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Frontiers in Bioengineering and Biotechnology

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https://www.readbyqxmd.com/read/28224123/model-based-pat-for-quality-management-in-pharmaceuticals-freeze-drying-state-of-the-art
#1
REVIEW
Davide Fissore
Model-based process analytical technologies can be used for the in-line control and optimization of a pharmaceuticals freeze-drying process, as well as for the off-line design of the process, i.e., the identification of the optimal operating conditions. This paper aims at presenting the state of the art in this field, focusing, particularly, on three groups of systems, namely, those based on the temperature measurement (i.e., the soft sensor), on the chamber pressure measurement (i.e., the systems based on the test of pressure rise and of pressure decrease), and on the sublimation flux estimate (i...
2017: Frontiers in Bioengineering and Biotechnology
https://www.readbyqxmd.com/read/28220147/robustness-of-frequency-division-technique-for-online-myoelectric-pattern-recognition-against-contraction-level-variation
#2
Bahareh Tolooshams, Ning Jiang
Contraction-level invariant surface electromyography pattern recognition introduces the decrease of training time and decreases the limitation of clinical prostheses. This study intended to examine whether a signal pre-processing method named frequency division technique (FDT) for online myoelectric pattern recognition classification is robust against contraction-level variation, and whether this pre-processing method has an advantage over traditional time-domain pattern recognition techniques even in the absence of muscle contraction-level variation...
2017: Frontiers in Bioengineering and Biotechnology
https://www.readbyqxmd.com/read/28164082/semiautomated-3d-spine-reconstruction-from-biplanar-radiographic-images-prediction-of-intervertebral-loading-in-scoliotic-subjects
#3
Tito Bassani, Claudia Ottardi, Francesco Costa, Marco Brayda-Bruno, Hans-Joachim Wilke, Fabio Galbusera
The present study proposes a semiautomatic software approach to reconstruct 3D subject-specific musculoskeletal model of thoracolumbar spine from radiographic digitized images acquired with EOS system. The approach is applied to evaluate the intervertebral loads in 38 standing adolescents with mild idiopathic scoliosis. For each vertebra, a set of landmarks was manually identified on radiographic images. The landmark coordinates were processed to calculate the following vertebral geometrical properties in the 3D space (i) location (ii) dimensions; and (iii) rotations...
2017: Frontiers in Bioengineering and Biotechnology
https://www.readbyqxmd.com/read/28180128/usability-evaluation-of-a-vibrotactile-feedback-system-in-stroke-subjects
#4
Jeremia P Held, Bart Klaassen, Bert-Jan F van Beijnum, Andreas R Luft, Peter H Veltink
BACKGROUND: To increase the functional capabilities of stroke subjects during activities of daily living, patients receive rehabilitative training to recover adequate motor control. With the goal to motivate self-training by use of the arm in daily life tasks, a sensor system (Arm Usage Coach, AUC) was developed that provides VibroTactile (VT) feedback if the patient does not move the affected arm above a certain threshold level. The objective of this study is to investigate the usability of this system in stroke subjects...
2016: Frontiers in Bioengineering and Biotechnology
https://www.readbyqxmd.com/read/28168187/an-efficient-electroporation-protocol-for-the-genetic-modification-of-mammalian-cells
#5
Leonardo Chicaybam, Camila Barcelos, Barbara Peixoto, Mayra Carneiro, Cintia Gomez Limia, Patrícia Redondo, Carla Lira, Flávio Paraguassú-Braga, Zilton Farias Meira De Vasconcelos, Luciana Barros, Martin Hernán Bonamino
Genetic modification of cell lines and primary cells is an expensive and cumbersome approach, often involving the use of viral vectors. Electroporation using square-wave generating devices, like Lonza's Nucleofector, is a widely used option, but the costs associated with the acquisition of electroporation kits and the transient transgene expression might hamper the utility of this methodology. In the present work, we show that our in-house developed buffers, termed Chicabuffers, can be efficiently used to electroporate cell lines and primary cells from murine and human origin...
2016: Frontiers in Bioengineering and Biotechnology
https://www.readbyqxmd.com/read/28144611/the-chlorella-vulgaris-s-nitrosoproteome-under-nitrogen-replete-and-deplete-conditions
#6
Calvin A Henard, Michael T Guarnieri, Eric P Knoshaug
No abstract text is available yet for this article.
2016: Frontiers in Bioengineering and Biotechnology
https://www.readbyqxmd.com/read/28083531/pulse-shape-and-timing-dependence-on-the-spike-timing-dependent-plasticity-response-of-ion-conducting-memristors-as-synapses
#7
Kristy A Campbell, Kolton T Drake, Elisa H Barney Smith
Ion-conducting memristors comprised of the layered materials Ge2Se3/SnSe/Ag are promising candidates for neuromorphic computing applications. Here, the spike-timing dependent plasticity (STDP) application is demonstrated for the first time with a single memristor type operating as a synapse over a timescale of 10 orders of magnitude, from nanoseconds through seconds. This large dynamic range allows the memristors to be useful in applications that require slow biological times, as well as fast times such as needed in neuromorphic computing, thus allowing multiple functions in one design for one memristor type-a "one size fits all" approach...
2016: Frontiers in Bioengineering and Biotechnology
https://www.readbyqxmd.com/read/28083530/toward-multiscale-models-of-cyanobacterial-growth-a-modular-approach
#8
REVIEW
Stefanie Westermark, Ralf Steuer
Oxygenic photosynthesis dominates global primary productivity ever since its evolution more than three billion years ago. While many aspects of phototrophic growth are well understood, it remains a considerable challenge to elucidate the manifold dependencies and interconnections between the diverse cellular processes that together facilitate the synthesis of new cells. Phototrophic growth involves the coordinated action of several layers of cellular functioning, ranging from the photosynthetic light reactions and the electron transport chain, to carbon-concentrating mechanisms and the assimilation of inorganic carbon...
2016: Frontiers in Bioengineering and Biotechnology
https://www.readbyqxmd.com/read/28066763/optimization-and-characterization-of-the-synthetic-secondary-chromosome-synvicii-in-escherichia-coli
#9
Sonja J Messerschmidt, Daniel Schindler, Celine M Zumkeller, Franziska S Kemter, Nadine Schallopp, Torsten Waldminghaus
Learning by building is one of the core ideas of synthetic biology research. Consequently, building synthetic chromosomes is the way to fully understand chromosome characteristics. The last years have seen exciting synthetic chromosome studies. We had previously introduced the synthetic secondary chromosome synVicII in Escherichia coli. It is based on the replication mechanism of the secondary chromosome in Vibrio cholerae. Here, we present a detailed analysis of its genetic characteristics and a selection approach to optimize replicon stability...
2016: Frontiers in Bioengineering and Biotechnology
https://www.readbyqxmd.com/read/28066762/assessment-of-novel-routes-of-biomethane-utilization-in-a-life-cycle-perspective
#10
Elham Ahmadi Moghaddam, Serina Ahlgren, Åke Nordberg
Biomethane, as a replacement for natural gas, reduces the use of fossil-based sources and supports the intended change from fossil to bio-based industry. The study assessed different biomethane utilization routes for production of methanol, dimethyl ether (DME), and ammonia, as fuel or platform chemicals and combined heat and power (CHP). Energy efficiency and environmental impacts of the different pathways was studied in a life cycle perspective covering the technical system from biomass production to the end product...
2016: Frontiers in Bioengineering and Biotechnology
https://www.readbyqxmd.com/read/27999773/in-vitro-evaluation-of-biocompatibility-of-uncoated-thermally-reduced-graphene-and-carbon-nanotube-loaded-pvdf-membranes-with-adult-neural-stem-cell-derived-neurons-and-glia
#11
Çağla Defteralı, Raquel Verdejo, Shahid Majeed, Adriana Boschetti-de-Fierro, Héctor R Méndez-Gómez, Eva Díaz-Guerra, Daniel Fierro, Kristian Buhr, Clarissa Abetz, Ricardo Martínez-Murillo, Daniela Vuluga, Michaël Alexandre, Jean-Michel Thomassin, Christophe Detrembleur, Christine Jérôme, Volker Abetz, Miguel Ángel López-Manchado, Carlos Vicario-Abejón
Graphene, graphene-based nanomaterials (GBNs), and carbon nanotubes (CNTs) are being investigated as potential substrates for the growth of neural cells. However, in most in vitro studies, the cells were seeded on these materials coated with various proteins implying that the observed effects on the cells could not solely be attributed to the GBN and CNT properties. Here, we studied the biocompatibility of uncoated thermally reduced graphene (TRG) and poly(vinylidene fluoride) (PVDF) membranes loaded with multi-walled CNTs (MWCNTs) using neural stem cells isolated from the adult mouse olfactory bulb (termed aOBSCs)...
2016: Frontiers in Bioengineering and Biotechnology
https://www.readbyqxmd.com/read/27995126/discriminability-of-single-and-multichannel-intracortical-microstimulation-within-somatosensory-cortex
#12
Cynthia K Overstreet, Randall B Hellman, Ruben D Ponce Wong, Veronica J Santos, Stephen I Helms Tillery
The addition of tactile and proprioceptive feedback to neuroprosthetic limbs is expected to significantly improve the control of these devices. Intracortical microstimulation (ICMS) of somatosensory cortex is a promising method of delivering this sensory feedback. To date, the main focus of somatosensory ICMS studies has been to deliver discriminable signals, corresponding to varying intensity, to a single location in cortex. However, multiple independent and simultaneous streams of sensory information will need to be encoded by ICMS to provide functionally relevant feedback for a neuroprosthetic limb (e...
2016: Frontiers in Bioengineering and Biotechnology
https://www.readbyqxmd.com/read/27990418/finite-element-study-of-a-lumbar-intervertebral-disc-nucleus-replacement-device
#13
Jessica S Coogan, W Loren Francis, Travis D Eliason, Todd L Bredbenner, Brian D Stemper, Narayan Yoganandan, Frank A Pintar, Daniel P Nicolella
Nucleus replacement technologies are a minimally invasive alternative to spinal fusion and total disc replacement that have the potential to reduce pain and restore motion for patients with degenerative disc disease. Finite element modeling can be used to determine the biomechanics associated with nucleus replacement technologies. The current study focuses on a new nucleus replacement device designed as a conforming silicone implant with an internal void. A validated finite element model of the human lumbar L3-L4 motion segment was developed and used to investigate the influence of the nucleus replacement device on spine biomechanics...
2016: Frontiers in Bioengineering and Biotechnology
https://www.readbyqxmd.com/read/27965954/potential-of-an-exploitation-of-acid-tolerant-antimicrobial-microorganisms-evolving-enzyme-systems-for-the-utilization-of-dairy-by-products-and-lignocellulosic-biomass-to-lactic-acid
#14
Grazina Juodeikiene, Daiva Zadeike, Elena Bartkiene, Vadims Bartkevics, Alexander Dikiy, Elena Shumilina
No abstract text is available yet for this article.
2016: Frontiers in Bioengineering and Biotechnology
https://www.readbyqxmd.com/read/27965953/metabolic-engineering-of-pseudomonas-putida-kt2440-for-the-production-of-para-hydroxy-benzoic-acid
#15
Shiqin Yu, Manuel R Plan, Gal Winter, Jens O Krömer
para-Hydroxy benzoic acid (PHBA) is the key component for preparing parabens, a common preservatives in food, drugs, and personal care products, as well as high-performance bioplastics such as liquid crystal polymers. Pseudomonas putida KT2440 was engineered to produce PHBA from glucose via the shikimate pathway intermediate chorismate. To obtain the PHBA production strain, chorismate lyase UbiC from Escherichia coli and a feedback resistant 3-deoxy-d-arabino-heptulosonate-7-phosphate synthase encoded by gene aroG(D146N) were overexpressed individually and simultaneously...
2016: Frontiers in Bioengineering and Biotechnology
https://www.readbyqxmd.com/read/27933290/validation-of-a-cochlear-implant-patient-specific-model-of-the-voltage-distribution-in-a-clinical-setting
#16
Waldo Nogueira, Daniel Schurzig, Andreas Büchner, Richard T Penninger, Waldemar Würfel
Cochlear Implants (CIs) are medical implantable devices that can restore the sense of hearing in people with profound hearing loss. Clinical trials assessing speech intelligibility in CI users have found large intersubject variability. One possibility to explain the variability is the individual differences in the interface created between electrodes of the CI and the auditory nerve. In order to understand the variability, models of the voltage distribution of the electrically stimulated cochlea may be useful...
2016: Frontiers in Bioengineering and Biotechnology
https://www.readbyqxmd.com/read/27917380/effect-of-dynamic-temperature-stimulus-to-plantar-surface-of-the-foot-in-the-standing-position
#17
Ryo Watanabe, Hiroyuki Kajimoto
We have previously found that a vertical force or tactile sensation occurs when the temperature of a participant's skin changes rapidly. In this illusion, upward motion, pressure, or force sensation is elicited when stimulus temperature rises rapidly, whereas in the opposite case, downward motion or pulling sensation is elicited. In this paper, we applied this phenomenon to the sole (plantar surface of the foot) to present the sensation of ground slope. To investigate this, we conducted an experiment that measured the correlation between stimulation temperature and front-back direction position of the center of gravity...
2016: Frontiers in Bioengineering and Biotechnology
https://www.readbyqxmd.com/read/27896266/in-vitro-bone-cell-models-impact-of-fluid-shear-stress-on-bone-formation
#18
REVIEW
Claudia Wittkowske, Gwendolen C Reilly, Damien Lacroix, Cecile M Perrault
This review describes the role of bone cells and their surrounding matrix in maintaining bone strength through the process of bone remodeling. Subsequently, this work focusses on how bone formation is guided by mechanical forces and fluid shear stress in particular. It has been demonstrated that mechanical stimulation is an important regulator of bone metabolism. Shear stress generated by interstitial fluid flow in the lacunar-canalicular network influences maintenance and healing of bone tissue. Fluid flow is primarily caused by compressive loading of bone as a result of physical activity...
2016: Frontiers in Bioengineering and Biotechnology
https://www.readbyqxmd.com/read/27872840/analysis-of-uncertainty-and-variability-in-finite-element-computational-models-for-biomedical-engineering-characterization-and-propagation
#19
REVIEW
Nerea Mangado, Gemma Piella, Jérôme Noailly, Jordi Pons-Prats, Miguel Ángel González Ballester
Computational modeling has become a powerful tool in biomedical engineering thanks to its potential to simulate coupled systems. However, real parameters are usually not accurately known, and variability is inherent in living organisms. To cope with this, probabilistic tools, statistical analysis and stochastic approaches have been used. This article aims to review the analysis of uncertainty and variability in the context of finite element modeling in biomedical engineering. Characterization techniques and propagation methods are presented, as well as examples of their applications in biomedical finite element simulations...
2016: Frontiers in Bioengineering and Biotechnology
https://www.readbyqxmd.com/read/27867934/a-comparison-of-molecular-biology-mechanism-of-shewanella-putrefaciens-between-fresh-and-terrestrial-sewage-wastewater
#20
Jiajie Xu, Weina He, Zhonghua Wang, Dijun Zhang, Jing Sun, Jun Zhou, Yanyan Li, Xiurong Su
Municipal and industrial wastewater is often discharged into the environment without appropriate treatment, especially in developing countries. As a result, many rivers and oceans are contaminated. It is urgent to control and administer treatments to these contaminated rivers and oceans. However, most mechanisms of bacterial colonization in contaminated rivers and oceans were unknown, especially in sewage outlets. We found Shewanella putrefaciens to be the primary bacteria in the terrestrial sewage wastewater outlets around Ningbo City, China...
2016: Frontiers in Bioengineering and Biotechnology
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