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Turkish Journal of Medical Sciences

Servet Yolbaş, Ahmet Yıldırım, Ahmet Tektemur, Zulfinaz Betül Çelik, Ebru Önalan Etem, İbrahim Hanifi Özercan, Mehmet Mustafa Akın, Süleyman Serdar Koca
Background/aim: The Wnt/ß-catenin pathway has important biological activities, including the differentiation of cells and joint formations. The aim of our study was to determine the effect of paricalcitol on experimentally induced arthritis. Materials and methods: Type II collagen combined with Freund's adjuvant was applied to induce arthritis in Wistar albino female rats. Paricalcitol (0.3 μg/kg daily) was subcutaneously injected starting 1 day after collagen applications (prophylactic group) or 1 day after the onset of arthritis (therapeutic group), until day 29...
October 31, 2018: Turkish Journal of Medical Sciences
Zahide Küçük, Uğurkan Erkayıran, Muzaffer Çaydere, Damla Kayaalp, Deniz Karca Altıncaba
Objectives: We observed the efficacy of melatonin in preventing ovarian tissue damage in rats exposed to magnetic fields. Materials and methods: Forty rats were divided into four treatment groups: Group 1, control group (n = 10); Group 2, melatonin administration only (n = 10); Group 3, magnetic field exposure only (n = 10); Group 4, magnetic field exposure with melatonin administration (n = 10). The magnetic field was applied at a dose of 20 μT for 30 min/day for 10 days. Melatonin was orally administered at a dose of 10 mg/kg...
October 31, 2018: Turkish Journal of Medical Sciences
Demet Özkaramanlı Gür, Ozcan Gür, Selami Gürkan
Background/aim: Esmolol and amiodarone are two most commonly used antiarrhythmic drugs in coronary artery bypass grafting (CABG) surgery. Nevertheless, blockade of beta-2 receptors by increasing doses raise concerns about possible vasospasms. We studied the vasoactive effects of amiodarone and esmolol on left internal mammary artery (LIMA), radial artery (RA), and saphenous vein (SV) grafts. Materials and methods: After determining the presence of functional smooth muscle and endothelial layers, the responses of submaximally preconstricted graft samples were recorded in a tissue bath system...
October 31, 2018: Turkish Journal of Medical Sciences
Reyhan Yiş, Mine Doluca
Background/aim: The identification of Candida species isolated from clinical specimens provides information about antifungal susceptibility and sheds light on the choice of empirical treatment. In the present study, restriction enzyme analysis of C. albicans and non-albicans Candida species previously identified by conventional methods was done to evaluate the utility of restriction enzyme analysis for more rapid and reliable identification of Candida species. Materials and methods: A total of 146 Candida strains isolated from various clinical specimens and ATCC strains were included...
October 31, 2018: Turkish Journal of Medical Sciences
Mohammadreza Rezaeipour
Background/aim: Weight gain is associated with balance disorders. This study intends to evaluate the postural stability in a natural stance in overweight and obese men by measuring the center of pressure (CoP) velocity in the medial-lateral (ML) and anteriorposterior (AP) directions. Materials and methods: A total number of 111 men categorized according to body mass index (BMI) into normal weight, overweight, and obese categories underwent a measurement of quiet standing with eyes open (EO) and with eyes closed (EC)...
October 31, 2018: Turkish Journal of Medical Sciences
Erman Çakal, Melia Karaköse, İlknur Öztürk Ünsal, Mustafa Şahin, Bekir Uçan, Mustafa Özbek
Background/aim: In the general population, the frequency of thyroid micronodules is increasing, and the prevalence of malignancy is higher for such nodules. Ultrasonography findings of these nodules are neither specific nor sensitive. The aim of this study was to investigate the diagnostic value of elastography in patients with thyroid micronodules. Materials and methods: A total of 224 patients with thyroid micronodules were recruited in this prospective study. All patients underwent a thyroid fine-needle aspiration biopsy...
October 31, 2018: Turkish Journal of Medical Sciences
İbrahim Doğan, Barış Eser, Sultan Özkurt, Özlem Yayar, Bülent Özgür, Hüseyin Kayadibi, Tolga Doğan, Ahmet Muşmul, Mehmet Soydan
Background/aim: Asymmetric dimethyl arginine (ADMA) is a strong predictor of cardiovascular disease and mortality in patients under hemodialysis treatment. We aimed to investigate the relationship among volume status, endothelial dysfunction, and ADMA in hemodialysis patients. Materials and methods: A total of 120 patients with a history of hemodialysis treatment were included. ADMA and CRP were measured. Echocardiographic evaluation and carotid artery intima-media thickness (CIMT) measurements were performed...
October 31, 2018: Turkish Journal of Medical Sciences
Abdullah Özer, Barış Mardin, Yiğit Kılıç, Levent Oktar, Erkan İriz, Mustafa Arslan, Yusuf Ünal, Metin Alkan
Background/aim: Recovery after coronary artery bypass graft surgery (CABG) can be complicated, leading to postoperative morbidity. The roles of hematologic and surgery-related parameters are important. The main purpose of this study is to determine the role of preoperative and postcardiopulmonary bypass neutrophil/lymphocyte ratio (NLR) on postoperative recovery. Materials and methods: Sixty-two patients aged between 41 and 80 years, scheduled for elective CABG surgery with ASA I-II risk and without a history of preoperative blood transfusion, were included in the study...
October 31, 2018: Turkish Journal of Medical Sciences
Sudipta Patra, Yasha Mukim, Muralidhar Varma, Chiranjay Mukhopadhyay, Vandana Kalwaje Eshwara
Background/aim: The current study was carried out to describe the clinical presentation, antimicrobial susceptibility pattern, and outcome of invasive nontyphoidal Salmonella disease (iNTS) in a tertiary care center. Materials and methods: A 5-year hospital-based retrospective study was carried out on blood culture-confirmed cases of iNTS. Medical records of patients were reviewed to obtain information on demography, clinical manifestations, comorbidities, complications, immune status, treatment, and clinical outcome...
October 31, 2018: Turkish Journal of Medical Sciences
Ebru Biricik, Ersel Güleç, Işıl Öcal, Mehmet Bertan Yılmaz, Feride Karacaer, Dilek Özcengiz
Background/aim: We aimed to investigate the effect of long-term use of dexamethasone and prednisolone on the reversal effect of sugammadex. Materials and methods: TTwenty-four male Wistar albino rats were divided into three groups. Dexamethasone (600 µg/kg) was given to group D, prednisolone (10 mg/kg) was given to group P, and an equivalent volume of saline per day was administered intraperitoneally to group S for 14 days, respectively. The left hemidiaphragm with attached phrenic nerve was maintained in Krebs solution...
October 31, 2018: Turkish Journal of Medical Sciences
Arzu Sağlam, Ece Esin, Mutlu Hayran, Barış Boyraz, Ayşegül Üner
Background/aim: Lymphoma cases diagnosed at one of the largest tertiary reference centers in Turkey were reviewed and findings were compared to those reported from other regions of the world. Materials and methods: Lymphomas diagnosed between 2000 and 2017 in the pathology laboratory of Hacettepe University were identified. A total of 4239 cases were analyzed. The WHO 2008 classification was used. Results: Hodgkin lymphomas accounted for almost 20% of cases. T-cell lymphomas were much more frequent (23% of our non- Hodgkin lymphoma (NHL) cases) in comparison to all other regions of the world...
October 31, 2018: Turkish Journal of Medical Sciences
Mustafa Fatih Arslan, Nuray Haliloğlu, Ayşe Erden
Background/aim: We aimed to present the magnetic resonance cholangiopancreatography (MRCP) findings of biliary tract complications after liver transplantation. Materials and methods: Seventy-five patients who underwent MRCP in our department between July 2011 and July 2015 after liver transplantation were retrospectively evaluated. The MRCP images were reevaluated by three radiologists in consensus. Diagnostic confirmation of MRCP findings was obtained with direct cholangiographic examinations or with clinical, radiological, and laboratory findings and concordance between MRCP findings and the final diagnosis was investigated...
October 31, 2018: Turkish Journal of Medical Sciences
Erdil Arsoy, Erdem Tüzün, Recai Türkoğlu
Background/aim: Benign multiple sclerosis (BMS) patients display preserved somatic neurological functions but nevertheless may develop cognitive dysfunction. Our aim was to explore the impact of computer-assisted cognitive rehabilitation (CCR) on cognitive functions of BMS patients. Materials and methods: Age- and sex-matched BMS patients (n = 21), non-BMS patients (n = 22), and healthy individuals (n = 38) were recruited for evaluation of cognitive functions. CCR was administered to 10 BMS patients and a panel of neuropsychological tests were employed at baseline and 6 months...
October 31, 2018: Turkish Journal of Medical Sciences
Feride Kural Rahatlı, Hale Turnaoğlu, Nazlı Gülsoy Kırnap, Özlem Turhan İyidir, Kemal Murat Haberal, Aresh Soudman, Nihal Uslu
Background/aim: This study was performed to assess the diagnostic accuracy of shear wave elastography by virtual touch tissue imaging quantification in patients with diffuse thyroid gland pathology and to differentiate Graves' disease from Hashimoto's thyroiditis. Materials and methods: Thirty patients with Hashimoto's thyroiditis and 22 patients with Graves' disease were evaluated with conventional ultrasonography and shear wave elastography by virtual touch tissue imaging quantification. Thirty healthy participants formed the control group...
October 31, 2018: Turkish Journal of Medical Sciences
Ramazan Dertli, Muharrem Keskin, Murat Bıyık, Hüseyin Ataseven, Hakkı Polat, Ali Demir, Pembe Oltulu, Salim Neşeloğlu, Özcan Erel, Mehmet Asıl
Background/aim: Thiol-disulfide homeostasis is an important antioxidant defense mechanism. This study was conducted to investigate dynamic thiol-disulfide homeostasis in patients with hepatitis B virus-related chronic hepatitis and liver cirrhosis. Materials and methods: Seventy-one treatment-naive patients with chronic hepatitis B (CHB), 50 patients with hepatitis B virusassociated liver cirrhosis, and 45 healthy controls were included in the study. Serum total and native thiol concentrations and serum disulfide concentrations were measured using an automated method...
October 31, 2018: Turkish Journal of Medical Sciences
Ahmet Beşir, Ersagun Tuğcugil
Background/aim: The aim of this study was to evaluate changes in intracranial pressure following tourniquet deflation using noninvasive ultrasonographic optic nerve sheath diameter (ONSD) measurements. Materials and methods: Our study included 59 adult patients between the ages of 18 and 65 years from the American Society of Anesthesiologists (ASA) I/II risk groups who were scheduled to undergo elective orthopedic surgery of the lower extremities using a tourniquet under general anesthesia. ONSD and end-tidal CO2 (ETCO2) were measured 5 times: 15 min prior to the anesthesia induction; just prior to the deflation of the tourniquet; and at 5, 10, and 15 min after the deflation...
October 31, 2018: Turkish Journal of Medical Sciences
Mustafa Kürşat Evrenos, Peyker Temiz, Fethi Sırrı Çam, Murat Yaman, Levent Yoleri, Aylin Türel Ermertcan
Background/aim: Malignant melanoma is the most common cause of death due to skin cancers. The most common mutations in RAFRAS pathway from tumor oncogenes are BRAF and NRAS. In this study, we analyzed the frequency of BRAF and NRAS gene mutations and investigated their association with clinicopathological features of melanomas in the Turkish population. Materials and methods: 65 primary cutaneous melanoma were included in the study. The mutations were evaluated with real-time PCRbased PCR-array through allele-specific amplification, and the results were correlated with various clinicopathological characteristics...
October 31, 2018: Turkish Journal of Medical Sciences
Mehmet İlker Yön, Oğuz Köktürk
Background/aim: This study aimed to evaluate whether NREM-predominant obstructive sleep apnea syndrome (OSAS) patients (NREM AHI < REM AHI) have distinct clinical and polysomnographic features compared to REM-predominant OSAS patients (REM AHI > NREM AHI). Materials and methods: A total of 342 patients (93 females and 249 males) who were admitted to the Sleep Disorders Unit at the Gazi University Faculty of Medicine and underwent polysomnography between January 2011 and April 2016 were retrospectively reviewed...
October 31, 2018: Turkish Journal of Medical Sciences
Atakan Tanaçan, Pınar Yurdakul, Fatih Aktoz, Gökçen Örgül, Meral Beksaç, Mehmet Sinan Beksaç
Background/aim: This study aimed to evaluate the effects of certain maternal, fetal, and umbilical cord blood unit factors on storage and/or discard incidence of collected cord blood units from perinatal medicine patients. Materials and methods: A total of 273 cord blood units collected between January 2011 and December 2016 in the Division of Perinatology of Hacettepe University Hospital were evaluated retrospectively in this study. Results: Of the collected cord blood units, 53.8% (147/273) were stored. Infant birth weight, cord blood unit volume, total nucleated cell count, and CD34+ cell count were statistically significantly different between the eligible and discarded cord blood unit groups (P < 0...
October 31, 2018: Turkish Journal of Medical Sciences
Şeniz Göral, İdil Yenicesu, Gülendam Bozdayı, Aysu Duyan Çamurdan, Aylin Altay Koçak
Background/aim: Parvovirus risk in blood transfusion has become a popular research topic since there are limited data on parvovirus seroprevalence in blood donors in Turkey. The aim of this study was to investigate parvovirus seroprevalence in blood donors in Turkey. Materials and methods: Blood samples of 988 blood donors admitted to a university blood bank were obtained for parvovirus B19 IgM and IgG detection. The samples were analyzed using the ELISA method. Results: IgM positivity of 3.92% and IgG positivity of 58...
October 31, 2018: Turkish Journal of Medical Sciences
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