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Lancet Psychiatry

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https://www.readbyqxmd.com/read/28454915/brain-microglia-in-psychiatric-disorders
#1
REVIEW
Valeria Mondelli, Anthony C Vernon, Federico Turkheimer, Paola Dazzan, Carmine M Pariante
The role of immune activation in psychiatric disorders has attracted considerable attention over the past two decades, contributing to the rise of a new era for psychiatry. Microglia, the macrophages of the brain, are progressively becoming the main focus of the research in this field. In this Review, we assess the literature on microglia activation across different psychiatric disorders, including post-mortem and in-vivo studies in humans and experimental studies in animals. Although microglia activation has been noted in all types of psychiatric disorder, no association was seen with specific diagnostic categories...
April 25, 2017: Lancet Psychiatry
https://www.readbyqxmd.com/read/28434872/the-use-of-emergency-department-based-psychological-interventions-to-reduce-repetition-of-self-harm-behaviour
#2
Katrina Witt
No abstract text is available yet for this article.
April 20, 2017: Lancet Psychiatry
https://www.readbyqxmd.com/read/28434871/a-brief-psychological-intervention-to-reduce-repetition-of-self-harm-in-patients-admitted-to-hospital-following-a-suicide-attempt-a-randomised-controlled-trial
#3
Rory C O'Connor, Eamonn Ferguson, Fiona Scott, Roger Smyth, David McDaid, A-La Park, Annette Beautrais, Christopher J Armitage
BACKGROUND: We investigated whether a volitional helpsheet (VHS), a brief psychological intervention, could reduce repeat self-harm in the 6 months following a suicide attempt. METHODS: We did a prospective, single-site, randomised controlled trial. Patients admitted to a hospital in Edinburgh, UK, after a suicide attempt were deemed eligible for the study if they were over the age of 16 years, had a self-reported history of self-harm, were fluent in English, were medically fit to interview, and were not participating in other research studies within the hospital...
April 20, 2017: Lancet Psychiatry
https://www.readbyqxmd.com/read/28433615/digital-technology-for-treating-and-preventing-mental-disorders-in-low-income-and-middle-income-countries-a-narrative-review-of-the-literature
#4
REVIEW
John A Naslund, Kelly A Aschbrenner, Ricardo Araya, Lisa A Marsch, Jürgen Unützer, Vikram Patel, Stephen J Bartels
Few individuals living with mental disorders around the globe have access to mental health care, yet most have access to a mobile phone. Digital technology holds promise for improving access to, and quality of, mental health care. We reviewed evidence on the use of mobile, online, and other remote technologies for treatment and prevention of mental disorders in low-income and middle-income countries. Of the 49 studies identified, most were preliminary evaluations of feasibility and acceptability. The findings were promising, showing the potential effectiveness of online, text-messaging, and telephone support interventions...
April 19, 2017: Lancet Psychiatry
https://www.readbyqxmd.com/read/28408194/low-dose-imipramine-for-multiple-functional-somatic-syndromes
#5
Andrew Moore, Dominic Aldington
No abstract text is available yet for this article.
April 10, 2017: Lancet Psychiatry
https://www.readbyqxmd.com/read/28408193/imipramine-versus-placebo-for-multiple-functional-somatic-syndromes-stress-3-a-double-blind-randomised-study
#6
Johanne L Agger, Andreas Schröder, Lise K Gormsen, Jens S Jensen, Troels S Jensen, Per K Fink
BACKGROUND: Functional somatic syndromes, including chronic fatigue syndrome or irritable bowel syndrome, often co-exist. Treatment guidelines supported by high quality evidence exist for most functional somatic syndromes, but are lacking for multiple comorbid functional somatic syndromes. We aimed to assess the effect of the tricyclic antidepressant, imipramine, in patients with multiple functional somatic syndromes defined by the criteria for multiorgan bodily distress syndrome, a unifying diagnosis that encompasses most functional somatic syndromes and somatoform disorders...
April 10, 2017: Lancet Psychiatry
https://www.readbyqxmd.com/read/28396067/control-conditions-for-randomised-trials-of-behavioural-interventions-in-psychiatry-a-decision-framework
#7
REVIEW
Stefan M Gold, Paul Enck, Helge Hasselmann, Tim Friede, Ulrich Hegerl, David C Mohr, Christian Otte
In psychiatry, comparative analyses of therapeutic options and the aggregation of data from clinical trials across different therapeutic approaches play an important role in clinical decision making, treatment guidelines, and health policy. This approach assumes that trials of pharmacological and behavioural therapies generally produce the same level of evidence when properly designed. However, trial design for behavioural interventions has some unique characteristics and control groups vary widely, which influence the effects observed in any given trial...
April 7, 2017: Lancet Psychiatry
https://www.readbyqxmd.com/read/28395988/ketamine-treatment-for-depression-opportunities-for-clinical-innovation-and-ethical-foresight
#8
REVIEW
Ilina Singh, Celia Morgan, Valerie Curran, David Nutt, Anne Schlag, Rupert McShane
We present a review and analysis of the ethical considerations in off-label ketamine use for severe, treatment-resistant depression. The analysis of ethical considerations is contextualised in an overview of the evidence for ketamine use in depression, and a review of the drug's safety profile. We find that, based on current evidence, ketamine use for severe, treatment-resistant depression does not violate ethical principles; however, clinicians and professional bodies must take steps to ensure that guidelines for good practice are enacted, that all experimental and trial data are made available through national registries, and that the risk potential of ketamine treatment continues to be monitored and modelled...
April 5, 2017: Lancet Psychiatry
https://www.readbyqxmd.com/read/28395987/the-practicalities-and-ethics-of-ketamine-for-depression
#9
Christopher James Ryan, Colleen Loo
No abstract text is available yet for this article.
April 5, 2017: Lancet Psychiatry
https://www.readbyqxmd.com/read/28365133/in-search-of-insane-places
#10
LETTER
Susannah Cahalan
No abstract text is available yet for this article.
March 29, 2017: Lancet Psychiatry
https://www.readbyqxmd.com/read/28359864/reduction-in-adolescent-depression-after-contact-with-mental-health-services-a-longitudinal-cohort-study-in-the-uk
#11
LETTER
Sharon A S Neufeld, Peter B Jones, Ian M Goodyer
No abstract text is available yet for this article.
March 27, 2017: Lancet Psychiatry
https://www.readbyqxmd.com/read/28359863/ketamine-and-ect-better-alone-than-together
#12
Charles H Kellner, Dan V Iosifescu
No abstract text is available yet for this article.
March 27, 2017: Lancet Psychiatry
https://www.readbyqxmd.com/read/28359862/ketamine-augmentation-of-electroconvulsive-therapy-to-improve-neuropsychological-and-clinical-outcomes-in-depression-ketamine-ect-a-multicentre-double-blind-randomised-parallel-group-superiority-trial
#13
Ian M Anderson, Andrew Blamire, Tim Branton, Ross Clark, Darragh Downey, Graham Dunn, Andrew Easton, Rebecca Elliott, Clare Elwell, Katherine Hayden, Fiona Holland, Salman Karim, Colleen Loo, Jo Lowe, Rajesh Nair, Timothy Oakley, Antony Prakash, Parveen K Sharma, Stephen R Williams, R Hamish McAllister-Williams
BACKGROUND: The use of electroconvulsive therapy (ECT) is limited by concerns about its cognitive adverse effects. Preliminary evidence suggests that administering the glutamate antagonist ketamine with ECT might alleviate cognitive adverse effects and accelerate symptomatic improvement; we tested this in a randomised trial of low-dose ketamine. METHODS: In this multicentre, randomised, parallel-group study in 11 ECT suites serving inpatient and outpatient care settings in seven National Health Service trusts in the North of England, we recruited severely depressed patients, who were diagnosed as having unipolar or bipolar depressive episodes defined as moderate or severe by DSM-IV criteria, aged at least 18 years, and were able and willing to provide written consent to participate in the study...
March 27, 2017: Lancet Psychiatry
https://www.readbyqxmd.com/read/28359861/corrections
#14
(no author information available yet)
No abstract text is available yet for this article.
March 27, 2017: Lancet Psychiatry
https://www.readbyqxmd.com/read/28344044/impairments-of-motor-function-among-children-with-a-familial-risk-of-schizophrenia-or-bipolar-disorder-at-7-years-old-in-denmark-an-observational-cohort-study
#15
Birgitte Klee Burton, Anne A E Thorup, Jens Richardt Jepsen, Gry Poulsen, Ditte Ellersgaard, Katrine S Spang, Camilla Jerlang Christiani, Nicoline Hemager, Ditte Gantriis, Aja Greve, Ole Mors, Merete Nordentoft, Kerstin Jessica Plessen
BACKGROUND: Owing to the genetic overlap between schizophrenia and bipolar disorder, we aimed to assess domain-specific motor aberrations and disorder specificity among 7-year-old children with a familial risk of schizophrenia or bipolar disorder by comparing children in familial risk groups with each other and with children not in these risk groups. METHODS: In the Danish High Risk and Resilience Study, we established a cohort of 7-year-old children with no, one, or two parents with schizophrenia or bipolar disorder in Denmark between Jan 1, 2013, and Jan 31, 2016...
March 23, 2017: Lancet Psychiatry
https://www.readbyqxmd.com/read/28344043/renewed-awareness-of-motor-symptoms-in-psychiatric-assessment
#16
Anne Beate Helseth Udal
No abstract text is available yet for this article.
March 23, 2017: Lancet Psychiatry
https://www.readbyqxmd.com/read/28330590/ego-id-and-ireland
#17
Brendan D Kelly
No abstract text is available yet for this article.
March 16, 2017: Lancet Psychiatry
https://www.readbyqxmd.com/read/28330589/ethnicity-and-excess-mortality-in-severe-mental-illness-a-cohort-study
#18
Jayati Das-Munshi, Chin-Kuo Chang, Rina Dutta, Craig Morgan, James Nazroo, Robert Stewart, Martin J Prince
BACKGROUND: Excess mortality in severe mental illness (defined here as schizophrenia, schizoaffective disorders, and bipolar affective disorders) is well described, but little is known about this inequality in ethnic minorities. We aimed to estimate excess mortality for people with severe mental illness for five ethnic groups (white British, black Caribbean, black African, south Asian, and Irish) and to assess the association of ethnicity with mortality risk. METHODS: We conducted a longitudinal cohort study of individuals with a valid diagnosis of severe mental illness between Jan 1, 2007, and Dec 31, 2014, from the case registry of the South London and Maudsley Trust (London, UK)...
March 16, 2017: Lancet Psychiatry
https://www.readbyqxmd.com/read/28330588/why-serious-mental-illness-should-be-designated-a-health-disparity-and-the-paradox-of-ethnicity
#19
Stephen J Bartels, Peter DiMilia
No abstract text is available yet for this article.
March 16, 2017: Lancet Psychiatry
https://www.readbyqxmd.com/read/28259650/can-we-make-cannabis-safer
#20
REVIEW
Amir Englund, Tom P Freeman, Robin M Murray, Philip McGuire
Cannabis use and related problems are on the rise globally alongside an increase in the potency of cannabis sold on both black and legal markets. Additionally, there has been a shift towards abandoning prohibition for a less punitive and more permissive legal stance on cannabis, such as decriminalisation and legalisation. It is therefore crucial that we explore new and innovative ways to reduce harm. Research has found cannabis with high concentrations of its main active ingredient, δ-9-tetrahydrocannabinol (THC), to be more harmful (in terms of causing the main risks associated with cannabis use, such as addiction, psychosis, and cognitive impairment) than cannabis with lower concentrations of THC...
March 1, 2017: Lancet Psychiatry
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