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Journal of Frailty & Aging

I Baiges, L Arola
BACKGROUND: Saccharomyces cerevisiae is a model organism with conserved aging pathways. Yeast chronological lifespan experiments mimic the processes involved in human non-dividing tissues, such as the nervous system or skeletal muscle, and can speed up the search for biomolecules with potential anti-aging effects before proceeding to animal studies. OBJECTIVE: To test the effectiveness of a cocoa polyphenol-rich extract (CPE) in expanding the S. cerevisiae chronological lifespan in two conditions: in the stationary phase reached after glucose depletion and under severe caloric restriction...
2016: Journal of Frailty & Aging
L Letrilliart, S Oustric
No abstract text is available yet for this article.
2016: Journal of Frailty & Aging
H-S Lin, N M Peel, R E Hubbard
This study aimed to derive measures of baseline vulnerability and inpatient frailty in elderly surgical patients and to study their association with adverse post-operative outcomes. Data from comprehensive geriatric assessment of 208 general surgical and orthopaedic patients aged 70 and over admitted to four acute hospitals in Queensland, Australia, were analysed to derive a baseline and inpatient Frailty Index (FI). The association of these indices with adverse outcomes was examined in logistic regression...
2016: Journal of Frailty & Aging
M A McAdams-DeMarco, H Ying, I Olorundare, E A King, N Desai, N Dagher, B Lonze, R Montgomery, J Walston, D L Segev
BACKGROUND: Frailty is associated with worse health-related quality of life (HRQOL) in older adults and worse clinical outcomes in adults of all ages with end stage renal disease (ESRD). It is unclear whether frail adults of all ages with ESRD are more likely to experience worse HRQOL. OBJECTIVE: The goal of this study was to identify factors associated with worsening HRQOL in this population. Design, setting and measurements: We studied 233 adults of all ages with ESRD enrolled (11/2009-11/2013) in a longitudinal cohort study...
2016: Journal of Frailty & Aging
B Bongue, A Colvez, E Amsallem, L Gerbaud, C Sass
BACKGROUND: Most of the indicators commonly used to assess social deprivation are poorly suited to study health inequalities in older people. The EPICES (Evaluation of Deprivation and Inequalities in Health Examination Centres) score is a new composite index commonly used to measure individual deprivation. OBJECTIVE: To assess the relationships between health indicators and the EPICES score in older people. DESIGN, SETTING, AND PARTICIPANTS: We performed a cross-sectional study using the data from the 2008 ESPS Survey (Health, HealthCare and Insurance Survey)...
2016: Journal of Frailty & Aging
A H Abdelhafiz, L Koay, A J Sinclair
Ageing is associated with hyperglycaemic tendency due to the change in body composition leading to accumulation of visceral fat and increased insulin resistance on the one hand and reduced insulin secretion due to decreased number and function of the β-cells of the pancreas on the other. However, with the emergence of frailty there may be a tendency towards normoglycaemia or even hypoglycaemia due to malnutrition, weight loss and reduced physiologic reserve. This shift in glucose metabolism induced by frailty may change the natural history of type 2 diabetes from a progressive to a regressive course...
2016: Journal of Frailty & Aging
C S Chan, S E Slaughter, C A Jones, A S Wagg
Few studies have measured the activity patterns of continuing care residents using objective, uniaxial, accelerometers such as the activPAL. This exploratory study described the activity performance of continuing care residents and explored the correlation of activity performance with grip strength, falls and mobility. Data were gathered from 24 continuing care residents. Participants (82.3 ± 5.8 years of age), wore the activPAL an average of 12.60 hours per day (SD = 0.96) and were stepping for a median of 0...
2016: Journal of Frailty & Aging
A P Greenfield, S Banerjee, A DePasquale, N Weiss, J Sirey
OBJECTIVES: This study used the Evans model of public health determinants to identify factors associated with nutritional risk in older adults. DESIGN: The Evans model domains (physical and mental well-being, social/environmental statuses, individual choice, and economic security) were measured in a sample of homebound older adults. Regularized logistic regression analysis with LASSO penalty function was used to determine the strongest domain of the Evans model...
2016: Journal of Frailty & Aging
E Luger, S Haider, A Kapan, K Schindler, C Lackinger, T E Dorner
BACKGROUND: For developed countries, healthy aging is one of the challenges and the number of healthy life years and especially the quality of life (QoL) are important. OBJECTIVE: This study aimed to assess the association between nutritional status and different domains of QoL in (pre)frail community-dwelling elders. DESIGN: Baseline data from persons, who participated in a 12-week nutritional and physical training intervention program, conducted from September 2013 - July 2015...
2016: Journal of Frailty & Aging
F Cerreta, J Ankri, D Bowen, A Cherubini, A J Cruz Jentoft, A Guðmundsson, M Haberkamp, P Jansen, N Marchionni, S Morgan, E Rönnemaa, M Petrovic, A Pilotto, M Rosa, H Wildiers
No abstract text is available yet for this article.
2016: Journal of Frailty & Aging
J Collins, G Longhurst, H Roschel, B Gualano
BACKGROUND: Studies assessing the effects co-supplementation with creatine and protein, along with resistance training, in older individuals with frailty are lacking. OBJECTIVES: This is an exploratory trial from the Pro-Elderly study ("Protein Intake and Resistance Training in Aging") aimed at gathering knowledge on the feasibility, safety, and efficacy of co-supplementation with creatine and protein supplementation, combined with resistance training, in older individuals with frailty...
2016: Journal of Frailty & Aging
P Hartley, J Adamson, C Cunningham, G Embleton, R Romero-Ortuno
Extra physiotherapy has been associated with better outcomes in hospitalized patients, but this remains an under-researched area in geriatric medicine wards. We retrospectively studied the association between average physiotherapy frequency and outcomes in hospitalized geriatric patients. High frequency physiotherapy (HFP) was defined as ≥0.5 contacts/day. Of 358 eligible patients, 131 (36.6%) received low, and 227 (63.4%) HFP. Functional improvement (discharge versus admission) in the modified Rankin scale was greater in the HFP group (1...
2016: Journal of Frailty & Aging
M Hawker, R Romero-Ortuno
The factors determining hospital discharge outcomes in older people are complex. This retrospective study was carried out in an in-patient geriatric ward over a month in 2015 and aimed to explore if self-reported feeling of loneliness and clinical frailty contribute to longer hospital stays or higher rates of readmission to hospital after discharge in the older population. Twenty-two men and twenty-five women (mean age 85.1 years) were assessed. There was a significant multivariate association between both self-reported loneliness (p=0...
2016: Journal of Frailty & Aging
C Siordia, Y D Covington-Ward
BACKGROUND: The field of aging studies continues to better understand between-racial-group health disparities. Previous work provides empirical evidence for a statistical relationship between perceived discrimination and adverse health across all age groups. SPECIFIC AIM: We contribute to the literature by investigating the quantitative relationship between Perceived Ethnic Discrimination (PED), Self-Rated Physical Health (SR-PH), Self-Rated Mental Health (SR-MH), and their combined score (SR-PH-MH)...
2016: Journal of Frailty & Aging
R O'Caoimh, N Cornally, A Svendrovski, E Weathers, C FitzGerald, E Healy, E O'Connell, G O'Keeffe, E O'Herlihy, Y Gao, R O'Donnell, R O'Sullivan, P Leahy-Warren, F Orfila, C Paúl, R Clarnette, D W Molloy
BACKGROUND: Although caregivers are important in the management of frail, community-dwelling older adults, the influence of different caregiver network types on the risk of adverse healthcare outcomes is unknown. OBJECTIVE: To examine the association between caregiver type and the caregiver network subtest of The Risk Instrument for Screening in the Community (RISC), a five point Likert scale scored from one ("can manage") to five ("absent/liability"). To measure the association between caregiver network scores and the one-year incidence of institutionalisation, hospitalisation and death...
2016: Journal of Frailty & Aging
K Palmer, A Marengoni, P Russo, F Mammarella, G Onder
No abstract text is available yet for this article.
2016: Journal of Frailty & Aging
T Woo, S Yu, R Visvanathan
Sarcopenia is a multi-faceted geriatric syndrome that is prevalent in the older population. It is an independent risk factor for a variety of devastating health outcomes that threaten the independence of older people. Quality of life is also very important to older people. The objective of this systematic review therefore was to determine the relationship between the biomarkers of sarcopenia (or sarcopenia) and health related quality of life in older people. Systematic searches were done using the electronic databases from MEDLINE and EMBASE...
2016: Journal of Frailty & Aging
J Laussen, C Kowaleski, K Martin, C Hickey, R A Fielding, K F Reid
BACKGROUND: As the population of older adults continues to increase, the dissemination of strategies to maintain independence of older persons is of critical public health importance. Recent large-scale clinical trial evidence has definitively shown intervention of moderate-intensity physical activity (PA) reduces major mobility disability in at-risk older adults. However, it remains unknown whether structured PA interventions, with demonstrated efficacy in controlled, clinical environments, can be successfully disseminated into community settings to benefit wider populations of older adults...
2016: Journal of Frailty & Aging
I S Widagdo, N Pratt, M Russell, E E Roughead
Individuals identified as frail have been shown to be at an increased risk of adverse health outcomes. However, there is no gold standard frailty measure and frailty status can vary depending on the measure used, suggesting the measures perform differently. Construct validity can be used to assess a measure's performance. This study aimed to examine the construct validity of four frailty measures in an Australian older population using Rasch analysis. Frailty status among the 2087 participants aged 65 years and above from the Australian Longitudinal Study of Ageing (ALSA) was assessed using: frailty phenotype--FP, simplified frailty phenotype--SFP, frailty index--FI, and prognostic frailty score--PFS...
2016: Journal of Frailty & Aging
S Goisser, S Guyonnet, D Volkert
Inadequate nutritional intake is an important modifiable risk factor for frailty. Existing evidence supports the importance of adequate dietary quantity and especially quality to ensure sufficient intakes of energy, protein and micronutrients. However, to date no nutritional intervention or supplementation concept has emerged as being effective for the prevention or treatment of frailty. Further research, including specifically the group of frail older persons and those at risk of frailty, and focussing on functional benefits as an outcome, is needed to allow definite recommendations for optimal diet, i...
2016: Journal of Frailty & Aging
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