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Turkish Journal of Medical Sciences

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https://www.readbyqxmd.com/read/30121057/ginger-zingiber-officinale-prevents-severe-damage-to-the-lungs-due-to-hyperoxia-and-inflammation
#1
Atilla Çifci, Cüneyt Tayman, Halil İbrahim Yakut, Halit Halil, Esra Çakır, Ufuk Çakır, Salih Aydemir
Background/aim: Hyperoxia- and inflammation-induced lung injury is an important cause of the development of bronchopulmonary dysplasia (BPD) in premature infants. We aimed to ascertain the beneficial effects of ginger ( Zingiber officinale ) on rat pups exposed to hyperoxia and inflammation. Materials and methods: Thirty-six newborn Wistar rats were randomly divided into 3 groups as the hyperoxia (95% O 2 ) + lipopolysaccharide (LPS) group, the hyperoxia + LPS + ginger-treated group, and the control/no treatment group (21% O 2 )...
August 16, 2018: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/30121056/octreotide-ameliorates-dermal-fibrosis-in-bleomycin-induced-scleroderma
#2
Sibel Oyucu Orhan, Ahmet Tektemur, Nevzat Gözel, İbrahim Hanifi Özercan, Servet Yolbaş, Ahmet Yıldırım, Ebru Önalan, Süleyman Serdar Koca
Background/aim: Insulin-like growth factor (IGF)-I is a differentiation and growth factor. Antifibrotic action of octreotide has been reported in pulmonary fibrosis. The present study aimed to research the prophylactic and therapeutic potential of octreotide on a bleomycin (BLM)-induced experimental scleroderma model. Materials and methods: Sixty Balb/c female mice were divided into 6 groups. Daily subcutaneous BLM (100 μg) was injected for 3 weeks in groups II and III and for 6 weeks in groups V and VI...
August 16, 2018: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/30121055/repaglinide-inhibits-cyclosporine-a-induced-renal-tubular-toxicity-by-affecting-apoptosis-and-bax-and-bcl-2-expression
#3
Jin Li, Hui Li, Qixiong Li, Ying Xue
Background/aim: Repaglinide (RG) is a prandial glucose regulator used for the treatment of type 2 diabetes. Our recent study showed that RG plays an important role in cyclosporine A (CsA)-induced nephrotoxicity through its antioxidant properties. However, it is not known whether or not RG has any protective effect on CsA-induced renal tubular toxicity by affecting apoptosis and expression of apoptosis-associated protein. The purpose of this study was to investigate the effects of RG on CsA-induced renal tubule apoptosis and Bax and Bcl-2 protein expression in rats...
August 16, 2018: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/30119595/the-in-vitro-effect-of-antimicrobial-photodynamic-therapy-on-candida-and-staphylococcus-biofilms
#4
Özlem Güzel Tunçcan, Ayşe Kalkancı, Elif Ayca Unal, Olkar Abdulmajed, Merve Erdoğan, Murat Dizbay, Kayhan Çağlar
Background/aim: This study was designed to evaluate the effect of antimicrobial photodynamic treatment (APDT) in a biofilm model using combinations of various dyes (rose bengal, riboflavin, and methylene blue) as photosensitizers and light sources (LED and UVA) against staphylococcal and candidal biofilms. Materials and methods: Sterile microtiter plates were used for the development and quantification of the biofilms. APDT was carried out using combinations of the light sources and dyes...
August 16, 2018: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/30119594/reference-values-of-anthropometric-measurements-in-healthy-late-preterm-and-term-infants
#5
Betül Siyah Bilgin, Özgün Uygur, Demet Terek, Özge Altun Köroğlu, Mehmet Yalaz, Mete Akısü, Özgür Çoğulu, Nilgün Kültürsay
Background/aim: Geographical distribution, ethnicity, and other socioeconomic factors may affect anthropometric measurements, and for that reason each society should determine their own measurements accounting for those factors. In this study, we aimed to determine the anthropometric measurements of healthy late preterm and term infants to compare the results with other national and international studies. Materials and methods: This sectional study was carried out among 1197 infants born with a gestational age of ≥35 weeks...
August 16, 2018: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/30119164/methodology-of-a-new-inflammatory-arthritis-registry-treasure
#6
Umut Kalyoncu, Etem Koray Taşcılar, Ali İhsan Ertenli, Hüseyin Ediz Dalkılıç, Cemal Bes, Orhan Küçükşahin, Timuçin Kaşifoğlu, Nilüfer Alpay Kanıtez, Hakan Emmungil, Gezmis Kimyon, Nazife Şule Yaşar Bilge, Servet Akar, Mehmet Pamir Atagündüz, Süleyman Serdar Koca, Aşkın Ateş, Veli Yazısız, Ender Terzioğlu, Emine Duygu Ersözlü, Müge Aydın Tufan, Muhammet Çınar, Rıdvan Mercan, Ali Şahin, Şükran Erten, Yavuz Pehlivan, Sedat Yılmaz, Ayşe Bahar Keleşoğlu Dinçer, Önay Gerçik, Belkıs Nihan Coşkun, Burcu Yağız, Sema Kaymaz Tahra, Aysun Aksoy, Ömer Karadağ, Levent Kılıç, Sedat Kiraz
Background/aim: The TReasure registry, created in 2017, is an observational multicenter cohort that includes inflammatory arthritis patients. This article reviews the methodology and objectives of the TReasure registry established to collect data from rheumatoid arthritis (RA) and spondyloarthritis (SpA) patients. Methodology: Fifteen rheumatology centers in Turkey will contribute data to the TReasure database. The actual proprietor of the database is the Hacettepe Rheumatology Association (HRD) and Hacettepe Financial Enterprises...
August 16, 2018: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/30119163/ketamine-dosing-for-sedation-during-repeated-radiotherapy-sessions-in-children
#7
Oya Yalçın Çok, Hatice Evren Eker, Aniş Arıboğan
Background/aim: We report the analysis of ketamine doses needed and the recovery times in pediatric oncology patients undergoing repeated radiotherapy sessions. Materials and methods: In a single-blind prospective study design, thirty-three pediatric patients undergoing radiotherapy due to oncologic disorders received 2 mg/kg ketamine and 10 μg/kg atropine intravenously and the rescue drug to be administered was ketamine at 0.5 mg/kg when the sedation level was inadequate...
August 16, 2018: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/30119162/peripheral-arterial-disease-increases-the-risk-of-multidrug-resistant-bacteria-and-amputation-in-diabetic-foot-infections
#8
Pınar Aysert Yıldız, Tuğba Özdil, Murat Dizbay, Özlem Güzel Tunçcan, Kenan Hızel
Background/aim: The aim of this study was to investigate the microbiological profile and resistance rates of diabetic foot infections (DFIs) and to determine the effect of peripheral arterial disease (PAD) on the microbiology, clinical condition, and treatment outcomes. Materials and methods: Characteristics, laboratory and imaging data, and the treatment modalities of patients admitted to our hospital with a diagnosis of DFI (PEDIS classification 3–4) during 2005–2016 were analyzed according to the presence of PAD...
August 16, 2018: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/30119161/hand-functions-in-systemic-lupus-erythematosus-a-comparative-study-with-rheumatoid-arthritis-patients-and-healthy-subjects
#9
Songül Bağlan Yentür, Zeynep Tuna, Oğuzhan Mete, Ahmet Gökkurt, Nurten Gizem Tore, Hamit Küçük, Berna Göker, Deran Oskay
Background/aim: Systemic lupus erythematosus (SLE) frequently affects the small joints of the hand and may result in difficulty in activities of daily living. There are very few studies evaluating the problems encountered in the hands in patients with SLE. The aim of this study is to evaluate hand functions in patients with SLE and compare them with rheumatoid arthritis (RA) patients and healthy subjects. Materials and methods: A total 46 female patients meeting the SLE classification criteria were recruited...
August 16, 2018: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/30119160/effect-of-intravitreal-bevacizumab-on-macular-thickness-exploring-serum-and-vitreous-proangiogenic-biomarkers-in-patients-with-diabetic-macular-edema
#10
Tayyaba Gul Malik, Syed Shoaib Ahmed, Roquyya Gul, Muhammad Khalil, Abrar Ahmed Malik, Masoom Khan
Background/aim: This study evaluates diabetic macular-edema (DME) patients for the effect of intravitreal bevacizumab (IVB) injection on macular thickness and proangiogenic biomarkers in serum and vitreous. Materials and methods: Forty DME patients were analyzed for macular thickness (MT). Twelve proangiogenic biomarkers in serum and vitreous were analyzed before and after IVB. Results: Significant decrease in MT with vitreal vascular endothelial growth factor-A (VEGF-A) was observed as expected after IVB, while serum VEGF-A did not follow a decreasing trend in contrast to VEGF-C, which decreased both in serum and vitreous...
August 16, 2018: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/30119159/rising-stars-of-dpld-survival-fvc-and-exercise-desaturation-a-single-center-study
#11
Ayperi Öztürk, Oya Kayacan
Background/aim: Diffuse parenchymal lung diseases (DPLDs) comprise a broad, heterogeneous group of diseases with common functional characteristics and a common final pathway, usually leading to irreversible fibrosis. We investigated the effects of the physiological and functional parameters and of pulmonary hypertension (PH) on survival in DPLDs. Materials and methods: The study included 158 patients with DPLDs. Patient data were examined retrospectively, and survival status was obtained through phone calls...
August 16, 2018: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/30119158/detection-of-the-differences-in-the-apparent-diffusion-coefficient-values-in-different-histopathological-types-of-malignant-breast-lesions-and-comparison-of-cellular-region-stroma-ratio-and-histopathological-results
#12
Nevin Köremezli Keskin, Pınar Balcı, Işıl Başara Akın, Esra Yavuz Gürkan, Ali İbrahim Sevinç, Merih Güray Durak, Ayça Erşen Danyeli
Background/aim: This study aimed to compare the apparent diffusion coefficient (ADC) values of malignant breast lesions with different histopathological types on diffusion-weighted imaging (DWI) and the cellular region/stroma (CR/S) ratio and histopathological results. Materials and methods: Breast diffusion-weighted magnetic resonance findings of 59 patients were retrospectively analyzed for malignant breast lesions. The CR/S ratio was calculated using breast wide-excisional biopsy or mastectomy specimens...
August 16, 2018: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/30119157/the-validity-and-reliability-of-the-turkish-version-of-the-leicester-cough-questionnaire-in-copd-patients
#13
Fikret Kurhan, Tuğba Göktalay, Yavuz Havlucu, Seçil Sarı, Arzu Yorgancıoğlu, Pınar Çelik, Ayşın Şakar Coşkun
Background/aim: The reliability and validity of the Turkish version of the Leicester Cough Questionnaire (LCQ) have been evaluated before. This study aimed to validate the Turkish version of the LCQ in chronic obstructive pulmonary disease (COPD) patients with cough. Materials and methods: COPD (GOLD B, C, D) patients over age 40 (n = 75) and healthy volunteers as a control group (n = 75) were included. A sociodemographic data form, the LCQ, the Short Form-36 (SF-36) quality of life questionnaire, and the World Health Organization Quality of Life Brief Form for Turkish people were completed...
August 16, 2018: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/30119156/reliability-and-validity-of-the-turkish-version-of-pain-assessment-checklist-for-seniors-with-limited-ability-to-communicate-pacslac-t
#14
Öznur Büyükturan, Buket Büyükturan, Aysu Yetiş, Mehmet İlkin Naharcı, Nuray Kırdı
Background/aim: This study aimed to assess validity and reliability of the Turkish version of Pain Assessment Checklist for Seniors with Limited Ability to Communicate (PACSLAC-T). Materials and methods: The individuals who met inclusion criteria of the study were in patients of a hospital and a long-term care facility. Mini Mental Status Exam (MMSE), Cornell Dementia Depression Scale (CDDS), Global Deterioration Scale (GDS), visual analogue scale (VAS), and PACSLAC-T were administered to all subjects...
August 16, 2018: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/30119155/the-impact-of-donor-and-recipient-kir-genes-and-kir-ligands-on-the-occurrence-of-acute-graft-versus-host-disease-and-graft-survival-after-hla-identical-sibling-hematopoietic-stem-cell-transplantation
#15
Seyed Ahmad Hoseinian, Davood Jafari, Mehdi Mahmoodi, Kamran Alimoghaddam, Mohammadreza Ostadali, Azita Talebzadeh Bonakdar, Arron Munggela Foma, Mir Saeed Yekaninejad, Ali Akbar Amirzargar
Background/aim: After allogeneic hematopoietic stem cell transplantation (allo-HSCT), donor natural killer (NK) cells trigger alloreactions against potential recipient cells by their killer immunoglobulin-like receptors (KIRs). This study investigated whether KIR/HLA genotypes and KIR haplotypes of donors and recipients exhibit a critical function in the prevalence of acute graft-versus-host disease (aGVHD) and persistence of the graft after HLA-identical sibling allo-HSCT for patients with hematological malignancies...
August 16, 2018: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/30119154/what-has-changed-in-the-utility-of-pediatric-eeg-over-the-last-decade
#16
Leman Tekin Orgun, Ebru Arhan, Kürşad Aydın, Tunzale Rzayeva, Tuğba Hırfanoğlu, Ayşe Serdaroğlu
Background/aim: We evaluated the utility of electroencephalography (EEG) in children with neurological conditions and compared the results with those of our previous study on excessive uses of pediatric EEG, which was published in 2003. We also evaluated the possibility of subsequent EEGs and satisfactory duration of EEG recordings according to EEG type and admission status. We also evaluated the yield of varying durations of EEG recordings. Materials and methods: All consecutive pediatric EEG records performed at Gazi University EEG laboratory during a 1-year period were retrospectively reviewed...
August 16, 2018: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/30119153/efficacy-and-safety-of-lenalidomide-and-dexamethasone-in-patients-with-relapsed-refractory-multiple-myeloma-a-real-life-experience
#17
Nur Soyer, Püsem Patır, Ayşe Uysal, Mustafa Duran, Hatice Demet Ünal, Raika Durusoy, Murat Tombuloğlu, Fahri Şahin, Mahmut Töbü, Filiz Vural, Güray Saydam
Background/aim: In Turkey, lenalidomide plus dexamethasone (RD) has been used to treat relapsed/refractory multiple myeloma (RRMM) since 2010. This retrospective, single-center study evaluated the efficacy and tolerability of RD in patients with RRMM between October 2010 and June 2016. Materials and methods: Patients’ records were reviewed, and overall (OS) and progression-free survival (PFS) were assessed. Results: One hundred and twenty patients (71 males; 59...
August 16, 2018: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/30119152/effects-of-volume-controlled-equal-ratio-ventilation-with-recruitment-maneuver-and-positive-end-expiratory-pressure-in-laparoscopic-sleeve-gastrectomy-a-prospective-randomized-controlled-trial
#18
Bahattin Tuncalı, Varlık Erol, Pınar Zeyneloğlu
Background/aim: We compared the effects of volume-controlled equal ratio ventilation (VC-ERV) and volume-controlled conventional ratio ventilation (VC-CRV) on oxygenation, ventilation, respiratory mechanics, and hemodynamic status during mechanical ventilation with recruitment maneuver (RM) and positive end-expiratory pressure (PEEP) in patients undergoing laparoscopic sleeve gastrectomy. Materials and methods: A total of 111 patients scheduled for laparoscopic sleeve gastrectomy were randomized to ventilation with inspiratory to expiratory ratio of 1:1 (Group VC-ERV) or 1:2 (Group VC-CRV) following tracheal intubation...
August 16, 2018: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/30119151/detection-of-ccnd1-c-myc-and-fgfr1-amplification-using-modified-sybr-green-qpcr-and-fish-in-breast-cancer
#19
Asaad Azarnezhad, Mina Tabrizi, Firouzeh Javan, Parvin Mehdipour
Background/aim: The aims of this study were to detect CCND1 , C-MYC , and FGFR1 amplification using qPCR, confirmation with FISH, and to further assess their clinicopathological relevance. Materials and methods: Thirty-five breast tumor samples were analyzed for amplification of the selected genes using modified SYBR Green qPCR. The accuracy of the qPCR was assessed by FISH as a gold-standard method. Results: CCND1 , C-MYC , and FGFR1 amplifications were observed in 34...
August 16, 2018: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/30119150/cytoplasmic-abnormalities-of-mature-oocytes-have-a-significant-effect-on-fertilization-in-bologna-poor-responders
#20
Halenur Bozdağ, Esra Akdeniz, Belgin Devranoğlu, Murat Haksever, Bülent Emre Bilgiç, Hüseyin Tayfun Kutlu
Background/aim: We aimed to investigate whether oocyte morphologic abnormalities affected cycle outcome in poor responder infertile women who fulfilled the Bologna criteria. Materials and methods: Data were obtained from infertile couples who underwent ICSI and embryo transfer at the Zeynep Kamil Maternity and Children’s Health Training and Research Hospital Assisted Reproduction Unit in İstanbul, Turkey. They were allocated to two groups: Group A, poor responders, and Group B, normal responders...
August 16, 2018: Turkish Journal of Medical Sciences
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