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Journal of Cancer Prevention

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https://www.readbyqxmd.com/read/28382287/-p53-polymorphism-at-codon-72-and-breast-cancer-letter
#1
COMMENT
Fahimeh Afzaljavan, Alireza Pasdar
No abstract text is available yet for this article.
March 2017: Journal of Cancer Prevention
https://www.readbyqxmd.com/read/28382286/non-homologous-end-joining-inhibitor-scr-7-to-exacerbate-low-dose-doxorubicin-cytotoxicity-in-hela-cells
#2
Ajay Kumar, Devyani Bhatkar, Devashree Jahagirdar, Nilesh Kumar Sharma
Among the genotoxic drug regimens, doxorubicin (DOX) is known for its high-dose side effects in several carcinomas, including cervical cancer. This study reports on testing the combined use of a DOX genotoxic drug and SCR-7 non-homologous end joining (NHEJ) inhibitor for HeLa cells. An in vitro DNA damaging assay of DOX was performed on plasmid and genomic DNA substrate. In vitro cytotoxicity was investigated using trypan blue dye exclusion, DNA metabolizing, and propidium iodide-based flow cytometric assays...
March 2017: Journal of Cancer Prevention
https://www.readbyqxmd.com/read/28382285/anti-proliferative-effects-of-androctonus-amoreuxi-scorpion-and-cerastes-cerastes-snake-venoms-on-human-prostate-cancer-cells
#3
Hassan Akef, Nahla Kotb, Dina Abo-Elmatty, Sayed Salem
The present study evaluated the effects of Androctonus amoreuxi scorpion venom, Cerastes cerastes snake venom and their mixture on prostate cancer cells (PC3). An MTT assay was used to determine the anti-proliferative effect of the venoms, while quantitative real time PCR was used to evaluate the expression of apoptosis-related genes (Bax and Bcl-2). Furthermore, colorimetric assays were used to measure the levels of malondialdehyde (MDA) and antioxidant enzymes. Our results show that the venoms significantly reduced PC3 cell viability in a dose-dependent manner...
March 2017: Journal of Cancer Prevention
https://www.readbyqxmd.com/read/28382284/differential-microrna-expression-between-gastric-cancer-tissue-and-non-cancerous-gastric-mucosa-according-to-helicobacter-pylori-status
#4
Jung Won Lee, Nayoung Kim, Ji Hyun Park, Hee Jin Kim, Hyun Chang, Jung Min Kim, Jin-Wook Kim, Dong Ho Lee
BACKGROUND: MicroRNAs (miRNAs) are key post-translational mechanisms which can regulate gene expression in gastric carcinogenesis. To identify miRNAs responsible for gastric carcinogenesis, we compared expression levels of miRNAs between gastric cancer tissue and non-cancerous gastric mucosa according to Helicobacter pylori status. METHODS: Total RNA was extracted from the cancerous regions of formalin-fixed, paraffin-embedded tissues of H. pylori-positive (n = 8) or H...
March 2017: Journal of Cancer Prevention
https://www.readbyqxmd.com/read/28382283/protective-effect-of-white-fleshed-peach-prunus-persica-l-batsch-on-chronic-nicotine-induced-toxicity
#5
Hyun-Jeong Kim, Kwang-Kyun Park, Won-Yoon Chung, Sun Kyoung Lee, Ki-Rim Kim
BACKGROUND: Nicotine is a major toxic component of tobacco smoke and has been recognized as a risk factor to induce oxidative tissue damage, which is a precursor to cardiovascular diseases, lung-related diseases, and cancers. Peaches (Prunus persica) have been used for the treatment of degenerative disorders, such as hypermenorrhea, dysmenorrhea, and infertility in Asian countries. In this study, we investigated the effects of white-fleshed peach on the excretion of nicotine metabolites and 1-hydroxypyrene in smokers and chronic nicotine-induced tissue damages in mice...
March 2017: Journal of Cancer Prevention
https://www.readbyqxmd.com/read/28382282/ursodeoxycholic-acid-induces-death-receptor-mediated-apoptosis-in-prostate-cancer-cells
#6
Won Sup Lee, Ji Hyun Jung, Radha Panchanathan, Jeong Won Yun, Dong Hoon Kim, Hye Jung Kim, Gon Sup Kim, Chung Ho Ryu, Sung Chul Shin, Soon Chan Hong, Yung Hyun Choi, Jin-Myung Jung
BACKGROUND: Bile acids have anti-cancer properties in a certain types of cancers. We determined anticancer activity and its underlying molecular mechanism of ursodeoxycholic acid (UDCA) in human DU145 prostate cancer cells. METHODS: Cell viability was measured with an MTT assay. UDCA-induced apoptosis was determined with flow cytometric analysis. The expression levels of apoptosis-related signaling proteins were examined with Western blotting. RESULTS: UDCA treatment significantly inhibited cell growth of DU145 in a dose-dependent manner...
March 2017: Journal of Cancer Prevention
https://www.readbyqxmd.com/read/28382281/predictive-and-prognostic-biomarkers-of-respiratory-diseases-due-to-particulate-matter-exposure
#7
REVIEW
Hyo Jeong Kim, Min Gi Choi, Moo Kyun Park, Young Rok Seo
Air pollution is getting severe and concerns about its toxicity effects on airway and lung disease are also increasing. Particulate matter (PM) is major component of air pollutant. It causes respiratory diseases, such as asthma, chronic obstructive pulmonary disease, lung cancer, and so on. PM particles enter the airway and lung by inhalation, causing damages to them. Especially, PM2.5 can penetrate into the alveolus and pass to the systemic circulation. It can affect the cardiopulmonary system and cause cardiopulmonary disorders...
March 2017: Journal of Cancer Prevention
https://www.readbyqxmd.com/read/28382280/anti-cancer-mechanism-of-docosahexaenoic-acid-in-pancreatic-carcinogenesis-a-mini-review
#8
REVIEW
Mirae Park, Hyeyoung Kim
Pancreatic cancer is a highly aggressive malignant tumor of the digestive system and radical resection, which is available to very few patients, might be the only possibility for cure. Since therapeutic choices are limited at the advanced stage, prevention is more important for reducing incidence in high-risk individuals with family history of pancreatic cancer. Epidemiological studies have shown that a high consumption of fish oil or ω3-polyunsaturated fatty acids reduces the risk of pancreatic cancers. Dietary fish oil supplementation has shown to suppress pancreatic cancer development in animal models...
March 2017: Journal of Cancer Prevention
https://www.readbyqxmd.com/read/28053966/erratum-diagnostic-value-of-combining-tumor-and-inflammatory-markers-in-lung-cancer
#9
Ho Il Yoon, Oh-Ran Kwon, Kyung Nam Kang, Yong Sung Shin, Ho Sang Shin, Eun Hee Yeon, Keon Young Kwon, Ilseon Hwang, Yun Kyung Jeon, Yongdai Kim, Chul Woo Kim
[This corrects the article on p. 187 in vol. 21, PMID: 27722145.].
December 2016: Journal of Cancer Prevention
https://www.readbyqxmd.com/read/28053965/the-role-of-oral-contraceptive-pills-on-increased-risk-of-breast-cancer-in-iranian-populations-a-meta-analysis
#10
Ali Soroush, Negin Farshchian, Saeid Komasi, Neda Izadi, Nasrin Amirifard, Afshar Shahmohammadi
BACKGROUND: Cancer is one of the main public health issues in the world. Breast cancer is one of the most common types of cancer among women. It is also the second cause of mortality in women. The association between the use of oral contraceptive pills and breast cancer is controversial and a main issue in public health. Some findings have shown that taking these pills does not have a significant effect in increasing the risk of breast cancer, while others have confirmed the carcinogenic effect of these products...
December 2016: Journal of Cancer Prevention
https://www.readbyqxmd.com/read/28053964/the-evaluation-of-p53-polymorphism-at-codon-72-and-association-with-breast-cancer-in-iran-a-systematic-review-and-meta-analysis
#11
Abozar Soleimani, Yousef Rahmani, Negin Farshchian, Ali Delpisheh, Kivan Khassi, Afshar Shahmohammadi, Nasrin Amirifard
BACKGROUND: Breast cancer is the most common cancer among women in Iran and the world. Multiple environmental factors and genetic variations such as genetic polymorphisms are of its main causes. p53 gene plays an important role in conserving and sustaining the genome as a tumor suppressing gene. Change and polymorphism at codon 72 of p53 gene are correlated with increased risk of lung, mouth, endometrial, prostate, and colorectal cancers, and could be considered an indicator of susceptibility to breast cancer...
December 2016: Journal of Cancer Prevention
https://www.readbyqxmd.com/read/28053963/expression-of-leucine-rich-repeat-containing-g-protein-coupled-receptor-5-and-cd44-potential-implications-for-gastric-cancer-stem-cell-marker
#12
Yoon Jin Choi, Nayoung Kim, Hye Seung Lee, Seon Mee Park, Ji Hyun Park, Hyuk Yoon, Cheol Min Shin, Young Soo Park, Jin-Wook Kim, Dong Ho Lee
BACKGROUND: The human leucine-rich repeat-containing G-protein coupled receptor (LGR) 5 and CD44 are one of the candidates for the marker of gastric cancer stem cells. We compared the expressions of two genes among control, dysplasia and cancer groups. METHODS: We compared the mRNA expression of LGR5, CD44 and CD44v8-10 and immunohistochemistry (IHC) of LGR5 and CD44 in gastric antral mucosa of 45 controls, 36 patients with gastric dysplasia, and 39 patients with early gastric cancer...
December 2016: Journal of Cancer Prevention
https://www.readbyqxmd.com/read/28053962/the-effect-of-sex-on-the-azoxymethane-dextran-sulfate-sodium-treated-mice-model-of-colon-cancer
#13
Sun Min Lee, Nayoung Kim, Hee Jin Son, Ji Hyun Park, Ryoung Hee Nam, Min Hee Ham, Daeun Choi, Sung Hwa Sohn, Eun Shin, Young-Jae Hwang, Jihee Sung, Dong Ho Lee, Ha-Na Lee
BACKGROUND: The colitis-associated cancer exhibits different characteristics according to sex in the initiation and progression of the tumors. The aim of this study was to investigate the sex-associated difference in the azoxymethane/dextran sulfate sodium (AOM/DSS)-induced colitis-associated cancer model. METHODS: The AOM/DSS ICR mouse model was established to compare male with female, and then the severity of colitis-associated carcinogenesis was examined macroscopically and histologically regarding the number, size, and location of tumors...
December 2016: Journal of Cancer Prevention
https://www.readbyqxmd.com/read/28053961/iron-supplementation-reverses-the-reduction-of-hydroxymethylcytosine-in-hepatic-dna-associated-with-chronic-alcohol-consumption-in-rats
#14
Stephanie A Tammen, Jung Eun Park, Phil Kyung Shin, Simonetta Friso, Jayong Chung, Sang-Woon Choi
BACKGROUND: Alcohol is known to affect two epigenetic phenomena, DNA methylation and DNA hydroxymethylation, and iron is a cofactor of ten-eleven translocation (TET) enzymes that catalyze the conversion from methylcytosine to hydroxymethylcytosine. In the present study we aimed to determine the effects of alcohol on DNA hydroxymethylation and further effects of iron on alcohol associated epigenetic changes. METHODS: Twenty-four male Sprague-Dawley rats were fed either Lieber-DeCarli alcohol diet (36% calories from ethanol) or Lieber-DeCarli control diet along with or without iron supplementation (0...
December 2016: Journal of Cancer Prevention
https://www.readbyqxmd.com/read/28053960/protective-effect-of-an-isoflavone-tectorigenin-against-oxidative-stress-induced-cell-death-via-catalase-activation
#15
Rui Zhang, Mei Jing Piao, Min Chang Oh, Jeong Eon Park, Kristina Shilnikova, Yu Jin Moon, Dong Hyun Kim, Uhee Jung, In Gyu Kim, Jin Won Hyun
BACKGROUND: Isoflavones are biologically active compounds that occur naturally in a variety of plants, with relatively high levels in soybean. Tectorigenin, an isoflavone, protects against hydrogen peroxide (H2O2)-induced cell damage. However, the underlying mechanism is unknown. METHODS: The MTT assay was performed to determine cell viability. Catalase activity was assessed by determining the amount of enzyme required to degrade 1 μM H2O2. Protein expression of catalase, phospho-extracellular signal-regulated kinase (ERK), IκB-α, and NF-κB were evaluated by Western blot analysis...
December 2016: Journal of Cancer Prevention
https://www.readbyqxmd.com/read/28053959/sorbus-rufopilosa-extract-exhibits-antioxidant-and-anticancer-activities-by-inducing-cell-cycle-arrest-and-apoptosis-in-human-colon-adenocarcinoma-ht29-cells
#16
You Na Oh, Soojung Jin, Hyun-Jin Park, Hyun Ju Kwon, Byung Woo Kim
BACKGROUND: Sorbus rufopilosa, a tsema rowan, is a species of the small ornamental trees in the genus Sorbus and the family Rosaceae found in East Asia. The bioactivities of S. rufopilosa have not yet been fully determined. The objective of this study is to evaluate the antioxidant and anticancer effects of ethanol extract of S. rufopilosa (EESR) and to determine the molecular mechanism of its anticancer activity in human colon carcinoma HT29 cells. METHODS: To examine the antioxidant activity of EESR, 2,2-diphenyl-1-picrylhydrazyl radical scavenging activity assay was performed...
December 2016: Journal of Cancer Prevention
https://www.readbyqxmd.com/read/28053958/inducible-mouse-models-for-cancer-drug-target-validation
#17
REVIEW
Joseph H Jeong
Genetically-engineered mouse (GEM) models have provided significant contributions to our understanding of cancer biology and developing anticancer therapeutic strategies. The development of GEM models that faithfully recapitulate histopathological and clinical features of human cancers is one of the most pressing needs to successfully conquer cancer. In particular, doxycycline-inducible transgenic mouse models allow us to regulate (induce or suppress) the expression of a specific gene of interest within a specific tissue in a temporal manner...
December 2016: Journal of Cancer Prevention
https://www.readbyqxmd.com/read/28053957/identification-of-biomarkers-for-breast-cancer-using-databases
#18
REVIEW
Eunhye Lee, Aree Moon
Breast cancer is one of the major causes of cancer death in women. Many studies have sought to identify specific molecules involved in breast cancer and understand their characteristics. Many biomarkers which are easily measurable, dependable, and inexpensive, with a high sensitivity and specificity have been identified. The rapidly increasing technology development and availability of epigenetic informations play critical roles in cancer. The accumulated data have been collected, stored, and analyzed in various types of databases...
December 2016: Journal of Cancer Prevention
https://www.readbyqxmd.com/read/28053956/aberrant-dna-double-strand-break-repair-threads-in-breast-carcinoma-orchestrating-genomic-insult-survival
#19
REVIEW
Azad Kumar, Shruti Purohit, Nilesh Kumar Sharma
Breast carcinoma is a heterogeneous disease that has exhibited rapid resistance to treatment in the last decade. Depending genotype and phenotype of breast cancer, there are discernible differences in DNA repair protein responses including DNA double strand break repair. It is a fact that different molecular sub-types of breast carcinoma activate these dedicated protein pathways in a distinct manner. The DNA double-strand damage repair machinery is manipulated by breast carcinoma to selectively repair the damage or insults inflicted by the genotoxic effects of chemotherapy or radiation therapy...
December 2016: Journal of Cancer Prevention
https://www.readbyqxmd.com/read/28053955/role-of-apigenin-in-cancer-prevention-via-the-induction-of-apoptosis-and-autophagy
#20
REVIEW
Bokyung Sung, Hae Young Chung, Nam Deuk Kim
Apigenin (4',5,7-trihydroxyflavone) is a flavonoid commonly found in many fruits and vegetables such as parsley, chamomile, celery, and kumquats. In the last few decades, recognition of apigenin as a cancer chemopreventive agent has increased. Significant progress has been made in studying the chemopreventive aspects of apigenin both in vitro and in vivo. Several studies have demonstrated that the anticarcinogenic properties of apigenin occur through regulation of cellular response to oxidative stress and DNA damage, suppression of inflammation and angiogenesis, retardation of cell proliferation, and induction of autophagy and apoptosis...
December 2016: Journal of Cancer Prevention
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