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Immunity, Inflammation and Disease

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https://www.readbyqxmd.com/read/29027376/adenosine-a2a-receptor-agonist-ameliorates-eae-and-correlates-with-th1-cytokine-induced-blood-brain-barrier-dysfunction-via-suppression-of-mlck-signaling-pathway
#1
Ying Liu, Marwan Alahiri, Bianca Ulloa, Boxun Xie, Saud A Sadiq
INTRODUCTION: Multiple sclerosis (MS) disease activity is associated with blood-brain barrier (BBB) disruption, which is mediated by inflammatory cytokines released by CD4+ lymphocytes. To assess the effects of adenosine A2A receptors on BBB permeability in vitro and in vivo. METHODS: A2A receptor expression was detected by immunostaining in experimental autoimmune encephalomyelitis (EAE) C57BL/6 mice immunized with myelin oligodendrocyte glycoprotein (MOG)35-55 , and human MS brain...
October 12, 2017: Immunity, Inflammation and Disease
https://www.readbyqxmd.com/read/28967702/a-snp-uncoupling-mina-expression-from-the-tgf%C3%AE-signaling-pathway
#2
Shang L Lian, Belgacem Mihi, Madoka Koyanagi, Toshinori Nakayama, Mark Bix
INTRODUCTION: Mina is a JmjC family 2-oxoglutarate oxygenase with pleiotropic roles in cell proliferation, cancer, T cell differentiation, pulmonary inflammation, and intestinal parasite expulsion. Although Mina expression varies according to cell-type, developmental stage and activation state, its transcriptional regulation is poorly understood. Across inbred mouse strains, Mina protein level exhibits a bimodal distribution, correlating with inheritance of a biallelic haplotype block comprising 21 promoter/intron 1-region SNPs...
October 2, 2017: Immunity, Inflammation and Disease
https://www.readbyqxmd.com/read/28967229/t-cells-responding-to-trypanosoma-cruzi-detected-by-membrane-tnf-%C3%AE-and-cd154-in-chagasic-patients
#3
Juan G Ripoll, Nicolás A Giraldo, Natalia I Bolaños, Nubia Roa, Fernando Rosas, Adriana Cuéllar, Concepción J Puerta, John M González
INTRODUCTION: Chagas disease is a parasitic infection whose pathogenesis is related to parasite persistence and a dysfunctional cellular immune response. Variability in cytokine secretion among chronic Trypanosoma cruzi-infected patients might preclude the identification of the pool of antigen specific T cells. The goal of this study was to determine the fraction of T cells responding to T. cruzi antigen measured by the expression of membrane TNF-α and CD154. METHODS: A total of 21 chagasic patients, 11 healthy and 5 non-chagasic cardiomyopathy controls were analyzed...
October 1, 2017: Immunity, Inflammation and Disease
https://www.readbyqxmd.com/read/28952190/il-12-and-il-15-induce-the-expression-of-cxcr6-and-cd49a-on-peripheral-natural-killer-cells
#4
Theresa Hydes, Angela Noll, Gabriela Salinas-Riester, Mohammed Abuhilal, Thomas Armstrong, Zaed Hamady, John Primrose, Arjun Takhar, Lutz Walter, Salim I Khakoo
INTRODUCTION: Murine hepatic NK cells exhibit adaptive features, with liver-specific adhesion molecules CXCR6 and CD49a acting as surface markers. METHODS: We investigated human liver-resident CXCR6+ and CD49a+ NK cells using RNA sequencing, flow cytometry, and functional analysis. We further assessed the role of cytokines in generating NK cells with these phenotypes from the peripheral blood. RESULTS: Hepatic CD49a+ NK cells could be induced using cytokines and produce high quantities of IFNγ and TNFα, in contrast to hepatic CXCR6+ NK cells...
September 27, 2017: Immunity, Inflammation and Disease
https://www.readbyqxmd.com/read/28840646/performance-of-an-allele-level-multi-locus-hla-genotype-imputation-tool-in-hematopoietic-stem-cell-donors-from-quebec
#5
Abdelhakim Ferradji, Yasmin D'Souza, Chee Loong Saw, Karim Oualkacha, Lucie Richard, Ruth Sapir-Pichhadze
INTRODUCTION: Donor-recipient HLA compatibility is an important determinant of transplant outcomes. Allele-group to allele-level imputations help assign HLA genotypes when allele-level genotypes are not available during donor selection. METHODS: We evaluated the performance of HaploStats, an allele-level multi-locus HLA genotype imputation tool from the National Marrow Donor Program, in a cross-sectional study including hematopoietic stem cell donors (HSCD) from Quebec, Canada...
August 25, 2017: Immunity, Inflammation and Disease
https://www.readbyqxmd.com/read/28805308/lymphocyte-profile-and-cytokine-mrna-expression-in-peripheral-blood-mononuclear-cells-of-patients-with-recurrent-respiratory-papillomatosis-suggest-dysregulated-cytokine-mrna-response-and-impaired-cytotoxic-capacity
#6
Anna Holm, Olga Nagaeva, Ivan Nagaev, Christos Loizou, Göran Laurell, Lucia Mincheva-Nilsson, Karin Nylander, Katarina Olofsson
OBJECTIVES: Recurrent respiratory papillomatosis (RRP) is a relatively rare, chronic disease caused by Human Papilloma Virus (HPV) 6 and 11, and characterized by wart-like lesions in the airway affecting voice and respiratory function. The majority of HPV infections are asymptomatic and resolve spontaneously, however, some individuals are afflicted with persistent HPV infections. Failure to eliminate HPV 6 and 11 due to a defect immune responsiveness to these specific genotypes is proposed to play a major role in the development of RRP...
August 14, 2017: Immunity, Inflammation and Disease
https://www.readbyqxmd.com/read/28776958/transgenic-mice-with-ectopic-expression-of-constitutively-active-tlr4-in-adipose-tissues-do-not-show-impaired-insulin-sensitivity
#7
Kikumi D Ono-Moore, Ling Zhao, Shurong Huang, Jeonga Kim, Jennifer M Rutkowsky, Ryan G Snodgrass, Dina A Schneider, Michael J Quon, James L Graham, Peter J Havel, Daniel H Hwang
INTRODUCTION: Chronic low-grade inflammation is associated with obesity and diabetes. However, what causes and mediates chronic inflammation in metabolic disorders is not well understood. Toll-like receptor 4 (TLR4) mediates both infection-induced and sterile inflammation by recognizing pathogen-associated molecular patterns and endogenous molecules, respectively. Saturated fatty acids can activate TLR4, and TLR4-deficient mice were protected from high fat diet (HFD)-induced obesity and insulin resistance, suggesting that TLR4-mediated inflammation may cause metabolic dysfunction, such as obesity and insulin resistance...
August 4, 2017: Immunity, Inflammation and Disease
https://www.readbyqxmd.com/read/28836739/corrigendum
#8
(no author information available yet)
Baïz, N., Chastang, J., Ibanez, G., & Annesi-Maesano I. (2016). Prenatal exposure to selenium may protect against wheezing in children by the age of 3. Immunity, Inflammation and Disease, 5 (1), 37-44. DOI: 10.1002/iid3.138. In the article "Prenatal exposure to selenium may protect against wheezing in children by the age of 3", it has been noted that the 'EDEN Mother-Child Cohort Study Group was omitted in error. The correct author list for the article is shown below. Nour Baïz(1) , Julie Chastang(1,2) , Gladys Ibanez(1,2) , Isabella Annesi-Maesano(1) and the EDEN Mother-Child Cohort Study Group(3) ...
September 2017: Immunity, Inflammation and Disease
https://www.readbyqxmd.com/read/28548248/the-emerging-role-of-interleukin-37-in-cardiovascular-diseases
#9
REVIEW
Xinyu Zhuang, Bangwei Wu, Jian Li, Haiming Shi, Bo Jin, Xinping Luo
INTRODUCTION: Interleukin (IL)-37 is a newly identified member of the IL-1 family, and shows a growing role in a variety of diseases. This review aims at summarizing and discussing the role of IL-37 in cardiovascular diseases. METHODS: Data for this review were identified by searches of MEDLINE, Embase, and PubMed using appropriate search terms. RESULTS: IL-37 is a newly identified cytokine belonging to the IL-1 family and is expressed in inflammatory immune cells and several parenchymal cells...
September 2017: Immunity, Inflammation and Disease
https://www.readbyqxmd.com/read/28544689/class-ii-obese-and-healthy-pregnant-controls-exhibit-indistinguishable-pro-and-anti-inflammatory-immune-responses-to-caesarian-section
#10
Caroline Graham, Mullein Thorleifson, William P Stefura, Duane J Funk, Kent T HayGlass
INTRODUCTION: Obesity during pregnancy is associated with meta-inflammation and an increased likelihood of clinical complications. Surgery results in intense, acute inflammatory responses in any individual. Because obese individuals exhibit constitutive inflammatory responses and high rates of Caesarian section, it is important to understand the impact of surgery in such populations. Whether more pronounced pro-inflammatory cytokine responses and/or counterbalancing changes in anti-inflammatory immune modulators occurs is unknown...
September 2017: Immunity, Inflammation and Disease
https://www.readbyqxmd.com/read/28544524/increase-of-cells-expressing-pd-1-and-pd-l1-and-enhancement-of-ifn-%C3%AE-production-via-pd-1-pd-l1-blockade-in-bovine-mycoplasmosis
#11
Shinya Goto, Satoru Konnai, Tomohiro Okagawa, Asami Nishimori, Naoya Maekawa, Satoshi Gondaira, Hidetoshi Higuchi, Masateru Koiwa, Motoshi Tajima, Junko Kohara, Satoshi Ogasawara, Yukinari Kato, Yasuhiko Suzuki, Shiro Murata, Kazuhiko Ohashi
INTRODUCTION: Bovine mycoplasma, chiefly Mycoplasma bovis, is a pathogen that causes pneumonia, mastitis, arthritis, and otitis media in cattle. This pathogen exerts immunosuppressive effects, such as the inhibition of interferon production. However, the mechanisms involved in bovine mycoplasmosis have not been fully elucidated. In this study, we investigated the role of the programmed death-1 (PD-1)/programmed death-ligand 1 (PD-L1) pathway in immunosuppression in bovine mycoplasmosis...
September 2017: Immunity, Inflammation and Disease
https://www.readbyqxmd.com/read/28508570/a-new-transcript-in-the-tcrb-locus-unveils-the-human-ortholog-of-the-mouse-pre-d%C3%A3-1-promoter
#12
Bernard Lethé, Sylvia Snauwaert, Orian Bricard, David Schröder, Tiphanie Gomard, Gérald Hames, Catherine Muller, Christophe Lurquin, Emilie Gauthy, Ahmed Essaghir, Bart Vandekerckhove, Pierre G Coulie
INTRODUCTION: While most transcripts arising from the human T Cell Receptor locus reflect fully rearranged genes, several germline transcripts have been identified. We describe a new germline transcript arising from the human TCRB locus. METHODS: cDNA sequencing, promoter, and gene expression analyses were used to characterize the new transcript. RESULTS: The new germline transcript encoded by the human TCRB locus consists of a new exon of 103 bp, which we named TRBX1 (X1), spliced with the first exon of gene segments Cß1 or Cß2...
September 2017: Immunity, Inflammation and Disease
https://www.readbyqxmd.com/read/28508554/intestinal-epithelial-suppressor-of-cytokine-signaling-3-socs3-impacts-on-mucosal-homeostasis-in-a-model-of-chronic-inflammation
#13
Elisabeth J Shaw, Emily E Smith, Jayde Whittingham-Dowd, Matthew D Hodges, Kathryn J Else, Rachael J Rigby
INTRODUCTION: Suppressor of cytokine signaling 3 (SOCS3) is a tumour suppressor, limiting intestinal epithelial cell (IEC) proliferation in acute inflammation, and tumour growth, but little is known regarding its role in mucosal homeostasis. Resistance to the intestinal helminth Trichuris muris relies on an "epithelial escalator" to expel the parasite. IEC turnover is restricted by parasite-induced indoleamine 2,3-dioxygenase (IDO). METHODS: Mice with or without conditional knockout of SOCS3 were infected with T...
September 2017: Immunity, Inflammation and Disease
https://www.readbyqxmd.com/read/28508444/increased-adipose-tissue-expression-of-il-18r-and-its-ligand-il-18-associates-with-inflammation-and-insulin-resistance-in-obesity
#14
Rasheed Ahmad, Reeby Thomas, Shihab Kochumon, Sardar Sindhu
INTRODUCTION: The proinflammatory cytokine IL-18 is involved in the pathogenesis of metabolic syndrome. While the changes in IL-18 are known, IL-18R expression and relationship with IL-18 and other inflammatory markers in the adipose tissue in obesity/type-2 diabetes (T2D) remain unclear. METHODS: We, therefore, determined the adipose tissue expression of IL-18R and IL-18 mRNA/protein in lean, overweight, and obese individuals with and without T2D, 15 each, using qRT-PCR, immunohistochemistry, and confocal microscopy...
September 2017: Immunity, Inflammation and Disease
https://www.readbyqxmd.com/read/28497614/broad-th2-neutralization-and-anti-inflammatory-action-of-pentosan-polysulfate-sodium-in-experimental-allergic-rhinitis
#15
Caroline Sanden, Michiko Mori, Prajakta Jogdand, Jimmie Jönsson, Ravi Krishnan, Xiangdong Wang, Jonas S Erjefält
BACKGROUND: Th2 cytokines like interleukin-4, -5, and -13 are regarded as important drivers of the immunopathology underlying allergic rhinitis (AR) and asthma. The present study explores the capacity of pentosan polysulfate sodium (PPS), a semi-synthetic heparin-like macromolecular carbohydrate, to bind Th2 cytokines and exert biological neutralization in vitro, as well as anti-inflammatory actions in vivo. METHODOLOGY: The capacity of PPS to bind recombinant Th2 cytokines was tested with surface plasmon resonance (SPR) technology and biological Th2 neutralization was assessed by Th2-dependent proliferation assays...
September 2017: Immunity, Inflammation and Disease
https://www.readbyqxmd.com/read/28497586/r-ras-deficiency-does-not-affect-papain-induced-ige-production-in-mice
#16
Laura Kummola, Zsuzsanna Ortutay, Maria Vähätupa, Stuart Prince, Hannele Uusitalo-Järvinen, Tero A H Järvinen, Ilkka S Junttila
INTRODUCTION: R-Ras GTPase has recently been implicated in the regulation of immune functions, particularly in dendritic cell (DC) maturation, immune synapse formation, and subsequent T cell responses. METHODS: Here, we investigated the role of R-Ras in allergen-induced immune response (type 2 immune response) in Rras deficient (R-Ras KO) and wild type (WT) mice. RESULTS: Initially, we found that the number of conventional DC's in the lymph nodes (LNs) was reduced in R-Ras KO mice...
September 2017: Immunity, Inflammation and Disease
https://www.readbyqxmd.com/read/28497578/effector-and-regulatory-dendritic-cells-display-distinct-patterns-of-mirna-expression
#17
Vincent Lombardi, Sonia Luce, Hélène Moussu, Lise Morizur, Claire Gueguen, Catherine Neukirch, Sylvie Chollet-Martin, Laurent Mascarell, Michel Aubier, Véronique Baron-Bodo, Philippe Moingeon
INTRODUCTION: MicroRNAs (miRNAs) contribute to the regulation of dendritic cell (DC) polarization, thereby influencing the balance of adaptive immune responses. Herein, we studied the expression of miRNAs in polarized DCs and analyzed whether expression of these miRNAs could be associated with allergic rhinitis and allergen immunotherapy (AIT) outcome. METHOD: Using specific culture conditions, we differentiated immature human monocyte-derived DCs into DC1, DC2, and DCreg subsets (supporting the differentiation of TH 1, TH 2 or regulatory T cells, respectively)...
September 2017: Immunity, Inflammation and Disease
https://www.readbyqxmd.com/read/28493442/upa-derived-peptide-%C3%A3-6-is-involved-in-the-suppression-of-lipopolysaccaride-promoted-inflammatory-osteoclastogenesis-and-the-resultant-bone-loss
#18
Yosuke Kanno, Chihiro Maruyama, Ayaka Matsuda, Akira Ishisaki
INTRODUCTION: Chronic inflammatory diseases such as rheumatoid arthritis and periodontitis frequently cause bone destruction. Inflammation-induced bone loss results from the increase of bone-resorbing osteoclasts. Recently, we demonstrated that urokinase type plasminogen activator (uPA) suppressed lipopolysaccaride (LPS)-inflammatory osteoclastogenesis through the adenosine monophosphate-activated protein kinase (AMPK) pathway, whereas its receptor (uPAR) promoted that through the Akt pathway...
September 2017: Immunity, Inflammation and Disease
https://www.readbyqxmd.com/read/28480538/glucuronides-of-phytoestrogen-flavonoid-enhance-macrophage-function-via-conversion-to-aglycones-by-%C3%AE-glucuronidase-in-macrophages
#19
Atsushi Kaneko, Takashi Matsumoto, Yosuke Matsubara, Kyoji Sekiguchi, Junichi Koseki, Ryo Yakabe, Katsuyuki Aoki, Setsuya Aiba, Kenshi Yamasaki
INTRODUCTION: Flavonoids are converted to inactive metabolites like glucuronides in the gut, and circulate mainly as glucuronides in blood stream, resulting in low concentrations of active aglycones in plasma. It is therefore unclear how oral flavonoids exert their effects in tissues. We recently reported the plasma pharmacokinetics of some flavonoids and suggested the possibility that the absorbed flavonoids modified macrophage functions leading to enhance bacterial clearance. We aimed to confirm their pharmacological profiles focusing on tissue macrophages...
September 2017: Immunity, Inflammation and Disease
https://www.readbyqxmd.com/read/28474861/group-2-innate-lymphoid-cells-are-elevated-and-activated-in-chronic-rhinosinusitis-with-nasal-polyps
#20
Julie A Poposki, Aiko I Klingler, Bruce K Tan, Pejman Soroosh, Homayon Banie, Gavin Lewis, Kathryn E Hulse, Whitney W Stevens, Anju T Peters, Leslie C Grammer, Robert P Schleimer, Kevin C Welch, Stephanie S Smith, David B Conley, Joseph R Raviv, James G Karras, Omid Akbari, Robert C Kern, Atsushi Kato
BACKGROUND: Chronic rhinosinusitis (CRS) with nasal polyps (CRSwNP) is characterized by type 2 inflammation with high levels of Th2 cytokines. Although T helper cytokines are released from T cells, innate lymphoid cells (ILC) are also known to produce high levels of the same cytokines. However, the presence of various types of ILC in CRS is poorly understood. OBJECTIVE: The objective of this study was to fully characterize the presence of all ILC subsets in CRS and to identify phenotypical differences of group 2 ILC (ILC2) in CRSwNP compared to ILC2 from non-type 2 inflamed areas...
September 2017: Immunity, Inflammation and Disease
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