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Journal of Molecular Psychiatry

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https://www.readbyqxmd.com/read/27429752/unified-theory-of-alzheimer-s-disease-utad-implications-for-prevention-and-curative-therapy
#1
REVIEW
Michael Nehls
The aim of this review is to propose a Unified Theory of Alzheimer's disease (UTAD) that integrates all key behavioural, genetic and environmental risk factors in a causal chain of etiological and pathogenetic events. It is based on three concepts that emanate from human's evolutionary history: (1) The grandmother-hypothesis (GMH), which explains human longevity due to an evolutionary advantage in reproduction by trans-generational transfer of acquired knowledge. Consequently it is argued that mental health at old-age must be the default pathway of humans' genetic program and not development of AD...
2016: Journal of Molecular Psychiatry
https://www.readbyqxmd.com/read/27330745/%C3%AE-t-catenin-in-restricted-brain-cell-types-and-its-potential-connection-to-autism
#2
Stephen Sai Folmsbee, Douglas R Wilcox, Koen Tyberghein, Pieter De Bleser, Warren G Tourtellotte, Jolanda van Hengel, Frans van Roy, Cara J Gottardi
BACKGROUND: Recent genetic association studies have linked the cadherin-based adherens junction protein alpha-T-catenin (αT-cat, CTNNA3) with the development of autism. Where αT-cat is expressed in the brain, and how its loss could contribute to this disorder, are entirely unknown. METHODS: We used the αT-cat knockout mouse to examine the localization of αT-cat in the brain, and we used histology and immunofluorescence analysis to examine the neurobiological consequences of its loss...
2016: Journal of Molecular Psychiatry
https://www.readbyqxmd.com/read/27103995/de-novo-pogz-mutations-in-sporadic-autism-disrupt-the-dna-binding-activity-of-pogz
#3
Kensuke Matsumura, Takanobu Nakazawa, Kazuki Nagayasu, Nanaka Gotoda-Nishimura, Atsushi Kasai, Atsuko Hayata-Takano, Norihito Shintani, Hidenaga Yamamori, Yuka Yasuda, Ryota Hashimoto, Hitoshi Hashimoto
BACKGROUND: A spontaneous de novo mutation is a new mutation appeared in a child that neither the parent carries. Recent studies suggest that recurrent de novo loss-of-function mutations identified in patients with sporadic autism spectrum disorder (ASD) play a key role in the etiology of the disorder. POGZ is one of the most recurrently mutated genes in ASD patients. Our laboratory and other groups have recently found that POGZ has at least 18 independent de novo possible loss-of-function mutations...
2016: Journal of Molecular Psychiatry
https://www.readbyqxmd.com/read/26457184/prevalence-of-mental-distress-and-associated-factors-among-caregivers-of-patients-with-severe-mental-illness-in-the-outpatient-unit-of-amanuel-hospital-addis-ababa-ethiopia-2013-cross-sectional-study
#4
Mezinew Sintayehu, Haregwoin Mulat, Zegeye Yohannis, Tewodros Adera, Maereg Fekade
BACKGROUND: Caregivers like family members or other relatives are central and provide not only practical help and personal care but also give emotional support, and they are suffering from plenty of challengeable tasks. These, eventually, cast out family caregivers into multidimensional problems prominently for mental distress like depression, anxiety, sleep problem and somatic disorder which are followed by physiologic changes and impaired health habits that ultimately lead to illness and possibly to death...
2015: Journal of Molecular Psychiatry
https://www.readbyqxmd.com/read/26421149/preparation-for-teacher-collaboration-in-inclusive-classrooms-stress-reduction-for-special-education-students-via-acceptance-and-commitment-training-a-controlled-study
#5
Simone Pülschen, Dietrich Pülschen
BACKGROUND: The education system in Germany is beginning to witness a sea change, lately, owing to the country's ratification of the United Nation's Convention on the Rights of Persons with Disabilities. The enactment is aiming at making provision for special education teachers to share the same teaching platform and institution with other teachers for teaching children from all backgrounds, irrespective of their needs. While promoting the benefits of collaborative teaching, this provision would also effectively establish role demarcation among teachers...
2015: Journal of Molecular Psychiatry
https://www.readbyqxmd.com/read/26137221/insights-into-the-origin-of-dna-methylation-differences-between-monozygotic-twins-discordant-for-schizophrenia
#6
Melkaye G Melka, Christina A Castellani, Richard O'Reilly, Shiva M Singh
BACKGROUND: DNA methylation differences between monozygotic twins discordant for schizophrenia have been previously reported. However, the origin of methylation differences between monozygotic twins discordant for schizophrenia is not clear. The findings here argue that all DNA methylation differences may not necessarily represent the cause of the disease; rather some may result from the effect of antipsychotics. METHODS: Methylation differences in rat brain regions and also in two pairs of unrelated monozygotic twins discordant for schizophrenia have been studied using genome-wide DNA methylation arrays at Arraystar Inc...
2015: Journal of Molecular Psychiatry
https://www.readbyqxmd.com/read/26110057/characterization-of-cognitive-deficits-in-spontaneously-hypertensive-rats-accompanied-by-brain-insulin-receptor-dysfunction
#7
Edna Grünblatt, Jasmin Bartl, Diana-Iulia Iuhos, Ana Knezovic, Vladimir Trkulja, Peter Riederer, Susanne Walitza, Melita Salkovic-Petrisic
BACKGROUND: The spontaneously hypertensive rat (SHR) has been used to model changes in the central nervous system associated with cognitive-related disorders. Recent human and animal studies indicate a possible relationship between cognitive deficits, insulin resistance and hypertension. We aimed to investigate whether cognitively impaired SHRs develop central and/or peripheral insulin resistance and how their cognitive performance is influenced by the animal's sex and age as well as strains used for comparison (Wistar and Wistar-Kyoto/WKY)...
2015: Journal of Molecular Psychiatry
https://www.readbyqxmd.com/read/26064521/effects-of-physical-exercise-on-central-nervous-system-functions-a-review-of-brain-region-specific-adaptations
#8
Julie A Morgan, Frances Corrigan, Bernhard T Baune
Pathologies of central nervous system (CNS) functions are involved in prevalent conditions such as Alzheimer's disease, depression, and Parkinson's disease. Notable pathologies include dysfunctions of circadian rhythm, central metabolism, cardiovascular function, central stress responses, and movement mediated by the basal ganglia. Although evidence suggests exercise may benefit these conditions, the neurobiological mechanisms of exercise in specific brain regions involved in these important CNS functions have yet to be clarified...
2015: Journal of Molecular Psychiatry
https://www.readbyqxmd.com/read/26019867/behavioral-disorders-and-cognitive-impairment-associated-with-cerebellar-lesions
#9
Stefan Grossauer, Katharina Koeck, Thomas Kau, Joerg Weber, Giles H Vince
In the last decade evidence has accumulated that suggests that the cerebellum is involved not only in motor but also in behavioral and cognitive functions. A myriad of anatomical, clinical and imaging studies support that assumption. The lengthened survival of patients with cerebellar tumors has also brought an increased awareness of neurocognitive deficits to the neurooncological community. Although evidence from neurosurgical case series exists that clearly demonstrates that patients afflicted from posterior fossa tumors are at high risk for long-term cognitive or adaptive deficits, there is still a lack of systematic translational review on this issue...
2015: Journal of Molecular Psychiatry
https://www.readbyqxmd.com/read/25932327/a-systematic-review-of-agomelatine-induced-liver-injury
#10
Silka Dawn Freiesleben, Karolina Furczyk
Agomelatine is an antidepressant with a unique mechanism of action. Since its marketing in 2009, concerns have been raised regarding its potential to induce liver injury. The authors therefore address the need to comprehensively evaluate the potential risk posed by agomelatine of inducing liver injury by reviewing data from published and unpublished clinical trials in both the pre- and postmarketing settings, as well as data from non-interventional studies, pharmacovigilance database reviews and one case report...
2015: Journal of Molecular Psychiatry
https://www.readbyqxmd.com/read/25848535/metabolite-profiling-in-posttraumatic-stress-disorder
#11
Alexander Karabatsiakis, Gilava Hamuni, Sarah Wilker, Stephan Kolassa, Durairaj Renu, Suzanne Kadereit, Maggie Schauer, Thomas Hennessy, Iris-Tatjana Kolassa
BACKGROUND: Traumatic stress does not only increase the risk for posttraumatic stress disorder (PTSD), but is also associated with adverse secondary physical health outcomes. Despite increasing efforts, we only begin to understand the underlying biomolecular processes. The hypothesis-free assessment of a wide range of metabolites (termed metabolite profiling) might contribute to the discovery of biological pathways underlying PTSD. METHODS: Here, we present the results of the first metabolite profiling study in PTSD, which investigated peripheral blood serum samples of 20 PTSD patients and 18 controls...
2015: Journal of Molecular Psychiatry
https://www.readbyqxmd.com/read/25810915/sleep-hygiene-awareness-its-relation-to-sleep-quality-and-diurnal-preference
#12
Bogdan Ioan Voinescu, Aurora Szentagotai-Tatar
BACKGROUND: Sleep hygiene is a core component for psychological treatments of insomnia and essential for maintaining a satisfactory sleep. Our study aimed to measure the sleep hygiene awareness and the self-reported quality of sleep among three age groups (young adults, adults and middle-aged adults) and to determine their relation. We also measured their relation with diurnal preference. METHODS: Using an online questionnaire, we surveyed six hundred fifty two participants, recruited nationwide from the community and from the students in three main cities in Romania...
2015: Journal of Molecular Psychiatry
https://www.readbyqxmd.com/read/25945249/sluggish-cognitive-tempo-and-its-neurocognitive-social-and-emotive-correlates-a-systematic-review-of-the-current-literature
#13
REVIEW
Anna Katharina Mueller, Lara Tucha, Janneke Koerts, Yvonne Groen, Klaus W Lange, Oliver Tucha
OBJECTIVES: Since the elimination of items associated with Sluggish Cognitive Tempo (SCT) during the transition from DSM-III to DSM-IV from the diagnostic criteria of Attention-deficit Hyperactivity Disorder (ADHD), interest in SCT and its associated cognitive as well as emotional and social consequences is on the increase. The current review discusses recent findings on SCT in clinical as well as community based ADHD populations. The focus is further on clinical correlates of SCT in populations different from ADHD, SCT's genetic background, SCT's association with internalizing and other behavioral comorbidities, as well as SCT's association with social functioning and its treatment efficacy...
2014: Journal of Molecular Psychiatry
https://www.readbyqxmd.com/read/25945248/hiv-associated-neurocognitive-disorders
#14
REVIEW
Montserrat Sanmarti, Laura Ibáñez, Sonia Huertas, Dolors Badenes, David Dalmau, Mark Slevin, Jerzy Krupinski, Aurel Popa-Wagner, Angeles Jaen
Currently, neuropsychological impairment among HIV+ patients on antiretroviral therapy leads to a reduction in the quality of life and it is an important challenge due to the high prevalence of HIV-associated neurocognitive disorders and its concomitant consequences in relation to morbidity and mortality- including those HIV+ patients with adequate immunological and virological status. The fact that the virus is established in CNS in the early stages and its persistence within the CNS can help us to understand HIV-related brain injury even when highly active antiretroviral therapy is effective...
2014: Journal of Molecular Psychiatry
https://www.readbyqxmd.com/read/25713723/mitochondrial-complex-i-and-iii-gene-mrna-levels-in-schizophrenia-and-their-relationship-with-clinical-features
#15
Süleyman Akarsu, Deniz Torun, Abdullah Bolu, Murat Erdem, Salih Kozan, Mehmet Ak, Hatice Akar, Özcan Uzun
BACKGROUND: The etiology of schizophrenia is not precisely known; however, mitochondrial function and cerebral energy metabolism abnormalities were determined to be possible factors associated with the etiology of schizophrenia. Impaired mitochondrial function negatively affects neuronal plasticity, and can cause cognitive deficits and behavioral abnormalities observed during the clinical course of schizophrenia. The present study aimed to investigate the relationship between the clinical features of schizophrenia, and mitochondrial complex activation, based on measurement of mRNA levels in the NDUFV1, NDUFV2, NDUFS1, and UQCR10 genes involved in the peripheral mitochondrial complex...
2014: Journal of Molecular Psychiatry
https://www.readbyqxmd.com/read/25408914/the-relationship-between-irritable-bowel-syndrome-and-psychiatric-disorders-from-molecular-changes-to-clinical-manifestations
#16
REVIEW
Mihaela Fadgyas-Stanculete, Ana-Maria Buga, Aurel Popa-Wagner, Dan L Dumitrascu
Irritable bowel syndrome (IBS) is a functional syndrome characterized by chronic abdominal pain accompanied by altered bowel habits. Although generally considered a functional disorder, there is now substantial evidence that IBS is associated with a poor quality of life and significant negative impact on work and social domains. Neuroimaging studies documented changes in the prefrontal cortex, ventro-lateral and posterior parietal cortex and thalami, and implicate alteration of brain circuits involved in attention, emotion and pain modulation...
2014: Journal of Molecular Psychiatry
https://www.readbyqxmd.com/read/25408913/centenary-of-karl-jaspers-s-general-psychopathology-implications-for-molecular-psychiatry
#17
REVIEW
Johannes Thome
Modern molecular psychiatry benefits immensely from the scientific and technological advances of general neuroscience (including genetics, epigenetics, and proteomics). This "progress" of molecular psychiatry, however, will be to a degree "unbalanced" and "epiphytic" should the development of the corresponding theoretical frameworks and conceptualization tools that allow contextualization of the individual neuroscientific findings within the specific perspective of mental health care issues be neglected. The General Psychopathology, published by Karl Jaspers in 1913, is considered a groundbreaking work in psychiatric literature, having established psychopathology as a space of critical methodological self-reflection, and delineating a scientific methodology specific to psychiatry...
2014: Journal of Molecular Psychiatry
https://www.readbyqxmd.com/read/25408912/association-study-in-siblings-and-case-controls-of-serotonin-and-oxytocin-related-genes-with-high-functioning-autism
#18
Johanna Nyffeler, Susanne Walitza, Elise Bobrowski, Ronnie Gundelfinger, Edna Grünblatt
BACKGROUND: Autism spectrum disorder (ASD) is heritable and neurodevelopmental with unknown causes. The serotonergic and oxytocinergic systems are of interest in autism for several reasons: (i) Both systems are implicated in social behavior, and abnormal levels of serotonin and oxytocin have been found in people with ASD; (ii) treatment with selective serotonin reuptake inhibitors and oxytocin can yield improvements; and (iii) previous association studies have linked the serotonin transporter (SERT; SLC6A4), serotonin receptor 2A (HTR2A), and oxytocin receptor (OXTR) genes with ASD...
2014: Journal of Molecular Psychiatry
https://www.readbyqxmd.com/read/26019866/astrocytes-reassessment-an-evolving-concept-part-one-embryology-biology-morphology-and-reactivity
#19
REVIEW
Alina Simona Şovrea, Adina Bianca Boşca
The goal of this review is to integrate - in its two parts - the considerable amount of information that has accumulated during these recent years over the morphology, biology and functions of astrocytes - first part - and to illustrate the active role of these cells in pathophysiological processes implicated in various psychiatric and neurologic disorders - second part.
2013: Journal of Molecular Psychiatry
https://www.readbyqxmd.com/read/26019865/the-nucleus-accumbens-a-target-for-deep-brain-stimulation-in-resistant-major-depressive-disorder
#20
REVIEW
Cecilia Nauczyciel, Suzanne Robic, Thibaut Dondaine, Marc Verin, Gabriel Robert, Dominique Drapier, Florian Naudet, Bruno Millet
OBJECTIVE: This review aimed to investigate the therapeutic potential of Deep Brain Stimulation (DBS) for treating resistant Major Depressive Disorder (MDD). We explored the role of Nucleus accumbens (Nac) as a target for treatment. METHOD: We made a systematic review of all studies examining the mechanisms of action of high frequency brain stimulation and the pathophysiology of MDD. We also reported all the studies exploring the therapeutic potential of DBS in MDD...
2013: Journal of Molecular Psychiatry
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