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Journal of Cancer Prevention

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https://www.readbyqxmd.com/read/29630064/erratum-novel-genetic-associations-between-lung-cancer-and-indoor-radon-exposure
#1
Jung Ran Choi, Sang-Baek Koh, Seong Yong Park, Hye Ryun Kim, Hyojin Lee, Dae Ryong Kang
[This corrects the article on p. 234 in vol. 22, PMID: 29302581.].
March 2018: Journal of Cancer Prevention
https://www.readbyqxmd.com/read/29629349/knowledge-and-source-of-information-about-early-detection-techniques-of-breast-cancer-among-women-in-iran-a-systematic-review
#2
Salehoddin Bouya, Abbas Balouchi, Sudabeh Ahmadidarehsima, Mahin Badakhsh
Background: An increase of access to knowledge about early detection techniques of breast cancer can reduce this mortality rate. This study aimed to determine the knowledge and source of information about early detection techniques of breast cancer among Iranian women. Methods: Both International (PubMed, Web of Science, and Google Scholar) and national (scientific information database [SID] and Magiran) databases were reviewed launching to September, 2017 to obtain related articles...
March 2018: Journal of Cancer Prevention
https://www.readbyqxmd.com/read/29629348/why-don-t-cancer-survivors-quit-smoking-an-evaluation-of-readiness-for-smoking-cessation-in-cancer-survivors
#3
Melissa A Little, Robert C Klesges, Zoran Bursac, Jon O Ebbert, Jennifer P Halbert, Andrew N Dunkle, Lauren Colvin, Patricia J Goedecke, Benny Weksler
Background: Cancer survivors have a high rate of participation in cigarette-smoking cessation programs but their smoking-abstinence rates remain low. In the current study, we evaluated the readiness to quit smoking in a cancer-survivor population. Methods: Cross-sectional data survey conducted among 112 adult cancer survivors who smoked cigarettes in Tennessee. Analyses were conducted using a two-sample t -test, χ2 test, Fishers Exact test, and multivariable logistic regression with smoker's readiness to quit as the dependent variable...
March 2018: Journal of Cancer Prevention
https://www.readbyqxmd.com/read/29629347/%C3%AE-carotene-inhibits-activation-of-nf-%C3%AE%C2%BAb-activator-protein-1-and-stat3-and-regulates-abnormal-expression-of-some-adipokines-in-3t3-l1-adipocytes
#4
Soon Ok Cho, Min-Hyun Kim, Hyeyoung Kim
Background: Oxidative stress occurs in white adipose tissue and dysregulates the expression of adipokines secreted from adipocytes. Since adipokines influence inflammation, supplementation with antioxidants might be beneficial for preventing oxidative stress-mediated inflammation in adipocytes and inflammation-associated complications. β-Carotene is the most prominent antioxidant carotenoid and scavenges reactive oxygen species in various tissues. The purpose of this study was to determine whether β-carotene regulates the expression of adipokines, such as adiponectin, monocyte chemoattractant protein-1 (MCP-1), and regulated on activation, normal T cell expressed and secreted (RANTES) in 3T3-L1 adipocytes treated with glucose/glucose oxidase (G/GO)...
March 2018: Journal of Cancer Prevention
https://www.readbyqxmd.com/read/29629346/lycopene-protects-against-spontaneous-ovarian-cancer-formation-in-laying-hens
#5
Kazim Sahin, Engin Yenice, Mehmet Tuzcu, Cemal Orhan, Cengizhan Mizrak, Ibrahim H Ozercan, Nurhan Sahin, Bahiddin Yilmaz, Birdal Bilir, Bulent Ozpolat, Omer Kucuk
Background: Dietary intake of lycopene has been associated with a reduced risk of ovarian cancer, suggesting its chemopreventive potential against ovarian carcinogenesis. Lycopene's molecular mechanisms of action in ovarian cancer have not been fully understood. Therefore, in the present study, we investigated the effects of lycopene on the ovarian cancer formation using the laying hen model, a biologically relevant animal model of spontaneous ovarian carcinogenesis due to high incidence rates similar to humans...
March 2018: Journal of Cancer Prevention
https://www.readbyqxmd.com/read/29629345/comparative-effects-of-curcumin-and-tetrahydrocurcumin-on-dextran-sulfate-sodium-induced-colitis-and-inflammatory-signaling-in-mice
#6
Joon-Yeop Yang, Xiancai Zhong, Su-Jung Kim, Do-Hee Kim, Hyun Soo Kim, Jeong-Sang Lee, Hye-Won Yum, Jeewoo Lee, Hye-Kyung Na, Young-Joon Surh
Background: Curcumin, a yellow ingredient of turmeric ( Curcuma longa Linn, Zingiberaceae), has long been used in traditional folk medicine in the management of inflammatory disorders. Although curcumin has been reported to inhibit experimentally-induced colitis and carcinogenesis, the underlying molecular mechanisms remain largely unresolved. Methods: Murine colitis was induced by dextran sulfate sodium (DSS) which mimics inflammatory bowel disease. Curcumin or tetrahydrocurcumin was given orally (0...
March 2018: Journal of Cancer Prevention
https://www.readbyqxmd.com/read/29629344/esculetin-inhibits-the-survival-of-human-prostate-cancer-cells-by-inducing-apoptosis-and-arresting-the-cell-cycle
#7
Kader Turkekul, R Dilsu Colpan, Talha Baykul, Mehmet D Ozdemir, Suat Erdogan
Background: Prostate cancer (PCa) is one of the most important causes of death in men and thus new therapeutic approaches are needed. In this study, antiproliferative and anti-migration properties of a coumarin derivative esculetin were evaluated. Methods: Human PCa cell lines PC3, DU145, and LNCaP were treated with various concentrations of esculetin for 24 to 72 hours, and cell viability was determined by the MTT test. Cell cycle and apoptosis were analyzed by using cell-based cytometer...
March 2018: Journal of Cancer Prevention
https://www.readbyqxmd.com/read/29629343/identification-of-epithelial-mesenchymal-transition-related-target-genes-induced-by-the-mutation-of-smad3-linker-phosphorylation
#8
Sujin Park, Kyung-Min Yang, Yuna Park, Eunji Hong, Chang Pyo Hong, Jinah Park, Kyoungwha Pang, Jihee Lee, Bora Park, Siyoung Lee, Haein An, Mi-Kyung Kwak, Junil Kim, Jin Muk Kang, Pyunggang Kim, Yang Xiao, Guangjun Nie, Akira Ooshima, Seong-Jin Kim
Background: Smad3 linker phosphorylation plays essential roles in tumor progression and metastasis. We have previously reported that the mutation of Smad3 linker phosphorylation sites (Smad3-Erk/Pro-directed kinase site mutant constructs [EPSM]) markedly reduced the tumor progression while increasing the lung metastasis in breast cancer. Methods: We performed high-throughput RNA-Sequencing of the human prostate cancer cell lines infected with adenoviral Smad3-EPSM to identify the genes regulated by Smad3-EPSM...
March 2018: Journal of Cancer Prevention
https://www.readbyqxmd.com/read/29302586/erratum-analysis-of-gastric-body-microbiota-by-pyrosequencing-possible-role-of-bacteria-other-than-helicobacter-pylori-in-the-gastric-carcinogenesis
#9
Sung-Hwa Sohn, Nayoung Kim, Hyun Jin Jo, Jaeyeon Kim, Ji Hyun Park, Ryoung Hee Nam, Yeong-Jae Seok, Yeon-Ran Kim, Dong Ho Lee
[This corrects the article on p. 115 in vol. 22, PMID: 28698866.].
December 2017: Journal of Cancer Prevention
https://www.readbyqxmd.com/read/29302585/high-intensity-interval-training-increases-natural-killer-cell-number-and-function-in-obese-breast-cancer-challenged-mice-and-obese-women
#10
Nicole G Barra, Isabella Y Fan, Jenna B Gillen, Marianne Chew, Katarina Marcinko, Gregory R Steinberg, Martin J Gibala, Ali A Ashkar
High intensity interval training (HIIT) boosts natural killer (NK) cell number and activity in normal weight breast cancer patients; however, whether this occurs in obese individuals is not well established. The goal of this study was to determine whether HIIT effectively boosts NK cells as a therapeutic strategy against breast cancer in an obese mouse model and in overweight/obese women. Diet induced female C57Bl/6 obese mice were assigned to undergo HIIT for four weeks or remain sedentary. Female participants were subjected to a six weeks HIIT protocol...
December 2017: Journal of Cancer Prevention
https://www.readbyqxmd.com/read/29302584/modified-cervicography-and-visual-inspection-with-acetic-acid-as-an-alternative-screening-method-for-cervical-precancerous-lesions
#11
Gatot Purwoto, Hasra Depiesa Dianika, Andre Putra, Sigit Purbadi, Laila Nuranna
Background: We compared the diagnostic accuracy between visual inspection with acetic acid (VIA) and modified cervicography as an alternative screening method for cervical precancerous lesions. Methods: A diagnostic cross-sectional study was performed at the outpatient clinic at an Indonesian national referral hospital from February until April 2015. We collected samples from patients who sequentially underwent VIA examination, modified cervicography, and colposcopy...
December 2017: Journal of Cancer Prevention
https://www.readbyqxmd.com/read/29302583/tp53-r72p-polymorphism-and-susceptibility-to-human-papillomavirus-infection-among-women-with-human-immunodeficiency-virus-in-morocco-a-case-control-study
#12
Ahd Oulad Lahsen, Hanâ Baba, Rajaa Bensghir, Naouar Fayssel, Mustapha Sodqi, Latifa Marih, Sellama Nadifi, Lahcen Wakrim, Kamal Marhoum El Filali, Sayeh Ezzikouri
Background: Human papillomavirus (HPV) is the most common sexually transmitted agent worldwide. HPV is the main causative agent for cervical cancer. The HPV oncoprotein E6 binds to the tumor suppressor gene product p53, promoting its degradation; the Arg allele of TP53 R72P polymorphism binds more ardently with HPV E6 than the Pro variant. Here, we investigated whether TP53 R72P gene variant, rs104252, was associated with susceptibility to HPV infection in women with human immunodeficiency virus (HIV)...
December 2017: Journal of Cancer Prevention
https://www.readbyqxmd.com/read/29302582/secondary-primary-prostate-cancer-after-colorectal-cancer-a-nationwide-population-based-cohort-study-in-korea
#13
Hyun Soo Kim, Yoon Jin Choi, Dong Woo Shin, Kyung-Do Han, Hyuk Yoon, Cheol Min Shin, Young Soo Park, Nayoung Kim, Dong Ho Lee
Background: Colorectal cancer (CRC) and prostate cancer frequently occur in developed countries. There are several reports on the association between CRC and prostate cancer; however, the conclusions are inconsistent to investigate the association of the development of secondary primary prostate cancer among patients with prior primary CRC using a nationwide population-based dataset. Methods: Patients registered in the Republic of Korea National Health Insurance System database who were diagnosed with CRC between 2007 and 2012 were followed-up until the end of 2015, and we investigated the new diagnosis secondary primary prostate cancer...
December 2017: Journal of Cancer Prevention
https://www.readbyqxmd.com/read/29302581/novel-genetic-associations-between-lung-cancer-and-indoor-radon-exposure
#14
Jung Ran Choi, Sang-Baek Koh, Seong Yong Park, Hye Run Kim, Hyojin Lee, Dae Ryong Kang
Background: Lung cancer is the leading cause of cancer-related death worldwide, for which smoking is considered as the primary risk factor. The present study was conducted to determine whether genetic alterations induced by radon exposure are associated with the susceptible risk of lung cancer in never smokers. Methods: To accurately identify mutations within individual tumors, next generation sequencing was conduct for 19 pairs of lung cancer tissue. The associations of germline and somatic variations with radon exposure were visualized using OncoPrint and heatmap graphs...
December 2017: Journal of Cancer Prevention
https://www.readbyqxmd.com/read/29302580/protective-effect-of-allium-tuberosum-extract-on-vascular-inflammation-in-tumor-necrosis-factor-%C3%AE-induced-human-vascular-endothelial-cells
#15
Haeng Jeon Hur, Ae Sin Lee
Background: Endothelial adhesion molecule expression induced by pro-inflammatory cytokine plays an important role in vascular endothelial cell injury, leading to vascular disease. Allium tuberosum (AT), which is used as a functional food, has a thrombolytic effect. It contains vitamin A, vitamin C, carbohydrate, calcium, iron, and phosphorus. There are many carotenes that turn into vitamin A in the body. Also, it helps blood circulation and stimulates metabolism. The purpose of the this study was to estimate the anti-inflammatory effects of the AT extract...
December 2017: Journal of Cancer Prevention
https://www.readbyqxmd.com/read/29302579/myricetin-inhibits-angiogenesis-by-inducing-apoptosis-and-suppressing-pi3k-akt-mtor-signaling-in-endothelial-cells
#16
Gi Dae Kim
Background: Myricetin has been shown to possess potential antiangiogenic effects in endothelial cells. However, the underlying mechanisms are not fully understood. Therefore, we evaluated its antiangiogenic effects in human umbilical vascular endothelial cells (HUVECs). Methods: HUVECs were cultured in endothelial cell growth medium-2 to induce proliferation and angiogenesis and treated with different doses of myricetin (0.25, 0.5, and 1 μM) for 24 hours. Cell proliferation was analyzed by the MTT and lactate dehydrogenase release assays; angiogenesis was determined by the tube formation assay...
December 2017: Journal of Cancer Prevention
https://www.readbyqxmd.com/read/29302578/epigenomic-hard-drive-imprinting-a-hidden-code-beyond-the-biological-death-of-cancer-patients
#17
REVIEW
Pritish Nilendu, Nilesh Kumar Sharma
Several genetic and epigenetic theories have been suggested to explain the intricacies of life and death. However, several questions remain unsettled regarding cellular death events, particularly of living tissue in the case of cancer patients, such as the fate and adaptation of cancer cells after biological death. It is possible that cancer cells can display the intent to communicate with the external environment after biological death by means of molecular, genetic, and epigenetic pathways. Whether these cancer cells contain special information in the form of coding that may help them survive beyond the biological death of cancer patients is unknown...
December 2017: Journal of Cancer Prevention
https://www.readbyqxmd.com/read/29302577/rna-binding-protein-as-an-emerging-therapeutic-target-for-cancer-prevention-and-treatment
#18
REVIEW
Suntaek Hong
After transcription, RNAs are always associated with RNA binding proteins (RBPs) to perform biological activities. RBPs can interact with target RNAs in sequence- and structure-dependent manner through their unique RNA binding domains. In development and progression of carcinogenesis, RBPs are aberrantly dysregulated in many human cancers with various mechanisms, such as genetic alteration, epigenetic change, noncoding RNA-mediated regulation, and post-translational modifications. Upon deregulation in cancers, RBPs influence every step in the development and progression of cancer, including sustained cell proliferation, evasion of apoptosis, avoiding immune surveillance, inducing angiogenesis, and activating metastasis...
December 2017: Journal of Cancer Prevention
https://www.readbyqxmd.com/read/29018785/regulation-of-inflammation-by-sucrose-isomer-turanose-in-raw-264-7-cells
#19
Joo-Yeon Chung, Yoo-Sun Kim, Yuri Kim, Sang-Ho Yoo
Increased sugar consumption has been proposed to be a risk factor for obesity-related metabolic disorders. The objective of this study was to investigate the anti-inflammatory effect of turanose in Raw 264.7 macrophages. Turanose (3-O-α-D-glucosyl-D-fructose), an isomer of sucrose, naturally exists in honey. For these studies, macrophages were treated with total glucose (Glu), 50% Glu/50% turanose (T50), 25% Glu/75% turanose (T75), and 100% turanose (T100), each with a total concentration of 25 mM in cell media...
September 2017: Journal of Cancer Prevention
https://www.readbyqxmd.com/read/29018784/peroxisome-proliferator-activated-receptor-gamma-inhibits-the-activation-of-stat3-in-cerulein-stimulated-pancreatic-acinar-cells
#20
Kyung Don Ju, Joo Weon Lim, Hyeyoung Kim
Cerulein-induced pancreatitis is similar to human edematous pancreatitis, characterized by the dysregulation of digestive enzyme production, edema formation, and an infiltration of inflammatory cells into the pancreas. We previously showed that the Janus kinase 2 (JAK2)/STAT3 pathway mediates inflammatory signaling in cerulein-stimulated pancreatic acinar cells. PPAR-γ has been implicated in the regulation of inflammatory responses in several cells. In the present study, we investigated the role of PPAR-γ in cerulein-induced activation of JAK2/STAT3 in pancreatic acinar cells...
September 2017: Journal of Cancer Prevention
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