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Intestinal Research

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https://www.readbyqxmd.com/read/29743850/a-huge-mass-causing-colonic-obstruction-at-the-hepatic-flexure
#1
Chang Hwi Yoon, Byoung Wook Bang, Kye Sook Kwon, Hyung Kil Kim, Yong Woon Shin
No abstract text is available yet for this article.
April 2018: Intestinal Research
https://www.readbyqxmd.com/read/29743849/author-s-reply
#2
Sakiko Hiraoka, Jun Kato, Hiroyuki Okada
No abstract text is available yet for this article.
April 2018: Intestinal Research
https://www.readbyqxmd.com/read/29743848/the-old-versus-the-new-which-do-you-keep-in-postoperative-crohn-s-disease
#3
Paulo Gustavo Kotze, Christopher Ma, Miguel Regueiro, Remo Panaccione
No abstract text is available yet for this article.
April 2018: Intestinal Research
https://www.readbyqxmd.com/read/29743847/efficacy-and-tolerability-of-methotrexate-therapy-for-refractory-intestinal-beh%C3%A3-et-s-disease-a-single-center-experience
#4
Jihye Park, Jae Hee Cheon, Yehyun Park, Soo Jung Park, Tae Il Kim, Won Ho Kim
No abstract text is available yet for this article.
April 2018: Intestinal Research
https://www.readbyqxmd.com/read/29743846/should-asian-inflammatory-bowel-disease-patients-need-routine-thromboprophylaxis
#5
Meng-Tzu Weng, Chien-Chih Tung, Jau-Min Wong, Shu-Chen Wei
No abstract text is available yet for this article.
April 2018: Intestinal Research
https://www.readbyqxmd.com/read/29743845/a-case-of-ulcerative-colitis-presenting-with-cerebral-venous-thrombosis
#6
Junghwan Lee, Sung Wook Hwang, Jinhee Lee, Kyung Hwa Jung, Ha Il Kim, Sang Hyoung Park, Dong-Hoon Yang, Byong Duk Ye, Jeong-Sik Byeon, Seung-Jae Myung, Suk-Kyun Yang
Patients with inflammatory bowel disease (IBD) have been reported to have an increased risk of thromboembolism. Cerebral venous thrombosis (CVT) is a rare but serious extraintestinal manifestation of IBD. Due to its highly variable manifestation and low incidence, CVT is not usually readily recognized by physicians. Herein, we report a case of a 35-year-old male presenting with CVT associated with ulcerative colitis (UC). The patient was admitted with chief complaints of bloody diarrhea that had started 3 days prior...
April 2018: Intestinal Research
https://www.readbyqxmd.com/read/29743844/difficult-colonoscopy-air-carbon-dioxide-or-water-insufflation
#7
Alisha Chaubal, Vikas Pandey, Ruchir Patel, Prateik Poddar, Aniruddha Phadke, Meghraj Ingle, Prabha Sawant
Background/Aims: This study aimed to compare tolerance to air, carbon dioxide, or water insufflation in patients with anticipated difficult colonoscopy (young, thin, obese individuals, and patients with prior abdominal surgery or irradiation). Methods: Patients with body mass index (BMI) less than 18 kg/m2 or more than 30 kg/m2 , or who had undergone previous abdominal or pelvic surgeries were randomized to air, carbon dioxide, or water insufflation during colonoscopy...
April 2018: Intestinal Research
https://www.readbyqxmd.com/read/29743843/prospective-analysis-of-factors-associated-with-inadequate-bowel-preparation-for-colonoscopy-in-actual-clinical-practice
#8
Dae Hyung Woo, Kyeong Ok Kim, Da Eun Jeong, Yoon Jeong Nam, Si Hyung Lee, Byung Ik Jang, Tae Nyeun Kim
Background/Aims: Inadequate bowel preparation can result in prolonged procedure time and increased missed lesion and complication rates. This prospective study aimed to evaluate bowel preparation quality and identify the predictive factors for inadequate bowel preparation in actual clinical practice. Methods: We included 399 patients who underwent colonoscopy between June 2015 and July 2016. Using the Aronchick bowel preparation scale, we defined a score ≤2 as adequate preparation and a score >2 as inadequate preparation...
April 2018: Intestinal Research
https://www.readbyqxmd.com/read/29743842/a-simple-phenotypic-classification-for-celiac-disease
#9
Ajit Sood, Vandana Midha, Govind Makharia, B K Thelma, Shivalingappa S Halli, Varun Mehta, Ramit Mahajan, Vikram Narang, Kriti Sood, Kirandeep Kaur
Background/Aims: Celiac disease is a global health problem. The presentation of celiac disease has unfolded over years and it is now known that it can manifest at different ages, has varied presentations, and is prone to develop complications, if not managed properly. Although the Oslo definitions provide consensus on the various terminologies used in literature, there is no phenotypic classification providing a composite diagnosis for the disease. Methods: Various variables identified for phenotypic classification included age at diagnosis, age at onset of symptoms, clinical presentation, family history and complications...
April 2018: Intestinal Research
https://www.readbyqxmd.com/read/29743841/intraoperative-inspection-alone-is-a-reliable-guide-to-the-choice-of-surgical-procedure-for-enteroenteric-fistulas-in-crohn-s-disease
#10
Zhen Guo, Xingchen Cai, Ruiqing Liu, Jianfeng Gong, Yi Li, Lei Cao, Weiming Zhu
Background/Aims: Resection of the diseased segment and suture of the victim segment is recommended for enteroenteric fistula in Crohn's disease (CD). The main difficulty in this procedure remains reliable diagnosis of the victim segment, especially for fistulas found intraoperatively and inaccessible on endoscopic examination. We aimed to explore whether intraoperative inspection alone is reliable. Methods: Patients undergoing conservative surgery between 2011 and 2016 for enteroenteric fistulas complicating CD were identified from a prospectively maintained database...
April 2018: Intestinal Research
https://www.readbyqxmd.com/read/29743840/evaluation-of-the-drug-induced-lymphocyte-stimulation-test-for-diagnosing-mesalazine-allergy
#11
Daisuke Saito, Mari Hayashida, Taro Sato, Shintaro Minowa, Osamu Ikezaki, Tatsuya Mitsui, Miki Miura, Akihito Sakuraba, Tadakazu Hisamatsu
Background/Aims: Mesalazine is an effective drug for treating ulcerative colitis (UC), but causes allergic symptoms in a few cases. Therefore, the objective of this study was to evaluate the usefulness of the drug-induced lymphocyte stimulation test (DLST) for the diagnosis of mesalazine allergy. Methods: Patients with UC treated with mesalazine with or without a history of associated adverse events (AEs) were enrolled at Kyorin University Hospital from July 2016 to April 2017...
April 2018: Intestinal Research
https://www.readbyqxmd.com/read/29743839/is-clostridium-difficile-infection-a-real-threat-in-patients-with-ulcerative-colitis-a-prospective-multicenter-study-in-korea
#12
Dae Bum Kim, Kang-Moon Lee, Sang Hyoung Park, You Sun Kim, Eun Soo Kim, Jun Lee, Sung-Ae Jung, Geom Seog Seo, Ji Min Lee
Background/Aims: Clostridium difficile infection (CDI) has been reported to be a cause of flare-ups in patients with ulcerative colitis (UC). We evaluated the prevalence and clinical outcomes of CDI in patients with UC hospitalized for flare-ups. Methods: This was a prospective, multicenter study including 7 academic teaching hospitals in Korea. All consecutive patients with UC admitted for disease flare-up were enrolled. We detected the presence of CDI by using enzyme immunoassay, real-time polymerase chain reaction (RT-PCR) for toxin genes, and sigmoidoscopy...
April 2018: Intestinal Research
https://www.readbyqxmd.com/read/29743838/comparison-of-efficacy-of-once-daily-multimatrix-mesalazine-2-4-g-day-and-4-8-g-day-with-other-5-aminosalicylic-acid-preparation-in-active-ulcerative-colitis-a-randomized-double-blind-study
#13
Haruhiko Ogata, Tadashi Yokoyama, Seiichi Mizushima, Atsushi Hagino, Toshifumi Hibi
Background/Aims: This study compared the efficacy of multimatrix mesalazine 2.4 g/day and 4.8 g/day with controlled-release mesalazine 2.25 g/day. Methods: In this multicenter, randomized, double-blind study, 251 patients with mildly to moderately active ulcerative colitis received multimatrix mesalazine 2.4 g/day once daily (Multimatrix-2.4), 4.8 g/day once daily (Multimatrix-4.8), or controlled-release (time-dependent) mesalazine 2.25 g/day 3 times daily (Time-2...
April 2018: Intestinal Research
https://www.readbyqxmd.com/read/29743837/characterization-of-the-fecal-microbiota-differs-between-age-groups-in-koreans
#14
Sun-Young Kook, Yunjeong Kim, Ben Kang, Yon Ho Choe, Young-Ho Kim, Seokjin Kim
Background/Aims: Tens of trillions of microorganisms constitute the gut microbiota of the human body. The microbiota plays a critical role in maintaining host immunity and metabolism. Analyses of the gut microbial composition in Korea are limited to a few studies consisting of small sample sizes. To investigate the gut microbial community in a large sample of healthy Koreans, we analyzed the 16S ribosomal RNA of 4 representative bacterial genera Lactobacillus , Bifidobacterium , Bacteroides , and Clostridium ...
April 2018: Intestinal Research
https://www.readbyqxmd.com/read/29743836/tofacitinib-induction-and-maintenance-therapy-in-east-asian-patients-with-active-ulcerative-colitis-subgroup-analyses-from-three-phase-3-multinational-studies
#15
Satoshi Motoya, Mamoru Watanabe, Hyo Jong Kim, Young Ho Kim, Dong Soo Han, Hirotoshi Yuasa, Junichi Tabira, Naoki Isogawa, Shoko Arai, Isao Kawaguchi, Toshifumi Hibi
Background/Aims: Tofacitinib is an oral, small-molecule Janus kinase inhibitor being investigated for ulcerative colitis (UC). In OCTAVE Induction 1 and 2, patients with moderately to severely active UC received placebo or tofacitinib 10 mg twice daily (BID) for 8 weeks. Clinical responders in OCTAVE Induction were re-randomized to 52 weeks' therapy with placebo, tofacitinib 5 mg BID, or tofacitinib 10 mg BID. Methods: We conducted post-hoc efficacy and safety analyses of East Asian patients in OCTAVE Induction 1 and 2 and OCTAVE Sustain...
April 2018: Intestinal Research
https://www.readbyqxmd.com/read/29743835/trough-level-of-infliximab-is-useful-for-assessing-mucosal-healing-in-crohn-s-disease-a-prospective-cohort-study
#16
Akihiro Koga, Toshiyuki Matsui, Noritaka Takatsu, Yasumichi Takada, Masahiro Kishi, Yutaka Yano, Takahiro Beppu, Yoichiro Ono, Kazeo Ninomiya, Fumihito Hirai, Takashi Nagahama, Takashi Hisabe, Yasuhiro Takaki, Kenshi Yao, Hirotsugu Imaeda, Akira Andoh
Background/Aims: Decreased trough levels of infliximab (TLI) and antibodies to infliximab (ATI) are associated with loss of response (LOR) in Crohn's disease. Two prospective studies were conducted to determine whether TLI or ATI better correlates with LOR (Study 1), and whether TLI could become a predictor of mucosal healing (MH) (Study 2). Methods: Study 1 was conducted in 108 patients, including those with LOR and remission to compare ATI and TLI in discriminating the 2 conditions based on receiver operating characteristic (ROC) curve analyses...
April 2018: Intestinal Research
https://www.readbyqxmd.com/read/29743834/characteristics-and-management-of-patients-with-inflammatory-bowel-disease-between-a-secondary-and-tertiary-hospitals-a-propensity-score-analysis
#17
Ki Hwan Song, Eun Soo Kim, Yoo Jin Lee, Byung Ik Jang, Kyeong Ok Kim, Sang Gyu Kwak, Hyun Seok Lee
Background/Aims: This study aimed to compare the clinical characteristics and management patterns of inflammatory bowel disease (IBD) patients in a secondary hospital (SH) with those in tertiary referral centers (TRC). Methods: Data from IBD patients in SH and 2 TRCs were retrospectively reviewed. The cumulative thiopurine use rate was compared between hospitals after controlling for different baseline characteristics using propensity score matching. Results: Among the total of 447 patients with IBD, 178 Crohn's disease (CD) and 269 ulcerative colitis (UC) patients were included...
April 2018: Intestinal Research
https://www.readbyqxmd.com/read/29743833/why-is-it-so-difficult-to-evaluate-faecal-microbiota-transplantation-as-a-treatment-for-ulcerative-colitis
#18
REVIEW
Natalie Grace Fairhurst, Simon P L Travis
Faecal microbiota transplantation (FMT) has recently re-emerged as a viable therapeutic option for colonic disorders. Its efficacy has been proved in the treatment of Clostridium difficile infection which has encouraged research into the use of FMT for other disorders involving gut dysbiosis, such as ulcerative colitis (UC), a chronic inflammatory disease characterized by relapsing and remitting colonic inflammation. Although the FMT protocol for C. difficile treatment is well established, there are numerous additional factors to consider when applying FMT to treat inflammatory diseases...
April 2018: Intestinal Research
https://www.readbyqxmd.com/read/29743832/management-of-inflammatory-bowel-disease-in-older-persons-evolving-paradigms
#19
REVIEW
Saurabh Kedia, Jimmy K Limdi, Vineet Ahuja
The incidence and prevalence of inflammatory bowel disease (IBD) is increasing, and considering the aging population, this number is set to increase further in the future. The clinical features and natural history of elderly-onset IBD have many similarities with those of IBD in younger patients, but with significant differences including a broader differential diagnosis. The relative lack of data specific to elderly patients with IBD, often stemming from their typical exclusion from clinical trials, has made clinical decision-making somewhat challenging...
April 2018: Intestinal Research
https://www.readbyqxmd.com/read/29743831/evidence-based-consensus-on-opportunistic-infections-in-inflammatory-bowel-disease-republication
#20
REVIEW
(no author information available yet)
Inflammatory bowel disease (IBD) patients are a high-risk population for opportunistic infections. The IBD group of the Chinese Society of Gastroenterology of the Chinese Medical Association organized an expert group to discuss and develop this consensus opinion. This consensus opinion referenced clinical study results from China and other countries to provide guidance for clinical practices. Eight major topics, including cytomegalovirus infection, Epstein-Barr virus infection, viral hepatitis, bacterial infection, Mycobacterium tuberculosis infection, fungal infection, parasitic infection, and vaccines were introduced in this article...
April 2018: Intestinal Research
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