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Neurology® Neuroimmunology & Neuroinflammation

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https://www.readbyqxmd.com/read/29318181/neuroimmunology-of-oms-and-anna-1-anti-hu-paraneoplastic-syndromes-in-a-child-with-neuroblastoma
#1
Michael R Pranzatelli, Nathan R McGee
No abstract text is available yet for this article.
March 2018: Neurology® Neuroimmunology & Neuroinflammation
https://www.readbyqxmd.com/read/29318180/systemic-inflammatory-response-syndrome-infection-and-outcome-in-intracerebral-hemorrhage
#2
Amelia K Boehme, Mary E Comeau, Carl D Langefeld, Aaron Lord, Charles J Moomaw, Jennifer Osborne, Michael L James, Sharyl Martini, Fernando D Testai, Daniel Woo, Mitchell S V Elkind
Objective: Systemic inflammatory response syndrome (SIRS) may be related to poor outcomes after intracerebral hemorrhage (ICH). Methods: The Ethnic/Racial Variations of Intracerebral Hemorrhage study is an observational study of ICH in whites, blacks, and Hispanics throughout the United Sates. SIRS was defined by standard criteria as 2 or more of the following on admission: (1) body temperature <36°C or >38°C, (2) heart rate >90 beats per minute, (3) respiratory rate >20 breaths per minute, or (4) white blood cell count <4,000/mm3 or >12,000/mm3...
March 2018: Neurology® Neuroimmunology & Neuroinflammation
https://www.readbyqxmd.com/read/29296636/characterization-of-lymphopenia-in-patients-with-ms-treated-with-dimethyl-fumarate-and-fingolimod
#3
Maryam Nakhaei-Nejad, David Barilla, Chieh-Hsin Lee, Gregg Blevins, Fabrizio Giuliani
Objective: Lymphopenia is a common occurrence of disease-modifying therapies (DMTs) for relapsing-remitting MS (RRMS). The aim of this study was to dissect the prevalence of various lymphocyte subsets in patients with RRMS treated with 2 DMTs commonly associated with lymphopenia, dimethyl fumarate (DMF), and fingolimod (FTY). Methods: Multicolor flow cytometry and multiplex assays were used to identify up to 50 lymphocyte subpopulations and to examine the expression of multiple cytokines in selected patients...
March 2018: Neurology® Neuroimmunology & Neuroinflammation
https://www.readbyqxmd.com/read/29296635/proinflammatory-b-cell-profile-in-the-early-phases-of-ms-predicts-an-active-disease
#4
Thomas Guerrier, Myriam Labalette, David Launay, Catalina Lee-Chang, Olivier Outteryck, Guillaume Lefèvre, Patrick Vermersch, Sylvain Dubucquoi, Hélène Zéphir
Objective: To assess whether any alteration of B-cell subset distribution and/or the cytokine production capacities of B cells could be associated with any stage of MS and could be predictive of MS evolution. Methods: We prospectively enrolled radiologically isolated syndrome (RIS), clinically isolated syndrome (CIS), naive patients with relapsing remitting MS (RRMS) of any disease modifying drug, and healthy controls (HCs). Peripheral blood B-cell subset distributions and the interleukin (IL)-6/IL-10-producing B-cell ratio were assessed by flow cytometry to evaluate their proinflammatory and anti-inflammatory functional properties...
March 2018: Neurology® Neuroimmunology & Neuroinflammation
https://www.readbyqxmd.com/read/29296634/anterior-interosseous-mononeuropathy-associated-with-hev-infection
#5
Bart Swinnen, Steven Boeynaems, Maarten Schrooten, Veroniek Saegeman, Kristl G Claeys, Philip Van Damme
No abstract text is available yet for this article.
March 2018: Neurology® Neuroimmunology & Neuroinflammation
https://www.readbyqxmd.com/read/29312999/covertly-active-and-progressing-neurochemical-abnormalities-in-suppressed-hiv-infection
#6
Lucette A Cysique, Lauriane Jugé, Thomas Gates, Michael Tobia, Kirsten Moffat, Bruce J Brew, Caroline Rae
Objective: To assess whether HIV-related brain injury is progressive in persons with suppressed HIV infection. Methods: Seventy-three HIV+ virally suppressed men and 35 HIV- men, screened for psychiatric and alcohol/drug use disorders, underwent neuropsychological evaluation and proton magnetic resonance spectroscopy (1H-MRS) at baseline and after and 23 ± 5 months. 1H-MRS included brain regions known to be vulnerable to HIV and aging: frontal white matter (FWM), posterior cingulate cortex (PCC), and caudate area (CA)...
January 2018: Neurology® Neuroimmunology & Neuroinflammation
https://www.readbyqxmd.com/read/29312998/message-from-the-editor-to-our-reviewers
#7
EDITORIAL
Josep Dalmau
No abstract text is available yet for this article.
January 2018: Neurology® Neuroimmunology & Neuroinflammation
https://www.readbyqxmd.com/read/29296633/pleocytosis-is-not-fully-responsible-for-low-csf-glucose-in-meningitis
#8
Maxime O Baud, Jeffrey R Vitt, Nathaniel M Robbins, Rafael Wabl, Michael R Wilson, Felicia C Chow, Jeffrey M Gelfand, S Andrew Josephson, Steve Miller
Objective: The mechanism of hypoglycorrhachia-low CSF glucose-in meningitis remains unknown. We sought to evaluate the relative contribution of CSF inflammation vs microorganisms (bacteria and fungi) in lowering CSF glucose levels. Methods: We retrospectively categorized CSF profiles into microbial and aseptic meningitis and analyzed CSF leukocyte count, glucose, and protein concentrations. We assessed the relationship between these markers using multivariate and stratified linear regression analysis for initial and repeated CSF sampling...
January 2018: Neurology® Neuroimmunology & Neuroinflammation
https://www.readbyqxmd.com/read/29259999/progressive-inner-nuclear-layer-dysfunction-in-non-optic-neuritis-eyes-in-ms
#9
Yuyi You, Elizabeth C Graham, Ting Shen, Con Yiannikas, John Parratt, Vivek Gupta, Joshua Barton, Michael Dwyer, Michael H Barnett, Clare L Fraser, Stuart L Graham, Alexander Klistorner
Objective: To investigate primary retinal functional changes in non-optic neuritis (ON) eyes of patients with MS by full-field electroretinography (ERG). Methods: Seventy-seven patients with relapsing-remitting MS with no history of clinical ON in at least 1 eye and 30 healthy controls were recruited in the cohort study. Full-field ERGs were recorded, and retinal optical coherence tomography scans were performed to assess the thicknesses of peripapillary retinal nerve fiber layer (RNFL) and retinal ganglion cell layer-inner plexiform layer (GCL-IPL)...
January 2018: Neurology® Neuroimmunology & Neuroinflammation
https://www.readbyqxmd.com/read/29259998/safety-and-preliminary-efficacy-of-deep-transcranial-magnetic-stimulation-in-ms-related-fatigue
#10
Gunnar Gaede, Marina Tiede, Ina Lorenz, Alexander U Brandt, Caspar Pfueller, Jan Dörr, Judith Bellmann-Strobl, Sophie K Piper, Yiftach Roth, Abraham Zangen, Sven Schippling, Friedemann Paul
Objective: To conduct a randomized, sham-controlled phase I/IIa study to evaluate the safety and preliminary efficacy of deep brain H-coil repetitive transcranial magnetic stimulation (rTMS) over the prefrontal cortex (PFC) and the primary motor cortex (MC) in patients with MS with fatigue or depression (NCT01106365). Methods: Thirty-three patients with MS were recruited to undergo 18 consecutive rTMS sessions over 6 weeks, followed by follow-up (FU) assessments over 6 weeks...
January 2018: Neurology® Neuroimmunology & Neuroinflammation
https://www.readbyqxmd.com/read/29259997/evidence-of-b-cell-dysregulation-in-severe-cns-inflammation-after-alemtuzumab-therapy
#11
Francesca Rinaldi, Lisa Federle, Marco Puthenparampil, Paola Perini, Francesca Grassivaro, Paolo Gallo
No abstract text is available yet for this article.
January 2018: Neurology® Neuroimmunology & Neuroinflammation
https://www.readbyqxmd.com/read/29259996/phenotypic-and-functional-complexity-of-brain-infiltrating-t-cells-in-rasmussen-encephalitis
#12
Faiez Al Nimer, Ivan Jelcic, Christian Kempf, Tom Pieper, Herbert Budka, Mireia Sospedra, Roland Martin
Objective: To characterize the brain-infiltrating immune cell repertoire in Rasmussen encephalitis (RE) with special focus on the subsets, clonality, and their cytokine profile. Methods: The immune cell infiltrate of freshly isolated brain tissue from RE was phenotypically and functionally characterized using immunohistology, flow cytometry, and T-cell receptor (TCR) deep sequencing. Identification of clonally expanded T-cell clones (TCCs) was achieved by combining flow cytometry sorting of CD4+ and CD8+ T cells and high-throughput TCR Vβ-chain sequencing...
January 2018: Neurology® Neuroimmunology & Neuroinflammation
https://www.readbyqxmd.com/read/29259995/anti-lingo-1-has-no-detectable-immunomodulatory-effects-in-preclinical-and-phase-1-studies
#13
Ann Ranger, Soma Ray, Suzanne Szak, Andrea Dearth, Norm Allaire, Ronald Murray, Rebecca Gardner, Diego Cadavid, Sha Mi
Objective: To evaluate whether the anti-LINGO-1 antibody has immunomodulatory effects. Methods: Human peripheral blood mononuclear cells (hPBMCs), rat splenocytes, and rat CD4+ T cells were assessed to determine whether LINGO-1 was expressed and was inducible. Anti-LINGO-1 Li81 (0.1-30 μg/mL) effect on proliferation/cytokine production was assessed in purified rat CD4+ T cells and hPBMCs stimulated with antibodies to CD3 +/- CD28. In humans, the effect of 2 opicinumab (anti-LINGO-1/BIIB033; 30, 60, and 100 mg/kg) or placebo IV administrations was evaluated in RNA from blood and CSF samples taken before and after administration in phase 1 clinical trials; paired samples were assessed for differentially expressed genes by microarray...
January 2018: Neurology® Neuroimmunology & Neuroinflammation
https://www.readbyqxmd.com/read/29209636/neurofilament-light-chain-predicts-disease-activity-in-relapsing-remitting-ms
#14
Kristin N Varhaug, Christian Barro, Kjetil Bjørnevik, Kjell-Morten Myhr, Øivind Torkildsen, Stig Wergeland, Laurence A Bindoff, Jens Kuhle, Christian Vedeler
Objective: To investigate whether serum neurofilament light chain (NF-L) and chitinase 3-like 1 (CHI3L1) predict disease activity in relapsing-remitting MS (RRMS). Methods: A cohort of 85 patients with RRMS were followed for 2 years (6 months without disease-modifying treatment and 18 months with interferon-beta 1a [IFNB-1a]). Expanded Disability Status Scale was scored at baseline and every 6 months thereafter. MRI was performed at baseline and monthly for 9 months and then at months 12 and 24...
January 2018: Neurology® Neuroimmunology & Neuroinflammation
https://www.readbyqxmd.com/read/29209635/serum-neurofilament-light-chain-in-relapsing-remitting-ms-unchaining-disease-activity-prediction
#15
EDITORIAL
Ruth Ann Marrie
No abstract text is available yet for this article.
January 2018: Neurology® Neuroimmunology & Neuroinflammation
https://www.readbyqxmd.com/read/29159205/decreased-occipital-lobe-metabolism-by-fdg-pet-ct-an-anti-nmda-receptor-encephalitis-biomarker
#16
John C Probasco, Lilja Solnes, Abhinav Nalluri, Jesse Cohen, Krystyna M Jones, Elcin Zan, Mehrbod S Javadi, Arun Venkatesan
Objective: To compare brain metabolism patterns on fluorodeoxyglucose (FDG)-PET/CT in anti-NMDA receptor and other definite autoimmune encephalitis (AE) and to assess how these patterns differ between anti-NMDA receptor neurologic disability groups. Methods: Retrospective review of clinical data and initial dedicated brain FDG-PET/CT studies for neurology inpatients with definite AE, per published consensus criteria, treated at a single academic medical center over a 10-year period...
January 2018: Neurology® Neuroimmunology & Neuroinflammation
https://www.readbyqxmd.com/read/29159204/immune-response-to-vaccines-is-maintained-in-patients-treated-with-dimethyl-fumarate
#17
Christian von Hehn, Jonathan Howard, Shifang Liu, Ven Meka, Joe Pultz, Devangi Mehta, Claudia Prada, Soma Ray, Michael R Edwards, Sarah I Sheikh
Objectives: To investigate the immune response to vaccinations in patients with relapsing forms of MS treated with delayed-release dimethyl fumarate (DMF) vs nonpegylated interferon (IFN). Methods: In this open-label, multicenter study, patients received 3 vaccinations: (1) tetanus-diphtheria toxoid (Td) to test T-cell-dependent recall response, (2) pneumococcal vaccine polyvalent to test T-cell-independent humoral response, and (3) meningococcal (groups A, C, W-135, and Y) oligosaccharide CRM197 conjugate to test T-cell-dependent neoantigen response...
January 2018: Neurology® Neuroimmunology & Neuroinflammation
https://www.readbyqxmd.com/read/29114566/reversible-paraspinal-muscle-hyperintensity-in-anti-mog-antibody-associated-transverse-myelitis
#18
Lekha Pandit, Sharik Mustafa, Raghuraj Uppoor, Ichiro Nakashima, Toshiyuki Takahashi, Kimihiko Kaneko
No abstract text is available yet for this article.
January 2018: Neurology® Neuroimmunology & Neuroinflammation
https://www.readbyqxmd.com/read/29114565/brachio-cervical-inflammatory-myopathy-with-associated-scleroderma-phenotype-and-lupus-serology
#19
Andrew F Gao, Philip A Saleh, Charles D Kassardjian, Ophir Vinik, David G Munoz
No abstract text is available yet for this article.
January 2018: Neurology® Neuroimmunology & Neuroinflammation
https://www.readbyqxmd.com/read/29082298/radiologically-isolated-syndrome-in-children-can-we-predict-future-events
#20
EDITORIAL
E Ann Yeh
No abstract text is available yet for this article.
November 2017: Neurology® Neuroimmunology & Neuroinflammation
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