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Journal of Frailty & Aging

E Normandin, D Yow, C Crotts, J Kiel, K M Beavers, B J Nicklas
BACKGROUND: While intentional weight loss in older adults with obesity yields clinically important health benefits there is a need to minimize the negative effects of weight loss on concomitant loss of muscle mass and strength. Data show wearing weighted vests during exercise improves lean mass and lower extremity strength, however the efficacy of wearing a weighted vest during a period of weight loss to mitigate muscle and strength loss is not known. OBJECTIVES: This study examined the feasibility of daily weighted vest use during a dietary weight loss intervention, and examined effects of vest use on body composition and physical function in well-functioning older adults with obesity...
2018: Journal of Frailty & Aging
D Azzolino, S Damanti, M Cesari
No abstract text is available yet for this article.
2018: Journal of Frailty & Aging
J Dollard, G Harvey, E Dent, L Trotta, N Williams, J Beilby, E Hoon, A Kitson, C Seiboth, J Karnon
Older frequent users of acute care can experience fragmented care. There is a need to understand the issues in a local context before attempting to address fragmented care. 0.5% (n=61) of the population in a defined local government area were identified as having ≥4 unplanned emergency department (ED) presentations/ admissions to an acute-care hospital over 13 months. A retrospective case-series study was conducted to examine detailed pathways of care for 17 patients within the identified population. The two dominant presentation reasons were clinical symptoms associated with a declining/significant loss of capacity in fundamental self-care activities and chronic cardiac/respiratory conditions...
2018: Journal of Frailty & Aging
Y Okubo, M Nemoto, Y Osuka, S Jung, S Seino, R Figueroa, G Vinyes-Pares, E A Offord, M Shevlyakova, D Breuille, K Tanaka
OBJECTIVE: Develop and evaluate the feasibility and validity of the Nutrition and Functionality Assessment (NFA) which identifies "target" older adults who could benefit from a personalized program following evaluation of their nutrition status and physical functionality. DESIGN: Cross-sectional study. SETTING: Community and geriatric day-care centers and university in Japan. PARTICIPANTS: 267 older adults aged 65-90...
2018: Journal of Frailty & Aging
J M Beasley, M A Sevick, L Kirshner, M Mangold, J Chodosh
BACKGROUND: Through diet and exercise interventions, community centers offer an opportunity to address health-related issues for some of the oldest, most vulnerable members of our society. OBJECTIVES: The purpose of this investigation is to draw upon nationwide data to better characterize the population served by the congregate meals program and to gather more detailed information on a local level to identify opportunities for service enhancement to improve the health and well-being of older adults...
2018: Journal of Frailty & Aging
M Locquet, C Beaudart, L Delandsheere, J-Y Reginster, O Bruyère
BACKGROUND: It seems that sleep quality could impact the physiological process related to loss of muscle mass. OBJECTIVES: We seek to compare subjective sleep quality of sarcopenic and non-sarcopenic subjects diagnosed according to 6 definitions. DESIGN: Cross-sectional data used in this analysis were collected from the SarcoPhAge (Sarcopenia and Physical Impairment with Advancing Age) cohort, a prospective study aiming to assess clinical parameters linked to sarcopenia...
2018: Journal of Frailty & Aging
F Potier, J-M Degryse, G Aubouy, S Henrard, B Bihin, F Debacq-Chainiaux, H Martens, M de Saint-Hubert
BACKGROUND: Evidence suggests that providing care for a disabled elderly person may have implications for the caregiver's own health (decreased immunity, hypertension, and depression). OBJECTIVE: Explore if older spousal caregivers are at greater risks of frailty compared to older people without a load of care. DESIGN: Case-control study. SETTING: Participants were assessed at home in Wallonia, Belgium. PARTICIPANTS: Cases: community-dwelling spousal caregivers of older patients, recruited mainly by the geriatric outpatient clinic...
2018: Journal of Frailty & Aging
D Orwig, M C Hochberg, A L Gruber-Baldini, B Resnick, R R Miller, G E Hicks, A R Cappola, M Shardell, R Sterling, J R Hebel, R Johnson, J Magaziner
BACKGROUND: Incidence of hip fractures in men is expected to increase, yet little is known about consequences of hip fracture in men compared to women. It is important to investigate differences at time of fracture using the newest technologies and methodology regarding metabolic, physiologic, neuromuscular, functional, and clinical outcomes, with attention to design issues for recruiting frail older adults across numerous settings. OBJECTIVES: To determine whether at least moderately-sized sex differences exist across several key outcomes after a hip fracture...
2018: Journal of Frailty & Aging
N W Bray, T J Doherty, M Montero-Odasso
BACKGROUND: Vitamin D deficiency is ubiquitous in frailty but the effectiveness of vitamin D supplementation to improve outcomes in frail individuals is unclear. It has been postulated that higher than the current recommended doses (800 IU/day) may be needed to achieve a neuromuscular effect in frail individuals. OBJECTIVES: 1) determine if 4000 IU per day of vitamin D3 is safe for frail older adults; and 2) establish the efficacy of this dose to improve physical performance outcomes in this population...
2018: Journal of Frailty & Aging
M Pahor, S B Kritchevsky, D L Waters, D T Villareal, J Morley, J M Hare, B Vellas
To reduce disability and dependence in older adults, frailty may represent an appropriate target for intervention. While preventing frailty through lifestyle interventions may be the optimal public health approach for many population groups, pharmacological approaches will likely be needed for individuals who meet frailty criteria or who have comorbid conditions that contribute to and complicate the frailty syndrome, and for those who are not compliant with lifestyle interventions. Barriers to successful development of drug treatments for frailty include variability in how the frailty syndrome is defined, lack of agreement on the best diagnostic tools and outcome measures, and the paucity of sensitive, reliable, and validated biomarkers...
2018: Journal of Frailty & Aging
R T Mankowski, C Leeuwenburgh, T M Manini, A J Woods, S D Anton
Fermented Papaya Preparation (FPP®) has shown antioxidative and anti-inflammatory effects in preclinical and clinical aging studies. However, clinical trials are needed to fully evaluate the safety of FPP® in moderate-functioning, generally healthy older adults. In this randomized (9g/day of FPP® or placebo), crossover design study, we enrolled 30 older moderate-functioning older adults (70-100 years old). The participants completed both a treatment and a placebo condition. After eight (8) weeks on each of these regimens (with a 4-week wash-out period in between), participants had their venous blood drawn for assessment of blood chemistries, metabolic outcomes and inflammatory biomarkers...
2018: Journal of Frailty & Aging
K Khatry, N M Peel, L C Gray, R E Hubbard
Using clinical vignettes, this study aimed to determine if a measure of patient frailty would impact management decisions made by geriatricians regarding commonly encountered clinical situations. Electronic surveys consisting of three vignettes derived from cases commonly seen in an acute inpatient ward were distributed to geriatricians. Vignettes included patients being considered for intensive care treatment, rehabilitation, or coronary artery bypass surgery. A frailty index was generated through Comprehensive electronic Geriatric Assessment...
2018: Journal of Frailty & Aging
R E Ediriweera de Silva, M S A Perera
BACKGROUND: This study aimed to assess the quality of life (QoL) and identify factors influencing it in older adults attending a University Family Practice situated in a semi-urban area in Sri Lanka, a lower middle income country. OBJECTIVES: To describe the QoL among older adults attending the Family Practice Centre, University of Sri Jayewardenepura. DESIGN: A descriptive cross sectional study. SETTING: Family Practice Centre, University of Sri Jayewardenepura, Sri Lanka...
2018: Journal of Frailty & Aging
B Buta, D Leder, R Miller, N L Schoenborn, A R Green, R Varadhan
INTRODUCTION: Frailty affects 15% of non-institutionalized older adults in the United States, yet confusion remains in defining and, in turn, assessing frailty. Figurative language, such as metaphor, can help to explain difficult scientific concepts and to form new theories. We aimed to examine the use of figurative language to describe frailty and to identify themes in the way figurative expressions are used. Understanding how frailty is described figuratively may offer insights for developing useful communication approaches in research settings...
2018: Journal of Frailty & Aging
J de Kerimel, N Tavassoli, C Lafont, M Soto, M Pedra, F Nourhashemi, C Lagourdette, L Bouchon, A Chaléon, S Sourdet, Y Rolland, M Cesari, B Vellas
BACKGROUND: Health promotion programs could prevent and delay frailty and functional decline. However, in practice, the planning and establishment of such a program is a challenge for health care providers. We report an experimental model of screening and management for frail elderly conducted in Cugnaux, city of 16,638 inhabitants in France, by the Toulouse Gerontopole and the social care service of the Cugnaux City Hall. METHODS: A frailty screening self-administered questionnaire (FiND questionnaire) was sent to community-dwelling residents of 70 years old and over of Cugnaux...
2018: Journal of Frailty & Aging
A D Jadczak, K L Tam, R Visvanathan
BACKGROUND: Exercise courses during medical school contribute to medical students' confidence in promoting physical activity to their patients. However, there is still a lack of uniform physical activity education across medical school curricula to equip medical students with the necessary skills and knowledge to counsel their patients about exercise. OBJECTIVE: To determine the effects of a 1.5-hour physical activity module including a one-hour exercise tutorial combined with a 30-minute practical counselling session on senior medical students' perceptions of the importance of exercise and their perceived competence in advising older people about exercise...
2018: Journal of Frailty & Aging
I Aprahamian, M M Biella, G Vano Aricó de Almeida, F Pegoraro, A V Alves Pedrini, B Cestari, L H Bignotto, B Alvarez Ribeiro de Melo, J E Martinelli
OBJECTIVES: the aims of the present study were: (1) investigate the prevalence and association of polypharmacy and pre-frailty or frailty in a middle-income country sample of older adults; and (2) evaluate the prevalence of potential inappropriate prescription (PIP) and its association with pre-frailty or frailty. DESIGN: Cross-sectional observational study. SETTING: Outpatient center at a university-based hospital in the state of São Paulo, Brazil...
2018: Journal of Frailty & Aging
M J Benton, A L Silva-Smith
We compared accuracy of body mass index (BMI) versus lean mass index (LMI) to predict sarcopenia in 58 community-dwelling women (74.1±0.9 years). Lean mass was measured with multi-frequency bioelectrical impedance analysis, and strength was measured with Arm Curl test, Chair Stand test, and handgrip dynamometry. Sarcopenia was defined as low LMI. When categorized by BMI, normal women had less absolute lean mass (37.6±1.0 vs. 42.6±0.9 kg; P<0.001) and less relative lean mass (14.1±0.2 vs. 16.1±0.2 kg/m2; P<0...
2018: Journal of Frailty & Aging
B R Ipson, M B Fletcher, S E Espinoza, A L Fisher
Frailty is a geriatric syndrome associated with progressive physical decline and significantly increases risk for falls, disability, hospitalizations, and death. However, much remains unknown regarding the biological mechanisms that contribute to aging and frailty, and to date, there are no clinically used prognostic or diagnostic molecular biomarkers. The present study profiled exosome-derived microRNAs isolated from the plasma of young, robust older, and frail older individuals and identified eight miRNAs that are uniquely enriched in frailty: miR-10a-3p, miR-92a-3p, miR-185-3p, miR-194-5p, miR-326, miR-532-5p, miR-576-5p, and miR-760...
2018: Journal of Frailty & Aging
M Pourhassan, R Wirth
BACKGROUND AND OBJECTIVES: Seasonal variation in 25-hydroxyvitamin D [25(OH)D] levels is the result of sunlight dependent skin synthesis of vitamin D. However, its presence is not studied in frail older hospitalized patients. We sought to investigate whether seasonal variation in 25(OH)D levels is evident among these patients. DESIGN AND SETTING: This study investigated older participants who were consecutively admitted between February 2015 and December 2016 to the geriatric acute care ward...
2018: Journal of Frailty & Aging
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