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Oncoscience

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https://www.readbyqxmd.com/read/29556516/high-dimensional-regression-analysis-links-magnetic-resonance-imaging-features-and-protein-expression-and-signaling-pathway-alterations-in-breast-invasive-carcinoma
#1
Michael Lehrer, Anindya Bhadra, Sathvik Aithala, Visweswaran Ravikumar, Youyun Zheng, Basak Dogan, Emerlinda Bonaccio, Elizabeth S Burnside, Elizabeth Morris, Elizabeth Sutton, Gary J Whitman, Jose Net, Kathy Brandt, Marie Ganott, Margarita Zuley, Arvind Rao
Background: Imaging features derived from MRI scans can be used for not only breast cancer detection and measuring disease extent, but can also determine gene expression and patient outcomes. The relationships between imaging features, gene/protein expression, and response to therapy hold potential to guide personalized medicine. We aim to characterize the relationship between radiologist-annotated tumor phenotypic features (based on MRI) and the underlying biological processes (based on proteomic profiling) in the tumor...
January 2018: Oncoscience
https://www.readbyqxmd.com/read/29556515/targeting-focal-adhesion-kinase-overcomes-erlotinib-resistance-in-smoke-induced-lung-cancer-by-altering-phosphorylation-of-epidermal-growth-factor-receptor
#2
Hitendra S Solanki, Remya Raja, Alex Zhavoronkov, Ivan V Ozerov, Artem V Artemov, Jayshree Advani, Aneesha Radhakrishnan, Niraj Babu, Vinuth N Puttamallesh, Nazia Syed, Vishalakshi Nanjappa, Tejaswini Subbannayya, Nandini A Sahasrabuddhe, Arun H Patil, T S Keshava Prasad, Daria Gaykalova, Xiaofei Chang, Rachana Sathyendran, Premendu Prakash Mathur, Annapoorni Rangarajan, David Sidransky, Akhilesh Pandey, Evgeny Izumchenko, Harsha Gowda, Aditi Chatterjee
EGFR-based targeted therapies have shown limited success in smokers. Identification of alternate signaling mechanism(s) leading to TKI resistance in smokers is critically important. We observed increased resistance to erlotinib in H358 NSCLC (non-small cell lung carcinoma) cells chronically exposed to cigarette smoke (H358-S) compared to parental cells. SILAC-based mass-spectrometry approach was used to study altered signaling in H358-S cell line. Importantly, among the top phosphosites in H358-S cells we observed hyperphosphorylation of EGFR (Y1197) and non-receptor tyrosine kinase FAK (Y576/577)...
January 2018: Oncoscience
https://www.readbyqxmd.com/read/29556514/determinant-factors-for-chronic-kidney-disease-after-partial-nephrectomy
#3
REVIEW
Oscar D Martín, Heilen Bravo, Marcos Arias, Diego Dallos, Yesica Quiroz, Luis G Medina, Giovanni E Cacciamani, Raul G Carlini
The objective of this review is to evaluate the factors that determine the development or deterioration of Chronic Kidney Disease (CKD) after partial nephrectomy (PN). When current literature is reviewed, it is found that factors that influence renal function after partial nephrectomy, are multifactorial. Those are divided into pre-surgical factors, such as hypertension, diabetes mellitus, urolithiasis, obesity, metabolic syndrome among others; intra-surgical factors, like the surgical technique used, the remaining healthy tissue, the experience of the surgeon, the time and type of ischemia among others...
January 2018: Oncoscience
https://www.readbyqxmd.com/read/29556513/re-thinking-the-preclinical-development-of-gbm-therapeutics
#4
EDITORIAL
Érika Cosset, Sara M Weis, David A Cheresh
No abstract text is available yet for this article.
January 2018: Oncoscience
https://www.readbyqxmd.com/read/29556512/in-quest-for-leukemia-initiating-cells-in-aml
#5
EDITORIAL
Maria De Grandis, Stéphane Jc Mancini, Michel Aurrand-Lions
No abstract text is available yet for this article.
January 2018: Oncoscience
https://www.readbyqxmd.com/read/29556511/precision-medicine-meets-the-dna-damage-response-in-pancreatic-cancer
#6
EDITORIAL
Lukas Perkhofer, Anett Illing, Johann Gout, Pierre-Olivier Frappart, Alexander Kleger
No abstract text is available yet for this article.
January 2018: Oncoscience
https://www.readbyqxmd.com/read/29556510/targeting-protein-myristoylation-for-the-treatment-of-prostate-cancer
#7
EDITORIAL
Essilvo Sulejmani, Houjian Cai
No abstract text is available yet for this article.
January 2018: Oncoscience
https://www.readbyqxmd.com/read/29556509/coaching-tumor-infiltrating-cd8-t-cells-to-eat-right
#8
EDITORIAL
Ral Kurupati, Hildegund Cj Ertl
No abstract text is available yet for this article.
January 2018: Oncoscience
https://www.readbyqxmd.com/read/29344558/therapeutic-potential-of-bleomycin-plus-suicide-or-interferon-%C3%AE-gene-transfer-combination-for-spontaneous-feline-and-canine-melanoma
#9
Lucrecia Agnetti, Chiara Fondello, Marcela S Villaverde, Gerardo C Glikin, Liliana M E Finocchiaro
We originated and characterized melanoma cell lines derived from tumors of two feline and two canine veterinary patients. These lines reestablished the morphology, physiology and cell heterogeneity of their respective parental tumors. We evaluated the cytotoxicity of bleomycin (BLM) alone, or combined with interferon-β (IFN-β) or HSVtk/GCV suicide gene (SG) lipofection on these cells. Although the four animals presented stage III disease (WHO system), SG treated feline tumors displayed stable disease in vivo, while the canine ones exhibited partial response...
November 2017: Oncoscience
https://www.readbyqxmd.com/read/29344557/in-colonic-%C3%AF-0-rho0-cells-reduced-mitochondrial-function-mediates-transcriptomic-alterations-associated-with-cancer
#10
Harrison M Penrose, Sandra Heller, Chloe Cable, Hani Nakhoul, Nate Ungerleider, Melody Baddoo, Zachary F Pursell, Erik K Flemington, Susan E Crawford, Suzana D Savkovic
Background: Mitochondrial reprogramming has emerged as a hallmark of cancer pathobiology. Although it is believed this reprogramming is essential for cancer cells to thrive, how it supports cancer pathobiology is unclear. We previously generated colonic ρ0 (rho0) cells with reduced mitochondrial energy function and acquired their transcriptional signature. Here, we utilized a bioinformatics approach to identify their changes linked to cancer pathobiology. Methods: Human colon cancer HCT116 cells, control and ρ0, were used for qPCR...
November 2017: Oncoscience
https://www.readbyqxmd.com/read/29344556/extracellular-matrix-composition-modulates-angiosarcoma-cell-attachment-and-proliferation
#11
Noel L Shaheen, Esha Kataria, Jocelyn Antony, Dana Galvan, Yessenia Ballou, Brad A Bryan
Angiosarcoma is a rare and generally fatal tumor composed of aberrant cells of endothelial origin. Because of its infrequency in humans, very little is known about the growth requirements of this vascular sarcoma. Unlike the rapidly proliferating solid tumors from which they are isolated from, many of the established angiosarcoma cell lines exhibit less than robust growth in culture and often fail to form tumors in xenograft models. In order to better understand angiosarcoma in vitro growth conditions, we focused on a singular aspect of their culture-adhesion to the extracellular matrix-in order to identify attachment substrates that may facilitate and/or enhance their growth in tissue culture...
November 2017: Oncoscience
https://www.readbyqxmd.com/read/29344555/destroying-the-androgen-receptor-ar-potential-strategy-to-treat-advanced-prostate-cancer
#12
EDITORIAL
Ramesh Narayanan, Suriyan Ponnusamy, Duane D Miller
No abstract text is available yet for this article.
November 2017: Oncoscience
https://www.readbyqxmd.com/read/29344554/pulling-the-plug-halting-cancer-s-theft-of-mitochondria
#13
EDITORIAL
Christopher R Marlein, Lyubov Zaitseva, Stuart A Rushworth
No abstract text is available yet for this article.
November 2017: Oncoscience
https://www.readbyqxmd.com/read/29344553/reprogramming-patient-derived-tumor-cells-generates-model-cell-lines-for-tuberous-sclerosis-associated-lymphangioleiomyomatosis
#14
EDITORIAL
Lisa M Julian, William L Stanford
No abstract text is available yet for this article.
November 2017: Oncoscience
https://www.readbyqxmd.com/read/29344552/collagen-and-calcium-binding-egf-domains-1-ccbe1-in-cancer-a-new-role-past-lymphatics
#15
EDITORIAL
Aruz Mesci, Stanley K Liu
No abstract text is available yet for this article.
November 2017: Oncoscience
https://www.readbyqxmd.com/read/29344551/cell-autonomous-and-non-autonomous-functions-of-s100a4-in-regulating-stemness-mesenchymal-transition-and-metastasis
#16
EDITORIAL
Bikesh Nirala, David Baskin, Kyuson Yun
No abstract text is available yet for this article.
November 2017: Oncoscience
https://www.readbyqxmd.com/read/29344550/neutrophils-and-anti-cancer-immunity-a-paradigm-shift-in-cancer-immunotherapy
#17
EDITORIAL
Rebecca Sturey, Akash Patnaik
No abstract text is available yet for this article.
November 2017: Oncoscience
https://www.readbyqxmd.com/read/29344549/e-cadherin-and-k-ras-implications-of-a-newly-developed-model-of-gastric-cancer
#18
EDITORIAL
Jacob E Till, Sam S Yoon, Sandra Ryeom
No abstract text is available yet for this article.
November 2017: Oncoscience
https://www.readbyqxmd.com/read/29344548/recombinant-adamts-13-in-thrombotic-thrombocytopenic-purpura
#19
EDITORIAL
Marie Scully, Christopher Hibbard, Bruce Ewenstein
No abstract text is available yet for this article.
November 2017: Oncoscience
https://www.readbyqxmd.com/read/29344547/mesenchymal-stem-cells-in-breast-cancer-response-to-chemical-and-mechanical-stimuli
#20
EDITORIAL
Seiichiro Ishihara, Suzanne M Ponik, Hisashi Haga
No abstract text is available yet for this article.
November 2017: Oncoscience
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