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Journal of Prevention of Alzheimer's Disease

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https://www.readbyqxmd.com/read/29188861/antioxidants-in-the-diet-and-cognitive-function-which-role-for-the-mediterranean-life-style
#1
C Vassalle, L Sabatino, A Pingitore, K Chatzianagnostou, F Mastorci, R Ceravolo
This review aims to focus on main antioxidants- abundantly contained in the diet- as well as of the whole Mediterranean diet and life-style and their relationship with cognitive function, especially critical in two phases of life, in children until adolescence and oldness. The role of emerging biochemical and molecular biomarkers as opportunity to estimate more accurately nutritional assumption and requirement, in terms of cognitive preservation and disease risk, will be also discussed. The cluster of factors within the Mediterranean pattern -which include not only nutritional, but also physical, social, and stimulating aspects- is still largely understudied as a whole, but it is proposed as attractive research area and tool for public health planning of prevention and intervention...
2017: Journal of Prevention of Alzheimer's Disease
https://www.readbyqxmd.com/read/29188860/a-keto-mediet-approach-with-coconut-substitution-and-exercise-may-delay-the-onset-of-alzheimer-s-disease-among-middle-aged
#2
B C Perng, M Chen, J C Perng, P Jambazian
BACKGROUND: Coconut oil has been widely used to improve health because there is much information available by word of mouth, in books, and on the internet. However, researchers still continue to search for the best diets to improve the quality of life, especially for people with cognitive decline. OBJECTIVES: The aim of this review is to develop a novel dietary approach, the Keto-Mediet, which may help prevent the onset of Alzheimer's disease. METHODS: Evidence gained through literature review from 1982 to 2015 on gene-by-diet interaction and lipid and glucose metabolism in the brains of Alzheimer's patients is converted into the new Keto-Mediet approach...
2017: Journal of Prevention of Alzheimer's Disease
https://www.readbyqxmd.com/read/29188859/cognitive-performance-does-not-limit-physical-activity-participation-in-the-lifestyle-interventions-and-independence-for-elders-pilot-study-life-p
#3
K F Reid, M P Walkup, J A Katula, K M Sink, S Anton, R Axtell, D R Kerwin, A C King, F Kramer, M E Miller, V Myers, C Rosano, S A Studenski, O L Lopez, J Verghese, R A Fielding, J Williamson
OBJECTIVES: We examined whether multiple domains of baseline cognitive performance were associated with prospective physical activity (PA) adherence in the Lifestyle Interventions and Independence for Elders Pilot study (LIFE-P). DESIGN, SETTING, PARTICIPANTS: The LIFE-P study was a single-blind, multicenter, randomized controlled trial of a PA intervention compared to a successful aging educational intervention in sedentary, mobility-limited older adults. INTERVENTION: A 12-month structured, moderate-intensity, multi-modal PA program that included walking, resistance training, and flexibility exercises...
2017: Journal of Prevention of Alzheimer's Disease
https://www.readbyqxmd.com/read/29188858/modest-overweight-and-healthy-dietary-habits-reduce-risk-of-dementia-a-nationwide-survey-in-taiwan
#4
C-Y Lee, Y Sun, H-J Lee, T-F Chen, P-N Wang, K-N Lin, L-Y Tang, C-C Lin, M-J Chiu
BACKGROUND: Evidence of the associations of dietary habits and body mass index with dementia is inconsistent and limited in East Asian countries. OBJECTIVE: We aim to explore the associations of dietary habits and body mass index with the odds of dementia. DESIGN: Cross-sectional observational study. SETTING: A nationwide, population-based, door-to-door, in-person survey. PARTICIPANTS: Selected by computerized random sampling from all 19 counties in Taiwan...
2017: Journal of Prevention of Alzheimer's Disease
https://www.readbyqxmd.com/read/29188857/assessing-the-relationship-between-vitamin-d-status-and-impairments-in-cognitive-and-physical-performance-in-older-adults-using-a-dual-task-physical-performance-test
#5
J Lopez, A Campa, J E Lewis, F G Huffman, J P Liuzzi, T Li, A H Martinez, S M Ferris, A Rasul, A Farooqi, A M Lopez Medrano, S E Atlas, E Tiozzo, J Konefal, J M Woolger
BACKGROUND: Vitamin D deficiency has been associated with an increased risk of falls in older adults. Several studies have demonstrated an association between vitamin D deficiency and gait and cognitive impairments, which are two risk factors for falls in the elderly. There is lack of research about the role of vitamin D in cognitive function in the context of mobility. OBJECTIVE: The purpose of this study was to evaluate the association between vitamin D status with the age-related changes in mobility through higher order cognitive function using a dual task physical performance test...
2017: Journal of Prevention of Alzheimer's Disease
https://www.readbyqxmd.com/read/29188856/stimulus-locked-lateralized-readiness-potential-and-performance-useful-markers-for-differentiating-between-amnestic-subtypes-of-mild-cognitive-impairment
#6
S Cid-Fernández, M Lindín, F Díaz
BACKGROUND: The findings of previous studies, in which event-related potentials (ERPs) related to stimulus evaluation were measured, do not fully explain the behavioral decline observed in amnestic mild cognitive impairment (aMCI; prodromal stage of Alzheimer's Disease). OBJECTIVES: Motor ERPs were evaluated in this study with the aim of discovering complementary explanations and identifying aMCI biomarkers. DESIGN: Cross-sectional study. SETTING: Santiago de Compostela, Galicia, Spain...
2017: Journal of Prevention of Alzheimer's Disease
https://www.readbyqxmd.com/read/29188855/ginkgo-biloba-extract-consumption-and-long-term-occurrence-of-death-and-dementia
#7
J F Dartigues, L Grasset, C Helmer, C Féart, L Letenneur, H Jacqmin-Gadda, P Joly, H Amieva
OBJECTIVES: To study the benefit of Ginkgo Biloba Extract (GBe) consumption on the long term risk of dementia and death in elderly people. DESIGN: The Paquid study is a population-based cohort with regular follow-up screenings up to twenty-two years and systematic detection of incident cases of dementia. Statistical analysis was conducted with an illness-death model dealing with interval censoring of dementia and competing risk of death. SETTING: The sample was randomly selected from electoral rolls in two administrative areas of southwestern France in 1988-1989...
2017: Journal of Prevention of Alzheimer's Disease
https://www.readbyqxmd.com/read/29188854/short-term-impact-of-a-combined-nutraceutical-on-cognitive-function-perceived-stress-and-depression-in-young-elderly-with-cognitive-impairment-a-pilot-double-blind-randomized-clinical-trial
#8
A F Cicero, M Bove, A Colletti, M Rizzo, F Fogacci, M Giovannini, C Borghi
BACKGROUND: The prevalence of senile dementia is increasing worldwide, especially in the developed countries. Nevertheless, drug therapy isn't often enough to treat this condition. Researchers are evaluating the possible impact of a preventive approach, based on an improvement of lifestyle and the intake of micronutrients. Moreover, there is an increasing interest for combined nutraceuticals that can act as memory and learning enhancers, with a significant and beneficial potential on the cognitive disorders...
2017: Journal of Prevention of Alzheimer's Disease
https://www.readbyqxmd.com/read/29188853/computerized-cognitive-testing-for-use-in-clinical-trials-a-comparison-of-the-nih-toolbox-and-cogstate-c3-batteries
#9
R F Buckley, K P Sparks, K V Papp, M Dekhtyar, C Martin, S Burnham, R A Sperling, D M Rentz
BACKGROUND: As prevention trials for Alzheimer's disease move into asymptomatic populations, identifying older individuals who manifest the earliest cognitive signs of Alzheimer's disease is critical. Computerized cognitive testing has the potential to replace current gold standard paper and pencil measures and may be a more efficient means of assessing cognition. However, more empirical evidence about the comparability of novel computerized batteries to paper and pencil measures is required...
2017: Journal of Prevention of Alzheimer's Disease
https://www.readbyqxmd.com/read/29186282/ethical-issues-in-the-development-of-readiness-cohorts-in-alzheimer-s-disease-research
#10
R Milne, E Bunnik, K Tromp, S Bemelmans, S Badger, D Gove, M Maman, M Schermer, L Truyen, C Brayne, E Richard
There is growing interest in the development of novel approaches to secondary prevention trials in Alzheimer's disease to facilitate screening and recruitment of research participants and to reduce the time and costs associated with clinical trials. Several international research collaborations are setting up research infrastructures that link existing research cohorts, studies or patient registries to establish 'trial-ready' or 'readiness' cohorts. From these cohorts, individuals are recruited into clinical trial platforms...
2017: Journal of Prevention of Alzheimer's Disease
https://www.readbyqxmd.com/read/29186281/eu-us-ctad-task-force-lessons-learned-from-recent-and-current-alzheimer-s-prevention-trials
#11
P Aisen, J Touchon, R Amariglio, S Andrieu, R Bateman, J Breitner, M Donohue, B Dunn, R Doody, N Fox, S Gauthier, M Grundman, S Hendrix, C Ho, M Isaac, R Raman, P Rosenberg, R Schindler, L Schneider, R Sperling, P Tariot, K Welsh-Bohmer, M Weiner, B Vellas
At a meeting of the EU/US/Clinical Trials in Alzheimer's Disease (CTAD) Task Force in December 2016, an international group of investigators from industry, academia, and regulatory agencies reviewed lessons learned from ongoing and planned prevention trials, which will help guide future clinical trials of AD treatments, particularly in the pre-clinical space. The Task Force discussed challenges that need to be addressed across all aspects of clinical trials, calling for innovation in recruitment and retention, infrastructure development, and the selection of outcome measures...
2017: Journal of Prevention of Alzheimer's Disease
https://www.readbyqxmd.com/read/29186280/facehbi-a-prospective-study-of-risk-factors-biomarkers-and-cognition-in-a-cohort-of-individuals-with-subjective-cognitive-decline-study-rationale-and-research-protocols
#12
O Rodriguez-Gomez, A Sanabria, A Perez-Cordon, D Sanchez-Ruiz, C Abdelnour, S Valero, I Hernandez, M Rosende-Roca, A Mauleon, L Vargas, M Alegret, A Espinosa, G Ortega, M Guitart, A Gailhajanet, O Sotolongo-Grau, S Moreno-Grau, S Ruiz, M Tarragona, J Serra, E Martin, E Peleja, F Lomeña, F Campos, A Vivas, M Gomez-Chiari, M A Tejero, J Giménez, P Pesini, M Sarasa, G Martinez, A Ruiz, L Tarraga, M Boada
BACKGROUND: Long-term longitudinal studies with multimodal biomarkers are needed to delve into the knowledge of preclinical AD. Subjective cognitive decline has been proposed as a risk factor for the development of cognitive impairment. Thus, including individuals with SCD in observational studies may be a cost-effective strategy to increase the prevalence of preclinical AD in the sample. OBJECTIVES: To describe the rationale, research protocols and baseline characteristics of participants in the Fundació ACE Healthy Brain Initiative (FACEHBI)...
2017: Journal of Prevention of Alzheimer's Disease
https://www.readbyqxmd.com/read/29186279/albumin-hemoglobin-and-the-trajectory-of-cognitive-function-in-community-dwelling-older-japanese-a-13-year-longitudinal-study
#13
H Murayama, S Shinkai, M Nishi, Y Taniguchi, H Amano, S Seino, Y Yokoyama, H Yoshida, Y Fujiwara, H Ito
BACKGROUND: Cognitive function can substantially decline over a long period, and understanding the trajectory of cognitive function is important. However, little is known about the linkage between nutritional biomarkers and long-term cognitive change. OBJECTIVES: We analyzed 13-year longitudinal data for older Japanese to examine the associations of serum albumin and hemoglobin levels with the trajectory of cognitive function. DESIGN: Longitudinal study...
2017: Journal of Prevention of Alzheimer's Disease
https://www.readbyqxmd.com/read/29186278/dependence-levels-as-interim-clinical-milestones-along-the-continuum-of-alzheimer-s-disease-18-month-results-from-the-geras-observational-study
#14
K Kahle-Wrobleski, J S Andrews, M Belger, W Ye, S Gauthier, D M Rentz, D Galasko
BACKGROUND: While functional loss forms part of the current diagnostic criteria used to identify dementia due to Alzheimer's disease, the gradual and progressive nature of the disease makes it difficult to recognize clinically relevant signposts that could be helpful in making treatment and management decisions. Having previously observed a significant relationship between stages of functional dependence (the level of assistance patients require consequent to Alzheimer's disease deficits, derived from the Alzheimer's Disease Cooperative Study - Activities of Daily Living Scale) and cognitive severity, we investigated whether measures of functional dependence could be utilized to identify clinical milestones of Alzheimer's disease progression...
2017: Journal of Prevention of Alzheimer's Disease
https://www.readbyqxmd.com/read/29186277/getting-more-clinically-meaningful-measures-of-functional-impairment-for-alzheimer-s-disease
#15
H Fillit
No abstract text is available yet for this article.
2017: Journal of Prevention of Alzheimer's Disease
https://www.readbyqxmd.com/read/29182711/evaluation-of-the-neuroprotective-potential-of-n-acetylcysteine-for-prevention-and-treatment-of-cognitive-aging-and-dementia
#16
Y Hara, N McKeehan, P A Dacks, H M Fillit
Alzheimer's disease is a progressive neurodegenerative disease for which there is no cure and only a few treatments providing little relief. Increased oxidative stress that is associated with aging is strongly implicated in the pathogenesis and progression of Alzheimer's disease. Studies have shown that levels of the endogenous antioxidant glutathione decline at an early stage of Alzheimer's disease with decreased levels correlating with worse cognitive functions. N-acetylcysteine, a drug also widely available as a dietary supplement, is a precursor of L-cysteine, which in turn is a component of glutathione...
2017: Journal of Prevention of Alzheimer's Disease
https://www.readbyqxmd.com/read/29182710/objective-cognitive-impairment-and-progression-to-dementia-in-women-the-prospective-epidemiological-risk-factor-study
#17
J Skov Neergaard, K Dragsbæk, C Christiansen, M Asser Karsdal, S Brix, K Henriksen
BACKGROUND: Identification of subjects with a progressive disease phenotype is an urgent need in the pharmaceutical industry where most of the recent clinical trials in Alzheimer's disease have failed. OBJECTIVES: The objective of this study was to identify subgroups of individuals with objective cognitive impairment (OCI), who were most likely to progress to dementia and to identify the risk factors associated with progression. DESIGN: Prospective cohort study...
2017: Journal of Prevention of Alzheimer's Disease
https://www.readbyqxmd.com/read/29182709/the-rosas-cohort-a-prospective-longitudinal-study-of-biomarkers-for-alzheimer-s-disease-strategy-methods-and-initial-results
#18
A de Mauléon, M Soto, V Kiyasova, J Delrieu, I Guignot, S Galtier, M Lilamand, C Cantet, F Lala, N Sastre, S Andrieu, M Pueyo, P J Ousset, B Vellas
OBJECTIVE: The aims of the Research Of biomarkers in Alzheimer's diseaSe (ROSAS) study were to determine the biofluid and imaging biomarkers permitting an early diagnosis of Alzheimer's disease and better characterisation of cognitive and behavioural course of the pathology. This paper outlines the overall strategy, methodology of the study, baseline characteristics of the population and first longitudinal results from the ROSAS cohort. METHODS: Longitudinal prospective monocentric observational study performed at the Alzheimer's disease Research centre in Toulouse...
2017: Journal of Prevention of Alzheimer's Disease
https://www.readbyqxmd.com/read/29182708/b-vitamin-therapy-for-kidney-transplant-recipients-lowers-homocysteine-and-improves-selective-cognitive-outcomes-in-the-randomized-favorit-ancillary-cognitive-trial
#19
T M Scott, G Rogers, D E Weiner, K Livingston, J Selhub, P F Jacques, I H Rosenberg, A M Troen
BACKGROUND: Objectives: Elevated plasma total homocysteine (tHcy) is associated with increased risk of cardiovascular disease, stroke and dementia. Results of clinical trials using B-vitamins to reduce the cognitive risks attributed to tHcy have been inconsistent. The high prevalence of both hyperhomocysteinemia and cognitive impairment among kidney transplant recipients makes them an important population in which to evaluate the effect of lowering homocysteine on cognitive function. We therefore evaluated whether B-vitamin therapy to lower tHcy would prevent cognitive-decline in a cohort of stable kidney transplant recipients...
2017: Journal of Prevention of Alzheimer's Disease
https://www.readbyqxmd.com/read/29182707/sex-and-age-differences-in-the-association-of-blood-pressure-and-hypertension-with-cognitive-function-in-the-elderly-the-rancho-bernardo-study
#20
D Kritz-Silverstein, G A Laughlin, L K McEvoy, E Barrett-Connor
OBJECTIVES: This study examines sex and age differences in associations of systolic and diastolic blood pressure (SBP, DBP), pulse pressure and hypertension with cognitive function in a community-dwelling population. DESIGN: Cross-sectional study. SETTING: Research clinic visit in 1988-91. PARTICIPANTS: Participants were 693 men and 1022 women aged 50-97 Measurements: Blood pressure was measured and 12 cognitive function tests were administered...
2017: Journal of Prevention of Alzheimer's Disease
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