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BMJ Open Respiratory Research

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https://www.readbyqxmd.com/read/29018528/correction-evaluation-of-the-current-landscape-of-respiratory-nurse-specialists-in-the-uk-planning-for-the-future-needs-of-patients
#1
(no author information available yet)
[This corrects the article DOI: 10.1136/bmjresp-2017-000210.][This corrects the article DOI: 10.1136/bmjresp-2017-000210.].
2017: BMJ Open Respiratory Research
https://www.readbyqxmd.com/read/29018527/british-thoracic-society-quality-standards-for-home-oxygen-use-in-adults
#2
Jay Suntharalingam, Tom Wilkinson, Joseph Annandale, Claire Davey, Rhea Fielding, Daryl Freeman, Michael Gibbons, Maxine Hardinge, Sabrine Hippolyte, Vikki Knowles, Cassandra Lee, William MacNee, Jacqueline Pollington, Vandana Vora, Trefor Watts, Meme Wijesinghe
INTRODUCTION: The purpose of the quality standards document is to provide healthcare professionals, commissioners, service providers and patients with a guide to standards of care that should be met for home oxygen provision in the UK, together with measurable markers of good practice. Quality statements are based on the British Thoracic Society (BTS) Guideline for Home Oxygen Use in Adults. METHODS: Development of BTS Quality Standards follows the BTS process of quality standard production based on the National Institute for Health and Care Excellence process manual for the development of quality standards...
2017: BMJ Open Respiratory Research
https://www.readbyqxmd.com/read/29018526/design-of-the-pf-ild-trial-a-double-blind-randomised-placebo-controlled-phase-iii-trial-of-nintedanib-in-patients-with-progressive-fibrosing-interstitial-lung-disease
#3
Kevin R Flaherty, Kevin K Brown, Athol U Wells, Emmanuelle Clerisme-Beaty, Harold R Collard, Vincent Cottin, Anand Devaraj, Yoshikazu Inoue, Florence Le Maulf, Luca Richeldi, Hendrik Schmidt, Simon Walsh, William Mezzanotte, Rozsa Schlenker-Herceg
600 patients aged ≥18 years will be randomised in a 1:1 ratio to nintedanib or placebo. Patients with diagnosis of IPF will be excluded. The study population will be enriched with two-thirds having a usual interstitial pneumonia-like pattern on HRCT. The primary endpoint is the annual rate of decline in forced vital capacity over 52 weeks. The main secondary endpoints are the absolute change from baseline in King's Brief Interstitial Lung Disease Questionnaire total score, time to first acute interstitial lung disease exacerbation or death and time to all-cause mortality over 52 weeks...
2017: BMJ Open Respiratory Research
https://www.readbyqxmd.com/read/29018525/concordance-of-opinions-between-patients-and-physicians-and-their-relationship-with-symptomatic-control-and-future-risk-in-patients-with-moderate-severe-asthma
#4
Astrid Crespo-Lessmann, Vicente Plaza, Francisco-Javier González-Barcala, Toni Fernández-Sánchez, Joaquín Sastre
INTRODUCTION: Differences between the opinions of patients and physicians on the impact of asthma are common. We hypothesised that patient-physician discordance may negatively affect asthma outcome. METHODS: A total of 2902 patients (61% women, mean age 47 years) with moderate-severe asthma and 231 physicians participated in a prospective study. At the baseline visit, data on demographics, clinical variables, degree of asthma control according to the Asthma Control Test (ACT), basic spirometry and the Hospital Anxiety and Depression Scale (HADS) were collected and an ad hoc questionnaire was completed that allowed the degree of concordance between doctors and patients to be assessed...
2017: BMJ Open Respiratory Research
https://www.readbyqxmd.com/read/28948026/design-of-the-subpopulations-and-intermediate-outcome-measures-in-copd-spiromics-air-study
#5
Nadia N Hansel, Laura M Paulin, Amanda J Gassett, Roger D Peng, Neil Alexis, Vincent S Fan, Eugene Bleecker, Russell Bowler, Alejandro P Comellas, Mark Dransfield, MeiLan K Han, Victor Kim, Jerry A Krishnan, Cheryl Pirozzi, Christopher B Cooper, Fernando Martinez, Prescott G Woodruff, Patrick J Breysse, R Graham Barr, Joel D Kaufman
INTRODUCTION: Population-based epidemiological evidence suggests that exposure to ambient air pollutants increases hospitalisations and mortality from chronic obstructive pulmonary disease (COPD), but less is known about the impact of exposure to air pollutants on patient-reported outcomes, morbidity and progression of COPD. METHODS AND ANALYSIS: The Subpopulations and Intermediate Outcome Measures in COPD (SPIROMICS) Air Pollution Study (SPIROMICS AIR) was initiated in 2013 to investigate the relation between individual-level estimates of short-term and long-term air pollution exposures, day-to-day symptom variability and disease progression in individuals with COPD...
2017: BMJ Open Respiratory Research
https://www.readbyqxmd.com/read/28912954/evaluation-of-the-current-landscape-of-respiratory-nurse-specialists-in-the-uk-planning-for-the-future-needs-of-patients
#6
Janelle Yorke, Sam Prigmore, Matt Hodson, Carol Stonham, Hannah Long, Sarah Bellhouse, Monica Fletcher, Sheila Edwards
INTRODUCTION: The National Health Service currently faces significant challenges and must optimise effective workforce planning and management. There are increasing concerns regarding poor workforce planning for respiratory medicine; a greater understanding of the role of respiratory nurse specialists will inform better workforce planning and management. METHODS: This was a survey study. Two surveys were administered: an organisational-level survey and an individual respiratory nurse survey...
2017: BMJ Open Respiratory Research
https://www.readbyqxmd.com/read/28883932/effect-of-vitamin-d3-on-the-antimicrobial-activity-of-human-airway-surface-liquid-preliminary-results-of-a-randomised-placebo-controlled-double-blind-trial
#7
Luis G Vargas Buonfiglio, Marlene Cano, Alejandro A Pezzulo, Oriana G Vanegas Calderon, Joseph Zabner, Alicia K Gerke, Alejandro P Comellas
INTRODUCTION: Vitamin D3 supplementation has been reported to prevent lung infections and increase the gene expression of antimicrobial peptides such as cathelicidin. We investigated the effect of vitamin D3 supplementation on the antimicrobial activity of airway surface liquid (ASL) in human subjects. Since smoking can increase the risk of respiratory infections, we also investigated the effect of smoking in the cathelicidin response to vitamin D3 in human airway epithelia in vitro. METHODS: This study is a subanalysis of single-centre community-based randomised placebo-controlled double-blind trial...
2017: BMJ Open Respiratory Research
https://www.readbyqxmd.com/read/28883931/rural-to-urban-migration-is-associated-with-increased-prevalence-of-childhood-wheeze-in-a-latin-american-city
#8
Alejandro Rodriguez, Maritza G Vaca, Martha E Chico, Laura C Rodrigues, Mauricio L Barreto, Philip J Cooper
INTRODUCTION: The urbanisation process has been associated with increases in asthma prevalence in urban and rural areas of low-income and middle-income countries (LMICs). However, although rural to urban migration and migration between cities are considered important determinants of this process, few studies have evaluated the effects of internal migration on asthma in urban populations of LMICs. The present study evaluated the effects of internal migration on the prevalence of wheeze in an urban area of Latin America...
2017: BMJ Open Respiratory Research
https://www.readbyqxmd.com/read/28883930/breathing-swallowing-discoordination-is-associated-with-frequent-exacerbations-of-copd
#9
Shinsuke Nagami, Yoshitaka Oku, Naomi Yagi, Susumu Sato, Ryuji Uozumi, Satoshi Morita, Yoshie Yamagata, Jun Kayashita, Kazuya Tanimura, Atsuyasu Sato, Ryosuke Takahashi, Shigeo Muro
INTRODUCTION: Impaired coordination between breathing and swallowing (breathing-swallowing discoordination) may be a significant risk factor for the exacerbation of chronic obstructive pulmonary disease (COPD). We examined breathing-swallowing discoordination in patients with COPD using a non-invasive and quantitative technique and determined its association with COPD exacerbation. METHODS: We recruited 65 stable outpatients with COPD who were enrolled in our prospective observational cohort study and did not manifest an apparent swallowing disorder...
2017: BMJ Open Respiratory Research
https://www.readbyqxmd.com/read/28883929/frailty-and-patient-reported-outcomes-in-subjects-with-chronic-obstructive-pulmonary-disease-are-they-independent-entities
#10
Masaaki Kusunose, Toru Oga, Saya Nakamura, Yoshinori Hasegawa, Koichi Nishimura
INTRODUCTION: There is a hypothesis that chronic obstructive pulmonary disease (COPD) is an accelerated ageing disease. Frailty is a geriatric syndrome characterised by physical, psychological and social vulnerability, thought to be a feature of ageing. The authors aimed to explore the relationship between frailty and physiological and patient-reported outcomes (PROs) in subjects with stable COPD. METHODS: We administered the Kihon Checklist that has been validated for frailty screening...
2017: BMJ Open Respiratory Research
https://www.readbyqxmd.com/read/28883928/cpap-impact-a-protocol-for-a-randomised-trial-of-bubble-continuous-positive-airway-pressure-versus-standard-care-for-high-risk-children-with-severe-pneumonia-using-adaptive-design-methods
#11
Andrew G Smith, Michelle Eckerle, Tisungane Mvalo, Brian Weir, Francis Martinson, Alfred Chalira, Norman Lufesi, Innocent Mofolo, Mina Hosseinipour, Eric D McCollum
INTRODUCTION: Pneumonia is a leading cause of mortality among children in low-resource settings. Mortality is greatest among children with high-risk conditions including HIV infection or exposure, severe malnutrition and/or severe hypoxaemia. WHO treatment recommendations include low-flow oxygen for children with severe pneumonia. Bubble continuous positive airway pressure (bCPAP) is a non-invasive support modality that provides positive end-expiratory pressure and oxygen. bCPAP is effective in the treatment of neonates in low-resource settings; its efficacy is unknown for high-risk children with severe pneumonia in low-resource settings...
2017: BMJ Open Respiratory Research
https://www.readbyqxmd.com/read/28883927/listening-panel-agreement-and-characteristics-of-lung-sounds-digitally-recorded-from-children-aged-1-59-months-enrolled-in-the-pneumonia-etiology-research-for-child-health-perch-case-control-study
#12
Eric D McCollum, Daniel E Park, Nora L Watson, W Chris Buck, Charatdao Bunthi, Akash Devendra, Bernard E Ebruke, Mounya Elhilali, Dimitra Emmanouilidou, Anthony J Garcia-Prats, Leah Githinji, Lokman Hossain, Shabir A Madhi, David P Moore, Justin Mulindwa, Dan Olson, Juliet O Awori, Warunee P Vandepitte, Charl Verwey, James E West, Maria D Knoll, Katherine L O'Brien, Daniel R Feikin, Laura L Hammit
INTRODUCTION: Paediatric lung sound recordings can be systematically assessed, but methodological feasibility and validity is unknown, especially from developing countries. We examined the performance of acoustically interpreting recorded paediatric lung sounds and compared sound characteristics between cases and controls. METHODS: Pneumonia Etiology Research for Child Health staff in six African and Asian sites recorded lung sounds with a digital stethoscope in cases and controls...
2017: BMJ Open Respiratory Research
https://www.readbyqxmd.com/read/28883926/clinical-use-of-nintedanib-in-patients-with-idiopathic-pulmonary-fibrosis
#13
REVIEW
Amy Hajari Case, Peace Johnson
Idiopathic pulmonary fibrosis (IPF) is a rare lung disease characterised by progressive loss of lung function, dyspnoea and cough. IPF has a variable clinical course but a poor prognosis. Nintedanib, a tyrosine kinase inhibitor, is one of two drugs approved for the treatment of IPF. In clinical trials, nintedanib slowed disease progression by reducing the rate of decline in forced vital capacity (FVC) in patients with IPF and mild or moderate lung function impairment. The effect of nintedanib was consistent across patient subgroups defined by baseline characteristics including FVC % predicted, diffusion capacity of the lung for carbon monoxide % predicted and the presence of emphysema...
2017: BMJ Open Respiratory Research
https://www.readbyqxmd.com/read/28883925/combining-creative-writing-and-narrative-analysis-to-deliver-new-insights-into-the-impact-of-pulmonary-hypertension
#14
Julia C Goddard, Iain J Armstrong, David G Kiely, Charlie A Elliot, Athanasios Charalampopoulos, Robin Condliffe, Brendan J Stone, Ian Sabroe
INTRODUCTION: Pulmonary hypertension is life limiting. Delays in diagnosis are common, and even after treatment has been initiated, pulmonary hypertension has marked effects on many aspects of social and physical function. We believed that a new approach to examining disease impact could be achieved through a combination of narrative research and creative writing. METHODS: Detailed unstructured narrative interviews with people with pulmonary hypertension were analysed thematically...
2017: BMJ Open Respiratory Research
https://www.readbyqxmd.com/read/28883924/metabolic-heterogeneity-of-idiopathic-pulmonary-fibrosis-a-metabolomic-study
#15
Yidan D Zhao, Li Yin, Stephen Archer, Catherine Lu, George Zhao, Yan Yao, Licun Wu, Michael Hsin, Thomas K Waddell, Shaf Keshavjee, John Granton, Marc de Perrot
INTRODUCTION: Idiopathic pulmonary fibrosis (IPF) is a chronic and fatal disease of unknown cause characterised by progressive fibrotic formation in lung tissue. We hypothesise that disrupted metabolic pathways in IPF contribute to disease pathogenesis. METHODS: Metabolomics of human IPF was performed using mass spectroscopy (IPF lung=8; donor lung=8). Gene expression of key metabolic enzymes was measured using microarrays. Of the 108 metabolites whose levels were found altered, 48 were significantly increased, whereas 60 were significantly decreased in IPF samples compared with normal controls...
2017: BMJ Open Respiratory Research
https://www.readbyqxmd.com/read/28883923/integrated-care-for-resected-early-stage-lung-cancer-innovations-and-exploring-patient-needs
#16
REVIEW
Jan Ho, Annette McWilliams, Jon Emery, Christobel Saunders, Christopher Reid, Suzanne Robinson, Fraser Brims
There is no consensus as to the duration and nature of follow-up following surgical resection with curative intent of lung cancer. The integration of cancer follow-up into primary care is likely to be a key future area for quality and cost-effective cancer care. Evidence from other solid cancer types demonstrates that such follow-up has no adverse outcomes, similar health-related quality of life, high patient satisfaction rates at a lower cost to the healthcare system. Core elements for successful models of shared cancer care are required: clear roles and responsibilities, timely effective communication, guidance on follow-up protocols and common treatments and rapid routes to (re)access specialist care...
2017: BMJ Open Respiratory Research
https://www.readbyqxmd.com/read/28883922/assessment-of-patient-reported-outcome-measures-in-pleural-interventions
#17
Ioannis Psallidas, Ahmed Yousuf, Ambika Talwar, Rob J Hallifax, Eleanor K Mishra, John P Corcoran, Nabeel Ali, Najib M Rahman
INTRODUCTION: There is a lack of data evaluating the clinical effect on symptoms of pleural intervention procedures. This has led to the development of patient-reported outcome measures (PROMs) to define what constitutes patient benefit. The primary aim of this paper was to prospectively assess the effect of pleural procedures on PROMs and investigate the relationship between symptom change and clinical factors. METHODS: We prospectively collected data as part of routine clinical care from 158 patients with pleural effusion requiring interventions...
2017: BMJ Open Respiratory Research
https://www.readbyqxmd.com/read/28883921/british-thoracic-society-guideline-for-oxygen-use-in-adults-in-healthcare-and-emergency-settings
#18
B R O'Driscoll, L S Howard, J Earis, V Mak
No abstract text is available yet for this article.
2017: BMJ Open Respiratory Research
https://www.readbyqxmd.com/read/28725446/sound-a-non-invasive-measure-of-cough-intensity
#19
Kai K Lee, Sergio Matos, Katie Ward, Gerrard F Rafferty, John Moxham, David H Evans, Surinder S Birring
INTRODUCTION: Cough intensity is an important determinant of cough severity reported by patients. Cough sound analysis has been widely validated for the measurement of cough frequency but few studies have validated its use in the assessment of cough strength. We investigated the relationship between cough sound and physiological measures of cough strength. METHODS: 32 patients with chronic cough and controls underwent contemporaneous measurements of voluntary cough sound, flow and oesophageal pressure...
2017: BMJ Open Respiratory Research
https://www.readbyqxmd.com/read/28725445/manual-ventilation-and-open-suction-procedures-contribute-to-negative-pressures-in-a-mechanical-lung-model
#20
Espen Rostrup Nakstad, Helge Opdahl, Fridtjof Heyerdahl, Fredrik Borchsenius, Ole Henning Skjønsberg
INTRODUCTION: Removal of pulmonary secretions in mechanically ventilated patients usually requires suction with closed catheter systems or flexible bronchoscopes. Manual ventilation is occasionally performed during such procedures if clinicians suspect inadequate ventilation. Suctioning can also be performed with the ventilator entirely disconnected from the endotracheal tube (ETT). The aim of this study was to investigate if these two procedures generate negative airway pressures, which may contribute to atelectasis...
2017: BMJ Open Respiratory Research
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