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Oncoscience

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https://www.readbyqxmd.com/read/28105458/brg1-and-brm-loss-selectively-impacts-rb-and-p53-respectively-brg1-and-brm-have-differential-functions-in-vivo
#1
Stefanie B Marquez-Vilendrer, Sudhir K Rai, Sarah Jb Gramling, Li Lu, David N Reisman
The SWI/SNF complex is an important regulator of gene expression that functions by interacting with a diverse array of cellular proteins. The catalytic subunits of SWI/SNF, BRG1 and BRM, are frequently lost alone or concomitantly in a range of different cancer types. This loss abrogates SWI/SNF complex function as well as the functions of proteins that are required for SWI/SNF function, such as RB1 and TP53. Yet while both proteins are known to be dependent on SWI/SNF, we found that BRG1, but not BRM, is functionally linked to RB1, such that loss of BRG1 can directly or indirectly inactivate the RB1 pathway...
2016: Oncoscience
https://www.readbyqxmd.com/read/28105457/loss-of-the-swi-snf-atpase-subunits-brm-and-brg1-drives-lung-cancer-development
#2
Stefanie B Marquez-Vilendrer, Sudhir K Rai, Sarah Jb Gramling, Li Lu, David N Reisman
Inactivation of Brg1 and Brm accelerated lung tumor development, shortened tumor latency, and caused a loss of differentiation. Tumors with Brg1 and/or Brm loss recapitulated the evolution of human lung cancer as observed by the development of local tumor invasion as well as distal tumor metastasis, thereby making this model useful in lung cancer studies. Brg1 loss contributed to metastasis in part by driving E-cadherin loss and Vimentin up-regulation. By changing more than 6% of the murine genome with the down-regulation of tumor suppressors, DNA repair, differentiation and cell adhesion genes, and the concomitant up-regulation of oncogenes, angiogenesis, metastasis and antiapoptosis genes, caused by the dual loss of Brg1/Brm further accelerated tumor development...
2016: Oncoscience
https://www.readbyqxmd.com/read/28105456/cd44-a-metastasis-driver-and-therapeutic-target
#3
EDITORIAL
Joseph L Sottnik, Dan Theodorescu
No abstract text is available yet for this article.
2016: Oncoscience
https://www.readbyqxmd.com/read/28105455/mutation-hotspots-in-cis-regulatory-regions-in-cancer
#4
EDITORIAL
Rebecca C Poulos, Jason W H Wong
No abstract text is available yet for this article.
2016: Oncoscience
https://www.readbyqxmd.com/read/28105454/bet-bromodomain-inhibitor-jq1-and-tumor-angiogenesis
#5
EDITORIAL
Hemant Kumar Bid, Samuel Kerk
No abstract text is available yet for this article.
2016: Oncoscience
https://www.readbyqxmd.com/read/28105453/eradication-of-cml-stem-cells
#6
EDITORIAL
Bing Z Carter, Michael Andreeff
No abstract text is available yet for this article.
2016: Oncoscience
https://www.readbyqxmd.com/read/28105452/genetic-biomarkers-for-pd-1-pd-l1-blockade-therapy
#7
EDITORIAL
Keisuke Kataoka, Seishi Ogawa
No abstract text is available yet for this article.
2016: Oncoscience
https://www.readbyqxmd.com/read/28105451/a-mirna-signature-assessing-ovarian-cancer-prognosis
#8
EDITORIAL
Marina Bagnoli, Sandro Pignata, Delia Mezzanzanica
No abstract text is available yet for this article.
2016: Oncoscience
https://www.readbyqxmd.com/read/28105450/targeting-bip-to-induce-endoplasmic-reticulum-stress-and-cancer-cell-death
#9
EDITORIAL
Michaël Cerezo, Rachid Benhida, Stéphane Rocchi
No abstract text is available yet for this article.
2016: Oncoscience
https://www.readbyqxmd.com/read/28105449/breast-conserving-therapy-versus-mastectomy
#10
EDITORIAL
Marissa C van Maaren, Philip Poortmans, Sabine Siesling
No abstract text is available yet for this article.
2016: Oncoscience
https://www.readbyqxmd.com/read/28105448/adaptive-survival-mechanism-to-glucose-restrictions
#11
EDITORIAL
Nabil Djouder
No abstract text is available yet for this article.
2016: Oncoscience
https://www.readbyqxmd.com/read/28105447/gene-enhancer-deregulation-and-epigenetic-vulnerability
#12
EDITORIAL
Rui Lu, Gang Greg Wang
No abstract text is available yet for this article.
2016: Oncoscience
https://www.readbyqxmd.com/read/28105446/bevacizumab-in-her2-negative-inflammatory-breast-cancer
#13
EDITORIAL
François Bertucci, Anthony Goncalves, Patrice Viens
No abstract text is available yet for this article.
2016: Oncoscience
https://www.readbyqxmd.com/read/28050579/oncogenic-mechanisms-of-hoxb13-missense-mutations-in-prostate-carcinogenesis
#14
Marta Cardoso, Sofia Maia, Paula Paulo, Manuel R Teixeira
The recurrent germline mutation HOXB13 p.(Gly84Glu) (G84E) has recently been identified as a risk factor for prostate cancer. In a recent study, we have performed full sequencing of the HOXB13 gene in 462 Portuguese prostate cancer patients with early-onset and/or familial/hereditary disease, and identified two novel missense mutations, p.(Ala128Asp) (A128D) and p.(Phe240Leu) (F240L), that were predicted to be damaging to protein function. In the present work we aimed to investigate the potential oncogenic role of these mutations, comparing to that of the recurrent G84E mutation and wild-type HOXB13...
2016: Oncoscience
https://www.readbyqxmd.com/read/28050578/high-frequency-ultrasound-detection-of-cell-death-spectral-differentiation-of-different-forms-of-cell-death-in-vitro
#15
Maurice M Pasternak, Ali Sadeghi-Naini, Shawn M Ranieri, Anoja Giles, Michael L Oelze, Michael C Kolios, Gregory J Czarnota
High frequency quantitative ultrasound techniques were investigated to characterize different forms of cell death in vitro. Suspension-grown acute myeloid leukemia cells were treated to cause apoptosis, oncosis, mitotic arrest, and heat-induced death. Samples were scanned with 20 and 40 MHz ultrasound and assessed histologically in terms of cellular structure. Frequency-domain analysis of 20 MHz ultrasound data demonstrated midband fit changes of 6.0 ± 0.7 dBr, 6.2 ± 1.8 dBr, 4.0 ± 1.0 dBr and -4.6 ± 1...
2016: Oncoscience
https://www.readbyqxmd.com/read/28050577/the-importance-of-tissue-confirmation-of-metastatic-disease-in-patients-with-breast-cancer-lesson-from-a-brain-metastasis-case
#16
Jingxian Ding, Pinghua Hu, Jun Chen, Xiaobo Wu, Yali Cao
BACKGROUND: The discrepancy of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2) statuses in breast cancers has been reported. Available systemic therapy for patients with breast cancer is based on the molecular subtypes as identified by IHC and/or FISH. However, these biomarkers may change throughout tumor progression. CASE PRESENTATION: We report a relatively uncommon case of a 39-year-old Chinese woman with local advanced breast cancer (LABC) treated with 6 cycles of docetaxel, doxorubicin and cyclophosphamide (TAC) regimen neoadjuvant chemotherapy, and subsequently mastectomy, intensity-modulated radiation therapy (IMRT) and tamoxifen followed as regularly...
2016: Oncoscience
https://www.readbyqxmd.com/read/28050576/the-epichaperome-the-power-of-many-as-the-power-of-one
#17
EDITORIAL
Wang Tai, Monica L Guzman, Gabriela Chiosis
No abstract text is available yet for this article.
2016: Oncoscience
https://www.readbyqxmd.com/read/27713914/atrx-idh1-r132h-and-ki-67-immunohistochemistry-as-a-classification-scheme-for-astrocytic-tumors
#18
Jinquan Cai, Chuanbao Zhang, Wei Zhang, Guangzhi Wang, Kun Yao, Zhiliang Wang, Guanzhang Li, Zenghui Qian, Yongli Li, Tao Jiang, Chuanlu Jiang
Recurrence and progression to higher grade lesions are key biological events and characteristic behaviors in the evolution process of glioma. Malignant astrocytic tumors such as glioblastoma (GBM) are the most lethal intracranial tumors. However, the clinical practicability and significance of molecular parameters for the diagnostic and prognostic prediction of astrocytic tumors is still limited. In this study, we detected ATRX, IDH1-R132H and Ki-67 by immunohistochemistry and observed the association of IDH1-R132H with ATRX and Ki-67 expression...
2016: Oncoscience
https://www.readbyqxmd.com/read/27713913/the-metastasis-inducer-ccn1-cyr61-activates-the-fatty-acid-synthase-fasn-driven-lipogenic-phenotype-in-breast-cancer-cells
#19
Javier A Menendez, Luciano Vellon, Ingrid Espinoza, Ruth Lupu
The angiogenic inducer CCN1 (Cysteine-rich 61, CYR61) is differentially activated in metastatic breast carcinomas. However, little is known about the precise mechanisms that underlie the pro-metastatic actions of CCN1. Here, we investigated the impact of CCN1 expression on fatty acid synthase (FASN), a metabolic oncogene thought to provide cancer cells with proliferative and survival advantages. Forced expression of CCN1 in MCF-7 cells robustly up-regulated FASN protein expression and also significantly increased FASN gene promoter activity 2- to 3-fold, whereas deletion of the sterol response element-binding protein (SREBP) binding site in the FASN promoter completely abrogated CCN1-driven transcriptional activation...
2016: Oncoscience
https://www.readbyqxmd.com/read/27713912/targeted-proteomic-approach-in-prostatic-tissue-a-panel-of-potential-biomarkers-for-cancer-detection
#20
Donatella Aiello, Francesca Casadonte, Rosa Terracciano, Rocco Damiano, Rocco Savino, Giovanni Sindona, Anna Napoli
Prostate cancer (PCa) is the sixth highest causes of cancer-related deaths in men. The molecular events underlying its behavior and evolution are not completely understood. Prostate-specific antigen (PSA) is the only approved Food and Drug Administration biomarker. A panel of ten stage-specific tumoral and adjacent non tumoral tissues from patients affected by PCa (Gleason score 6, 3+3; PSA 10 ÷19 ng/ml) was investigated by MS-based proteomics approach. The proposed method was based on identifying the base-soluble proteins from tissue, established an efficient study, which lead to a deeper molecular perspective understanding of the PCa...
2016: Oncoscience
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