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Neurology® Neuroimmunology & Neuroinflammation

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https://www.readbyqxmd.com/read/29707611/monitoring-b-cell-repopulation-after-depletion-therapy-in-neurologic-patients
#1
Erik Ellwardt, Lea Ellwardt, Stefan Bittner, Frauke Zipp
Objective: To determine the factors that influence B-cell repopulation after B-cell depletion therapy in neurologic patients and derive recommendations for monitoring and dosing of patients. Methods: In this study, we determined the association of body surface area (BSA; calculated by body weight and height with the Dubois formula), sex, pretreatment therapy, age, CSF data, and white blood cell counts with the risk and timing of B-cell repopulation, defined as 1% CD19+ cells (of total lymphocytes), following 87 B cell-depleting anti-CD20 treatment cycles of 45 neurologic patients (28 women; mean age ± SD, 44...
July 2018: Neurology® Neuroimmunology & Neuroinflammation
https://www.readbyqxmd.com/read/29629397/obinutuzumab-a-potent-anti-b-cell-agent-for-rituximab-unresponsive-igm-anti-mag-neuropathy
#2
Goran Rakocevic, Ubaldo Martinez-Outschoorn, Marinos C Dalakas
No abstract text is available yet for this article.
July 2018: Neurology® Neuroimmunology & Neuroinflammation
https://www.readbyqxmd.com/read/29629396/anti-nmda-receptor-encephalitis-and-nonencephalitic-hsv-1-infection
#3
Amy Salovin, Jason Glanzman, Kylie Roslin, Thais Armangue, David R Lynch, Jessica A Panzer
Objective: To determine whether there is an association between nonencephalitic herpes simplex virus 1 (HSV-1) infection and anti-NMDA receptor encephalitis (anti-NMDARE). Methods: Antibody testing was performed using samples from 2 cohorts in a case-control observational study. The cohort "Philadelphia" included 16 serum samples of pediatric anti-NMDARE cases and 42 age-matched controls with other neuroinflammatory disorders studied at the Children's Hospital of Philadelphia and University of Pennsylvania...
July 2018: Neurology® Neuroimmunology & Neuroinflammation
https://www.readbyqxmd.com/read/29619403/fecal-microbiota-transplantation-associated-with-10-years-of-stability-in-a-patient-with-spms
#4
Seraj Makkawi, Carlos Camara-Lemarroy, Luanne Metz
No abstract text is available yet for this article.
July 2018: Neurology® Neuroimmunology & Neuroinflammation
https://www.readbyqxmd.com/read/29666841/erratum-dramatic-rebounds-of-ms-during-pregnancy-following-fingolimod-withdrawal
#5
(no author information available yet)
[This corrects the article on p. e377 in vol. 4, PMID: 28804745.].
May 2018: Neurology® Neuroimmunology & Neuroinflammation
https://www.readbyqxmd.com/read/29666840/looks-can-be-deceiving-a-b-cell-mediated-encephalopathy-with-normal-mri
#6
EDITORIAL
Josep Dalmau
No abstract text is available yet for this article.
May 2018: Neurology® Neuroimmunology & Neuroinflammation
https://www.readbyqxmd.com/read/29616234/diagnosing-mri-negative-autoimmune-diseases
#7
EDITORIAL
Carsten Finke
No abstract text is available yet for this article.
May 2018: Neurology® Neuroimmunology & Neuroinflammation
https://www.readbyqxmd.com/read/29616233/normal-brain-imaging-accompanies-neuroimmunologically-justified-autoimmune-encephalomyelitis
#8
Daiki Takewaki, Youwei Lin, Wakiro Sato, Hirohiko Ono, Masakazu Nakamura, Manabu Araki, Tomoko Okamoto, Yuji Takahashi, Yukio Kimura, Miho Ota, Noriko Sato, Takashi Yamamura
Objective: To examine cases with a clinical course, signs, and symptoms mimicking MS, but without abnormalities on conventional MRI. Methods: Among 550 people with a tentative diagnosis of MS or neuromyelitis optica spectrum disorder (NMOSD), we selected patients, who met the 2010 McDonald diagnosis criteria for MS, but did not show abnormal findings on conventional brain and spinal cord MRI. After evaluating their clinical data, we analyzed fractional anisotropy (FA) values in the brain white matter on diffusion tensor MRIs and the frequencies of B-cell subsets in the peripheral blood in the corresponding cases as compared to healthy controls...
May 2018: Neurology® Neuroimmunology & Neuroinflammation
https://www.readbyqxmd.com/read/29616232/pruritus-in-anti-dppx-encephalitis
#9
Juerd Wijntjes, Malik Bechakra, Marco W J Schreurs, Joost L M Jongen, Aart Koppenaal, Maarten J Titulaer
No abstract text is available yet for this article.
May 2018: Neurology® Neuroimmunology & Neuroinflammation
https://www.readbyqxmd.com/read/29564373/rituximab-before-and-during-pregnancy-a-systematic-review-and-a-case-series-in-ms-and-nmosd
#10
Gitanjali Das, Vincent Damotte, Jeffrey M Gelfand, Carolyn Bevan, Bruce A C Cree, Lynn Do, Ari J Green, Stephen L Hauser, Riley Bove
Objective: To evaluate the safety of rituximab treatment before and during pregnancy in women with MS and neuromyelitis optica spectrum disorders (NMOSDs) who may be at risk of relapses by performing a systematic literature review combined with a retrospective single-center case series. Methods: Studies were systematically identified in the PubMed, Google Scholar, and EMBASE using the key terms "pregnancy" and "rituximab"; 22 articles were included for review (>17,000 screened)...
May 2018: Neurology® Neuroimmunology & Neuroinflammation
https://www.readbyqxmd.com/read/29552598/multicenter-reliability-of-semiautomatic-retinal-layer-segmentation-using-oct
#11
Timm Oberwahrenbrock, Ghislaine L Traber, Sebastian Lukas, Iñigo Gabilondo, Rachel Nolan, Christopher Songster, Lisanne Balk, Axel Petzold, Friedemann Paul, Pablo Villoslada, Alexander U Brandt, Ari J Green, Sven Schippling
Objective: To evaluate the inter-rater reliability of semiautomated segmentation of spectral domain optical coherence tomography (OCT) macular volume scans. Methods: Macular OCT volume scans of left eyes from 17 subjects (8 patients with MS and 9 healthy controls) were automatically segmented by Heidelberg Eye Explorer (v1.9.3.0) beta-software (Spectralis Viewing Module v6.0.0.7), followed by manual correction by 5 experienced operators from 5 different academic centers...
May 2018: Neurology® Neuroimmunology & Neuroinflammation
https://www.readbyqxmd.com/read/29520367/architectural-b-cell-organization-in-skeletal-muscle-identifies-subtypes-of-dermatomyositis
#12
Josefine Radke, Randi Koll, Corinna Preuße, Debora Pehl, Kremena Todorova, Constanze Schönemann, Yves Allenbach, Eleonora Aronica, Marianne de Visser, Frank L Heppner, Joachim Weis, Soroush Doostkam, Thierry Maisonobe, Olivier Benveniste, Hans-Hilmar Goebel, Werner Stenzel
Objective: To study the B-cell content, organization, and existence of distinct B-cell subpopulations in relation to the expression of type 1 interferon signature related genes in dermatomyositis (DM). Methods: Evaluation of skeletal muscle biopsies from patients with adult DM (aDM) and juvenile DM (jDM) by histology, immunohistochemistry, electron microscopy, and quantitative reverse-transcription PCR. Results: We defined 3 aDM subgroups-classic (containing occasional B cells without clusters), B-cell-rich, and follicle-like aDM-further elucidating IM B-lymphocyte maturation and immunity...
May 2018: Neurology® Neuroimmunology & Neuroinflammation
https://www.readbyqxmd.com/read/29520366/microglial-activation-white-matter-tract-damage-and-disability-in-ms
#13
Eero Rissanen, Jouni Tuisku, Tero Vahlberg, Marcus Sucksdorff, Teemu Paavilainen, Riitta Parkkola, Johanna Rokka, Alexander Gerhard, Rainer Hinz, Peter S Talbot, Juha O Rinne, Laura Airas
Objective: To investigate the relationship of in vivo microglial activation to clinical and MRI parameters in MS. Methods: Patients with secondary progressive MS (n = 10) or relapsing-remitting MS (n = 10) and age-matched healthy controls (n = 17) were studied. Microglial activation was measured using PET and radioligand [11 C]( R )-PK11195. Clinical assessment and structural and quantitative MRI including diffusion tensor imaging (DTI) were performed for comparison...
May 2018: Neurology® Neuroimmunology & Neuroinflammation
https://www.readbyqxmd.com/read/29511707/thymectomy-lowers-the-myasthenia-gravis-biomarker-mir-150-5p
#14
Carl Johan Molin, Liis Sabre, Cleo-Aron Weis, Tanel Punga, Anna Rostedt Punga
Objective: The aim of the study was to analyze the effect of thymectomy on the proposed disease-specific microRNA (miRNA) biomarkers miR-150-5p and miR-21-5p in patients from the prospective randomized trial of thymectomy in myasthenia gravis (MGTX trial) and to evaluate the longitudinal changes in clinical patterns compared with these miRNA levels. Methods: Serum samples were obtained from 80 patients with MG who were included in the MGTX trial. Thirty-eight patients were randomized to thymectomy plus prednisone treatment, and 42 patients were randomized to prednisone treatment...
May 2018: Neurology® Neuroimmunology & Neuroinflammation
https://www.readbyqxmd.com/read/29511706/effective-treatment-of-clippers-with-long-term-use-of-rituximab
#15
Veronica P Cipriani, Nancy Arndt, Peter Pytel, Anthony T Reder, Adil Javed
No abstract text is available yet for this article.
May 2018: Neurology® Neuroimmunology & Neuroinflammation
https://www.readbyqxmd.com/read/29511705/treatment-choices-and-neuropsychological-symptoms-of-a-large-cohort-of-early-ms
#16
Olga von Bismarck, Theresa Dankowski, Björn Ambrosius, Nicole Hessler, Gisela Antony, Andreas Ziegler, Muna-Miriam Hoshi, Lilian Aly, Felix Luessi, Sergiu Groppa, Luisa Klotz, Sven G Meuth, Björn Tackenberg, Muriel Stoppe, Florian Then Bergh, Hayrettin Tumani, Tania Kümpfel, Martin Stangel, Christoph Heesen, Brigitte Wildemann, Friedemann Paul, Antonios Bayas, Clemens Warnke, Frank Weber, Ralf A Linker, Ulf Ziemann, Uwe K Zettl, Frauke Zipp, Heinz Wiendl, Bernhard Hemmer, Ralf Gold, Anke Salmen
Objective: To assess clinical characteristics, distribution of disease-modifying treatments (DMTs), and neuropsychological symptoms in a large cohort of patients with early-stage MS. Methods: The German National MS Cohort is a multicenter prospective longitudinal cohort study that has recruited DMT-naive patients with clinically isolated syndrome (CIS) and relapsing-remitting MS (RRMS) since 2010. We evaluated their baseline characteristics and the prevalence of neuropsychological symptoms...
May 2018: Neurology® Neuroimmunology & Neuroinflammation
https://www.readbyqxmd.com/read/29484308/short-lasting-unilateral-neuralgiform-headache-attacks-with-cranial-autonomic-symptoms-in-nmosd
#17
Yuri Mizuno, Koji Shinoda, Mitsuru Watanabe, Takuya Matsushita, Ryo Yamasaki, Jun-Ichi Kira
No abstract text is available yet for this article.
May 2018: Neurology® Neuroimmunology & Neuroinflammation
https://www.readbyqxmd.com/read/29464188/glycine-receptor-modulating-antibody-predicting-treatable-stiff-person-spectrum-disorders
#18
Shannon R Hinson, A Sebastian Lopez-Chiriboga, James H Bower, Joseph Y Matsumoto, Anhar Hassan, Eati Basal, Vanda A Lennon, Sean J Pittock, Andrew McKeon
Background: Glycine receptor alpha-1 subunit (GlyRα1)-immunoglobulin G (IgG) is diagnostic of stiff-person syndrome (SPS) spectrum but has been reported detectable in other neurologic diseases for which significance is less certain. Methods: To assess GlyRα1-IgGs as biomarkers of SPS spectrum among patients and controls, specimens were tested using cell-based assays (binding [4°C] and modulating [antigen endocytosing, 37°C]). Medical records of seropositive patients were reviewed...
March 2018: Neurology® Neuroimmunology & Neuroinflammation
https://www.readbyqxmd.com/read/29435472/cervical-spinal-cord-atrophy-an-early-marker-of-progressive-ms-onset
#19
Burcu Zeydan, Xinyi Gu, Elizabeth J Atkinson, B Mark Keegan, Brian G Weinshenker, Jan-Mendelt Tillema, Daniel Pelletier, Christina J Azevedo, Christine Lebrun-Frenay, Aksel Siva, Darin T Okuda, Kejal Kantarci, Orhun H Kantarci
Objective: To assess whether cervical spinal cord atrophy heralds the onset of progressive MS. Methods: We studied 34 individuals with radiologically isolated syndrome (RIS) and 31 patients with relapsing-remitting MS (RRMS) age matched to 25 patients within a year of onset of secondary progressive MS (SPMS). Two raters independently measured (twice per rater) the cervical spinal cord average segmental area (CASA) (mm2 ) of axial T2-weighted images between C2 and C7 landmarks...
March 2018: Neurology® Neuroimmunology & Neuroinflammation
https://www.readbyqxmd.com/read/29417957/erratum-progressive-inner-nuclear-layer-dysfunction-in-non-optic-neuritis-eyes-in-ms
#20
(no author information available yet)
[This corrects the article on p. e427 in vol. 5, PMID: 29259999.].
March 2018: Neurology® Neuroimmunology & Neuroinflammation
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