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Oncoscience

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https://www.readbyqxmd.com/read/29854879/non-selective-beta-blockers-inhibit-angiosarcoma-cell-viability-and-increase-progression-free-and-overall-survival-in-patients-diagnosed-with-metastatic-angiosarcoma
#1
Clarissa N Amaya, Mariah Perkins, Andres Belmont, Connie Herrera, Arezo Nasrazadani, Alejandro Vargas, Thuraieh Khayou, Alexa Montoya, Yessenia Ballou, Dana Galvan, Alexandria Rivas, Steven Rains, Luv Patel, Vanessa Ortega, Christopher Lopez, William Chow, Erin B Dickerson, Brad A Bryan
Patients with metastatic angiosarcoma undergoing chemotherapy, radiation, and/or surgery experience a median progression free survival of less than 6 months and a median overall survival of less than 12 months. Given the aggressive nature of this cancer, angiosarcoma clinical responses to chemotherapy or targeted therapeutics are generally very poor. Inhibition of beta adrenergic receptor (β-AR) signaling has recently been shown to decrease angiosarcoma tumor cell viability, abrogate tumor growth in mouse models, and decrease proliferation rates in preclinical and clinical settings...
March 2018: Oncoscience
https://www.readbyqxmd.com/read/29854878/panobinostat-suppresses-the-mesenchymal-phenotype-in-a-novel-claudin-low-triple-negative-patient-derived-breast-cancer-model
#2
Margarite D Matossian, Hope E Burks, Steven Elliott, Van T Hoang, Annie C Bowles, Rachel A Sabol, Bruce A Bunnell, Elizabeth C Martin, Matthew E Burow, Bridgette M Collins-Burow
Claudin-low triple negative breast cancer (CL-TNBC) is a clinically aggressive molecular TNBC subtype characterized by a propensity to metastasize, recur and acquire chemoresistance. CL-TNBC has a diverse intra- and extracellular composition and microenvironment, and currently there are no clinically approved targeted therapies. Histone deacetylase inhibitors (HDACi) have been investigated as therapeutic agents targeting invasive TNBC phenotypes. However, further studies are required to evaluate HDAC inhibition in CL-TNBC...
March 2018: Oncoscience
https://www.readbyqxmd.com/read/29854877/a-novel-isolation-method-for-cancer-prognostic-factors-via-the-p53-pathway-by-a-combination-of-in-vitro-and-in-silico-analyses
#3
Yohey Kamijo, Kohichi Kawahara, Takuma Yoshinaga, Hiroyuki Kurata, Kazunari Arima, Tatsuhiko Furukawa
Identifying new therapeutic target genes affecting the survival of patients with cancer is crucial for the development of new cancer therapies. Here, we developed a novel technology combining in vitro short hairpin RNA (shRNA) library screening and in silico analysis of the tumor transcriptome to identify prognostic factors via the p53 tumor-suppressor pathway. For initial screening, we screened 5,000 genes through selection of shRNAs in p53 wild-type tumor cells that altered sensitivity to the p53 activator actinomycin D (ActD) to identify p53 regulatory genes; shRNAs targeting 322 genes were obtained...
March 2018: Oncoscience
https://www.readbyqxmd.com/read/29854876/plasma-derived-exosomes-reverse-epithelial-to-mesenchymal-transition-after-photodynamic-therapy-of-patients-with-head-and-neck-cancer
#4
Marie-Nicole Theodoraki, Saigopalakrishna S Yerneni, Cornelia Brunner, Joannis Theodorakis, Thomas K Hoffmann, Theresa L Whiteside
Photodynamic therapy (PDT) is a palliative treatment option for head and neck squamous cell carcinoma (HNSCC) patients which induces local inflammation and alters tumor cell morphology. We show that exosomes in plasma of HNSCC patients undergoing PDT reprogram tumor cells towards an epithelial phenotype. Nine HNSCC patients were treated with PDT and plasma was collected prior to and at three timepoints after therapy. Exosome levels of E-Cadherin, N-Cadherin and TGF-β1 were tested by flow cytometry. Exosomes were co-incubated with cancer cells, and changes in expression of EMT markers were evaluated as were proliferation, migration, chemotaxis and invasiveness of tumor cells...
March 2018: Oncoscience
https://www.readbyqxmd.com/read/29854875/selective-targeting-of-p53-gain-of-function-mutants-in-cancer
#5
EDITORIAL
Achuth Padmanabhan
No abstract text is available yet for this article.
March 2018: Oncoscience
https://www.readbyqxmd.com/read/29854874/mitochondrial-genetics-new-model-uncovering-roles-in-tumorigenicity-and-metastasis
#6
EDITORIAL
Thomas C Beadnell, Danny R Welch
No abstract text is available yet for this article.
March 2018: Oncoscience
https://www.readbyqxmd.com/read/29854873/programming-a-serial-killer-car-t-cells-form-non-classical-immune-synapses
#7
EDITORIAL
Alexander J Davenport, Misty R Jenkins
No abstract text is available yet for this article.
March 2018: Oncoscience
https://www.readbyqxmd.com/read/29854872/hedgehog-in-prostate-cancer-explained
#8
EDITORIAL
Ralph Buttyan, Na Li, Shabnam Massah
No abstract text is available yet for this article.
March 2018: Oncoscience
https://www.readbyqxmd.com/read/29854871/cd39-as-a-marker-of-pathogenic-cd8-t-cells-in-cancer-and-other-chronic-inflammatory-diseases
#9
EDITORIAL
Fernando Pablo Canale, María Cecilia Ramello, Carolina Lucía Montes
No abstract text is available yet for this article.
March 2018: Oncoscience
https://www.readbyqxmd.com/read/29854870/germline-genetic-testing-in-prostate-cancer-further-enrichment-in-variant-histologies
#10
EDITORIAL
Mark C Markowski, Emmanuel S Antonarakis
No abstract text is available yet for this article.
March 2018: Oncoscience
https://www.readbyqxmd.com/read/29854869/bfl-1-expression-determines-the-efficacy-of-venetoclax-in-myc-bcl2-double-hit-lymphoma
#11
EDITORIAL
Anna Esteve-Arenys, Gael Roue
No abstract text is available yet for this article.
March 2018: Oncoscience
https://www.readbyqxmd.com/read/29854868/targeting-parallel-bypass-signaling-to-combat-adaptive-resistance-to-braf-inhibition-in-colorectal-cancer
#12
EDITORIAL
Chenxi Gao, Jing Hu
No abstract text is available yet for this article.
March 2018: Oncoscience
https://www.readbyqxmd.com/read/29854867/vegf-signaling-in-acute-leukemia-mitochondrial-connections
#13
EDITORIAL
Sandrina Nóbrega-Pereira, Sérgio Dias
No abstract text is available yet for this article.
March 2018: Oncoscience
https://www.readbyqxmd.com/read/29854866/combination-drug-development-in-braf-mutant-colorectal-cancer
#14
EDITORIAL
Michael Lam, Shubham Pant, Timothy A Yap
No abstract text is available yet for this article.
March 2018: Oncoscience
https://www.readbyqxmd.com/read/29854865/the-hippo-pathway-and-cancer-immunity-friend-or-foe
#15
EDITORIAL
Helena J Janse van Rensburg, Xiaolong Yang
No abstract text is available yet for this article.
March 2018: Oncoscience
https://www.readbyqxmd.com/read/29556516/high-dimensional-regression-analysis-links-magnetic-resonance-imaging-features-and-protein-expression-and-signaling-pathway-alterations-in-breast-invasive-carcinoma
#16
Michael Lehrer, Anindya Bhadra, Sathvik Aithala, Visweswaran Ravikumar, Youyun Zheng, Basak Dogan, Emerlinda Bonaccio, Elizabeth S Burnside, Elizabeth Morris, Elizabeth Sutton, Gary J Whitman, Jose Net, Kathy Brandt, Marie Ganott, Margarita Zuley, Arvind Rao
Background: Imaging features derived from MRI scans can be used for not only breast cancer detection and measuring disease extent, but can also determine gene expression and patient outcomes. The relationships between imaging features, gene/protein expression, and response to therapy hold potential to guide personalized medicine. We aim to characterize the relationship between radiologist-annotated tumor phenotypic features (based on MRI) and the underlying biological processes (based on proteomic profiling) in the tumor...
January 2018: Oncoscience
https://www.readbyqxmd.com/read/29556515/targeting-focal-adhesion-kinase-overcomes-erlotinib-resistance-in-smoke-induced-lung-cancer-by-altering-phosphorylation-of-epidermal-growth-factor-receptor
#17
Hitendra S Solanki, Remya Raja, Alex Zhavoronkov, Ivan V Ozerov, Artem V Artemov, Jayshree Advani, Aneesha Radhakrishnan, Niraj Babu, Vinuth N Puttamallesh, Nazia Syed, Vishalakshi Nanjappa, Tejaswini Subbannayya, Nandini A Sahasrabuddhe, Arun H Patil, T S Keshava Prasad, Daria Gaykalova, Xiaofei Chang, Rachana Sathyendran, Premendu Prakash Mathur, Annapoorni Rangarajan, David Sidransky, Akhilesh Pandey, Evgeny Izumchenko, Harsha Gowda, Aditi Chatterjee
EGFR-based targeted therapies have shown limited success in smokers. Identification of alternate signaling mechanism(s) leading to TKI resistance in smokers is critically important. We observed increased resistance to erlotinib in H358 NSCLC (non-small cell lung carcinoma) cells chronically exposed to cigarette smoke (H358-S) compared to parental cells. SILAC-based mass-spectrometry approach was used to study altered signaling in H358-S cell line. Importantly, among the top phosphosites in H358-S cells we observed hyperphosphorylation of EGFR (Y1197) and non-receptor tyrosine kinase FAK (Y576/577)...
January 2018: Oncoscience
https://www.readbyqxmd.com/read/29556514/determinant-factors-for-chronic-kidney-disease-after-partial-nephrectomy
#18
REVIEW
Oscar D Martín, Heilen Bravo, Marcos Arias, Diego Dallos, Yesica Quiroz, Luis G Medina, Giovanni E Cacciamani, Raul G Carlini
The objective of this review is to evaluate the factors that determine the development or deterioration of Chronic Kidney Disease (CKD) after partial nephrectomy (PN). When current literature is reviewed, it is found that factors that influence renal function after partial nephrectomy, are multifactorial. Those are divided into pre-surgical factors, such as hypertension, diabetes mellitus, urolithiasis, obesity, metabolic syndrome among others; intra-surgical factors, like the surgical technique used, the remaining healthy tissue, the experience of the surgeon, the time and type of ischemia among others...
January 2018: Oncoscience
https://www.readbyqxmd.com/read/29556513/re-thinking-the-preclinical-development-of-gbm-therapeutics
#19
EDITORIAL
Érika Cosset, Sara M Weis, David A Cheresh
No abstract text is available yet for this article.
January 2018: Oncoscience
https://www.readbyqxmd.com/read/29556512/in-quest-for-leukemia-initiating-cells-in-aml
#20
EDITORIAL
Maria De Grandis, Stéphane Jc Mancini, Michel Aurrand-Lions
No abstract text is available yet for this article.
January 2018: Oncoscience
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