journal
MENU ▼
Read by QxMD icon Read
search

Antibiotics

journal
https://www.readbyqxmd.com/read/29165345/activity-in-vitro-of-clotrimazole-against-canine-methicillin-resistant-and-susceptible-staphylococcus-pseudintermedius
#1
Sian-Marie Frosini, Ross Bond
Emergence of multidrug-resistance in Staphylococcus pseudintermedius (SP) has increased interest in topical therapy as an alternative to systemic antibiotics in canine pyoderma. The antifungal imidazole, clotrimazole, is contained in numerous licensed canine ear preparations. Its in vitro activity against SP has not been evaluated, although previous studies have shown that the related imidazole, miconazole, has significant anti-staphylococcal efficacy. We therefore determined minimum inhibitory concentrations (MICs) of clotrimazole amongst 50 SP isolates (25 methicillin-resistant [MR]SP and susceptible [MS]SP) collected from dogs in Germany during 2010-2011 using an agar dilution method (CLSI VET01-A4)...
November 22, 2017: Antibiotics
https://www.readbyqxmd.com/read/29160808/interplay-between-colistin-resistance-virulence-and-fitness-in-acinetobacter-baumannii
#2
REVIEW
Gabriela Jorge Da Silva, Sara Domingues
Acinetobacter baumannii is an important opportunistic nosocomial pathogen often resistant to multiple antibiotics classes. Colistin, an "old" antibiotic, is now considered a last-line treatment option for extremely resistant isolates. In the meantime, resistance to colistin has been reported in clinical A. baumannii strains. Colistin is a cationic peptide that disrupts the outer membrane (OM) of Gram-negative bacteria. Colistin resistance is primarily due to post-translational modification or loss of the lipopolysaccharide (LPS) molecules inserted into the outer leaflet of the OM...
November 21, 2017: Antibiotics
https://www.readbyqxmd.com/read/29117107/bacteriophages-in-the-dairy-environment-from-enemies-to-allies
#3
REVIEW
Lucía Fernández, Susana Escobedo, Diana Gutiérrez, Silvia Portilla, Beatriz Martínez, Pilar García, Ana Rodríguez
The history of dairy farming goes back thousands of years, evolving from a traditional small-scale production to the industrialized manufacturing of fermented dairy products. Commercialization of milk and its derived products has been very important not only as a source of nourishment but also as an economic resource. However, the dairy industry has encountered several problems that have to be overcome to ensure the quality and safety of the final products, as well as to avoid economic losses. Within this context, it is interesting to highlight the role played by bacteriophages, or phages, viruses that infect bacteria...
November 8, 2017: Antibiotics
https://www.readbyqxmd.com/read/29112154/ubiquitous-nature-of-fluoroquinolones-the-oscillation-between-antibacterial-and-anticancer-activities
#4
REVIEW
Temilolu Idowu, Frank Schweizer
Fluoroquinolones are synthetic antibacterial agents that stabilize the ternary complex of prokaryotic topoisomerase II enzymes (gyrase and Topo IV), leading to extensive DNA fragmentation and bacteria death. Despite the similar structural folds within the critical regions of prokaryotic and eukaryotic topoisomerases, clinically relevant fluoroquinolones display a remarkable selectivity for prokaryotic topoisomerase II, with excellent safety records in humans. Typical agents that target human topoisomerases (such as etoposide, doxorubicin and mitoxantrone) are associated with significant toxicities and secondary malignancies, whereas clinically relevant fluoroquinolones are not known to exhibit such propensities...
November 7, 2017: Antibiotics
https://www.readbyqxmd.com/read/29112122/identification-and-antimicrobial-susceptibility-testing-of-anaerobic-bacteria-rubik-s-cube-of-clinical-microbiology
#5
REVIEW
Márió Gajdács, Gabriella Spengler, Edit Urbán
Anaerobic bacteria have pivotal roles in the microbiota of humans and they are significant infectious agents involved in many pathological processes, both in immunocompetent and immunocompromised individuals. Their isolation, cultivation and correct identification differs significantly from the workup of aerobic species, although the use of new technologies (e.g., matrix-assisted laser desorption/ionization time-of-flight mass spectrometry, whole genome sequencing) changed anaerobic diagnostics dramatically...
November 7, 2017: Antibiotics
https://www.readbyqxmd.com/read/29088074/exploring-patient-awareness-and-perceptions-of-the-appropriate-use-of-antibiotics-a-mixed-methods-study
#6
Marion E Davis, Tsai-Ling Liu, Yhenneko J Taylor, Lisa Davidson, Monica Schmid, Traci Yates, Janice Scotton, Melanie D Spencer
In the outpatient setting, estimates suggest that 30% of the antibiotics prescribed are unnecessary. This study explores patient knowledge and awareness of appropriate use of antibiotics and expectations regarding how antibiotics are used for their treatment in outpatient settings. A survey was administered to a convenience sample of patients, parents, and caregivers (n = 190) at seven primary care clinics and two urgent care locations. Fisher's exact tests compared results by patient characteristics. Although 89% of patients correctly believed that antibiotics work well for treating infections from bacteria, 53% incorrectly believed that antibiotics work well for treating viral infections...
October 31, 2017: Antibiotics
https://www.readbyqxmd.com/read/29088073/fosfomycin-pharmacological-clinical-and-future-perspectives
#7
REVIEW
Anneke Corinne Dijkmans, Natalia Veneranda Ortiz Zacarías, Jacobus Burggraaf, Johan Willem Mouton, Erik Bert Wilms, Cees van Nieuwkoop, Daniel Johannes Touw, Jasper Stevens, Ingrid Maria Catharina Kamerling
Fosfomycin is a bactericidal, low-molecular weight, broad-spectrum antibiotic, with putative activity against several bacteria, including multidrug-resistant Gram-negative bacteria, by irreversibly inhibiting an early stage in cell wall synthesis. Evidence suggests that fosfomycin has a synergistic effect when used in combination with other antimicrobial agents that act via a different mechanism of action, thereby allowing for reduced dosages and lower toxicity. Fosfomycin does not bind to plasma proteins and is cleared via the kidneys...
October 31, 2017: Antibiotics
https://www.readbyqxmd.com/read/29077003/antibiotic-prescribing-for-uncomplicated-acute-bronchitis-is-highest-in-younger-adults
#8
Larissa Grigoryan, Roger Zoorob, Jesal Shah, Haijun Wang, Monisha Arya, Barbara W Trautner
Reducing inappropriate antibiotic prescribing is currently a global health priority. Current guidelines recommend against antibiotic treatment for acute uncomplicated bronchitis. We studied antibiotic prescribing patterns for uncomplicated acute bronchitis and identified predictors of inappropriate antibiotic prescribing. We used the Epic Clarity database (electronic medical record system) to identify all adult patients with acute bronchitis in family medicine clinics from 2011 to 2016. We excluded factors that could justify antibiotic use, such as suspected pneumonia, COPD or immunocompromising conditions...
October 27, 2017: Antibiotics
https://www.readbyqxmd.com/read/29023420/probiotics-for-the-prevention-of-antibiotic-associated-diarrhea-in-outpatients-a-systematic-review-and-meta-analysis
#9
REVIEW
Sara Blaabjerg, Daniel Maribo Artzi, Rune Aabenhus
A common adverse effect of antibiotic use is diarrhea. Probiotics are living microorganisms, which, upon oral ingestion, may prevent antibiotic-associated diarrhea (AAD) by the normalization of an unbalanced gastrointestinal flora. The objective of this systematic review was to assess the benefits and harms of probiotics used for the prevention of AAD in an outpatient setting. A search of the PubMed database was conducted and yielded a total of 17 RCTs with 3631 participants to be included in the review. A meta-analysis was conducted for the primary outcome: the incidence of AAD...
October 12, 2017: Antibiotics
https://www.readbyqxmd.com/read/28946671/choline-kinase-a-novel-drug-target-for-the-inhibition-of-streptococcus-pneumoniae
#10
Tahl Zimmerman, Salam Ibrahim
Gram-positive pathogens, such as Streptococcuspneumoniae, can have deleterious effects on both human and animal health. Antibiotics and antimicrobials have been developed to treat infections caused by such pathogens and to prevent food contamination. However, these strategies have been increasingly thwarted by the emergence of resistant bacteria strains. Thus, new methods for controlling Gram-positive pathogen growth need to be continuously developed. Choline analogs, such as Hemicholinium-3 (HC-3), have been shown to be useful in blocking cell division in eukaryotic cells through the inhibition of choline kinase, an enzyme which catalyzes the production of phosphocholine from choline and ATP...
September 25, 2017: Antibiotics
https://www.readbyqxmd.com/read/28902135/point-prevalence-surveys-of-antimicrobial-use-among-hospitalized-children-in-six-hospitals-in-india-in-2016
#11
Sumanth Gandra, Sanjeev K Singh, Dasaratha R Jinka, Ravishankar Kanithi, Ashok K Chikkappa, Anita Sharma, Dhanya Dharmapalan, Anil Kumar Vasudevan, Onkaraiah Tunga, Akhila Akula, Garima Garg, Yingfen Hsia, Srinivas Murki, Gerardo Alvarez-Uria, Mike Sharland, Ramanan Laxminarayan
The prevalence of antimicrobial resistance in India is among the highest in the world. Antimicrobial use in inpatient settings is an important driver of resistance, but is poorly characterized, particularly in hospitalized children. In this study, conducted as part of the Global Antimicrobial Resistance, Prescribing, and Efficacy in Neonates and Children (GARPEC) project, we examined the prevalence of and indications of antimicrobial use, as well as antimicrobial agents used among hospitalized children by conducting four point prevalence surveys in six hospitals between February 2016 and February 2017...
September 13, 2017: Antibiotics
https://www.readbyqxmd.com/read/28892020/identification-of-staphylococcus-aureus-cellular-pathways-affected-by-the-stilbenoid-lead-drug-sk-03-92-using-a-microarray
#12
William R Schwan, Rebecca Polanowski, Paul M Dunman, Sara Medina-Bielski, Michelle Lane, Marc Rott, Lauren Lipker, Amy Wescott, Aaron Monte, James M Cook, Douglas D Baumann, V V N Phani Babu Tiruveedhula, Christopher M Witzigmann, Cassandra Mikel, Md Toufiqur Rahman
The mechanism of action for a new lead stilbene compound coded SK-03-92 with bactericidal activity against methicillin-resistant Staphylococcus aureus (MRSA) is unknown. To gain insight into the killing process, transcriptional profiling was performed on SK-03-92 treated vs. untreated S. aureus. Fourteen genes were upregulated and 38 genes downregulated by SK-03-92 treatment. Genes involved in sortase A production, protein metabolism, and transcriptional regulation were upregulated, whereas genes encoding transporters, purine synthesis proteins, and a putative two-component system (SACOL2360 (MW2284) and SACOL2361 (MW2285)) were downregulated by SK-03-92 treatment...
September 11, 2017: Antibiotics
https://www.readbyqxmd.com/read/28892001/synthesis-and-immunological-evaluation-of-virus-like-particle-milbemycin-a%C3%A2-a%C3%A2-conjugates
#13
Andris Zeltins, Māris Turks, Dace Skrastina, Jevgeņija Lugiņina, Ieva Kalnciema, Ina Balke, Ērika Bizdēna, Vitalijs Skrivelis
Milbemycins are macrolide antibiotics with a broad spectrum of nematocidal, insecticidal, and acaricidal activity. To obtain milbemycin A₃/A₄ derivatives suitable for chemical conjugation to protein carriers (milbemycin haptens), succinate linker and a novel 17-atom-long linker containing a terminal carboxylic acid group were attached to the milbemycin core in a protecting group-free synthesis. The obtained milbemycin A₃/A₄ derivatives were coupled to Potato virus Y-like nanoparticles by the activated ester method...
September 11, 2017: Antibiotics
https://www.readbyqxmd.com/read/28813003/self-assessment-of-antimicrobial-stewardship-in-primary-care-self-reported-practice-using-the-target-primary-care-self-assessment-tool
#14
Rebecca Owens, Leah Ffion Jones, Michael Moore, Dirk Pilat, Cliodna McNulty
Multifaceted antimicrobial stewardship (AMS) interventions including: antibiotic guidance, reviews of antibiotic use using audits, education, patient facing materials, and self-assessment, are successful in improving antimicrobial use. We aimed to measure the self-reported AMS activity of staff completing a self-assessment tool (SAT). The Royal College of General Practitioners (RCGP)/Public Health England (PHE) SAT enables participants considering an AMS eLearning course to answer 12 short questions about their AMS activities...
August 16, 2017: Antibiotics
https://www.readbyqxmd.com/read/28767074/comparative-study-on-antistaphylococcal-activity-of-lipopeptides-in-various-culture-media
#15
Maciej Jaśkiewicz, Damian Neubauer, Wojciech Kamysz
Staphylococcus aureus bacteria are one of the leading microorganisms responsible for nosocomial infections as well as being the primary causative pathogen of skin and wound infections. Currently, the therapy of staphylococcal diseases faces many difficulties, due to a variety of mechanisms of resistance and virulence factors. Moreover, a number of infections caused by S. aureus are connected with biofilm formation that impairs effectiveness of the therapy. Short cationic lipopeptides that are designed on the basis of the structure of antimicrobial peptides are likely to provide a promising alternative to conventional antibiotics...
August 2, 2017: Antibiotics
https://www.readbyqxmd.com/read/28677631/macromolecular-conjugate-and-biological-carrier-approaches-for-the-targeted-delivery-of-antibiotics
#16
REVIEW
Nhan Dai Thien Tram, Pui Lai Rachel Ee
For the past few decades, the rapid rise of antibiotic multidrug-resistance has presented a palpable threat to human health worldwide. Meanwhile, the number of novel antibiotics released to the market has been steadily declining. Therefore, it is imperative that we utilize innovative approaches for the development of antimicrobial therapies. This article will explore alternative strategies, namely drug conjugates and biological carriers for the targeted delivery of antibiotics, which are often eclipsed by their nanomedicine-based counterparts...
July 4, 2017: Antibiotics
https://www.readbyqxmd.com/read/28657596/antibacterial-activity-and-toxicity-of-analogs-of-scorpion-venom-isct-peptides
#17
Roberto de la Salud Bea, Adam F Petraglia, Michael R Ascuitto, Quentin M Buck
Seven analogs of the natural, α-helix peptides IsCT1 and IsCT2-found in the venom of scorpion Opithancatus Madagascariensis-have been synthesized and tested to compare their antibacterial and hemolytic activity against natural peptides. In general, results show that increasing hydrophobicity by substituting positions 5 and 9 of the sequences with alanine, valine, and leucine, enhances antibacterial activity. However, this also increases hemolytic activity. The analog with an increased net positive charge from +1 to +3 produces moderate bacterial growth inhibition but also has high hemolytic activity...
June 28, 2017: Antibiotics
https://www.readbyqxmd.com/read/28587316/bacteria-from-animals-as-a-pool-of-antimicrobial-resistance-genes
#18
REVIEW
Maria Angeles Argudín, Ariane Deplano, Alaeddine Meghraoui, Magali Dodémont, Amelie Heinrichs, Olivier Denis, Claire Nonhoff, Sandrine Roisin
Antimicrobial agents are used in both veterinary and human medicine. The intensive use of antimicrobials in animals may promote the fixation of antimicrobial resistance genes in bacteria, which may be zoonotic or capable to transfer these genes to human-adapted pathogens or to human gut microbiota via direct contact, food or the environment. This review summarizes the current knowledge of the use of antimicrobial agents in animal health and explores the role of bacteria from animals as a pool of antimicrobial resistance genes for human bacteria...
June 6, 2017: Antibiotics
https://www.readbyqxmd.com/read/28441360/erythromycin-modification-that-improves-its-acidic-stability-while-optimizing-it-for-local-drug-delivery
#19
Erika L Cyphert, Jaqueline D Wallat, Jonathan K Pokorski, Horst A von Recum
The antibiotic erythromycin has limited efficacy and bioavailability due to its instability and conversion under acidic conditions via an intramolecular dehydration reaction. To improve the stability of erythromycin, several analogs have been developed-such as azithromycin and clarithromycin-which decrease the rate of intramolecular dehydration. We set out to build upon this prior work by developing a conjugate of erythromycin with improved pH stability, bioavailability, and preferential release from a drug delivery system directly at the low pH of an infection site...
April 25, 2017: Antibiotics
https://www.readbyqxmd.com/read/28327498/activity-of-sulfa-drugs-and-their-combinations-against-stationary-phase-b-burgdorferi-in-vitro
#20
Jie Feng, Shuo Zhang, Wanliang Shi, Ying Zhang
Lyme disease is a most common vector-borne disease in the US. Although the majority of Lyme patients can be cured with the standard two- to four-week antibiotic treatment, at least 10%-20% of patients continue to suffer from prolonged post-treatment Lyme disease syndrome (PTLDS). While the cause for this is unclear, one possibility is that persisting organisms are not killed by current Lyme antibiotics. In our previous studies, we screened an FDA drug library and an NCI compound library on B. burgdorferi and found some drug hits including sulfa drugs as having good activity against B...
March 22, 2017: Antibiotics
journal
journal
49490
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"