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Journal of Cancer Prevention

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https://www.readbyqxmd.com/read/30003072/erratum-identification-of-epithelial-mesenchymal-transition-related-target-genes-induced-by-the-mutation-of-smad3-linker-phosphorylation
#1
Sujin Park, Kyung-Min Yang, Yuna Park, Eunji Hong, Chang Pyo Hong, Jinah Park, Kyoungwha Pang, Jihee Lee, Bora Park, Siyoung Lee, Haein An, Mi-Kyung Kwak, Junil Kim, Jin Muk Kang, Pyunggang Kim, Yang Xiao, Guangjun Nie, Akira Ooshima, Seong-Jin Kim
[This corrects the article on p. 1 in vol. 23, PMID: 29629343.].
June 2018: Journal of Cancer Prevention
https://www.readbyqxmd.com/read/30003071/leucrose-a-sucrose-isomer-suppresses-hepatic-fat-accumulation-by-regulating-hepatic-lipogenesis-and-fat-oxidation-in-high-fat-diet-induced-obese-mice
#2
Jihye Lee, Eunju Kim, Yuri Kim, Sang-Ho Yoo
Obesity is currently one of the most serious public health problems and it can lead to numerous metabolic diseases. Leucrose, d-glucopyranosyl-α-(1-5)-d-fructopyranose, is an isoform of sucrose and it is naturally found in pollen and honey. The aim of this study was to investigate the effect of leucrose on metabolic changes induced by a high-fat diet (HFD) that lead to obesity. C57BL/6 mice were fed a 60% HFD or a HFD with 25% (L25) or 50% (L50) of its total sucrose content replaced with leucrose for 12 weeks...
June 2018: Journal of Cancer Prevention
https://www.readbyqxmd.com/read/30003070/the-impact-of-implant-location-on-breast-cancer-characteristics-in-previously-augmented-patients-a-systematic-literature-analysis
#3
Alain Joe Azzi, Jordan Gornitsky, Alex Viezel-Mathieu, Lucie Lessard
Background: There is a paucity of data comparing the oncologic properties of breast cancer among patients previously having undergone breast augmentation in either the subglandular or subpectoral planes. The objective of the present systematic review was to evaluate whether implant location influenced the characteristics of breast tumors in previously augmented women. Methods: A systematic literature search was performed to identify relevant articles reporting tumor characteristics in augmented patients...
June 2018: Journal of Cancer Prevention
https://www.readbyqxmd.com/read/30003069/mechanical-alteration-associated-with-chemotherapeutic-resistance-of-breast-cancer-cells
#4
Soyeun Park
Background: The mechanical deformability of cancer cells has attracted particular attention as an emerging biomarker for the prediction of anti-cancer drug sensitivity. Nevertheless, it has not been possible to establish a general rubric for the identification of drug susceptibility in breast cancer cells from a mechanical perspective. In the present study, we investigated the mechanical alteration associated with resistance to adjuvant therapy in breast cancer cells. Methods: We performed an 'atomic force microscopy (AFM)-based nanomechanical study' on 'drug-sensitive (MCF-7)' and 'drug-resistant (MCF-7/ADR)' breast cancer cells...
June 2018: Journal of Cancer Prevention
https://www.readbyqxmd.com/read/30003068/characterization-of-jak2-v617f-1849-g-t-mutation-in-cervical-cancer-related-to-human-papillomavirus-and-sexually-transmitted-infections
#5
Masoumeh Abdolmaleki, Amir Sohrabi
Background: Human papillomavirus (HPV) genotypes that infect the genital tract play a main etiologic role in cervical cancer progression. Other environmental factors, such as sexually transmitted diseases and the host genetic pattern, contribute to infection persistence of the uterus and cervical epithelium in sustaining their malignancy. The Janus kinase 2 is a non-receptor tyrosine kinase in cell signaling process of tumor genesis. In the present study, JAK2 V167F mutation was distinguished in women with sexually transmitted infections, such as Herpes simplex virus 2, Chlamydia trachomatis and Mycoplasma genitalium and cervical cancer...
June 2018: Journal of Cancer Prevention
https://www.readbyqxmd.com/read/30003067/oral-health-of-korean-patients-with-head-and-neck-cancer
#6
Young-Seok Kim, Yun-Sook Jung, Bo-Kyoung Kim, Eun-Kyong Kim
Background: Association between periodontitis and of head and neck carcinoma was suggested. In the present study, we evaluated the oral health status of patients with head and neck carcinoma and analyzed the relationship between cancer characteristics and oral health. Methods: Oral health of 40 patients with head and neck carcinoma was examined. Decayed teeth, missing teeth, plaque index, gingival index, and probing depth were measured. Cancer type and site were recorded based on the patients' medical records...
June 2018: Journal of Cancer Prevention
https://www.readbyqxmd.com/read/30003066/comparative-analysis-of-ileal-and-cecal-microbiota-in-aged-rats
#7
Sun Min Lee, Nayoung Kim, Ji Hyun Park, Ryoung Hee Nam, Kichul Yoon, Dong Ho Lee
Background: Gut microbiota contributes to intestinal and immune homeostasis through host-microbiota interactions. Distribution of the gut microbiota differs according to the location in the gastrointestinal tract. Although the microbiota properties change with age, evidence for the regional difference of gut microbiota has been restricted to the young. The aim of this study is to compare the gut microbiota between terminal ileum and cecum of old rats. Methods: We analyzed gut microbiome of luminal contents from ileum and cecum of 74-week-old and 2-year-old rats (corresponding to 60-year and 80-year-old of human age) by metagenome sequencing of 16S rRNA...
June 2018: Journal of Cancer Prevention
https://www.readbyqxmd.com/read/30003065/anti-proliferative-effect-of-15-16-dihydrotanshinone-i-through-cell-cycle-arrest-and-the-regulation-of-amp-activated-protein-kinase-akt-mtor-and-mitogen-activated-protein-kinase-signaling-pathway-in-human-hepatocellular-carcinoma-cells
#8
Ji-Young Hong, So Hyun Park, Hyen Joo Park, Sang Kook Lee
Background: 15,16-dihydrotanshinone I (DHTS) is a natural abietane diterpenoid that is mainly found in the roots of Salvia miltiorrhiza Bunge (Labiatae). DHTS exhibits a potential anti-proliferative effect in various human cancer cells. However, the mechanisms of action of DHTS as an anti-cancer agent have not been fully elucidated. Therefore, the present study investigated the anti-cancer effect of DHTS in terms of cell cycle regulation and the regulation of the AMP-activated protein kinase (AMPK)/Akt/mTOR signaling pathway in SK-HEP-1 human hepatocellular carcinoma cells...
June 2018: Journal of Cancer Prevention
https://www.readbyqxmd.com/read/29630064/erratum-novel-genetic-associations-between-lung-cancer-and-indoor-radon-exposure
#9
Jung Ran Choi, Sang-Baek Koh, Seong Yong Park, Hye Ryun Kim, Hyojin Lee, Dae Ryong Kang
[This corrects the article on p. 234 in vol. 22, PMID: 29302581.].
March 2018: Journal of Cancer Prevention
https://www.readbyqxmd.com/read/29629349/knowledge-and-source-of-information-about-early-detection-techniques-of-breast-cancer-among-women-in-iran-a-systematic-review
#10
Salehoddin Bouya, Abbas Balouchi, Sudabeh Ahmadidarehsima, Mahin Badakhsh
Background: An increase of access to knowledge about early detection techniques of breast cancer can reduce this mortality rate. This study aimed to determine the knowledge and source of information about early detection techniques of breast cancer among Iranian women. Methods: Both International (PubMed, Web of Science, and Google Scholar) and national (scientific information database [SID] and Magiran) databases were reviewed launching to September, 2017 to obtain related articles...
March 2018: Journal of Cancer Prevention
https://www.readbyqxmd.com/read/29629348/why-don-t-cancer-survivors-quit-smoking-an-evaluation-of-readiness-for-smoking-cessation-in-cancer-survivors
#11
Melissa A Little, Robert C Klesges, Zoran Bursac, Jon O Ebbert, Jennifer P Halbert, Andrew N Dunkle, Lauren Colvin, Patricia J Goedecke, Benny Weksler
Background: Cancer survivors have a high rate of participation in cigarette-smoking cessation programs but their smoking-abstinence rates remain low. In the current study, we evaluated the readiness to quit smoking in a cancer-survivor population. Methods: Cross-sectional data survey conducted among 112 adult cancer survivors who smoked cigarettes in Tennessee. Analyses were conducted using a two-sample t -test, χ2 test, Fishers Exact test, and multivariable logistic regression with smoker's readiness to quit as the dependent variable...
March 2018: Journal of Cancer Prevention
https://www.readbyqxmd.com/read/29629347/%C3%AE-carotene-inhibits-activation-of-nf-%C3%AE%C2%BAb-activator-protein-1-and-stat3-and-regulates-abnormal-expression-of-some-adipokines-in-3t3-l1-adipocytes
#12
Soon Ok Cho, Min-Hyun Kim, Hyeyoung Kim
Background: Oxidative stress occurs in white adipose tissue and dysregulates the expression of adipokines secreted from adipocytes. Since adipokines influence inflammation, supplementation with antioxidants might be beneficial for preventing oxidative stress-mediated inflammation in adipocytes and inflammation-associated complications. β-Carotene is the most prominent antioxidant carotenoid and scavenges reactive oxygen species in various tissues. The purpose of this study was to determine whether β-carotene regulates the expression of adipokines, such as adiponectin, monocyte chemoattractant protein-1 (MCP-1), and regulated on activation, normal T cell expressed and secreted (RANTES) in 3T3-L1 adipocytes treated with glucose/glucose oxidase (G/GO)...
March 2018: Journal of Cancer Prevention
https://www.readbyqxmd.com/read/29629346/lycopene-protects-against-spontaneous-ovarian-cancer-formation-in-laying-hens
#13
Kazim Sahin, Engin Yenice, Mehmet Tuzcu, Cemal Orhan, Cengizhan Mizrak, Ibrahim H Ozercan, Nurhan Sahin, Bahiddin Yilmaz, Birdal Bilir, Bulent Ozpolat, Omer Kucuk
Background: Dietary intake of lycopene has been associated with a reduced risk of ovarian cancer, suggesting its chemopreventive potential against ovarian carcinogenesis. Lycopene's molecular mechanisms of action in ovarian cancer have not been fully understood. Therefore, in the present study, we investigated the effects of lycopene on the ovarian cancer formation using the laying hen model, a biologically relevant animal model of spontaneous ovarian carcinogenesis due to high incidence rates similar to humans...
March 2018: Journal of Cancer Prevention
https://www.readbyqxmd.com/read/29629345/comparative-effects-of-curcumin-and-tetrahydrocurcumin-on-dextran-sulfate-sodium-induced-colitis-and-inflammatory-signaling-in-mice
#14
Joon-Yeop Yang, Xiancai Zhong, Su-Jung Kim, Do-Hee Kim, Hyun Soo Kim, Jeong-Sang Lee, Hye-Won Yum, Jeewoo Lee, Hye-Kyung Na, Young-Joon Surh
Background: Curcumin, a yellow ingredient of turmeric ( Curcuma longa Linn, Zingiberaceae), has long been used in traditional folk medicine in the management of inflammatory disorders. Although curcumin has been reported to inhibit experimentally-induced colitis and carcinogenesis, the underlying molecular mechanisms remain largely unresolved. Methods: Murine colitis was induced by dextran sulfate sodium (DSS) which mimics inflammatory bowel disease. Curcumin or tetrahydrocurcumin was given orally (0...
March 2018: Journal of Cancer Prevention
https://www.readbyqxmd.com/read/29629344/esculetin-inhibits-the-survival-of-human-prostate-cancer-cells-by-inducing-apoptosis-and-arresting-the-cell-cycle
#15
Kader Turkekul, R Dilsu Colpan, Talha Baykul, Mehmet D Ozdemir, Suat Erdogan
Background: Prostate cancer (PCa) is one of the most important causes of death in men and thus new therapeutic approaches are needed. In this study, antiproliferative and anti-migration properties of a coumarin derivative esculetin were evaluated. Methods: Human PCa cell lines PC3, DU145, and LNCaP were treated with various concentrations of esculetin for 24 to 72 hours, and cell viability was determined by the MTT test. Cell cycle and apoptosis were analyzed by using cell-based cytometer...
March 2018: Journal of Cancer Prevention
https://www.readbyqxmd.com/read/29629343/identification-of-epithelial-mesenchymal-transition-related-target-genes-induced-by-the-mutation-of-smad3-linker-phosphorylation
#16
Sujin Park, Kyung-Min Yang, Yuna Park, Eunji Hong, Chang Pyo Hong, Jinah Park, Kyoungwha Pang, Jihee Lee, Bora Park, Siyoung Lee, Haein An, Mi-Kyung Kwak, Junil Kim, Jin Muk Kang, Pyunggang Kim, Yang Xiao, Guangjun Nie, Akira Ooshima, Seong-Jin Kim
Background: Smad3 linker phosphorylation plays essential roles in tumor progression and metastasis. We have previously reported that the mutation of Smad3 linker phosphorylation sites (Smad3-Erk/Pro-directed kinase site mutant constructs [EPSM]) markedly reduced the tumor progression while increasing the lung metastasis in breast cancer. Methods: We performed high-throughput RNA-Sequencing of the human prostate cancer cell lines infected with adenoviral Smad3-EPSM to identify the genes regulated by Smad3-EPSM...
March 2018: Journal of Cancer Prevention
https://www.readbyqxmd.com/read/29302586/erratum-analysis-of-gastric-body-microbiota-by-pyrosequencing-possible-role-of-bacteria-other-than-helicobacter-pylori-in-the-gastric-carcinogenesis
#17
Sung-Hwa Sohn, Nayoung Kim, Hyun Jin Jo, Jaeyeon Kim, Ji Hyun Park, Ryoung Hee Nam, Yeong-Jae Seok, Yeon-Ran Kim, Dong Ho Lee
[This corrects the article on p. 115 in vol. 22, PMID: 28698866.].
December 2017: Journal of Cancer Prevention
https://www.readbyqxmd.com/read/29302585/high-intensity-interval-training-increases-natural-killer-cell-number-and-function-in-obese-breast-cancer-challenged-mice-and-obese-women
#18
Nicole G Barra, Isabella Y Fan, Jenna B Gillen, Marianne Chew, Katarina Marcinko, Gregory R Steinberg, Martin J Gibala, Ali A Ashkar
High intensity interval training (HIIT) boosts natural killer (NK) cell number and activity in normal weight breast cancer patients; however, whether this occurs in obese individuals is not well established. The goal of this study was to determine whether HIIT effectively boosts NK cells as a therapeutic strategy against breast cancer in an obese mouse model and in overweight/obese women. Diet induced female C57Bl/6 obese mice were assigned to undergo HIIT for four weeks or remain sedentary. Female participants were subjected to a six weeks HIIT protocol...
December 2017: Journal of Cancer Prevention
https://www.readbyqxmd.com/read/29302584/modified-cervicography-and-visual-inspection-with-acetic-acid-as-an-alternative-screening-method-for-cervical-precancerous-lesions
#19
Gatot Purwoto, Hasra Depiesa Dianika, Andre Putra, Sigit Purbadi, Laila Nuranna
Background: We compared the diagnostic accuracy between visual inspection with acetic acid (VIA) and modified cervicography as an alternative screening method for cervical precancerous lesions. Methods: A diagnostic cross-sectional study was performed at the outpatient clinic at an Indonesian national referral hospital from February until April 2015. We collected samples from patients who sequentially underwent VIA examination, modified cervicography, and colposcopy...
December 2017: Journal of Cancer Prevention
https://www.readbyqxmd.com/read/29302583/tp53-r72p-polymorphism-and-susceptibility-to-human-papillomavirus-infection-among-women-with-human-immunodeficiency-virus-in-morocco-a-case-control-study
#20
Ahd Oulad Lahsen, Hanâ Baba, Rajaa Bensghir, Naouar Fayssel, Mustapha Sodqi, Latifa Marih, Sellama Nadifi, Lahcen Wakrim, Kamal Marhoum El Filali, Sayeh Ezzikouri
Background: Human papillomavirus (HPV) is the most common sexually transmitted agent worldwide. HPV is the main causative agent for cervical cancer. The HPV oncoprotein E6 binds to the tumor suppressor gene product p53, promoting its degradation; the Arg allele of TP53 R72P polymorphism binds more ardently with HPV E6 than the Pro variant. Here, we investigated whether TP53 R72P gene variant, rs104252, was associated with susceptibility to HPV infection in women with human immunodeficiency virus (HIV)...
December 2017: Journal of Cancer Prevention
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