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Dermatology Reports

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https://www.readbyqxmd.com/read/26734122/exploring-valrubicin-s-effect-on-propionibacterium-acnes-induced-skin-inflammation-in-vitro-and-in-vivo
#1
Louise Rottboell, Sarah de Foenss, Kenneth Thomsen, Helle Christiansen, Stine M Andersen, Tomas N Dam, Cecilia Rosada, Karin Stenderup
Acne is a common skin disease involving colonization with Propionibacterium acnes (P. acnes), hyperproliferation of the follicular epithelium and inflammatory events. Valrubicin is a second-generation anthracycline, non-toxic upon contact, and available in a topical formulation. Valrubicin's predecessor doxorubicin possesses antibacterial effects and previously we demonstrated that valrubicin inhibits keratinocyte proliferation and skin inflammation suggesting beneficial topical treatment of acne with valrubicin...
December 3, 2015: Dermatology Reports
https://www.readbyqxmd.com/read/26734121/giant-condyloma-acuminate-due-to-human-papillomavirus-type-16-in-an-infant-successfully-treated-with-topical-imiquimod-therapy
#2
Meltem Dinleyici, Nurhan Saracoglu, Makbule Eren, Ömer Kiliç, Evrim Ciftci, Ener Cagri Dinleyici, Cigdem Sag, Ates Kara
Anogenital warts related to human papillomavirus (HPV) have been observed in children. Definition of the transmission mode, therapy, and follow-up for long term potential complications is important. A 27-month old girl was admitted with multiple pedunculated red-purple colored cauliflower-like lesions of 1.5 years duration. Clinical/histopathological and microbiological diagnosis was condyloma acuminate due to HPV type 16. After 12 weeks of imiquimod 5% cream application (pea-sized) overnight three times per week, the perianal warts had completely disappeared...
December 3, 2015: Dermatology Reports
https://www.readbyqxmd.com/read/26734120/subclinical-onychomycosis-in-patients-with-type-ii-diabetes
#3
Amira Elbendary, Amira El Tawdy, Naglaa Zaki, Mostafa Alfishawy, Amr Rateb
Fungal organisms could be present in the nail without any clinical manifestations. As onychomycosis in diabetics has more serious complications, early detection of such infection could be helpful to prevent them. We aim in this study to assess the possibility of detecting subclinical onychomycosis in type II diabetic patients and addressing possible associated neuropathy. A cross sectional, observational study included patients with type II diabetes with normal big toe nail. All were subjected to nail clipping of the big toe nail, followed by staining with Hematoxylin and Eosin and Periodic-Acid-Schiff (PAS) stains and examined microscopically...
December 3, 2015: Dermatology Reports
https://www.readbyqxmd.com/read/26734119/severity-of-depression-and-anxiety-in-patients-with-alopecia-areata-in-bandar-abbas-iran
#4
Shahram Baghestani, Shahram Zare, Seyed Hamzeh Seddigh
Alopecia areata (AA) is a chronic disease which esthetic outcomes may result in deep effects on mental disorders of patients. In this case-control study, we compared the mental health of 68 patients diagnosed with AA with 68 healthy individuals using Hamilton anxiety and depression rating scales. There were significant differences between the case and control groups regarding the prevalence of anxiety and depression. The means of anxiety scores in cases and control group were 12.76±7.21 vs 8.54±6.37, P=0...
December 3, 2015: Dermatology Reports
https://www.readbyqxmd.com/read/26236448/an-epidemiological-study-of-97-cases-of-primary-cicatricial-alopecia-in-iran
#5
Akram Beheshtiroy, Fatemeh Hajmanoochehri, Fahim Hossienghamar
Cicatricial alopecia can produce major psychosocial disturbance. This study aimed to evaluate epidemiological features of primary cicatricial alopecia (PCA). Epidemiological and histological types of scarring alopecia were determined. The chi-squared test and t-test were performed to examine the relationship between different variables using SPSS 16. A total of 97 cases, 35 (36.1%) men and 62 (63.9%) women, with an average age of 37 (SD=12.7), were included in this study. The female/male (F/M) ratio was 1.7:1 for total cases, 1...
May 21, 2015: Dermatology Reports
https://www.readbyqxmd.com/read/26236447/the-use-of-chemotherapeutics-for-the-treatment-of-keloid-scars
#6
REVIEW
Christopher David Jones, Luke Guiot, Mike Samy, Mark Gorman, Hamid Tehrani
Keloid scars are pathological scars, which develop as a result of exaggerated dermal tissue proliferation following cutaneous injury and often cause physical, psychological and cosmetic problems. Various theories regarding keloidogenesis exist, however the precise pathophysiological events remain unclear. Many different treatment modalities have been implicated in their management, but currently there is no entirely satisfactory method for treating all keloid lesions. We review a number of different chemotherapeutic agents which have been proposed for the treatment of keloid and hypertrophic scars while giving insight into some of the novel chemotherapeutic drugs which are currently being investigated...
May 21, 2015: Dermatology Reports
https://www.readbyqxmd.com/read/26236446/treatment-modalities-of-necrobiosis-lipoidica-a-concise-systematic-review
#7
REVIEW
Amir Feily, Shadi Mehraban
Necrobiosis lipoidica (NL) is a rare inflammatory granulomatous skin disorder closely associated with diabetes mellitus. The aim of this paper is to review and discuss all the treatment modalities proposed and tested for this disease. A systematic review of the existing literature was conducted to investigate all the available data and summarize all the clinical trials, case reports and original articles on NL. Two major databases (PubMed and Google Scholar) were used. We have examined about 70 articles. Numerous treatment modalities have been currently investigated to compare recalcitrant NL...
May 21, 2015: Dermatology Reports
https://www.readbyqxmd.com/read/26236445/two-episodes-of-cutaneous-non-tuberculous-mycobacterial-infection-in-a-patient-with-psoriasis
#8
Wai Sze Agnes Chan, Shang-Ian Tee, Nisha Su Yien Chandran, Jiun Yit Pan
Non-tuberculous mycobacteria (NTM) are a group of environmental pathogens, which cause a broad spectrum of disease. The incidence of NTM infection is increasing, especially in immunocompromized patients. The past three decades also saw a rapid increase in the incidence of NTM infection involving otherwise healthy subjects. We report a case of cutaneous NTM infection in a 79-year-old Chinese woman, who was receiving methotrexate for psoriasis. Mycobacterial culture grew Mycobacterium abscessus, and the lesions cleared with a combination of oral clarithromycin, ciprofloxacin and doxycycline...
May 21, 2015: Dermatology Reports
https://www.readbyqxmd.com/read/25918620/treatment-of-primary-cutaneous-anaplastic-large-cell-lymphoma-with-superficial-x-rays
#9
Malene E Jepsen, Robert Gniadecki
The optimal radiation schedule for primary cutaneous anaplastic lymphoma (PCALCL) has not been investigated. We report here satisfactory outcomes of low-dose (16-20 Gy, 3-5 fractions), superficial X-ray radiation (40-50 kV) in a series of 10 patients with PCALCL. Only 1 patient developed a local relapse during the median observation time of 25 months; complete remission was recorded in the other patients. This observation indicates that superficial, low dose X-ray therapy may provide a cost-effective alternative to the traditional 35-45 Gy schedules...
March 16, 2015: Dermatology Reports
https://www.readbyqxmd.com/read/25918619/delayed-immune-mediated-adverse-effects-to-hyaluronic-acid-fillers-report-of-five-cases-and-review-of-the-literature
#10
Ora Bitterman-Deutsch, Leonid Kogan, Faris Nasser
Hyaluronic acid (HA) fillers in cosmetic medicine have been considered relatively safe, though fillers used in European countries and throughout the world are not necessarily approved by the Food and Drug Administration. As their use continues to expand worldwide, physicians in a wide range of medical specialties are authorized to perform HA injections, including general medicine practitioners and even dentists. An increasing number of reports have appeared regarding side effects to these products. It is now known that reactions to Hyaluronic acid are related not only to technical faults of the injections, but also to immune responses, including delayed hypersensitivity and granulomatous reactions...
March 16, 2015: Dermatology Reports
https://www.readbyqxmd.com/read/25918618/severe-scratcher-reaction-an-unknown-health-hazard
#11
Carsten Sauer Mikkelsen, Helene Ringe Holmgren, Kristian Bakke Arvesen, Reem Dina Jarjis, Gudjon Leifur Gunnarsson
Tattoos are well known to cause skin problems and the number of reported adverse reactions after tattooing has increased. Illegally imported tattoo ink is unrestrained and can contain unknown ingredients and contamination thereby posing a serious health hazard. We present a case illustrating the risk of pronounced phototoxic allergic reaction and other severe complications after using home kit tattoo ink.
March 16, 2015: Dermatology Reports
https://www.readbyqxmd.com/read/25918617/efficacy-of-intravenous-immunoglobulin-monotherapy-in-patients-with-cutaneous-lupus-erythematosus-results-of-proof-of-concept-study
#12
Christa Ky, Brian Swasdibutra, Shaadi Khademi, Sheetal Desai, Vivian Laquer, Sergei A Grando
Cutaneous lupus erythematosus (CLE) is a chronic inflammatory autoimmune skin disease. Evidence-based therapy for CLE is lacking in the most part. Intravenous immunoglobulin (IVIg) is being increasingly utilized as off-label therapy for a variety of autoimmune and inflammatory conditions, especially in dermatology. The usefulness of IVIg in CLE is not well established. The goal of the present study was to obtain the proof-of-concept evidence that IVIg can control acute CLE and thus replace current systemic immunosuppressive therapy that causes severe side effects and adverse reactions...
March 16, 2015: Dermatology Reports
https://www.readbyqxmd.com/read/25918616/onychomycosis-by-syncephalastrum-racemosum-case-report-from-kerala-india
#13
Sabitha Baby, T G Ramya, R K Geetha
We report a rare case of onychomycosis caused by Syncephalastrum racemosum in a 50-year-old diabetic patient. The patient's nail was surgically excised and thorough debridement was done. The patient was successfully treated with topical nystatin.
March 16, 2015: Dermatology Reports
https://www.readbyqxmd.com/read/25386331/combined-therapeutic-use-of-oral-alitretinoin-and-narrowband-ultraviolet-b-therapy-in-the-treatment-of-hailey-hailey-disease
#14
Kaitlin A Vanderbeck, Lyne Giroux, Nirosha J Murugan, Lukasz M Karbowski
Hailey-Hailey disease (HHD) is a chronic familial bullous disease characterized by recurrent blisters and erosions typically at friction-prone areas of the body accompanied by acantholysis upon histologic examination. There are a number of therapies used in the management of HHD. Its symptoms have been effectively treated with antimicrobial therapies, corticosteroids and other agents such as cyclosporine and prednisone. However, such treatments are not always effective. Therefore, there is a need for new treatments for the management of HHD...
February 17, 2014: Dermatology Reports
https://www.readbyqxmd.com/read/25386330/mucinous-eccrine-carcinoma-of-the-eyelid-re-emphasizing-the-need-for-awareness-of-rare-lesions
#15
Kiran Krishne Gowda, Parimal Agarwal, Amanjit Bal
We report here the case of a man presenting with mucinous eccrine carcinoma (MEC) involving eyelid. This is a rare adencocarcinoma of the skin that originates from the deepest portion of eccrine sweat duct. The aim of our paper is to underline the importance of distinguishing MEC from metastatic carcinomas of the skin, making clinicians aware that what seems to be a harmless benign lesion may be a malignant one.
February 17, 2014: Dermatology Reports
https://www.readbyqxmd.com/read/25386329/progress-in-psoriasis-therapy-via-novel-drug-delivery-systems
#16
REVIEW
Nitha Vincent, Devi D Ramya, Hari Bn Vedha
Psoriasis is a lifelong condition which is caused by the negative signals produced by immune system, which leads to hyper proliferation and other inflammatory reactions on the skin. In this case, keratinocytes which are the outermost layer of skin possess shortened life cycle and results in the alteration of desquamation process where the cytokines will come out through lesions of affected patients and as a result, scaling marks appears on the skin. These conditions may negatively affect the patient's quality of life and lead to psychosocial stress...
February 17, 2014: Dermatology Reports
https://www.readbyqxmd.com/read/25386328/familial-amyloidosis-cutis-dyschromica-in-three-siblings-report-from-indonesia
#17
Melyawati Hermawan, Rahadi Rihatmadja, Sondang Pandjaitan Sirait
Amyloidosis cutis dyschromica (ACD) is an extremely rare type of primary cutaneous amyloidosis. To date there are fewer than 40 published cases worldwide; some were reported affecting several family members. Its resemblance to other common pigmentation disorders makes it rarely recognized at first sight. Our patient, the 12-year-old firstborn son of non-consanguineous parents presented with generalized mottled pigmentation starting from lower extremities. His siblings suffered from similar condition. The clue for diagnosis is the amyloid deposition in the papillary dermis...
February 17, 2014: Dermatology Reports
https://www.readbyqxmd.com/read/25386327/angina-bullosa-hemorrhagica-report-of-11-cases
#18
Julieta Ruiz Beguerie, Silvina Gonzalez
Angina bullosa hemorrhagica is a rare and benign disorder, usually localized in the subepithelial layer of the oral, pharyngeal and esophageal mucosa. The lesions are characterized by their sudden onset. They appear as a painless, tense, dark red and blood-filled blister in the mouth that rapidly expand and rupture spontaneously in 24-48 hours. The underlying etiopathology remains ill defined, although it may be a multifactorial phenomenon including diabetes, and steroid inhalers. The condition is not attributable to blood dyscrasias, nor other vesicular-bullous disorders...
February 17, 2014: Dermatology Reports
https://www.readbyqxmd.com/read/25386326/delayed-diagnosis-of-adult-indolent-systemic-mastocytosis
#19
Carsten Sauer Mikkelsen, Andrew Nybo, Kristian Bakke Arvesen, Johan Holk-Poulsen
Systemic mastocytosis (SM) is a rare, heterogeneous disorder characterized by infiltration and accumulation of mast cells within multiple organs, most commonly the skin. Given the rarity of the disease and the fact that many of its symptoms are shared by more common disorders, a diagnosis may be delayed or hindered. These patients have an elevated risk of developing potentially life-threatening anaphylactoid reactions, thus underscoring the importance of keeping SM in mind as a differential diagnosis when a patient presents with chronic, itchy skin lesions and a history of multiple allergic reactions to bites, drugs, and anesthesia...
February 17, 2014: Dermatology Reports
https://www.readbyqxmd.com/read/25386325/saree-cancer-in-indian-woman-treated-successfully-with-multimodality-management
#20
Unmesh Vidyadhar Takalkar, Shilpa Balaji Asegaonkar, Pushpa Kodlikeri, Ujwala Kulkarni, Virendrakumar Borundiya, Suresh H Advani
Saree is a common, traditional garment of Indian women, wrapped around the waist is tightened by a thick cord and with one end draped over the shoulder. Tight knot in the same place, sweat, soiling and continuous use can cause pigmentation, scaling of the waist and even transform to malignancy. We present here a case of saree cancer successfully managed with multimodality therapy. A 50-year-old woman was referred to our hospital (India) for itching and non-healing ulcerative lesion on waistline. She was wearing saree continuously for 34 years with knot at the same place...
February 17, 2014: Dermatology Reports
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