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Translational Perioperative and Pain Medicine

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https://www.readbyqxmd.com/read/28435847/stroke-1-2-0-the-strategy-and-video-release
#1
Jing Zhao, Renyu Liu
No abstract text is available yet for this article.
2017: Translational Perioperative and Pain Medicine
https://www.readbyqxmd.com/read/28217719/effects-of-epinephrine-on-inflammation-related-gene-expressions-in-cultured-rat-cardiomyocytes
#2
Stacey Chen, Geoffrey L Liu, Marilyn M Li, Renyu Liu, Henry Liu
Epinephrine, a non-specific adrenergic agonist, is one of the most commonly used inotropes perioperatively. Recent studies have shown that inflammatory response in cardiac surgery could result in hypoperfusion, dysrhythmias, myocardial ischemia, and other pathophysiological alterations in the postoperative period. These alterations might be contributing to the adverse clinical outcome. Although epinephrine has been shown to have effects on the immune system, how epinephrine affects inflammatory response is unclear...
2017: Translational Perioperative and Pain Medicine
https://www.readbyqxmd.com/read/28217718/pediatric-perioperative-stress-responses-and-anesthesia
#3
Koichi Yuki, Erika Matsunami, Kazumasa Tazawa, Wei Wang, James A DiNardo, Sophia Koutsogiannaki
Surgical stress responses cause an array of endocrinological, metabolic and immunological changes in patients. The landmark studies in the 1980s showed that adequate anesthesia dramatically improved the outcomes of pediatric surgical patients by attenuating stress hormonal responses, pointing out the harm of 'inadequate' anesthesia. Subsequent studies questioned the role of administering very high-dose anesthetics to further attenuate stress responses. Here we review the feature of surgical stress responses in pediatric patients including their difference from those in adult patients...
2017: Translational Perioperative and Pain Medicine
https://www.readbyqxmd.com/read/28480314/biomarkers-for-chronic-neuropathic-pain-and-their-potential-application-in-spinal-cord-stimulation-a-review
#4
Chibueze D Nwagwu, Christina Sarris, Yuan-Xiang Tao, Antonios Mammis
This review was focused on understanding which substances inside the human body increase and decrease with increasing neuropathic pain. We reviewed various studies, and saw correlations between neuropathic pain and components of the immune system (this system defends the body against diseases and infections). Our findings will especially be useful for understanding ways to reduce or eliminate the discomfort, chronic neuropathic pain brings with it. Spinal cord stimulation (SCS) procedure is one of the few fairly efficient remedial treatments for pain...
2016: Translational Perioperative and Pain Medicine
https://www.readbyqxmd.com/read/28409174/neurokinin-1-and-opioid-receptors-relationships-and-interactions-in-nervous-system
#5
Jie Xiao, Si Zeng, Xiangrui Wang, Hasan Babazada, Zhanchun Li, Renyu Liu, Weifeng Yu
Opioid receptors and neurokinin 1 receptor (NK1R) are found highly expressed in the central nervous system. The co-localization of these two kinds of receptors suggests that they might interact with each other in both the transmission and modulation of the pain signal. In this review, we explore the relationships between opioid receptors and NK1R. Substance P (SP) plays a modulatory role in the pain transmission by activating the NK1R. Opioid receptor activation can inhibit SP release. NK1R is found participating in the mechanisms of the side effects of the opioids, including opioid analgesic tolerance, hyperalgesia, anxiety behaviors of morphine reward and opioids related respiratory depression...
2016: Translational Perioperative and Pain Medicine
https://www.readbyqxmd.com/read/28217717/dexmedetomidine-induced-neuroprotection-is-it-translational
#6
Yunzhen Wang, Ruquan Han, Zhiyi Zuo
Dexmedetomidine is often used in anesthesia and critical care medicine practice to sedate patients. Its neuroprotective effects have been shown in various ischemic and hemorrhagic brain injury models of animals. Randomized clinical trials have indicated that dexmedetomidine can improve outcome of patients under intensive care. Clinical trials are needed to determine whether dexmedetomidine can provide neuroprotection against ischemic and hemorrhagic stroke.
2016: Translational Perioperative and Pain Medicine
https://www.readbyqxmd.com/read/28191485/the-development-and-application-of-airway-devices-in-china
#7
Xiangdong Chen, Wuhua Ma, Renyu Liu, Shanglong Yao
Airway management is one of the most important tasks for anesthesiologists. Anesthesiologists are experts in airway management and have made tremendous contribution to the development of the airway devices. Chinese anesthesiologists have made significant contribution in introducing advanced airway management and developing innovative techniques and devices for airway management in China. This article overviews the development and application of airway devices in China as well as the dedication and contribution of Chinese experts in the development of novel airway devices...
2016: Translational Perioperative and Pain Medicine
https://www.readbyqxmd.com/read/28105445/calling-for-a-rapid-recognition-and-response-program-for-stroke-in-china
#8
Jing Zhao, Renyu Liu
In this article, we provide evidences indicating that a a rapid recognition and response program based on FAST (face, Arm, Speech, Time) for stroke suitable for China is desperately needed.
2016: Translational Perioperative and Pain Medicine
https://www.readbyqxmd.com/read/28090548/managerial-decision-making-for-daily-case-allocation-scheduling-and-the-impact-on-perioperative-quality-assurance
#9
Minmin Zhu, Zhengli Yang, Xiao Liang, Xiaojie Lu, Gurmukh Sahota, Renyu Liu, Lihua Yi
Allocation scheduling for daily surgical cases is a decision-making process tasked to anesthesiologists and nurse managers in the operating room (OR). This manuscript focuses on three major areas: the classification and principles of allocation scheduling on workdays in China, flexible strategies of operational decision-making given differences in planned versus actual OR allocations, and perioperative quality implications of anesthesia scheduling. Improved quality and optimal decision-making in daily surgical case scheduling is seen with shift supervisor-based scheduling of staff and cases when compared with staff and case scheduling managed by the departmental director or chief resident...
2016: Translational Perioperative and Pain Medicine
https://www.readbyqxmd.com/read/27536706/il-33-signaling-in-lung-injury
#10
Jing Chang, Yue-Feng Xia, Ma-Zhong Zhang, Li-Ming Zhang
Interleukin (IL)-33, a member of the IL-1 cytokine super-family, acts as both a traditional cytokine and an intracellular nuclear factor. It is generally released from damaged immune cells and signals through its receptor ST2 in an autocrine and paracrine fashion, plays important roles in type-2 innate immunity, and functions as an "alarmin" or a danger signal for cellular damage or cellular stress. Here, we review recent advances of the role of IL-33 in lung injury and explore its potential significance as an attractive therapeutic target...
2016: Translational Perioperative and Pain Medicine
https://www.readbyqxmd.com/read/27500183/the-crispr-cas9-system-for-gene-editing-and-its-potential-application-in-pain-research
#11
Linlin Sun, Brianna Marie Lutz, Yuan-Xiang Tao
The CRISPR/Cas9 system is a research hotspot in genome editing and regulation. Currently, it is used in genomic silencing and knock-in experiments as well as transcriptional activation and repression. This versatile system consists of two components: a guide RNA (gRNA) and a Cas9 nuclease. Recognition of a genomic DNA target is mediated through base pairing with a 20-base gRNA. The latter further recruits the Cas9 endonuclease protein to the target site and creates double-stranded breaks in the target DNA. Compared with traditional genome editing directed by DNA-binding protein domains, this short RNA-directed Cas9 endonuclease system is simple and easily programmable...
2016: Translational Perioperative and Pain Medicine
https://www.readbyqxmd.com/read/27500182/altered-t-ucrs-expression-profile-in-the-spinal-cord-of-mice-with-neuropathic-pain
#12
Bao-Chun Jiang, Tian Yang, Li-Na He, Yuan-Xiang Tao, Yong-Jing Gao
Spinal cord plays an important role in the transmission and modulation of nociceptive information. Global changes in gene expression in the spinal cord contribute to the induction and maintenance of neuropathic pain. Transcribed Ultraconserved Regions (T-UCRs), a novel class of long noncoding RNAs, can regulate gene expression at both transcriptional and post-transcriptional levels and are related to many human diseases such as cancer, Alzheimer's disease, and heart diseases. In this study, we screened abnormal T-UCRs expression in the spinal cord under spinal nerve ligation (SNL)-induced neuropathic pain condition...
2016: Translational Perioperative and Pain Medicine
https://www.readbyqxmd.com/read/27213169/major-depressive-disorder-and-kappa-opioid-receptor-antagonists
#13
Wei Li, Huijiao Sun, Hao Chen, Xicheng Yang, Li Xiao, Renyu Liu, Liming Shao, Zhuibai Qiu
Major depressive disorder (MDD) is a common psychiatric disease worldwide. The clinical use of tricyclic antidepressants (TCAs), monoamine oxidase inhibitors (MAOIs) and selective serotonin reuptake inhibitors (SSRIs)/serotonin-norepinephrine reuptake inhibitor (SNRIs) for this condition have been widely accepted, but they were challenged by unacceptable side-effects, potential drug-drug interactions (DDIs) or slow onset/lack of efficacy. The endogenous opioid system is involved in stress and emotion regulatory processes and its role in MDD has been implicated...
2016: Translational Perioperative and Pain Medicine
https://www.readbyqxmd.com/read/27182533/a-translational-consideration-of-intercellular-adhesion-molecule-1-biology-in-the-perioperative-setting
#14
Emily Greenwald, Koichi Yuki
Intercellular adhesion molecule-1 (ICAM-1) is a critical adhesion molecule involved in leukocyte recruitment. Since its discovery in 1986, a large number of studies have been performed to elucidate its role in vitro and in vivo. Here, we review its role in leukocyte recruitment and consider future steps to take that will enhance our understanding of ICAM-1 biology and its translational application in the perioperative setting.
2016: Translational Perioperative and Pain Medicine
https://www.readbyqxmd.com/read/26985446/opioid-system-modulates-the-immune-function-a-review
#15
Xuan Liang, Renyu Liu, Chunhua Chen, Fang Ji, Tianzuo Li
Opioid receptors and their ligands produce powerful analgesia that is effective in perioperative period and chronic pain managements accompanied with various side effects including respiratory depression, constipation and addiction etc. Opioids can also interfere with the immune system, not only participating in the function of the immune cells, but also modulating innate and acquired immune responses. The traditional notion of opioids is immunosuppressive. Recent studies indicate that the role of opioid receptors on immune function is complicated, working through various different mechanisms...
2016: Translational Perioperative and Pain Medicine
https://www.readbyqxmd.com/read/26301256/updated-mechanisms-of-sickle-cell-disease-associated-chronic-pain
#16
Brianna Lutz, Steffen E Meiler, Alex Bekker, Yuan-Xiang Tao
Sickle cell disease (SCD), a hemoglobinopathy, causes sickling of red blood cells, resulting in vessel blockage, stroke, anemia, inflammation, and extreme pain. A vast majority of SCD patients experience pain on a chronic basis, and many turn to opioids to provide limited relief. The side effects that come with chronic opioid use push for research into understanding the specific mechanisms of SCD-associated chronic pain. Current advances in SCD-associated pain have focused on alterations in the pain pathway including nociceptor sensitization and endogenous pain inducers...
July 26, 2015: Translational Perioperative and Pain Medicine
https://www.readbyqxmd.com/read/27135043/translational-medicine-a-multidisciplinary-collaborative-and-global-effort
#17
Wei Lu, Wuwei Feng
No abstract text is available yet for this article.
2015: Translational Perioperative and Pain Medicine
https://www.readbyqxmd.com/read/26413558/breastfeeding-after-anesthesia-a-review-for-anesthesia-providers-regarding-the-transfer-of-medications-into-breast-milk
#18
Benjamin Cobb, Renyu Liu, Elizabeth Valentine, Onyi Onuoha
Doctors, nurses, and midwives often inform mothers to "pump and dump" their breast milk for 24 hours after receiving anesthesia to avoid passing medications to the infant. This advice, though cautious, is probably outdated. This review highlights the more recent literature regarding common anesthesia medications, their passage into breast milk, and medication effects observed in breastfed infants. We suggest continuing breastfeeding after anesthesia when the mother is awake, alert, and able to hold her infant...
2015: Translational Perioperative and Pain Medicine
https://www.readbyqxmd.com/read/26366428/ketamine-a-multifaceted-drug
#19
Lingzhong Meng, Jian Li, Yi Lu, Dajin Sun, Yuan-Xiang Tao, Renyu Liu, Jin Jun Luo
There is a petition for tight control of ketamine from the Chinese government to classify ketamine as a Schedule I drug, which is defined as a drug with no currently accepted medical use but a high potential for abuse. However, ketamine has unique properties that can benefit different patient populations. Scholars from the Translational Perioperative and Pain Medicine and the International Chinese Academy of Anesthesiology WeChat groups had an interactive discussion on ketamine, including its current medical applications, future research priorities, and benefits versus risks...
2015: Translational Perioperative and Pain Medicine
https://www.readbyqxmd.com/read/26339682/intrathecal-rapamycin-attenuates-morphine-induced-analgesic-tolerance-and-hyperalgesia-in-rats-with-neuropathic-pain
#20
Ji-Tian Xu, Linlin Sun, Brianna Marie Lutz, Alex Bekker, Yuan-Xiang Tao
Repeated and long-term administration of opioids is often accompanied by the initiation of opioid-induced analgesic tolerance and hyperalgesia in chronic pain patients. Our previous studies showed that repeated intrathecal morphine injection activated the mammalian target of rapamycin complex 1 (mTORC1) in spinal dorsal horn neurons and that blocking this activation prevented the initiation of morphine-induced tolerance and hyperalgesia in healthy rats. However, whether spinal mTORC1 is required for morphine-induced tolerance and hyperalgesia under neuropathic pain conditions remains elusive...
2015: Translational Perioperative and Pain Medicine
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