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BioMedicine

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https://www.readbyqxmd.com/read/29130451/population-based-cohort-study-investigating-the-association-between-weight-loss-and-pyogenic-liver-abscesses
#1
Shih-Wei Lai, Cheng-Li Lin, Kuan-Fu Liao
BACKGROUND AND AIM: Few systematic studies focus on the association between weight loss and pyogenic liver abscesses. The objective of the study was to assess the association between weight loss and pyogenic liver abscesses in adults in Taiwan. METHODS: This population-based cohort study utilized the database of the Taiwan National Health Insurance Program. Totally, 8453 subjects aged 20 to 84 years with newly diagnosed weight loss between 2000 and 2012 were assigned as the weight loss group, and 33777 randomly selected subjects without weight loss were assigned as the non-weight loss group...
December 2017: BioMedicine
https://www.readbyqxmd.com/read/29130450/lower-risk-of-end-stage-renal-disease-in-diabetic-nurse
#2
Cheng-Chin Pan, Hsiu-Ling Huang, Ming-Chih Chen, Chuan-Yu Kung, Pei-Tseng Kung, Wen-Yu Chou, Wen-Chen Tsai
OBJECTIVES: As professional medical caregivers, nurses have extensive medical knowledge and information than general population. However, they may use their professional knowledge and networks to seek prompt health services. In this study, we aimed to determine susceptibility of nurses with diabetes to developing end-stage renal disease requiring dialysis compared to diabetes patients in the general population. METHODS: This retrospective longitudinal study extracted data of nurses with newly diagnosed diabetes and general patients with diabetes from the National Health Insurance Database between 1998 and 2006 and follow-up to December 2009, satisfied the participant inclusion criteria was 518,058...
December 2017: BioMedicine
https://www.readbyqxmd.com/read/29130449/the-antioxidant-activity-and-nitric-oxide-production-of-extracts-obtained-from-the-leaves-of-chenopodium-quinoa-willd
#3
Hsiao-Ling Chen, Xiang-Zhen Lan, Yan-Yi Wu, Yu-Wen Ou, Tsung Chi Chen, Wen-Tzu Wu
BACKGROUND: Most reports have indicated the antioxidant capacity of quinoa seeds. However, the leaves of Quinoa (Chenopodium quinoa Willd.) are usually worthless and little known about their biological activities. In this study, the antioxidant and immunomodulatory potential of the quinoa leaf extracts were explored. METHODS: The crude leaf extracts of quinoa were extracted using water, 50% ethanol or 95% ethanol as solvent, denoted WQL, 50% EQL and 95% EQL, respectively...
December 2017: BioMedicine
https://www.readbyqxmd.com/read/29130448/a-review-on-the-effects-of-current-chemotherapy-drugs-and-natural-agents-in-treating-non-small-cell-lung-cancer
#4
Chih-Yang Huang, Da-Tong Ju, Chih-Fen Chang, P Muralidhar Reddy, Bharath Kumar Velmurugan
Lung cancer is the leading cause of cancer deaths worldwide, and this makes it an attractive disease to review and possibly improve therapeutic treatment options. Surgery, radiation, chemotherapy, targeted treatments, and immunotherapy separate or in combination are commonly used to treat lung cancer. However, these treatment types may cause different side effects, and chemotherapy-based regimens appear to have reached a therapeutic plateau. Hence, effective, better-tolerated treatments are needed to address and hopefully overcome this conundrum...
December 2017: BioMedicine
https://www.readbyqxmd.com/read/29130447/only-lasers-can-be-used-for-low-level-laser-therapy
#5
Sergey Vladimirovich Moskvin
The question of lasers' exclusivity, as well as the degree of influence of special properties of low-intensity laser illumination (LILI), such as coherence, polarity and monochromaticity, on the effectiveness of low level laser therapy (LLLT) continues to cause arguments. The study analyzes publications from 1973 to 2016, in which laser and conventional light sources are compared, and the following conclusions are drawn. First, there are a lot of publications with incorrect comparison or unfounded statements...
December 2017: BioMedicine
https://www.readbyqxmd.com/read/29130446/the-role-of-mucin-educated-platelet-activation-in-tumor-invasiveness-an-unfolding-concern-in-the-realm-of-cancer-biology
#6
EDITORIAL
Akbar Shoukat Ali, Arzoo Ajaz
Metastasis is a complex and well-coordinated phenotypic transformation of cancer cells governed by aberrant genetic and molecular pathways. It has been approved as the most consistent cause of cancer death. With emerging insight into the genomics, transcriptomics and proteomics, progress has been made and reasonably large number of molecular pathways of metastasis has been forwarded, but our understanding of precise underlying molecular mechanisms remains largely scarce. It has been well-known for around a decade and more that platelets are intriguingly contributing to the cancer metastasis...
December 2017: BioMedicine
https://www.readbyqxmd.com/read/28840834/risk-of-contracting-pneumonia-among-patients-with-predialysis-chronic-kidney-disease-a-population-based-cohort-study-in-taiwan
#7
Shih-Wei Lai, Cheng-Li Lin, Kuan-Fu Liao
OBJECTIVES: The objective of the study was to investigate the association between predialysis chronic kidney disease and contracting pneumonia in Taiwan. METHODS: We employed a population-based, retrospective cohort design using the database of the Taiwan National Health Insurance (NHI) Program. There were 18807 subjects aged 20-84 years who were newly diagnosed with predialysis chronic kidney disease between 2000 to 2012 as the predialysis chronic kidney disease group and 18807 randomly selected subjects without chronic kidney disease as the non-chronic kidney disease group...
September 2017: BioMedicine
https://www.readbyqxmd.com/read/28840833/the-anti-inflammatory-and-anti-glycative-effects-of-rosmarinic-acid-in-the-livers-of-type-1-diabetic-mice
#8
Yu-Ju Wen, Mei-Chin Yin
BACKGROUND: Rosmarinic acid (RA) is a polyphenol present in members of the Lamiaceae family. In this study, yhe anti-inflammatory and anti-glycative effects of RA in the livers of type 1 diabetic mice were examined. METHODS: The diabetic mice were divided into three groups: diabetic mice with 0, low dose RA (25 mg/ml), and high dose RA (50 mg/ml). One group of non-diabetic mice was used as a control for comparison. RA was supplied via daily 200 μL oral injections for 9 weeks...
September 2017: BioMedicine
https://www.readbyqxmd.com/read/28840832/torenia-concolor-lindley-var-formosana-yamazaki-extracts-improve-inflammatory-response-and-lipid-accumulation-via-ppars-activation
#9
Yu-Chia Liang, Jun-Cheng Hu, Pei-Ying Li, Guan-Jhong Huang, Yueh-Hsiung Kuo, Che-Yi Chao
Background/Introduction: At present, human diet is replete with sugar and fat. Abnormal metabolism and hyperglycemia or hyperlipidemia in the body induces the development of an overactive and continuous inflammatory response, resulting in obesity and metabolic syndromes, including hypertension, hyperlipidemia, and insulin resistance. Torenia concolor Lindley var. formosana Yamazaki (TC), a perennial creeping herbaceous plant, is a traditional Chinese medicinal herb widely used for the treatment of heat stroke, aching muscles and bones, cold, dysentery, and ambustion...
September 2017: BioMedicine
https://www.readbyqxmd.com/read/28840831/fluvastatin-use-and-risk-of-acute-pancreatitis-a-population-based-case-control-study-in-taiwan
#10
Kuan-Fu Liao, Po-Tsung Huang, Ching-Chun Lin, Cheng-Li Lin, Shih-Wei Lai
OBJECTIVES: This study aimed to examine the association between fluvastatin use and acute pancreatitis in Taiwan. METHODS: Using the database from the Taiwan National Health Insurance (NHI) Program, we designed a case-control study which consisted of 3501 individuals aged 20-84 with new at-the-time diagnoses acute pancreatitis as the case group and 8373 randomly selected individuals without acute pancreatitis as the control group during the period of 1998-2011. Both groups were matched for sex, age, and index year of being diagnosed with acute pancreatitis...
September 2017: BioMedicine
https://www.readbyqxmd.com/read/28840830/mesh-materials-and-hernia-repair
#11
Santhini Elango, Sakthivel Perumalsamy, Krishnakumar Ramachandran, Ketankumar Vadodaria
Hernia incidence has been observed since ancient time. Advancement in the medical textile industry came up with the variety of mesh materials to repair hernia, but none of them are without complications including recurrence of hernia. Therefore individuals once developed with the hernia could not lead a healthy and comfortable life. This drawn attention of surgeons, patients, researchers and industry to know the exact mechanism behind its development, complications and recurrence. Recent investigations highlighted the role of genetic factors and connective tissue disorders being the reason for the development of hernia apart from the abnormal pressure that is known to develop during other disease conditions...
September 2017: BioMedicine
https://www.readbyqxmd.com/read/28840829/transglutaminase-2-in-human-diseases
#12
Zsuzsa Szondy, Ilma Korponay-Szabó, Robert Király, Zsolt Sarang, Gregory J Tsay
Transglutaminase 2 (TG2) is an inducible transamidating acyltransferase that catalyzes Ca(2+)-dependent protein modifications. In addition to being an enzyme, TG2 also serves as a G protein for several seven transmembrane receptors and acts as a co-receptor for integrin β1 and β3 integrins distinguishing it from other members of the transglutaminase family. TG2 is ubiquitously expressed in almost all cell types and all cell compartments, and is also present on the cell surface and gets secreted to the extracellular matrix via non-classical mechanisms...
September 2017: BioMedicine
https://www.readbyqxmd.com/read/28612712/subcutaneous-injection-induced-cellulites
#13
Kao-Chi Cheng, Po-Tsung Huang, Chiu-Shong Liu, Wen-Yuan Lin
In the hospice ward where patients are in the terminal stages of cancer, it is common practice to give them a subcutaneous injection of pain relievers to reduce their pain and make them more comfortable. Most of these patients are elderly and have low blood pressure or poor veins, which often makes it difficult to inject them because of the calcification at previous injection sites. Thus, subcutaneous injections are a convenient way to maintain analgesia and patient comfort. Our patient, a 73-year-old aboriginal woman, was diagnosed with gastric adenocarcinoma and peritoneal carcinomatosis in March, 2004...
June 2017: BioMedicine
https://www.readbyqxmd.com/read/28612711/alleviative-effects-from-boswellic-acid-on-acetaminophen-induced-hepatic-injury-corrected-and-republished-from-biomedicine-taipei-2016-jun-6-2-9-doi-10-7603-s40681-016-0009-1pmcid-pmc4864770
#14
Lung-Che Chen, Li-Hong Hu, Mei-Chin Yin
Protective effects of boswellic acid (BA) against acetaminophen (APAP)-induced hepatotoxicity in Balb/ cA mice were examined. BA, at 0.05 or 0.1%, was supplied for 4 weeks. Acute liver injury was induced by APAP treatment. Results showed that BA intake increased hepatic BA bioavailability. APAP treatment decreased glutathione (GSH) level, increased reactive oxygen species (ROS) and oxidized glutathione (GSSG) production; and lowered activity and protein expression of glutathione reductase (GR) and heme oxygenase (HO)-1 in liver...
June 2017: BioMedicine
https://www.readbyqxmd.com/read/28612710/yc-1-induces-g0-g1-phase-arrest-and-mitochondria-dependent-apoptosis-in-cisplatin-resistant-human-oral-cancer-car-cells
#15
Miau-Rong Lee, Chingju Lin, Chi-Cheng Lu, Sheng-Chu Kuo, Je-Wei Tsao, Yu-Ning Juan, Hong-Yi Chiu, Fang-Yu Lee, Jai-Sing Yang, Fuu-Jen Tsai
Oral cancer is a serious and fatal disease. Cisplatin is the first line of chemotherapeutic agent for oral cancer therapy. However, the development of drug resistance and severe side effects cause tremendous problems clinically. In this study, we investigated the pharmacologic mechanisms of YC-1 on cisplatin-resistant human oral cancer cell line, CAR. Our results indicated that YC-1 induced a concentration-dependent and time-dependent decrease in viability of CAR cells analyzed by MTT assay. Real-time image analysis of CAR cells by IncuCyte™ Kinetic Live Cell Imaging System demonstrated that YC-1 inhibited cell proliferation and reduced cell confluence in a time-dependent manner...
June 2017: BioMedicine
https://www.readbyqxmd.com/read/28612709/potential-phytoestrogen-alternatives-exert-cardio-protective-mechanisms-via-estrogen-receptors
#16
Marthandam Asokan Shibu, Wei-Wen Kuo, Chia-Hua Kuo, Cecilia-Hsuan Day, Chia-Yao Shen, Li-Chin Chung, Chao-Hung Lai, Lung-Fa Pan, V Vijaya Padma, Chih-Yang Huang
The 17 beta-estradiol (E2) is a sex hormone that is most abundant and most active estrogen in premenopausal women. The importance of E2 in providing cardioprotection and reducing the occurrence of heart disease in women of reproductive age has been well recognized. There are three subtype of estrogen receptors (ERs), including ERα, ERβ and GPR30 have been identified and accumulating evidence reveal their roles on E2-mediated genomic and nongenomic pathway in cardiomyocytes against various cardiac insults...
June 2017: BioMedicine
https://www.readbyqxmd.com/read/28612708/contribution-of-matrix-metalloproteinases-1-genotypes-to-gastric-cancer-susceptibility-in-taiwan
#17
Mei-Due Yang, Kuo-Cheng Lin, Meng-Chun Lu, Long-Bin Jeng, Chieh-Lun Hsiao, Te-Cheng Yueh, Chun-Kai Fu, Hsin-Ting Li, Shiou-Ting Yen, Chia-Wen Lin, Cin-Wun Wu, Su-Yi Pang, Da-Tian Bau, Fuu-Jen Tsai
Expression of matrix metalloproteinase-1 (MMP1), an interstitial collagenase regulating the extracellular matrix, plays a major role in carcinogenesis of gastric cancer, a leading cause of death worldwide. In literature, the single-nucleotide polymorphism (SNP) promoter -1607 1G/2G (rs1799750) at the MMP1 gene promoter has been reported to alter its own transcription level. While the importance's of the genotype of MMP1 promoter -1607 has not yet been studied in gastric cancer in Taiwan, our aim was to investigate MMP1 promoter -1607 genotypes and gastric cancer (GC) susceptibility in central Taiwan population...
June 2017: BioMedicine
https://www.readbyqxmd.com/read/28612707/genetic-characteristic-of-class-1-integrons-in-proteus-mirabilis-isolates-from-urine-samples
#18
Chih-Ming Chen, Chih-Ho Lai, Hwa-Jene Wu, Lii-Tzu Wu
BACKGROUND: Proteus mirabilis is an opportunistic pathogen, commonly associated with complicated urinary tract infections (UTIs). UTIs caused by multidrug-resistant Proteus mirabilis have increased worldwide. Multidrug-resistance of Gram-negative enteric bacteria is usually associated with class 1 integrons. PURPOSES: To investigate the prevalence and characterize gene cassettes of class 1 integrons in multidrug-resistant P. mirabilis Methods: From 2006 to 2008, 314 P...
June 2017: BioMedicine
https://www.readbyqxmd.com/read/28612706/autophagy-and-its-link-to-type-ii-diabetes-mellitus
#19
Jai-Sing Yang, Chi-Cheng Lu, Sheng-Chu Kuo, Yuan-Man Hsu, Shih-Chang Tsai, Shih-Yin Chen, Yng-Tay Chen, Ying-Ju Lin, Yu-Chuen Huang, Chao-Jung Chen, Wei-De Lin, Wen-Lin Liao, Wei-Yong Lin, Yu-Huei Liu, Jinn-Chyuan Sheu, Fuu-Jen Tsai
Autophagy, a double-edged sword for cell survival, is the research object on 2016 Nobel Prize in Physiology or Medicine. Autophagy is a molecular mechanism for maintaining cellular physiology and promoting survival. Defects in autophagy lead to the etiology of many diseases, including diabetes mellitus (DM), cancer, neurodegeneration, infection disease and aging. DM is a metabolic and chronic disorder and has a higher prevalence in the world as well as in Taiwan. The character of diabetes mellitus is hyperglycemia resulting from defects in insulin secretion, insulin action, or both...
June 2017: BioMedicine
https://www.readbyqxmd.com/read/28474583/correction-notice-to-alleviative-effects-from-boswellic-acid-on-acetaminophen-induced-hepatic-injury-biomedicine-taipei-2016-jun-6-2-9-doi-10-7603-s40681-016-0009-1
#20
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