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Sexual Medicine

George Lee, Chris G McMahon, Marita McCabe, Hui Jiang, Sung Won Lee, Peter Lim, Bang-Ping Jiann
INTRODUCTION: Premature ejaculation (PE) is one of the most prevalent yet under-reported sexual disorders. Differing sociocultural norms across the Asia-Pacific region provide unique challenges in PE management. METHODS: This web-based study collected data from 5,038 men and women across 11 countries in the Asia-Pacific region. Respondents were recruited from an existing database. MAIN OUTCOME MEASURES: The initiators and barriers for PE discussions and for seeking professional management following self-treatment, as well as their choices and expectations of healthcare professionals (HCPs)...
December 2016: Sexual Medicine
Katherine LePage, Amanda Selk
INTRODUCTION: Vulvodynia is a chronic pain disorder that negatively impacts the quality of life of affected women. AIM: The goal of this study was to identify unmet needs among localized provoked vulvodynia patients. METHODS: A qualitative needs assessment was performed in a subspecialized vulvar clinic in a single academic institution in Canada. Semistructured interviews were conducted, recorded, and analyzed using the constant comparative method of grounded theory to identify common themes...
December 2016: Sexual Medicine
Saturnino Luján, Ramón Rogel, Enrique Broseta, Francisco Boronat
INTRODUCTION: Penile prosthesis (PP) is the established treatment for patients with erectile dysfunction (ED) who do not respond to phosphodiesterase inhibitors and intracavernosal injections. In general, these devices have been largely successful but there are not free of serious complication such as PP infection (PPI). PPI requires immediate surgical removal or salvage rescue of the PP. AIM: In this report, we present two clinical cases with inflatable PP (IPP) treated locally with antibiotic and high pressure irrigation and then avoid the PP removal or salvage rescue...
December 2016: Sexual Medicine
Hyun-Suk Lee, Sun-Ouck Kim, Kyuyoun Ahn, Kwangsung Park
INTRODUCTION: Water channel aquaporin 3 (AQP3) is an aquaglyceroporin that transports small neutral solutes and water. All-trans retinoic acid (ATRA), a member of the retinoid drug class, acts as a regulator in several biological processes. AIM: To investigate the effect of ATRA on the expression of AQP3 in human vaginal epithelial cells. METHODS: Human vaginal mucosal epithelial cells (CRL2616) were treated with ATRA 0, 0.01, 0.1, and 1 μmol/L for 24 hours to examine the dose-dependent effects of ATRA and with ATRA 1 μmol/L for 0, 3, 6, 12, and 24 hours...
December 2016: Sexual Medicine
Amado Bechara, Adolfo Casabé, Walter De Bonis, Pablo Gomez Ciciclia
INTRODUCTION: Low-intensity shockwave therapy (LISWT) has recently emerged as a promising method in the treatment of erectile dysfunction (ED). AIM: To assess the long-term results of the effectiveness and safety of LISWT in patients with ED who are non-responders to phosphodiesterase type 5 inhibitor (PDE5i) treatment. METHODS: This open-label, longitudinal, and observational study investigated an uncontrolled population of 50 consecutive patients whose ED was unresponsive to PDE5i treatment...
December 2016: Sexual Medicine
Amr Abdelhamed, Shin-Ichi Hisasue, Essam A Nada, Ali M Kassem, Mohammed Abdel-Kareem, Shigeo Horie
INTRODUCTION: Erectile dysfunction (ED) can precede coronary artery disease. In addition, silent myocardial ischemia (SMI) is more common in diabetic patients and is a strong predictor of cardiac events and death. AIM: To evaluate the presence of SMI in patients with diabetes and ED using multidetector computed tomographic coronary angiography (MDCT-CA). METHODS: This study evaluated patients with diabetes and ED without any history of cardiac symptoms or signs...
September 2016: Sexual Medicine
Andrew T Goldstein, Michelle A King
INTRODUCTION: Ospemifene (Osphena, Shionogi Inc, Florham, NJ, USA) is an estrogen agonist and antagonist approved by the U.S. Federal Drug Administration for the treatment of "moderate to severe dyspareunia, a symptom of vulvar and vaginal atrophy, due to menopause." Although published, peer-reviewed, placebo-controlled studies have shown objective improvement in dyspareunia and in vaginal atrophy, there are no published data that have assessed changes in vulvar atrophy after the use of ospemifene...
September 2016: Sexual Medicine
Arik Shechter, Lior Lowenstein, Ege Can Serefoglu, Yacov Reisman
INTRODUCTION: Premature ejaculation (PE) is one of the commonest sexual dysfunctions in men. Because the definition of and guidelines for the management of PE have been revised in recent years, our understanding of PE has changed. AIM: To investigate the clinical practice patterns of sexual medicine specialists regarding the diagnosis and treatment of PE. METHODS: Attendees of the 17th Annual Congress of the European Society of Sexual Medicine, held in February 2015 in Copenhagen, Denmark, were asked to participate in a survey during the congress...
September 2016: Sexual Medicine
Mats B Humble, Susanne Bejerot
INTRODUCTION: Serotonin reuptake inhibitors (SRIs) are widely used for the treatment of psychiatric disorders, including obsessive-compulsive disorder (OCD). SRIs commonly cause delayed orgasm, the mechanism of which is poorly understood. Oxytocin is involved in sexual function and is interconnected with serotonin within the brain. SRIs are reported to affect the oxytocin system, but possible relations between SRI-induced changes of sexual function and oxytocin are unexplored in humans...
September 2016: Sexual Medicine
Mary Clegg, Joanne Pye, Kevan R Wylie
INTRODUCTION: It has been suggested that an indicator of a doctor's ability to assess patients' sexual function relates to the level of earlier training. The amount and quality of training the doctor receives at the undergraduate level and beyond could contribute to the doctor's confidence and competence. AIMS: To evaluate whether doctors found that the teaching in human sexuality received at medical school was sufficient for their future practice and whether their chosen medical specialty and exposure to issues related to sexual health affected this opinion...
September 2016: Sexual Medicine
Hyun Jun Park, Tae Nam Kim, Seung Ryong Baek, Kyung Min Lee, Kyung-Un Choi, Nam Cheol Park
INTRODUCTION: Traumatic neuroma is a reactive process caused by the regeneration of an injured nerve that usually forms a nodular proliferation of small nerve bundles. Penile traumatic neuroma is rare; only a few cases related to circumcision have been reported. AIM: To report on a case of traumatic neuroma in the penis after selective dorsal neurotomy (SDN) to treat premature ejaculation. METHODS: The penile traumatic neuroma was successfully removed by excision and confirmed by histopathology...
September 2016: Sexual Medicine
William D Winkelman, Patricia P Katz, James F Smith, Tami S Rowen
INTRODUCTION: Infertility affects approximately 6.7 million women in the United States. Couples with infertility have significantly more anxiety, depression, and stress. This is compounded by the fact that almost 40% of couples undergoing assisted reproduction technology still cannot conceive, which can have an ongoing effect on quality of life, marital adjustment, and sexual impact. AIM: To assess the sexual impact of infertility in women undergoing fertility treatment...
September 2016: Sexual Medicine
Ridwan Shabsigh, Andreas Mattern
INTRODUCTION: Erectile dysfunction (ED) is prevalent in men with metabolic syndrome (MetS); therefore, it is important to characterize ED treatments in this population. AIMS: To investigate the safety and effectiveness of vardenafil in men with ED and MetS in a clinical setting. METHODS: REVITALISE is an international, prospective, single-arm, observational study in men with ED and MetS newly prescribed vardenafil. Vardenafil was prescribed at the discretion of the treating physician in line with the marketing authorization...
September 2016: Sexual Medicine
Sue W Goldstein, Joshua R Gonzalez, Catherine Gagnon, Irwin Goldstein
INTRODUCTION: Female sexual arousal disorder is a pathophysiologic state characterized clinically by persistent or recurrent inability to attain or maintain an adequate lubrication-swelling response of sexual excitement until completion of sexual activity. Prior clinical experience with alprostadil products for men with erectile dysfunction supports its use in women with female sexual arousal disorder. AIM: To compare the effect of topical alprostadil with over-the-counter (OTC) lubricant on female genital arousal in the absence of visual sexual stimuli...
September 2016: Sexual Medicine
Giovanni Castellini, Egidia Fanni, Giovanni Corona, Elisa Maseroli, Valdo Ricca, Mario Maggi
INTRODUCTION: Attitudes toward masturbation are extremely varied, and this practice is often perceived with a sense of guilt. AIM: To evaluate the prevalence of ego-dystonic masturbation (EM), defined as masturbation activity followed by a sense of guilt, in a clinical setting of sexual medicine and the impact of EM on psychological and relational well-being. METHODS: A series of 4,211 men attending an andrology and sexual medicine outpatient clinic was studied retrospectively...
September 2016: Sexual Medicine
Christopher Quinn-Nilas, Lindsay Benson, Robin R Milhausen, Andrea C Buchholz, Melissa Goncalves
INTRODUCTION: Research suggests that body image affects sexual functioning, but the relationship between specific types of body image (evaluative, affective, and behavioral) and domains of sexual functioning (desire, arousal, and orgasm) has not been investigated. AIM: To determine whether, and to what degree, body image concerns (evaluative, affective, and behavioral) influence aspects of women's sexual functioning (desire, arousal, and orgasm). METHODS: Eighty-eight sexually active women in heterosexual romantic relationships completed surveys assessing evaluative, affective, and behavioral body image and sexual functioning...
September 2016: Sexual Medicine
Susan H Oakley, J Walther-Liu, C C Crisp, R N Pauls
INTRODUCTION: Female sexual dysfunction affects up to 43% of women in the United States and hypoactive sexual desire disorder (HSDD) is the most common type; however, we lack treatment options showing improvement for this condition. AIMS: To investigate whether acupuncture therapy could improve HSDD. METHODS: Premenopausal women with a primary diagnosis of HSDD were included in a single-arm prospective pilot study that was approved by the institutional review board...
September 2016: Sexual Medicine
Thiago Gagliano-Jucá, Mauro Napolitano, Fernanda Del Grossi Ferraz Carvalho, Rafael Campos, Fabíola Zakia Mónica, Mário Angelo Claudino, Edson Antunes, Anibal Gil Lopes, Gilberto De Nucci
INTRODUCTION: Hydrochlorothiazide has a negative influence on penile erection but little is known about the mechanism(s) involved. AIMS: To characterize the effects of this diuretic on mouse corpus cavernosum (CC) smooth muscle in vitro and ex vivo. METHODS: CC strips of C57BL/6 mice (12-16 weeks old) were mounted in organ baths containing Krebs-Henseleit solution and tissue reactivity was evaluated. Expression of genes encoding diuretic targets and enzymes involved in penile erection were evaluated by polymerase chain reaction...
June 2016: Sexual Medicine
Martin Kuete, Hongfang Yuan, Qian He, Aude Laure Tchoua Kemayou, Tita Pale Ndognjem, Fan Yang, ZhiZong Hu, BoZhen Tian, Kai Zhao, HuiPing Zhang, ChengLiang Xiong
INTRODUCTION: The sexual and reproductive health of people living with HIV is fundamental for their well-being. Antiretroviral therapy and reproductive technologies have significantly improved quality of life of people living with HIV in developed countries. In sub-Saharan Africa, the epicenter of HIV, the sexual practices and fertility of women infected with HIV have been understudied. AIM: To assess the sexual behavior, fertility intentions, and awareness of preventing mother-to-child transmission of HIV in pregnant women with HIV-negative partners in Yaounde Central Hospital (Yaounde, Cameroon)...
June 2016: Sexual Medicine
Alessandro Zucchi, Elisabetta Costantini, Tommaso Cai, Giorgio Cavallini, Giovanni Liguori, Vincenzo Favilla, Gaetano De Grande, Giuseppe D'Achille, Mauro Silvani, Giorgio Franco, Alessandro Palmieri, Paolo Verze, Vincenzo Mirone
INTRODUCTION: Hyaluronic acid has been shown to be efficacious in decreasing scar formation, inflammation, and oxidative stress. AIM: To assess the efficacy of intralesional injection of hyaluronic acid in patients affected by Peyronie's disease. METHODS: In this prospective, single-arm, self-controlled, interventional, multicenter pilot study, 65 patients underwent a 10-week cycle of weekly intraplaque injections with hyaluronic acid (0.8% highly purified sodium salt hyaluronic acid 16 mg/2 mL; Sinovial, IBSA, Lodi, Italy)...
June 2016: Sexual Medicine
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