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Journal of Frailty & Aging

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https://www.readbyqxmd.com/read/29741201/effects-of-fermented-papaya-preparation-fpp-on-safety-outcomes-in-older-adults-a-short-report-of-a-placebo-controlled-clinical-trial
#1
R T Mankowski, C Leeuwenburgh, T M Manini, A J Woods, S D Anton
Fermented Papaya Preparation (FPP®) has shown antioxidative and anti-inflammatory effects in preclinical and clinical aging studies. However, clinical trials are needed to fully evaluate the safety of FPP® in moderate-functioning, generally healthy older adults. In this randomized (9g/day of FPP® or placebo), crossover design study, we enrolled 30 older moderate-functioning older adults (70-100 years old). The participants completed both a treatment and a placebo condition. After eight (8) weeks on each of these regimens (with a 4-week wash-out period in between), participants had their venous blood drawn for assessment of blood chemistries, metabolic outcomes and inflammatory biomarkers...
2018: Journal of Frailty & Aging
https://www.readbyqxmd.com/read/29741200/the-utility-of-the-frailty-index-in-clinical-decision-making
#2
K Khatry, N M Peel, L C Gray, R E Hubbard
Using clinical vignettes, this study aimed to determine if a measure of patient frailty would impact management decisions made by geriatricians regarding commonly encountered clinical situations. Electronic surveys consisting of three vignettes derived from cases commonly seen in an acute inpatient ward were distributed to geriatricians. Vignettes included patients being considered for intensive care treatment, rehabilitation, or coronary artery bypass surgery. A frailty index was generated through Comprehensive electronic Geriatric Assessment...
2018: Journal of Frailty & Aging
https://www.readbyqxmd.com/read/29741199/quality-of-life-in-older-adults-attending-a-university-family-practice-centre-in-sri-lanka
#3
R E Ediriweera de Silva, M S A Perera
BACKGROUND: This study aimed to assess the quality of life (QoL) and identify factors influencing it in older adults attending a University Family Practice situated in a semi-urban area in Sri Lanka, a lower middle income country. OBJECTIVES: To describe the QoL among older adults attending the Family Practice Centre, University of Sri Jayewardenepura. DESIGN: A descriptive cross sectional study. SETTING: Family Practice Centre, University of Sri Jayewardenepura, Sri Lanka...
2018: Journal of Frailty & Aging
https://www.readbyqxmd.com/read/29741198/the-use-of-figurative-language-to-describe-frailty-in-older-adults
#4
B Buta, D Leder, R Miller, N L Schoenborn, A R Green, R Varadhan
INTRODUCTION: Frailty affects 15% of non-institutionalized older adults in the United States, yet confusion remains in defining and, in turn, assessing frailty. Figurative language, such as metaphor, can help to explain difficult scientific concepts and to form new theories. We aimed to examine the use of figurative language to describe frailty and to identify themes in the way figurative expressions are used. Understanding how frailty is described figuratively may offer insights for developing useful communication approaches in research settings...
2018: Journal of Frailty & Aging
https://www.readbyqxmd.com/read/29741197/how-to-manage-frail-older-adults-in-the-community-proposal-of-a-health-promotion-program-experienced-in-a-city-of-16-638-inhabitants-in-france
#5
J de Kerimel, N Tavassoli, C Lafont, M Soto, M Pedra, F Nourhashemi, C Lagourdette, L Bouchon, A Chaléon, S Sourdet, Y Rolland, M Cesari, B Vellas
BACKGROUND: Health promotion programs could prevent and delay frailty and functional decline. However, in practice, the planning and establishment of such a program is a challenge for health care providers. We report an experimental model of screening and management for frail elderly conducted in Cugnaux, city of 16,638 inhabitants in France, by the Toulouse Gerontopole and the social care service of the Cugnaux City Hall. METHODS: A frailty screening self-administered questionnaire (FiND questionnaire) was sent to community-dwelling residents of 70 years old and over of Cugnaux...
2018: Journal of Frailty & Aging
https://www.readbyqxmd.com/read/29741196/educating-medical-students-in-counselling-older-adults-about-exercise-the-impact-of-a-physical-activity-module
#6
A D Jadczak, K L Tam, R Visvanathan
BACKGROUND: Exercise courses during medical school contribute to medical students' confidence in promoting physical activity to their patients. However, there is still a lack of uniform physical activity education across medical school curricula to equip medical students with the necessary skills and knowledge to counsel their patients about exercise. OBJECTIVE: To determine the effects of a 1.5-hour physical activity module including a one-hour exercise tutorial combined with a 30-minute practical counselling session on senior medical students' perceptions of the importance of exercise and their perceived competence in advising older people about exercise...
2018: Journal of Frailty & Aging
https://www.readbyqxmd.com/read/29741195/polypharmacy-but-not-potential-inappropriate-prescription-was-associated-with-frailty-in-older-adults-from-a-middle-income-country-outpatient-clinic
#7
I Aprahamian, M M Biella, G Vano Aricó de Almeida, F Pegoraro, A V Alves Pedrini, B Cestari, L H Bignotto, B Alvarez Ribeiro de Melo, J E Martinelli
OBJECTIVES: the aims of the present study were: (1) investigate the prevalence and association of polypharmacy and pre-frailty or frailty in a middle-income country sample of older adults; and (2) evaluate the prevalence of potential inappropriate prescription (PIP) and its association with pre-frailty or frailty. DESIGN: Cross-sectional observational study. SETTING: Outpatient center at a university-based hospital in the state of São Paulo, Brazil...
2018: Journal of Frailty & Aging
https://www.readbyqxmd.com/read/29741194/accuracy-of-body-mass-index-versus-lean-mass-index-for-prediction-of-sarcopenia-in-older-women
#8
M J Benton, A L Silva-Smith
We compared accuracy of body mass index (BMI) versus lean mass index (LMI) to predict sarcopenia in 58 community-dwelling women (74.1±0.9 years). Lean mass was measured with multi-frequency bioelectrical impedance analysis, and strength was measured with Arm Curl test, Chair Stand test, and handgrip dynamometry. Sarcopenia was defined as low LMI. When categorized by BMI, normal women had less absolute lean mass (37.6±1.0 vs. 42.6±0.9 kg; P<0.001) and less relative lean mass (14.1±0.2 vs. 16.1±0.2 kg/m2; P<0...
2018: Journal of Frailty & Aging
https://www.readbyqxmd.com/read/29741193/identifying-exosome-derived-micrornas-as-candidate-biomarkers-of-frailty
#9
B R Ipson, M B Fletcher, S E Espinoza, A L Fisher
Frailty is a geriatric syndrome associated with progressive physical decline and significantly increases risk for falls, disability, hospitalizations, and death. However, much remains unknown regarding the biological mechanisms that contribute to aging and frailty, and to date, there are no clinically used prognostic or diagnostic molecular biomarkers. The present study profiled exosome-derived microRNAs isolated from the plasma of young, robust older, and frail older individuals and identified eight miRNAs that are uniquely enriched in frailty: miR-10a-3p, miR-92a-3p, miR-185-3p, miR-194-5p, miR-326, miR-532-5p, miR-576-5p, and miR-760...
2018: Journal of Frailty & Aging
https://www.readbyqxmd.com/read/29741192/seasonal-variation-in-vitamin-d-status-among-frail-older-hospitalized-patients
#10
M Pourhassan, R Wirth
BACKGROUND AND OBJECTIVES: Seasonal variation in 25-hydroxyvitamin D [25(OH)D] levels is the result of sunlight dependent skin synthesis of vitamin D. However, its presence is not studied in frail older hospitalized patients. We sought to investigate whether seasonal variation in 25(OH)D levels is evident among these patients. DESIGN AND SETTING: This study investigated older participants who were consecutively admitted between February 2015 and December 2016 to the geriatric acute care ward...
2018: Journal of Frailty & Aging
https://www.readbyqxmd.com/read/29412445/8th-international-conference-on-frailty-and-sarcopenia-research-icfsr-march-1-3-2018-miami-usa-symposia-conference-oral-communications
#11
(no author information available yet)
No abstract text is available yet for this article.
2018: Journal of Frailty & Aging
https://www.readbyqxmd.com/read/29412444/frailty-and-neurodegenerative-disease-anticipating-the-future-expanding-the-framework
#12
D M Lyreskog
An array of technologies for preventing and treating age-related neural decline and disease are currently under development. A clear framework for how to identify groups in need of such inventions is needed. An encompassing concept of frailty could provide a solid basis for such purposes. Concepts of frailty, including physical and cognitive frailty, are currently applied in clinical settings, and in research and development. The terminology facilitates identifying processes of age-related physical and cognitive decline...
2018: Journal of Frailty & Aging
https://www.readbyqxmd.com/read/29412443/muscle-quality-improves-with-extended-high-intensity-resistance-training-after-hip-fracture
#13
R A Briggs, J R Houck, M J Drummond, J M Fritz, P C LaStayo, R L Marcus
BACKGROUND: Muscle mass deficits endure after hip fracture. Strategies to improve muscle quality may improve mobility and physical function. It is unknown whether training after usual care yields muscle quality gains after hip fracture. OBJECTIVES: To determine whether muscle quality improves after hip fracture with high-intensity resistance training and protein supplementation. DESIGN: Case series. SETTING: University of Utah Skeletal Muscle Exercise Research Facility...
2018: Journal of Frailty & Aging
https://www.readbyqxmd.com/read/29412442/preliminary-study-on-prevalence-and-associated-factors-with-sarcopenia-in-a-geriatric-hospitalized-rehabilitation-setting
#14
K Pongpipatpaiboon, I Kondo, K Onogi, S Mori, K Ozaki, A Osawa, H Matsuo, N Itoh, M Tanimoto
The reported prevalence of sarcopenia has shown a wide range, crucially based on the diagnostic criteria and setting. This cross-sectional study evaluated the prevalence of sarcopenia and sought to identify factors associated with sarcopenia on admission in a specialized geriatric rehabilitation setting based on the newly developed the Asian Working Group for Sarcopenia algorithm. Among 87 participants (mean age, 76.05 ± 7.57 years), 35 (40.2%) were classified as showing sarcopenia on admission. Prevalence was high, particularly among participants ≥80 years old, with tendencies toward lower body mass index, smoking habit, lower cognitive function, and greater functional impairment compared with the non-sarcopenic group...
2018: Journal of Frailty & Aging
https://www.readbyqxmd.com/read/29412441/impact-of-sarcopenia-on-one-year-mortality-among-older-hospitalized-patients-with-impaired-mobility
#15
M Pourhassan, K Norman, M J Müller, R Dziewas, R Wirth
OBJECTIVES: However, the information regarding the impact of sarcopenia on mortality in older individuals is rising, there is a lack of knowledge concerning this issue among geriatric hospitalized patients. Therefore, aim of the present study was to investigate the associations between sarcopenia and 1-year mortality in a prospectively recruited sample of geriatric inpatients with different mobility and dependency status. DESIGN AND SETTING: Sarcopenia was diagnosed using the criteria of the European Working Group on Sarcopenia in Older People (EWGSOP)...
2018: Journal of Frailty & Aging
https://www.readbyqxmd.com/read/29412440/precipitants-of-delirium-in-older-inpatients-admitted-in-surgery-for-post-fall-hip-fracture-an-observational-study
#16
E Levinoff, A Try, J Chabot, L Lee, D Zukor, O Beauchet
BACKGROUND: Hip fractures precipitate several acute adverse outcomes in elderly people, thus leading to chronic adverse outcomes. OBJECTIVES: The objective of our study was to examine the clinical characteristics associated with incident delirium in community dwelling elderly individuals who have a hip fracture. DESIGN: Retrospective observational cohort study. SETTING: Data was collected from an academic tertiary hospital affiliated with McGill University...
2018: Journal of Frailty & Aging
https://www.readbyqxmd.com/read/29412439/new-simplified-screening-method-for-postprandial-hypotension-in-older-people
#17
MULTICENTER STUDY
R Abbas, A Tanguy, D Bonnet-Zamponi, R Djedid, A Lounis, M-L Gaubert-Dahan
BACKGROUND: Postprandial hypotension (PPH) is an important disorder in the older people that remain underdiagnosed. The reference PPH diagnostic method is too demanding, because blood pressure (BP) needs to be measured 8 times in 2 hours. OBJECTIVES: Our primary objective was to define a new simplified PPH diagnostic method and to evaluate its performances. DESIGN: We conducted a cross-sectional study. SETTING: Two geriatric rehabilitation units in France...
2018: Journal of Frailty & Aging
https://www.readbyqxmd.com/read/29412438/the-vicious-cycle-of-myostatin-signaling-in-sarcopenic-obesity-myostatin-role-in-skeletal-muscle-growth-insulin-signaling-and-implications-for-clinical-trials
#18
REVIEW
L A Consitt, B C Clark
The age-related loss of skeletal muscle (sarcopenia) is a major health concern as it is associated with physical disability, metabolic impairments, and increased mortality. The coexistence of sarcopenia with obesity, termed 'sarcopenic obesity', contributes to skeletal muscle insulin resistance and the development of type 2 diabetes, a disease prevalent with advancing age. Despite this knowledge, the mechanisms contributing to sarcopenic obesity remain poorly understood, preventing the development of targeted therapeutics...
2018: Journal of Frailty & Aging
https://www.readbyqxmd.com/read/29412437/an-international-position-statement-on-the-management-of-frailty-in-diabetes-mellitus-summary-of-recommendations-2017
#19
REVIEW
A J Sinclair, A Abdelhafiz, T Dunning, M Izquierdo, L Rodriguez Manas, I Bourdel-Marchasson, J E Morley, M Munshi, J Woo, B Vellas
AIM: The International Position Statement provides the opportunity to summarise all existing clinical trial and best practice evidence for older people with frailty and diabetes. It is the first document of its kind and is intended to support clinical decisions that will enhance safety in management and promote high quality care. METHODS: The Review Group sought evidence from a wide range of studies that provide sufficient confidence (in the absence of grading) for the basis of each recommendation...
2018: Journal of Frailty & Aging
https://www.readbyqxmd.com/read/29412436/implications-of-icd-10-for-sarcopenia-clinical-practice-and-clinical-trials-report-by-the-international-conference-on-frailty-and-sarcopenia-research-task-force
#20
B Vellas, R A Fielding, C Bens, R Bernabei, P M Cawthon, T Cederholm, A J Cruz-Jentoft, S Del Signore, S Donahue, J Morley, M Pahor, J-Y Reginster, L Rodriguez Mañas, Y Rolland, R Roubenoff, A Sinclair, M Cesari
Establishment of an ICD-10-CM code for sarcopenia in 2016 was an important step towards reaching international consensus on the need for a nosological framework of age-related skeletal muscle decline. The International Conference on Frailty and Sarcopenia Research Task Force met in April 2017 to discuss the meaning, significance, and barriers to the implementation of the new code as well as strategies to accelerate development of new therapies. Analyses by the Sarcopenia Definitions and Outcomes Consortium are underway to develop quantitative definitions of sarcopenia...
2018: Journal of Frailty & Aging
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