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Open Heart

Nevena Zivkovic, Gabby Elbaz-Greener, Feng Qiu, Yaron Arbel, Asim N Cheema, Danny Dvir, Paul Fefer, Ariel Finkelstein, Stephen E Fremes, Sam Radhakrishnan, Josep Rodés-Cabau, Mony Shuvy, Harindra C Wijeysundera
Background: Acute kidney injury (AKI) is a common post-transcatheter aortic valve replacement (TAVR) complication associated with a poor prognosis. We sought to create a risk calculator using information that would be available during the work-up period. Methods: Data were obtained from a multicentre TAVR registry (n=1993) with cases from 1 January 2012 to 31 December 2015. We used logistic regression to create a risk calculator to predict AKI as defined by the Valve Academic Research Consortium Guidelines...
2018: Open Heart
Gijs E De Maat, Bart Mulder, Wouter L Berretty, Meelad I H Al-Jazairi, Yong E S Tan, Ans C P Wiesfeld, Massimo A Mariani, Isabelle C Van Gelder, Michiel Rienstra, Yuri Blaauw
Aims: Obesity is an increasing health problem and is an important risk factor for the development of atrial fibrillation (AF). We investigated the association of body mass index (BMI) on the safety and long-term efficacy of pulmonary vein isolation (PVI) for drug-refractory AF. Methods: 414 consecutive patients who underwent transcatheter PVI for AF between 2003 and 2013 were included. Successful PVI was defined as absence of atrial arrhythmia on Holter monitoring or ECG, without and with antiarrhythmic drugs during follow-up...
2018: Open Heart
Keitaro Akita, Hikaru Tsuruta, Shinsuke Yuasa, Mitsushige Murata, Keiichi Fukuda, Yuichiro Maekawa
Objectives: To evaluate whether repeated brain natriuretic peptide (BNP) measurements after percutaneous transluminal septal myocardial ablation (PTSMA) provide prognostic information regarding the response to PTSMA in patients with drug-refractory hypertrophic obstructive cardiomyopathy (HOCM). Background: Plasma BNP levels are associated with clinical outcomes in patients with HOCM. However, the prognostic value of plasma BNP level changes before and after PTSMA remains unclear...
2018: Open Heart
Pierre Deharo, Thomas W Johnson, Hazim Rahbi, Raveen Kandan, Ruth Bowles, Abdul Mozid, Stephen Dorman, Julian W Strange, Andreas Baumbach
Background: The evidence for benefits of bivalirudin over heparin has recently been challenged. We aimed to analyse the safety and cost-effectiveness following reintroduction of heparin instead of bivalirudin as the standard anticoagulation for primary percutaneous coronary intervention (PPCI) in a high-volume centre. Methods and results: This analysis was an open-label, prospective registry including all patients admitted to our centre for PPCI from April 2014 to April 2016...
2018: Open Heart
(no author information available yet)
[This corrects the article DOI: 10.1136/openhrt-2016-000521.][This corrects the article DOI: 10.1136/openhrt-2016-000521.].
2018: Open Heart
Robert Clarke, Elsa Valdes-Marquez, Michael Hill, Joanne Gordon, Martin Farrall, Anders Hamsten, Hugh Watkins, Jemma C Hopewell
Objective: The aims of the study were to examine the associations of plasma levels of five cytokines (interleukin (IL)-6, IL-5, interferon-gamma (IFN-γ), tumour necrosis factor-alpha (TNF-α) and IL-6 receptor (IL-6R)) and C reactive protein (CRP) with risk of coronary heart disease (CHD). Methods: In a case-control study of 931 CHD cases and 974 controls, logistic regression was used to estimate the OR and 95% CI of CHD for extreme thirds of biomarkers after adjustment for established risk factors...
2018: Open Heart
A John Camm, Keith A A Fox
Randomised controlled trials (RCTs) provide the reference standard for comparing the efficacy of one therapy or intervention with another. However, RCTs have restrictive inclusion and exclusion criteria; thus, they are not fully representative of an unselected real-world population. Real-world evidence (RWE) studies encompass a wide range of research methodologies and data sources and can be broadly categorised as non-interventional studies, patient registries, claims database studies, patient surveys and electronic health record studies...
2018: Open Heart
Alexander Barth, Seyrani Yücel, Hüseyin Ince, Gabriele Doblhammer
Background: Transcatheter aortic valve implantation (TAVI) is a minimally invasive treatment for aortic valve patients who are inoperable or have a prohibitively high surgical risk for surgical aortic valve replacement (SAVR). Most studies compare the efficacy of TAVI and SAVR, yet the assessment of TAVI for this group of patients requires more study. Methods: This quasiexperimental study compares TAVI cases (ages of 75-90 years, n=187) ex-post with a control group without implantation (n=728, 4:1 ratio intended)...
2018: Open Heart
Moritz Biener, Evangelos Giannitsis, Manuel Kuhner, Thomas Zelniker, Matthias Mueller-Hennessen, Mehrshad Vafaie, Kiril M Stoyanov, Franz-Josef Neumann, Hugo A Katus, Willibald Hochholzer, Christian Marc Valina
Objective: To evaluate the prognostic performance of high-sensitivity cardiac troponin T (hs-cTnT) compared with the ESC-SCORE. Methods: We included low-risk outpatients with stable cardiovascular (CV) disease categorised into need for non-secondary and secondary prevention. The prognostication of hs-cTnT at index visit was compared with the European Society of Cardiology-Systematic COronary Risk Evaluation (ESC-SCORE) with respect to all-cause mortality (ACM) and two composite endpoints (ACM, acute myocardial infarction (AMI) and stroke and ACM, AMI, stroke and rehospitalisation for acute coronary syndrome (ACS) and decompensated heart failure (DHF))...
2018: Open Heart
Sung Il Im, Jinho Heo, Bong Joon Kim, Kyoung-Im Cho, Hyun Su Kim, Jung Ho Heo, Jin Yong Hwang
Objectives: Relationship between atrial fibrillation (AF) and inflammation was shown in previous studies. However, there was limited data about the association between the periodontitis and AF in the long-term follow-up. The aim of this study was to evaluate the impact of periodontitis on long-term clinical outcomes in patients with AF. Methods: The Kosin University echocardiography, ECG and periodontitis database were reviewed from 2013 to 2015 to identify patients with AF...
2018: Open Heart
James J DiNicolantonio, Mark F McCarty
No abstract text is available yet for this article.
2018: Open Heart
Walid Ben Ali, Pierre Voisine, Peter Skov Olsen, Hugues Jeanmart, Nicolas Noiseux, Tracy Goeken, Vilas Satishchandran, Filippo Cademartiri, Garry Cutter, Dave Veerasingam, Craig Brown, Maximilian Y Emmert, Louis P Perrault
Introduction: Saphenous vein grafts (SVGs) remain the most often used conduits in coronary artery bypass grafting (CABG). However, they are prone to vein graft disease (VGD) during follow-up, which may compromise clinical outcomes. Injury to the SVG endothelium during harvesting and storage promotes neointimal hyperplasia that can advance to atherosclerosis characterised by SVG failure. This trial investigates the potential benefit of DuraGraft, a novel, one-time intraoperative graft treatment developed to efficiently protect the structural and functional integrity of the vascular endothelium, on the development and progression of VGD in CABG patients...
2018: Open Heart
(no author information available yet)
[This corrects the article DOI: 10.1136/openhrt-2017-000668.][This corrects the article DOI: 10.1136/openhrt-2017-000668.].
2018: Open Heart
(no author information available yet)
[This corrects the article DOI: 10.1136/openhrt-2017-000672.][This corrects the article DOI: 10.1136/openhrt-2017-000672.].
2018: Open Heart
Nils Perrin, Tilman Perrin, Anne-Lise Hachulla, Angela Frei, Hajo Müller, Marco Roffi, Mustafa Cikirikcioglu, Christoph Ellenberger, Marc-Joseph Licker, Haran Burri, Stephane Noble
Aim: We compared early postprocedural and midterm evolution of atrioventricular and intraventricular conduction disorders following implantation of the new generation Evolut R (ER) prosthesis in comparison with the previous generation CoreValve (CV) system using routinely recorded ECG up to 6-month follow-up. Methods: All consecutive patients treated by transcathether aortic valve implantation (TAVI) using the Medtronic self-expanding devices for symptomatic severe aortic stenosis in a single centre between October 2011 and February 2016 were considered for inclusion...
2018: Open Heart
Paul Michael Galdas, Alexander Stephen Harrison, Patrick Doherty
Objective: To determine whether there are gender differences in the factors that predict attendance at the initial cardiac rehabilitation baseline assessment (CR engagement) after referral. Methods: Using data from the National Audit of Cardiac Rehabilitation, we analysed data on 95 638 patients referred to CR following a cardiovascular diagnosis/treatment between 2013 and 2016. Eighteen factors that have been shown in previous research to be important predictors of CR participation were investigated and grouped into four categories: sociodemographic factors, cardiac risk factors, patient medical status and service-level factors...
2018: Open Heart
Khaled Alfakih, Jonathan Byrne, Mark Monaghan
The UK National Institute for Health and Care Excellence (NICE) have just updated their guideline on new-onset stable chest pain, recommending that all patients should be investigated with a CT coronary angiography (CTCA). In a separate guideline, NICE recommended CT fractional flow reserve (CT-FFR), to assess coronary stenoses, found on CTCA, stating that this would reduce the need for invasive coronary angiography and hence reduce cost. We discuss the evidence base for CT-FFR and emphasise that we already have established functional imaging tests, with extensive evidence base for efficacy and prognosis and that CT-FFR should be compared with this standard of care and not with the much more expensive and invasive fractional flow reserve undertaken during invasive coronary angiography...
2018: Open Heart
Henrik Hultkvist, Jonas Holm, Rolf Svedjeholm, Farkas Vánky
Objectives: To describe the dynamics of N-terminal pro-B-type natriuretic peptide (NT-proBNP) from preoperative evaluation to 6-month follow-up in patients undergoing aortic valve intervention, and to evaluate NT-proBNP with regard to 1-year mortality. Methods: At preoperative evaluation, we prospectively included 462 patients accepted for aortic valve intervention. The median time to surgical aortic valve replacement (SAVR; n=336) or transcatheter aortic valve implantation (TAVI; n=126) was 4 months...
2018: Open Heart
Jingwen Jessica Chen, Kathryn Gamble, Lisa Graham-Wisener, Kieran McGlade, Jennifer Doherty, Patrick Donnelly, Carol A Stone
Objective: To assess the adequacy of community-based services available in Northern Ireland (NI) and to meet the multidimensional needs of patients living with New York Heart Association Stage III and IV heart failure (HF), as experienced and perceived by general practitioners (GP). Methods: Semistructured interviews were conducted with GPs recruited via the University Department of General Practice and Northern Ireland Medical and Dental Agency. Interviews were transcribed, independently coded and analysed using a six-step thematic analysis approach...
2018: Open Heart
Juan Carlos Kaski, Steffen Gloekler, Roberto Ferrari, Kim Fox, Bernard I Lévy, Michel Komajda, Panos Vardas, Paolo G Camici
In chronic stable angina, elevated heart rate contributes to the development of symptoms and signs of myocardial ischaemia by increasing myocardial oxygen demand and reducing diastolic perfusion time. Accordingly, heart rate reduction is a well-known strategy for improving both symptoms of myocardial ischaemia and quality of life (QOL). The heart rate-reducing agent ivabradine, a direct and selective inhibitor of the I f current, decreases myocardial oxygen consumption while increasing diastolic time, without affecting myocardial contractility or coronary vasomotor tone...
2018: Open Heart
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