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BMJ Open Respiratory Research

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https://www.readbyqxmd.com/read/29225889/efficacy-of-sonographic-and-biological-pleurodesis-indicators-of-malignant-pleural-effusion-simple-protocol-of-a-randomised-controlled-trial
#1
Ioannis Psallidas, Hania E G Piotrowska, Ahmed Yousuf, Nikolaos I Kanellakis, Gayathri Kagithala, Seid Mohammed, Lei Clifton, John P Corcoran, Nicky Russell, Melissa Dobson, Robert F Miller, Najib M Rahman
Introduction: Malignant pleural effusion (MPE) is common and currently in UK there are an estimated 50 000 new cases of MPE per year. Talc pleurodesis remains one of the most popular methods for fluid control. The value of thoracic ultrasound (TUS) imaging, before and after pleurodesis, in improving the quality and efficacy of care for patients with MPE remains unknown. Additionally, biomarkers of successful pleurodesis including measurement of pleural fluid proteins have not been validated in prospective studies...
2017: BMJ Open Respiratory Research
https://www.readbyqxmd.com/read/29104754/poor-cough-flow-in-acute-stroke-patients-is-associated-with-reduced-functional-residual-capacity-and-low-cough-inspired-volume
#2
Katie Ward, Prashant Rao, Charles C Reilly, Gerrard Francis Rafferty, Michael I Polkey, Lalit Kalra, John Moxham
Introduction: Each year 7 million people die of stroke worldwide; most deaths are caused by chest infections. Patients with acute stroke have impaired voluntary cough flow, associated with increased risk of chest infections. Reduced functional residual capacity (FRC) could lead to impaired cough flow. We therefore compared FRC in acute hemiparetic stroke patients and controls and explored its relationship with volume inspired before cough and voluntary cough peak flow. Methods: 21 patients within 2 weeks of first-ever middle cerebral artery territory (MCA) infarct (mean (SD) age 68 (11) years, 10 females) and 30 controls (58 (11) years, 15 females) underwent FRC and voluntary cough testing (cough inspired volume and peak flow) while semirecumbent...
2017: BMJ Open Respiratory Research
https://www.readbyqxmd.com/read/29071086/alcohol-drinking-and-cigarette-smoking-in-relation-to-risk-of-active-tuberculosis-prospective-cohort-study
#3
Avril Zixin Soh, Cynthia Bin Eng Chee, Yee-Tang Wang, Jian-Min Yuan, Woon-Puay Koh
INTRODUCTION: Heavy alcohol consumption increases the risk of active tuberculosis (TB). However, the relation between lower levels of alcohol intake and TB risk remains unclear. We aimed to evaluate the association between alcohol intake and risk of active TB and assess whether the associations were modified by smoking status, which is another risk factor for active TB. METHODS: The Singapore Chinese Health Study is a prospective cohort of 63 257 adults aged 45-74 years recruited from 1993 to 1998...
2017: BMJ Open Respiratory Research
https://www.readbyqxmd.com/read/29071085/sputum-colour-can-identify-patients-with-neutrophilic-inflammation-in-asthma
#4
Kavita Pabreja, Peter Gibson, Alyssa J Lochrin, Lisa Wood, Katherine J Baines, Jodie L Simpson
INTRODUCTION: Sputum colour is associated with neutrophilic inflammation in chronic bronchitis and chronic obstructive pulmonary disease (COPD). Neutrophilia and sputum expectoration is notable in asthma, but whether sputum colour is associated with and predicts the presence of neutrophilic inflammation in asthma is unknown. The objective of the study is to assess the ability of sputum colour in distinguishing asthma inflammatory phenotypes. METHODS: Induced sputum samples collected from 271 adults with stable asthma were retrospectively assessed...
2017: BMJ Open Respiratory Research
https://www.readbyqxmd.com/read/29071084/are-within-person-numerical-rating-scale-nrs-ratings-of-breathlessness-on-average-valid-in-advanced-disease-for-patients-and-for-patients-informal-carers
#5
Joshua Wade, Silvia Mendonca, Sara Booth, Gail Ewing, A Carole Gardener, Morag Farquhar
INTRODUCTION: The Numerical Rating Scale (NRS) is frequently used to assess patient-reported breathlessness in both a research and clinical context. A subgroup of patients report average breathlessness as worse than their worst breathlessness in the last 24 hours (paradoxical average). The Peak/End rule describes how the most extreme and current breathlessness influence reported average. This study seeks to highlight the existence of a subpopulation who give 'paradoxical averages using the NRS, to characterise this group and to investigate the explanatory relevance of the 'Peak/End' rule...
2017: BMJ Open Respiratory Research
https://www.readbyqxmd.com/read/29071083/higher-bmi-is-associated-with-higher-expiratory-airflow-normalised-for-lung-volume-fef25-75-fvc-in-copd
#6
Eric Abston, Alejandro Comellas, Robert Michael Reed, Victor Kim, Robert A Wise, Roy Brower, Spyridon Fortis, Reinhard Beichel, Surya Bhatt, Joseph Zabner, John Newell, Eric A Hoffman, Michael Eberlein
INTRODUCTION: The obesity paradox in chronic obstructive pulmonary disease (COPD), whereby patients with higher body mass index (BMI) fare better, is poorly understood. Higher BMIs are associated with lower lung volumes and greater lung elastic recoil, a key determinant of expiratory airflow. The forced expiratory flow (25-75) (FEF25-75)/forced vital capacity (FVC) ratio reflects effort-independent expiratory airflow in the context of lung volume and could be modulated by BMI. METHODS: We analysed data from the COPDGene study, an observational study of 10 192 subjects, with at least a 10 pack-year smoking history...
2017: BMJ Open Respiratory Research
https://www.readbyqxmd.com/read/29071082/adjuncts-for-sputum-clearance-in-copd-clinical-consensus-versus-actual-use
#7
Ruth Barker, Anthony A Laverty, Nicholas S Hopkinson
INTRODUCTION: Oscillatory positive pressure devices (OPEP) can be used as adjuncts to improve sputum clearance in chronic obstructive pulmonary disease (COPD), though the evidence base is incomplete. The attitudes of physiotherapists towards these devices in the care of patients with COPD is unknown. In addition, actual use compared with the prescription of medications has not been studied. METHODS: We analysed English prescribing data, obtained from OpenPrescribing...
2017: BMJ Open Respiratory Research
https://www.readbyqxmd.com/read/29071081/lower-airways-inflammation-in-patients-with-ards-measured-using-endotracheal-aspirates-a-pilot-study
#8
Savino Spadaro, Iryna Kozhevnikova, Paolo Casolari, Paolo Ruggeri, Tiziana Bellini, Riccardo Ragazzi, Federica Barbieri, Elisabetta Marangoni, Gaetano Caramori, Carlo Alberto Volta
INTRODUCTION: Our knowledge of acute respiratory distress syndrome (ARDS) pathogenesis is incomplete. The goal of this pilot study is to investigate the feasibility of measuring lower airways inflammation in patients with ARDS using repeated endotracheal aspirates (ETAs). METHODS: ETAs were obtained within 24 hours by intensive care unit admission from 25 mechanically ventilated patients with ARDS and 10 of them underwent a second ETA within 96 hours after the first sampling...
2017: BMJ Open Respiratory Research
https://www.readbyqxmd.com/read/29071080/description-of-the-protocol-for-the-practical-study-a-randomised-controlled-trial-of-the-efficacy-and-safety-of-ics-laba-reliever-therapy-in-asthma
#9
James Fingleton, Jo Hardy, Christina Baggott, Janine Pilcher, Andrew Corin, Robert J Hancox, Matire Harwood, Mark Holliday, Helen K Reddel, Philippa Shirtcliffe, Suzanne Snively, Mark Weatherall, Richard Beasley
INTRODUCTION: In adult asthma, combination inhaled corticosteroid (ICS)/fast-onset long-acting beta agonist (LABA) used solely as reliever therapy may represent an effective and safe alternative to ICS maintenance and short-acting beta agonist (SABA) reliever therapy. OBJECTIVE: To compare the efficacy and safety of ICS/fast-onset LABA reliever therapy with ICS maintenance and SABA reliever therapy in adults with asthma. METHODS AND ANALYSIS: A 52-week, open-label, parallel group, multicentre, phase III randomised controlled trial with 1:1 randomisation to either budesonide/formoterol Turbuhaler 200/6 µg, one actuation as required for symptom relief, or budesonide Turbuhaler 200 µg, one actuation twice daily and terbutaline Turbuhaler 250 µg, two actuations as required for symptom relief...
2017: BMJ Open Respiratory Research
https://www.readbyqxmd.com/read/29071079/singing-for-lung-health-a-qualitative-assessment-of-a-british-lung-foundation-programme-for-group-leaders
#10
Adam Lewis, Phoene Cave, Nicholas S Hopkinson
INTRODUCTION: Singing for Lung Health (SLH) groups are an increasingly popular intervention for people with respiratory disease. There are limited data as to how these groups should be developed and run. We aimed to evaluate the experience of singing leaders both to assess the training provided by the British Lung Foundation (BLF) and to provide information to guide future development of programmes. METHODS: A convenience sample of 15 leaders who had received BLF SLH training participated in the BLF service evaluation...
2017: BMJ Open Respiratory Research
https://www.readbyqxmd.com/read/29071078/respiratory-symptoms-are-more-common-among-short-sleepers-independent-of-obesity
#11
Erla Björnsdóttir, Christer Janson, Eva Lindberg, Erna Sif Arnardottir, Bryndís Benediktsdóttir, Judith Garcia-Aymerich, Anne Elie Carsin, Francisco Gómez Real, Kjell Torén, Joachim Heinrich, Dennis Nowak, José Luis Sánchez-Ramos, Pascal Demoly, Sandra Dorado Arenas, Ramon Coloma Navarro, Vivi Schlünssen, Chantal Raherison, Debbie L Jarvis, Thorarinn Gislason
INTRODUCTION: Sleep length has been associated with obesity and various adverse health outcomes. The possible association of sleep length and respiratory symptoms has not been previously described. The aim of this study was to investigate the association between sleep length and respiratory symptoms and whether such an association existed independent of obesity. METHODS: This is a multicentre, cross-sectional, population-based study performed in 23 centres in 10 different countries...
2017: BMJ Open Respiratory Research
https://www.readbyqxmd.com/read/29071077/assessing-the-use-of-breathesmart%C3%A2-mobile-technology-in-adult-patients-with-asthma-a-remote-observational-study
#12
Emilie Melvin, Anna Cushing, Anne Tam, Ruri Kitada, Melissa Manice
INTRODUCTION: Non-adherence to asthma daily controller medications is a common problem, reported to be responsible for 60% of asthma-related hospitalisations. The mean level of adherence for asthma medications is estimated to be as low as 22%. Therefore, objective measurements of adherence to medicine are necessary. This virtual observational study is designed to measure the usability of an electronic monitoring device platform that measures adherence. Understanding how patients use the BreatheSmart mobile technology at home is essential to assess its feasibility as a solution to improve medication adherence...
2017: BMJ Open Respiratory Research
https://www.readbyqxmd.com/read/29071076/burden-of-bacterial-upper-respiratory-tract-pathogens-in-school-children-of-nepal
#13
Sangita Thapa, Shishir Gokhale, Annavarapu Laxminarasimha Sharma, Lokendra Bahadur Sapkota, Shamshul Ansari, Rajendra Gautam, Sony Shrestha, Puja Neopane
INTRODUCTION: Respiratory tract infections are one of the most common human infections in all age group and important cause of mortality and morbidity worldwide. Most bacterial upper respiratory tract infections are vaccine preventable. This study aimed to determine the prevalence of carrier state of bacterial upper respiratory tract pathogens among school children. It also aimed to study their antibiograms. METHODS: The specimen from posterior pharyngeal wall and tonsils were collected from 204 participants on calcium alginate coated swabs (HiMedia)...
2017: BMJ Open Respiratory Research
https://www.readbyqxmd.com/read/29071075/evaluation-by-various-methods-of-the-physiological-mechanism-of-a-high-flow-nasal-cannula-hfnc-in-healthy-volunteers
#14
Miyuki Okuda, Nobuya Tanaka, Kazuyuki Naito, Takao Kumada, Koji Fukuda, Yuto Kato, Yuto Kido, Yutaro Okuda, Ryuji Nohara
INTRODUCTION: Several reports have described the usefulness of a high-flow nasal cannula (HFNC). However, the physiological mechanisms of this system are unclear. In the current study, various methods were used to investigate the physiological mechanisms of an HFNC in healthy volunteers. METHODS: The physiological mechanisms of the constant-flow and constant-pressure models of HFNC were studied in 10 healthy volunteers by the oesophageal balloon method, the electrical impedance method and the forced oscillation technique (FOT)...
2017: BMJ Open Respiratory Research
https://www.readbyqxmd.com/read/29071074/long-term-outcomes-of-patients-with-pulmonary-arteriovenous-malformations-considered-for-lung-transplantation-compared-with-similarly-hypoxaemic-cohorts
#15
Claire L Shovlin, Elisabetta Buscarini, J Michael B Hughes, David J Allison, James E Jackson
INTRODUCTION: Pulmonary arteriovenous malformations (PAVMs) may not be amenable to treatment by embolisation or surgical resection, and many patients are left with significant hypoxaemia. Lung transplantation has been undertaken. There is no guidance on selection criteria. METHODS: To guide transplantation listing assessments, the outcomes of the six patients who had been considered for transplantation were compared with a similarly hypoxaemic patient group recruited prospectively between 2005 and 2016 at the same UK institution...
2017: BMJ Open Respiratory Research
https://www.readbyqxmd.com/read/29071073/rapid-decline-in-lung-function-in-healthy-adults-predicts-incident-excess-urinary-albumin-excretion-later-in-life
#16
Sapna Bhatia, Clifford Qualls, Thomas A Crowell, Alexander Arynchyn, Bharat Thyagarajan, Lewis J Smith, Ravi Kalhan, David R Jacobs, Holly Kramer, Daniel Duprez, Bartolome Celli, Akshay Sood
INTRODUCTION: Chronic lung disease, often characterised by rapid decline in lung function, is associated with vascular endothelial dysfunction (characterised by moderate to severe excess urinary albumin excretion (eUAE) but their longitudinal relationship is inadequately studied. In a bidirectional longitudinal examination of healthy adults, we analysed the following two hypotheses: (1) rapid decline (ie, highest tertile of lung function decline) predicts eUAE and (2) eUAE predicts rapid decline...
2017: BMJ Open Respiratory Research
https://www.readbyqxmd.com/read/29071072/effect-of-high-flow-nasal-therapy-during-acute-aerobic-exercise-in-patients-with-chronic-obstructive-pulmonary-disease-after-exacerbation-protocol-for-a-randomised-controlled-cross-over-trial
#17
Guillaume Prieur, Clement Medrinal, Yann Combret, Aurora Robledo Quesada, Fabrice Prieur, Jean Quieffin, Jean Christian Borel, Gregory Reychler
INTRODUCTION: Early pulmonary rehabilitation is recommended after a severe exacerbation of chronic obstructive pulmonary disease (COPD). However, this is difficult to implement, particularly for exercise training. High-flow nasal therapy (HFNT) may reduce the work of breathing and dyspnoea and may improve exercise tolerance. METHODS AND ANALYSIS: This is a single-centre, prospective, controlled, randomised, cross-over study. Eligible patients will have a diagnosis of COPD (postbronchodilator forced expiratory volume in 1 s/forced vital capacity ratio of <0...
2017: BMJ Open Respiratory Research
https://www.readbyqxmd.com/read/29071071/environmental-triggers-of-copd-symptoms-a-case-cross-over-study
#18
Susan R Sama, David Kriebel, Rebecca J Gore, Rebecca DeVries, Richard Rosiello
INTRODUCTION: This study investigated the hypothesis that common environmental chemical exposures with known irritant or sensitising properties trigger exacerbations for patients with chronic obstructive pulmonary disease (COPD). METHODS: We conducted a case cross-over study in 168 patients with COPD who were members of a disease management group in central Massachusetts. Participants completed a baseline health survey and several short exposure surveys. Exposure surveys were administered by a nurse when a participant telephoned to report an exacerbation (case periods) and at a maximum of three randomly identified control periods when they were not experiencing an exacerbation...
2017: BMJ Open Respiratory Research
https://www.readbyqxmd.com/read/29018528/correction-evaluation-of-the-current-landscape-of-respiratory-nurse-specialists-in-the-uk-planning-for-the-future-needs-of-patients
#19
(no author information available yet)
[This corrects the article DOI: 10.1136/bmjresp-2017-000210.][This corrects the article DOI: 10.1136/bmjresp-2017-000210.].
2017: BMJ Open Respiratory Research
https://www.readbyqxmd.com/read/29018527/british-thoracic-society-quality-standards-for-home-oxygen-use-in-adults
#20
Jay Suntharalingam, Tom Wilkinson, Joseph Annandale, Claire Davey, Rhea Fielding, Daryl Freeman, Michael Gibbons, Maxine Hardinge, Sabrine Hippolyte, Vikki Knowles, Cassandra Lee, William MacNee, Jacqueline Pollington, Vandana Vora, Trefor Watts, Meme Wijesinghe
INTRODUCTION: The purpose of the quality standards document is to provide healthcare professionals, commissioners, service providers and patients with a guide to standards of care that should be met for home oxygen provision in the UK, together with measurable markers of good practice. Quality statements are based on the British Thoracic Society (BTS) Guideline for Home Oxygen Use in Adults. METHODS: Development of BTS Quality Standards follows the BTS process of quality standard production based on the National Institute for Health and Care Excellence process manual for the development of quality standards...
2017: BMJ Open Respiratory Research
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