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Turkish Journal of Medical Sciences

Yelda Varol, Ceyda Anar, Pınar Çimen, Mehmet Ünlü, Hüseyin Halilçolar, Salih Zeki Güçlü
BACKGROUND/AIM: Sex-related differences have not been thoroughly explored in chronic obstructive pulmonary disease (COPD). We aimed to evaluate possible sex-related differences in COPD Assessment Test (CAT) scores of COPD patients with or without significant anxiety and/or depression. MATERIALS AND METHODS: Stable COPD patients were prospectively enrolled in the study between July 2013 and April 2014. Levels of anxiety, depression, dyspnea, and health-related quality of life parameters were assessed using specific questionnaires, including the CAT and others...
February 27, 2017: Turkish Journal of Medical Sciences
Fatih Uzunkaya, Ahmet Özden
BACKGROUND/AIM: Fine-needle aspiration biopsy is an established method for the evaluation of thyroid nodules, but it has not been standardized worldwide yet. Adequacy of the aspirations is affected by several factors. The aim of this study is to determine the main factors affecting the adequacy and to suggest a procedural technique expected to reduce repeated procedures. MATERIALS AND METHODS: A total of 393 aspiration procedures performed using either 22-gauge or 27-gauge needles were included in the study...
February 27, 2017: Turkish Journal of Medical Sciences
Zafer Gören, Mahluga J Demirkapu, Gökçe Akpinar Acet, Sanda Çali, Medine Gülçebi Idriz Oğlu
BACKGROUND/AIM: Elderly patients are at high risk from drug-drug interactions (DDIs). This study evaluates the potential DDIs in Turkish elderly patients at a primary health care outpatient clinic. MATERIALS AND METHODS: Online database systems were used to examine DDIs on the prescriptions of patients (n = 1206). The clinical severity of DDIs was classified by the Lexi-Interact Online database. RESULTS: Of the 5059 prescriptions, 33% were found to have DDIs...
February 27, 2017: Turkish Journal of Medical Sciences
Hasan Basri Çakmak, Mücella Arikan Yorgun, Yasin Toklu, Melek Mutlu
BACKGROUND/AIM: To evaluate the effect of intravitreal pro re nata (PRN) ranibizumab treatment from the start on the best-corrected visual acuity (BCVA) and the central retinal thickness (CRT) in macular edema (ME) due to branch retinal vein occlusion (BRVO). MATERIALS AND METHODS: Patients with ME secondary to BRVO, who were treated on a PRN basis after a single intravitreal ranibizumab injection, were retrospectively evaluated. The main outcome measures were changes in BCVA and CRT as measured by optical coherence tomography...
February 27, 2017: Turkish Journal of Medical Sciences
Fereshteh Safian, Mohammad Ali Khalili, Sareh Ashourzadeh, Marjan Omidi
BACKGROUND/AIM: Polycystic ovarian syndrome (PCOS) is one of the most common causes of infertility. One of the best therapeutic options for PCOS patients is intracytoplasmic sperm injection (ICSI). In vitro maturation (IVM) can also be a useful technique for these women. The goal of this study was to evaluate both the zona pellucida (ZP) birefringence and meiotic spindle (MS) of in vivo- and in vitro-matured oocytes from PCOS patients using the PolScope system. MATERIALS AND METHODS: Immature oocytes undergoing IVM and MII oocytes were obtained from PCOS patients in an ICSI program...
February 27, 2017: Turkish Journal of Medical Sciences
Payman Zare, Amir Ali Shahbazfar, Mahsa Alem, Salman Varmaghani
BACKGROUND/AIM: The aim of the present study was to examine the anticancer effects of combination treatment with artemisinin and iron on the human gastric cancer cell line. MATERIALS AND METHODS: The AGS cell line was cultivated separately as a monolayer in culture flasks and different doses of 99% pure artemisinin with invariable doses of iron sulfate were added to the culture media and adhesive cells on the flask's bottom were stained with hematoxylin-eosin for a pathological assay...
February 27, 2017: Turkish Journal of Medical Sciences
Sinem Firtina, Özden Hatirnaz Ng, Yücel Erbilgin, Uğur Özbek, Müge Sayitoğlu
BACKGROUND/AIM: The canonical Wingless-type (WNT) pathway is involved in normal hematopoietic cell development and deregulated WNT signaling is implicated in the development of hematological malignancies. Dickkopf 1 (DKK1) acts as a modulator of the β-catenin regulated canonical pathway. Activation of DKK1 leads to apoptosis and growth suppression, whereas silencing by promoter hypermethylation results in abnormal WNT activation. The secreted inhibitor Dickkopf can antagonize WNT signaling by competitively binding to low density lipoprotein receptors (LRPs) 5 and 6...
February 27, 2017: Turkish Journal of Medical Sciences
Eylem Karatay, Özlem Gül Utku, Harun Erdal, Mehmet Arhan, İbrahim Koral Önal, Mehmet Ibiş, Özgür Ekinci, Canan Yilmaz Demirtaş, Şükrü G Dumlu
BACKGROUND/AIM: This study was designed to identify the effect of pentoxifylline on trinitrobenzene sulfonic acid (TNBS)-induced colitis in rats. MATERIALS AND METHODS: Forty-two female Wistar rats were randomly divided into 7 groups: group A, TNBS + intraperitoneal (IP) pentoxifylline; group B, TNBS + IP saline; group C, TNBS + intrarectal (IR) pentoxifylline; group D, TNBS + IR saline; group E, IP pentoxifylline + TNBS; group F, IP saline + TNBS; group G, IR saline...
February 27, 2017: Turkish Journal of Medical Sciences
Fatih Tekin, Mehmet Sürmeli, Zeynep Çizmeci, Özlem Tekin, Ergin Işik, Ömer Faruk Taner, Derun Taner Ertuğrul
BACKGROUND/AIM: The aim of this study was to reveal the tetanus immunization status of diabetic patients and to determine whether diabetic patients with foot ulcers have different TIG levels. MATERIALS AND METHODS: A cross-sectional study was designed that included diabetic patients with foot ulcers (n = 30) and diabetic patients without ulcers (n = 30). The groups were compared for serum TIG levels along with total serum protein, albumin, C-reactive protein (CRP), and total immunoglobulin G (Ig G)...
February 27, 2017: Turkish Journal of Medical Sciences
Hacer Doğanay Aydin, Doğa Vuralli, Didem Tuba Akçali, Hayrunnisa Bolay
BACKGROUND/AIM: Metoclopramide is an effective and commonly used medication in acute migraine treatment but an experimental evidence base is lacking. We aimed to investigate the antimigraine effect of metoclopramide in a migraine model and whether the analgesic effect of metoclopramide was likely to be D2 receptor-mediated. MATERIALS AND METHODS: Cortical spreading depression (CSD) was used to model migraine in adult male Wistar rats. Five CSDs were induced by pinprick...
February 27, 2017: Turkish Journal of Medical Sciences
Nilüfer Aytürk, Tülin Firat, Aysel Kükner, Candan Özoğul, Fatma Töre, İsmail Engin Kandirali, Bayram Yilmaz
BACKGROUND/AIM: To study the effect of kisspeptin, a gonadotropin release stimulator, on the testicular tissue of the rat. MATERIALS AND METHODS: Four groups were formed as follows: control, Kiss-10 501397645907nmol administration for 1 day, Kiss-10 administration for 13 days, and one last group kept for 7 days following Kiss-10 applied for 13 days. Testicular tissues were stained with hematoxylin-eosin, periodic acid Schiff, Masson trichrome staining, terminal deoxynucleotidyl transferased UTP nick-end labeling, and Ki-67 immune staining...
February 27, 2017: Turkish Journal of Medical Sciences
Mohaddese Mahboubi, Tahereh Falsafi, Majid Sadeghizadeh, Fatemeh Mahjoub
BACKGROUND/AIM: Outer inflammatory protein A (OipA) is an important adhesin of Helicobacter pylori. Our goal was to assess the role of OipA in protection of C57BL/6 mice against H. pylori. MATERIALS AND METHODS: C57BL/6 mice were mucosally immunized with recombinant OipA protein, OipA + propolis, propolis, and phosphate-buffered saline. After vaccination, anti-OipA IgA was measured. Mice were challenged three times with 5 × 10(7) CFU of the H. pylori B19 strain...
February 27, 2017: Turkish Journal of Medical Sciences
Zerrin Defne Dündar, Mehmet Ergin, İbrahim Kilinç, Tamer Çolak, Pembe Oltulu, Başar Cander
BACKGROUND/AIM: This study aimed to evaluate oxidative stress markers of liver tissue in a mouse α-amanitin poisoning model with three different toxin levels. MATERIALS AND METHODS: The mice were randomly divided into Group 1 (control), Group 2 (0.2 mg/kg), Group 3 (0.6 mg/kg), and Group 4 (1.0 mg/kg). The toxin was injected intraperitoneally and 48 h of follow-up was performed before sacrifice. RESULTS: Median superoxide dismutase activities of liver tissue in Groups 3 and 4 were significantly higher than in Group 1 (for both, P = 0...
February 27, 2017: Turkish Journal of Medical Sciences
Mahmut Yüksel, Sabite Kacar, Muhammet Yener Akpinar, Fatih Saygili, Meral Akdoğan Kayhan, Selçuk Dişibeyaz, Yasemin Özin, Mustafa Kaplan, İhsan Ateş, Ertuğrul Kayaçetin
BACKGROUND/AIM: We aimed to present the endoscopic ultrasound (EUS) features of gastric lesions suggesting gastric ectopic pancreas during upper gastrointestinal endoscopy that were diagnosed in our gastroenterology unit, which is a tertiary center for endoscopic procedures in Turkey. MATERIALS AND METHODS: The data of patients who underwent upper gastrointestinal EUS in our center between April 2012 and July 2014 were retrospectively analyzed. RESULTS: All of the lesions suggesting gastric ectopic pancreas were localized in the gastric antrum...
February 27, 2017: Turkish Journal of Medical Sciences
İlknur Aytekin, Maruf Şanli, Ahmet Ferudun Işik, Bülent Tunçözgür, Ahmet Uluşan, Kemal Bakir, Seval Kul, Levent Elbeyli
BACKGROUND/AIM: For the early stage of nonsmall-cell lung cancer, surgical resection provides the best survival, but the surgical risk generally increases with age because of the increased prevalence of comorbidities, especially cardiovascular disorders. The aim of this study was to compare survival and mortality rates of two groups with different ages, younger and older than 70 years, who went curative resection for nonsmall-cell lung cancer. MATERIALS AND METHODS: We analyzed the patients who underwent curative lung cancer surgery in the Department of Thoracic Surgery of Gaziantep University Research Hospital between January 1997 and November 2014...
February 27, 2017: Turkish Journal of Medical Sciences
Salim Erkaya, Murat Öz, Hasan Onur Topçu, Ali Levent Şirvan, Tayfun Güngör, Mehmet Mutlu Meydanli
BACKGROUND/AIM: The purpose of this study is to investigate the prognostic significance of lower uterine segment (LUS) involvement in endometrial cancer (EC). MATERIALS AND METHODS: We reviewed the patients who were operated at our institution between July 2007 and March 2015 with the diagnosis of EC. Tumors localized in the corpus and involving the LUS or localized entirely in the LUS formed Group A, while tumors in the uterine corpus without LUS involvement formed Group B...
February 27, 2017: Turkish Journal of Medical Sciences
Fusun Bozkirli, Nurdan Bedirli, Mehmet Akçabay
BACKGROUND/AIM: The aim of this study was to quantify the changes in middle ear pressure (MEP) during robot-assisted radical prostatectomy (RARP). MATERIALS AND METHODS: Thirty patients undergoing RARP were included in this study. MEP was obtained at the following time points: awake (T1), postintubation (T2), pneumoperitoneum + 1 h of Trendelenburg position (T3), pneumoperitoneum + 2 h of Trendelenburg position (T4), pneumoperitoneum + 3 h of Trendelenburg position (T5), desufflation + supine position (T6), and 1 h after extubation in the postanesthesia care unit (T7)...
February 27, 2017: Turkish Journal of Medical Sciences
Syed Rizwan Hussain, Sabir Ali, Ajai Singh, Vineet Kumar, Nazia Rizivi, Manish Yadav, Mohammad Kaleem Ahmad, Vijay Kumar, Abbas Ali Mahdi
BACKGROUND/AIM: Osteosarcoma requires an angiogenesis process. CYR61 is one of the extracellular signaling molecules that promote angiogenesis, tumor growth, and the malignancy of osteosarcoma. In the present study, we investigate the CYR61 gene variations in osteosarcoma and their correlations with clinicopathological findings. MATERIALS AND METHODS: We performed variation analysis of the CYR61 gene in 58 patients with osteosarcoma. With an aim to ascertain the variety of variations in exons 2, 3, 4, and 5 of the CYR61 gene in osteosarcoma, we did a PCR-SSCP followed by DNA sequencing...
February 27, 2017: Turkish Journal of Medical Sciences
Tülay Kamaşak, Süleyman Türedi, Hepsen Mine Serin, Ahmet Menteşe, Abdülkadir Gündüz, Ahmet Alver, Ali Cansu
BACKGROUND/AIM: In recent years ischemia-modified albumin (IMA) has been suggested as a marker that can be used in differentiating nonconvulsive conditions from epilepsy. The purpose of this study was to investigate changes in IMA levels caused by generalized clonic tonic (GTC) seizures. MATERIALS AND METHODS: A total of 114 children presenting to the Karadeniz Technical Pediatric Emergency Polyclinic with GTC seizures were included in the study. Sixteen cases meeting the inclusion criteria were included in the study and sixteen healthy children were enrolled as the control group...
February 27, 2017: Turkish Journal of Medical Sciences
Oğuz Reşat Sipahi, Arzu Nazli Zeka, Meltem Taşbakan, Hüsnü Pullukçu, Bilgin Arda, Tansu Yamazhan, Hilal Sipahi, Sercan Ulusoy
BACKGROUND/AIM: Healthcare-associated meningitis (HCAM) is a relatively rare entity with significant morbidity and mortality. The aim of this study was to systematically review the Turkish medical literature for acute nosocomial meningitis. MATERIALS AND METHODS: One national (ULAKBİM) and two international ( and databases were searched. In addition, abstracts of four national congresses held between 2004 and 2013 were searched for reports for HCAM meningitis...
February 27, 2017: Turkish Journal of Medical Sciences
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