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Oncoscience

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https://www.readbyqxmd.com/read/29142905/p-cadherin-cdh3-is-overexpressed-in-colorectal-tumors-and-has-potential-as-a-serum-marker-for-colorectal-cancer-monitoring
#1
H M C Shantha Kumara, Geoffrey A Bellini, Otavia L Caballero, Sonali A C Herath, Tao Su, Aqeel Ahmed, Linda Njoh, Vesna Cekic, Richard L Whelan
Introduction: Placental-Cadherin (CDH3) is a cell adhesion molecule vital to cellular localization and tissue integrity. It is highly expressed in the placenta (PLC)and is overexpressed by many types of cancer. P-cadherin levels in colorectal cancer (CRC) remains poorly characterized. This study's purpose was to determine P-cadherin expression in CRC and normal tissues and to assess plasma CDH3 levels in order to determine the relationship, if any, between cancer stage, P-cadherin expression and plasma CDH3 levels...
September 2017: Oncoscience
https://www.readbyqxmd.com/read/29142904/kras-g12d-upregulates-notch-signaling-to-induce-gallbladder-tumorigenesis-in-mice
#2
Wen-Cheng Chung, Junqing Wang, Yunyun Zhou, Keli Xu
Background: Kras mutations and increased Notch activation occur frequently in gallbladder cancer. However, their roles in gallbladder carcinogenesis have not been defined. This study was aimed at determining whether expression of mutant Kras was sufficient to induce gallbladder carcinoma and whether Notch deregulation played a role in this context. Methods: We determined Cre recombination activity of Pdx1-Cre in the gallbladder using a reporter strain and examined gallbladder tumor development in the Kras(LSL- G12D/+);Pdx1-Cre mice...
September 2017: Oncoscience
https://www.readbyqxmd.com/read/29142903/beti-induction-of-mitotic-catastrophe-towing-the-lin9
#3
EDITORIAL
Sylvia S Gayle, Jennifer M Sahni, Ruth A Keri
No abstract text is available yet for this article.
September 2017: Oncoscience
https://www.readbyqxmd.com/read/29142902/gm-csf-promotes-a-supportive-adipose-and-lung-microenvironment-in-metastatic-breast-cancer
#4
EDITORIAL
Francesca Reggiani, Francesco Bertolini
No abstract text is available yet for this article.
September 2017: Oncoscience
https://www.readbyqxmd.com/read/29142901/exposing-the-deadly-dark-side-of-apoptotic-cancer-stem-cells
#5
EDITORIAL
Goodwin G Jinesh
No abstract text is available yet for this article.
September 2017: Oncoscience
https://www.readbyqxmd.com/read/29142900/a-novel-dna-damage-induced-alternative-splicing-pathway-that-regulates-p53-and-cellular-senescence-markers
#6
EDITORIAL
Jing Chen, Michael B Kastan
No abstract text is available yet for this article.
September 2017: Oncoscience
https://www.readbyqxmd.com/read/29142899/enhancing-the-antitumor-potency-of-t-cells-redirected-by-bispecific-antibodies
#7
EDITORIAL
Chien-Hsing Chang, David M Goldenberg
No abstract text is available yet for this article.
September 2017: Oncoscience
https://www.readbyqxmd.com/read/29142898/intrinsic-and-environmental-factors-in-intrahepatic-cholangiocarcinoma-development
#8
EDITORIAL
Detian Yuan, María García-Beccaria, Mathias Heikenwalder
No abstract text is available yet for this article.
September 2017: Oncoscience
https://www.readbyqxmd.com/read/29142897/drug-induced-activation-of-junk-dna-a-path-to-combat-cancer-therapy-resistance
#9
EDITORIAL
Marie Classon, Kelly LaMarco, Daniel D De Carvalho
No abstract text is available yet for this article.
September 2017: Oncoscience
https://www.readbyqxmd.com/read/28966943/understanding-the-influence-of-patient-demographics-on-disease-severity-treatment-strategy-and-survival-outcomes-in-merkel-cell-carcinoma-a-surveillance-epidemiology-and-end-results-study
#10
Harib H Ezaldein, Alessandra Ventura, Nicolaas P DeRuyter, Emily S Yin, Alessandro Giunta
OBJECTIVE: To identify trends in patient presentation and outcomes data that may guide the development of clinical algorithms on Merkel Cell Carcinoma (MCC). METHODS: We performed a retrospective cohort study searching in the National Cancer Institute's SEER registry for documented MCC cases from 1986-2013. No exclusion criteria were applied. We hereby identified 7,831 original MCC entries. Demographics, staging, and socioeconomic characteristics were identified and treatment modality likelihoods and survival data were calculated via logistic regression and Kaplan-Meier statistical modeling...
July 2017: Oncoscience
https://www.readbyqxmd.com/read/28966942/beta-adrenergic-receptors-are-expressed-across-diverse-cancers
#11
Steven L Rains, Clarissa N Amaya, Brad A Bryan
Based largely on retrospective analyses and a handful of prospective case reports, pharmacological inhibition of the beta adrenergic receptors using beta blockers has shown clinical anti-cancer efficacy in reproductive cancers, as well as angiosarcoma and multiple myeloma. Because of the potential promise of beta blockers as an adjunct to standard anti-cancer therapy, it is imperative to identify other tumor types expressing beta adrenergic (β-AR) receptors so future preclinical and clinical studies can be directed at the most promising tumor targets...
July 2017: Oncoscience
https://www.readbyqxmd.com/read/28966941/increased-expression-of-the-tight-junction-protein-tjp1-zo-1-is-associated-with-upregulation-of-taz-tead-activity-and-an-adult-tissue-stem-cell-signature-in-carfilzomib-resistant-multiple-myeloma-cells-and-high-risk-multiple-myeloma-patients
#12
Irene Riz, Robert G Hawley
Tight junction protein 1 (TJP1) has recently been proposed as a biomarker to identify multiple myeloma (MM) patients most likely to respond to bortezomib- and carfilzomib-based proteasome inhibitor regimens. Herein we report increased expression of TJP1 during the adaptive response mediating carfilzomib resistance in the LP-1/Cfz MM cell line. Moreover, increased TJP1 expression delineated a subset of relapsed/refractory MM patients on bortezomib-based therapy sharing an LP-1/Cfz-like phenotype characterized by activation of interacting transcriptional effectors of the Hippo signaling cascade (TAZ and TEAD1) and an adult tissue stem cell signature...
July 2017: Oncoscience
https://www.readbyqxmd.com/read/28966940/defects-in-mismatch-repair-the-achilles-heel-of-estrogen-receptor-positive-breast-cancer-with-intrinsic-endocrine-therapy-resistance
#13
EDITORIAL
Svasti Haricharan, Matthew J Ellis
No abstract text is available yet for this article.
July 2017: Oncoscience
https://www.readbyqxmd.com/read/28966939/pure-ctcs-advanced-wgs-and-precise-personalized-combination-therapies
#14
EDITORIAL
Brock A Peters, John W Park, Radoje Drmanac
No abstract text is available yet for this article.
July 2017: Oncoscience
https://www.readbyqxmd.com/read/28966938/rna-processing-a-new-player-of-genomic-instability-in-multiple-myeloma
#15
EDITORIAL
Matteo Marchesini, Elena Fiorini, Simona Colla
No abstract text is available yet for this article.
July 2017: Oncoscience
https://www.readbyqxmd.com/read/28966937/origin-and-mechanism-of-neuroblastoma
#16
EDITORIAL
Shoma Tsubota, Kenji Kadomatsu
No abstract text is available yet for this article.
July 2017: Oncoscience
https://www.readbyqxmd.com/read/28966936/curing-glioblastoma-oncolytic-hsv-il12-and-checkpoint-blockade
#17
EDITORIAL
Dipongkor Saha, Robert L Martuza, Samuel D Rabkin
No abstract text is available yet for this article.
July 2017: Oncoscience
https://www.readbyqxmd.com/read/28781988/multiple-response-regression-analysis-links-magnetic-resonance-imaging-features-to-de-regulated-protein-expression-and-pathway-activity-in-lower-grade-glioma
#18
Michael Lehrer, Anindya Bhadra, Visweswaran Ravikumar, James Y Chen, Max Wintermark, Scott N Hwang, Chad A Holder, Erich P Huang, Brenda Fevrier-Sullivan, John B Freymann, Arvind Rao
BACKGROUND AND PURPOSE: Lower grade gliomas (LGGs), lesions of WHO grades II and III, comprise 10-15% of primary brain tumors. In this first-of-a-kind study, we aim to carry out a radioproteomic characterization of LGGs using proteomics data from the TCGA and imaging data from the TCIA cohorts, to obtain an association between tumor MRI characteristics and protein measurements. The availability of linked imaging and molecular data permits the assessment of relationships between tumor genomic/proteomic measurements with phenotypic features...
May 2017: Oncoscience
https://www.readbyqxmd.com/read/28781987/next-generation-sequencing-of-carcinoma-of-unknown-primary-reveals-novel-combinatorial-strategies-in-a-heterogeneous-mutational-landscape
#19
Ishwaria M Subbiah, Apostolia Tsimberidou, Vivek Subbiah, Filip Janku, Sinchita Roy-Chowdhuri, David S Hong
BACKGROUND: Advanced carcinoma of unknown primary (CUP) has limited effective therapeutic options given the phenotypic and genotypic diversity. To identify future novel therapeutic strategies we conducted an exploratory analysis of next-generation sequencing (NGS) of relapsed, refractory CUP. METHODS: We identified patients in our phase I clinic where archival tissue was available for a targeted NGS CLIA-certified assay. RESULTS: Of 17 patients tested, 15 (88%) demonstrated genomic alterations (median 2 aberrations; range 0-8, total 59 alterations)...
May 2017: Oncoscience
https://www.readbyqxmd.com/read/28781986/notch-controls-endothelial-cells
#20
EDITORIAL
Juan Rodriguez-Vita, Fabian Tetzlaff, Andreas Fischer
No abstract text is available yet for this article.
May 2017: Oncoscience
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