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Cardiology and Therapy

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https://www.readbyqxmd.com/read/28623549/elevated-circulating-pcsk9-concentrations-predict-subclinical-atherosclerotic-changes-in-low-risk-obese-and-non-obese-patients
#1
Štefan Tóth, Ján Fedačko, Tímea Pekárová, Zdenka Hertelyová, Matan Katz, Adil Mughees, Jozef Kuzma, Peter Štefanič, Ivan Kopolovets, Daniel Pella
INTRODUCTION: Many studies have highlighted the important role of PCSK9 in the development of cardiometabolic changes and its possible function as a biomarker of myocardial infarction or ischemic heart disease. This study aimed to determine the relationship between circulating PCSK9 levels and subclinical vascular changes in the group of low risk patients without manifest cardiovascular diseases. METHODS: In this study, 120 healthy patients, free of manifest cardiovascular diseases, diabetes mellitus, and without lipid-lowering therapy, were divided into three groups based on BMI: normal weight (N = 50), overweight (N = 30), and obese (N = 40)...
June 16, 2017: Cardiology and Therapy
https://www.readbyqxmd.com/read/28616861/medical-therapy-and-recurrent-ischemic-events-in-high-risk-patients-surviving-their-myocardial-infarction-for-at-least-12%C3%A2-months-comparison-of-patients-with-st-elevation-versus-non-st-elevation-myocardial-infarction
#2
Uwe Zeymer, Katrin Riedel, Michael Hahn
INTRODUCTION: Data about treatments and recurrent ischemic events in patients surviving their most recent myocardial infarction event-free for at least 12 months are scarce. METHODS: In a retrospective data analysis, charts of patients who had a myocardial infarction 1-3 years ago with an event-free period of at least 12 months after the index event and at least one high risk factor were centrally collected and analyzed. Here we compare patients with ST elevation myocardial infarction (STEMI) versus non-ST elevation myocardial infarction (NSTEMI)...
June 14, 2017: Cardiology and Therapy
https://www.readbyqxmd.com/read/28526929/analytical-management-of-patients-undergoing-oral-anticoagulant-therapy-could-have-a-strong-impact-on-clinical-outcomes-a-follow-up-study
#3
Vincenzo De Iuliis, Sebastiano Ursi, Gianfranco Vitullo, Irma Griffo, Antonio Marino, Marika Caruso, Francesco Cipollone, Sabrina Capodifoglio, Veronica Breda, Elena Toniato, Alfonso Pennelli, Pio Conti, Stefano Martinotti
INTRODUCTION: Oral anticoagulant therapy, such as vitamin K antagonists (VKAs), is prominent for the prevention of cerebral ischemic stroke or systemic embolism and all-cause mortality in patients with atrial fibrillation, venous thromboembolism, and mechanical or biological valve. VKA treatment requires monitoring of the international normalized ratio (INR) in order to maintain it in a therapeutic range, avoiding side effects, the main and most significant of which is bleeding. The aim of the present study was to evaluate the event rates of several clinical composite outcomes, such as bleeding, thromboembolic events, and all-cause death...
May 19, 2017: Cardiology and Therapy
https://www.readbyqxmd.com/read/28526928/exosomes-in-cardiovascular-medicine
#4
REVIEW
Iain M Dykes
Exosomes are small, extracellular membrane-bound particles that mediate intercellular transport of a cytosolic cargo. Exosomal transfer of micro-RNA can modify gene expression in targeted cells. Exosome-based endocrine/paracrine signaling has been shown to be involved in a wide range of physiological processes including those associated with cardiovascular injury and disease, but remains relatively poorly understood. Exosomes offer great potential to the clinical field, with applications in both diagnostics and therapeutics...
May 19, 2017: Cardiology and Therapy
https://www.readbyqxmd.com/read/28357773/centralized-pan-middle-east-survey-on-the-under-treatment-of-hypercholesterolemia-results-from-the-cepheus-ii-study-in-egypt
#5
Ashraf Reda, Alaa Etman, Ali Abdel-Rahim, Nabil Farag, Osama Sanad, Sameh Salamah
INTRODUCTION: As part of the CEPHEUS study, CEPHEUS I was conducted in 2010 and 2011 in Cairo and then the CEPHEUS II study was carried out in Alexandria and Delta Regions in Egypt between April 2014 and August 2015 to determine the proportion of dyslipidemic patients on lipid-lowering treatment reaching LDL-C treatment goals. METHODS: We conducted an open-label, observational, multicenter, cross-sectional survey where 90 investigators enrolled 1127 patients receiving lipid-lowering drugs for at least 3 months...
June 2017: Cardiology and Therapy
https://www.readbyqxmd.com/read/28353137/high-risk-trans-catheter-aortic-valve-replacement-in-a-failed-freestyle-valve-with-low-coronary-height-a-case-report
#6
Ashkan Karimi, Negiin Pourafshar, George Dibu, Thomas M Beaver, Anthony A Bavry
A 55-year-old male with a history of two prior cardiac surgeries presented with decompensated heart failure due to severe bioprosthetic aortic valve insufficiency. A third operation was viewed prohibitively high risk and valve-in-valve trans-catheter aortic valve replacement was considered. There were however several high-risk features and technically challenging aspects including low coronary ostia height, poor visualization of the aortic sinuses, and difficulty in identification of the coplanar view due to severe aortic insufficiency, and a highly mobile aortic valve mass...
June 2017: Cardiology and Therapy
https://www.readbyqxmd.com/read/28258390/management-of-hypertension-using-olmesartan-alone-or-in-combination
#7
REVIEW
Xiaoshen Zhang, Han Zhang, Yuxia Ma, Wenliang Che, Michael R Hamblin
Hypertension is one of the most significant and consistent risk factors for many cardiovascular diseases. The global prevalence of hypertension has dramatically increased over recent years. Life-style and genetic factors are generally considered to be primarily responsible for the incidence of hypertension. Concerning the high morbidity rate, setting up an updated standard for hypertensive patients becomes indispensable. According to the widely accepted standard treatments for hypertension, these four basic principles should be taken into account: low dosage; medication should provide long term-control; combination therapies are becoming common; personalized treatments are a newer approach...
June 2017: Cardiology and Therapy
https://www.readbyqxmd.com/read/28258389/inappropriate-icd-discharge-related-to-electrical-muscle-stimulation-in-chiropractic-therapy-a-case-report
#8
Abhishek Shenoy, Abhishek Sharma, Firehiwot Achamyeleh
Implantable cardioverter defibrillators (ICDs) have been shown to reduce mortality in high-risk patients. Despite several advances in programming ICDs, inappropriate shocks persist and continue to be psychologically and physically disturbing. External electromagnetic interference from electrocautery, welding, acupunctures, low-output transcutaneous electric nerve stimulators, and electronic muscle stimulators may result in inappropriate ICD sensing and shock. We present a 63-year-old female who presented to the emergency department after an ICD shock while undergoing electronic muscle stimulation in chiropractic treatment, during which light electrical pulses were sent through skin electrodes...
June 2017: Cardiology and Therapy
https://www.readbyqxmd.com/read/28181192/single-pill-combination-of-perindopril-indapamide-amlodipine-in-patients-with-uncontrolled-hypertension-a-randomized-controlled-trial
#9
Sergey V Nedogoda, Vesna J Stojanov
INTRODUCTION: Patients with hypertension often require a combination of three antihypertensive agents to achieve blood pressure control, but very few single-pill triple combinations are available. The aim of this study was to determine whether a single-pill triple combination of perindopril, indapamide, and amlodipine was as effective as a dual-pill combination of perindopril/indapamide plus separate amlodipine at reducing blood pressure in patients with uncontrolled, essential hypertension...
June 2017: Cardiology and Therapy
https://www.readbyqxmd.com/read/28124310/subclinical-right-ventricular-dysfunction-in-patients-with-severe-aortic-stenosis-a-retrospective-case-series
#10
Dagmar F Hernandez-Suarez, Angel López-Candales
INTRODUCTION: There is scarce information about right ventricle (RV) function in patients with secondary pulmonary hypertension (PH) undergoing transcatheter aortic valve implantation (TAVI). We aim to identify possible RV abnormalities in patients referred for TAVI with severe aortic stenosis (sAS) and secondary PH. METHODS: Objective measures of RV function, as well as noninvasive estimates of pulmonary artery systolic pressures (PASP) were obtained from 30 sAS patients undergoing percutaneous valve intervention...
June 2017: Cardiology and Therapy
https://www.readbyqxmd.com/read/28105561/the-rise-and-fall-of-anticoagulation-with-bivalirudin-during-percutaneous-coronary-interventions-a-review-article
#11
REVIEW
Constantinos Andreou, Christos Maniotis, Michael Koutouzis
Bivalirudin is a direct thrombin inhibitor used during percutaneous coronary intervention (PCI). Treatment with bivalirudin compared to heparin plus glycoprotein IIb/IIIa inhibitors (GPI) reduced bleeding complications, but resulted in higher rates of ischemic events, including acute stent thrombosis in ST segment elevation myocardial infarction (STEMI) patients. Thus, it may be considered a reasonable alternative antithrombotic agent in patients at high risk of bleeding undergoing PCI. However its superiority over heparin alone is questioned particularly in the era of novel antiplatelet agents and transradial PCI...
June 2017: Cardiology and Therapy
https://www.readbyqxmd.com/read/28105560/erratum-to-improvement-of-subjective-well-being-by-ranolazine-in-patients-with-chronic-angina-and-known-myocardial-ischemia-imwell-study
#12
Anthony A Bavry, Ki E Park, Calvin Y Choi, Ahmed N Mahmoud, Xuerong Wen, Islam Y Elgendy
No abstract text is available yet for this article.
June 2017: Cardiology and Therapy
https://www.readbyqxmd.com/read/28044267/late-paravalvular-aortic-regurgitation-migration-of-the-valve-or-late-recoil
#13
Ashkan Karimi, Negiin Pourafshar, Ki E Park, Calvin Y Choi, Kiran Mogali, Wade W Stinson, Eddie W Manning, Anthony A Bavry
A 79-year-old man underwent trans-catheter aortic valve replacement for symptomatic severe aortic stenosis with a 26-mm Edwards SAPIEN XT valve. Immediately after valve deployment there was moderate amount of paravalvular leak. Post-dilation was performed with an additional 2 cc of volume, and the paravalvular leak was reduced to trace. Nine months later, trans-thoracic echocardiography revealed moderate to severe paravalvular leak and possible aortic migration of the valve. The patient was brought back for the treatment of the paravalvular leak which was suspected to be due to valve migration...
June 2017: Cardiology and Therapy
https://www.readbyqxmd.com/read/28044266/a-comparative-effectiveness-study-of-renal-parameters-between-imidapril-and-amlodipine-in-patients-with-hypertension-a-retrospective-cohort-study
#14
Yayoi Nishida, Yasuo Takahashi, Kotoe Tezuka, Satoshi Takeuchi, Tomohiro Nakayama, Satoshi Asai
INTRODUCTION: Imidapril is an angiotensin converting enzyme inhibitor (ACEI) that is frequently used as an antihypertensive drug in Japan. Although ACEIs are known to have adverse effects of decreasing glomerular filtration rate (GFR) and causing hyperkalemia, there are very few clinical data on the long-term effect of imidapril on glomerular function. We conducted a retrospective cohort study using a clinical database to evaluate and compare the long-term effects of imidapril and amlodipine on renal parameters in Japanese hypertensive patients in routine clinical practice...
June 2017: Cardiology and Therapy
https://www.readbyqxmd.com/read/28044265/improvement-of-subjective-well-being-by-ranolazine-in-patients-with-chronic-angina-and-known-myocardial-ischemia-imwell-study
#15
Anthony A Bavry, Ki E Park, Calvin Y Choi, Ahmed N Mahmoud, Xuerong Wen, Islam Y Elgendy
INTRODUCTION: We aimed to assess if ranolazine would improve angina symptoms among patients with documented myocardial ischemia. METHODS: Eligible subjects had chronic stable angina and at least one coronary stenosis with fractional flow reserve (FFR) ≤0.80 or at least one chronic total occlusion (CTO) without attempted revascularization. Subjects were randomized to oral ranolazine 500 mg twice daily for 1 week, then ranolazine 1000 mg twice daily for 15 weeks versus matching placebo...
June 2017: Cardiology and Therapy
https://www.readbyqxmd.com/read/28035630/knowledge-of-hypertension-and-compliance-with-therapy-among-hypertensive-patients-in-the-bamenda-health-district-of-cameroon-a-cross-sectional-study
#16
Bentley Mbekwa Akoko, Peter Nde Fon, Roland Cheofor Ngu, Kathleen Blackett Ngu
INTRODUCTION: The prevalence of hypertension has continued to increase and is now a great burden for health care providers. Obtaining information on the factors affecting compliance to antihypertensive drugs is thus important. The aim of this study was to assess knowledge of hypertension and to determine factors affecting the compliance of hypertensive patients to their antihypertensive drugs. METHODS: This was a cross-sectional study involving 221 hypertensive patients in the Bamenda Health District...
June 2017: Cardiology and Therapy
https://www.readbyqxmd.com/read/27995554/a-randomized-trial-to-assess-the-contribution-of-a-novel-thorax-support-vest-corset-in-preventing-mechanical-complications-of-median-sternotomy
#17
Philippe P Caimmi, Maurizio Sabbatini, Emmanouil I Kapetanakis, Silvia Cantone, Marcus V Ferraz, Mario Cannas, Ugo F Tesler
OBJECTIVES: Mechanical complications of median sternotomy may cause significant morbidity and mortality in cardiac surgical patients. This study was aimed at assessing the role of Posthorax support vest (Epple, Inc., Vienna, Austria) in the prevention of sternal complications and the improvement of anatomical healing in patients at high risk for mechanical sternal dehiscence after cardiac surgery by mean of median sternotomy. METHODS: A prospective, randomized, study was performed and 310 patients with predisposing factors for sternal dehiscence after sternotomy for cardiac surgery were included...
June 2017: Cardiology and Therapy
https://www.readbyqxmd.com/read/27981491/cardiovascular-abnormalities-and-in-hospital-all-cause-mortality-in-patients-with-spontaneous-sub-arachnoid-hemorrhage-an-observational-study
#18
Ahmed N Mahmoud, Akram Y Elgendy, Hend Mansoor, Islam Y Elgendy
INTRODUCTION: Patients with spontaneous sub-arachnoid hemorrhage (SAH) might develop various cardiac abnormalities, however; the prognostic implications of these cardiac abnormalities are not well known. This study aimed to detect the cardiac abnormality that correlates best with in-hospital all-cause mortality in patients with SAH. METHODS: In this retrospective study, all patients admitted to our institution with a primary diagnosis of SAH, and underwent a transthoracic echocardiogram (TTE) from July 2011 until May 2014, were enrolled...
June 2017: Cardiology and Therapy
https://www.readbyqxmd.com/read/27896705/does-gender-influence-the-cardiovascular-benefits-observed-with-sodium-glucose-co-transporter-2-sglt-2-inhibitors-a-meta-regression-analysis
#19
Ahmed N Mahmoud, Islam Y Elgendy, Marwan Saad, Akram Y Elgendy, Amr F Barakat, Amgad Mentias, Ahmed Abuzaid, Anthony A Bavry
INTRODUCTION: Although a large recent trial had shown improved cardiovascular outcomes of diabetic patients on sodium glucose co-transporter-2 (SGLT-2) inhibitors, the influence of gender differences on such outcomes is not known. Thus, we aimed to assess the impact of gender on such outcomes in the patients with type 2 diabetes mellitus receiving SGLT-2 inhibitors. METHODS: A search of electronic databases was conducted for all randomized trials comparing SGLT-2 inhibitors with placebo in patients with diabetes mellitus...
June 2017: Cardiology and Therapy
https://www.readbyqxmd.com/read/27888501/infective-endocarditis-how-do-we-currently-interpret-the-duke-minor-criterion-predisposing-heart-condition-in-native-valves
#20
Annina Elisabeth Büchi, Mario Hoffmann, Stephan Zbinden, Parham Sendi
INTRODUCTION: The term "predisposing heart condition" is used as an indication of antimicrobial prophylaxis to prevent infective endocarditis (IE) and as a criterion for diagnosing IE according to modified Duke criteria. The purpose of this survey was to elaborate clinician's knowledge and opinion on relevant heart conditions as a Duke minor criterion for the diagnosis of IE. METHODS: A questionnaire was created that consisted of two knowledge and two opinion questions on the term predisposing heart condition...
June 2017: Cardiology and Therapy
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