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Turkish Journal of Medical Sciences

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https://www.readbyqxmd.com/read/28618769/association-study-of-ctla-4-49a-g-gene-polymorphism-with-recurrent-pregnancy-loss-in-the-iranian-azeri-turkish-ethnic-group
#1
Mortaza Bonyadi, Sara Parsa, Simin Taghavi, Narges Zeinalzadeh
BACKGROUND/AIM: Recurrent pregnancy loss (RPL) is defined as two or more pregnancy losses. T-regulatory cells play an important role in the feto-maternal interface. Cytotoxic-T-lymphocyte antigen-4 (CTLA-4) is a molecule that downregulates the activation and proliferation of T cells. The objective of the current study was to investigate the possible association of CTLA-4+49A/G gene polymorphism with RPL among patients from the Iranian Azeri Turkish ethnic group. MATERIALS AND METHODS: The study group/patients consisted of 101 women with the experience of two or more pregnancy losses and the control group consisted of 101 women with at least two live births, without any previous history of pregnancy loss and autoimmune diseases from the same ethnic group...
June 12, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/28618768/psychosocial-functioning-in-pediatric-patients-with-pectus-excavatum-and-pectus-carinatum
#2
Aliye Tuğba Bahadir, Pınar Kuru Bektaşoğlu, Aylin Çakiroğlu Eser, Ceyda Afacan, Mustafa Yüksel
BACKGROUND/AIM: Pectus excavatum and pectus carinatum are the most commonly seen anterior chest wall deformities. Recent studies reveal that minimal invasive repair of pectus deformities improves the quality of life. Our aim is to assess the psychosocial functioning and sociodemographic characteristics of pediatric patients with pectus deformities and evaluate the differences between patients operated on with minimal invasive repair techniques and nonoperated patients. MATERIALS AND METHODS:  Thirty-two patients with pectus deformities who were operated on 6 months or more before and 31 nonoperated patients participated in the study...
June 12, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/28618767/skin-findings-in-autoimmune-and-nonautoimmune-thyroid-disease-with-respect-to-thyroid-functional-status-and-healthy-controls
#3
Mümtaz Takir, Emin Özlü, Osman Köstek, Zafer Türkoğlu, Hasan Hüseyin Mutlu, Tuğba Kevser Uzunçakmak, Necmettin Akdeniz, Ayşe Serap Karadağ
BACKGROUND/AIM: Thyroid disorders are associated with a wide variety of skin disorders that respond to treatment of hormone imbalance in most cases and thus are of vital importance to dermatologists. This study aimed to evaluate skin findings associated with autoimmune and nonautoimmune thyroid disease with respect to thyroid functional status and healthy controls. MATERIALS AND METHODS: A total of 300 consecutive patients with either autoimmune (n = 173) or nonautoimmune (n = 127) thyroid disease and 100 healthy control subjects were included in this cross-sectional study...
June 12, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/28618766/relationship-between-blood-glucose-levels-and-cardiovascular-risk-in-the-spanish-mediterranean-population
#4
Ángel Arturo López-González, Zoe Manzanero, María Teófila Vicente-Herrero, Sheila García-Agudo, María Gil-Llinás, Francisco Moreno-Morcillo
BACKGROUND/AIM: Diabetes is associated with an increased prevalence of cardiovascular disease. Impaired fasting glucose (IFG) is an intermediate clinical situation between normal glucose levels and type 2 diabetes. The aim of this study is to determine how fasting glucose concentrations affect different cardiovascular risk scales. MATERIALS AND METHODS: A descriptive study was conducted with 59,041 Mediterranean Spanish workers. IFG was determined using the American Diabetes Association (ADA) and the World Health Organization (WHO) criteria...
June 12, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/28618765/the-influence-of-intraabdominal-pressure-on-the-mortality-rate-of-patients-with-acute-pancreatitis
#5
Petar Svorcan, Maja Stojanovic, Predrag Stevanovic, Aleksadar Karamarkovic, Radmilo Jankovic, Nebojsa Ladjevic
BACKGROUND/AIM: Intraabdominal hypertension (IAH) is a common clinical finding in patients with acute pancreatitis and is associated with poor prognosis. This study aimed to determine the impact of intraabdominal pressure (IAP) on the mortality rate in patients with acute pancreatitis in an intensive care unit. MATERIALS AND METHODS: A total of 50 patients with acute pancreatitis were included in this prospective cohort study. Based on the obtained values of IAP, the patients were divided into two groups: those with normal IAP (n = 14) and increased IAP (n = 36)...
June 12, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/28618764/what-is-the-rectal-colonization-rate-of-carbapenem-resistant-enterobacteriaceae-cre-infected-patients-what-is-the-decolonization-rate-of-cre-colonized-patients-in-the-hospital
#6
Fatma Feriha Çilli, Bilgin Arda, Ayşe Uyan, Münevver Kayin, Demet Dikiş, Nilay Korkmaz, Nilgün Deniz Küçükler, Nurhayat Kepeli, Behiye Ulusoy, Şükran Akşit Barik, Mehmet Ali Özinel, Sercan Ulusoy, Oğuz Reşat Sipahi
No abstract text is available yet for this article.
June 12, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/28618763/comparison-of-endothelin-and-nitric-oxide-synthase-blockers-on-hemorheological-parameters-in-endotoxemic-rats
#7
Neslihan H Dikmenoğlu Falkmarken, Okan Arihan, Alper B Iskit
BACKGROUND/AIM: Septic shock is an important health problem that vastly alters cardiovascular and hemodynamic status. Increased production of nitric oxide (NO) and endothelin is a counterpart of this endotoxemic state. This study was conducted to test the hypothesis that nonselective NO synthesis blocker (L-NAME), inducible NO synthesis blocker (L-canavanine), or endothelin receptor antagonist (bosentan) will reverse the effects of sepsis on hemorheological parameters. MATERIALS AND METHODS: Forty-eight male Sprague-Dawley rats were used in 8 groups: saline (control), endotoxin, bosentan, L-NAME, L-canavanine, endotoxin + bosentan, endotoxin + L-NAME, and endotoxin + L-canavanine...
June 12, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/28618762/antiinflammatory-and-antioxidant-effects-of-gemcitabine-in-collagen-induced-arthritis-model
#8
Adile Ferda Dağli, Ahmet Karataş, Cemal Orhan, Mehmet Tuzcu, Metin Özgen, Kazım Şahin, Süleyman Serdar Koca
BACKGROUND/AIM: Gemcitabine (GEM) has antiproliferative effects on lymphocytes, which are potent pathogenic actors of rheumatoid arthritis (RA). The aim of the study was to investigate the therapeutic potential of GEM on collagen-induced arthritis (CIA). MATERIALS AND METHODS: Arthritis was induced by the intradermal injection of chicken type II collagen with incomplete Freund's adjuvant into albino Wistar rats. Doses of 5 and 20 mg/kg GEM were administered twice a week after the 14th day, which marked the onset the arthritis...
June 12, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/28618761/the-effects-of-iloprost-and-alprostadil-on-ischemia-reperfusion-injury-in-preventing-inflammation-tissue-degeneration-and-apoptosis-in-rat-skeletal-muscle
#9
Elif Güneysu, Atacan Emre Koçman, Orhan Özatik, Cengiz Ovali, Betül Can, İbrahim Özkan Alataş, Mustafa Behçet Sevin
BACKGROUND/AIM: The protective effects of prostaglandin (PG) analogs on ischemia-reperfusion (I/R) have been well documented; however, comparative studies are lacking. The aim of the present study was to determine whether iloprost or alprostadil is more effective in preventing muscle I/R injury. MATERIALS AND METHODS: Thirty-two rats were divided into four groups (n = 8): sham, control, IL (I/R + iloprost), and AL (I/R + alprostadil). I/R was induced by a tourniquet in the hindlimb for 3 h/3 h...
June 12, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/28618760/changes-in-the-serum-liver-and-renal-cortical-lipids-and-electrolytes-in-rabbits-with-cisplatin-induced-nephrotoxicity
#10
Abdelgayoum Ahmed Abdel-Gayoum, Mohamed Hamza Sulaiman Ahmida
BACKGROUND/AIM: Cisplatin is an anticancer drug that can induce nephrotoxicity. Its toxicity is associated with dyslipidemia and disturbed electrolyte balance. In the present study we investigated the changes in serum lipid profile and electrolyte levels and their contents in kidney and liver tissues of rabbits treated with cisplatin. MATERIALS AND METHODS: Twenty-eight adult male New Zealand White rabbits were used in the experiment. Animals of groups C, P1, and P2 were injected with saline, cisplatin (4...
June 12, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/28618759/the-effect-of-trimetazidine-on-renal-oxidative-stress-in-partial-and-complete-ureteral-obstructions-in-a-rat-model
#11
Sema Nur Ayyildiz, Ali Ayyildiz, Erdal Benli, Selma Cirrik, Rüştü Cankon Germiyanoğlu, Tevfik Noyan, Abdullah Çirakoğlu
BACKGROUND/AIM: Renal oxidative stress occurs in ureteral obstructions. The purpose of this study was to investigate the effect of the antioxidant and antiischemic agent trimetazidine (TMZ) on oxidative stress following ureteral obstruction. MATERIALS AND METHODS: Ten groups were established. Sham groups were checked as controls after 1 and 3 weeks. The other 8 groups had partial or complete ureteral obstruction while receiving or not receiving trimetazidine (TMZ) at 5 mg/kg daily and were evaluated after either 1 week or 3 weeks...
June 12, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/28618758/investigation-of-the-behavioral-and-neurochemical-effects-of-monosodium-glutamate-on-neonatal-rats
#12
Ayşen Çetin Kardeşler, Eyüp Başkale
BACKGROUND/AIM: The objective of this study was to investigate and analyze the behavioral and neurochemical effects of monosodium glutamate (MSG) injections at various and subsequent dosages on male Wistar rats during the neonatal period. MATERIALS AND METHODS: In order to determine the behavioral and neurochemical effects of MSG, the experiment was implemented on neonatal male Wistar rats and the test was repeated for various MSG dosages. After completing the experiment, additionally, levels of dopamine, GABA, catecholamine (dopamine, noradrenaline, and adrenaline) and glutamate in the brain cells of the decapitated rats were also measured using the ELISA method...
June 12, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/28618757/the-effect-of-acetylsalicylic-acid-on-vasopressin-serum-insulin-levels-insulin-resistance-and-biochemical-parameters-in-rats-induced-with-experimental-diabetes-type-2
#13
Serkan Şen, Sefa Çelik
BACKGROUND/AIM: Acetylsalicylic acid (ASA) treatment in diabetic patients is very important owing to the increasing hyperactivity of thrombocytes and atherosclerosis. In several investigations, it was reported that diabetes caused increased coronary artery disease, cerebrovascular disease, and death. In this study, we aimed to investigate the effect of ASA on osmoregulation, glycemic control, and some biochemical parameters in rats induced with experimental diabetes type 2. MATERIALS AND METHODS: Twenty-four rats were randomly divided in four groups: control (I), ASA control (II), diabetic (III), and ASA diabetic (IV)...
June 12, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/28618756/rational-design-of-rabies-vaccine-formulation-for-enhanced-stability
#14
Veysel Kayser, Alain Françon, Hervé Pinton, Jean-François Saluzzo, Bernhardt L Trout
BACKGROUND/AIM: Vaccines are often lyophilized in order to retain their stability and efficacy for a longer period of time. However, the same lyophilization process may also cause a major degradation of the vaccine, especially during early phases of manufacturing, leading to a loss of potency of the product. Many viral diseases, such as rabies, are acute and fatal unless the vaccine is administered prior to exposure or the onset of symptoms in the case of postexposure treatment. MATERIALS AND METHODS: We investigated the effect of lyophilization on the stability of the virus structure during rabies vaccine manufacturing using dynamic light scattering and transmission electron microscopy...
June 12, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/28618755/isolation-rates-and-antibiotic-susceptibilities-of-different-enterobacteriaceae-species-as-urinary-tract-infection-agents-in-turkey-a-systematic-review
#15
Caner Yürüyen, Yeşim Gürol, Sabire Ferda Kaleağasioğlu, Elif Çiğdem Kaspar, Gülden Yilmaz
BACKGROUND/AIM: In Turkey, few systematic reviews have analyzed the results of studies on the isolation rates of urinary tract infection agents and their antibiotic susceptibilities. This review was done to fill this gap and enable the correct application of guideline-based medical therapy by determining the isolation rates and antibiotic susceptibilities of different Enterobacteriaceae species in Turkey. MATERIALS AND METHODS: Relevant studies found from various databases with the help of previously specified search strategies were examined and eliminated according to eligibility criteria...
June 12, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/28618754/evaluation-and-comparison-of-radiologic-pathologic-findings-in-invasive-cribriform-carcinoma-of-the-breast
#16
Pınar Balci, Işıl Başara Akin, Nevin Köremezli, Merih Güray Durak, Canan Altay, Naciye Sinem Gezer, Ali İbrahim Sevinç
BACKGROUND/AIM: This study aimed to report invasive cribriform carcinoma (ICC) with radiological and histopathologic correlations. MATERIALS AND METHODS: Seventy patients with ICC were classified into two groups; pure ICC patients and patients with >50% cribriform carcinoma component were included in group 1, while patients with <50% cribriform carcinoma component were included in group 2. All patients were reviewed according to American College of Radiology (ACR) breast imaging reporting and data system (BI-RADS) lexicon of mammography (MG), ultrasonography (US), and magnetic resonance imaging (MRI)...
June 12, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/28618753/development-of-a-new-real-time-pcr-screening-kit-for-hbs-and-common-beta-thalassemia-mutations-observed-in-turkey
#17
Derya Kan Karaer, Mehmet Ali Ergün, Hatice Ilgın Ruhi, Jale Öztürk, Halil Kara, Deniz Reisoğlu Çakmak, Talihanur Aydoğmuş, Emriye Ferda Perçin
BACKGROUND/AIM: IVSI-110 (G>A), IVSI-6 (T>C), IVSII-1 (G>A), IVSII-745 (C>G), IVSI-1 (G>A), and HbS are mutations covering 76% of all the β-globin mutations in the Turkish population. In this study, our aim is to develop a reliable, fast, real-time kit for these mutations using the TaqMan probe method. MATERIALS AND METHODS: This study included 100 individuals with beta-thalassemia or sickle cell anemia who had unknown mutations, and 21 controls with known mutations...
June 12, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/28618752/a-comparison-of-culture-and-pcr-methods-for-identifying-propionibacterium-acnes-in-lesions-isolated-from-patients-with-acne
#18
Negin Naghdi, Masood Ghane
BACKGROUND/AIM: One of the factors that affect the occurrence of acne is the presence of Propionibacterium acnes. The present study was conducted to compare the culture and polymerase chain reaction (PCR) methods for identifying P. acnes in lesions isolated from patients with acne. MATERIALS AND METHODS: To examine the presence of P. acnes, 70 samples of acne lesions were collected. Microbial culture and the PCR molecular technique were used to identify P. acnes...
June 12, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/28618751/frequency-and-molecular-characterization-of-human-norovirus-in-erzurum-turkey
#19
Mehmet Özkan Timurkan, Hakan Aydin, Osman Aktaş
BACKGROUND/AIM: There are limited studies on genotyping and phylogenetic analysis of norovirus in Turkey, and this has not previously been studied in the Eastern Anatolia region. The aim of the present study was to determine the norovirus profile in this region with genotyping and phylogenetic analysis. MATERIALS AND METHODS: Included in the study were stool samples obtained from 427 people from different age groups in Eastern Anatolia. The nucleic acid samples isolated by the automatic system and nucleic acid sequence reactions and phylogenetic analyses were performed on RNA samples...
June 12, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/28618750/morphometric-study-of-the-true-s1-and-s2-of-the-normal-and-dysmorphic-sacralized-sacra
#20
Ayşegül Firat, Kadir Bahadır Alemdaroğlu, Ahmet Özmeriç, Mehmet Yücens, Dinçer Göksülük
BACKGROUND/AIM: This study aimed to generate data for the S1 and S2 alar pedicle and body and the alar orientations for both dysmorphic and normal sacra. MATERIALS AND METHODS: The study comprised two groups: Group N consisted of 53 normal sacra and Group D included 10 dysmorphic sacra. Various features such as alar pedicle circumference; anterior, middle, and posterior axis of the sacral ala; sacral body height and width; and sagittal thickness were measured. RESULTS: In group N, the median anterior axis of the alae was observed to be 30° on the right and 25° on the left, the median midline axis was found to be 20° on the right and 15° on the left, and the median posterior alar axis was -15° on the right and -20° on the left...
June 12, 2017: Turkish Journal of Medical Sciences
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