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Open Heart

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https://www.readbyqxmd.com/read/29018536/efficacy-and-safety-of-non-vitamin-k-antagonist-oral-anticoagulants-compared-with-warfarin-in-patients-with-atrial-fibrillation
#1
Leif Friberg, Jonas Oldgren
AIMS: Non-vitamin K antagonist oral anticoagulants (NOACs) were in pivotal randomised controlled trials at least non-inferior to warfarin for stroke prevention in atrial fibrillation, but time in therapeutic range (TTR) for warfarin was lower (mean 55%-65%) than in Swedish general care where TTR is >70%. We compared efficacy and safety of NOACs and warfarin treatment for stroke prevention in Sweden. METHODS: Retrospective cohort study of all non-selected oral anticoagulation naïve atrial fibrillation patients with first prescription for NOACs or warfarin between December 2011 and December 2014, excluding patients with mitral stenosis or mechanical valvular prosthesis...
2017: Open Heart
https://www.readbyqxmd.com/read/29018535/left-ventricular-longitudinal-systolic-function-analysed-by-2d-speckle-tracking-echocardiography-in-heart-failure-with-preserved-ejection-fraction-a-meta-analysis
#2
Daniel Armando Morris, Xin-Xin Ma, Evgeny Belyavskiy, Radhakrishnan Aravind Kumar, Martin Kropf, Robin Kraft, Athanasios Frydas, Engin Osmanoglou, Esteban Marquez, Erwan Donal, Frank Edelmann, Carsten Tschöpe, Burkert Pieske, Elisabeth Pieske-Kraigher
BACKGROUND: The purpose of this meta-analysis was to confirm if the global longitudinal systolic function of the left ventricle (LV) is altered in patients with heart failure with preserved ejection fraction (HFpEF). METHODS: We searched in different databases (Medline, Embase and Cochrane) studies that analysed LV global longitudinal systolic strain (GLS) in patients with HFpEF and in controls (such as healthy subjects or asymptomatic patients with arterial hypertension, diabetes mellitus or coronary artery disease)...
2017: Open Heart
https://www.readbyqxmd.com/read/28912956/cardiometabolic-effects-of-a-novel-sirt1-activator-srt2104-in-people-with-type-2-diabetes-mellitus
#3
Radzi M Noh, Sowmya Venkatasubramanian, Shruti Daga, Jeremy Langrish, Nicholas L Mills, Ninian N Lang, Ethan Hoffmann, Brian Waterhouse, David E Newby, Brian M Frier
BACKGROUND: The cardiometabolic effects of SRT2104, a novel SIRT1 activator, were investigated in people with type 2 diabetes mellitus (T2DM). METHODS: Fifteen adults with T2DM underwent a randomised, double-blind, placebo-controlled cross-over trial and received 28 days of oral SRT2104 (2.0 g/day) or placebo. Forearm vasodilatation (measured during intrabrachial bradykinin, acetylcholine and sodium nitroprusside infusions) as well as markers of glycaemic control, lipid profile, plasma fibrinolytic factors, and markers of platelet-monocyte activation, were measured at baseline and at the end of each treatment period...
2017: Open Heart
https://www.readbyqxmd.com/read/28912955/targeting-aspirin-resistance-with-nutraceuticals-a-possible-strategy-for-reducing-cardiovascular-morbidity-and-mortality
#4
EDITORIAL
James J DiNicolantonio, James H O'Keefe, Mark F McCarty
No abstract text is available yet for this article.
2017: Open Heart
https://www.readbyqxmd.com/read/28890793/call-for-joint-informed-consent-in-athletes-with-inherited-cardiac-conditions
#5
REVIEW
Rui Providencia, Carina Teixeira, Oliver R Segal, Augustus Ullstein, Pier D Lambiase
Informed consent is of the utmost importance, especially in complex clinical situations where patients may be exposed to a life-threatening risk. A particularly complex example is the eligibility of competitive athletes with inherited cardiac conditions on medical grounds, especially when the risk is low or unquantifiable. The rationale and benefits of a joint informed consent for athletes to compete with potentially life-threatening cardiac conditions are discussed in this manuscript.
2017: Open Heart
https://www.readbyqxmd.com/read/28890792/multicentre-analysis-of-current-st-elevation-myocardial-infarction-acute-care-pathways
#6
Joppe Tra, Carolien de Blok, Ineke van der Wulp, Martine C de Bruijne, Cordula Wagner
BACKGROUND: Rapid reperfusion with percutaneous coronary intervention (PCI) is vital for patients with ST segment elevation myocardial infarction (STEMI). However, the guideline-recommended time targets are regularly exceeded. The goal of this study was to gain insight into how Dutch PCI centres try to achieve these time targets by comparing their care processes with one another and with the European guideline-recommended process. In addition, accelerating factors perceived by care providers were identified...
2017: Open Heart
https://www.readbyqxmd.com/read/28878953/extracellular-cardiac-matrix-biomarkers-in-patients-with-reduced-ejection-fraction-heart-failure-as-predictors-of-response-to-cardiac-resynchronisation-therapy-a-systematic-review
#7
REVIEW
Christopher J McAloon, Danish Ali, Thomas Hamborg, Prithwish Banerjee, Paul O'Hare, Harpal Randeva, Faizel Osman
OBJECTIVE: Cardiac resynchronisation therapy (CRT) is an effective therapy for selected patients with heart failure (HF); however, a significant non-response rate exists. We examined current evidence on extracellular cardiac matrix (ECM) biomarkers in predicting response following CRT. METHODS: Complete literature review of PubMed, Ovid SP MEDLINE, Cochrane Library and TRIP, reference lists, international cardiology conferences and ongoing studies between December 1999 and December 2015 conducted according to prospectively registered study selection and analysis criteria (PROSPERO:CRD42016025864) was performed...
2017: Open Heart
https://www.readbyqxmd.com/read/28878952/pathophysiology-of-exercise-intolerance-in-chronic-diseases-the-role-of-diminished-cardiac-performance-in-mitochondrial-and-heart-failure-patients
#8
Jodi McCoy, Matthew Bates, Christopher Eggett, Mario Siervo, Sophie Cassidy, Jane Newman, Sarah A Moore, Grainne Gorman, Michael I Trenell, Lazar Velicki, Petar M Seferovic, John G F Cleland, Guy A MacGowan, Doug M Turnbull, Djordje G Jakovljevic
OBJECTIVE: Exercise intolerance is a clinical hallmark of chronic conditions. The present study determined pathophysiological mechanisms of exercise intolerance in cardiovascular, neuromuscular, and metabolic disorders. METHODS: In a prospective cross-sectional observational study 152 patients (heart failure reduced ejection fraction, n=32; stroke, n=34; mitochondrial disease, n=28; type two diabetes, n=28; and healthy controls, n=30) performed cardiopulmonary exercise testing with metabolic and haemodynamic measurements...
2017: Open Heart
https://www.readbyqxmd.com/read/28878951/high-pitch-versus-conventional-cardiovascular-ct-in-patients-being-assessed-for-transcatheter-aortic-valve-implantation-a-real-world-appraisal
#9
Tevfik F Ismail, Emma Cheasty, Laurence King, Sahar Naaseri, Olga Lazoura, Natalie Gartland, Simon Padley, Michael B Rubens, Isabel Castellano, Edward D Nicol
OBJECTIVE: High-pitch protocols are increasingly used in cardiovascular CT assessment for transcatheter aortic valve implantation (TAVI), but the impact on diagnostic image quality is not known. METHODS: We reviewed 95 consecutive TAVI studies: 44 (46%) high-pitch and 51 (54%) standard-pitch. Single high-pitch scans were performed regardless of heart rate. For standard-pitch acquisitions, a separate CT-aortogram and CT-coronary angiogram were performed with prospective gating, unless heart rate was ≥70 beats/min, when retrospective gating was used...
2017: Open Heart
https://www.readbyqxmd.com/read/28878950/exercise-dose-and-all-cause-mortality-within-extended-cardiac-rehabilitation-a-cohort-study
#10
Claire Taylor, Costas Tsakirides, James Moxon, James W Moxon, Michael Dudfield, Klaus Witte, Lee Ingle, Sean Carroll
AIMS: To investigate the relationship between exercise participation, exercise 'dose' expressed as metabolic equivalent (MET) hours (h) per week, and prognosis in individuals attending an extended, community-based exercise rehabilitation programme. METHODS: Cohort study of 435 participants undertaking exercise-based cardiac rehabilitation (CR) in Leeds, West Yorkshire, UK between 1994 and 2006, followed up to 1 November 2013. MET intensity of supervised exercise was estimated utilising serial submaximal exercise test results and corresponding exercise prescriptions...
2017: Open Heart
https://www.readbyqxmd.com/read/28878949/association-of-life-s-simple-7-and-presence-of-cardiovascular-disease-in-general-australians
#11
Yang Peng, Zhiqiang Wang
OBJECTIVE: The American Heart Association developed Life's Simple 7 to define and monitor cardiovascular health (CVH), but their contributions to cardiovascular disease (CVD) in general Australians are still unclear. Our study aimed to evaluate the separate and combined effects of Life's Simple 7 on CVD among Australians. METHODS: We performed a cross-sectional study based on 7499 adults (≥18 years) who have been tested for total cholesterol and fasting plasma glucose as part of the 2011-2012 Australian Health Survey...
2017: Open Heart
https://www.readbyqxmd.com/read/28878948/the-impact-of-passive-and-active-smoking-on-inflammation-lipid-profile-and-the-risk-of-myocardial-infarction
#12
Ritienne Attard, Philip Dingli, Carine J M Doggen, Karen Cassar, Rosienne Farrugia, Stephanie Bezzina Wettinger
OBJECTIVE: To investigate the effect of passive smoking, active smoking and smoking cessation on inflammation, lipid profile and the risk of myocardial infarction (MI). METHODS: A total of 423 cases with a first MI and 465 population controls from the Maltese Acute Myocardial Infarction (MAMI) Study were analysed. Data were collected through an interviewer-led questionnaire, and morning fasting blood samples were obtained. ORs adjusted for the conventional risk factors of MI (aORs) were calculated as an estimate of the relative risk of MI...
2017: Open Heart
https://www.readbyqxmd.com/read/28878947/the-importance-of-early-life-family-factors-in-the-association-between-cardiovascular-risk-factors-and-early-cardiovascular-mortality
#13
Marte K R Kjøllesdal, Inger Ariansen, Laust H Mortensen, Øyvind Næss
OBJECTIVE: To explore the importance of early life factors shared by siblings, such as parental socioeconomic position, parental practices, housing and neighbourhood, for the association between cardiovascular disease (CVD) risk factors and mortality from CVD, ischaemic heart disease (IHD) and cerebrovascular disease. METHODS: Norwegian health surveys (1974-2003) were linked with data from the Norwegian Family Based Life Course Study and the Cause of Death Registry...
2017: Open Heart
https://www.readbyqxmd.com/read/28878946/supplemental-n-acetylcysteine-and-other-measures-that-boost-intracellular-glutathione-can-downregulate-interleukin-1%C3%AE-signalling-a-potential-strategy-for-preventing-cardiovascular-events
#14
EDITORIAL
https://www.readbyqxmd.com/read/28878945/gated-metabolic-myocardial-imaging-a-surrogate-for-dual-perfusion-metabolism-imaging-by-positron-emission-tomography
#15
Abdallah AlMohammad, Murdoch Y Norton, Andrew E Welch, Peter F Sharp, Stephen Walton
OBJECTIVE: Perfusion-metabolism mismatch pattern on positron emission tomography (PET) predicts hibernating myocardium. We assess the ECG-gated metabolic PET as a surrogate for the perfusion-metabolism mismatch pattern on PET imaging. METHODS: (13)N-Ammonia (NH3) and (18)F-fluorodeoxyglucose (FDG) are respectively perfusion and metabolism PET tracers. We used ECG gating to acquire FDG-PET to collect wall thickening (mechanical) data. These allow detection of metabolic activity in regions with reduced contraction (metabolism-mechanical mismatch pattern)...
2017: Open Heart
https://www.readbyqxmd.com/read/28878944/development-and-validation-of-a-clinical-risk-score-to-predict-mortality-after-percutaneous-coronary-intervention
#16
Joshua J S Wall, Javaid Iqbal, Michael Andrews, Dawn Teare, Mina Ghobrial, Thomas Hinton, Samuel Turton, Leila Quffa, Magdi El-Omar, Douglas G Fraser, Anjan Siotia, Julian Gunn
OBJECTIVE: To develop and validate a contemporary clinical risk score to predict mortality after percutaneous coronary intervention (PCI). METHODS: Using data collected from patients undergoing PCI at the South Yorkshire Cardiothoracic Centre, Sheffield, UK, between January 2007 and September 2013, a risk score was developed to predict mortality. Logistic regression was used to evaluate the effect of each variable upon 30-day mortality. A backwards stepwise logistic regression model was then used to build a predictive model...
2017: Open Heart
https://www.readbyqxmd.com/read/28861274/long-term-left-ventricular-remodelling-after-revascularisation-for-st-segment-elevation-myocardial-infarction-as-assessed-by-cardiac-magnetic-resonance-imaging
#17
Mariella Ecj Hassell, Wieneke Vlastra, Lourens Robbers, Alexander Hirsch, Robin Nijveldt, Jan Gp Tijssen, Albert C van Rossum, Felix Zijlstra, Jan J Piek, Ronak Delewi
OBJECTIVE: Left ventricular remodelling following a ST-segment elevated myocardial infarction (STEMI) is an adaptive response to maintain the cardiac output despite myocardial tissue loss. Limited studies have evaluated long term ventricular function using cardiac magnetic resonance imaging (CMR) after STEMI. METHODS: Study population consisted of 155 primary percutaneous coronary intervention treated first STEMI patients. CMR was performed at 4±2 days, 4 months and 24 months follow-up...
2017: Open Heart
https://www.readbyqxmd.com/read/28766585/the-relevance-of-periprocedural-troponin-rise-the-never-ending-story
#18
EDITORIAL
Georg Marcus Fröhlich, David Manuel Leistner
No abstract text is available yet for this article.
2017: Open Heart
https://www.readbyqxmd.com/read/28761685/two-year-clinical-outcomes-of-patients-treated-with-the-dual-therapy-stent-in-a-1000-patient-all-comers-registry
#19
Deborah N Kalkman, Pier Woudstra, Ian B A Menown, Peter den Heijer, Arnoud Wj Van't Hof, Andrejs Erglis, Harry Suryapranata, Karin E Arkenbout, Andrés Iñiguez, Philippe Muller, Jan G Tijssen, Marcel A M Beijk, Robbert J de Winter
OBJECTIVE: The dual-therapy stent combines an abluminal biodegradable drug-eluting coating, with a 'pro-healing' luminal layer. This bioengineered layer attracts circulating endothelial progenitor cells that can differentiate into normal endothelium. Rapid endothelialisation of the stent might allow safe short dual antiplatelet therapy. We aim to assess clinical outcomes in patients treated with this novel device at 2-year follow-up. METHODS: A total of 1000 patients were included in the REMEDEE Registry to evaluate clinical outcomes after treatment with the dual-therapy stent...
2017: Open Heart
https://www.readbyqxmd.com/read/28761684/osteopontin-predicts-clinical-outcome-in-patients-after-treatment-of-severe-aortic-stenosis-with-transcatheter-aortic-valve-implantation-tavi
#20
Matthias Lutz, Nora von Ingersleben, Moritz Lambers, Mark Rosenberg, Sandra Freitag-Wolf, Astrid Dempfle, Georg Lutter, Johanne Frank, Peter Bramlage, Norbert Frey, Derk Frank
OBJECTIVE: Osteopontin (OPN) is an extracellular matrix protein that plays an integral role in myocardial remodelling and has previously been shown to be a valuable biomarker in cardiovascular disease. Because of the concentric myocardial hypertrophy associated with severe, symptomatic aortic stenosis (AS), we hypothesised that OPN expression may have a prognostic value in patients undergoing transcatheter aortic valve implantation (TAVI). METHODS: We prospectively included 217 patients undergoing TAVI between February 2011 and December 2013 with a median follow-up of 349 days...
2017: Open Heart
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