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Translational Perioperative and Pain Medicine

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https://www.readbyqxmd.com/read/27536706/il-33-signaling-in-lung-injury
#1
Jing Chang, Yue-Feng Xia, Ma-Zhong Zhang, Li-Ming Zhang
Interleukin (IL)-33, a member of the IL-1 cytokine super-family, acts as both a traditional cytokine and an intracellular nuclear factor. It is generally released from damaged immune cells and signals through its receptor ST2 in an autocrine and paracrine fashion, plays important roles in type-2 innate immunity, and functions as an "alarmin" or a danger signal for cellular damage or cellular stress. Here, we review recent advances of the role of IL-33 in lung injury and explore its potential significance as an attractive therapeutic target...
2016: Translational Perioperative and Pain Medicine
https://www.readbyqxmd.com/read/27500183/the-crispr-cas9-system-for-gene-editing-and-its-potential-application-in-pain-research
#2
Linlin Sun, Brianna Marie Lutz, Yuan-Xiang Tao
The CRISPR/Cas9 system is a research hotspot in genome editing and regulation. Currently, it is used in genomic silencing and knock-in experiments as well as transcriptional activation and repression. This versatile system consists of two components: a guide RNA (gRNA) and a Cas9 nuclease. Recognition of a genomic DNA target is mediated through base pairing with a 20-base gRNA. The latter further recruits the Cas9 endonuclease protein to the target site and creates double-stranded breaks in the target DNA. Compared with traditional genome editing directed by DNA-binding protein domains, this short RNA-directed Cas9 endonuclease system is simple and easily programmable...
2016: Translational Perioperative and Pain Medicine
https://www.readbyqxmd.com/read/27500182/altered-t-ucrs-expression-profile-in-the-spinal-cord-of-mice-with-neuropathic-pain
#3
Bao-Chun Jiang, Tian Yang, Li-Na He, Yuan-Xiang Tao, Yong-Jing Gao
Spinal cord plays an important role in the transmission and modulation of nociceptive information. Global changes in gene expression in the spinal cord contribute to the induction and maintenance of neuropathic pain. Transcribed Ultraconserved Regions (T-UCRs), a novel class of long noncoding RNAs, can regulate gene expression at both transcriptional and post-transcriptional levels and are related to many human diseases such as cancer, Alzheimer's disease, and heart diseases. In this study, we screened abnormal T-UCRs expression in the spinal cord under spinal nerve ligation (SNL)-induced neuropathic pain condition...
2016: Translational Perioperative and Pain Medicine
https://www.readbyqxmd.com/read/27213169/major-depressive-disorder-and-kappa-opioid-receptor-antagonists
#4
Wei Li, Huijiao Sun, Hao Chen, Xicheng Yang, Li Xiao, Renyu Liu, Liming Shao, Zhuibai Qiu
Major depressive disorder (MDD) is a common psychiatric disease worldwide. The clinical use of tricyclic antidepressants (TCAs), monoamine oxidase inhibitors (MAOIs) and selective serotonin reuptake inhibitors (SSRIs)/serotonin-norepinephrine reuptake inhibitor (SNRIs) for this condition have been widely accepted, but they were challenged by unacceptable side-effects, potential drug-drug interactions (DDIs) or slow onset/lack of efficacy. The endogenous opioid system is involved in stress and emotion regulatory processes and its role in MDD has been implicated...
2016: Translational Perioperative and Pain Medicine
https://www.readbyqxmd.com/read/27182533/a-translational-consideration-of-intercellular-adhesion-molecule-1-biology-in-the-perioperative-setting
#5
Emily Greenwald, Koichi Yuki
Intercellular adhesion molecule-1 (ICAM-1) is a critical adhesion molecule involved in leukocyte recruitment. Since its discovery in 1986, a large number of studies have been performed to elucidate its role in vitro and in vivo. Here, we review its role in leukocyte recruitment and consider future steps to take that will enhance our understanding of ICAM-1 biology and its translational application in the perioperative setting.
2016: Translational Perioperative and Pain Medicine
https://www.readbyqxmd.com/read/26985446/opioid-system-modulates-the-immune-function-a-review
#6
Xuan Liang, Renyu Liu, Chunhua Chen, Fang Ji, Tianzuo Li
Opioid receptors and their ligands produce powerful analgesia that is effective in perioperative period and chronic pain managements accompanied with various side effects including respiratory depression, constipation and addiction etc. Opioids can also interfere with the immune system, not only participating in the function of the immune cells, but also modulating innate and acquired immune responses. The traditional notion of opioids is immunosuppressive. Recent studies indicate that the role of opioid receptors on immune function is complicated, working through various different mechanisms...
2016: Translational Perioperative and Pain Medicine
https://www.readbyqxmd.com/read/26301256/updated-mechanisms-of-sickle-cell-disease-associated-chronic-pain
#7
Brianna Lutz, Steffen E Meiler, Alex Bekker, Yuan-Xiang Tao
Sickle cell disease (SCD), a hemoglobinopathy, causes sickling of red blood cells, resulting in vessel blockage, stroke, anemia, inflammation, and extreme pain. A vast majority of SCD patients experience pain on a chronic basis, and many turn to opioids to provide limited relief. The side effects that come with chronic opioid use push for research into understanding the specific mechanisms of SCD-associated chronic pain. Current advances in SCD-associated pain have focused on alterations in the pain pathway including nociceptor sensitization and endogenous pain inducers...
July 26, 2015: Translational Perioperative and Pain Medicine
https://www.readbyqxmd.com/read/27135043/translational-medicine-a-multidisciplinary-collaborative-and-global-effort
#8
Wei Lu, Wuwei Feng
No abstract text is available yet for this article.
2015: Translational Perioperative and Pain Medicine
https://www.readbyqxmd.com/read/26413558/breastfeeding-after-anesthesia-a-review-for-anesthesia-providers-regarding-the-transfer-of-medications-into-breast-milk
#9
Benjamin Cobb, Renyu Liu, Elizabeth Valentine, Onyi Onuoha
Doctors, nurses, and midwives often inform mothers to "pump and dump" their breast milk for 24 hours after receiving anesthesia to avoid passing medications to the infant. This advice, though cautious, is probably outdated. This review highlights the more recent literature regarding common anesthesia medications, their passage into breast milk, and medication effects observed in breastfed infants. We suggest continuing breastfeeding after anesthesia when the mother is awake, alert, and able to hold her infant...
2015: Translational Perioperative and Pain Medicine
https://www.readbyqxmd.com/read/26366428/ketamine-a-multifaceted-drug
#10
Lingzhong Meng, Jian Li, Yi Lu, Dajin Sun, Yuan-Xiang Tao, Renyu Liu, Jin Jun Luo
There is a petition for tight control of ketamine from the Chinese government to classify ketamine as a Schedule I drug, which is defined as a drug with no currently accepted medical use but a high potential for abuse. However, ketamine has unique properties that can benefit different patient populations. Scholars from the Translational Perioperative and Pain Medicine and the International Chinese Academy of Anesthesiology WeChat groups had an interactive discussion on ketamine, including its current medical applications, future research priorities, and benefits versus risks...
2015: Translational Perioperative and Pain Medicine
https://www.readbyqxmd.com/read/26339682/intrathecal-rapamycin-attenuates-morphine-induced-analgesic-tolerance-and-hyperalgesia-in-rats-with-neuropathic-pain
#11
Ji-Tian Xu, Linlin Sun, Brianna Marie Lutz, Alex Bekker, Yuan-Xiang Tao
Repeated and long-term administration of opioids is often accompanied by the initiation of opioid-induced analgesic tolerance and hyperalgesia in chronic pain patients. Our previous studies showed that repeated intrathecal morphine injection activated the mammalian target of rapamycin complex 1 (mTORC1) in spinal dorsal horn neurons and that blocking this activation prevented the initiation of morphine-induced tolerance and hyperalgesia in healthy rats. However, whether spinal mTORC1 is required for morphine-induced tolerance and hyperalgesia under neuropathic pain conditions remains elusive...
2015: Translational Perioperative and Pain Medicine
https://www.readbyqxmd.com/read/26082931/perspectives-of-translational-medicine
#12
Lingqun Hu, John Zhang, Weifeng Tu, Renyu Liu, Li-Ming Zhang
No abstract text is available yet for this article.
2015: Translational Perioperative and Pain Medicine
https://www.readbyqxmd.com/read/26065012/cerebral-circulation-and-ischemia-how-to-monitor-it-during-surgery
#13
Kun Liu, Hong Liu, Wei Dong Gao, Lingzhong Meng
No abstract text is available yet for this article.
2015: Translational Perioperative and Pain Medicine
https://www.readbyqxmd.com/read/25429367/postoperative-amnesia-in-a-patient-undergoing-general-anesthesia-for-electro-physiologic-ep-catheter-ablation-of-an-irritable-atrial-focus
#14
Aris Sophocles, Linda Chen, David Lin, Renyu Liu
This case report describes the anesthetic management of a 67-year-old who underwent a catheter based pulmonary vein isolation (PVI) of long-standing, persistent atrial fibrillation. When the patient awoke from the 6.5 hour procedure, he was found to have a transient retrograde and anterograde amnesia that persisted for 18-24 hours postoperatively. This is a unique instance of global amnesia following a cardiac ablation procedure under prolonged general anesthesia. This case study highlights important topics in postoperative cognitive deficits including the differential diagnosis, risk factors, and strategies for optimizing patient outcomes in high risk procedures...
October 31, 2014: Translational Perioperative and Pain Medicine
https://www.readbyqxmd.com/read/25505792/the-launch-of-the-translational-perioperative-and-pain-medicine
#15
Renyu Liu
No abstract text is available yet for this article.
July 6, 2014: Translational Perioperative and Pain Medicine
https://www.readbyqxmd.com/read/26023678/outcome-of-carotid-endarterectomy-after-regional-anesthesia-versus-general-anesthesia-a-retrospective-study-using-two-independent-databases
#16
Jiabin Liu, Hecter Martinez-Wilson, Mark D Neuman, Nabil Elkassabany, Edward Andrew Ochroch
BACKGROUND: Carotid endarterectomy (CEA) is effective in reducing stroke risk in selected patient groups. The ideal anesthetic technique remains controversial in light of literature between general anesthesia (GA) and regional anesthesia (RA) for CEA. METHODS: We studied the NSQIP data from 2005 to 2012. There were 32,718 patients receiving general anesthesia (GA) and 5,384 patients receiving regional anesthesia, local anesthesia, or monitored anesthesia care (RA)...
2014: Translational Perioperative and Pain Medicine
https://www.readbyqxmd.com/read/25574482/kappa-opioid-receptor-agonist-and-brain-ischemia
#17
Chen Chunhua, Xi Chunhua, Sugita Megumi, Liu Renyu
Opioid receptors, especially Kappa opioid receptor (KOR) play an important role in the pathophysiological process of cerebral ischemia reperfusion injury. Previously accepted KOR agonists activity has included anti-nociception, cardiovascular, anti-pruritic, diuretic, and antitussive effects, while compelling evidence from various ischemic animal models indicate that KOR agonist have neuroprotective effects through various mechanisms. In this review, we aimed to demonstrate the property of KOR agonist and its role in global and focal cerebral ischemia...
2014: Translational Perioperative and Pain Medicine
https://www.readbyqxmd.com/read/25568887/salvinorin-a-decreases-mortality-and-improves-neurological-outcome-in-a-neonatal-mouse-hypoxia-model
#18
Chunhua Chen, Xu Cui, Felipe Matsunaga, Jingyuan Ma, Nan Ma, Ted Abel, Renyu Liu
No abstract text is available yet for this article.
2014: Translational Perioperative and Pain Medicine
https://www.readbyqxmd.com/read/25568886/anesthesia-providers-are-obligated-to-give-patients-the-alternatives-to-general-anesthesia-when-obtaining-informed-consent
#19
Michael R Pascarella, Jason D Walls, Renyu Liu, Linda Chen
No abstract text is available yet for this article.
2014: Translational Perioperative and Pain Medicine
https://www.readbyqxmd.com/read/25356434/the-anti-nociception-effect-of-dezocine-in-a-rat-neuropathic-pain-model
#20
Fei-Xiang Wu, Rui-Rui Pan, Wei-Feng Yu, Renyu Liu
The treatment of neuropathic pain (NP) currently remains clinically challenging. In an attempt to identify novel targets of known opioids, we found that dezocine, a non-addictive opioid, inhibits norepinephrine and serotonin reuptake through their transporter proteins which open the potential for dezocine to manage NP. In the present study, the effect of dezocine on NP was observed in a rat model of chronic constriction injury (CCI). The paw withdrawal latency (PWL) and paw withdrawal threshold (PWT) were used to evaluate thermal hyperalgesia and mechanic allodynia for nociceptive response...
2014: Translational Perioperative and Pain Medicine
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