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Ophthalmology and Therapy

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https://www.readbyqxmd.com/read/29127657/real-world-cost-savings-demonstrated-by-switching-patients-with-refractory-diabetic-macular-edema-to-intravitreal-fluocinolone-acetonide-iluvien-a-retrospective-cost-analysis-study
#1
Soon W Ch'ng, Alexander J Brent, Theodoros Empeslidis, Vasileios Konidaris, Somnath Banerjee
INTRODUCTION: It is hypothesized that using fluocinolone acetonide (FAc) implants such as Iluvien for the treatment of diabetic macular edema (DME) may reduce the total number of intravitreal injections and clinic visits, resulting in an overall treatment cost reduction. The primary aim of this study is to identify the real-world cost savings achievable in a tertiary National Health Service (NHS) hospital. METHODS: A retrospective cost analysis study was conducted...
November 10, 2017: Ophthalmology and Therapy
https://www.readbyqxmd.com/read/28905306/erratum-to-an-update-on-implants-for-minimally-invasive-glaucoma-surgery-migs
#2
Ejaz Ansari
No abstract text is available yet for this article.
September 13, 2017: Ophthalmology and Therapy
https://www.readbyqxmd.com/read/29086187/comparative-results-in-a-combined-procedure-of-intrastromal-corneal-rings-implantation-and-cross-linking-in-patients-with-keratoconus-a-retrospective-study
#3
Cristina Nicula, Radu Nicolae Pop, Dorin V Nicula
INTRODUCTION: Corneal thinning disorders caused by keratoconus often lead to protrusion, irregular astigmatism, and even perforation. Keratoconus, like other corneal ectasia, does not have a known cause. Severe cases of keratoconus may require correction or restoration of tectonic integrity of the cornea by surgical means. Intracorneal ring segments are a new modality in the treatment of corneal ectactic disorders. A new technique of stopping the evolution of keratoconus and strengthening the cornea is combining techniques of intrastromal corneal ring implantation and corneal collagen cross-linking...
December 2017: Ophthalmology and Therapy
https://www.readbyqxmd.com/read/29043565/eccentric-macular-hole-after-pars-plana-vitrectomy-for-epiretinal-membrane-without-internal-limiting-membrane-peeling-a-case-report
#4
Christina Garnavou-Xirou, Tina Xirou, Stamatina Kabanarou, Ilias Gkizis, Stavros Velissaris, Irini Chatziralli
INTRODUCTION: Postoperative eccentric macular hole formation is an uncommon complication after pars plana vitrectomy (PPV) without internal limiting membrane (ILM) peeling for the treatment of epiretinal membrane (ERM). We present a case of eccentric macular hole formation after PPV for ERM without ILM peeling. CASE REPORT: A 68-year-old male patient presented with ERM and visual acuity of 6/24 in his left eye. He underwent 23-gauge PPV without ILM peeling for treatment of ERM...
December 2017: Ophthalmology and Therapy
https://www.readbyqxmd.com/read/29022285/macular-hole-development-after-vitrectomy-for-floaters-a-case-report
#5
Andrea Appeltans, Marco Mura, Giulio Bamonte
INTRODUCTION: The purpose of this report is to describe a case of macular hole development after vitrectomy for floaters with induction of posterior vitreous detachment. CASE REPORT: A 44-year-old otherwise healthy man presented with visually debilitating floaters in his right eye; these had been present for more than 2 years. Preoperative examination was unremarkable in both eyes, apart from some degree of vitreous degeneration in the right eye. Preoperative visual acuity was 20/20 bilaterally...
December 2017: Ophthalmology and Therapy
https://www.readbyqxmd.com/read/28956287/use-of-the-controlled-adverse-environment-cae-in-clinical-research-a-review
#6
REVIEW
George W Ousler, David Rimmer, Lisa M Smith, Mark B Abelson
The many internal and external factors that contribute to the pathophysiology of dry eye disease (DED) create a difficult milieu for its study and complicate its clinical diagnosis and treatment. The controlled adverse environment (CAE(®)) model has been developed to minimize the variability that arises from exogenous factors and to exacerbate the signs and symptoms of DED by stressing the ocular surface in a safe, standardized, controlled, and reproducible manner. By integrating sensitive, specific, and clinically relevant endpoints, the CAE has proven to be a unique and adaptable model for both identifying study-specific patient populations with modifiable signs and symptoms, and for tailoring the evaluation of interventions in clinical research studies...
December 2017: Ophthalmology and Therapy
https://www.readbyqxmd.com/read/28936713/manual-removal-of-primary-posterior-capsular-plaques-using-retinal-end-grasping-forceps
#7
Gennady Landa, Khoa Pham
INTRODUCTION: Primary posterior capsular plaques can be highly adherent to the posterior capsule leading to possible posterior capsular rupture during attempted removal. Here we describe a novel method for posterior capsular plaque removal using a technique inspired by the experience of retina surgeon in the peeling of membranes from the posterior pole. METHODS: Retinal end-grasping forceps were used to peel the plaque from the posterior capsule. RESULTS: We have performed this technique on 12 eyes with successful removal of the posterior capsular plaque in all instances without compromise of the posterior capsule in any case...
December 2017: Ophthalmology and Therapy
https://www.readbyqxmd.com/read/28933042/anterior-chamber-changes-after-implantable-collamer-lens-implantation-in-high-myopia-using-pentacam-a-prospective-study
#8
Mohamed Nagy Elmohamady, Walid Abdelghaffar
INTRODUCTION: The objective of this study was to evaluate the changes of the anterior chamber (AC) of the eye after implantable Collamer lens (ICL) implantation in high myopia by using the Pentacam. METHODS: The prospective study included 34 high myopic patients (34 eyes). All patients were treated with Visian implantable Collamer lens (ICL) (Staar Surgical Co.) implantation. The Pentacam (Oculus) was used for all cases preoperatively and 1, 3 and 6 months postoperatively...
December 2017: Ophthalmology and Therapy
https://www.readbyqxmd.com/read/28933041/macular-hole-caused-by-retained-subfoveal-perfluorocarbon-that-subsequently-closed-after-its-spontaneous-resolution-a-case-report
#9
Reiko Tanabu, Yukihiko Suzuki, Kaori Suzuki, Shizuka Takahashi, Mitsuru Nakazawa, Hideyuki Mizutani
INTRODUCTION: To prevent local reduction in retinal function caused by retained subretinal perfluorocarbon liquid (PFCL), it has been noted that removal of PFCL under the fovea should be considered, with a vitrectomy selected for such removal. CASE REPORT: A vitrectomy was performed for traumatic retinal detachment during which PFCL was temporarily used as an intraocular tamponade for retina flattening. Following surgery, subfoveal PFCL was retained beneath the retina...
December 2017: Ophthalmology and Therapy
https://www.readbyqxmd.com/read/28849579/variations-in-treatment-delivery-for-patients-with-neovascular-amd-in-the-uk-results-from-an-ophthalmology-trainee-clinical-research-network-study
#10
Daren Hanumunthadu, Victoria A Nowak, Farida Hassan, Ibtesham Hossain, Darshak S Patel, Lamia Hamidovic, Dalia Abdulhussein, Isra Hausien, Esther Papamichael, Meena Arunakirinathan, Claudia Quijano, Sheena George, Praveen J Patel
INTRODUCTION: The aim of this study was to determine treatment delivery patterns for patients with neovascular age-related macular degeneration (nAMD) across the UK through an ophthalmology trainee research network delivered observational study. METHODS: Data were collected via an online tool by potential research collaborators identified by the Ophthalmology Trainee Clinical Trial Network (OCTN). Collaborators were asked to comment on periprocedural practices of treatment of nAMD in their eye unit including treatment location and injectors, clinical assessment and routine observation in patients undergoing intravitreal treatment...
December 2017: Ophthalmology and Therapy
https://www.readbyqxmd.com/read/28849554/corneal-hydrops-secondary-to-intrastromal-corneal-ring-intrusion-into-the-anterior-chamber-7%C3%A2-years-after-implantation-a-case-report
#11
Majid Moshirfar, Andrew E Bean, Jordan D Desautels, Orry C Birdsong
INTRODUCTION: This report describes the first known case of late-onset intrusion of an intrastromal ring segment into the anterior chamber due to posterior migration of a ring segment. To our knowledge, intrastromal ring segment penetration has only been shown to occur in the intraoperative or immediate postoperative period. We postulate that the perforation in this case is due to progressive thinning of the cornea, possibly in combination with habitual eye rubbing. CASE REPORT: A 44-year-old man presented with acute corneal hydrops related to penetration of Descemet's membrane and endothelium by an intrastromal ring segment implanted 7 years prior...
December 2017: Ophthalmology and Therapy
https://www.readbyqxmd.com/read/28819932/twice-daily-vs-once-daily-dosing-with-0-075-bromfenac-in-durasite-outcomes-from-a-14-day-phase-2-study
#12
William Trattler, Kamran Hosseini
INTRODUCTION: Bromfenac is a well-known topical ophthalmic nonsteroidal anti-inflammatory drug (NSAID) that is commercialized in the USA and other regions of the world. A new formulation, 0.075% bromfenac in DuraSite®, was developed to treat postoperative inflammation and reduce pain in patients who have undergone cataract surgery. We hypothesized that efficacy and safety would be enhanced with twice-daily (BID) dosing compared to once-daily (QD) dosing. METHODS: This was a multicenter, double-masked, comparative study in which 40 and 45 subjects were randomized to groups receiving BID dosing and QD dosing, respectively...
December 2017: Ophthalmology and Therapy
https://www.readbyqxmd.com/read/28808911/methicillin-resistant-staphylococcus-aureus-acute-keratitis-after-intracorneal-ring-segment-implantation
#13
Gonzalo García de Oteyza, Andrea Laiseca, Paola Sauvageot, Juan Álvarez de Toledo
INTRODUCTION: The purpose of this study was to report the first case of acute bacterial keratitis produced by methicillin-resistant Staphylococcus aureus after the implantation of two intracorneal ring segments during an uneventful procedure for treating keratoconus in a 13-year-old child. CASE REPORT: A patient with grade III keratoconus underwent an implantation of intracorneal ring segments with no complications during the procedure. Three days later, a whitish corneal infiltrate appeared in between the union of both corneal rings...
December 2017: Ophthalmology and Therapy
https://www.readbyqxmd.com/read/28795358/psychophysical-measurements-of-luminance-contrast-sensitivity-and-color-discrimination-with-transparent-and-blue-light-filter-intraocular-lenses
#14
Marcelo Fernandes da Costa, Augusto Paranhos Júnior, Claudio Luiz Lottenberg, Leonardo Cunha Castro, Dora Fix Ventura
INTRODUCTION: The purpose of this study was to measure luminance contrast sensitivity and color vision thresholdfs in normal subjects using a blue light filter lens and transparent intraocular lens material. METHODS: Monocular luminance grating contrast sensitivity was measured with Psycho for Windows (version 2.36; Cambridge Research Systems) at 3.0, 6.0, 12.0, 20.0, and 30.0 cycles per degree of visual angle (cpd) in 15 normal subjects (eight female), with a mean age of 21...
December 2017: Ophthalmology and Therapy
https://www.readbyqxmd.com/read/28791607/treatment-of-dry-eye-disease-with-autologous-platelet-rich-plasma-a-prospective-interventional-non-randomized-study
#15
Jorge L Alio, Alejandra E Rodriguez, Renan Ferreira-Oliveira, Dominika Wróbel-Dudzińska, Ahmed A Abdelghany
INTRODUCTION: The objective of this study was to evaluate the use of autologous platelet-rich plasma (PRP) eye drops as monotherapy for the treatment of moderate to severe cases of dry eye disease. METHODS: Three hundred and sixty-eight patients with moderate to severe dry eye disease (DED) were included in this prospective case series. Subjects were classified as evaporative DED (EDED) or aqueous deficient DED (ADDED). Improvement of the DED subjective symptoms, corneal fluorescein staining (CFS), and corrected distance visual acuity (BCVA) were evaluated...
December 2017: Ophthalmology and Therapy
https://www.readbyqxmd.com/read/28755306/keratoconus-treatment-algorithm
#16
REVIEW
Konstantinos D Andreanos, Kate Hashemi, Myrsini Petrelli, Konstantinos Droutsas, Ilias Georgalas, George D Kymionis
Keratoconus management has significantly changed over the last two decades. The advent of new interventions such as cornea cross-linking, intrastromal corneal ring segments, and combined treatments provide corneal clinicians a variety of treatment options for the visual rehabilitation of keratoconus patients. This review summarizes current evidence for these treatments and highlights their place in keratoconus management while new promising emerging therapies are being investigated.
December 2017: Ophthalmology and Therapy
https://www.readbyqxmd.com/read/28730285/an-update-on-implants-for-minimally-invasive-glaucoma-surgery-migs
#17
REVIEW
Ejaz Ansari
For several years, the gold standard for surgical treatment of glaucoma has been trabeculectomy. Although very successful at reducing intraocular pressure (IOP), there are several potential complications of trabeculectomy, including sight-threatening ones. This has stimulated much research aimed at the development of new and effective procedures to lower IOP with an enhanced safety profile. Minimally invasive glaucoma surgery (MIGS) procedures prioritise patient safety but also demonstrate efficacy in reducing IOP...
December 2017: Ophthalmology and Therapy
https://www.readbyqxmd.com/read/28669026/a-pilot-study-on-ocular-safety-and-efficacy-of-infliximab-as-an-antifibrotic-agent-after-experimental-glaucoma-filtration-surgery
#18
Eleni Nikita, Alexandre Moulin, Ioannis Vergados, Dimitrios Brouzas, Panagiotis G Theodossiadis
INTRODUCTION: Tumor necrosis factor-α (TNF-α) is a multifunctional, proinflammatory cytokine that mediates pleiotropic biological functions, especially inflammation and immunoregulation. We hypothesized that blocking TNF-α with a monoclonal antibody would decrease inflammation and subconjunctival scarring in an animal model of experimental filtration surgery. METHODS: In a randomized, prospective, masked-observer study, 30 New Zealand albino rabbits underwent glaucoma filtration surgery...
December 2017: Ophthalmology and Therapy
https://www.readbyqxmd.com/read/28643231/demodex-blepharitis-treated-with-a-novel-dilute-povidone-iodine-and-dmso-system-a-case-report
#19
Jesse S Pelletier, Kara Capriotti, Kevin S Stewart, Joseph A Capriotti
INTRODUCTION: Povidone-iodine aqueous solution is an antiseptic commonly used in ophthalmology for treatment of the ocular surface. Dimethylsulfoxide (DMSO) is a well-known skin penetration enhancer that is scarcely utilized in ophthalmic drug formulations. We describe here a low-dose formulation of 0.25% PVP-I in a gel containing DMSO for the treatment of Demodex blepharitis. CASE REPORT: A 95-year-old female presented with chronic blepharitis involving both the anterior and posterior eyelid margins...
December 2017: Ophthalmology and Therapy
https://www.readbyqxmd.com/read/28584936/a-review-of-nitric-oxide-for-the-treatment-of-glaucomatous-disease
#20
REVIEW
Joah Aliancy, W Daniel Stamer, Barbara Wirostko
Glaucoma is the leading cause of irreversible blindness worldwide, affecting 64.3 million people. An estimated 60.5 million people are affected by primary open angle glaucoma globally, and this will increase to 111.8 million by 2040. The definition of glaucoma has evolved greatly over time. Although multiple risk factors such as ischemia, inflammation, myopia, race, age and low ocular perfusion pressure may play a role, intraocular pressure (IOP) is still the main risk factor we can easily identify and modify...
December 2017: Ophthalmology and Therapy
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