic sequence information (DNA, RNA, protein) to geochemical parameters and process rates...
October 31, 2017: Scientific Data
Xuanxuan Li, Chun-Ya Chiu, Hsiang-Ju Wang, Stephan Kassemeyer, Sabine Botha, Robert L Shoeman, Robert M Lawrence, Christopher Kupitz, Richard Kirian, Daniel James, Dingjie Wang, Garrett Nelson, Marc Messerschmidt, Sébastien Boutet, Garth J Williams, Elisabeth Hartmann, Aliakbar Jafarpour, Lutz M Foucar, Anton Barty, Henry Chapman, Mengning Liang, Andreas Menzel, Fenglin Wang, Shibom Basu, Raimund Fromme, R Bruce Doak, Petra Fromme, Uwe Weierstall, Michael H Huang, John C H Spence, Ilme Schlichting, Brenda G Hogue, Haiguang Liu
This corrects the article DOI: 10.1038/sdata.2017.48.
October 24, 2017: Scientific Data
Kate V Atkinson, Lisa A Bishop, Glenn Rhodes, Nicolas Salez, Neil R McEwan, Matthew J Hegarty, Julie Robey, Nicola Harding, Simon Wetherell, Robert M Lauder, Roger W Pickup, Mark Wilkinson, Derek Gatherer
Nasopharyngeal swabs were taken from volunteers attending a general medical practice and a general hospital in Lancaster, UK, and at Lancaster University, in the winter of 2014-2015. 51 swabs were selected based on high RNA yield and allocated to deep sequencing pools as follows: patients with chronic obstructive pulmonary disease; asthmatics; adults with no respiratory symptoms; adults with feverish respiratory symptoms; adults with respiratory symptoms and presence of antibodies against influenza C; paediatric patients with respiratory symptoms (2 pools); adults with influenza C infection (2 pools), giving a total of 9 pools...
October 24, 2017: Scientific Data
George Kim, S V Meschel, Philip Nash, Wei Chen
The standard enthalpy of formation of a compound is the energy associated with the reaction to form the compound from its component elements. The standard enthalpy of formation is a fundamental thermodynamic property that determines its phase stability, which can be coupled with other thermodynamic data to calculate phase diagrams. Calorimetry provides the only direct method by which the standard enthalpy of formation is experimentally measured. However, the measurement is often a time and energy intensive process...
October 24, 2017: Scientific Data
Erin A Marshall, Adam P Sage, Kevin W Ng, Victor D Martinez, Natalie S Firmino, Kevin L Bennewith, Wan L Lam
Only 3% of the transcribed human genome is translated into protein, and small non-coding RNAs from these untranslated regions have demonstrated critical roles in transcriptional and translational regulation of proteins. Here, we provide a resource that will facilitate cell line selection for gene expression studies involving sncRNAs in cancer research. As the most accessible and tractable models of tumours, cancer cell lines are widely used to study cancer development and progression. The NCI-60 panel of 59 cancer cell lines was curated to provide common models for drug screening in 9 tissue types; however, its prominence has extended to use in gene regulation, xenograft models, and beyond...
October 24, 2017: Scientific Data
Yao Zhang, Xiangming Xiao, Xiaocui Wu, Sha Zhou, Geli Zhang, Yuanwei Qin, Jinwei Dong
Accurate estimation of the gross primary production (GPP) of terrestrial vegetation is vital for understanding the global carbon cycle and predicting future climate change. Multiple GPP products are currently available based on different methods, but their performances vary substantially when validated against GPP estimates from eddy covariance data. This paper provides a new GPP dataset at moderate spatial (500 m) and temporal (8-day) resolutions over the entire globe for 2000-2016. This GPP dataset is based on an improved light use efficiency theory and is driven by satellite data from MODIS and climate data from NCEP Reanalysis II...
October 24, 2017: Scientific Data
Alexander Weiss, Michael L Wilson, D Anthony Collins, Deus Mjungu, Shadrack Kamenya, Steffen Foerster, Anne E Pusey
Researchers increasingly view animal personality traits as products of natural selection. We present data that describe the personalities of 128 eastern chimpanzees (Pan troglodytes schweinfurthii) currently living in or who lived their lives in the Kasekela and Mitumba communities of Gombe National Park, Tanzania. We obtained ratings on 24 items from an established, reliable, well-validated questionnaire used to study personality in captive chimpanzee populations. Ratings were made by former and present Tanzanian field assistants who followed individual chimpanzees for years and collected detailed behavioral observations...
October 24, 2017: Scientific Data
Yee Lian Chew, Denise S Walker, Emma K Towlson, Petra E Vértes, Gang Yan, Albert-László Barabási, William R Schafer
Lesioning studies have provided important insight into the functions of brain regions in humans and other animals. In the nematode Caenorhabditis elegans, with a small nervous system of 302 identified neurons, it is possible to generate lesions with single cell resolution and infer the roles of individual neurons in behaviour. Here we present a dataset of ~300 video recordings representing the locomotor behaviour of animals carrying single-cell ablations of 5 different motorneurons. Each file includes a raw video of approximately 27,000 frames; each frame has also been segmented to yield the position, contour, and body curvature of the tracked animal...
October 19, 2017: Scientific Data
Lisa St John-Williams, Colette Blach, Jon B Toledo, Daniel M Rotroff, Sungeun Kim, Kristaps Klavins, Rebecca Baillie, Xianlin Han, Siamak Mahmoudiandehkordi, John Jack, Tyler J Massaro, Joseph E Lucas, Gregory Louie, Alison A Motsinger-Reif, Shannon L Risacher, Andrew J Saykin, Gabi Kastenmüller, Matthias Arnold, Therese Koal, M Arthur Moseley, Lara M Mangravite, Mette A Peters, Jessica D Tenenbaum, J Will Thompson, Rima Kaddurah-Daouk
Alzheimer's disease (AD) is the most common neurodegenerative disease presenting major health and economic challenges that continue to grow. Mechanisms of disease are poorly understood but significant data point to metabolic defects that might contribute to disease pathogenesis. The Alzheimer Disease Metabolomics Consortium (ADMC) in partnership with Alzheimer Disease Neuroimaging Initiative (ADNI) is creating a comprehensive biochemical database for AD. Using targeted and non- targeted metabolomics and lipidomics platforms we are mapping metabolic pathway and network failures across the trajectory of disease...
October 17, 2017: Scientific Data
Antoine A Emery, Chris Wolverton
ABO3 perovskites are oxide materials that are used for a variety of applications such as solid oxide fuel cells, piezo-, ferro-electricity and water splitting. Due to their remarkable stability with respect to cation substitution, new compounds for such applications potentially await discovery. In this work, we present an exhaustive dataset of formation energies of 5,329 cubic and distorted perovskites that were calculated using first-principles density functional theory. In addition to formation energies, several additional properties such as oxidation states, band gap, oxygen vacancy formation energy, and thermodynamic stability with respect to all phases in the Open Quantum Materials Database are also made publicly available...
October 17, 2017: Scientific Data
(no author information available yet)
No abstract text is available yet for this article.
October 17, 2017: Scientific Data
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"