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Ophthalmology and Therapy

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https://www.readbyqxmd.com/read/27909980/omalizumab-in-severe-refractory-vernal-keratoconjunctivitis-in-children-case-series-and-review-of-the-literature
#1
Serge Doan, Flore Amat, Eric Gabison, Sarah Saf, Isabelle Cochereau, Jocelyne Just
INTRODUCTION: Vernal keratoconjunctivis (VKC) is a severe form of pediatric ocular allergy, characterized by acute and chronic corneoconjunctival inflammation that may lead to visual sequelae. Although topical immunosuppressive drugs such as cyclosporine are usually effective, some severe forms may be refractory and require prolonged steroid therapy. Very few papers report the use of omalizumab in VKC in the literature. In the present study, we describe our clinical experience with omalizumab in severe VKC children...
December 1, 2016: Ophthalmology and Therapy
https://www.readbyqxmd.com/read/27900561/mineralocorticoid-antagonists-as-adjuncts-in-neovascular-age-related-macular-degeneration
#2
Kapil G Kapoor, Niket Todi, Alan L Wagner
INTRODUCTION: The purpose of this project was to evaluate the role of MR antagonists as an adjunct in patients with neovascular age-related macular degeneration (AMD) who have chronic subretinal fluid. METHODS: Inclusion criteria were patients with a diagnosis of neovascular AMD, who had completed at least six anti-VEGF injections, and had persistent subretinal fluid (SRF) on optical coherence tomography (OCT). Treatment with oral eplerenone was initiated and dose titrated according to protocol...
November 29, 2016: Ophthalmology and Therapy
https://www.readbyqxmd.com/read/27885592/normal-threshold-size-of-stimuli-in-children-using-a-game-based-visual-field-test
#3
Yanfang Wang, Zaria Ali, Siddharth Subramani, Susmito Biswas, Cecilia Fenerty, David B Henson, Tariq Aslam
INTRODUCTION: The aim of this study was to demonstrate and explore the ability of novel game-based perimetry to establish normal visual field thresholds in children. METHODS: One hundred and eighteen children (aged 8.0 ± 2.8 years old) with no history of visual field loss or significant medical history were recruited. Each child had one eye tested using a game-based visual field test 'Caspar's Castle' at four retinal locations 12.7° (N = 118) from fixation...
November 24, 2016: Ophthalmology and Therapy
https://www.readbyqxmd.com/read/27885591/the-impact-of-non-steroidal-anti-inflammatory-agents-after-phacoemulsification-on-quality-of-life-a-randomized-study
#4
Irini P Chatziralli, Theodoros N Sergentanis, Efstratios A Parikakis, Leonidas E Papazisis, Panagiotis Mitropoulos, Marilita M Moschos
INTRODUCTION: The purpose of our study was to investigate the impact of ketorolac addition to the well-established combination of antibiotic-steroid agent in terms of vision-related quality of life. METHODS: Patients were randomized to: (1) fixed combination of tobramycin 0.3%-dexamethasone 0.1%, one drop qid (n = 68) and (2) fixed combination of tobramycin 0.3%-dexamethasone 0.1%, one drop qid, plus ketorolac tromethamine 0.5%, one drop tid (n = 70). All patients completed the VFQ-25 questionnaire to assess their functional vision before cataract surgery and postoperatively on days 7, 28 and 42...
November 24, 2016: Ophthalmology and Therapy
https://www.readbyqxmd.com/read/27885590/payment-reform-needed-to-address-health-disparities-of-undiagnosed-diabetic-retinopathy-in-the-city-of-chicago
#5
Dustin D French, Jess J Behrens, Kathryn L Jackson, Abel N Kho, Theresa L Walunas, Charlesnika T Evans, Michael Mbagwu, Curtis E Margo, Paul J Bryar
INTRODUCTION: The Affordable Care Act (ACA) has expanded health coverage for thousands of Illinois residents. Expanded coverage, however, does not guarantee appropriate health care. Diabetes and its ocular complications serve as an example of how providers in underserved urban areas may not be able to keep up with new demand for labor- and technology-intensive health care unless changes in reimbursement policies are instituted. METHODS: A retrospective cohort study was conducted using medical encounter information from the Chicago HealthLNK Data Repository (HDR), an assembly of non-duplicated and de-identified patient medical records...
November 24, 2016: Ophthalmology and Therapy
https://www.readbyqxmd.com/read/27858333/optimizing-medical-management-in-patients-with-sight-threatening-diabetic-retinopathy
#6
Sunil Mamtora, Teresa Sandinha, Peter E Carey, David H W Steel
INTRODUCTION: Diabetic retinopathy is a leading cause of blindness in adults of working age. Patients with sight-threatening diabetic retinopathy (STDR) often have poor control of modifiable risk factors, including blood pressure and blood glucose. Patients in our eye department with STDR whose diabetes was managed only by their general practitioner (GP) were referred to a diabetes specialist. We have reviewed these referrals and assessed the control of modifiable risk factors in these patients at the time of referral...
November 17, 2016: Ophthalmology and Therapy
https://www.readbyqxmd.com/read/27837409/need-for-animal-models-of-meibomian-gland-dysfunction
#7
Louis Tong, Preeya K Gupta
Evaporative dry eye has gained increasing interest in recent years in academia, pharmaceutical, and medical device industries. The main cause of this type of dry eye is attributed to meibomian gland dysfunction (MGD). MGD is a diffuse abnormality of the meibomian glands characterised by terminal duct obstruction and eventually leading to signs and symptoms of dry eye. There have been only a few reported animal models of MGD, but recent advances are likely to lead to new models and better ways to assess the pathology in these animals...
November 11, 2016: Ophthalmology and Therapy
https://www.readbyqxmd.com/read/27815721/erratum-to-newly-diagnosed-primary-open-angle-glaucoma-randomized-to-2-trabecular-bypass-stents-or-prostaglandin-outcomes-through-36-months
#8
Steven D Vold, Lilit Voskanyan, Manfred Tetz, Gerd Auffarth, Imran Masood, Leon Au, Iqbal Ike K Ahmed, Hady Saheb
No abstract text is available yet for this article.
November 4, 2016: Ophthalmology and Therapy
https://www.readbyqxmd.com/read/27744531/uveitis-specialists-and-rheumatologists-select-different-therapies-for-idiopathic-non-necrotizing-anterior-scleritis
#9
Daniel J Ozzello, Jason R Kolfenbach, Alan G Palestine
INTRODUCTION: Uveitis specialists and rheumatologists treat patients with anterior scleritis, but data from controlled trials to guide management are scarce, making differences in treatment paradigms possible. METHODS: 1044 uveitis specialists and rheumatologists were surveyed regarding therapy for a patient with anterior scleritis. Respondents were asked to select first- and second-choice therapies and then reselect therapies assuming that the costs of all options were equal and that insurance approval was ensured...
October 15, 2016: Ophthalmology and Therapy
https://www.readbyqxmd.com/read/27709441/correlation-between-intraocular-pressure-and-central-corneal-thickness-in-persian-children
#10
Mahmood Nejabat, Fatemeh Heidary, Mohammad Reza Talebnejad, Ramin Salouti, Mohammad Hossein Nowroozzadeh, Masoumeh Masoumpour, Hamideh Mahdaviazad, Zahra Tajbakhsh, Maryam Keshtkar, Hossein Jamali, Mohammad Reza Khalili, Hossein Movahedan, Narges Roustaei, Reza Gharebaghi
INTRODUCTION: This study aimed to determine intraocular pressure (IOP) and central corneal thickness (CCT) measurements in healthy Persian children to find clinical reference values in this ethnicity. Additionally, we examined the possible relationship between these measurements. METHODS: This cross-sectional study included 262 eyes of 131 Persian primary school children between 6 and 13 years of age. All eyes were healthy and had no anterior or posterior segment abnormalities, corneal disease, or evidence of glaucoma...
October 5, 2016: Ophthalmology and Therapy
https://www.readbyqxmd.com/read/27638839/combined-glaucoma-tube-shunt-ahmed-and-fluocinolone-acetonide-retisert%C3%A2-implantation-compared-to-ahmed-alone-in-uveitic-glaucoma
#11
Mark Zivney, Phoebe Lin, Beth Edmunds, Mansi Parikh, Hana Takusagawa, Shandiz Tehrani
INTRODUCTION: Glaucoma is a known complication of uveitis, and may require glaucoma tube shunt implantation for intraocular pressure (IOP) control. The success of glaucoma tube shunt implantation in the setting of a local ocular steroid depot in uveitic glaucoma remains unknown. The purpose of this study was to determine whether patients who underwent combined glaucoma tube shunt (Ahmed) and fluocinolone acetonide (Retisert™, Bausch + Lomb, Bridgewater, NJ, USA) implantation have superior outcomes compared to patients with Ahmed implants only in the setting of uveitic glaucoma...
September 16, 2016: Ophthalmology and Therapy
https://www.readbyqxmd.com/read/27619226/ocriplasmin-for-treatment-of-vitreomacular-traction-an-update
#12
Mohammed Ali Khan, Julia A Haller
Pharmacologic vitreolysis with ocriplasmin, a 27 kilodalton serine protease, is an effective nonsurgical treatment option for vitreomacular traction (VMT). Data from phase III clinical studies, including the Microplasmin for Intravitreal Injection-Traction Release without Surgical Treatment (MIVI-TRUST) and Ocriplasmin for Treatment for Symptomatic Vitreomacular Adhesion Including Macular Hole (OASIS) studies, have demonstrated the treatment efficacy of ocriplasmin for VMT and full-thickness macular hole (FTMH)...
September 12, 2016: Ophthalmology and Therapy
https://www.readbyqxmd.com/read/27619225/newly-diagnosed-primary-open-angle-glaucoma-randomized-to-2-trabecular-bypass-stents-or-prostaglandin-outcomes-through-36-months
#13
Steven D Vold, Lilit Voskanyan, Manfred Tetz, Gerd Auffarth, Imran Masood, Leon Au, Iqbal Ike K Ahmed, Hady Saheb
PURPOSE: To examine outcomes through 36 months in phakic eyes with newly diagnosed primary open-angle glaucoma (POAG) naïve to therapy randomized to treatment with two trabecular micro-bypass stents or topical prostaglandin. METHODS: Subjects with POAG naïve to therapy, with intraocular pressure (IOP) ≥21 and ≤40 mmHg, were randomized to implantation of two stents or travoprost. Additional medication was to be prescribed post-treatment for elevated IOP or glaucomatous optic nerve findings...
September 12, 2016: Ophthalmology and Therapy
https://www.readbyqxmd.com/read/27613631/early-onset-of-ocular-neovascularization-after-hyperbaric-oxygen-therapy-in-a-patient-with-central-retinal-artery-occlusion
#14
Peter H Tang, Kevin Engel, David Wilkin Parke
Central retinal artery occlusion (CRAO) is an infarction to the retina that results in acute, frequently severe vision loss. Long-term complications such as ocular neovascularization (ONV) can occur and result in neovascular glaucoma and vitreous hemorrhage. Recent studies have explored acute hyperbaric oxygen (HBO) therapy as a promising treatment for CRAO to improve long-term vision potential; however, its effects on CRAO complications have not been well characterized. This study was conducted to better characterize the effects of HBO therapy on complications from CRAO...
September 9, 2016: Ophthalmology and Therapy
https://www.readbyqxmd.com/read/27601159/the-effect-of-scleral-buckling-surgery-on-choroidal-thickness-measured-by-enhanced-depth-optical-coherence-tomography-a-cross-sectional-study
#15
Sandra R Montezuma, Peter H Tang, Cory J Miller, Alla Kelly, Frederik J G M van Kuijk, Paul Drayna, Dara D Koozekanani
INTRODUCTION: To assess the anatomical changes taking place in the choroid after a scleral buckle (SB) procedure for retinal detachment repair. METHODS: This cross-sectional study looked at 23 adults with a history of unilateral retinal detachment repaired with a SB or other encircling element. The subjects underwent bilateral Enhanced Depth Spectral Domain Optical Coherence Tomography to image the choroid. The choroidal thickness (CT) was measured, and the non-operative eye was used as an internal control...
September 6, 2016: Ophthalmology and Therapy
https://www.readbyqxmd.com/read/27573498/differences-in-neuroticism-between-patients-with-glaucoma-who-have-discontinued-visits-to-ophthalmologists-and-those-who-make-regular-visits-implications-for-adherence-to-topical-glaucoma-medications
#16
Tadashi Nakano, Fumitoshi Kodaka, Hiroshi Tsuneoka
INTRODUCTION: Neuroticism is a personality trait often described in individuals with glaucoma (GLC), but is not necessarily representative of the total population of patients. There is a population of patients with GLC who are invisible to clinical ophthalmologists; in other words, those who once have been diagnosed with GLC, but spontaneously stop visiting an ophthalmologist. Little is known about their neuroticism personality trait. In the present study, the authors compared the level of neuroticism between patients no longer visiting an ophthalmologist and those who continue visit them regularly...
August 29, 2016: Ophthalmology and Therapy
https://www.readbyqxmd.com/read/27492380/prospective-observational-post-marketing-study-of-tafluprost-0-0015-timolol-0-5-combination-ophthalmic-solution-for-glaucoma-and-ocular-hypertension-short-term-efficacy-and-safety
#17
Yasutaka Takagi, Hirotaka Osaki, Tomohiro Yamashita, Yasuhiko Kai
INTRODUCTION: The intraocular pressure (IOP)-lowering effect and safety of tafluprost 0.0015%/timolol maleate 0.5% combination ophthalmic solution (Taf-TFC) were investigated in a real-world clinical setting. METHODS: A prospective up to 2-year (more than 1 year) observational study has been initiated to collect data on the IOP, conjunctival hyperemia score, corneal staining score, and adverse events suffered by patients with glaucoma or ocular hypertension treated at 3 months, and up to 2 years (more than 1 year) after initiating treatment with Taf-TFC...
August 4, 2016: Ophthalmology and Therapy
https://www.readbyqxmd.com/read/27484365/strategies-for-improving-patient-comfort-during-intravitreal-injections-results-from-a-survey-based-study
#18
Jessica Gomez, Dara D Koozekanani, Alex Z Feng, Mitchell Holt, Paul Drayna, Melissa R Mackley, Frederik J G M van Kuijk, Robert M Beardsley, Richard H Johnston, Joseph M Terry, Sandra R Montezuma
INTRODUCTION: Many ocular diseases require intravitreal injections of pharmacological agents. Optimizing patients' experiences during injections is important to ensure compliance and maintenance of quality of life. The objective of this study was to identify strategies to help alleviate discomfort during intravitreal injections. METHODS: A cross-sectional study surveying 128 patients during clinic visits between 2014 and 2015 in two outpatient Retina Clinics (one academic and one private)...
August 2, 2016: Ophthalmology and Therapy
https://www.readbyqxmd.com/read/27457724/primary-baerveldt-shunt-implantation-outcomes-and-complications
#19
Abed Namavari, Robert A Hyde, Daniel Wang, Thasarat S Vajaranant, Ahmad A Aref
INTRODUCTION: This study is a retrospective case series to evaluate the outcomes and complications of Baerveldt glaucoma implant surgery (BGI) in patients without prior cataract or incisional glaucoma surgery. METHODS: Patients who underwent 350-mm(2) BGI through the Glaucoma Service of the University of Illinois at Chicago between 2010 and 2015 were included in this study. Outcome measures included age, sex, ethnicity, operated eye, preoperative diagnosis, preoperative, and sequential postoperative intraocular pressure (IOP), visual acuity, glaucoma medications, and postoperative complication and interventions...
July 25, 2016: Ophthalmology and Therapy
https://www.readbyqxmd.com/read/27339266/assessing-patients-with-asymptomatic-retinal-emboli-detected-at-retinal-screening
#20
Afsara A Ahmmed, Peter E Carey, David H W Steel, Teresa Sandinha
INTRODUCTION: Asymptomatic retinal emboli have been associated with diabetes, the presence of significant carotid artery stenosis (≥70%) and an increased risk of stroke. However, there is no clear guidance on how best to investigate and manage patients found to have asymptomatic retinal emboli. Therefore, this study aimed to assess the incidence of significant carotid artery stenosis in patients found to have asymptomatic retinal emboli at diabetic retinopathy screening, and to examine disease management approaches among these patients...
June 23, 2016: Ophthalmology and Therapy
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