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Turkish Journal of Medical Sciences

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https://www.readbyqxmd.com/read/29307170/islet-transplantation-promotes-podocyte-regeneration-in-a-model-of-diabetic-nephropathy
#1
Ziqiang Xu, Jie Fan
Background/aim: The purpose of this study was to observe whether islet transplantation could induce glomerular parietal epithelial cells to express podocyte proteins in a rat model of streptozotocin-induced diabetic nephropathy (DN).Materials and methods: A total of 18 rats were given single injections of streptozotocin to induce a DN model. Eight weeks after the modeling, successfully established DN rats were divided into three groups: an untreated group (DN group), an islet-transplanted group (IT group), and an insulin group (IN group)...
December 19, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/29306261/empirical-therapy-and-teicoplanin-use-in-periprosthetic-joint-infections
#2
LETTER
Zeliha Koçak Tufan, Hatice Rahmet Güner, Gülruhsar Yılmaz, Aybegüm Özşahin, Murat Bozkurt, Mehmet Akın Taşyaran
HASH(0x4f3c040)
December 19, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/29306260/interleukin-6-and-hepcidin-expression-changes-in-cardiac-tissue-of-long-term-trained-and-untrained-rats-after-exhaustive-exercise
#3
Badegül Sarıkaya, Ali Doğan Dursun, Elçin Yağmur Taylan Deveden, Lamia Pınar
Background/aim: Exercise benefits the cardiovascular system, but strenuous exercise can cause cardiac damage and induce cytokine production, particularly that of interleukin-6 (IL-6). Hepcidin, which is primarily regulated by IL-6, increases after exercise. Hepcidin is a possible protective factor against the adverse effects of strenuous exercise such as oxidative stress. The aim of the study is to reveal that training increases hepcidin and attenuates increased levels of IL-6 in the hearts of exhaustively exercised rats by comparing the IL-6 and hepcidin mRNA expression levels in trained and untrained groups...
December 19, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/29306259/effects-of-n-acetylcysteine-on-ovarian-tissue-autografted-intogranulation-tissue-compared-to-back-muscle-in-rats
#4
Farideh Danehpoya, Mojtaba Karimipour, Masoumeh Zirak Javanmard, Bagher Pourheydar
Background/aim: Ovarian transplantation can preserve fertility in cancer patients. The aim of this study was to compare ovarian transplantation into granulation tissue (GT) versus back muscle (BM) sites and also to investigate the effects of N-acetylcysteine (NAC) as an antioxidant on ovarian survival in a rat autograft model.Materials and methods: Twenty-eight adult female rats were divided into four equal groups (n = 7 each) as follows: Group 1, ovarian tissue grafted into GT + saline (GT + saline); Group 2, ovarian tissue grafted into GT + NAC (GT + NAC); Group 3, ovarian tissue grafted into BM + saline (BM + saline); and Group 4, ovarian tissue grafted into BM + NAC (BM + NAC)...
December 19, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/29306258/the-reno-protective-effects-of-atorvastatin-in-crush-syndrome-and-rhabdomyolysis-is-there-a-dilemma
#5
Demet Acar, Mustafa Gülpembe, Can Gökay Yıldız, Emine Nur Özdamar, Kerem Açıkgöz, Ahmet Çağlar, Başar Cander
Background/aim: We aim to determine the effects of low-dose atorvastatin treatment together with crush fluid resuscitation on renal functions and muscle enzyme levels in a rat model of crush syndrome. Materials and methods: The study involved female Wistar Albino rats weighing 250-300 g that were housed with free access to food and water. The crush model was obtained by compression. Rats were randomly divided into four groups: control (C) group, atorvastatin + crush fluid (ACF) group, crush fluid (CF) group, and hypertonic saline (%3) + mannitol + sodium bicarbonate (SM) group...
December 19, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/29306257/histopathological-effects-of-mesenchymal-stem-cells-in-rats-with-bladder-and-posterior-urethral-injuries
#6
Berat Dilek Demirel, Ünal Bıçakcı, Rıza Rızalar, Ferda Alpaslan Pınarlı, Oğuz Aydın
Background/aim: To evaluate the effects of mesenchymal stem cell (MSC) therapy in an experimental bladder and posterior urethral injury model. Materials and methods: The study subjects consisted of 40 male Wistar albino rats that were divided into four groups: control group (n = 10) (the bladder was only surgically opened and closed), sham group (n = 10) (surgical procedure), IVMSC group (n= 10) (surgical procedure and intravenous MSC treatment), and LMSC group (n = 10) (surgical procedure and local MSC treatment)...
December 19, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/29306256/isolation-and-culture-of-adult-mouse-vestibular-nucleus-neurons
#7
Aydın Him, Serap Altuntaş, Gürkan Öztürk, Ender Erdoğan, Nureddin Cengiz
Background/aim: Isolated cell cultures are widely used to study neuronal properties due to their advantages. Although embryonic animals are preferred for culturing, their morphological or electrophysiological properties may not reflect adult neurons, which may be important in neurodegenerative diseases. This paper aims to develop a method for preparing isolated cell cultures of medial vestibular nucleus (MVN) from adult mice and describe its morphological and electrophysiological properties.Materials and methods: Vestibular nucleus neurons were mechanically and enzymatically isolated and cultured using a defined medium with known growth factors...
December 19, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/29306255/adaptation-reliability-and-validity-study-of-the-hwalek-sengstockelder-abuse-screening-test-h-s-east-a-turkish-version
#8
Nilgün Özçakar, Akça Toprak Ergönen, Mehtap Kartal, Hakan Baydur
Background/aim: The most important issues in elder abuse and neglect are lack of awareness and difficulties in determining the situation. Our aim is to determine the reliability and validity of the Turkish version of the Hwalek-Sengstock Elder Abuse Screening Test (H-S/EAST).Materials and methods: The H-S/EAST (15-itemed, three-dimensional: direct abuse, characteristics of vulnerability, and potentially abusive situation) was translated according to the guidelines and experts evaluated it for content validity and cultural adaptation...
December 19, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/29306254/three-dimensional-evaluation-of-pelvic-posture-in-adolescents-with-and-without-a-history-of-low-back-pain
#9
Seher Özyürek, Arzu Genç, Hayriye Kul Karaali, Zeliha Candan Algun
Background/aim: This study aimed to evaluate the three-dimensional (3D) profile of pelvic posture and postural displacements of the pelvis in adolescents with and without a history of low back pain (LBP). Materials and methods: Thirty-two adolescents participated in this study. Participants were asked if they had ever suffered LBP at some point in their lives. Participants were divided into two groups: with a history of LBP (LBP group) and without a history of LBP (control group). For 3D evaluation of pelvic posture, the PosturePrint system was used...
December 19, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/29306253/molecular-analysis-and-prevalence-of-huntington-disease-in-northwestern-iran
#10
Mahmoud Shekari Khaniani, Parisa Aob, Mohammadreza Ranjouri, Sima Mansoori Derakhsan
Background/aim: Huntington disease (HD) is a progressive adult-onset neurodegenerative disorder presenting an autosomal dominant inheritance. Since there is no information on the prevalence of HD in northwestern Iran, the aim of the present study was to determine the prevalence of HD and the number of CAG trinucleotide repeats in the population of northwestern Iran.Materials and methods: Genomic DNA was extracted from whole blood by the salting-out method. DNA samples were analyzed to determine the number of CAG trinucleotide repeats of the HD gene...
December 19, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/29306252/the-diagnostic-accuracy-of-endobronchial-ultrasound-guided-transbronchial-needle-aspiration-ebus-tbna-in-mediastinal-tuberculous-lymphadenitis
#11
Onur Fevzi Erer, Serhat Erol, Ceyda Anar, Can Biçmen, Zekiye Aydoğdu, Serir Aktoğu
Background/aim: Mediastinal lymph nodes are the second most commonly affected lymph nodes in tuberculous lymphadenitis. It is often difficult to diagnose tuberculosis in patients with lymphadenopathy without parenchymal lesions. The aim of this study was to describe the diagnostic utility of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) in patients with isolated mediastinal tuberculous lymphadenitis (MTLA). Materials and methods: This study included 527 patients who had undergone EBUS-TBNA between December 2012 and December 2014...
December 19, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/29306251/evaluation-of-renal-anomalies-inferior-vena-cava-variations-and-left-renalvein-variations-by-lumbar-magnetic-resonance-imaging-in-3000-patients
#12
Alper Dilli, Fatma Sevin Coşar Ayaz, Keziban Karacan, Kürşad Zengin, Ümit Yaşar Ayaz, Osman Raif Karabacak, Baki Hekimoğlu
Background/aim: The variations and anomalies of the kidneys besides the variations of the inferior vena cava (IVC) and left renal vein (LRV) are mostly asymptomatic, but they carry potential risks particularly during retroperitoneal surgery and radiological interventions. Our aim was to find the frequencies, types, and sex distribution of renal anomalies and variations of the IVC and LRV utilizing magnetic resonance imaging (MRI). Materials and methods: Between November 2010 and April 2011, a retrospective study was conducted including lumbar spinal MRI of 3000 consecutive patients (1869 females and 1131 males) with a median age of 54 years (range: 9-78 years)...
December 19, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/29306250/topographic-methods-to-expose-the-exiting-points-of-supratrochlear-supraorbital-and-zygomaticotemporal-nerves
#13
Mesut Sabri Tezer, İsmail Yağmurhan Gilan, Özlem Elvan, Vedia Bennu Özcömert, Mustafa Aktekin
Background/aim: We evaluated the relations of the exiting points of supratrochlear (STN), supraorbital (SON), and zygomaticotemporal (ZTN) nerves with certain landmarks to provide improved anatomic knowledge. Materials and methods: The twenty-eight hemifaces of 5 fresh frozen and 11 embalmed heads (5 female and 11 male cadavers) were dissected. Distance and angular measurements were made between the exiting points of the nerves to the midline, lateral, and medial canthi. Comparisons of side, sex, and cadaver groups were evaluated...
December 19, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/29306249/biomarker-and-shear-stress-in-secondary-pediatric-pulmonary-hypertension
#14
Ayhan Pektaş, Rana Olguntürk, Serdar Kula, Erman Çilsal, Ayşe Deniz Oğuz, Fatma Sedef Tunaoğlu
Background/aim: Endothelial dysfunction, tissue damage, inflammation, and microthrombosis are involved in the pathogenesis of pulmonary hypertension (PH), which may be present as a complication of congenital heart diseases. This study aims to identify how indicators of endothelial dysfunction (shear stress), tissue damage (brain natriuretic peptide and troponin T), inflammation (C-reactive protein (CRP)), and microthrombosis (D-dimer and von Willebrand factor) are altered in children with congenital left-to-right shunting...
December 19, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/29306248/cyclooxygenase-2-cox-2-gene-polymorphism-in-patients-with-differentiated-thyroid-carcinomas-in-the-turkish-population
#15
Bekir Uçan, Mustafa Özbek, Mustafa Şahin, Muhammed Kızılgül, Erman Çakal
Background/aim: The most common thyroid malignancies are papillary and follicular thyroid carcinomas. They account for approximately 85%-90% of all thyroid cancers. Recent studies have reported the relevance of cyclooxygenase-2 (COX-2) gene polymorphism in human carcinogenesis. The aim of this study was to investigate the relationship between thyroid carcinoma and COX-2 gene polymorphism in the Turkish population.Materials and methods: We included a total of 96 differentiated thyroid cancer patients (mean age: 46...
December 19, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/29306247/association-between-deep-neck-space-abscesses-and-internal-carotid-artery-narrowing-in-pediatric-patients
#16
Betül Emine Derinkuyu, Öznur Boyunağa, Meltem Polat, Çağrı Damar, Anıl Tapısız Aktaş, Ayşe Gül Alımlı, Çiğdem Öztunalı, Soner Sertan Kara, Murat Uçar, Hasan Tezer
Background/aim: Our aim was to interpret the effects of deep neck space abscesses on the adjacent carotid artery according to abscess location, as well as to determine narrowing by calculating the mean stenosis ratios.Materials and methods: Neck computed tomography scans and clinical data of 45 children with neck abscesses were evaluated retrospectively for abscess location and internal carotid artery narrowing. The lumen areas of the carotid arteries were measured from standard levels, and stenosis ratios were calculated with two different techniques...
December 19, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/29306246/hyperbolic-relation-between-beta-cell-function-and-insulin-sensitivity-for-type-2-diabetes-mellitus-malaria-influenza-helicobacter-pylori-chlamydia-pneumoniae-and-hepatitis-c-virus-infection-induced-inflammation-oxidative-stress-and-temporary-insulin-resistance
#17
Jean Bosco Kasiam Lasi On'kin, Benjamin Longo-Mbenza, Venant Tchokonte-Nana, Augustin Nge Okwe, Nelly Kangola Kabangu
Background/aim: We calculated the homeostatic model assessment (HOMA) for estimating insulin sensitivity and beta-cell function in normal, healthy nondiabetics with infections (malaria, influenza, HIV, Helicobacter pylori, Chlamydia pneumoniae, and hepatitis C virus), type 2 diabetic black patients, and healthy controls from Kinshasa, DR Congo. Materials and methods: A case-control study was carried out between 2006 and 2007 for black Central African participants managed for HOMA.Results: In total, 219 patients and 110 healthy controls were matched for sex and age...
December 19, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/29306245/turkish-version-of-the-motor-function-measure-scale-mfm-32-forneuromuscular-diseases-a-cross-cultural-adaptation-reliability-and-validity-study
#18
Habibe Serap İnal, Ela Tarakçı, Devrim Tarakçı, Gülcan Aksoy, Sezan Mergen Kılıç, Hakan Beşer, Çiğdem Beşer, Arzu Razak Özdinçler, Hacer Durmuş Tekçe, Fatma Yeşim Parman, Feza Deymeer, Zehra Piraye Oflazer
Background/aim: The Motor Function Measure (MFM-32) is a classification system for ambulant and nonambulant patients with neuromuscular diseases (NMDs). We aimed to translate it into Turkish, culturally adapt it, and test its reliability and validity for Turkish patients with NMDs.Materials and methods: The translation of the 32 items assessing three functional areas: standing position and transfers (D1: 13), axial/proximal (D2: 12), and distal (D3: 7) motor functions was performed according to the established guidelines for cross-cultural adaptation...
December 19, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/29306244/tnf-alpha-863c-a-promoter-and-tnfrii-196t-g-exonic-variationsmay-be-risk-factors-for-juvenile-idiopathic-arthritis
#19
Bahadır Batar, Sezen Özman, Kenan Barut, Özgür Kasapçopur, Mehmet Güven
Background/aim: Juvenile idiopathic arthritis (JIA) is a chronic complex autoimmune disease. Genetic and environmental factors increase the risk of JIA. It is accepted that alterations in immune system pathways play an important role in the pathogenesis of JIA. The aim of the study was to investigate the possible association between immune system regulatory gene polymorphisms and JIA in Turkish patients. Materials and methods: We analyzed eight polymorphisms, TNF-alpha-863 C > A, TNFRII 196 T > G, IL2-631 G > A, IL13-1112 C > T, CCR2 190 G > A, CCR5delta32, CTLA4-1661 A > G, and PTPN22 1858 C > T, in 76 patients with JIA and in 80 healthy controls, who were of a similar age and same sex...
December 19, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/29306243/tnf-%C3%AE-and-tgf-%C3%A3-level-after-intraoperative-allogeneic-red-blood-cell-transfusion-in-orthopedic-operation-patients
#20
Hamed Hassani, Alireza Khoshdel, Seyed Reza Sharifzadeh, Mohamad Foad Heydari, Shaban Alizadeh, Ali Noroozi Aghideh
Background/aim: Blood transfusion is associated with immunosuppression, referred to as transfusion-related immunomodulation (TRIM). In this study, for the first time, changes in the concentration of TGF-ß and TNF-α were measured postoperatively in orthopedic patients with intraoperational allogeneic red blood cell transfusion. Considering the use of packed cell units with different ages, it is possible to suggest the more appropriate product for clinical applications.Materials and methods: Two groups of 35 orthopedic surgery patients (with or without transfusion as case and control groups, respectively) were involved...
December 19, 2017: Turkish Journal of Medical Sciences
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