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Lancet Psychiatry

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https://www.readbyqxmd.com/read/28259650/can-we-make-cannabis-safer
#1
REVIEW
Amir Englund, Tom P Freeman, Robin M Murray, Philip McGuire
Cannabis use and related problems are on the rise globally alongside an increase in the potency of cannabis sold on both black and legal markets. Additionally, there has been a shift towards abandoning prohibition for a less punitive and more permissive legal stance on cannabis, such as decriminalisation and legalisation. It is therefore crucial that we explore new and innovative ways to reduce harm. Research has found cannabis with high concentrations of its main active ingredient, δ-9-tetrahydrocannabinol (THC), to be more harmful (in terms of causing the main risks associated with cannabis use, such as addiction, psychosis, and cognitive impairment) than cannabis with lower concentrations of THC...
March 1, 2017: Lancet Psychiatry
https://www.readbyqxmd.com/read/28258833/changes-in-substance-use-in-patients-receiving-opioid-substitution-therapy-and-resulting-clinical-challenges-a-17-year-treatment-case-register-analysis
#2
Marcus Herdener, Kenneth M Dürsteler, Erich Seifritz, Carlos Nordt
BACKGROUND: Although the beneficial effects of opioid substitution for the reduction of heroin use are well established, its effect on other substance use is unclear. We aimed to evaluate short-term and long-term changes in substance use in opioid-dependent patients on opioid substitution therapy. We focused on frequent use of heroin, cocaine, benzodiazepines, and alcohol under naturalistic conditions (ie, with non-selected patients and clinical practice as usual) over 17 years. METHODS: This was a treatment case register analysis...
February 28, 2017: Lancet Psychiatry
https://www.readbyqxmd.com/read/28258832/alcohol-problems-need-more-attention-in-patients-receiving-long-term-opioid-substitution-therapy
#3
Wayne D Hall, John Strang
No abstract text is available yet for this article.
February 28, 2017: Lancet Psychiatry
https://www.readbyqxmd.com/read/28238702/changing-the-brain-to-treat-anorexia-nervosa
#4
Carrie J McAdams
No abstract text is available yet for this article.
February 23, 2017: Lancet Psychiatry
https://www.readbyqxmd.com/read/28238701/deep-brain-stimulation-of-the-subcallosal-cingulate-for-treatment-refractory-anorexia-nervosa-1-year-follow-up-of-an-open-label-trial
#5
Nir Lipsman, Eileen Lam, Matthew Volpini, Kalam Sutandar, Richelle Twose, Peter Giacobbe, Devin J Sodums, Gwenn S Smith, D Blake Woodside, Andres M Lozano
BACKGROUND: Anorexia nervosa is a life-threatening illness. Brain circuits believed to drive anorexia nervosa symptoms can be accessed with surgical techniques such as deep brain stimulation (DBS). Initial results suggest that DBS of the subcallosal cingulate is safe and associated with improvements in mood and anxiety. Here, we investigated the safety, clinical, and neuroimaging outcomes of DBS of the subcallosal cingulate in a group of patients during 12 months of active stimulation...
February 23, 2017: Lancet Psychiatry
https://www.readbyqxmd.com/read/28237639/years-of-potential-life-lost-and-life-expectancy-in-schizophrenia-a-systematic-review-and-meta-analysis
#6
Carsten Hjorthøj, Anne Emilie Stürup, John J McGrath, Merete Nordentoft
BACKGROUND: Several studies and meta-analyses have shown that mortality in people with schizophrenia is higher than that in the general population but have used relative measures, such as standardised mortality ratios. We did a systematic review and meta-analysis to estimate years of potential life lost and life expectancy in schizophrenia, which are more direct, absolute measures of increased mortality. METHODS: We searched MEDLINE, PsycINFO, Embase, Cinahl, and Web of Science for published studies on years of potential life lost and life expectancy in schizophrenia...
February 22, 2017: Lancet Psychiatry
https://www.readbyqxmd.com/read/28237638/premature-death-in-schizophrenia-bridging-the-gap
#7
Cherrie Ann Galletly
No abstract text is available yet for this article.
February 22, 2017: Lancet Psychiatry
https://www.readbyqxmd.com/read/28219628/subcortical-brain-volume-differences-in-participants-with-attention-deficit-hyperactivity-disorder-in-children-and-adults-a-cross-sectional-mega-analysis
#8
Martine Hoogman, Janita Bralten, Derrek P Hibar, Maarten Mennes, Marcel P Zwiers, Lizanne S J Schweren, Kimm J E van Hulzen, Sarah E Medland, Elena Shumskaya, Neda Jahanshad, Patrick de Zeeuw, Eszter Szekely, Gustavo Sudre, Thomas Wolfers, Alberdingk M H Onnink, Janneke T Dammers, Jeanette C Mostert, Yolanda Vives-Gilabert, Gregor Kohls, Eileen Oberwelland, Jochen Seitz, Martin Schulte-Rüther, Sara Ambrosino, Alysa E Doyle, Marie F Høvik, Margaretha Dramsdahl, Leanne Tamm, Theo G M van Erp, Anders Dale, Andrew Schork, Annette Conzelmann, Kathrin Zierhut, Ramona Baur, Hazel McCarthy, Yuliya N Yoncheva, Ana Cubillo, Kaylita Chantiluke, Mitul A Mehta, Yannis Paloyelis, Sarah Hohmann, Sarah Baumeister, Ivanei Bramati, Paulo Mattos, Fernanda Tovar-Moll, Pamela Douglas, Tobias Banaschewski, Daniel Brandeis, Jonna Kuntsi, Philip Asherson, Katya Rubia, Clare Kelly, Adriana Di Martino, Michael P Milham, Francisco X Castellanos, Thomas Frodl, Mariam Zentis, Klaus-Peter Lesch, Andreas Reif, Paul Pauli, Terry L Jernigan, Jan Haavik, Kerstin J Plessen, Astri J Lundervold, Kenneth Hugdahl, Larry J Seidman, Joseph Biederman, Nanda Rommelse, Dirk J Heslenfeld, Catharina A Hartman, Pieter J Hoekstra, Jaap Oosterlaan, Georg von Polier, Kerstin Konrad, Oscar Vilarroya, Josep Antoni Ramos-Quiroga, Joan Carles Soliva, Sarah Durston, Jan K Buitelaar, Stephen V Faraone, Philip Shaw, Paul M Thompson, Barbara Franke
BACKGROUND: Neuroimaging studies have shown structural alterations in several brain regions in children and adults with attention deficit hyperactivity disorder (ADHD). Through the formation of the international ENIGMA ADHD Working Group, we aimed to address weaknesses of previous imaging studies and meta-analyses, namely inadequate sample size and methodological heterogeneity. We aimed to investigate whether there are structural differences in children and adults with ADHD compared with those without this diagnosis...
February 16, 2017: Lancet Psychiatry
https://www.readbyqxmd.com/read/28216024/collective-analytics-advancing-the-neuroscience-of-adhd
#9
Claudia Lugo-Candelas, Jonathan Posner
No abstract text is available yet for this article.
February 15, 2017: Lancet Psychiatry
https://www.readbyqxmd.com/read/28219609/neuroscience-in-gambling-policy-and-treatment-an-interdisciplinary-perspective
#10
REVIEW
Murat Yücel, Adrian Carter, Amy R Allen, Bernard Balleine, Luke Clark, Nicki A Dowling, Sally M Gainsbury, Anna E Goudriaan, Jon Grant, Alan Hayes, David Hodgins, Ruth van Holst, Ralph Lattimore, Charles Livingstone, Valentina Lorenzetti, Dan Lubman, Carsten Murawski, Linden Parkes, Nancy Petry, Robin Room, Bruce Singh, Anna Thomas, Phil Townshend, George Youssef, Wayne Hall
Neuroscientific explanations of gambling disorder can help people make sense of their experiences and guide the development of psychosocial interventions. However, the societal perceptions and implications of these explanations are not always clear or helpful. Two workshops in 2013 and 2014 brought together multidisciplinary researchers aiming to improve the clinical and policy-related effects of neuroscience research on gambling. The workshops revealed that neuroscience can be used to improve identification of the dangers of products used in gambling...
February 14, 2017: Lancet Psychiatry
https://www.readbyqxmd.com/read/28185900/evidence-based-science-policy-for-mental-health-in-a-post-truth-era
#11
Harold Alan Pincus, Stephanie A Rolin
No abstract text is available yet for this article.
February 6, 2017: Lancet Psychiatry
https://www.readbyqxmd.com/read/28153641/how-do-antidepressants-work-new-perspectives-for-refining-future-treatment-approaches
#12
REVIEW
Catherine J Harmer, Ronald S Duman, Philip J Cowen
Most currently available antidepressants target monoamine neurotransmitter function. However, a purely neurotransmitter-based explanation for antidepressant drug action is challenged by the delayed clinical onset of most agents and the need to explain how neurochemical changes reverse the many different symptoms of depression. Novel approaches to understanding of antidepressant drug action include a focus on early changes in emotional and social processing and the role of neural plasticity. In this Review, we discuss the ways in which these two different theories reflect different or complementary approaches, and how they might be integrated to offer novel solutions for people with depression...
January 30, 2017: Lancet Psychiatry
https://www.readbyqxmd.com/read/28109647/post-traumatic-stress-disorder-and-cancer
#13
REVIEW
Matthew J Cordova, Michelle B Riba, David Spiegel
Being diagnosed with and treated for cancer is highly stressful and potentially traumatic. An extensive literature has evaluated the prevalence, predictors, and correlates of cancer-related post-traumatic stress disorder (PTSD) symptoms and diagnoses. In this qualitative review of cancer-related PTSD literature, we highlight conceptual, methodological, and diagnostic issues, and identify clinical implications and areas for future research. Cancer-related PTSD has been documented in a minority of patients with cancer and their family members, is positively associated with other indices of distress and reduced quality of life, and has several correlates and risk factors (eg, prior trauma history, pre-existing psychiatric conditions, poor social support)...
January 18, 2017: Lancet Psychiatry
https://www.readbyqxmd.com/read/28109646/post-traumatic-stress-disorder-and-cardiovascular-disease
#14
REVIEW
Donald Edmondson, Roland von Känel
In this paper, a first in a Series of two, we look at the evidence for an association of post-traumatic stress disorder with incident cardiovascular disease risk and the mechanisms that might cause this association, as well as the prevalence of post-traumatic stress disorder due to cardiovascular disease events and its associated prognostic risk. We discuss research done after the publication of previous relevant systematic reviews, and survey currently funded research from the two most active funders in the field: the National Institutes of Health and the US Veterans Administration...
January 18, 2017: Lancet Psychiatry
https://www.readbyqxmd.com/read/28089312/hunting-down-an-evidence-base-for-adolescent-mental-health
#15
EDITORIAL
The Lancet Psychiatry
No abstract text is available yet for this article.
January 11, 2017: Lancet Psychiatry
https://www.readbyqxmd.com/read/28087200/adolescent-depression-and-the-treatment-gap
#16
Frances Rice, Olga Eyre, Lucy Riglin, Robert Potter
No abstract text is available yet for this article.
January 10, 2017: Lancet Psychiatry
https://www.readbyqxmd.com/read/28089119/not-outsider-artists-just-artists
#17
LETTER
Lizz Brady
No abstract text is available yet for this article.
January 6, 2017: Lancet Psychiatry
https://www.readbyqxmd.com/read/28063879/the-effect-of-vishram-a-grass-roots-community-based-mental-health-programme-on-the-treatment-gap-for-depression-in-rural-communities-in-india-a-population-based-study
#18
Rahul Shidhaye, Vaibhav Murhar, Siddharth Gangale, Luke Aldridge, Rahul Shastri, Rachana Parikh, Ritu Shrivastava, Suvarna Damle, Tasneem Raja, Abhijit Nadkarni, Vikram Patel
BACKGROUND: VISHRAM was a community-based mental health programme with the goal of addressing the mental health risk factors for suicide in people from 30 villages in the Amravati district in Vidarbha, central India. We aimed to assess whether implementation of VISHRAM was associated with an increase in the proportion of people with depression who sought treatment (contact coverage). METHODS: A core strategy of VISHRAM was to increase the demand for care by enhancing mental health literacy and to improve the supply of evidence-based interventions for depression and alcohol-use disorders...
January 4, 2017: Lancet Psychiatry
https://www.readbyqxmd.com/read/28063878/mental-health-services-in-low-income-and-middle-income-countries
#19
K S Jacob
No abstract text is available yet for this article.
January 4, 2017: Lancet Psychiatry
https://www.readbyqxmd.com/read/28236959/apec-digital-hub-for-mental-health
#20
LETTER
Chee Ng, Maureen Goodenow, Andrew Greenshaw, Phil Upshall, Raymond Lam
No abstract text is available yet for this article.
March 2017: Lancet Psychiatry
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