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Lancet Psychiatry

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https://www.readbyqxmd.com/read/27914904/from-efficacy-to-pragmatic-trials-does-the-dodo-bird-verdict-apply
#1
Joan Asarnow, Dennis Ougrin
No abstract text is available yet for this article.
November 30, 2016: Lancet Psychiatry
https://www.readbyqxmd.com/read/27914903/cognitive-behavioural-therapy-and-short-term-psychoanalytical-psychotherapy-versus-a-brief-psychosocial-intervention-in-adolescents-with-unipolar-major-depressive-disorder-impact-a-multicentre-pragmatic-observer-blind-randomised-controlled-superiority-trial
#2
Ian M Goodyer, Shirley Reynolds, Barbara Barrett, Sarah Byford, Bernadka Dubicka, Jonathan Hill, Fiona Holland, Raphael Kelvin, Nick Midgley, Chris Roberts, Rob Senior, Mary Target, Barry Widmer, Paul Wilkinson, Peter Fonagy
BACKGROUND: Psychological treatments for adolescents with unipolar major depressive disorder are associated with diagnostic remission within 28 weeks in 65-70% of patients. We aimed to assess the medium-term effects and costs of psychological therapies on maintenance of reduced depression symptoms 12 months after treatment. METHODS: We did this multicentre, pragmatic, observer-blind, randomised controlled superiority trial (IMPACT) at 15 National Health Service child and adolescent mental health service (CAMHS) clinics in three regions in England...
November 30, 2016: Lancet Psychiatry
https://www.readbyqxmd.com/read/27856397/sex-and-gender-differences-in-mental-disorders
#3
Anita Riecher-Rössler
No abstract text is available yet for this article.
November 11, 2016: Lancet Psychiatry
https://www.readbyqxmd.com/read/27856396/oestrogens-prolactin-hypothalamic-pituitary-gonadal-axis-and-schizophrenic-psychoses
#4
REVIEW
Anita Riecher-Rössler
Interest is growing in the potential effect of gonadal hormones, prolactin, and the hypothalamic-pituitary-gonadal axis in schizophrenic psychoses. Many studies from clinical, epidemiological, and fundamental research have confirmed that oestradiol, the main component of oestrogens, can have protective effects in schizophrenic psychoses. Furthermore, many patients with schizophrenic psychoses-even in the untreated prodromal stages-have hyperprolactinaemia and gonadal dysfunction, with oestrogen deficiency in women and testosterone deficiency in men...
November 11, 2016: Lancet Psychiatry
https://www.readbyqxmd.com/read/27856395/why-are-women-so-vulnerable-to-anxiety-trauma-related-and-stress-related-disorders-the-potential-role-of-sex-hormones
#5
REVIEW
Sophie H Li, Bronwyn M Graham
Increased prevalence, severity, and burden of anxiety, trauma-related and stress-related disorders in women compared with men has been well documented. Evidence from a variety of fields has emerged suggesting that sex hormones, particularly oestradiol and progesterone, play a significant part in generation of these sex differences. In this Series paper, we aim to integrate the literature reporting on the effects of sex hormones on biological, behavioural, and cognitive pathways, to propose two broad mechanisms by which oestradiol and progesterone influence sex differences in anxiety disorders: augmentation of vulnerability factors associated with anxiety disorder development; and facilitation of the maintenance of anxious symptoms post-development...
November 11, 2016: Lancet Psychiatry
https://www.readbyqxmd.com/read/27856394/gender-neutral-mental-health-research-is-sex-and-gender-biased
#6
Louise M Howard, Anna M Ehrlich, Freya Gamlen, Sian Oram
No abstract text is available yet for this article.
November 11, 2016: Lancet Psychiatry
https://www.readbyqxmd.com/read/27856393/violence-against-women-and-mental-health
#7
REVIEW
Sian Oram, Hind Khalifeh, Louise M Howard
Violence against women is widely recognised as a violation of human rights and a public health problem. In this Series paper, we argue that violence against women is also a prominent public mental health problem, and that mental health professionals should be identifying, preventing, and responding to violence against women more effectively. The most common forms of violence against women are domestic abuse and sexual violence, and victimisation is associated with an increased risk of mental disorder. Despite clinical guidance on the role of mental health professionals in identifying violence against women and responding appropriately, poor identification persists and can lead to non-engagement with services and poor response to treatment...
November 11, 2016: Lancet Psychiatry
https://www.readbyqxmd.com/read/27856392/why-is-depression-more-common-among-women-than-among-men
#8
REVIEW
Christine Kuehner
Women are about twice as likely as are men to develop depression during their lifetime. This Series paper summarises evidence regarding the epidemiology on gender differences in prevalence, incidence, and course of depression, and factors possibly explaining the gender gap. Gender-related subtypes of depression are suggested to exist, of which the developmental subtype has the strongest potential to contribute to the gender gap. Limited evidence exists for risk factors to be specifically linked to depression...
November 11, 2016: Lancet Psychiatry
https://www.readbyqxmd.com/read/27838214/reduction-or-discontinuation-of-antipsychotics-for-challenging-behaviour-in-adults-with-intellectual-disability-a-systematic-review
#9
REVIEW
Rory Sheehan, Angela Hassiotis
The use of antipsychotics to manage challenging behaviour in adults with intellectual disability is widespread but controversial, and evidence is scarce. There is a perception that antipsychotics used in this context can be reduced or discontinued, and this has been a major focus of recent national policy. However, such an intervention risks harm as well as having potential benefits. We reviewed the available evidence and found that antipsychotics can be reduced or discontinued in a substantial proportion of adults who use them for challenging behaviour, although not always without adverse effects...
November 9, 2016: Lancet Psychiatry
https://www.readbyqxmd.com/read/27816568/scenarios-for-the-future-of-mental-health-care-a-social-perspective
#10
REVIEW
Domenico Giacco, Michaela Amering, Victoria Bird, Thomas Craig, Giuseppe Ducci, Jürgen Gallinat, Steven George Gillard, Tim Greacen, Phil Hadridge, Sonia Johnson, Nikolina Jovanovic, Richard Laugharne, Craig Morgan, Matthijs Muijen, Georg Schomerus, Martin Zinkler, Simon Wessely, Stefan Priebe
Social values and concepts have played a central role in the history of mental health care. They have driven major reforms and guided the development of various treatment models. Although social values and concepts have been important for mental health care in the past, this Personal View addresses what their role might be in the future. We (DG, PH, and SP) did a survey of professional stakeholders and then used a scenario planning technique in an international expert workshop to address this question. The workshop developed four distinct but not mutually exclusive scenarios in which the social aspect is central: mental health care will be patient controlled; it will target people's social context to improve their mental health; it will become virtual; and access to care will be regulated on the basis of social disadvantage...
November 2, 2016: Lancet Psychiatry
https://www.readbyqxmd.com/read/27726983/placebo-response-in-depression-is-it-rising
#11
Paul Enck
No abstract text is available yet for this article.
October 7, 2016: Lancet Psychiatry
https://www.readbyqxmd.com/read/27726982/placebo-response-rates-in-antidepressant-trials-a-systematic-review-of-published-and-unpublished-double-blind-randomised-controlled-studies
#12
Toshi A Furukawa, Andrea Cipriani, Lauren Z Atkinson, Stefan Leucht, Yusuke Ogawa, Nozomi Takeshima, Yu Hayasaka, Anna Chaimani, Georgia Salanti
BACKGROUND: Previous studies have shown that placebo response rates in antidepressant trials have been increasing since the 1970s. However, these studies have been based on outdated or limited datasets and have used inappropriate statistical methods. We did a systematic review of placebo-controlled randomised controlled trials of antidepressants to examine associations between placebo-response rates and study and patient characteristics. METHODS: In this systematic review, we searched for published and unpublished double-blind randomised placebo-controlled trials of first-generation and second-generation antidepressants for acute treatment of major depression in adults (update: Jan 8, 2016)...
October 7, 2016: Lancet Psychiatry
https://www.readbyqxmd.com/read/27720402/the-association-between-first-episode-psychosis-and-abnormal-glycaemic-control-systematic-review-and-meta-analysis
#13
Benjamin Ian Perry, Gemma McIntosh, Scott Weich, Swaran Singh, Karen Rees
BACKGROUND: Schizophrenia might share intrinsic inflammatory disease pathways with type 2 diabetes. We aimed to assess whether first-episode psychosis, which could be described as developing schizophrenia, is associated with prediabetic markers, or developing diabetes, to determine whether intrinsic disease links could cause the disorders to develop in unison. We hypothesised that biochemical measures of prediabetic states would be more common in antipsychotic naive patients with first-episode psychosis than in healthy matched controls...
October 5, 2016: Lancet Psychiatry
https://www.readbyqxmd.com/read/27720401/schizophrenia-and-metabolic-dysregulation-shared-roots
#14
Mehrul Hasnain
No abstract text is available yet for this article.
October 5, 2016: Lancet Psychiatry
https://www.readbyqxmd.com/read/27697514/time-varying-associations-of-suicide-with-deployments-mental-health-conditions-and-stressful-life-events-among-current-and-former-us-military-personnel-a-retrospective-multivariate-analysis
#15
Yu-Chu Shen, Jesse M Cunha, Thomas V Williams
BACKGROUND: US military suicides have increased substantially over the past decade and currently account for almost 20% of all military deaths. We investigated the associations of a comprehensive set of time-varying risk factors with suicides among current and former military service members. METHODS: We did a retrospective multivariate analysis of all US military personnel between 2001 and 2011 (n=110 035 573 person-quarter-years, representing 3 795 823 service members)...
September 30, 2016: Lancet Psychiatry
https://www.readbyqxmd.com/read/27688022/early-group-psychoeducation-for-bipolar-disorder
#16
Eduard Vieta, Ivette Morilla
No abstract text is available yet for this article.
September 26, 2016: Lancet Psychiatry
https://www.readbyqxmd.com/read/27889012/corrections
#17
(no author information available yet)
No abstract text is available yet for this article.
December 2016: Lancet Psychiatry
https://www.readbyqxmd.com/read/27889011/limb-amputation-and-other-disability-desires-as-a-medical-condition
#18
REVIEW
Peter Brugger, Markus Christen, Lena Jellestad, Jürgen Hänggi
Some people have a profound dissatisfaction with what is considered an able-bodied state by most others. These individuals desire to be disabled, by conventional standards. In this Review, we integrate research findings about the desire for a major limb amputation or paralysis (xenomelia). Neuropsychological and neuroimaging explorations of xenomelia show functional and structural abnormalities in predominantly right hemisphere cortical circuits of higher-order bodily representation, including affective and sexual aspects of corporeal awareness...
December 2016: Lancet Psychiatry
https://www.readbyqxmd.com/read/27889010/neuropsychiatric-aspects-of-concussion
#19
REVIEW
Rajiv Radhakrishnan, Amir Garakani, Lawrence S Gross, Marcia K Goin, Janet Pine, Andrew E Slaby, Calvin R Sumner, David A Baron
Over the past decade, concussion has become the most widely discussed injury in contact sports. However, concussions also occur in several other settings, such as non-contact sports, elderly individuals, young children, military personnel, and victims of domestic violence. Concussion is frequently undiagnosed as a cause of psychiatric morbidity, especially when the patient has no history of loss of consciousness or direct head trauma. Almost all of the extant literature focuses on traumatic brain injury and assumes that concussion is merely a mild form of traumatic brain injury, which has resulted in a lack of understanding about what concussion is, and how to diagnose, monitor, and treat its varied neuropsychiatric symptoms...
December 2016: Lancet Psychiatry
https://www.readbyqxmd.com/read/27889009/a-wonderful-lie
#20
Christopher Boyle, Kathy McKay
No abstract text is available yet for this article.
December 2016: Lancet Psychiatry
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