Valentino Collini, Alessandro Andreis, Marzia De Biasio, Maria De Martino, Miriam Isola, Nicole Croatto, Veronica Lepre, Luca Cantarini, Marco Merlo, Gianfranco Sinagra, Antonio Abbate, George Lazaros, Antonio Brucato, Allan L Klein, Massimo Imazio
AIM: Anakinra, an anti IL-1 agent targeting IL-1 alfa and beta, is available for the treatment of recurrent pericarditis in cases with corticosteroid dependence and colchicine resistance after failure of conventional therapies. However, it is unclear if the combination with colchicine, a non-specific inhibitor of the inflammasome targeting the same inflammatory pathway of IL-1, could provide additional benefit to prevent further recurrences. The aim of the present observational study is to assess whether the addition of colchicine on top of anakinra could prolong the time to first recurrence and prevent recurrences better than anakinra alone...
March 15, 2024: Open Heart