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Neurology® Neuroimmunology & Neuroinflammation

Josefine Radke, Randi Koll, Corinna Preuße, Debora Pehl, Kremena Todorova, Constanze Schönemann, Yves Allenbach, Eleonora Aronica, Marianne de Visser, Frank L Heppner, Joachim Weis, Soroush Doostkam, Thierry Maisonobe, Olivier Benveniste, Hans-Hilmar Goebel, Werner Stenzel
Objective: To study the B-cell content, organization, and existence of distinct B-cell subpopulations in relation to the expression of type 1 interferon signature related genes in dermatomyositis (DM). Methods: Evaluation of skeletal muscle biopsies from patients with adult DM (aDM) and juvenile DM (jDM) by histology, immunohistochemistry, electron microscopy, and quantitative reverse-transcription PCR. Results: We defined 3 aDM subgroups-classic (containing occasional B cells without clusters), B-cell-rich, and follicle-like aDM-further elucidating IM B-lymphocyte maturation and immunity...
May 2018: Neurology® Neuroimmunology & Neuroinflammation
Eero Rissanen, Jouni Tuisku, Tero Vahlberg, Marcus Sucksdorff, Teemu Paavilainen, Riitta Parkkola, Johanna Rokka, Alexander Gerhard, Rainer Hinz, Peter S Talbot, Juha O Rinne, Laura Airas
Objective: To investigate the relationship of in vivo microglial activation to clinical and MRI parameters in MS. Methods: Patients with secondary progressive MS (n = 10) or relapsing-remitting MS (n = 10) and age-matched healthy controls (n = 17) were studied. Microglial activation was measured using PET and radioligand [11 C]( R )-PK11195. Clinical assessment and structural and quantitative MRI including diffusion tensor imaging (DTI) were performed for comparison...
May 2018: Neurology® Neuroimmunology & Neuroinflammation
Carl Johan Molin, Liis Sabre, Cleo-Aron Weis, Tanel Punga, Anna Rostedt Punga
Objective: The aim of the study was to analyze the effect of thymectomy on the proposed disease-specific microRNA (miRNA) biomarkers miR-150-5p and miR-21-5p in patients from the prospective randomized trial of thymectomy in myasthenia gravis (MGTX trial) and to evaluate the longitudinal changes in clinical patterns compared with these miRNA levels. Methods: Serum samples were obtained from 80 patients with MG who were included in the MGTX trial. Thirty-eight patients were randomized to thymectomy plus prednisone treatment, and 42 patients were randomized to prednisone treatment...
May 2018: Neurology® Neuroimmunology & Neuroinflammation
Veronica P Cipriani, Nancy Arndt, Peter Pytel, Anthony T Reder, Adil Javed
No abstract text is available yet for this article.
May 2018: Neurology® Neuroimmunology & Neuroinflammation
Olga von Bismarck, Theresa Dankowski, Björn Ambrosius, Nicole Hessler, Gisela Antony, Andreas Ziegler, Muna-Miriam Hoshi, Lilian Aly, Felix Luessi, Sergiu Groppa, Luisa Klotz, Sven G Meuth, Björn Tackenberg, Muriel Stoppe, Florian Then Bergh, Hayrettin Tumani, Tania Kümpfel, Martin Stangel, Christoph Heesen, Brigitte Wildemann, Friedemann Paul, Antonios Bayas, Clemens Warnke, Frank Weber, Ralf A Linker, Ulf Ziemann, Uwe K Zettl, Frauke Zipp, Heinz Wiendl, Bernhard Hemmer, Ralf Gold, Anke Salmen
Objective: To assess clinical characteristics, distribution of disease-modifying treatments (DMTs), and neuropsychological symptoms in a large cohort of patients with early-stage MS. Methods: The German National MS Cohort is a multicenter prospective longitudinal cohort study that has recruited DMT-naive patients with clinically isolated syndrome (CIS) and relapsing-remitting MS (RRMS) since 2010. We evaluated their baseline characteristics and the prevalence of neuropsychological symptoms...
May 2018: Neurology® Neuroimmunology & Neuroinflammation
Yuri Mizuno, Koji Shinoda, Mitsuru Watanabe, Takuya Matsushita, Ryo Yamasaki, Jun-Ichi Kira
No abstract text is available yet for this article.
May 2018: Neurology® Neuroimmunology & Neuroinflammation
Shannon R Hinson, A Sebastian Lopez-Chiriboga, James H Bower, Joseph Y Matsumoto, Anhar Hassan, Eati Basal, Vanda A Lennon, Sean J Pittock, Andrew McKeon
Background: Glycine receptor alpha-1 subunit (GlyRα1)-immunoglobulin G (IgG) is diagnostic of stiff-person syndrome (SPS) spectrum but has been reported detectable in other neurologic diseases for which significance is less certain. Methods: To assess GlyRα1-IgGs as biomarkers of SPS spectrum among patients and controls, specimens were tested using cell-based assays (binding [4°C] and modulating [antigen endocytosing, 37°C]). Medical records of seropositive patients were reviewed...
March 2018: Neurology® Neuroimmunology & Neuroinflammation
Burcu Zeydan, Xinyi Gu, Elizabeth J Atkinson, B Mark Keegan, Brian G Weinshenker, Jan-Mendelt Tillema, Daniel Pelletier, Christina J Azevedo, Christine Lebrun-Frenay, Aksel Siva, Darin T Okuda, Kejal Kantarci, Orhun H Kantarci
Objective: To assess whether cervical spinal cord atrophy heralds the onset of progressive MS. Methods: We studied 34 individuals with radiologically isolated syndrome (RIS) and 31 patients with relapsing-remitting MS (RRMS) age matched to 25 patients within a year of onset of secondary progressive MS (SPMS). Two raters independently measured (twice per rater) the cervical spinal cord average segmental area (CASA) (mm2 ) of axial T2-weighted images between C2 and C7 landmarks...
March 2018: Neurology® Neuroimmunology & Neuroinflammation
(no author information available yet)
[This corrects the article on p. e427 in vol. 5, PMID: 29259999.].
March 2018: Neurology® Neuroimmunology & Neuroinflammation
(no author information available yet)
[This corrects the article on p. e432 in vol. 5, PMID: 29296636.].
March 2018: Neurology® Neuroimmunology & Neuroinflammation
Philipp Eisele, Kristina Szabo, Anne Ebert, Wolfgang Brueck, Michael Platten, Achim Gass
Objective: To investigate the spatiotemporal evolution of venous narrowing in newly developing MS lesions in a longitudinal MRI study including susceptibility-weighted images (SWIs). Methods: We retrospectively investigated serial MR examinations of 18 patients with MS acquired on a 3T MRI system including SWI for acute contrast-enhancing lesions with at least 1 MRI examination before contrast enhancement. The mean diameter of veins at the time point of contrast enhancement was compared with the mean diameter of veins before and after contrast enhancement...
March 2018: Neurology® Neuroimmunology & Neuroinflammation
Rehana Z Hussain, William A Miller-Little, Richard Doelger, Gary R Cutter, Nicolas Loof, Petra D Cravens, Olaf Stüve
Objective: To determine the capacity, effectiveness, efficiency, and reliability of select tissue dissociation methods to isolate mononuclear cells from the CNS of mice with experimental autoimmune encephalomyelitis (EAE). Methods: As part of an assay qualification, we tested the isolation method Percoll PLUS vs a commercially available enzymatic Neural Tissue Dissociation Kit (Kit), and the enzymes accutase and papain in C57BL/6 mice with active EAE. In a stepwise approach, we applied the following 4 criteria to each dissociation method: (1) mononuclear cell viability post-processing was required to be ≥80% per brain or spinal cord sample, (2) absolute live mononuclear cell numbers was required to be ≥5 × 105 per brain or spinal cord sample of mice with clinical EAE, (3) test-retest reliability had to be verified, and (4) the absolute mononuclear cell numbers in brain and spinal cord had to correlate with the EAE disease course...
March 2018: Neurology® Neuroimmunology & Neuroinflammation
Paula Alcaide-Leon, Kateryna Cybulsky, Stephanie Sankar, Courtney Casserly, General Leung, Marika Hohol, Daniel Selchen, Xavier Montalban, Aditya Bharatha, Jiwon Oh
Objectives: To assess whether quantitative spinal cord MRI (SC-MRI) measures, including atrophy, and diffusion tensor imaging (DTI) and magnetization transfer imaging metrics were different in radiologically isolated syndrome (RIS) vs healthy controls (HCs). Methods: Twenty-four participants with RIS and 14 HCs underwent cervical SC-MRI on a 3T magnet. Manually segmented regions of interest circumscribing the spinal cord cross-sectional area (SC-CSA) between C3 and C4 were used to extract SC-CSA, fractional anisotropy, mean, perpendicular, and parallel diffusivity (MD, λ⊥, and λ||) and magnetization transfer ratio (MTR)...
March 2018: Neurology® Neuroimmunology & Neuroinflammation
Robert C Bucelli, Alan Pestronk
Objective: Immune myopathies with perimysial pathology (IMPP) have a combination of damage to perimysial connective tissue and muscle fiber necrosis, more prominent near the perimysium. We studied the clinical and laboratory correlates of patients with pathologically defined IMPP. Methods: This is a retrospective chart and pathology review of 57 consecutive patients with IMPP myopathology and, for comparison, 20 patients with dermatomyositis with vascular pathology (DM-VP)...
March 2018: Neurology® Neuroimmunology & Neuroinflammation
Michael R Pranzatelli, Nathan R McGee
No abstract text is available yet for this article.
March 2018: Neurology® Neuroimmunology & Neuroinflammation
Amelia K Boehme, Mary E Comeau, Carl D Langefeld, Aaron Lord, Charles J Moomaw, Jennifer Osborne, Michael L James, Sharyl Martini, Fernando D Testai, Daniel Woo, Mitchell S V Elkind
Objective: Systemic inflammatory response syndrome (SIRS) may be related to poor outcomes after intracerebral hemorrhage (ICH). Methods: The Ethnic/Racial Variations of Intracerebral Hemorrhage study is an observational study of ICH in whites, blacks, and Hispanics throughout the United Sates. SIRS was defined by standard criteria as 2 or more of the following on admission: (1) body temperature <36°C or >38°C, (2) heart rate >90 beats per minute, (3) respiratory rate >20 breaths per minute, or (4) white blood cell count <4,000/mm3 or >12,000/mm3 ...
March 2018: Neurology® Neuroimmunology & Neuroinflammation
Maryam Nakhaei-Nejad, David Barilla, Chieh-Hsin Lee, Gregg Blevins, Fabrizio Giuliani
Objective: Lymphopenia is a common occurrence of disease-modifying therapies (DMTs) for relapsing-remitting MS (RRMS). The aim of this study was to dissect the prevalence of various lymphocyte subsets in patients with RRMS treated with 2 DMTs commonly associated with lymphopenia, dimethyl fumarate (DMF), and fingolimod (FTY). Methods: Multicolor flow cytometry and multiplex assays were used to identify up to 50 lymphocyte subpopulations and to examine the expression of multiple cytokines in selected patients...
March 2018: Neurology® Neuroimmunology & Neuroinflammation
Thomas Guerrier, Myriam Labalette, David Launay, Catalina Lee-Chang, Olivier Outteryck, Guillaume Lefèvre, Patrick Vermersch, Sylvain Dubucquoi, Hélène Zéphir
Objective: To assess whether any alteration of B-cell subset distribution and/or the cytokine production capacities of B cells could be associated with any stage of MS and could be predictive of MS evolution. Methods: We prospectively enrolled radiologically isolated syndrome (RIS), clinically isolated syndrome (CIS), naive patients with relapsing remitting MS (RRMS) of any disease modifying drug, and healthy controls (HCs). Peripheral blood B-cell subset distributions and the interleukin (IL)-6/IL-10-producing B-cell ratio were assessed by flow cytometry to evaluate their proinflammatory and anti-inflammatory functional properties...
March 2018: Neurology® Neuroimmunology & Neuroinflammation
Bart Swinnen, Steven Boeynaems, Maarten Schrooten, Veroniek Saegeman, Kristl G Claeys, Philip Van Damme
No abstract text is available yet for this article.
March 2018: Neurology® Neuroimmunology & Neuroinflammation
Iris Kleerekooper, Zoé L E van Kempen, Cyra E Leurs, Iris Dekker, Theo Rispens, Birgit I Lissenberg-Witte, Caspar E P van Munster, Brigit A de Jong, Bob W van Oosten, Bernard M J Uitdehaag, Mike P Wattjes, Joep Killestein
Objective: To investigate disease activity and disability progression following pregnancy-related discontinuation of natalizumab (NTZ) in patients with relapsing-remitting MS. Methods: A retrospective cohort study of clinical and radiologic data in patients who discontinued NTZ for pregnancy-related reasons. Results: Twenty-two pregnancy-related NTZ discontinuations in 17 patients were evaluated. The median time to conception was 3.4 months...
January 2018: Neurology® Neuroimmunology & Neuroinflammation
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