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American Journal of Clinical and Experimental Urology

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https://www.readbyqxmd.com/read/29666839/the-structure-of-the-nucleus-in-normal-and-neoplastic-prostate-cells-untangling-the-role-of-type-2-dna-topoisomerases
#1
REVIEW
William G Nelson, Michael C Haffner, Srinivasan Yegnasubramanian
Donald S. Coffey, a pioneer in the study of the structural basis of mammalian genome organization, was fascinated by DNA topoisomerases, chemo-mechanical enzymes that could catalyze changes in DNA structure. Work initiated in his laboratory and carried on with his influence and inspiration has led to the elucidation of specific roles for each of the two type 2 topoisomerases in DNA replication, RNA transcription, and androgen action in prostate cells. TOP2A principally acts in DNA synthesis elongation to prevent tangling of daughter DNA molecules during genome replication and mitotic segregation; TOP2B is required for androgen-stimulation of target gene transcription...
2018: American Journal of Clinical and Experimental Urology
https://www.readbyqxmd.com/read/29666838/a-brief-history-of-intracrine-androgen-metabolism-by-castration-recurrent-prostate-cancer
#2
REVIEW
James L Mohler
This mini-review describes the evolution of the concept of intracrine androgen metabolism by prostate cancer during androgen deprivation therapy. Persistence of androgen receptor protein in the face of castrate circulating levels of testosterone could not be explained fully by hypersensitization or mutation of the androgen receptor. The hypothesis that castration-recurrent prostate cancer produced its own testosterone was proven using radioimmunoassay and mass spectrometry methods adopted for use in prostate tissue...
2018: American Journal of Clinical and Experimental Urology
https://www.readbyqxmd.com/read/29666837/cancer-telomeres-and-white-crows
#3
REVIEW
Alan K Meeker
This mini-review article discusses past and present prostate-focused research on telomere and telomerase biology conducted at Johns Hopkins, through the eyes of a Donald S Coffey trainee. Included are past discoveries of abnormalities in telomere biology in the context of prostate cancer and its pre-malignant precursor prostatic intraepithelial neoplasia (PIN); the finding that telomerase activity is androgen-regulated in the prostate, and the potential role of telomerase in prostate epithelial stem cells. Also reviewed are more recent results showing that in situ telomere length measurements in patient tissue specimens may have utility in risk assessment and as a prognostic biomarker...
2018: American Journal of Clinical and Experimental Urology
https://www.readbyqxmd.com/read/29666836/organization-of-sperm-dna-by-the-nuclear-matrix
#4
REVIEW
William Steven Ward
In early years, Dr. Donald S. Coffey fostered the development of a new model for the organization of DNA in the sperm nucleus that had many unexpected similarities to that of somatic cells. This was surprising because it was well known that mammalian sperm DNA is more compact than the DNA in mitotic chromosomes, and the fact that some of the major structural components of somatic cell DNA organization were retained in the sperm cell was not predicted. The highly compact sperm DNA is organized into loop domains that are attached at their bases to a proteinaceous nuclear matrix, at specific matrix attachment regions (MARs)...
2018: American Journal of Clinical and Experimental Urology
https://www.readbyqxmd.com/read/29666835/aptamers-and-apple-pies-a-mini-review-of-psma-aptamers-and-lessons-from-donald-s-coffey
#5
REVIEW
Shawn E Lupold
This mini-review article is part of a special issue dedicated to Donald S. Coffey, a pioneer translational research scientist, exemplary mentor, and leader in urologic and urologic oncology research. This article first briefly reflects on life and scientific lessons from Don Coffey. It then reviews the development of two prostate cancer targeting RNA aptamers, xPSM-A9 and xPSM-A10, through in vitro selection for aptamers that bind to the extracellular domain of the Prostate Specific Membrane Antigen (PSMA)...
2018: American Journal of Clinical and Experimental Urology
https://www.readbyqxmd.com/read/29666834/androgen-action-in-prostate-function-and-disease
#6
REVIEW
Partha P Banerjee, Subhadra Banerjee, Terry R Brown, Barry R Zirkin
Benign prostatic hyperplasia (BPH) is an enlargement of the prostate gland that is frequently found in aging men. Androgens are essential for the development and differentiated function of the prostate, as well as for proliferation and survival of prostatic cells. In man, dog and rodent, there are age-related decreases in serum testosterone. Despite the lower serum testosterone levels, benign prostatic hyperplasia increases with age in men and dogs, while age-dependent prostatic hyperplasia develops in the dorsal and lateral lobes of the rat prostate...
2018: American Journal of Clinical and Experimental Urology
https://www.readbyqxmd.com/read/29666833/resolving-the-coffey-paradox-what-does-the-androgen-receptor-do-in-normal-vs-malignant-prostate-epithelial-cells
#7
REVIEW
John T Isaacs
Donald Straley Coffey completed his 85 year life's journey on November 9, 2017. In his wake, he left a legion of inspired and loyal students, fellows, and faculty colleagues from all over the world to carry on his passion both for life in general and his 50 year quest to conquer cancer. Early in his career, Dr. Coffey developed a series of animal models to study how androgen regulates the growth of both normal and abnormal prostatic epithelium. As part of these early studies, Dr. Coffey uncovered a paradox in that anti-androgen treatment given at the "wrong" time paradoxically enhanced, not inhibited, normal prostate growth...
2018: American Journal of Clinical and Experimental Urology
https://www.readbyqxmd.com/read/29666832/structure-and-function-analysis-in-circulating-tumor-cells-using-nanotechnology-to-study-nuclear-size-in-prostate-cancer
#8
REVIEW
Nu Yao, Yu-Jen Jan, Shirley Cheng, Jie-Fu Chen, Leland Wk Chung, Hsian-Rong Tseng, Edwin M Posadas
Professor Donald Coffey and his laboratory pioneered studies showing the relationships between nuclear shape and cellular function. In doing so, he and his students established the field of nuclear morphometry in prostate cancer. By using perioperative tissues via biopsies and surgical sampling, Dr. Coffey's team discovered that nuclear shape and other pathologic features correlated with clinical outcome measures. Cancer cells also exist outside of solid tumor masses as they can be shed from both primary and metastatic lesions into the circulatory system...
2018: American Journal of Clinical and Experimental Urology
https://www.readbyqxmd.com/read/29666831/donald-s-coffey-a-man-who-meant-so-much-to-so-many
#9
EDITORIAL
William Isaacs
No abstract text is available yet for this article.
2018: American Journal of Clinical and Experimental Urology
https://www.readbyqxmd.com/read/29666830/two-minds-create-a-third-an-exploration-of-the-universe-cancer-and-symmetry-with-donald-s-coffey
#10
EDITORIAL
J James Frost
No abstract text is available yet for this article.
2018: American Journal of Clinical and Experimental Urology
https://www.readbyqxmd.com/read/29666829/allowing-awe-in-life
#11
EDITORIAL
Daniel E Epner
No abstract text is available yet for this article.
2018: American Journal of Clinical and Experimental Urology
https://www.readbyqxmd.com/read/29666828/ten-unanswered-questions-in-cancer-if-this-is-true-what-does-it-imply
#12
EDITORIAL
Sarah R Amend, Amber E de Groot, Gonzalo Torga, Haley D Axelrod, Diane K Reyes, Kenneth C Valkenburg, Stephanie A Glavaris, Kenneth J Pienta
No abstract text is available yet for this article.
2018: American Journal of Clinical and Experimental Urology
https://www.readbyqxmd.com/read/29666827/donald-s-coffey-the-brady-long-rifles-and-the-war-on-prostate-cancer
#13
EDITORIAL
Markham C Luke
No abstract text is available yet for this article.
2018: American Journal of Clinical and Experimental Urology
https://www.readbyqxmd.com/read/29666826/dr-coffey-s-visionary-contributions-to-urological-research-in-china-and-japan
#14
EDITORIAL
Jun Shimazaki, Leland Wk Chung, Haiyen E Zhau, Tomohiko Ichikawa
No abstract text is available yet for this article.
2018: American Journal of Clinical and Experimental Urology
https://www.readbyqxmd.com/read/29531971/bcl-2-and-bcl-xl-expression-are-down-regulated-in-benign-prostate-hyperplasia-nodules-and-not-affected-by-finasteride-and-or-celecoxib
#15
Feng Li, Laura E Pascal, Jianhua Zhou, Yibin Zhou, Ke Wang, Anil V Parwani, Rajiv Dhir, Peng Guo, Dalin He, Joel B Nelson, Zhou Wang
The mechanisms involved in the development of benign prostatic hyperplasia (BPH) are poorly understood. One potential mechanism involved in BPH pathogenesis may involve altered expression of genes related to apoptosis and proliferation because reduced cell death and increased proliferation are thought to contribute to prostatic enlargement. This study examined the expression of B-cell lymphoma 2 (BCL-2) and B-cell lymphoma-extra large (BCL-XL), two important anti-apoptosis factors that are also capable of inhibiting cell proliferation via accelerated G1 arrest or delayed G1/S transition, using immunostaining in simple prostatectomy BPH specimens from patients naïve to androgen manipulation...
2018: American Journal of Clinical and Experimental Urology
https://www.readbyqxmd.com/read/29181438/parsley-mechanism-as-antiurolithiasis-remedy
#16
Fayed Al-Yousofy, Hussein Gumaih, Hassan Ibrahim, Afrah Alasbahy
Parsley is a medicinal plant used widely in urolithiasis. The present study aimed to evaluate the antiurolithiatic effect of parsley and its mechanism. 24 rats divided into four groups: group A (negative control), group B (positive control), group C (cystone® group) and group D (parsley group). Group B were treated with EG and Ammonium chloride (AC). Group C were treated as B plus cystone® and group D was treated as B plus parsley. The period of experiment was 15 days. Urine samples were analysis on days 0 and 15 days...
2017: American Journal of Clinical and Experimental Urology
https://www.readbyqxmd.com/read/29181437/clinical-features-of-patients-treated-by-peritoneal-dialysis-for-over-a-decade
#17
Mengli Tong, Yuhui Wang, Jun Ni, Ning Weng, Chuanxia Chen, Hongyu Chen, Lindholm Bengt
BACKGROUND: Peritoneal dialysis (PD) is well-established as renal replacement therapy in end stage renal disease and has survival rates similar or better than hemodialysis (HD) for the initial years on dialysis therapy. However retention rate is lower due to higher technique failure rates than in HD and few patients stay on PD for more than 10 years (PD>10 yrs ). Here we investigated clinical features characterizing PD>10 yrs patients. PATIENTS AND METHODS: In a single center study of 450 prevalent PD patients, 35 PD>10 yrs patients (n=35) were compared with patients (n=415) who had been on PD for shorter periods of time in terms of clinical characteristics...
2017: American Journal of Clinical and Experimental Urology
https://www.readbyqxmd.com/read/29181436/molecular-mechanisms-involving-prostate-cancer-racial-disparity
#18
REVIEW
Cansu Karakas, Cassie Wang, Fangming Deng, Hongying Huang, Dongwen Wang, Peng Lee
Prostate cancer (PCa) is the second leading cause of cancer-related deaths in the United States. The African (AA) descent has greater incidence and mortality rates of PCa as compared to Caucasian (CA) men. While socioeconomic differences across racial groups contribute to disparity in PCa, increasing evidence points that genetic and molecular alterations play important roles in racial disparities associated with PCa. In this review, we focus on genetic and molecular influences that contribute to racial disparity between AA and CA men including: androgen and estrogen receptor signaling pathways, growth factors, apoptotic proteins, genetic, genomic and epigenetic alterations...
2017: American Journal of Clinical and Experimental Urology
https://www.readbyqxmd.com/read/29181435/organoid-culture-of-human-prostate-cancer-cell-lines-lncap-and-c4-2b
#19
Lin Ma, Jingwu Li, Qiang Nie, Qiuyang Zhang, Sen Liu, Dongxia Ge, Zongbing You
Organoids mimic the architecture and functions of a small organ. Organoid culture technique has been rapidly accepted by all research communities during the past decade to study stem cells, organ development and function, and patient-specific diseases. A protocol for organoid culture of human and mouse prostate epithelial and cancer tissues has been reported. However, organoid culture of the commonly used human prostate cancer cell lines has yet to be established. We followed the published protocol and performed organoid culture of LNCaP and C4-2B cells in MatrigelTM and organoid culture medium for 14 days...
2017: American Journal of Clinical and Experimental Urology
https://www.readbyqxmd.com/read/29181434/androgen-receptor-ar-cistrome-in-prostate-differentiation-and-cancer-progression
#20
Fengtian Wang, Hari K Koul
Despite the progress in development of better AR-targeted therapies for prostate cancer (PCa), there is no curative therapy for castration-resistant prostate cancer (CRPC). Therapeutic resistance in PCa can be characterized in two broad categories of AR therapy resistance: the first and most prevalent one involves restoration of AR activity despite AR targeted therapy, and the second one involves tumor progression despite blockade of AR activity. As such AR remains the most attractive drug target for CRPC. Despite its oncogenic role, AR signaling also contributes to the maturation and differentiation of prostate luminal cells during development...
2017: American Journal of Clinical and Experimental Urology
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