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Lancet Psychiatry

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https://www.readbyqxmd.com/read/28736102/antipsychotic-drugs-for-the-acute-treatment-of-patients-with-a-first-episode-of-schizophrenia-a-systematic-review-with-pairwise-and-network-meta-analyses
#1
Yikang Zhu, Marc Krause, Maximilian Huhn, Philipp Rothe, Johannes Schneider-Thoma, Anna Chaimani, Chunbo Li, John M Davis, Stefan Leucht
BACKGROUND: The first episode of schizophrenia is a pivotal phase of this debilitating illness. Which drug to use remains controversial without a summary of all direct or indirect comparisons of drugs. We did a systematic review with pairwise and network meta-analyses of efficacy and tolerability. METHODS: We searched MEDLINE, Embase, PsycINFO, Cochrane Library, PubMed, Biosis, and ClinicalTrials.gov for randomised controlled trials of antipsychotics for the acute treatment of first-episode schizophrenia, published up to Nov 17, 2016...
July 20, 2017: Lancet Psychiatry
https://www.readbyqxmd.com/read/28736101/choice-of-antipsychotic-to-treat-first-episode-schizophrenia
#2
David Taylor
No abstract text is available yet for this article.
July 20, 2017: Lancet Psychiatry
https://www.readbyqxmd.com/read/28711282/who-qualityrights-transforming-mental-health-services
#3
Michelle Funk, Natalie Drew
No abstract text is available yet for this article.
July 12, 2017: Lancet Psychiatry
https://www.readbyqxmd.com/read/28705600/poor-medication-adherence-and-risk-of-relapse-associated-with-continued-cannabis-use-in-patients-with-first-episode-psychosis-a-prospective-analysis
#4
Tabea Schoeler, Natalia Petros, Marta Di Forti, Ewa Klamerus, Enrico Foglia, Robin Murray, Sagnik Bhattacharyya
BACKGROUND: Cannabis use following the onset of first-episode psychosis has been linked to both increased risk of relapse and non-adherence with antipsychotic medication. Whether poor outcome associated with cannabis use is mediated through an adverse effect of cannabis on medication adherence is unclear. METHODS: In a prospective analysis of data acquired from four different adult inpatient and outpatient units of the South London and Maudsley Mental Health National Health Service Foundation Trust in London, UK, 245 patients were followed up for 2 years from the onset of first-episode psychosis...
July 10, 2017: Lancet Psychiatry
https://www.readbyqxmd.com/read/28705599/psychosis-relapse-medication-non-adherence-and-cannabis
#5
John A Engh, Jørgen G Bramness
No abstract text is available yet for this article.
July 10, 2017: Lancet Psychiatry
https://www.readbyqxmd.com/read/28689019/common-versus-specific-factors-in-psychotherapy-opening-the-black-box
#6
REVIEW
Roger Mulder, Greg Murray, Julia Rucklidge
Do psychotherapies work primarily through the specific factors described in treatment manuals, or do they work through common factors? In attempting to unpack this ongoing debate between specific and common factors, we highlight limitations in the existing evidence base and the power battles and competing paradigms that influence the literature. The dichotomy is much less than it might first appear. Most specific factor theorists now concede that common factors have importance, whereas the common factor theorists produce increasingly tight definitions of bona fide therapy...
July 5, 2017: Lancet Psychiatry
https://www.readbyqxmd.com/read/28687481/prevalence-and-risk-factors-for-hiv-hepatitis-b-and-hepatitis-c-in-people-with-severe-mental-illness-a-total-population-study-of-sweden
#7
Clarissa Bauer-Staeb, Lena Jörgensen, Glyn Lewis, Christina Dalman, David P J Osborn, Joseph F Hayes
BACKGROUND: Severe mental illness is associated with increased morbidity and mortality. The elevated risk of blood-borne viruses (BBVs) in people with severe mental illness is of concern, but the full extent of this problem is unclear. We aimed to determine the prevalence of and risk factors for BBVs in people with severe mental illness. METHODS: In this nationwide, population-based, cross-sectional study, we estimated the point prevalence of HIV, hepatitis B (HBV), and hepatitis C (HCV) in people with severe mental illness, including the total adult (≥18 years) Swedish population...
July 4, 2017: Lancet Psychiatry
https://www.readbyqxmd.com/read/28687480/ending-hiv-hepatitis-b-and-hepatitis-c-what-about-people-with-severe-mental-illness
#8
Milton Wainberg, Lisa Dixon
No abstract text is available yet for this article.
July 4, 2017: Lancet Psychiatry
https://www.readbyqxmd.com/read/28668671/deutetrabenazine-for-treatment-of-involuntary-movements-in-patients-with-tardive-dyskinesia-aim-td-a-double-blind-randomised-placebo-controlled-phase-3-trial
#9
Karen E Anderson, David Stamler, Mat D Davis, Stewart A Factor, Robert A Hauser, Jouko Isojärvi, L Fredrik Jarskog, Joohi Jimenez-Shahed, Rajeev Kumar, Joseph P McEvoy, Stanislaw Ochudlo, William G Ondo, Hubert H Fernandez
BACKGROUND: Tardive dyskinesia results from exposure to dopamine receptor antagonists, such as typical and atypical antipsychotics. If clinically appropriate, clinicians often manage this disorder by lowering the dose of, or discontinuing, the causative drug. There is a significant unmet need for a treatment option that does not disrupt treatment regimens for underlying psychiatric illnesses. We aimed to assess the efficacy, safety, and tolerability of fixed doses of deutetrabenazine-a novel vesicular monoamine transporter-2 inhibitor-in patients with tardive dyskinesia...
June 28, 2017: Lancet Psychiatry
https://www.readbyqxmd.com/read/28668670/a-new-class-of-vmat-2-inhibitors-for-tardive-dyskinesia
#10
Christoph U Correll, Maren Carbon
No abstract text is available yet for this article.
June 28, 2017: Lancet Psychiatry
https://www.readbyqxmd.com/read/28647538/why-we-need-to-understand-service-variation-in-compulsion
#11
Jorun Rugkåsa
No abstract text is available yet for this article.
June 21, 2017: Lancet Psychiatry
https://www.readbyqxmd.com/read/28647537/variation-in-compulsory-psychiatric-inpatient-admission-in-england-a-cross-classified-multilevel-analysis
#12
Scott Weich, Orla McBride, Liz Twigg, Craig Duncan, Patrick Keown, David Crepaz-Keay, Eva Cyhlarova, Helen Parsons, Jan Scott, Kamaldeep Bhui
BACKGROUND: The increasing rate of compulsory admission to psychiatric inpatient beds in England is worrying. Studying variation between places and services could be key to identifying targets for interventions to reverse this trend. We modelled spatial variation in compulsory admissions in England using national patient-level data and quantified the extent to which patient, local-area, and service-setting characteristics accounted for this variation. METHODS: This study is a cross-sectional, multilevel analysis of the 2010-11 Mental Health Minimum Data Set (MHMDS)...
June 21, 2017: Lancet Psychiatry
https://www.readbyqxmd.com/read/28625876/mental-health-in-zimbabwe-a-health-systems-analysis
#13
Khameer Kidia, Debra Machando, Walter Mangezi, Reuben Hendler, Megan Crooks, Melanie Abas, Dixon Chibanda, Graham Thornicroft, Maya Semrau, Helen Jack
There has been little external analysis of Zimbabwe's mental health system. We did a systems analysis to identify bottlenecks and opportunities for mental health service improvement in Zimbabwe and to generate cost-effective, policy-relevant solutions. We combined in-depth interviews with a range of key stakeholders in health and mental health, analysis of mental health laws and policies, and publicly available data about mental health. Five themes are key to mental health service delivery in Zimbabwe: policy and law; financing and resources; criminal justice; workforce, training, and research; and beliefs about mental illness...
June 15, 2017: Lancet Psychiatry
https://www.readbyqxmd.com/read/28624180/effect-of-implementation-of-a-smoke-free-policy-on-physical-violence-in-a-psychiatric-inpatient-setting-an-interrupted-time-series-analysis
#14
Debbie Robson, Gilda Spaducci, Ann McNeill, Duncan Stewart, Tom J K Craig, Mary Yates, Lisa Szatkowski
BACKGROUND: Smoke-free policies are important to protect health and reduce health inequalities. A major barrier to policy implementation in psychiatric hospitals is staff concern that physical violence will increase. We aimed to assess the effect of implementing a comprehensive smoke-free policy on rates of physical assaults in a large UK mental health organisation. METHODS: We did an interrupted time series analysis of incident reports of physical assault 30 months before and 12 months after the implementation of the policy in the inpatient wards of South London and Maudsley National Health Service Foundation Trust, London, UK...
June 14, 2017: Lancet Psychiatry
https://www.readbyqxmd.com/read/28624179/smoke-free-policies-in-psychiatric-hospitals-need-resources
#15
Suzanne H Gage, Olivia M Maynard
No abstract text is available yet for this article.
June 14, 2017: Lancet Psychiatry
https://www.readbyqxmd.com/read/28599949/quetiapine-extended-release-versus-aripiprazole-in-children-and-adolescents-with-first-episode-psychosis-the-multicentre-double-blind-randomised-tolerability-and-efficacy-of-antipsychotics-tea-trial
#16
Anne Katrine Pagsberg, Pia Jeppesen, Dea Gowers Klauber, Karsten Gjessing Jensen, Ditte Rudå, Marie Stentebjerg-Olesen, Peter Jantzen, Simone Rasmussen, Eva Ann-Sofie Saldeen, Maj-Britt Glenn Lauritsen, Niels Bilenberg, Anne Dorte Stenstrøm, Louise Nyvang, Sarah Madsen, Thomas M Werge, Theis Lange, Christian Gluud, Maria Skoog, Per Winkel, Jens Richardt M Jepsen, Birgitte Fagerlund, Christoph U Correll, Anders Fink-Jensen
BACKGROUND: Head-to-head trials to guide antipsychotic treatment choices for paediatric psychosis are urgently needed because extrapolations from adult studies might not be implementable. In this superiority trial with two-sided significance testing, we aimed to compare the efficacy and safety of quetiapine-extended release (quetiapine-ER) versus aripiprazole in children and adolescents with first-episode psychosis, to determine whether differences between the two treatments were sufficient to guide clinicians in their choice of one drug over the other...
June 6, 2017: Lancet Psychiatry
https://www.readbyqxmd.com/read/28596067/architecture-and-functioning-of-child-and-adolescent-mental-health-services-a-28-country-survey-in-europe
#17
Giulia Signorini, Swaran P Singh, Vlatka Boricevic-Marsanic, Gwen Dieleman, Katarina Dodig-Ćurković, Tomislav Franic, Suzanne E Gerritsen, James Griffin, Athanasios Maras, Fiona McNicholas, Lesley O'Hara, Diane Purper-Ouakil, Moli Paul, Ulrike Schulze, Cathy Street, Sabine Tremmery, Helena Tuomainen, Frank Verhulst, Jane Warwick, Giovanni de Girolamo
The WHO Child and Adolescent Mental Health Atlas, published in 2005, reported that child and adolescent mental health services (CAMHS) in Europe differed substantially in their architecture and functioning. We assessed the characteristics of national CAMHS across the European Union (EU), including legal aspects of adolescent care. Using an online mapping survey aimed at expert(s) in each country, we obtained data for all 28 countries in the EU. The characteristics and activities of CAMHS (ie, availability of services, inpatient beds, and clinicians and organisations, and delivery of specific CAMHS services and treatments) varied considerably between countries, as did funding sources and user access...
June 5, 2017: Lancet Psychiatry
https://www.readbyqxmd.com/read/28578902/lithium-for-long-term-treatment-of-unipolar-depression
#18
Allan H Young
No abstract text is available yet for this article.
June 1, 2017: Lancet Psychiatry
https://www.readbyqxmd.com/read/28578901/pharmacological-treatments-and-risk-of-readmission-to-hospital-for-unipolar-depression-in-finland-a-nationwide-cohort-study
#19
Jari Tiihonen, Antti Tanskanen, Fabian Hoti, Pia Vattulainen, Heidi Taipale, Juha Mehtälä, Markku Lähteenvuo
BACKGROUND: Little is known about the comparative effectiveness of long-term pharmacological treatments for severe unipolar depression. We aimed to study the effectiveness of pharmacological treatments in relapse prevention in a nationwide cohort of patients who had been admitted to hospital at least once as a result of unipolar depression. METHODS: Our nationwide cohort study investigated the risk of readmission to hospital in 1996-2012 in all patients in Finland who had been admitted to hospital at least once for unipolar depression (without a diagnosis of schizophrenia or bipolar disorder) in Finland between Jan 1, 1987, and Dec 31, 2012...
June 1, 2017: Lancet Psychiatry
https://www.readbyqxmd.com/read/28552501/income-inequality-and-mental-illness-related-morbidity-and-resilience-a-systematic-review-and-meta-analysis
#20
Wagner Silva Ribeiro, Annette Bauer, Mário César Rezende Andrade, Marianna York-Smith, Pedro Mario Pan, Luca Pingani, Martin Knapp, Evandro Silva Freire Coutinho, Sara Evans-Lacko
BACKGROUND: Studies of the association between income inequality and mental health have shown mixed results, probably due to methodological heterogeneity. By dealing with such heterogeneity through a systematic review and meta-analysis, we examine the association between income inequality, mental health problems, use of mental health services, and resilience (defined as the ability to cope with adversity). METHODS: We searched the Global Health, PsychARTICLES, PsycINFO, Social Policy and Practice, Embase and MEDLINE databases up to July 6, 2016, for quantitative studies of the association of income inequality with prevalence or incidence of mental disorders or mental health problems, use of mental health services, and resilience...
May 25, 2017: Lancet Psychiatry
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