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Lancet Psychiatry

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https://www.readbyqxmd.com/read/28189575/trajectories-of-relapse-in-randomised-placebo-controlled-trials-of-treatment-discontinuation-in-major-depressive-disorder-an-individual-patient-level-data-meta-analysis
#1
Ralitza Gueorguieva, Adam M Chekroud, John H Krystal
BACKGROUND: Understanding patterns of relapse in patients who respond to antidepressant treatment can inform strategies for prevention of relapse. We aimed to identify distinct trajectories of depression severity, assess whether similar or different trajectory classes exist for patients who continued or discontinued active treatment, and test whether clinical predictors of trajectory class membership exist using pooled data from clinical trials. METHODS: We analysed individual patient data from four double-blind discontinuation clinical trials of duloxetine or fluoxetine versus placebo in major depression from before 2012 (n=1462)...
February 8, 2017: Lancet Psychiatry
https://www.readbyqxmd.com/read/28189574/symptom-trajectories-in-discontinuation-trials
#2
Michael Browning
No abstract text is available yet for this article.
February 8, 2017: Lancet Psychiatry
https://www.readbyqxmd.com/read/28185901/cognition-in-psychiatric-disorders-from-models-to-management
#3
Michael Berk, Lesley Berk
No abstract text is available yet for this article.
February 6, 2017: Lancet Psychiatry
https://www.readbyqxmd.com/read/28185900/evidence-based-science-policy-for-mental-health-in-a-post-truth-era
#4
Harold Alan Pincus, Stephanie A Rolin
No abstract text is available yet for this article.
February 6, 2017: Lancet Psychiatry
https://www.readbyqxmd.com/read/28185899/lurasidone-versus-treatment-as-usual-for-cognitive-impairment-in-euthymic-patients-with-bipolar-i-disorder-a-randomised-open-label-pilot-study
#5
Lakshmi N Yatham, Sylvia Mackala, Jayasree Basivireddy, Sharon Ahn, Nazlin Walji, Chen Hu, Raymond W Lam, Ivan J Torres
BACKGROUND: Cognitive impairment is present in euthymic patients with bipolar disorder and correlates with impairments in everyday functioning. We aimed to examine the efficacy of lurasidone adjunctive therapy compared with treatment as usual (TAU) in improving cognition. METHODS: For this randomised, open-label, pilot study, we recruited patients aged 19-65 years with euthymic bipolar I disorder from the Mood Disorder Centre in UBC Hospital (Vancouver, Canada)...
February 6, 2017: Lancet Psychiatry
https://www.readbyqxmd.com/read/28161456/moderators-of-mental-health-of-humanitarian-migrants
#6
Chesmal Siriwardhana
No abstract text is available yet for this article.
February 1, 2017: Lancet Psychiatry
https://www.readbyqxmd.com/read/28161455/pre-migration-and-post-migration-factors-associated-with-mental-health-in-humanitarian-migrants-in-australia-and-the-moderation-effect-of-post-migration-stressors-findings-from-the-first-wave-data-of-the-bnla-cohort-study
#7
Wen Chen, Brian J Hall, Li Ling, Andre Mn Renzaho
BACKGROUND: The process of becoming a humanitarian migrant is potentially damaging to mental health. We examined the association between pre-migration and post-migration potentially traumatic events and stressors and mental health, and assessed the moderating effect of post-migration stressors in humanitarian migrants in Australia. METHODS: In this study, we used the first wave of data between 2013 and 2014 from the Building a New Life in Australia survey. The survey included 2399 migrants who had arrived in Australia holding a permanent humanitarian visa 3-6 months preceding the survey, with 77% and 23% of participants being granted visas through offshore and onshore humanitarian programmes, respectively...
February 1, 2017: Lancet Psychiatry
https://www.readbyqxmd.com/read/28159549/the-xxxx-files-mq-swears-in
#8
EDITORIAL
The Lancet Psychiatry
No abstract text is available yet for this article.
January 31, 2017: Lancet Psychiatry
https://www.readbyqxmd.com/read/28153641/how-do-antidepressants-work-new-perspectives-for-refining-future-treatment-approaches
#9
REVIEW
Catherine J Harmer, Ronald S Duman, Philip J Cowen
Most currently available antidepressants target monoamine neurotransmitter function. However, a purely neurotransmitter-based explanation for antidepressant drug action is challenged by the delayed clinical onset of most agents and the need to explain how neurochemical changes reverse the many different symptoms of depression. Novel approaches to understanding of antidepressant drug action include a focus on early changes in emotional and social processing and the role of neural plasticity. In this Review, we discuss the ways in which these two different theories reflect different or complementary approaches, and how they might be integrated to offer novel solutions for people with depression...
January 30, 2017: Lancet Psychiatry
https://www.readbyqxmd.com/read/28109647/post-traumatic-stress-disorder-and-cancer
#10
REVIEW
Matthew J Cordova, Michelle B Riba, David Spiegel
Being diagnosed with and treated for cancer is highly stressful and potentially traumatic. An extensive literature has evaluated the prevalence, predictors, and correlates of cancer-related post-traumatic stress disorder (PTSD) symptoms and diagnoses. In this qualitative review of cancer-related PTSD literature, we highlight conceptual, methodological, and diagnostic issues, and identify clinical implications and areas for future research. Cancer-related PTSD has been documented in a minority of patients with cancer and their family members, is positively associated with other indices of distress and reduced quality of life, and has several correlates and risk factors (eg, prior trauma history, pre-existing psychiatric conditions, poor social support)...
January 18, 2017: Lancet Psychiatry
https://www.readbyqxmd.com/read/28109646/post-traumatic-stress-disorder-and-cardiovascular-disease
#11
REVIEW
Donald Edmondson, Roland von Känel
In this paper, a first in a Series of two, we look at the evidence for an association of post-traumatic stress disorder with incident cardiovascular disease risk and the mechanisms that might cause this association, as well as the prevalence of post-traumatic stress disorder due to cardiovascular disease events and its associated prognostic risk. We discuss research done after the publication of previous relevant systematic reviews, and survey currently funded research from the two most active funders in the field: the National Institutes of Health and the US Veterans Administration...
January 18, 2017: Lancet Psychiatry
https://www.readbyqxmd.com/read/28089312/hunting-down-an-evidence-base-for-adolescent-mental-health
#12
EDITORIAL
The Lancet Psychiatry
No abstract text is available yet for this article.
January 11, 2017: Lancet Psychiatry
https://www.readbyqxmd.com/read/28087200/adolescent-depression-and-the-treatment-gap
#13
Frances Rice, Olga Eyre, Lucy Riglin, Robert Potter
No abstract text is available yet for this article.
January 10, 2017: Lancet Psychiatry
https://www.readbyqxmd.com/read/28089119/not-outsider-artists-just-artists
#14
LETTER
Lizz Brady
No abstract text is available yet for this article.
January 6, 2017: Lancet Psychiatry
https://www.readbyqxmd.com/read/28063879/the-effect-of-vishram-a-grass-roots-community-based-mental-health-programme-on-the-treatment-gap-for-depression-in-rural-communities-in-india-a-population-based-study
#15
Rahul Shidhaye, Vaibhav Murhar, Siddharth Gangale, Luke Aldridge, Rahul Shastri, Rachana Parikh, Ritu Shrivastava, Suvarna Damle, Tasneem Raja, Abhijit Nadkarni, Vikram Patel
BACKGROUND: VISHRAM was a community-based mental health programme with the goal of addressing the mental health risk factors for suicide in people from 30 villages in the Amravati district in Vidarbha, central India. We aimed to assess whether implementation of VISHRAM was associated with an increase in the proportion of people with depression who sought treatment (contact coverage). METHODS: A core strategy of VISHRAM was to increase the demand for care by enhancing mental health literacy and to improve the supply of evidence-based interventions for depression and alcohol-use disorders...
January 4, 2017: Lancet Psychiatry
https://www.readbyqxmd.com/read/28063878/mental-health-services-in-low-income-and-middle-income-countries
#16
K S Jacob
No abstract text is available yet for this article.
January 4, 2017: Lancet Psychiatry
https://www.readbyqxmd.com/read/27979720/neurodevelopmental-disorders
#17
REVIEW
Anita Thapar, Miriam Cooper, Michael Rutter
Neurodevelopmental disorders such as attention deficit hyperactivity disorder (ADHD) and autism spectrum disorder, although most commonly considered in childhood, can be lifelong conditions. In this Personal View that is shaped by clinical experience and research, we adopt a conceptual approach. First, we discuss what disorders are neurodevelopmental and why such a grouping is useful. We conclude that both distinction and grouping are helpful and that it is important to take into account the strong overlap across neurodevelopmental disorders...
December 12, 2016: Lancet Psychiatry
https://www.readbyqxmd.com/read/27914904/from-efficacy-to-pragmatic-trials-does-the-dodo-bird-verdict-apply
#18
Joan Asarnow, Dennis Ougrin
No abstract text is available yet for this article.
November 30, 2016: Lancet Psychiatry
https://www.readbyqxmd.com/read/28137392/sex-and-gender-in-psychiatry
#19
LETTER
Olivia Remes, Louise Lafortune, Kay-Tee Khaw, Carol Brayne
No abstract text is available yet for this article.
February 2017: Lancet Psychiatry
https://www.readbyqxmd.com/read/28137391/how-social-norms-affect-psychiatric-approaches-to-gender-incongruence
#20
LETTER
Reubs Walsh, Lydia Krabbendam
No abstract text is available yet for this article.
February 2017: Lancet Psychiatry
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