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BMJ Open Respiratory Research

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https://www.readbyqxmd.com/read/29636979/british-thoracic-society-quality-standards-for-acute-non-invasive-ventilation-in-adults
#1
Michael Davies, Martin Allen, Andrew Bentley, Stephen C Bourke, Ben Creagh-Brown, Rachel D'Oliveiro, Alastair Glossop, Alasdair Gray, Phillip Jacobs, Ravi Mahadeva, Rachael Moses, Ian Setchfield
Introduction: The purpose of the quality standards document is to provide healthcare professionals, commissioners, service providers and patients with a guide to standards of care that should be met for the provision of acute non-invasive ventilation in adults together with measurable markers of good practice. Methods: Development of British Thoracic Society (BTS) Quality Standards follows the BTS process of quality standard production based on the National Institute for Health and Care Excellence process manual for the development of quality standards...
2018: BMJ Open Respiratory Research
https://www.readbyqxmd.com/read/29636978/maternal-iron-status-during-pregnancy-and-respiratory-and-atopic-outcomes-in-the-offspring-a-mendelian-randomisation-study
#2
Annabelle Bédard, Sarah J Lewis, Stephen Burgess, A John Henderson, Seif O Shaheen
Introduction: Limited evidence from birth cohort studies suggests that lower prenatal iron status may be a risk factor for childhood respiratory and atopic outcomes, but these observational findings may be confounded. Mendelian randomisation (MR) can potentially provide unconfounded estimates of causal effects by using common genetic variants as instrumental variables. We aimed to study the relationship between prenatal iron status and respiratory and atopic outcomes in the offspring using MR...
2018: BMJ Open Respiratory Research
https://www.readbyqxmd.com/read/29617009/correction-differentiation-of-quantitative-ct-imaging-phenotypes-in-asthma-versus-copd
#3
(no author information available yet)
[This corrects the article DOI: 10.1136/bmjresp-2017-000252.].
2018: BMJ Open Respiratory Research
https://www.readbyqxmd.com/read/29616141/randomised-controlled-trial-to-compare-the-diagnostic-yield-of-positron-emission-tomography-ct-pet-ct-targeted-pleural-biopsy-versus-ct-guided-pleural-biopsy-in-suspected-pleural-malignancy-target-trial
#4
Duneesha de Fonseka, Wendy Underwood, Louise Stadon, Najib Rahman, Anthony Edey, Chris Rogers, Nick A Maskell
Introduction: Pleural malignancy, particularly malignant pleural mesothelioma (MPM) is increasing in incidence due to the long latency period from exposure to asbestos to development of the disease. MPM can be challenging to diagnose. For patients presenting without a pleural effusion, CT-guided biopsy remains the primary choice of biopsy, but the diagnostic sensitivity of this investigation is 70%-75%. Therefore, a proportion of patients will go on to require further biopsies. If the first biopsy is non-diagnostic, the chances of further non-diagnostic biopsies are high in MPM...
2018: BMJ Open Respiratory Research
https://www.readbyqxmd.com/read/29616140/effect-of-idiopathic-thoracic-scoliosis-on-the-tracheobronchial-tree
#5
James Farrell, Enrique Garrido
Introduction: High prevalence of obstructive lung disease has been reported in patients undergoing surgical correction of thoracic scoliosis. Airway narrowing due to spine morphology is analysed as a contributing factor. Methods: Preoperative surgical planning CTs of 34 patients with right-sided thoracic scoliosis (age: 17.6±9.0) were retrospectively analysed and compared with 15 non-scoliotic controls (age: 16.3±5.1). Three-dimensional models of spine and airway lumen were reconstructed...
2018: BMJ Open Respiratory Research
https://www.readbyqxmd.com/read/29531748/randomised-clinical-trial-of-an-early-palliative-care-intervention-support-for-patients-with-idiopathic-pulmonary-fibrosis-ipf-and-their-caregivers-protocol-and-key-design-considerations
#6
Kathleen Oare Lindell, Mehdi Nouraie, Melinda J Klesen, Sara Klein, Kevin F Gibson, Daniel J Kass, Margaret Quinn Rosenzweig
Introduction: Idiopathic pulmonary fibrosis (IPF), a progressive life-limiting lung disease affects approximately 128 000 newly diagnosed individuals in the USA annually. IPF, a disease of ageing associated with intense medical and financial burden, is expected to grow in incidence globally. Median survival from diagnosis is 3.8 years, and many of these patients succumb to a rapid death within 6 months. Despite the fatal prognosis, we have found that patients and caregivers often fail to understand the poor prognosis as the disease relentlessly progresses...
2018: BMJ Open Respiratory Research
https://www.readbyqxmd.com/read/29531747/patterns-and-management-of-chronic-obstructive-pulmonary-disease-in-urban-and-rural-china-a-community-based-survey-of-25-000-adults-across-10-regions
#7
Om P Kurmi, Kourtney J Davis, Kin Bong Hubert Lam, Yu Guo, Julien Vaucher, Derrick Bennett, Jenny Wang, Zheng Bian, Huaidong Du, Liming Li, Robert Clarke, Zhengming Chen
Introduction: Chronic obstructive pulmonary disease (COPD) is the third leading cause of death worldwide, with COPD deaths in China accounting for one-third of all such deaths. However, there is limited available evidence on the management of COPD in China. Methods: A random sample of 25 011 participants in the China Kadoorie Biobank, aged 38-87 years, from 10 regions in China was surveyed in 2013-2014. Data were collected using interviewer-administered questionnaires on the diagnosis ('doctor-diagnosed' or 'symptoms-based') and management of COPD (including use of medication and other healthcare resources), awareness of diagnosis and severity of symptoms in COPD cases...
2018: BMJ Open Respiratory Research
https://www.readbyqxmd.com/read/29531746/bts-guideline-for-the-investigation-and-management-of-malignant-pleural-mesothelioma
#8
Ian Woolhouse, Lesley Bishop, Liz Darlison, Duneesha de Fonseka, Anthony Edey, John Edwards, Corinne Faivre-Finn, Dean A Fennell, Steve Holmes, Keith M Kerr, Apostolos Nakas, Tim Peel, Najib M Rahman, Mark Slade, Jeremy Steele, Selina Tsim, Nick A Maskell
The full guideline for the investigation and management of malignant pleural mesothelioma is published in Thorax . The following is a summary of the recommendations and good practice points. The sections referred to in the summary refer to the full guideline.
2018: BMJ Open Respiratory Research
https://www.readbyqxmd.com/read/29531745/symptom-severity-and-its-effect-on-health-related-quality-of-life-over-time-in-patients-with-pulmonary-hypertension-a-multisite-longitudinal-cohort-study
#9
Janelle Yorke, Christi Deaton, Malcolm Campbell, Linda McGowen, Paul Sephton, David G Kiely, Iain Armstrong
Introduction: The aim of this cohort study was to examine health-related quality of life (HRQoL) and symptomatology in patients with pulmonary hypertension (PH) and explore factors that influence its evolution over time. Methods: A prospective longitudinal multisite cohort study. Participants were recruited from specialist UK PH centres and completed a questionnaire pack at baseline, 6, 12 and 18 months to assess HRQoL (emPHasis-10), dyspnoea, fatigue, sleep, anxiety and depression...
2018: BMJ Open Respiratory Research
https://www.readbyqxmd.com/read/29531744/is-childhood-wheeze-and-asthma-in-latin-america-associated-with-poor-hygiene-and-infection-a-systematic-review
#10
Cristina Ardura-Garcia, Paul Garner, Philip J Cooper
Introduction: High asthma prevalence in Latin-American cities is thought to be caused by poor hygiene and infections. This contradicts the widely accepted 'hygiene hypothesis' for asthma aetiology. Methods: Systematic review of observational studies evaluating the association between poor hygiene exposures or infections and asthma/wheeze among Latin-American children aged 4-16 years. MEDLINE, EMBASE, LILACS and CINAHL electronic databases were searched following a predefined strategy to 18 December 2017...
2018: BMJ Open Respiratory Research
https://www.readbyqxmd.com/read/29531743/using-domiciliary-non-invasive-ventilator-data-downloads-to-inform-clinical-decision-making-to-optimise-ventilation-delivery-and-patient-compliance
#11
Stephanie K Mansell, Steven Cutts, Isobel Hackney, Martin J Wood, Kevin Hawksworth, Dean D Creer, Cherry Kilbride, Swapna Mandal
Introduction: Ventilation parameter data from patients receiving home mechanical ventilation can be collected via secure data cards and modem technology. This can then be reviewed by clinicians and ventilator prescriptions adjusted. Typically available measures include tidal volume (VT ), leak, respiratory rate, minute ventilation, patient triggered breaths, achieved pressures and patient compliance. This study aimed to assess the potential impact of ventilator data downloads on management of patients requiring home non-invasive ventilation (NIV)...
2018: BMJ Open Respiratory Research
https://www.readbyqxmd.com/read/29468074/development-of-a-patient-centred-evidence-based-and-consensus-based-discharge-care-bundle-for-patients-with-acute-exacerbation-of-chronic-obstructive-pulmonary-disease
#12
Maria B Ospina, Marta Michas, Lesly Deuchar, Richard Leigh, Mohit Bhutani, Brian H Rowe, Darcy Marciniuk, Donna Goodridge, Gail Dechman, Jean Bourbeau, Meyer Balter, Pat Camp, Paul Hernandez, Roger S Goldstein, Michael K Stickland
Introduction: Hospital and emergency department discharge for patients with chronic obstructive pulmonary disease (COPD) is often poorly organised. We developed a patient-centred, evidence-based and consensus-based discharge care bundle for patients with acute exacerbations of COPD. Methods: A purposeful sample of clinicians and patients were invited to participate in a two-round Delphi study (July-November 2015). In round 1, participants rated on a seven-point Likert scale (1=not at all important; 7=extremely important) the importance of 29 unique COPD care actions...
2018: BMJ Open Respiratory Research
https://www.readbyqxmd.com/read/29468073/survival-prediction-in-mesothelioma-using-a-scalable-lasso-regression-model-instructions-for-use-and-initial-performance-using-clinical-predictors
#13
Andrew C Kidd, Michael McGettrick, Selina Tsim, Daniel L Halligan, Max Bylesjo, Kevin G Blyth
Introduction: Accurate prognostication is difficult in malignant pleural mesothelioma (MPM). We developed a set of robust computational models to quantify the prognostic value of routinely available clinical data, which form the basis of published MPM prognostic models. Methods: Data regarding 269 patients with MPM were allocated to balanced training (n=169) and validation sets (n=100). Prognostic signatures (minimal length best performing multivariate trained models) were generated by least absolute shrinkage and selection operator regression for overall survival (OS), OS <6 months and OS <12 months...
2018: BMJ Open Respiratory Research
https://www.readbyqxmd.com/read/29387422/chronic-obstructive-pulmonary-disease-associated-with-biomass-fuel-use-in-women-a-systematic-review-and-meta-analysis
#14
Adama Sana, Serge M A Somda, Nicolas Meda, Catherine Bouland
Introduction: Chronic obstructive pulmonary disease (COPD) is a major and growing cause of morbidity and mortality worldwide. The global prevalence of COPD is growing faster in women than in men. Women are often exposed to indoor pollutants produced by biomass fuels burning during household activities. Methods: We conducted a meta-analysis to establish the association between COPD and exposure to biomass smoke in women.Following Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, we searched MEDLINE and Scopus databases in 31December 2016, with the terms: "wood", "charcoal", "biomass", "solid fuels", "organic fuel", "biofuel", "female", "women", "COPD", "chronic bronchitis", "emphysema", "chronic obstructive pulmonary disease"...
2018: BMJ Open Respiratory Research
https://www.readbyqxmd.com/read/29387421/reasons-for-accident-and-emergency-department-attendance-by-people-with-chronic-obstructive-pulmonary-disease-or-heart-failure-recipients-and-providers-perspectives-an-exploratory-study
#15
Jeong Su Lee, Heidi Lempp, Vivek Srivastava, Elizabeth Barley
Introduction: Fifteen million people are affected by one or more long-term conditions in England. The cost of caring for this patient group increases every year. Several studies have been conducted to find out why people with those conditions choose to access Accident and Emergency (A&E) frequently. To our knowledge, there is no study that compares the three groups (patients, family members and hospital clinicians), and this approach may enhance understanding of A&E admissions in England...
2018: BMJ Open Respiratory Research
https://www.readbyqxmd.com/read/29333271/childhood-asthma-prevalence-cross-sectional-record-linkage-study-comparing-parent-reported-wheeze-with-general-practitioner-recorded-asthma-diagnoses-from-primary-care-electronic-health-records-in-wales
#16
Lucy J Griffiths, Ronan A Lyons, Amrita Bandyopadhyay, Karen S Tingay, Suzanne Walton, Mario Cortina-Borja, Ashley Akbari, Helen Bedford, Carol Dezateux
Introduction: Electronic health records (EHRs) are increasingly used to estimate the prevalence of childhood asthma. The relation of these estimates to those obtained from parent-reported wheezing suggestive of asthma is unclear. We hypothesised that parent-reported wheezing would be more prevalent than general practitioner (GP)-recorded asthma diagnoses in preschool-aged children. Methods: 1529 of 1840 (83%) Millennium Cohort Study children registered with GPs in the Welsh Secure Anonymised Information Linkage databank were linked...
2018: BMJ Open Respiratory Research
https://www.readbyqxmd.com/read/29449949/british-thoracic-society-guideline-for-the-management-of-non-tuberculous-mycobacterial-pulmonary-disease-ntm-pd
#17
REVIEW
Charles S Haworth, John Banks, Toby Capstick, Andrew J Fisher, Thomas Gorsuch, Ian F Laurenson, Andrew Leitch, Michael R Loebinger, Heather J Milburn, Mark Nightingale, Peter Ormerod, Delane Shingadia, David Smith, Nuala Whitehead, Robert Wilson, R Andres Floto
The full guideline for the management of non-tuberculous mycobacterial pulmonary disease is published in Thorax . The following is a summary of the recommendations and good practice points. The sections referred to in the summary refer to the full guideline.
2017: BMJ Open Respiratory Research
https://www.readbyqxmd.com/read/29441206/endobronchial-valves-for-emphysema-an-individual-patient-level-reanalysis-of-randomised-controlled-trials
#18
Karin Klooster, Dirk-Jan Slebos, Zaid Zoumot, Claire Davey, Pallav L Shah, Nicholas S Hopkinson
Introduction: Endobronchial valve placement has potential as a treatment for patients with chronic obstructive pulmonary disease (COPD). However, a robust evidence base will be needed to convince commissioners of healthcare that it is a high-value treatment. We sought to develop the evidence base by performing an individual patient-level analysis of randomised controlled trials in people with heterogeneous emphysema and an absence of collateral ventilation. Methods: A literature search (PROSPERO register CRD42016048127) identified two trials meeting these criteria, the BelieVeR-HIFi and STELVIO studies...
2017: BMJ Open Respiratory Research
https://www.readbyqxmd.com/read/29435346/effect-of-anti-podoplanin-antibody-administration-during-lipopolysaccharide-induced-lung-injury-in-mice
#19
Sian Lax, Julie Rayes, David R Thickett, Steve P Watson
Introduction: Acute respiratory distress syndrome (ARDS) is a devastating pulmonary condition in the critically ill patient. A therapeutic intervention is yet to be found that can prevent progression to ARDS. We recently demonstrated that the interaction between podoplanin expressed on inflammatory alveolar macrophages (iAMs) and its endogenous ligand, platelet C-type lectin-like 2 (CLEC-2), protects against exaggerated lung inflammation during a mouse model of ARDS. In this study, we aim to investigate the therapeutic use of a crosslinking/activating anti-podoplanin antibody (α-PDPN, clone 8...
2017: BMJ Open Respiratory Research
https://www.readbyqxmd.com/read/29435345/differentiation-of-quantitative-ct-imaging-phenotypes-in-asthma-versus-copd
#20
Sanghun Choi, Babak Haghighi, Jiwoong Choi, Eric A Hoffman, Alejandro P Comellas, John D Newell, Sally E Wenzel, Mario Castro, Sean B Fain, Nizar N Jarjour, Mark L Schiebler, R Graham Barr, MeiLan K Han, Eugene R Bleecker, Christopher B Cooper, David Couper, Nadia Hansel, Richard E Kanner, Ella A Kazeroni, Eric A C Kleerup, Fernando J Martinez, Wanda K O'Neal, Prescott G Woodruff, Ching-Long Lin
Introduction: Quantitative CT (QCT) imaging-based metrics have quantified disease alterations in asthma and chronic obstructive pulmonary disease (COPD), respectively. We seek to characterise the similarity and disparity between these groups using QCT-derived airway and parenchymal metrics. Methods: Asthma and COPD subjects (former-smoker status) were selected with a criterion of post-bronchodilator FEV1 <80%. Healthy non-smokers were included as a control group...
2017: BMJ Open Respiratory Research
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