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BMJ Open Respiratory Research

Jeffrey J Swigris
Patients with idiopathic pulmonary fibrosis (IPF) face a poor prognosis and endure intrusive symptoms that impair quality of life. Many patients with IPF will require supplemental oxygen (O2 ) at some point in the course of their illness, and although it can improve blood oxygen and symptoms, O2 creates physical and emotional challenges for patients and their loved ones. Four events in the course of IPF-the first occurs at the time of diagnosis and the other three are related to O2 -herald periods of transition for patients and their caregivers and mark touchpoints when they need extra care and support from practitioners...
2018: BMJ Open Respiratory Research
Maaike de Vries, Diana A van der Plaat, Judith M Vonk, H Marike Boezen
Introduction: Chronic obstructive pulmonary disease (COPD) is a progressive inflammatory lung disease with cigarette smoke as the main risk factor for its development. Since not every smoker develops COPD, other factors likely underlie differences in susceptibility to develop COPD. Here, we tested if DNA methylation may be such a factor by assessing the association between DNA methylation levels and COPD in never and current smokers from the general population. Methods: For the current study, 1561 subjects were non-randomly selected from the LifeLines cohort study...
2018: BMJ Open Respiratory Research
Brooks W Morgan, Matthew R Grigsby, Trishul Siddharthan, Robert Kalyesubula, Robert A Wise, John R Hurst, Bruce Kirenga, William Checkley
Introduction: Chronic obstructive pulmonary disease (COPD) will soon be the third leading global cause of death and is increasing rapidly in low/middle-income countries. There is a need for local validation of the Saint George's Respiratory Questionnaire (SGRQ), which can be used to identify those experiencing lifestyle impairment due to their breathing. Methods: The SGRQ was professionally translated into Luganda and reviewed by our field staff and a local pulmonologist...
2018: BMJ Open Respiratory Research
Alice Malpass, Gene Feder, James W Dodd
Introduction: Dyspnoea has been defined as a 'subjective experience of breathing discomfort that consists of qualitatively distinct sensations that vary in intensity'. However, the majority of available dyspnoea measures treat it as a single entity and rely on quantitative methodology. We propose that qualitative research can enhance our understanding of dyspnoea, in particular, how perception varies so much among patients with similar disease states. In this paper, we focus on how a specific type of inner attention-mindfulness-may alter perceptions of dyspnoea...
2018: BMJ Open Respiratory Research
Ákos Tényi, Emili Vela, Isaac Cano, Montserrat Cleries, David Monterde, David Gomez-Cabrero, Josep Roca
Introduction: Comorbidities in patients with chronic obstructive pulmonary disease (COPD) generate a major burden on healthcare. Identification of cost-effective strategies aiming at preventing and enhancing management of comorbid conditions in patients with COPD requires deeper knowledge on epidemiological patterns and on shared biological pathways explaining co-occurrence of diseases. Methods: The study assesses the co-occurrence of several chronic conditions in patients with COPD using two different datasets: Catalan Healthcare Surveillance System (CHSS) (ES, 1...
2018: BMJ Open Respiratory Research
Pia Hardelid, Melpo Kapetanstrataki, Lee Norman, Sarah J Fleming, Paula Lister, Ruth Gilbert, Roger C Parslow
Introduction: A universal childhood influenza vaccination programme was introduced in the UK in September 2013. We examine the impact of the gradual introduction of this programme on influenza-related paediatric intensive care unit (PICU) admission rates in England. Methods: We extracted data on all influenza-related admissions to PICUs in England in resident children aged 0-15 years old between October 2003 and March 2017 from the Paediatric Intensive Care Audit Network (PICANet) database...
2018: BMJ Open Respiratory Research
Luke S Howard, Steven Barden, Robin Condliffe, Vincent Connolly, Chris Davies, James Donaldson, Bernard Everett, Catherine Free, Daniel Horner, Laura Hunter, Jasvinder Kaler, Catherine Nelson-Piercy, Emma O'Dowd, Raj Patel, Wendy Preston, Karen Sheares, Campbell Tait
The following is a summary of the recommendations and good practice points for the BTS Guideline for the initial outpatient management of pulmonary embolism. Please refer to the full guideline for full information about each section.
2018: BMJ Open Respiratory Research
Sophan Sam, Adrienne E Shapiro, Thim Sok, Sokhan Khann, Rassi So, Sopheap Khem, Sokhem Chhun, Sarith Noun, Bonamy Koy, Prum Chhom Sayouen, Chun Im Sin, Heng Bunsieth, Tan Eang Mao, Anne E Goldfeld
Introduction: Prolonged inpatient multidrug-resistant tuberculosis (MDR-TB) treatment for all patients is not sustainable for high-burden settings, but there is limited information on community-based treatment programme outcomes for MDR-TB. Methods: The Cambodian Health Committee, a non-governmental organisation (NGO), launched the Cambodian MDR-TB programme in 2006 in cooperation with the National Tuberculosis Program (NTP) including a community-based treatment option as a key programme component...
2018: BMJ Open Respiratory Research
Erik H F M van der Heijden, Piero Candoli, Igor Vasilev, Alessandro Messi, Javier Pérez Pallarés, Piotr Yablonskii, Anna van der Vorm, Olga C J Schuurbiers, Wouter Hoefsloot
Introduction: Patients with lung cancer may present with additional lesions in the central airways. Earlier studies have shown a relationship between vessel diameter, pattern and grade of malignancy. High-definition (HD+) bronchoscopy with image enhancement techniques (i-scan) detected more vascular abnormalities but correlation with pathology has not yet been established. Methods: In this investigator-initiated, randomised, controlled, crossover, multicentre study in patients with suspected lung cancer, a HD+ bronchoscopy was performed with i-scan1 and i-scan2 settings in random order...
2018: BMJ Open Respiratory Research
Geoffrey A Martin, Selina Tsim, Andrew C Kidd, John E Foster, Philip McLoone, Anthony Chalmers, Kevin G Blyth
Introduction: Non-expansile lung (NEL) is a common cause of talc pleurodesis (TP) failure in malignant pleural effusion (MPE), but is often occult prior to drainage. Reliable detection of NEL would allow patients to be allocated between intrapleural catheter (IPC) and TP. High pleural elastance (PEL ) has been associated with NEL in observational studies. Pre-EDIT is a randomised feasibility trial of elastance-directed IPC or TP (EDIT) management using a novel, purpose-built digital pleural manometer (Rocket Medical, UK)...
2018: BMJ Open Respiratory Research
Jeffrey J Swigris, Hilary Wilson, Dirk Esser, Craig S Conoscenti, Wibke Stansen, Nancy Kline Leidy, Kevin K Brown
Introduction: We evaluated the psychometric properties of the St George's Respiratory Questionnaire (SGRQ) in patients with idiopathic pulmonary fibrosis (IPF) using data from the two INPULSIS trials. Methods: Data from 1061 patients treated with nintedanib or placebo were pooled. Internal consistency, test-retest reliability, construct validity, known-groups validity, responsiveness and responder thresholds were examined. Results: Cronbach's α was 0...
2018: BMJ Open Respiratory Research
Mehrdad Arjomandi, Siyang Zeng, Jeroen Geerts, Rachel K Stiner, Bruce Bos, Ian van Koeverden, Jason Keene, Brett Elicker, Paul D Blanc, Warren M Gold
Introduction: Exposure to secondhand smoke (SHS) is associated with occult obstructive lung disease as evident by abnormal airflow indices representing small airway disease despite having preserved spirometry (normal forced expiratory volume in 1 s-to-forced vital capacity ratio, FEV1 /FVC). The significance of lung volumes that reflect air trapping in the presence of preserved spirometry is unclear. Methods: To investigate whether lung volumes representing air trapping could determine susceptibility to respiratory morbidity in people with SHS exposure but without spirometric chronic obstructive pulmonary disease, we examined a cohort of 256 subjects with prolonged occupational SHS exposure and preserved spirometry...
2018: BMJ Open Respiratory Research
Tamar Anne Smith-Norowitz, Kobkul Chotikanatis, Diana Weaver, Jared Ditkowsky, Yitzchok Meir Norowitz, Margaret R Hammerschlag, Rauno Joks, Stephan Kohlhoff
Introduction: Chlamydia pneumoniae respiratory tract infection has been implicated in the pathogenesis of reactive airway disease and asthma. Innate cytokine responses that are protective of infection with intracellular pathogens may be impaired in patients with asthma. Tumour necrosis factor alpha (TNF-α) is a cytokine related to functions of monocytes and may inhibit C. pneumoniae infection. We investigated TNF-α responses in C. pneumoniae -infected peripheral blood mononuclear cells (PBMCs) in patients with asthma and non-asthma, and whether ciprofloxacin, azithromycin or doxycycline affects TNF-α responses...
2018: BMJ Open Respiratory Research
Daniel Franzen, Sarah R Haile, David C Kasper, Thomas P Mechtler, Andreas J Flammer, Pierre A Krayenbühl, Albina Nowak
Introduction: Anderson-Fabry disease (AFD) is an X-linked lysosomal storage disorder caused by mutations of GLA gene leading to reduced α-galactosidase activity and resulting in a progressive accumulation of globotriaosylceramide (Gb3) and its deacylated derivative, globotriaosyl-sphingosine (Lyso-Gb3). Plasma Lyso-Gb3 levels serve as a disease severity and treatment monitoring marker during enzyme replacement therapy (ERT). Methods: Adult patients with AFD who had yearly pulmonary function tests between 1999 and 2015 were eligible for this observational study...
2018: BMJ Open Respiratory Research
David Baldwin, Matthew Callister, Ahsan Akram, Paul Cane, Jeanette Draffan, Kevin Franks, Fergus Gleeson, Richard Graham, Puneet Malhotra, Philip Pearson, Manil Subesinghe, David Waller, Ian Woolhouse
Introduction: The purpose of the quality standards document is to provide healthcare professionals, commissioners, service providers and patients with a guide to standards of care that should be met for the investigation and management of pulmonary nodules in the UK, together with measurable markers of good practice. Methods: Development of British Thoracic Society (BTS) Quality Standards follows the BTS process of quality standard production based on the National Institute for Health and Care Excellence process manual for the development of quality standards...
2018: BMJ Open Respiratory Research
Michael Davies, Martin Allen, Andrew Bentley, Stephen C Bourke, Ben Creagh-Brown, Rachel D'Oliveiro, Alastair Glossop, Alasdair Gray, Phillip Jacobs, Ravi Mahadeva, Rachael Moses, Ian Setchfield
Introduction: The purpose of the quality standards document is to provide healthcare professionals, commissioners, service providers and patients with a guide to standards of care that should be met for the provision of acute non-invasive ventilation in adults together with measurable markers of good practice. Methods: Development of British Thoracic Society (BTS) Quality Standards follows the BTS process of quality standard production based on the National Institute for Health and Care Excellence process manual for the development of quality standards...
2018: BMJ Open Respiratory Research
Annabelle Bédard, Sarah J Lewis, Stephen Burgess, A John Henderson, Seif O Shaheen
Introduction: Limited evidence from birth cohort studies suggests that lower prenatal iron status may be a risk factor for childhood respiratory and atopic outcomes, but these observational findings may be confounded. Mendelian randomisation (MR) can potentially provide unconfounded estimates of causal effects by using common genetic variants as instrumental variables. We aimed to study the relationship between prenatal iron status and respiratory and atopic outcomes in the offspring using MR...
2018: BMJ Open Respiratory Research
(no author information available yet)
[This corrects the article DOI: 10.1136/bmjresp-2017-000252.].
2018: BMJ Open Respiratory Research
Duneesha de Fonseka, Wendy Underwood, Louise Stadon, Najib Rahman, Anthony Edey, Chris Rogers, Nick A Maskell
Introduction: Pleural malignancy, particularly malignant pleural mesothelioma (MPM) is increasing in incidence due to the long latency period from exposure to asbestos to development of the disease. MPM can be challenging to diagnose. For patients presenting without a pleural effusion, CT-guided biopsy remains the primary choice of biopsy, but the diagnostic sensitivity of this investigation is 70%-75%. Therefore, a proportion of patients will go on to require further biopsies. If the first biopsy is non-diagnostic, the chances of further non-diagnostic biopsies are high in MPM...
2018: BMJ Open Respiratory Research
James Farrell, Enrique Garrido
Introduction: High prevalence of obstructive lung disease has been reported in patients undergoing surgical correction of thoracic scoliosis. Airway narrowing due to spine morphology is analysed as a contributing factor. Methods: Preoperative surgical planning CTs of 34 patients with right-sided thoracic scoliosis (age: 17.6±9.0) were retrospectively analysed and compared with 15 non-scoliotic controls (age: 16.3±5.1). Three-dimensional models of spine and airway lumen were reconstructed...
2018: BMJ Open Respiratory Research
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