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Turkish Journal of Medical Sciences

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https://www.readbyqxmd.com/read/29152952/lack-of-mir143-mir145-mir184-mir1224-and-mir29b1-mutations-in-keratoconus-pathogenesis
#1
LETTER
Nurullah Çağıl, Nagihan Uğurlu, Cemil Yunus Şahan, Serhat Sevli
No abstract text is available yet for this article.
November 13, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/29152951/lipid-emulsion-and-verapamil-toxicity
#2
LETTER
Ju-Tae Sohn
No abstract text is available yet for this article.
November 13, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/29152950/investigation-of-class-d-beta-lactamases-causing-carbapenem-resistance-in-clinical-acinetobacter-baumannii-isolates
#3
Iskandar Davandeh, Bayrı Eraç, Sabire Şöhret Aydemir
Background/aim: Acinetobacter baumannii is an important causative agent of nosocomial infections, and carbapenems have been frequently used in the treatment of these infections. This study was designed to investigate the prevalence of primary carbapenem hydrolyzing oxacillinase (CHO) types in clinical A. bumannii strains. Materials and methods: Minimum inhibitory concentration (MIC) values of 76 imipenem nonsusceptible A. baumannii strains, isolated from a tertiary care hospital, were determined by microdilution method...
November 13, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/29152949/effects-of-valproic-acid-on-sympathetic-activity-and-left-ventricularmyocardial-remodelling-in-rats-during-pressure-overload
#4
Yang Liu, Siyu Li, Zhigang Zhang, Zhanjun Lv, Huijie Jiang, Xiao Tan, Fengquan Liu
Background/aim: Pressure overload induces cardiac remodelling and results in heart failure. Enhanced sympathetic outflow participates in the development of cardiac remodelling for the duration of pressure overload as an independent factor. Valproic acid has recently been shown to reduce neuronal injury and have antiinflammatory and antiapoptotic effects as a histone deacetylase inhibitor. We speculate that the drug plays a specific role in alleviating cardiac remodelling by inhibiting sympathetic activity. Materials and methods: Surgery of partial abdominal aortic constriction was performed on male Sprague-Dawley rats...
November 13, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/29152948/exogenous-erythropoietin-aggravates-retinal-neovascularizationin-a-murine-model-of-proliferative-retinopathy
#5
Ning Yang, Wenxi Zhang, Tao He, Yiqiao Xing
Background/aim: Erythropoietin (EPO) has been proven recently to be a critical mediator in retinal neovascularization (RNV). Previous studies have indicated that the use of recombinant human EPO (rEPO) is a high risk factor in the development of retinopathy of prematurity. In this study, we aimed to investigate the effect of rEPO administration on RNV and its underlying mechanism in a mouse model of oxygen-induced retinopathy (OIR). Materials and methods: A murine model of OIR was used to generate RNV. After daily intraperitoneal injection of rEPO from postnatal day 12 (P12), mice were euthanized at P17...
November 13, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/29152946/the-effects-of-mesenchymal-stem-cells-on-the-structure-and-contractile-force-of-the-carotid-artery-in-a-rat-aneurysm-model
#6
(no author information available yet)
Background/aim: An aneurysm is a pathological enlargement of an artery characterized by the thinning of the elastic fiber layer in the tunica media. Because the aneuritic artery wall is weakened, these vessels can rupture and cause serious bleeding. Surgical methods are often used for the treatment of aneurysms. However, cell-based therapies are less invasive and potentially safer alternatives. In this study, the therapeutic efficacy of rat adipose tissue-derived mesenchymal stem cells (MSCs) was investigated in a new carotid artery aneurysm model...
November 13, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/29152945/dna-methylation-of-the-prestin-gene-and-outer-hair-cell-electromotileresponse-of-the-cochlea-in-salicylate-administration
#7
(no author information available yet)
Background/aim: Activity of the prestin gene may have a role in the pathogenesis of salicylate-induced ototoxicity. We investigated DNA methylation for prestin gene exon 1 in salicylate-injected guinea pigs.Materials and methods: Fifteen guinea pigs (30 ears) underwent audiological evaluation including 1000 Hz probe-tone tympanometry and a distortion product otoacoustic emission (DPOAE) test. The animals were randomly divided into three groups. Groups 2 (8 ears) and 3 (14 ears) were injected with intramuscular saline and sodium salicylate (200 mg/kg), respectively twice daily for 2 weeks...
November 13, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/29152944/combined-oral-supplementation-of-chromium-picolinate-docosahexaenoic-acid-and-boron-enhances-neuroprotection-in-rats-fed-a-high-fat-diet
#8
Cemal Orhan, Nurhan Şahin, Zeynep Tuzcu, James R. Komorowski, Kazım Şahin
Background/aim: A novel complex of a nutritional supplement (CDB) contains chromium picolinate (CrPic), phosphatidylserine (PS), docosahexaenoic acid (DHA), and boron (B). The present study aimed to investigate the effects of CDB on the metabolic profile and memory acquisition in rats fed a high-fat diet (HFD). Materials and methods: Male Wistar rats were divided into six groups and received either a regular diet or HFD supplemented with or without different levels of CDB (0, 11, or 22 mg/kg BW). Results: Rats fed the HFD had greater glucose, insulin, lipid profile, and serum malondialdehyde concentrations, but lower serotonin and tryptophan in the serum and brain and lower Cr concentrations in serum, kidney, brain, and liver (P < 0...
November 13, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/29152942/effects-of-positive-end-expiratory-pressure-on-intracranial-pressure-during-pneumoperitoneum-and-trendelenburg-position-in-a-porcine-mode
#9
Nurdan Bedirli, Gökçen Emmez, Yusuf Ünal, Mehmet Tönge, Hakan Emmez
Background/aim: This study was undertaken to evaluate the effects of positive end-expiratory pressure (PEEP) levels on intracranial pressure (ICP) and cerebral perfusion pressure (CPP) and to determine the appropriate PEEP level during steep Trendelenburg position combined with pneumoperitoneum.Materials and methods: Ten pigs were included in this study. Pneumoperitoneum and Trendelenburg position were maintained and PEEP titration was initiated. Arterial pressure, heart rate, arterial blood gas, ICP, and CPP were recorded at the following time points: baseline (T0), 30 min after positioning and pneumoperitoneum (T1), PEEP 5 (T2), PEEP 10 (T3), PEEP 15 (T4), and PEEP 20 (T5)...
November 13, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/29152941/the-histopathological-and-stereological-assessment-of-the-effect-of-topically-administered-leptin-on-cerebral-vasospasm-in-an-experimental-subarachnoid-hemorrhage-model
#10
Cem Demirel, Cengiz Çokluk, Abdurrahman Aksoy, Kerameddin Aydın, Mehmet Emin Önger, Enis Kuruoğlu, Abdullah Hilmi Marangoz, Ömür Gülsüm Deniz, Süleyman Kaplan
Background/aim: Cerebral vasospasm is a term that refers to prolonged, slowly progressing but reversible pathological narrowing of cerebral arteries occurring several days after subarachnoid hemorrhage (SAH), usually accompanied by a decrease in perfusion distal to the affected artery. Leptin is an endogenous polypeptide hormone that can be carried freely and bound to protein in the blood. Materials and methods: We investigated the superiority of topical application of leptin that may make a contribution to the development of new treatment modalities for unconscious patients in brain injury intensive care units and its preventive effect, which is considered to have multifactorial pathogenesis on cerebral vasospasm occurring after SAH via stereological studies of the basilar artery...
November 13, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/29151338/genotype-distribution-of-mycobacterium-tuberculosis-in-theaegean-region-and-associated-demographic-factors
#11
Cengiz Çavuşoğlu, Fethiye Ferda Yılmaz, İsabel Raika Durusoy Onmuş, Tuğba Bozdemir, Hüseyin Taşlı, Mine Hoşgör Limoncu
Background/aim: The Aegean Region is the second-ranking region in Turkey according to the Human Development Index and population density and it hosts 1/8 of Turkey's population. İzmir is the largest city of the region, receiving internal migration both from inside and outside the region. The tuberculosis incidence in İzmir is lower than overall in Turkey: 17.7/100,000 in 2011. Our aims were to determine genotypes of Mycobacterium tuberculosis isolates; to explore possible associations between genotypes with case-demographic data, clinical presentation, and antimicrobial susceptibility patterns; and to determine variations in genotype distribution of strains isolated in Ege University Hospital, İzmir...
November 13, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/29151337/coexistence-of-idiopathic-granulomatous-mastitis-and-erythemanodosum-successful-treatment-with-corticosteroids
#12
Murat Akın, Harun Karabacak, Güldal Esendağlı, Aydın Yavuz, Serap Gültekin, Kürşat Dikmen, Hasan Bostancı
Background/aim: Idiopathic granulomatous mastitis (IGM) is a rare, chronic inflammatory disease of the breast. Erythema nodosum (EN) is a rare extramammary manifestation of IGM. The purpose of this study is to determine the clinical and demographic characteristics of 11 IGM and EN patients and to evaluate the efficacy of methylprednisolone treatment. Materials and methods: In our series, ten patients had EN bilaterally, whereas one patient had a lesion of the right pretibial area. The mean age of the patients was 35...
November 13, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/29151336/efficacy-of-bispectral-index-monitoring-for-prevention-of-anestheticawareness-and-complications-during-oocyte-pick-up-procedure
#13
Aykut Urfalıoğlu, Mahmut Arslan, Murat Bakacak, Hafize Öksüz, Ömer Faruk Boran, Gözen Öksüz
Background/aim: This study was planned by considering that the use of bispectral index (BIS) monitoring ensures sufficient depth of anesthesia and avoids anesthetic awareness and patient movement in the oocyte pick-up (OPU) procedure.Materials and methods: Ninety-eight patients undergoing OPU were randomly divided into 2 groups as the control group (n = 48) and BIS group (n = 50). After propofol and remifentanil induction, the control group was given additional propofol according to reaction response, while the BIS group was given propofol at BIS values of 60 and above with the aim that BIS values be 40?60...
November 13, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/29151335/comparison-of-tidal-volume-and-deep-breath-preoxygenation-techniquesundergoing-coronary-artery-bypass-graft-surgery-effects-of-hemodynamicresponse-and-arterial-oxygenation
#14
Zafer Taş, Tülay Hoşten, Alparslan Kuş, Sevim Cesur, Neşe Türkyılmaz, Ahmet Arıkan, Zeynep Mine Solak
Background/aim: Different techniques exist for the preoxygenation of patients that will be operated on under general anesthesia. Preoxygenation with the deep breath (DB) method may affect cardiovascular stability, which is crucial for coronary artery bypass graft (CABG) patients. In this study, we aimed to compare the effects of the 3 min TVB preoxygenation technique and 1 min 8DBs technique on hemodynamic response and arterial oxygenation in patients with normal ejection fraction that were scheduled for elective CABG surgery...
November 13, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/29151334/investigation-of-glucocorticoid-receptor-and-calpain-10-gene-polymorphisms-in-turkish-patients-with-type-2-diabetes-mellitus
#15
Naciye Selcen Bayramcı, Leyla Açık, Çağdaş Kalkan, İlhan Yetkin
Background/aim: We proposed to investigate the role of calpain-10 (CAPN10) gene single nucleotide polymorphism (SNP)-19 and SNP-44 and glucocorticoid receptor (NR3C1) gene N363S polymorphisms in Turkish patients with type 2 diabetes mellitus (T2DM).Materials and methods: Peripheral blood samples were obtained from 125 patients with T2DM and 112 healthy volunteers. Genotyping was carried out by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Results: There were no statistically significant differences found between the allele and genotype frequencies of CAPN10 SNP-19, CAPN10 SNP-44, and NR3C1 N363S polymorphisms and T2DM development (P > 0...
November 13, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/29151333/isolated-sphenoid-sinus-pathologies-a-series-of-40-cases
#16
Fakih Cihat Eravcı, Alper Ceylan, Mehmet Göcek, Fikret İlerı, Süleyman Sabri Uslu, Metin Yılmaz, Yusuf Kızıl
Background/aim: Isolated sphenoid sinus-derived lesions are rare and generally present with unclear symptoms. We are sharing our experience to be mindful of such lesions in differential diagnosis and to help accomplish successful treatment while avoiding revisions and complications.Materials and methods: Data from patients who underwent isolated sphenoid sinus surgeries (ISSs) were retrospectively extracted from the period of January 2005 to August 2015. Demographic data, chief complaints and presenting symptoms, imaging findings, surgical management, and results were evaluated...
November 13, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/29151332/the-relationship-between-the-degree-of-skin-fibrosis-by-sonoelastography-and-the-degree-of-pulmonary-involvement-in-scleroderma
#17
Songül Çildağ, Mehmet Burak Çildağ
Background/aim: This study aimed to assess the relationship between skin fibrosis as determined by sonoelastography and the degree of pulmonary involvement as determined by high-resolution computed tomography (HRCT) in patients with diffuse cutaneous systemic sclerosis (dcSSc).Materials and methods: This prospective study included 40 patients with dcSSc. All patients with HRCT scans underwent conventional ultrasonography and sonoelastography to determine skin thickness and degree of fibrosis. The degree of fibrosis was classified according to color-scale sonoelastography...
November 13, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/29151331/polymorphisms-of-cancer-related-genes-and-risk-of-multipleprimary-malignancies-involving-colorectal-cancer
#18
Peiguo Cao, Li Yu, Anshan Wu, Jingjing Li, Ling Liu, Chunlan Liu, Jianda Zhou, Ke Cao, Chengxian Guo
Background/aim: This study aimed to investigate the relationship between single nucleotide polymorphisms (SNPs) of cancer-related genes and the risk of multiple primary malignancies involving colorectal cancer.Materials and methods: We collected tissue samples from 22 multiple primary cancer patients with primary colorectal cancer and performed genotyping assay for 116 SNP loci from 62 genes encoding peptides functioning in various signaling pathways using the DNA MassARRAY system. The chi-square test was used to compare the differences in base frequencies between patients and a control Chinese population from HapMap through the NCBI database...
November 13, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/29151330/analysis-of-recurrent-urethral-strictures-due-to-iatrogenic-urethral-trauma
#19
Fuat Kızılay, Adnan Şimşir, Ceyhun Özyurt
Background/aim: We aimed to analyze the effects of stricture location, etiology, age, and catheterization time on recurrence rate and recurrence time in patients who underwent direct vision internal urethrotomy (DVIU) for urethral strictures. Materials and methods: Patients were divided into three groups according to the location of the stricture: penile urethra, membranous urethra, and prostatic urethra strictures. Patients were also divided into three groups according to etiologic factors: strictures secondary to endoscopic procedures, urethral catheterization, and open or radical prostatectomy (anastomotic strictures were included in this group)...
November 13, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/29151329/epidemiology-and-analysis-of-invasive-fungal-infections-in-patients-withhematological-malignancies-a-single-center-real-life-experience
#20
Nur Soyer, Hatice Demet Kiper Ünal, Filiz Vural, Fahri Şahin, Mahmut Töbü, Ayhan Dönmez, Murat Tombuloğlu, Bilgin Arda, Güray Saydam
Background/aim: Invasive fungal infection (IFI) causes morbidity and mortality among patients with hematological malignancies. We evaluated the incidence and treatment characteristics of IFIs between October 2012 and December 2013. Materials and methods: Patients who received chemotherapy or stem cell transplantation were retrospectively evaluated. Fungal infections were classified according to EORTC criteria.Results: Prophylaxis and antifungal therapy were given in 30.5% and 23.6% of 522 chemotherapy courses, respectively...
November 13, 2017: Turkish Journal of Medical Sciences
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