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Turkish Journal of Medical Sciences

Pınar Zarakolu, Abdullah Tarık Aslan, John Perry
No abstract text is available yet for this article.
June 14, 2018: Turkish Journal of Medical Sciences
Kübra Can, Uğur Aksu, Osman Şadi Yenen
Background/aim: The aim of this study was to investigate the effects of PhiKZ phage therapy and meropenem alone or combined treatments in a pneumonia mouse model induced by the Pseudomonas aeruginosa PAO1 strain. The cross-talk between lungs and kidneys was also determined. Materials and methods: The systemic, lung-specific, and kidney-specific inflammation levels and the bacterial load in lung tissue and biochemical parameters were investigated after PhiKZ phage therapy and meropenem alone or combined treatments in a pneumonia mouse model induced by the P...
June 14, 2018: Turkish Journal of Medical Sciences
Deniz Çevirme, Taylan Adademir, Eylül Kafalı Başaran, Ömer Faruk Şavluk, Ahmet Elibol, Gözde Erkanlı Şentürk, Hatice Akkaya, Bayram Yılmaz
Background/aim: Alprostadil and iloprost are successful agents used for both pulmonary hypertension and extremity ischemia treatment. Different systemic effects of these agents may change the preferences of clinical usage. Superiority of preventing ischemia/ reperfusion (IR) injury is a criterion for clinical preference of these agents. The present study was designed to compare the protective effects of alprostadil and iloprost in a rat model of IR injury. Materials and methods: Twenty-three male Sprague Dawley rats were used (aged 8-12 weeks, mean weight 230 ± 30 g)...
June 14, 2018: Turkish Journal of Medical Sciences
Muhammet Uraloğlu, Murat Livaoğlu, Özgür Agdoğan, Şafak Ersöz, Naci Karaçal
Background/aim: Multiple zones of injuries are formed after burns, consisting of a zone of coagulative necrosis, a zone of hyperemia, and a zone of stasis, in which progressive microcirculatory thrombosis leads to degeneration and deepening of the wound. We used an experimental rat comb burn model to test the hypothesis that use of low molecular weight heparin (LMWH) may save the zone of stasis. Materials and methods: Adult female rats were randomly divided two groups: the LMWH group (n = 8) rats received subcutaneous LMWH injections, while the saline group (n = 8) rats were injected with the same volume of saline solution by the same route...
June 14, 2018: Turkish Journal of Medical Sciences
Bilsev İnce, Mehmet Dadacı, İbrahim Kılınç, Pembe Oltulu, Serhat Yarar, Mehmet Uyar
Background/aim: The aim of this study was to determine the specific component of Rosmarinus officinalis (RO) responsible for increased flap survival and how RO displays its efficacy. Materials and methods: Rectangular random-pattern flaps were elevated from the back of each rat. Group I was the control group. In group II 0.1 mL of cineole, in group III 0.1 mL of alpha-pinene, in group IV 0.1 mL of camphor, in group V 0.1 mL each of alpha-pinene and cineole, in group VI 0.1 mL each of alpha-pinene and camphor, in group VII 0...
June 14, 2018: Turkish Journal of Medical Sciences
Faize Elif Bahadır, Mustafa Kutay Köroğlu, Meral Yüksel, Feriha Ercan, Y. İnci Alican
Background/aim: This study was designed to examine the effect of tadalafil, a phosphodiesterase (PDE)5 inhibitor, on the severity of joint and muscle damage in rats with adjuvant-induced arthritis (AA). Materials and methods: AA was induced by intradermal inoculation into right hind paw of male Sprague Dawley rats (300-450g) with complete Freund's adjuvant (CFA; 0.1 mL). AA rats were treated with either tadalafil (10 mg/kg; per oral) alone or along with the soluble guanylyl cyclase inhibitor 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one (ODQ; 10 mg/kg; intraperitoneally)...
June 14, 2018: Turkish Journal of Medical Sciences
Rukiye Boran, Tuba Baygar, Nurdan Saraç, Aysel Uğur
Background/aim: The potential inhibitory effects of Ankaferd Blood Stopper (ABS) against biofilm formation of oral microorganisms and its capacity for collagenase, hyaluronidase, and elastase inhibitions that have important roles in wound healing have been investigated. Materials and methods: The wound healing potential was determined by its inhibition ability on collagenase, hyaluronidase, and elastase enzyme activities and was evaluated via scratch wound healing assay on murine 3T3 fibroblasts. The antibiofilm activity was tested against eight oral microorganisms using the crystal violet staining method...
June 14, 2018: Turkish Journal of Medical Sciences
Oğuzhan Fatih Baltacı, Şeyma Çolakoğlu, Gökçe Güllü Amuran, Neslihan Aydın, Mehmet Sarğın, Arzu Karabay, Temel Yılmaz, Ergül Berber
Background/aim: MODY3 associated with HNF1A is the most common form of MODY and is clinically misdiagnosed as type 1 diabetes due to similar clinical symptoms. This study aimed to analyze the role of HNF1A-regulated miRNAs as a biomarker in the diagnosis of MODY3. Materials and methods: MIN6 cells were transfected with the HNF1A cDNA expression vector for overexpression or with siRNA specific to HNF1A to silence its expression. The HNF1A-regulated miRNAs were determined by RNA-Seq of the total RNA extract. Expressions of the candidate miRNAs in blood samples of MODY3, type 1 diabetes, and type 2 diabetes patients and in healthy subjects were compared statistically by Mann-Whitney U tests...
June 14, 2018: Turkish Journal of Medical Sciences
Rabiye Altınbaş, Fatma Özakkaş, Ayşe Barış, Deniz Turan, Sümeyye Şen
Background/aim: Dermatophytes are the causative agents of dermatophytosis, which is a common disease worldwide that affects the hair, skin, and nails. Dermatophytes comprise more than 40 species in 3 genera: Microsporum, Trichophyton, and Epidermaphyton. In this study, we aimed to determine the effectiveness of seven antifungal agents: amphotericin B, terbinafine, itraconazole, voriconazole, ketoconazole, miconazole, and fluconazole. Materials and methods: A sensitivity study was performed using a microdilution method in accordance with the CLSI M38-A2 standards using isolates of Trichophyton rubrum (n = 55), Microsporum canis (n = 9), and Trichophyton interdigitale (n = 2), which were identified by sequencing the internal transcribed spacer region of the rDNA...
June 14, 2018: Turkish Journal of Medical Sciences
Munir Ahmad Bhinder, Muhammad Yasir Zahoor, Haleema Sadia, Muhammad Qasim, Rukhsana Perveen, Ghulam Murtaza Anjum, Muhammad Iqbal, Najeeb Ullah, Wasim Shehzad, Muhammad Tariq, Ali Muhammad Waryah
Background/aim: Genetic variation, an authentic tool of individual discrimination, is being used for forensic investigations worldwide. A missing result for even one out of 13-17 markers leads to an inconclusive report. Additional reliable markers are required to compensate such deficiencies. The SE33 locus has high genetic variability in different populations and is being used in forensic investigation systems in some countries. The purpose of the study was to assess the viability of use of the SE33 locus as a supportive marker for forensic DNA profiling...
June 14, 2018: Turkish Journal of Medical Sciences
Alper Biler, İbrahim Egemen Ertaş, Gökhan Tosun, İsmet Hortu, Ahmet Demir, Cüneyt Eftal Taner, Mehmet Özeren, Fatih Şendağ
Background/aim: This study aimed to investigate differences in perioperative complications and short-term outcomes of patients who underwent abdominal sacrocolpopexy/sacrohysteropexy, laparoscopic sacrocolpopexy/sacrohysteropexy, sacrospinous ligament fixation (SSLF), and iliococcygeus fixation due to apical prolapse. Materials and methods: The present retrospective cohort study included 145 patients who underwent apical prolapse surgery performed by the same surgeons between 1/1/2011 and 30/6/2017. There were 68 abdominal sacrocolpopexies (44 sacrocolpopexies and 24 sacrohysteropexies), 13 laparoscopic sacrocolpopexies (10 sacrocolpopexies and 3 sacrohysteropexies), 57 SSLFs, and 7 iliococcygeus fixations...
June 14, 2018: Turkish Journal of Medical Sciences
Billur Sezgin, Selahattin Özmen
Background/aim: Even though new techniques are emerging to overcome the inconsistent long-term viability of fat grafts, current methods for increasing fat graft survival are not routinely adaptable to all clinical environments. The purpose of this study was to determine the efficacy of microneedling as an adjunct to fat grafting to the face. Materials and methods: Twenty-two patients that underwent fat grafting to the face with adjunctive microneedling were evaluated in terms of improvement in facial skin quality and facial volume and their results were compared to those in 18 patients that underwent fat grafting without microneedling...
June 14, 2018: Turkish Journal of Medical Sciences
Ebru Atike Ongun, Oguz Dursun, Mehmet Saim Kazan, Banu Nur, Ercan Mıhçı
Background/aim: Declined morbidity rates after craniosynostosis surgery indicate bypassing the pediatric intensive care unit (PICU) course to minimize treatment costs and bed usage. The aim of this study is to examine the incident rates of PICU admission and assess its necessity. Materials and methods: A retrospective analysis of 41 patients (operated on by open surgical techniques) between July 2011 and December 2015 was carried out. Intraoperative/postoperative vital signs, hemodynamic and metabolic parameters, estimated blood loss (EBVloss), blood transfusions, length of PICU, and hospitalizations were recorded...
June 14, 2018: Turkish Journal of Medical Sciences
Nuran Çetin, Nadide Melike Sav
Background/aim: Chronic kidney disease (CKD), which is one of the most important health problems worldwide, could be considered as an immune inflammatory disease. A prognostic biomarker may be helpful in determining the progression of CKD in children. We aimed to investigate the serum vasohibin-1 and soluble suppression of tumorigenicity-2 (sST2) levels as potential biomarkers in children with predialysis CKD. Materials and methods: Forty-seven children with stage 2-4 CKD and 20 healthy controls were included in this cross-sectional study...
June 14, 2018: Turkish Journal of Medical Sciences
Ali Küpeli, Ayşegül Cansu, Şükrü Oğuz, Süleyman Bekirçavuşoğlu, Süha Türkmen, Ali Ahmetoğlu, Gürkan Danışan
Background/aim: This study aimed to investigate the prevalence and association of mesenteric panniculitis (MP) with other diseases and the clinicoradiological features of MP, and to examine computed tomography findings to estimate the presence of malignancy in patients with MP. Materials and methods: Between September 2012 and August 2016, we used a keyword search to identify patients diagnosed with MP. Associated diseases and malignancies of patients were recorded. Cut-off values and diagnostic efficiencies of total MP scores and short and long diameters of the greatest lymph nodes were determined...
June 14, 2018: Turkish Journal of Medical Sciences
Sezer Acar, Ahu Paketçi, Tuncay Küme, Korcan Demir, Özlem Gürsoy Çalan, Ece Böber, Ayhan Abacı
Background/aim: Galanin is a neuropeptide that is shown to be involved in the regulation of food intake and glucose homeostasis. The objective of this study was to evaluate the relation of serum galanin levels with anthropometric and metabolic parameters in obese and healthy children. Material and methods: The cross-sectional study consisted of 38 obese children (mean age: 11.9 ± 3.0 years) and 30 healthy children (mean age: 11.4 ± 2.0 years). Clinical and biochemical parameters [glucose, insulin, homeostasis model assessment-insulin resistance (HOMA-IR), lipids, galanin, and leptin levels] were assessed...
June 14, 2018: Turkish Journal of Medical Sciences
Gonca Karabulut, Gül Kitapçıoğlu, Özgün Özçaka, Esin Alpöz, Ayşe Nalbantsoy, Hayriye Koçanaoğulları, Sercan Gücenmez, Gökhan Keser, Yasemin Kabasakal
Background/aim: Abnormalities in oral mucosal immunity contribute to complex pathogenesis of primary Sjögren's syndrome (pSjS). We aimed to measure saliva and serum levels of caspase-1, tumor necrosis factor-alpha (TNF-α) and interferon gamma (IFN-γ) in patients with pSjS. Materials and methods: We studied 43 pSjS patients fulfilling the AECG criteria and 30 age/sex-matched healthy controls, as well as 39 rheumatoid arthritis (RA) patients as a disease control group. ESSDAI scores were less than seven in all patients with pSjS, indicating low disease activity...
June 14, 2018: Turkish Journal of Medical Sciences
Alp Atasoy, Evrim Çakır, Süleyman Ahbab, Yasemin Erdoğan Döventaş, Macit Koldaş, Esra Ataoğlu, Mustafa Yenigün
Background/aim: In parallel with increased frequency and higher quality of imaging techniques, the prevalence of adrenal adenoma has gradually increased. However, despite the growing incidence, the metabolic and tumorigenesis processes involved in its etiology are still unclear. Although visfatin has been reported to be associated with inflammation and tumorigenesis, its role in adrenal adenoma has not yet been investigated. Therefore, the present study was performed with an aim to evaluate visfatin levels and cardiometabolic risk factors in patients with adrenal adenoma...
June 14, 2018: Turkish Journal of Medical Sciences
Adnan Taş, Mehmet Suat Yalçın, Bünyamin Sarıtaş, Banu Kara
Background/aim: There are various scoring systems for evaluating prognosis in patients hospitalized in intensive care units (ICUs) with hepatic encephalopathy. These include the Child-Turcotte-Pugh (CTP) classification, Model for End-stage Liver Disease (MELD), chronic liver failure-sequential organ failure assessment (CLIF-SOFA), and Acute Physiology and Chronic Health Evaluation II (APACHE II). In this study, we aimed to compare the various scoring systems to determine the best system for showing the prognosis of patients with a prior diagnosis of cirrhosis who were hospitalized for hepatic encephalopathy...
June 14, 2018: Turkish Journal of Medical Sciences
Metin Dinçer
Background/aim: The aim of this study is to evaluate why dementia patients (DPs) are admitted to a palliative care center (PCC) and which factors affect the length of stay (LOS) of DPs in the PCC, and to predict the course of the disease. Materials and methods: The files of DPs were scanned retrospectively in the PCC between 2013 and 2016. Data related to age, sex, LOS, symptoms, clinical conditions, comorbidities, and prognosis were recorded. Results: The study included 85 DPs with a mean age of 84.1 ± 6...
June 14, 2018: Turkish Journal of Medical Sciences
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