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Immunity, Inflammation and Disease

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https://www.readbyqxmd.com/read/29642283/hyperglycaemia-is-inversely-correlated-with-live-m-bovis-bcg-specific-cd4-t-cell-responses-in-tanzanian-adults-with-latent-or-active-tuberculosis
#1
Noémie Boillat-Blanco, Anneth-Mwasi N Tumbo, Matthieu Perreau, Patrizia Amelio, Kaushik L Ramaiya, Maliwaza Mganga, Christian Schindler, Sebastien Gagneux, Klaus Reither, Nicole Probst-Hensch, Giuseppe Pantaleo, Claudia Daubenberger, Damien Portevin
INTRODUCTION: The rising prevalence of Diabetes mellitus (DM) in high TB-endemic countries may adversely affect sustainability of TB control since DM constitutes a risk factor for development of active tuberculosis (TB). The impact of DM on TB specific adaptive immune responses remains poorly addressed, particularly in people living in Sub-Saharan countries. We performed a functional characterization of TB specific cellular immune response in Tanzanian subjects with active or latent Mycobacterium tuberculosis (Mtb) infection stratified by their diabetic status...
April 11, 2018: Immunity, Inflammation and Disease
https://www.readbyqxmd.com/read/29642282/effect-of-the-s-nitrosoglutathione-reductase-inhibitor-n6022-on-bronchial-hyperreactivity-in-asthma
#2
Loretta G Que, Zhonghui Yang, Njira L Lugogo, Rohit K Katial, Steven A Shoemaker, Janice M Troha, David M Rodman, Robert M Tighe, Monica Kraft
RATIONALE: Patients with asthma demonstrate depletion of the endogenous bronchodilator GSNO and upregulation of GSNOR. OBJECTIVES: An exploratory proof of concept clinical study of N6022 in mild asthma to determine the potential bronchoprotective effects of GSNOR inhibition. Mechanistic studies aimed to provide translational evidence of effect. METHODS: Fourteen mild asthma patients were treated with intravenous N6022 (5 mg) or placebo and observed for 7 days, with repeated assessments of the provocative dose of methacholine causing a 20% fall in FEV1 (methacholine PC20 FEV1), followed by a washout period and crossover treatment and observation...
April 11, 2018: Immunity, Inflammation and Disease
https://www.readbyqxmd.com/read/29642281/fas-ligand-localizes-to-intraluminal-vesicles-within-nk-cell-cytolytic-granules-and-is-enriched-at-the-immune-synapse
#3
Jeansun Lee, Nele M G Dieckmann, James R Edgar, Gillian M Griffiths, Richard M Siegel
INTRODUCTION: T cell and NK cell cytotoxicity can be mediated via the perforin/granzyme system and Fas Ligand (FasL, CD178). FasL is synthesized as a type II transmembrane protein that binds its cognate receptor Fas (CD95). Membrane-bound FasL is expressed on the plasma membrane of activated lymphocytes and is the main form of FasL with cytotoxic activity, but whether FasL is delivered to the immune synapse along with granzyme and perforin-containing granules is unclear. METHODS: We stably expressed FasL-fluorescent fusion proteins into human NK cells and examined the localization of FasL relative to other intracellular markers by confocal and immunoelectron microscopy, and examined the trafficking of FasL during formation of immune synapses with HLA-deficient B cells...
April 11, 2018: Immunity, Inflammation and Disease
https://www.readbyqxmd.com/read/29635889/neural-architecture-in-lymphoid-organs-hard-wired-antigen-presenting-cells-and-neurite-networks-in-antigen-entrance-areas
#4
Clemens Wülfing, Fenja Amrei Schuran, Julia Urban, Jasmin Oehlmann, Hauke Simon Günther
INTRODUCTION: Recently, we found abundant innervation of antigen presenting cells that were reached and enclosed by single neurites. These neurally hard-wired antigen presenting cells (wAPC) could be observed in the T-cell zone of superficial cervical lymph nodes of rats and other mammalians, including humans. METHODS: As a consequence, we investigated lymph nodes at many different anatomical positions as well as all primary and secondary lymphoid organs (SLO) in rodents for a similar morphology of innervation regarding antigen presenting cells known in those tissues...
April 10, 2018: Immunity, Inflammation and Disease
https://www.readbyqxmd.com/read/29602245/reactive-glia-promote-development-of-cd103-cd69-cd8-t-cells-through-programmed-cell-death-ligand-1-pd-l1
#5
Sujata Prasad, Shuxian Hu, Wen S Sheng, Priyanka Chauhan, James R Lokensgard
INTRODUCTION: Previous work from our laboratory has demonstrated in vivo persistence of CD103+ CD69+ brain resident memory CD8+ T-cells (bTRM ) following viral infection, and that the PD-1: PD-L1 pathway promotes development of these TRM cells within the brain. Although glial cells express low basal levels of PD-L1, its expression is upregulated upon IFN-γ-treatment, and they have been shown to modulate antiviral T-cell effector responses through the PD-1: PD-L1 pathway. METHODS: We performed flow cytometric analysis of cells from co-cultures of mixed glia and CD8+ T-cells obtained from wild type mice to investigate the role of glial cells in the development of bTRM ...
March 30, 2018: Immunity, Inflammation and Disease
https://www.readbyqxmd.com/read/29575717/benefits-of-antifungal-therapy-in-asthma-patients-with-airway-mycosis-a-retrospective-cohort-analysis
#6
Evan Li, Chu-Lin Tsai, Zahida K Maskatia, Ekta Kakkar, Paul Porter, Roger D Rossen, Sarah Perusich, John M Knight, Farrah Kheradmand, David B Corry
INTRODUCTION: Fungal airway infection (airway mycosis) is increasingly recognized as a cause of asthma and related disorders. However, prior controlled studies of patients treated with antifungal antibiotics have produced conflicting results. Our objective is to measure the effect of antifungal therapy in moderate to severe adult asthmatics with positive fungal sputum cultures in a single center referral-based academic practice. METHODS: We retrospectively evaluated 41 patients with asthma and culture-proven airway mycosis treated with either terbinafine, fluconazole, itraconazole, voriconazole, or posaconazole for 4 to >12 weeks together with standard bronchodilator and anti-inflammatory agents...
March 25, 2018: Immunity, Inflammation and Disease
https://www.readbyqxmd.com/read/29542272/pathways-of-airway-oxidant-formation-by-house-dust-mite-allergens-and-viral-rna-converge-through-myosin-motors-pannexons-and-toll-like-receptor-4
#7
Jihui Zhang, Jie Chen, Shannon C Mangat, Chathuri Perera Baruhupolage, David R Garrod, Clive Robinson
INTRODUCTION: Intracellular reactive oxidant species (ROS) are generated in human airway epithelial cells by the prothrombinase action of Group 1 house dust mite (HDM) allergens and by ligation of viral RNA sensor Toll-like receptors (TLRs). We explored signaling convergence between HDM allergens and TLRs in ROS generation because epithelial cells form the primary barrier against inhaled substances and dictate host responses to allergens and viruses. METHODS: ROS formation by Calu-3 human airway cells was studied by measuring dihydrorhodamine 123 oxidation after activation by polyinosinic:polycytidylic acid (to activate TLR3), CL097 (to activate TLR7), a natural mixture of HDM allergens, or BzATP...
March 15, 2018: Immunity, Inflammation and Disease
https://www.readbyqxmd.com/read/29542268/the-effect-of-oral-immunotherapy-treatment-in-severe-ige-mediated-milk-peanut-and-egg-allergy-in-adults
#8
Jarkko Mäntylä, Tuuli Thomander, Auli Hakulinen, Kaarina Kukkonen, Kati Palosuo, Helena Voutilainen, Anna Pelkonen, Paula Kauppi
INTRODUCTION: The standard care of severe food allergy in both adults and children means avoidance of allergens. In recent years promising results of oral immunotherapy (OIT) have been reported in children. In adults, information on OIT in severe food allergy is very limited. OBJECTIVE: We aimed to study if OIT is possible in adults. METHODS: We report OIT results in 10 adult patients with milk OIT, nine adult patients with peanut OIT, and four adult patients with egg OIT...
March 15, 2018: Immunity, Inflammation and Disease
https://www.readbyqxmd.com/read/29516688/hygiene-practices-are-they-protective-factors-for-eczema-symptoms
#9
David Ferrandiz-Mont, Nur Wahyuniati, Hsin-Jen Chen, Mulyadi Mulyadi, Tjut Mariam Zanaria, Dar-Der Ji
INTRODUCTION: Exact etiology and proper treatment of eczema are still unknown. The hygiene hypothesis and epidermal barrier dysfunction hypothesis attempted to give some plausible explanations for these issues but they still remain unclear. The identification of factors, including hygiene practices, related to eczema symptoms (ES) could shed some light on these matters. Therefore, this study aimed to determine risk factors related to ES and the ES prevalence in two disparate areas in terms of urbanization in Aceh, Indonesia...
March 7, 2018: Immunity, Inflammation and Disease
https://www.readbyqxmd.com/read/29430878/placental-implantation-over-prior-cesarean-scar-causes-activation-of-fetal-regulatory-t-cells
#10
Tina A Nguyen, Daniel A Kahn, Andrea I Loewendorf
INTRODUCTION: Maternal-fetal chimerism is miniscule, a testament to the integrity of the uteroplacental interface. The soundness of this border region is potentially altered through cesarean delivery of prior babies with uncertain consequences for the following pregnancies. METHODS: Using multicolor flow cytometry and quantitative PCR of non-inherited maternal antigens we performed a retrospective case control pilot study and formulated the null hypothesis that placental implantation over a prior uterine scar does not result in the presence of memory Treg (CD45RO+) in the fetus...
February 12, 2018: Immunity, Inflammation and Disease
https://www.readbyqxmd.com/read/29388365/collagen-derived-peptides-modulate-cd4-t-cell-differentiation-and-suppress-allergic-responses-in-mice
#11
Akihiko Nishikimi, Yoh-Ichi Koyama, Sayaka Ishihara, Shusaku Kobayashi, Chisa Tometsuka, Masashi Kusubata, Kumiko Kuwaba, Osamu Hayashida, Shunji Hattori, Koko Katagiri
INTRODUCTION: Collagen peptides have been widely used as a food supplement. After ingestion of collagen peptides, oligopeptides containing hydroxyproline (Hyp), which are known to have some physiological activities, are detected in peripheral blood. However, the effects of collagen-peptide administration on immune response are unclear. In the present study, we tested the effects of collagen-peptide ingestion on allergic response and the effects of collagen-derived oligopeptides on CD4+ T-cell differentiation...
February 1, 2018: Immunity, Inflammation and Disease
https://www.readbyqxmd.com/read/29235261/interferon-%C3%AE-2-and-interferon-%C3%AE-induce-the-degranulation-independent-production-of-vegf-a-and-il-1-receptor-antagonist-and-other-mediators-from-human-mast-cells
#12
Sharon A Oldford, Suzanne P Salsman, Liliana Portales-Cervantes, Raidan Alyazidi, Robert Anderson, Ian D Haidl, Jean S Marshall
BACKGROUND: Mast cells are resident immune effector cells, often studied in the context of allergic disease. Found in substantial numbers at sites of potential infection they are increased at sites of angiogenesis and can be pivotal for the sensing and clearance of a variety of pathogens. Interferons (IFNs) are cytokines that are critical for host defence against intracellular pathogens. Increased levels of IFNs are observed during viral infection and in autoimmune diseases. IFNs are also widely used therapeutically and have been examined in the therapy of severe asthma...
March 2018: Immunity, Inflammation and Disease
https://www.readbyqxmd.com/read/29205929/dendritic-cell-targeted-hiv-1-gag-protein-vaccine-provides-help-to-a-recombinant-newcastle-disease-virus-vectored-vaccine-including-mobilization-of-protective-cd8-t-cells
#13
Loveline N Ngu, Nadesh N Nji, Georgia Ambada, Apeh A Ngoh, Ghislain D Njambe Priso, Jules C Tchadji, Abel Lissom, Suzanne H Magagoum, Carol N Sake, Thibau F Tchouangueu, George O Chukwuma, Arinze S Okoli, Bertrand Sagnia, Rebecca Chukwuanukwu, Denis M Tebit, Charles O Esimone, Alain B Waffo, Chae G Park, Klaus Überla, Godwin W Nchinda
INTRODUCTION: Recombinant Newcastle Disease virus (rNDV) vectored vaccines are safe mucosal applicable vaccines with intrinsic immune-modulatory properties for the induction of efficient immunity. Like all viral vectored vaccines repeated inoculation via mucosal routes invariably results to immunity against viral vaccine vectors. To obviate immunity against viral vaccine vectors and improve the ability of rNDV vectored vaccines in inducing T cell immunity in murine air way we have directed dendritic cell targeted HIV-1 gag protein (DEC-Gag) vaccine; for the induction of helper CD4+ T cells to a Recombinant Newcastle disease virus expressing codon optimized HIV-1 Gag P55 (rNDV-L-Gag) vaccine...
March 2018: Immunity, Inflammation and Disease
https://www.readbyqxmd.com/read/29168324/environmental-levels-of-avian-antigen-are-relevant-to-the-progression-of-chronic-hypersensitivity-pneumonitis-during-antigen-avoidance
#14
Manabu Sema, Yasunari Miyazaki, Toshiharu Tsutsui, Makoto Tomita, Yoshinobu Eishi, Naohiko Inase
BACKGROUND: In chronic hypersensitivity pneumonitis (chronic HP), antigen avoidance is critical for disease management; however, complete avoidance is difficult because of unrecognized exposure to antigens. Recently, we revealed that the amount of avian antigen (AAA) in household dust at the time of diagnosis predicted the progression of chronic bird-related HP. The purpose of this study is to evaluate the relationship between the prognosis of chronic bird-related HP and the AAA that remained in the environment during antigen avoidance...
March 2018: Immunity, Inflammation and Disease
https://www.readbyqxmd.com/read/28952190/il-12-and-il-15-induce-the-expression-of-cxcr6-and-cd49a-on-peripheral-natural-killer-cells
#15
Theresa Hydes, Angela Noll, Gabriela Salinas-Riester, Mohammed Abuhilal, Thomas Armstrong, Zaed Hamady, John Primrose, Arjun Takhar, Lutz Walter, Salim I Khakoo
INTRODUCTION: Murine hepatic NK cells exhibit adaptive features, with liver-specific adhesion molecules CXCR6 and CD49a acting as surface markers. METHODS: We investigated human liver-resident CXCR6+ and CD49a+ NK cells using RNA sequencing, flow cytometry, and functional analysis. We further assessed the role of cytokines in generating NK cells with these phenotypes from the peripheral blood. RESULTS: Hepatic CD49a+ NK cells could be induced using cytokines and produce high quantities of IFNγ and TNFα, in contrast to hepatic CXCR6+ NK cells...
March 2018: Immunity, Inflammation and Disease
https://www.readbyqxmd.com/read/29314730/transcription-factors-early-growth-response-gene-egr-2-and-3-control-inflammatory-responses-of-tolerant-t-cells
#16
Becky Omodho, Tizong Miao, Alistair L J Symonds, Randeep Singh, Suling Li, Ping Wang
INTRODUCTION: Impaired proliferation and production of IL2 are the hallmarks of experimental T cell tolerance. However, in most autoimmune diseases, auto-reactive T cells do not display hyper proliferation, but inflammatory phenotypes. METHODS: We have now demonstrated that the transcription factors Egr2 and 3 are important for the control of inflammatory cytokine production by tolerant T cells, but not for tolerance induction. RESULTS: In the absence of Egr2 and 3, T cell tolerance, as measured by impaired proliferation and production of IL2, can still be induced, but tolerant T cells produced high levels of inflammatory cytokines...
January 3, 2018: Immunity, Inflammation and Disease
https://www.readbyqxmd.com/read/29314720/correlation-of-april-with-production-of-inflammatory-cytokines-during-acute-malaria-in-the-brazilian-amazon
#17
Raquel A Pinna, Adriana C Dos Santos, Daiana S Perce-da-Silva, Luciene A da Silva, Rodrigo N Rodrigues da Silva, Marcelo R Alves, Fátima Santos, Joseli de Oliveira Ferreira, Josué C Lima-Junior, Déa M Villa-Verde, Paula M De Luca, Carla E Carvalho-Pinto, Dalma M Banic
INTRODUCTION: A proliferation-inducing ligand (APRIL) and B cell activation factor (BAFF) are known to play a significant role in the pathogenesis of several diseases, including BAFF in malaria. The aim of this study was to investigate whether APRIL and BAFF plasma concentrations could be part of inflammatory responses associated with P. vivax and P. falciparum malaria in patients from the Brazilian Amazon. METHODS: Blood samples were obtained from P. vivax and P...
January 3, 2018: Immunity, Inflammation and Disease
https://www.readbyqxmd.com/read/29282904/human-t-cell-responses-to-dengue-and-zika-virus-infection-compared-to-dengue-zika-coinfection
#18
Jessica Badolato-Corrêa, Juan Camilo Sánchez-Arcila, Thiara Manuele Alves de Souza, Luciana Santos Barbosa, Priscila Conrado Guerra Nunes, Monique da Rocha Queiroz Lima, Mariana Gandini, Ana Maria Bispo de Filippis, Rivaldo Venâncio da Cunha, Elzinandes Leal de Azeredo, Luzia Maria de-Oliveira-Pinto
INTRODUCTION: Zika virus (ZIKV) and dengue virus (DENV) co-circulated during latest outbreaks in Brazil, hence, it is important to evaluate the host cross-reactive immune responses to these viruses. So far, little is known about human T cell responses to ZIKV and no reports detail adaptive immune responses during DENV/ZIKV coinfection. METHODS: Here, we studied T cells responses in well-characterized groups of DENV, ZIKV, or DENV/ZIKV infected patients and DENV-exposed healthy donors...
December 28, 2017: Immunity, Inflammation and Disease
https://www.readbyqxmd.com/read/29265735/preclinical-safety-and-immunological-efficacy-of-alternaria-alternata-polymerized-extracts
#19
María Morales, María T Gallego, Victor Iraola, Raquel Moya, Soraya Santana, Jerónimo Carnés
INTRODUCTION: Alternaria alternata is a widespread fungi whose allergy is a risk factor for asthma development. The use of a polymerized allergen extract (allergoid) may be safer than native extract based treatments while maintaining efficacy. The objective of this study was to characterize biochemically and immunochemically a new Alternaria alternata allergoid. METHODS: Characterization of native and allergoid extracts was performed by determination of protein content, protein and allergenic profile, biological potency, identification of Alternaria allergens, and Alt a 1 quantification...
December 19, 2017: Immunity, Inflammation and Disease
https://www.readbyqxmd.com/read/29148621/guidelines-for-the-use-of-flow-cytometry
#20
EDITORIAL
Marc Veldhoen
No abstract text is available yet for this article.
December 2017: Immunity, Inflammation and Disease
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