journal
MENU ▼
Read by QxMD icon Read
search

Ophthalmology and Therapy

journal
https://www.readbyqxmd.com/read/29761367/in-vivo-pharmacokinetics-of-bromfenac-ophthalmic-solution-0-075-bromfenac-ophthalmic-solution-0-07-and-nepafenac-amfenac-ophthalmic-suspension-0-3-in-rabbits
#1
John D Sheppard, Paul C Cockrum, Angela Justice, Mark C Jasek
INTRODUCTION: Little is known of the ocular distribution characteristics of currently branded non-steroidal anti-inflammatory drugs (NSAIDs) in the United States. This study was designed to predict the ocular bioavailability characteristics in humans using Dutch Belted rabbits as a surrogate. Commercially available, topically-applied NSAIDs containing bromfenac or nepafenac/amfenac were evaluated. METHODS: 126 healthy adult Dutch Belted rabbits were randomly assigned to three treatment cohorts (BromSite® twice daily [BID] in the right eye, BromSite® once daily [QD] in the right eye, Prolensa® QD in the right eye and Ilevro™ QD in the left eye) and 7 post-dosing time points (0...
May 14, 2018: Ophthalmology and Therapy
https://www.readbyqxmd.com/read/29725860/systematic-literature-review-of-clinical-and-economic-outcomes-of-micro-invasive-glaucoma-surgery-migs-in-primary-open-angle-glaucoma
#2
REVIEW
Pavi Agrawal, Steven E Bradshaw
INTRODUCTION: Primary open-angle glaucoma is estimated to affect 3% of the population aged 40-80 years. Trabeculectomy is considered the gold standard in surgical management of glaucoma; however, it is a technically complex procedure that may result in a range of adverse outcomes. Device-augmented, minimally invasive procedures (micro-invasive glaucoma surgeries, MIGS) have been developed aiming for safer and less invasive intraocular pressure (IOP) reduction compared with traditional surgery...
May 3, 2018: Ophthalmology and Therapy
https://www.readbyqxmd.com/read/29700786/a-discussion-of-commercially-available-intra-ocular-telescopic-implants-for-patients-with-age-related-macular-degeneration
#3
REVIEW
Hannah M P Dunbar, Felipe E Dhawahir-Scala
Age-related macular degeneration (AMD) is the leading cause of visual impairment in the western world, causing significant reduction in quality of life. Despite treatment advances, the burden of visual impairment caused by AMD continues to rise. In addition to traditional low vision rehabilitation and support, optical and electronic aids, and strategies to enhance the use of peripheral vision, implantable telescopic devices have been indicated as a surgical means of enhancing vision. Here we examine the literature on commercially available telescopic devices discussing their design, mode of action, surgical procedure and published outcomes on visual acuity, quality of life, surgical complication rates and cost effectiveness data where available...
April 26, 2018: Ophthalmology and Therapy
https://www.readbyqxmd.com/read/29680880/a-phase-iii-randomized-clinical-trial-of-a-0-5-timolol-0-2-brimonidine-2-0-dorzolamide-fixed-combination-preservative-free-ophthalmic-solution-vs-0-5-timolol-0-2-brimonidine-2-0-dorzolamide-fixed-combination-in-patients-with-controlled-primary-open-angle-glaucoma
#4
Francisco Gómez-Aguayo, José A Paczka, Rubén Leñero-Córdova, Jesús Jiménez-Román, Jaime Davila-Villarreal, Curt Hartleben, Leopoldo Baiza-Durán, Oscar Olvera-Montaño, Francisco García-Velez, Patricia Muñoz-Villegas
INTRODUCTION: The aim of this prospective crossover study was to evaluate the non-inferiority of PRO-122 (a preservative-free fixed combination) compared with 0.5% timolol + 0.2% brimonidine + 2.0% dorzolamide fixed combination (KOF) by evaluating its efficacy, tolerability and safety in subjects with controlled primary open-angle glaucoma (POAG) previously treated with KOF for at least 2 months. METHODS: In a prospective, crossover, randomized, double-masked multicenter study, patients previously treated with KOF were randomly assigned to receive either PRO-122 or KOF for 30 days...
April 21, 2018: Ophthalmology and Therapy
https://www.readbyqxmd.com/read/29637411/the-correlation-between-aqueous-humor-flow-and-iop-before-and-after-trabectome-developing-a-grading-system-to-quantify-flow
#5
Toshihiko Ueda, Hirotaka Suzumura, Murray Johnstone, Shigekazu Uda, Kazuhide Yoshida
INTRODUCTION: To develop a grading system that provides objective quantification of flow through the conventional aqueous humor outflow (AHO) system. The technique gives clinicians an additional assessment option in the evaluation of glaucoma treatment approaches. METHODS: This was a retrospective observational study. This study evaluated the eyes of all primary open-angle glaucoma patients who underwent a Trabectome (NeoMedix Corp., Tustin, CA, USA) procedure with or without cataract surgery in the interval between April and September 2016 (n = 73)...
April 10, 2018: Ophthalmology and Therapy
https://www.readbyqxmd.com/read/29574676/ischemic-stroke-risk-in-medicare-beneficiaries-with-central-retinal-artery-occlusion-a-retrospective-cohort-study
#6
Dustin D French, Curtis E Margo, Paul B Greenberg
INTRODUCTION: To determine the incidence of ischemic cerebral stroke in the 6-month periods preceding and following acute central retinal artery occlusion (CRAO) among Medicare beneficiaries. METHODS: A retrospective cohort study with comparison group conducted for calendar year 2013. Patients with CRAO were identified through National Medicare limited inpatient and institutional outpatient datasets for emergency services using ICD-9-CM code for CRAO (362.31). Patients with hip fractures (ICD-9-CM 820-820...
March 24, 2018: Ophthalmology and Therapy
https://www.readbyqxmd.com/read/29536349/ultramarathon-induced-bilateral-corneal-edema-a-case-report-and-a-review-of-the-literature
#7
Majid Moshirfar, Yanning Ding, Yasmyne Ronquillo, Orry C Birdsong, Michael S Murri
Ultramarathon-associated corneal edema is a rare phenomenon. We report a case of a patient who presented with bilateral corneal edema following an ultramarathon. The corneal edema resolved without sequelae 48 h later. The authors hypothesize that the additive effect of enhanced glycolysis, an increased lactate level in the aqueous humor, and oxidative stress alters the normal endothelial regulation of the cornea and leads to corneal edema.
March 13, 2018: Ophthalmology and Therapy
https://www.readbyqxmd.com/read/29524202/a-case-report-of-conservative-management-for-a-roller-coaster-related-vitreous-haemorrhage
#8
Alexander James Brent, Abdul R El-Khayat, Shamfa A M Peart, Somnath Banerjee
The purpose of this report is to describe the case and management of an unexplained vitreous haemorrhage that occurred after repeated roller-coaster riding. The authors inadvertently demonstrate the value of observation over immediate surgery in certain situations and review the literature on vitreoretinal and other ocular complications after roller-coaster riding. A 26-year-old male presented 12 h after riding high-velocity roller-coasters with a left vitreous haemorrhage. A hazy view of the retina and B-scan revealed a bullous area of superior-temporal retinal lifting...
March 9, 2018: Ophthalmology and Therapy
https://www.readbyqxmd.com/read/29508370/aflibercept-in-diabetic-macular-oedema-previously-refractory-to-standard-intravitreal-therapy-an-irish-retrospective-study
#9
Clare F McCloskey, Ann-Marie Mongan, Shivona Chetty, Darren M J McAteer, Shauna M Quinn
INTRODUCTION: To determine visual and anatomical outcomes of diabetic macular oedema (DMO) patients in a tertiary centre following conversion to aflibercept having been refractory to previous treatment with bevacizumab/ranibizumab. METHODS: A retrospective case series of patients with a diagnosis of DMO undergoing aflibercept intravitreal therapy for at least 6 months who had previous treatment with three consecutive bevacizumab/ranibizumab injections pre-switch...
March 5, 2018: Ophthalmology and Therapy
https://www.readbyqxmd.com/read/29498015/enhanced-penetration-for-axial-length-measurement-of-eyes-with-dense-cataracts-using-swept-source-optical-coherence-tomography-a-consecutive-observational-study
#10
Nino Hirnschall, Ralph Varsits, Birgit Doeller, Oliver Findl
INTRODUCTION: The aim of this study was to find cases in which the axial eye length could not be measured with partial coherence interferometry (PCI) technology and to assess if it could be measured using swept source optical coherence tomography (ss-OCT) technology. METHODS: All patients were measured at their pre-assessment visit 1 week prior to cataract surgery using conventional optical biometry (PCI technology, IOLMaster 500, Carl Zeiss Meditec AG, Jena, Germany)...
March 1, 2018: Ophthalmology and Therapy
https://www.readbyqxmd.com/read/29442283/eplerenone-versus-observation-in-the-treatment-of-acute-central-serous-chorioretinopathy-a-retrospective-controlled-study
#11
Ilaria Zucchiatti, Riccardo Sacconi, Maria Cristina Parravano, Eliana Costanzo, Lea Querques, Daniela Montorio, Francesco Bandello, Giuseppe Querques
INTRODUCTION: To investigate the effects of eplerenone compared to observation in the treatment of acute central serous chorioretinopathy (CSC). METHODS: Charts of consecutive patients with a diagnosis of acute CSC (visual symptoms < 12 weeks) were reviewed. Included patients were divided into a treatment group (treated with eplerenone) and a control group (observation). Main outcome measures included changes in best-corrected visual acuity (BCVA), central macular thickness (CMT), height of subretinal fluid (SRF) and subfoveal choroidal thickness (CT) at 1 and 3 months in the two groups...
February 13, 2018: Ophthalmology and Therapy
https://www.readbyqxmd.com/read/29423897/the-role-of-diet-in-glaucoma-a-review-of-the-current-evidence
#12
REVIEW
Adi M Al Owaifeer, Abdulaziz A Al Taisan
Intraocular pressure (IOP) reduction by medications, laser, or surgery remains the mainstay of treatment in glaucoma. However, the role of complementary and alternative medicine (CAM) in glaucoma has received great interest from both patients and ophthalmologists. Previous evidence suggests that diet, a major domain of CAM, can influence an individual's IOP level. Furthermore, certain dietary components have been linked to the incidence and progression of glaucoma. In this review, we aim to provide a summary of the current evidence regarding the role of obesity, certain dietary components, and dietary supplements in glaucoma...
February 8, 2018: Ophthalmology and Therapy
https://www.readbyqxmd.com/read/29383674/choriocapillaris-vascular-density-changes-in-patients-with-drusen-cross-sectional-study-based-on-optical-coherence-tomography-angiography-findings
#13
Irini Chatziralli, George Theodossiadis, Dimitrios Panagiotidis, Paraskevi Pousoulidi, Panagiotis Theodossiadis
INTRODUCTION: The purpose of this study was to investigate the extent and morphology of the choriocapillaris' density defect in patients with drusen in non-neovascular age-related macular degeneration (AMD). METHODS: Participants in this study were 36 patients with non-neovascular AMD and drusen. All patients underwent best-corrected visual acuity, slit-lamp examination, spectral domain-optical coherence tomography (SD-OCT), and optical coherence tomography angiography (OCTA)...
January 30, 2018: Ophthalmology and Therapy
https://www.readbyqxmd.com/read/29305763/case-report-scleral-metastasis-of-esophageal-squamous-cell-carcinoma
#14
Rahim Mahmodlou, Fahimeh Asadi Amoli, Ata Abbasi, Seyed Arman Seyed Mokhtari, Sajjad Pourasghary
In this report, a case of ocular scleral metastasis was reported in a patient with a past history of esophageal squamous cell carcinoma. The patient was a 58-year-old male who was admitted to Urmia Imam Khomeini Hospital, Urmia, Iran, 8 years ago with progressive dysphasia. Seven years after initial diagnosis and treatment of esophageal cancer, the patient had no signs or symptoms of the disease. But 2 months ago, he was referred to the hospital due to ocular swelling, redness and watering. Pathologic examination of the excised lesion at Farabi Hospital reported metastasis of squamous cell carcinoma to the connective tissue of the sclera...
January 5, 2018: Ophthalmology and Therapy
https://www.readbyqxmd.com/read/29275457/clinical-outcomes-after-keraring-implantation-for-keratoconus-management-in-patients-older-than-40-years-a-retrospective-interventional-cohort-study
#15
Zisis Gatzioufas, Aye Khine, Mohamed Elalfy, Ivo Guber, Cameron McLintock, Francesco Sabatino, Samer Hamada, Damian Lake
BACKGROUND: Intracorneal ring segment implantation is an effective and safe method of visual improvement in patients with keratoconus. The aim of our study was to evaluate the long-term clinical outcomes after Keraring implantation for keratoconus in patients older than 40 years. METHODS: Eleven eyes from 11 patients with keratoconus who underwent femtosecond laser-assisted Keraring implantation for keratoconus were included in this retrospective study. The uncorrected visual acuity (UCVA), corrected visual acuity, keratometric readings, central corneal thickness and thinnest corneal pachymetry were evaluated preoperatively and 6 months after the Keraring implantation...
December 23, 2017: Ophthalmology and Therapy
https://www.readbyqxmd.com/read/29236212/post-operative-refractive-prediction-error-after-phacovitrectomy-a-retrospective-study
#16
Gijsbert J Hötte, Daniël P de Bruyn, Joeri de Hoog
INTRODUCTION: Many authors have reported on a myopic post-operative refractive prediction error when combining phacoemulsification with pars plana vitrectomy (phacovitrectomy). In this study we evaluate the amount of this error in our facility and try to elucidate the various factors involved. METHODS: This was a retrospective study which included 140 patients who underwent phacovitrectomy (39 with macular holes, 88 with puckers, and 13 with floaters). Post-operative refractive error was defined as the difference between the actual spherical equivalent (SEQ) and expected SEQ based on the SRK/T and Holladay-II formulas...
December 13, 2017: Ophthalmology and Therapy
https://www.readbyqxmd.com/read/29086187/comparative-results-in-a-combined-procedure-of-intrastromal-corneal-rings-implantation-and-cross-linking-in-patients-with-keratoconus-a-retrospective-study
#17
Cristina Nicula, Radu Nicolae Pop, Dorin V Nicula
INTRODUCTION: Corneal thinning disorders caused by keratoconus often lead to protrusion, irregular astigmatism, and even perforation. Keratoconus, like other corneal ectasia, does not have a known cause. Severe cases of keratoconus may require correction or restoration of tectonic integrity of the cornea by surgical means. Intracorneal ring segments are a new modality in the treatment of corneal ectactic disorders. A new technique of stopping the evolution of keratoconus and strengthening the cornea is combining techniques of intrastromal corneal ring implantation and corneal collagen cross-linking...
December 2017: Ophthalmology and Therapy
https://www.readbyqxmd.com/read/29043565/eccentric-macular-hole-after-pars-plana-vitrectomy-for-epiretinal-membrane-without-internal-limiting-membrane-peeling-a-case-report
#18
Christina Garnavou-Xirou, Tina Xirou, Stamatina Kabanarou, Ilias Gkizis, Stavros Velissaris, Irini Chatziralli
INTRODUCTION: Postoperative eccentric macular hole formation is an uncommon complication after pars plana vitrectomy (PPV) without internal limiting membrane (ILM) peeling for the treatment of epiretinal membrane (ERM). We present a case of eccentric macular hole formation after PPV for ERM without ILM peeling. CASE REPORT: A 68-year-old male patient presented with ERM and visual acuity of 6/24 in his left eye. He underwent 23-gauge PPV without ILM peeling for treatment of ERM...
December 2017: Ophthalmology and Therapy
https://www.readbyqxmd.com/read/29022285/macular-hole-development-after-vitrectomy-for-floaters-a-case-report
#19
Andrea Appeltans, Marco Mura, Giulio Bamonte
INTRODUCTION: The purpose of this report is to describe a case of macular hole development after vitrectomy for floaters with induction of posterior vitreous detachment. CASE REPORT: A 44-year-old otherwise healthy man presented with visually debilitating floaters in his right eye; these had been present for more than 2 years. Preoperative examination was unremarkable in both eyes, apart from some degree of vitreous degeneration in the right eye. Preoperative visual acuity was 20/20 bilaterally...
December 2017: Ophthalmology and Therapy
https://www.readbyqxmd.com/read/28956287/use-of-the-controlled-adverse-environment-cae-in-clinical-research-a-review
#20
REVIEW
George W Ousler, David Rimmer, Lisa M Smith, Mark B Abelson
The many internal and external factors that contribute to the pathophysiology of dry eye disease (DED) create a difficult milieu for its study and complicate its clinical diagnosis and treatment. The controlled adverse environment (CAE® ) model has been developed to minimize the variability that arises from exogenous factors and to exacerbate the signs and symptoms of DED by stressing the ocular surface in a safe, standardized, controlled, and reproducible manner. By integrating sensitive, specific, and clinically relevant endpoints, the CAE has proven to be a unique and adaptable model for both identifying study-specific patient populations with modifiable signs and symptoms, and for tailoring the evaluation of interventions in clinical research studies...
December 2017: Ophthalmology and Therapy
journal
journal
48937
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"