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Neurology® Neuroimmunology & Neuroinflammation

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https://www.readbyqxmd.com/read/30211253/varicella-zoster-virus-cns-vasculitis-and-rna-polymerase-iii-gene-mutation-in-identical-twins
#1
Madalina E Carter-Timofte, Anders F Hansen, Maibritt Mardahl, Sébastien Fribourg, Franck Rapaport, Shen-Ying Zhang, Jean-Laurent Casanova, Søren R Paludan, Mette Christiansen, Carsten S Larsen, Trine H Mogensen
Objective: Deficiency in the cytosolic DNA sensor RNA Polymerase III (POL III) was recently described in children with severe varicella-zoster virus (VZV) infection in the CNS or lungs. Here, we describe a pair of monozygotic female twins, who both experienced severe recurrent CNS vasculitis caused by VZV reactivation. The clinical presentation and findings included recurrent episodes of headache, dizziness, and neurologic deficits, CSF with pleocytosis and intrathecal VZV antibody production, and MRI of the brain showing ischemic lesions...
November 2018: Neurology® Neuroimmunology & Neuroinflammation
https://www.readbyqxmd.com/read/30211252/physical-activity-and-dentate-gyrus-volume-in-pediatric-acquired-demyelinating-syndromes
#2
Giulia Longoni, Robert A Brown, Berengere Aubert-Broche, Stephanie A Grover, Helen M Branson, Dumitru Fetco, Amit Bar-Or, Ruth Ann Marrie, Robert W Motl, D Louis Collins, Sridar Narayanan, Douglas L Arnold, Brenda Banwell, E Ann Yeh
Objective: To assess the association between daily moderate-to-vigorous physical activity (MVPA) and dentate gyrus volume (DGv) in pediatric patients with acquired demyelinating syndromes (ADSs) of the CNS. Methods: Cross-sectional analysis of accelerometry (7 days) and research protocol MRI data from 12 pediatric MS and 18 children with monophasic ADS (monoADS). Total brain and DGv were quantified using standardized methods. The association of daily minutes of MVPA with normalized DGv (nDGv) was assessed using multivariable generalized linear models...
November 2018: Neurology® Neuroimmunology & Neuroinflammation
https://www.readbyqxmd.com/read/30211251/population-based-study-of-no-evident-disease-activity-in-ms
#3
Natalie E Parks, Sean J Pittock, Jay Mandrekar, Orhun H Kantarci, Claudia F Lucchinetti, Brian G Weinshenker, B Mark Keegan, W Oliver Tobin, Jan-Mendelt Tillema, Michel Toledano, Eoin P Flanagan
Objective: To determine the persistence of no evident disease activity (NEDA) in a population-based relapsing-remitting MS (RRMS) cohort. Methods: All incident cases of RRMS in Olmsted County between 2000 and 2011 were identified using a medical records linkage system. Persistence of NEDA after RRMS diagnosis was determined by retrospective chart review. MRI activity, relapse, or Expanded Disability Status Scale (EDSS) worsening resulted in failure of NEDA. Results: We identified 93 incident cases of RRMS including 82 individuals with sufficient follow-up to determine the persistence of NEDA...
November 2018: Neurology® Neuroimmunology & Neuroinflammation
https://www.readbyqxmd.com/read/30175169/posttransplant-autoimmune-encephalitis
#4
Devon A Cohen, A Sebastian Lopez-Chiriboga, Sean J Pittock, Avi Gadoth, Anastasia Zekeridou, Barry A Boilson, William J Hogan, John J Poterucha, Katelynn M Wilton, Yi Lin, Eoin P Flanagan
No abstract text is available yet for this article.
November 2018: Neurology® Neuroimmunology & Neuroinflammation
https://www.readbyqxmd.com/read/30175168/of-primary-and-secondary-cns-autoimmunity
#5
EDITORIAL
Josep Dalmau
No abstract text is available yet for this article.
September 2018: Neurology® Neuroimmunology & Neuroinflammation
https://www.readbyqxmd.com/read/30175167/b-cell-depletion-is-ineffective-in-a-patient-with-granulomatous-optic-neuropathy
#6
Franziska Wagner, Helena Radbruch, Otto W Witte, Christian Geis
No abstract text is available yet for this article.
September 2018: Neurology® Neuroimmunology & Neuroinflammation
https://www.readbyqxmd.com/read/30175166/temporal-visual-resolution-and-disease-severity-in-ms
#7
Noah Ayadi, Jan Dörr, Seyedamirhosein Motamedi, Kay Gawlik, Judith Bellmann-Strobl, Janine Mikolajczak, Alexander U Brandt, Hanna Zimmermann, Friedemann Paul
Objective: To examine temporal visual resolution assessed as critical flicker frequency (CFF) in patients with MS and to investigate associations with visual system damage and general disability and cognitive function. Methods: Thirty-nine patients with MS and 31 healthy controls (HCs) were enrolled in this cross-sectional study and underwent CFF testing, high- and low-contrast visual acuity, alertness and information processing speed using the paced auditory serial addition task (PASAT), and retinal optical coherence tomography (OCT)...
September 2018: Neurology® Neuroimmunology & Neuroinflammation
https://www.readbyqxmd.com/read/30175165/identification-of-ms-specific-serum-mirnas-in-an-international-multicenter-study
#8
Keren Regev, Brian C Healy, Anu Paul, Camilo Diaz-Cruz, Maria Antonietta Mazzola, Radhika Raheja, Bonnie I Glanz, Pia Kivisäkk, Tanuja Chitnis, Maja Jagodic, Fredrik Piehl, Tomas Olsson, Mohsen Khademi, Stephen Hauser, Jorge Oksenberg, Samia J Khoury, Howard L Weiner, Roopali Gandhi
Objective: To identify circulating microRNAs (miRNAs) linked to disease, disease stage, and disability in MS across cohorts. Methods: Samples were obtained from the Comprehensive Longitudinal Investigation of Multiple Sclerosis (CLIMB, Boston, MA), EPIC (San Francisco, CA), AMIR (Beirut, Lebanon) as part of the SUMMIT consortium, and Stockholm Prospective Assessment of Multiple Sclerosis (Stockholm, Sweden) cohorts. Serum miRNA expression was measured using locked nucleic acid-based quantitative PCR...
September 2018: Neurology® Neuroimmunology & Neuroinflammation
https://www.readbyqxmd.com/read/30175164/characteristics-of-optic-neuropathy-in-beh%C3%A3-et-disease
#9
Gülden Akdal, Hülya Ertaşoğlu Toydemir, Ali Osman Saatci, Uğur Uygunoğlu, Burcu Altunrende, Sabahattin Saip, Aylin Yaman, Pembe Keskinoğlu, Suzan Güven Yilmaz, Neşe Çelebisoy, Meltem Söylev Bajin, Aksel Siva, Gülşen Akman-Demir
Objective: We present the clinical profile, features, and neuroimaging findings of 25 patients with Behçet disease (BD), and optic neuropathy (ON), which has been rarely reported in BD. Methods: Data from 5 university hospitals were retrospectively reviewed, and patients with BD and ON were evaluated. There were 2 groups: (1) those already diagnosed with BD when ON developed (BD → ON group) and (2) those diagnosed with BD during the evaluation of ON (ON → BD group)...
September 2018: Neurology® Neuroimmunology & Neuroinflammation
https://www.readbyqxmd.com/read/30175163/further-reducing-terra-incognita-on-the-map-of-synaptic-autoimmunity
#10
EDITORIAL
Harald Prüss
No abstract text is available yet for this article.
September 2018: Neurology® Neuroimmunology & Neuroinflammation
https://www.readbyqxmd.com/read/30175162/microscopic-polyangiitis-after-alemtuzumab-treatment-in-relapsing-remitting-ms
#11
Eva-Maria Sauer, Stefan Schliep, Bernhard Manger, De-Hyung Lee, Ralf A Linker
No abstract text is available yet for this article.
September 2018: Neurology® Neuroimmunology & Neuroinflammation
https://www.readbyqxmd.com/read/30175161/immunotherapy-responsive-dorsal-column-myelopathy-in-a-patient-with-asymptomatic-celiac-disease
#12
Michael J Bradshaw, Golnaz Yadollahikhales, Nagagopal Venna
No abstract text is available yet for this article.
September 2018: Neurology® Neuroimmunology & Neuroinflammation
https://www.readbyqxmd.com/read/30175160/raised-vegf-high-sensitivity-and-specificity-in-the-diagnosis-of-poems-syndrome
#13
Morgane Pihan, Stephen Keddie, Shirley D'Sa, Andrew J Church, Kwee L Yong, Mary M Reilly, Michael P Lunn
Objective: To investigate the sensitivity and the specificity of serum vascular endothelial growth factor (sVEGF) for the diagnosis of polyneuropathy, organomegaly, endocrinopathy, M-protein, and skin changes (POEMS) syndrome in patients with a neuropathy (NP) and to identify confounding causes of raised vascular endothelial growth factor (VEGF) in this context to improve accuracy. Methods: We studied the specificity and sensitivity of sVEGF for the diagnosis of POEMS syndrome in a cohort of 195 consecutive patients with an NP in serum samples from June 2009 to November 2013, including 27 untreated patients with POEMS syndrome...
September 2018: Neurology® Neuroimmunology & Neuroinflammation
https://www.readbyqxmd.com/read/30175159/subacute-encephalitis-with-recovery-in-iglon5-autoimmunity
#14
Vijay K Ramanan, Brian A Crum, Andrew McKeon
No abstract text is available yet for this article.
September 2018: Neurology® Neuroimmunology & Neuroinflammation
https://www.readbyqxmd.com/read/30038948/gd-contrast-administration-is-dispensable-in-patients-with-ms-without-new-t2-lesions-on-follow-up-mri
#15
Kianush Karimian-Jazi, Brigitte Wildemann, Ricarda Diem, Daniel Schwarz, Thomas Hielscher, Wolfgang Wick, Martin Bendszus, Michael O Breckwoldt
Objective: To assess the diagnostic value of gadolinium (Gd) contrast administration in MRI follow-up examinations of patients with MS if the T2 lesion load is stable. Methods: We included 100 patients with MS with at least 2 cranial MRI follow-up examinations (mean follow-up time 4.0 ± 2.6 years). MRI was performed at 3 Tesla with a standardized protocol including T2-weighted, fluid-attenuated inversion recovery (FLAIR) and T1-weighted contrast-enhanced sequences...
September 2018: Neurology® Neuroimmunology & Neuroinflammation
https://www.readbyqxmd.com/read/30027107/intracerebral-lymphoproliferative-disorder-in-an-ms-patient-treated-with-fingolimod
#16
Brigit A de Jong, Zoé L E van Kempen, Mike P Wattjes, Patrick M Smit, Laura Peferoen, Daniella Berry, Martine E D Chamuleau, Daphne de Jong
No abstract text is available yet for this article.
September 2018: Neurology® Neuroimmunology & Neuroinflammation
https://www.readbyqxmd.com/read/30027106/gfap%C3%AE-igg-associated-encephalitis-upon-daclizumab-treatment-of-ms
#17
Felix Luessi, Sinah Engel, Annette Spreer, Stefan Bittner, Frauke Zipp
Objective: To describe a case of glial fibrillary acidic protein (GFAP)α immunoglobulin G (IgG)-associated encephalitis in a patient referred to us with MS on daclizumab treatment and to summarize characteristics of 5 additional recent German MS cases of serious encephalitis along with a previously published American case of CNS vasculitis associated with daclizumab. Methods: Evaluation of cause, clinical symptoms, and treatment response. Results: The 6 patients included 4 women and 2 men...
September 2018: Neurology® Neuroimmunology & Neuroinflammation
https://www.readbyqxmd.com/read/30027105/drug-reaction-with-eosinophilia-and-systemic-symptoms-after-daclizumab-therapy-in-ms
#18
Franziska Scheibe, Imke Metz, Helena Radbruch, Eberhard Siebert, Stefan Wolf, Martin Köhnlein, Lutz Harms, Andreas Meisel
No abstract text is available yet for this article.
September 2018: Neurology® Neuroimmunology & Neuroinflammation
https://www.readbyqxmd.com/read/30027104/cladribine-tablets-added-to-ifn-%C3%AE-in-active-relapsing-ms-the-onward-study
#19
Xavier Montalban, Thomas P Leist, Bruce A Cohen, Harold Moses, Jackie Campbell, Christine Hicking, Fernando Dangond
Objective: To evaluate the safety and efficacy of cladribine tablets in patients still experiencing active relapsing MS despite interferon (IFN)-β treatment. Methods: A 96-week phase II study, randomizing patients treated with IFN-β to cladribine tablets 3.5 mg/kg/IFN-β or placebo/IFN-β. Patients were to receive cladribine tablets 3.5 mg/kg/IFN-β or placebo/IFN-β in a 2:1 ratio (n = 172) with safety and exploratory efficacy outcomes being assessed. Results: Adverse events (AEs) and serious AEs were similar across treatment groups, except lymphopenia...
September 2018: Neurology® Neuroimmunology & Neuroinflammation
https://www.readbyqxmd.com/read/29998159/tumefactive-demyelination-with-a-transient-appearance-of-oligoclonal-bands-in-ms-under-fingolimod
#20
Kazumasa Okada, Tomoyo Hashimoto, Masako Kobata, Shingo Kakeda, Toshiyuki Takahashi, Junko Hirato
No abstract text is available yet for this article.
September 2018: Neurology® Neuroimmunology & Neuroinflammation
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