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BMJ Open Respiratory Research

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https://www.readbyqxmd.com/read/29862031/image-enhancement-technology-in-bronchoscopy-a-prospective-multicentre-study-in-lung-cancer
#1
Erik H F M van der Heijden, Piero Candoli, Igor Vasilev, Alessandro Messi, Javier Pérez Pallarés, Piotr Yablonskii, Anna van der Vorm, Olga C J Schuurbiers, Wouter Hoefsloot
Introduction: Patients with lung cancer may present with additional lesions in the central airways. Earlier studies have shown a relationship between vessel diameter, pattern and grade of malignancy. High-definition (HD+) bronchoscopy with image enhancement techniques (i-scan) detected more vascular abnormalities but correlation with pathology has not yet been established. Methods: In this investigator-initiated, randomised, controlled, crossover, multicentre study in patients with suspected lung cancer, a HD+ bronchoscopy was performed with i-scan1 and i-scan2 settings in random order...
2018: BMJ Open Respiratory Research
https://www.readbyqxmd.com/read/29862030/pre-edit-protocol-for-a-randomised-feasibility-trial-of-elastance-directed-intrapleural-catheter-or-talc-pleurodesis-edit-in-malignant-pleural-effusion
#2
Geoffrey A Martin, Selina Tsim, Andrew C Kidd, John E Foster, Philip McLoone, Anthony Chalmers, Kevin G Blyth
Introduction: Non-expansile lung (NEL) is a common cause of talc pleurodesis (TP) failure in malignant pleural effusion (MPE), but is often occult prior to drainage. Reliable detection of NEL would allow patients to be allocated between intrapleural catheter (IPC) and TP. High pleural elastance (PEL ) has been associated with NEL in observational studies. Pre-EDIT is a randomised feasibility trial of elastance-directed IPC or TP (EDIT) management using a novel, purpose-built digital pleural manometer (Rocket Medical, UK)...
2018: BMJ Open Respiratory Research
https://www.readbyqxmd.com/read/29862029/psychometric-properties-of-the-st-george-s-respiratory-questionnaire-in-patients-with-idiopathic-pulmonary-fibrosis-insights-from-the-inpulsis-trials
#3
Jeffrey J Swigris, Hilary Wilson, Dirk Esser, Craig S Conoscenti, Wibke Stansen, Nancy Kline Leidy, Kevin K Brown
Introduction: We evaluated the psychometric properties of the St George's Respiratory Questionnaire (SGRQ) in patients with idiopathic pulmonary fibrosis (IPF) using data from the two INPULSIS trials. Methods: Data from 1061 patients treated with nintedanib or placebo were pooled. Internal consistency, test-retest reliability, construct validity, known-groups validity, responsiveness and responder thresholds were examined. Results: Cronbach's α was 0...
2018: BMJ Open Respiratory Research
https://www.readbyqxmd.com/read/29755755/lung-volumes-identify-an-at-risk-group-in-persons-with-prolonged-secondhand-tobacco-smoke-exposure-but-without-overt-airflow-obstruction
#4
Mehrdad Arjomandi, Siyang Zeng, Jeroen Geerts, Rachel K Stiner, Bruce Bos, Ian van Koeverden, Jason Keene, Brett Elicker, Paul D Blanc, Warren M Gold
Introduction: Exposure to secondhand smoke (SHS) is associated with occult obstructive lung disease as evident by abnormal airflow indices representing small airway disease despite having preserved spirometry (normal forced expiratory volume in 1 s-to-forced vital capacity ratio, FEV1 /FVC). The significance of lung volumes that reflect air trapping in the presence of preserved spirometry is unclear. Methods: To investigate whether lung volumes representing air trapping could determine susceptibility to respiratory morbidity in people with SHS exposure but without spirometric chronic obstructive pulmonary disease, we examined a cohort of 256 subjects with prolonged occupational SHS exposure and preserved spirometry...
2018: BMJ Open Respiratory Research
https://www.readbyqxmd.com/read/29755754/-chlamydia-pneumoniae-induced-tumour-necrosis-factor-alpha-responses-are-lower-in-children-with-asthma-compared-with-non-asthma
#5
Tamar Anne Smith-Norowitz, Kobkul Chotikanatis, Diana Weaver, Jared Ditkowsky, Yitzchok Meir Norowitz, Margaret R Hammerschlag, Rauno Joks, Stephan Kohlhoff
Introduction: Chlamydia pneumoniae respiratory tract infection has been implicated in the pathogenesis of reactive airway disease and asthma. Innate cytokine responses that are protective of infection with intracellular pathogens may be impaired in patients with asthma. Tumour necrosis factor alpha (TNF-α) is a cytokine related to functions of monocytes and may inhibit C. pneumoniae infection. We investigated TNF-α responses in C. pneumoniae -infected peripheral blood mononuclear cells (PBMCs) in patients with asthma and non-asthma, and whether ciprofloxacin, azithromycin or doxycycline affects TNF-α responses...
2018: BMJ Open Respiratory Research
https://www.readbyqxmd.com/read/29713479/pulmonary-involvement-in-fabry-disease-effect-of-plasma-globotriaosylsphingosine-and-time-to-initiation-of-enzyme-replacement-therapy
#6
Daniel Franzen, Sarah R Haile, David C Kasper, Thomas P Mechtler, Andreas J Flammer, Pierre A Krayenbühl, Albina Nowak
Introduction: Anderson-Fabry disease (AFD) is an X-linked lysosomal storage disorder caused by mutations of GLA gene leading to reduced α-galactosidase activity and resulting in a progressive accumulation of globotriaosylceramide (Gb3) and its deacylated derivative, globotriaosyl-sphingosine (Lyso-Gb3). Plasma Lyso-Gb3 levels serve as a disease severity and treatment monitoring marker during enzyme replacement therapy (ERT). Methods: Adult patients with AFD who had yearly pulmonary function tests between 1999 and 2015 were eligible for this observational study...
2018: BMJ Open Respiratory Research
https://www.readbyqxmd.com/read/29682290/british-thoracic-society-quality-standards-for-the-investigation-and-management-of-pulmonary-nodules
#7
David Baldwin, Matthew Callister, Ahsan Akram, Paul Cane, Jeanette Draffan, Kevin Franks, Fergus Gleeson, Richard Graham, Puneet Malhotra, Philip Pearson, Manil Subesinghe, David Waller, Ian Woolhouse
Introduction: The purpose of the quality standards document is to provide healthcare professionals, commissioners, service providers and patients with a guide to standards of care that should be met for the investigation and management of pulmonary nodules in the UK, together with measurable markers of good practice. Methods: Development of British Thoracic Society (BTS) Quality Standards follows the BTS process of quality standard production based on the National Institute for Health and Care Excellence process manual for the development of quality standards...
2018: BMJ Open Respiratory Research
https://www.readbyqxmd.com/read/29636979/british-thoracic-society-quality-standards-for-acute-non-invasive-ventilation-in-adults
#8
Michael Davies, Martin Allen, Andrew Bentley, Stephen C Bourke, Ben Creagh-Brown, Rachel D'Oliveiro, Alastair Glossop, Alasdair Gray, Phillip Jacobs, Ravi Mahadeva, Rachael Moses, Ian Setchfield
Introduction: The purpose of the quality standards document is to provide healthcare professionals, commissioners, service providers and patients with a guide to standards of care that should be met for the provision of acute non-invasive ventilation in adults together with measurable markers of good practice. Methods: Development of British Thoracic Society (BTS) Quality Standards follows the BTS process of quality standard production based on the National Institute for Health and Care Excellence process manual for the development of quality standards...
2018: BMJ Open Respiratory Research
https://www.readbyqxmd.com/read/29636978/maternal-iron-status-during-pregnancy-and-respiratory-and-atopic-outcomes-in-the-offspring-a-mendelian-randomisation-study
#9
Annabelle Bédard, Sarah J Lewis, Stephen Burgess, A John Henderson, Seif O Shaheen
Introduction: Limited evidence from birth cohort studies suggests that lower prenatal iron status may be a risk factor for childhood respiratory and atopic outcomes, but these observational findings may be confounded. Mendelian randomisation (MR) can potentially provide unconfounded estimates of causal effects by using common genetic variants as instrumental variables. We aimed to study the relationship between prenatal iron status and respiratory and atopic outcomes in the offspring using MR...
2018: BMJ Open Respiratory Research
https://www.readbyqxmd.com/read/29617009/correction-differentiation-of-quantitative-ct-imaging-phenotypes-in-asthma-versus-copd
#10
(no author information available yet)
[This corrects the article DOI: 10.1136/bmjresp-2017-000252.].
2018: BMJ Open Respiratory Research
https://www.readbyqxmd.com/read/29616141/randomised-controlled-trial-to-compare-the-diagnostic-yield-of-positron-emission-tomography-ct-pet-ct-targeted-pleural-biopsy-versus-ct-guided-pleural-biopsy-in-suspected-pleural-malignancy-target-trial
#11
Duneesha de Fonseka, Wendy Underwood, Louise Stadon, Najib Rahman, Anthony Edey, Chris Rogers, Nick A Maskell
Introduction: Pleural malignancy, particularly malignant pleural mesothelioma (MPM) is increasing in incidence due to the long latency period from exposure to asbestos to development of the disease. MPM can be challenging to diagnose. For patients presenting without a pleural effusion, CT-guided biopsy remains the primary choice of biopsy, but the diagnostic sensitivity of this investigation is 70%-75%. Therefore, a proportion of patients will go on to require further biopsies. If the first biopsy is non-diagnostic, the chances of further non-diagnostic biopsies are high in MPM...
2018: BMJ Open Respiratory Research
https://www.readbyqxmd.com/read/29616140/effect-of-idiopathic-thoracic-scoliosis-on-the-tracheobronchial-tree
#12
James Farrell, Enrique Garrido
Introduction: High prevalence of obstructive lung disease has been reported in patients undergoing surgical correction of thoracic scoliosis. Airway narrowing due to spine morphology is analysed as a contributing factor. Methods: Preoperative surgical planning CTs of 34 patients with right-sided thoracic scoliosis (age: 17.6±9.0) were retrospectively analysed and compared with 15 non-scoliotic controls (age: 16.3±5.1). Three-dimensional models of spine and airway lumen were reconstructed...
2018: BMJ Open Respiratory Research
https://www.readbyqxmd.com/read/29531748/randomised-clinical-trial-of-an-early-palliative-care-intervention-support-for-patients-with-idiopathic-pulmonary-fibrosis-ipf-and-their-caregivers-protocol-and-key-design-considerations
#13
Kathleen Oare Lindell, Mehdi Nouraie, Melinda J Klesen, Sara Klein, Kevin F Gibson, Daniel J Kass, Margaret Quinn Rosenzweig
Introduction: Idiopathic pulmonary fibrosis (IPF), a progressive life-limiting lung disease affects approximately 128 000 newly diagnosed individuals in the USA annually. IPF, a disease of ageing associated with intense medical and financial burden, is expected to grow in incidence globally. Median survival from diagnosis is 3.8 years, and many of these patients succumb to a rapid death within 6 months. Despite the fatal prognosis, we have found that patients and caregivers often fail to understand the poor prognosis as the disease relentlessly progresses...
2018: BMJ Open Respiratory Research
https://www.readbyqxmd.com/read/29531747/patterns-and-management-of-chronic-obstructive-pulmonary-disease-in-urban-and-rural-china-a-community-based-survey-of-25-000-adults-across-10-regions
#14
Om P Kurmi, Kourtney J Davis, Kin Bong Hubert Lam, Yu Guo, Julien Vaucher, Derrick Bennett, Jenny Wang, Zheng Bian, Huaidong Du, Liming Li, Robert Clarke, Zhengming Chen
Introduction: Chronic obstructive pulmonary disease (COPD) is the third leading cause of death worldwide, with COPD deaths in China accounting for one-third of all such deaths. However, there is limited available evidence on the management of COPD in China. Methods: A random sample of 25 011 participants in the China Kadoorie Biobank, aged 38-87 years, from 10 regions in China was surveyed in 2013-2014. Data were collected using interviewer-administered questionnaires on the diagnosis ('doctor-diagnosed' or 'symptoms-based') and management of COPD (including use of medication and other healthcare resources), awareness of diagnosis and severity of symptoms in COPD cases...
2018: BMJ Open Respiratory Research
https://www.readbyqxmd.com/read/29531746/bts-guideline-for-the-investigation-and-management-of-malignant-pleural-mesothelioma
#15
Ian Woolhouse, Lesley Bishop, Liz Darlison, Duneesha de Fonseka, Anthony Edey, John Edwards, Corinne Faivre-Finn, Dean A Fennell, Steve Holmes, Keith M Kerr, Apostolos Nakas, Tim Peel, Najib M Rahman, Mark Slade, Jeremy Steele, Selina Tsim, Nick A Maskell
The full guideline for the investigation and management of malignant pleural mesothelioma is published in Thorax . The following is a summary of the recommendations and good practice points. The sections referred to in the summary refer to the full guideline.
2018: BMJ Open Respiratory Research
https://www.readbyqxmd.com/read/29531745/symptom-severity-and-its-effect-on-health-related-quality-of-life-over-time-in-patients-with-pulmonary-hypertension-a-multisite-longitudinal-cohort-study
#16
Janelle Yorke, Christi Deaton, Malcolm Campbell, Linda McGowen, Paul Sephton, David G Kiely, Iain Armstrong
Introduction: The aim of this cohort study was to examine health-related quality of life (HRQoL) and symptomatology in patients with pulmonary hypertension (PH) and explore factors that influence its evolution over time. Methods: A prospective longitudinal multisite cohort study. Participants were recruited from specialist UK PH centres and completed a questionnaire pack at baseline, 6, 12 and 18 months to assess HRQoL (emPHasis-10), dyspnoea, fatigue, sleep, anxiety and depression...
2018: BMJ Open Respiratory Research
https://www.readbyqxmd.com/read/29531744/is-childhood-wheeze-and-asthma-in-latin-america-associated-with-poor-hygiene-and-infection-a-systematic-review
#17
Cristina Ardura-Garcia, Paul Garner, Philip J Cooper
Introduction: High asthma prevalence in Latin-American cities is thought to be caused by poor hygiene and infections. This contradicts the widely accepted 'hygiene hypothesis' for asthma aetiology. Methods: Systematic review of observational studies evaluating the association between poor hygiene exposures or infections and asthma/wheeze among Latin-American children aged 4-16 years. MEDLINE, EMBASE, LILACS and CINAHL electronic databases were searched following a predefined strategy to 18 December 2017...
2018: BMJ Open Respiratory Research
https://www.readbyqxmd.com/read/29531743/using-domiciliary-non-invasive-ventilator-data-downloads-to-inform-clinical-decision-making-to-optimise-ventilation-delivery-and-patient-compliance
#18
Stephanie K Mansell, Steven Cutts, Isobel Hackney, Martin J Wood, Kevin Hawksworth, Dean D Creer, Cherry Kilbride, Swapna Mandal
Introduction: Ventilation parameter data from patients receiving home mechanical ventilation can be collected via secure data cards and modem technology. This can then be reviewed by clinicians and ventilator prescriptions adjusted. Typically available measures include tidal volume (VT ), leak, respiratory rate, minute ventilation, patient triggered breaths, achieved pressures and patient compliance. This study aimed to assess the potential impact of ventilator data downloads on management of patients requiring home non-invasive ventilation (NIV)...
2018: BMJ Open Respiratory Research
https://www.readbyqxmd.com/read/29468074/development-of-a-patient-centred-evidence-based-and-consensus-based-discharge-care-bundle-for-patients-with-acute-exacerbation-of-chronic-obstructive-pulmonary-disease
#19
Maria B Ospina, Marta Michas, Lesly Deuchar, Richard Leigh, Mohit Bhutani, Brian H Rowe, Darcy Marciniuk, Donna Goodridge, Gail Dechman, Jean Bourbeau, Meyer Balter, Pat Camp, Paul Hernandez, Roger S Goldstein, Michael K Stickland
Introduction: Hospital and emergency department discharge for patients with chronic obstructive pulmonary disease (COPD) is often poorly organised. We developed a patient-centred, evidence-based and consensus-based discharge care bundle for patients with acute exacerbations of COPD. Methods: A purposeful sample of clinicians and patients were invited to participate in a two-round Delphi study (July-November 2015). In round 1, participants rated on a seven-point Likert scale (1=not at all important; 7=extremely important) the importance of 29 unique COPD care actions...
2018: BMJ Open Respiratory Research
https://www.readbyqxmd.com/read/29468073/survival-prediction-in-mesothelioma-using-a-scalable-lasso-regression-model-instructions-for-use-and-initial-performance-using-clinical-predictors
#20
Andrew C Kidd, Michael McGettrick, Selina Tsim, Daniel L Halligan, Max Bylesjo, Kevin G Blyth
Introduction: Accurate prognostication is difficult in malignant pleural mesothelioma (MPM). We developed a set of robust computational models to quantify the prognostic value of routinely available clinical data, which form the basis of published MPM prognostic models. Methods: Data regarding 269 patients with MPM were allocated to balanced training (n=169) and validation sets (n=100). Prognostic signatures (minimal length best performing multivariate trained models) were generated by least absolute shrinkage and selection operator regression for overall survival (OS), OS <6 months and OS <12 months...
2018: BMJ Open Respiratory Research
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