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Journal of Frailty & Aging

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https://www.readbyqxmd.com/read/27883172/can-an-intervention-with-testosterone-and-nutritional-supplement-improve-the-frailty-level-of-under-nourished-older-people
#1
O Theou, I Chapman, L Wijeyaratne, C Piantadosi, K Lange, V Naganathan, P Hunter, I D Cameron, K Rockwood, R Visvanathan
OBJECTIVE: To examine whether a testosterone and a high calorie nutritional supplement intervention can reduce frailty scores in undernourished older people using multiple frailty tools. DESIGN: Randomized controlled trial. SETTING/PARTICIPANTS: 53 community-dwelling, undernourished men and women aged >65 years from South Australia, Victoria and New South Wales. INTERVENTION: Intervention group received oral testosterone undecanoate and a high calorie supplement (2108-2416 kJ/day) whereas the control group received placebo testosterone and low calorie supplement (142-191 kJ/day)...
2016: Journal of Frailty & Aging
https://www.readbyqxmd.com/read/27883171/frailty-in-postmenopausal-african-american-and-hispanic-hiv-infected-women
#2
P Young, J Shah, C Zhang, D C Ferris, I Colon, M Bucovsky, M Punyanitya, D J McMahon, E Shane, M T Yin
Studies suggest frailty occurs earlier in HIV-infected individuals, but data in postmenopausal HIV-infected women are lacking. We assessed the prevalence of frailty and association with anthropometric measures in HIV-infected and uninfected postmenopausal women. Fried's frailty phenotype was measured in HIV-infected and uninfected Hispanic and African American postmenopausal women participating in a study of bone metabolism; fat and lean mass were measured by whole body dual energy x-ray absorptiometry (DXA)...
2016: Journal of Frailty & Aging
https://www.readbyqxmd.com/read/27883170/macvia-lr-fighting-chronic-diseases-for-active-and-healthy-ageing-in-languedoc-roussillon-a-success-story-of-the-european-innovation-partnership-on-active-and-healthy-ageing
#3
J Bousquet, R Bourret, T Camuzat, P Augé, J Bringer, M Noguès, O Jonquet, J E de la Coussaye, J Ankri, M Cesari, O Guérin, B Vellas, H Blain, S Arnavielhe, A Avignon, B Combe, G Canovas, C Daien, G Dray, A Dupeyron, C Jeandel, I Laffont, D Laune, C Marion, E Pastor, J Y Pélissier, B Galan, J Reynes, J C Reuzeau, A Bedbrook, S Granier, P A Adnet, M Amouyal, B Alomène, P L Bernard, C Berr, D Caimmi, P G Claret, D J Costa, J P Cristol, P Fesler, D Hève, J Millot-Keurinck, D Morquin, G Ninot, M C Picot, N Raffort, F Roubille, A Sultan, J Touchon, V Attalin, C Azevedo, M Badin, K Bakhti, B Bardy, M P Battesti, X Bobia, C Boegner, S Boichot, H Y Bonnin, S Bouly, C Boubakri, J L Bourrain, G Bourrel, V Bouix, V Bruguière, S Cade, W Camu, V Carre, G Cavalli, G Cayla, R Chiron, P Coignard, F Coroian, P Costa, J Cottalorda, B Coulet, A L Coupet, M C Courrouy-Michel, P Courtet, V Cros, F Cuisinier, M Danko, P Dauenhauer, M Dauzat, M David, J M Davy, D Delignières, P Demoly, J Desplan, P Dujols, G Dupeyron, O Engberink, M Enjalbert, C Fattal, J Fernandes, M Fouletier, P Fraisse, P Gabrion, M Gellerat-Rogier, A Gelis, C Genis, N Giraudeau, A Y Goucham, F Gouzi, F Gressard, J C Gris, B Guillot, D Guiraud, V Handweiler, M Hayot, C Hérisson, C Heroum, D Hoa, S Jacquemin, S Jaber, D Jakovenko, C Jorgensen, P Kouyoudjian, R Lamoureux, L Landreau, M Lapierre, D Larrey, C Laurent, M S Léglise, J M Lemaitre, A Le Quellec, F Leclercq, S Lehmann, B Lognos, Cj M Lussert, A Makinson, K Mandrick, P Mares, P Martin-Gousset, A Matheron, G Mathieu, M Meissonnier, G Mercier, P Messner, C Meunier, M Mondain, R Morales, J Morel, D Mottet, P Nérin, P Nicolas, F Nouvel, D Paccard, G Pandraud, M P Pasdelou, J L Pasquié, K Patte, S Perrey, Y M Pers, F Portejoie, J L E Pujol, X Quantin, I Quéré, S Ramdani, J Ribstein, I Rédini-Martinez, S Richard, K Ritchie, J P Riso, F Rivier, J M Robine, C Rolland, E Royère, D Sablot, J L Savy, L Schifano, P Senesse, R Sicard, Y Stephan, D Strubel, G Tallon, M Tanfin, H Tassery, I Tavares, K Torre, V Tribout, A Uziel, P Van de Perre, F Venail, C Vergne-Richard, G Vergotte, L Vian, F Vialla, F Viart, M Villain, E Viollet, M Ychou, J Mercier
The Région Languedoc Roussillon is the umbrella organisation for an interconnected and integrated project on active and healthy ageing (AHA). It covers the 3 pillars of the European Innovation Partnership on Active and Healthy Ageing (EIP on AHA): (A) Prevention and health promotion, (B) Care and cure, (C) and (D) Active and independent living of elderly people. All sub-activities (poly-pharmacy, falls prevention initiative, prevention of frailty, chronic respiratory diseases, chronic diseases with multimorbidities, chronic infectious diseases, active and independent living and disability) have been included in MACVIA-LR which has a strong political commitment and involves all stakeholders (public, private, patients, policy makers) including CARSAT-LR and the Eurobiomed cluster...
2016: Journal of Frailty & Aging
https://www.readbyqxmd.com/read/27883169/association-between-continuous-wearable-activity-monitoring-and-self-reported-functioning-in-assisted-living-facility-and-nursing-home-residents
#4
J Merilahti, I Korhonen
BACKGROUND: Physical functioning is a key factor in independent living, and its preclinical state assessment and monitoring during the subject's normal life would be beneficial. OBJECTIVES: The aim of the study is to analyse associations between ambulatory measured physical activity behaviour and sleep patterns (wrist actigraphy) and self-reported difficulties in performing activities of daily living. Participants, setting and design: 36 residents in assisted living facilities and nursing homes (average age=80...
2016: Journal of Frailty & Aging
https://www.readbyqxmd.com/read/27883168/exercise-interventions-for-preserving-physical-function-among-cancer-survivors-in-middle-to-late-life
#5
C W Daum, S K Cochrane, J D Fitzgerald, L Johnson, T W Buford
The purpose of this review was to evaluate randomized controlled trials aiming to preserve the functional status, i.e. physical capabilities, of middle-aged and older cancer survivors through a structured, physical exercise intervention. The study team performed a thorough search of the literature using six online databases. This literature search limited included studies to randomized controlled trials which implemented a structured physical activity intervention for middle- and older-aged adults diagnosed with cancer...
2016: Journal of Frailty & Aging
https://www.readbyqxmd.com/read/27883167/frailty-is-a-geriatric-syndrome-characterized-by-multiple-impairments-a-comprehensive-approach-is-needed
#6
L-K Chen, A-C Hwang, L-K Liu, W-J Lee, L-N Peng
OBJECTIVE: To evaluate the prevalence of frailty and the associated multimorbidity and functional impairments among community-dwelling middle-aged and elderly people in Taiwan. DESIGN: a cross-sectional study. SETTING: communities in I-Lan County of Taiwan. PARTICIPANTS: 1839 community-dwelling people aged 50 years and older. INTERVENTION: None. MEASUREMENTS: Frailty defined by Fried's criteria, Charlson's comorbidity index (CCI), Functional Autonomy Measurement System (SMAF), Center for Epidemiologic Studies Depression Scale (CES-D), Mini-Nutrition Assessment (MNA), Mini-Mental State Examination (MMSE), and Short Form-12 quality of life questionnaire...
2016: Journal of Frailty & Aging
https://www.readbyqxmd.com/read/27883166/effect-of-low-dose-rapamycin-on-senescence-markers-and-physical-functioning-in-older-adults-with-coronary-artery-disease-results-of-a-pilot-study
#7
M Singh, M D Jensen, A Lerman, S Kushwaha, C S Rihal, B J Gersh, A Behfar, T Tchkonia, R J Thomas, R J Lennon, L R Keenan, A G Moore, J L Kirkland
Rapamycin, an mTOR inhibitor affects senescence through suppression of senescence-associated secretory phenotype (SASP). We studied the safety and feasibility of low-dose rapamycin and its effect on SASP and frailty in elderly undergoing cardiac rehabilitation (CR). 13 patients; 6 (0.5mg), 6 (1.0mg), and 1 patient received 2mg oral rapamycin (serum rapamycin <6ng/ml) daily for 12 weeks. Median age was 73.9±7.5 years and 12 were men. Serum interleukin-6 decreased (2.6 vs 4.4 pg/ml) and MMP-3 (26 vs 23.5 ng/ml) increased...
2016: Journal of Frailty & Aging
https://www.readbyqxmd.com/read/27883165/-move-on-against-frailty-time-to-raise-awareness-about-frailty-and-prevention-of-disability-in-the-community
#8
M Inzitari, D Ruiz, J Martos, S Santaeugenia
No abstract text is available yet for this article.
2016: Journal of Frailty & Aging
https://www.readbyqxmd.com/read/27883164/sarcopenia-trials-in-specific-diseases-report-by-the-international-conference-on-frailty-and-sarcopenia-research-task-force
#9
B Vellas, R Fielding, S Bhasin, F Cerreta, B Goodpaster, J M Guralnik, S Kritchevsky, V Legrand, C Forkin, J Magaziner, J E Morley, L Rodriguez-Manas, R Roubenoff, S Studenski, D T Villareal, M Cesari
Muscle atrophy occurs as a consequence of a number of conditions, including cancer, chronic obstructive pulmonary disease (COPD), diabetes mellitus, heart failure, and other chronic diseases, where it is generally a predictor of poor survival. It also occurs as a consequence of disuse and an age-related loss of muscle mass and strength (sarcopenia). The aims of the 2016, International Conference on Frailty and Sarcopenia Research (ICFSR) Task Force were to examine how these specific chronic conditions have been employed in treatment trials thus far and how future trials using these patient groups might be designed for efficient identification of effective sarcopenia interventions...
2016: Journal of Frailty & Aging
https://www.readbyqxmd.com/read/27554321/cocoa-theobroma-cacao-polyphenol-rich-extract-increases-the-chronological-lifespan-of-saccharomyces-cerevisiae
#10
I Baiges, L Arola
BACKGROUND: Saccharomyces cerevisiae is a model organism with conserved aging pathways. Yeast chronological lifespan experiments mimic the processes involved in human non-dividing tissues, such as the nervous system or skeletal muscle, and can speed up the search for biomolecules with potential anti-aging effects before proceeding to animal studies. OBJECTIVE: To test the effectiveness of a cocoa polyphenol-rich extract (CPE) in expanding the S. cerevisiae chronological lifespan in two conditions: in the stationary phase reached after glucose depletion and under severe caloric restriction...
2016: Journal of Frailty & Aging
https://www.readbyqxmd.com/read/27554320/frailty-in-general-practice
#11
L Letrilliart, S Oustric
No abstract text is available yet for this article.
2016: Journal of Frailty & Aging
https://www.readbyqxmd.com/read/27554319/baseline-vulnerability-and-inpatient-frailty-status-in-relation-to-adverse-outcomes-in-a-surgical-cohort
#12
H-S Lin, N M Peel, R E Hubbard
This study aimed to derive measures of baseline vulnerability and inpatient frailty in elderly surgical patients and to study their association with adverse post-operative outcomes. Data from comprehensive geriatric assessment of 208 general surgical and orthopaedic patients aged 70 and over admitted to four acute hospitals in Queensland, Australia, were analysed to derive a baseline and inpatient Frailty Index (FI). The association of these indices with adverse outcomes was examined in logistic regression...
2016: Journal of Frailty & Aging
https://www.readbyqxmd.com/read/27554318/frailty-and-health-related-quality-of-life-in-end-stage-renal-disease-patients-of-all-ages
#13
M A McAdams-DeMarco, H Ying, I Olorundare, E A King, N Desai, N Dagher, B Lonze, R Montgomery, J Walston, D L Segev
BACKGROUND: Frailty is associated with worse health-related quality of life (HRQOL) in older adults and worse clinical outcomes in adults of all ages with end stage renal disease (ESRD). It is unclear whether frail adults of all ages with ESRD are more likely to experience worse HRQOL. OBJECTIVE: The goal of this study was to identify factors associated with worsening HRQOL in this population. Design, setting and measurements: We studied 233 adults of all ages with ESRD enrolled (11/2009-11/2013) in a longitudinal cohort study...
2016: Journal of Frailty & Aging
https://www.readbyqxmd.com/read/27554317/assessment-of-health-inequalities-among-older-people-using-the-epices-score-a-composite-index-of-social-deprivation
#14
B Bongue, A Colvez, E Amsallem, L Gerbaud, C Sass
BACKGROUND: Most of the indicators commonly used to assess social deprivation are poorly suited to study health inequalities in older people. The EPICES (Evaluation of Deprivation and Inequalities in Health Examination Centres) score is a new composite index commonly used to measure individual deprivation. OBJECTIVE: To assess the relationships between health indicators and the EPICES score in older people. DESIGN, SETTING, AND PARTICIPANTS: We performed a cross-sectional study using the data from the 2008 ESPS Survey (Health, HealthCare and Insurance Survey)...
2016: Journal of Frailty & Aging
https://www.readbyqxmd.com/read/27554316/the-emergence-of-frailty-may-lead-to-a-state-of-burnt-out-type-2-diabetes
#15
A H Abdelhafiz, L Koay, A J Sinclair
Ageing is associated with hyperglycaemic tendency due to the change in body composition leading to accumulation of visceral fat and increased insulin resistance on the one hand and reduced insulin secretion due to decreased number and function of the β-cells of the pancreas on the other. However, with the emergence of frailty there may be a tendency towards normoglycaemia or even hypoglycaemia due to malnutrition, weight loss and reduced physiologic reserve. This shift in glucose metabolism induced by frailty may change the natural history of type 2 diabetes from a progressive to a regressive course...
2016: Journal of Frailty & Aging
https://www.readbyqxmd.com/read/27554315/measuring-activity-performance-of-continuing-care-residents-using-the-activpal-an-exploratory-study
#16
C S Chan, S E Slaughter, C A Jones, A S Wagg
Few studies have measured the activity patterns of continuing care residents using objective, uniaxial, accelerometers such as the activPAL. This exploratory study described the activity performance of continuing care residents and explored the correlation of activity performance with grip strength, falls and mobility. Data were gathered from 24 continuing care residents. Participants (82.3 ± 5.8 years of age), wore the activPAL an average of 12.60 hours per day (SD = 0.96) and were stepping for a median of 0...
2016: Journal of Frailty & Aging
https://www.readbyqxmd.com/read/27554314/factors-associated-with-nutritional-risk-among-homebound-older-adults-with-depressive-symptoms
#17
A P Greenfield, S Banerjee, A DePasquale, N Weiss, J Sirey
OBJECTIVES: This study used the Evans model of public health determinants to identify factors associated with nutritional risk in older adults. DESIGN: The Evans model domains (physical and mental well-being, social/environmental statuses, individual choice, and economic security) were measured in a sample of homebound older adults. Regularized logistic regression analysis with LASSO penalty function was used to determine the strongest domain of the Evans model...
2016: Journal of Frailty & Aging
https://www.readbyqxmd.com/read/27554313/association-between-nutritional-status-and-quality-of-life-in-pre-frail-community-dwelling-older-persons
#18
E Luger, S Haider, A Kapan, K Schindler, C Lackinger, T E Dorner
BACKGROUND: For developed countries, healthy aging is one of the challenges and the number of healthy life years and especially the quality of life (QoL) are important. OBJECTIVE: This study aimed to assess the association between nutritional status and different domains of QoL in (pre)frail community-dwelling elders. DESIGN: Baseline data from persons, who participated in a 12-week nutritional and physical training intervention program, conducted from September 2013 - July 2015...
2016: Journal of Frailty & Aging
https://www.readbyqxmd.com/read/27554312/baseline-frailty-evaluation-in-drug-development
#19
F Cerreta, J Ankri, D Bowen, A Cherubini, A J Cruz Jentoft, A Guðmundsson, M Haberkamp, P Jansen, N Marchionni, S Morgan, E Rönnemaa, M Petrovic, A Pilotto, M Rosa, H Wildiers
No abstract text is available yet for this article.
2016: Journal of Frailty & Aging
https://www.readbyqxmd.com/read/27224505/resistance-training-and-co-supplementation-with-creatine-and-protein-in-older-subjects-with-frailty
#20
RANDOMIZED CONTROLLED TRIAL
J Collins, G Longhurst, H Roschel, B Gualano
BACKGROUND: Studies assessing the effects co-supplementation with creatine and protein, along with resistance training, in older individuals with frailty are lacking. OBJECTIVES: This is an exploratory trial from the Pro-Elderly study ("Protein Intake and Resistance Training in Aging") aimed at gathering knowledge on the feasibility, safety, and efficacy of co-supplementation with creatine and protein supplementation, combined with resistance training, in older individuals with frailty...
2016: Journal of Frailty & Aging
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